-- dump date   	20140619_132343
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
568819000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
568819000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
568819000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819000004	Walker A motif; other site
568819000005	ATP binding site [chemical binding]; other site
568819000006	Walker B motif; other site
568819000007	arginine finger; other site
568819000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
568819000009	DnaA box-binding interface [nucleotide binding]; other site
568819000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
568819000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
568819000012	putative DNA binding surface [nucleotide binding]; other site
568819000013	dimer interface [polypeptide binding]; other site
568819000014	beta-clamp/clamp loader binding surface; other site
568819000015	beta-clamp/translesion DNA polymerase binding surface; other site
568819000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819000017	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
568819000018	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
568819000019	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
568819000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
568819000021	Walker A/P-loop; other site
568819000022	ATP binding site [chemical binding]; other site
568819000023	Q-loop/lid; other site
568819000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819000025	ABC transporter signature motif; other site
568819000026	Walker B; other site
568819000027	D-loop; other site
568819000028	H-loop/switch region; other site
568819000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
568819000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819000031	Mg2+ binding site [ion binding]; other site
568819000032	G-X-G motif; other site
568819000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
568819000034	anchoring element; other site
568819000035	dimer interface [polypeptide binding]; other site
568819000036	ATP binding site [chemical binding]; other site
568819000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568819000038	active site
568819000039	putative metal-binding site [ion binding]; other site
568819000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568819000041	DNA gyrase subunit A; Validated; Region: PRK05560
568819000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
568819000043	CAP-like domain; other site
568819000044	active site
568819000045	primary dimer interface [polypeptide binding]; other site
568819000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819000051	cardiolipin synthetase; Reviewed; Region: PRK12452
568819000052	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
568819000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568819000054	putative active site [active]
568819000055	catalytic site [active]
568819000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568819000057	putative active site [active]
568819000058	catalytic site [active]
568819000059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819000061	Coenzyme A binding pocket [chemical binding]; other site
568819000062	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
568819000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
568819000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819000065	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
568819000066	diphosphomevalonate decarboxylase; Region: PLN02407
568819000067	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
568819000068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
568819000071	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
568819000072	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
568819000073	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
568819000074	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
568819000075	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
568819000076	D-pathway; other site
568819000077	Putative ubiquinol binding site [chemical binding]; other site
568819000078	Low-spin heme (heme b) binding site [chemical binding]; other site
568819000079	Putative water exit pathway; other site
568819000080	Binuclear center (heme o3/CuB) [ion binding]; other site
568819000081	K-pathway; other site
568819000082	Putative proton exit pathway; other site
568819000083	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
568819000084	Subunit I/III interface [polypeptide binding]; other site
568819000085	Subunit III/IV interface [polypeptide binding]; other site
568819000086	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
568819000087	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568819000088	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
568819000089	putative active site [active]
568819000090	putative metal binding site [ion binding]; other site
568819000091	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
568819000092	beta-galactosidase; Region: BGL; TIGR03356
568819000093	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
568819000094	Bacterial SH3 domain; Region: SH3_3; pfam08239
568819000095	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568819000096	putative active site [active]
568819000097	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819000098	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819000099	DNA-binding site [nucleotide binding]; DNA binding site
568819000100	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568819000101	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819000102	active site
568819000103	active pocket/dimerization site; other site
568819000104	phosphorylation site [posttranslational modification]
568819000105	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
568819000106	active site
568819000107	phosphorylation site [posttranslational modification]
568819000108	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
568819000109	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
568819000110	hypothetical protein; Provisional; Region: PRK02947
568819000111	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819000112	putative active site [active]
568819000113	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
568819000114	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
568819000115	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568819000116	active site turn [active]
568819000117	phosphorylation site [posttranslational modification]
568819000118	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568819000119	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
568819000120	HPr interaction site; other site
568819000121	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819000122	active site
568819000123	phosphorylation site [posttranslational modification]
568819000124	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568819000125	putative dimer interface [polypeptide binding]; other site
568819000126	catalytic triad [active]
568819000127	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819000128	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
568819000129	Walker A/P-loop; other site
568819000130	ATP binding site [chemical binding]; other site
568819000131	Q-loop/lid; other site
568819000132	ABC transporter signature motif; other site
568819000133	Walker B; other site
568819000134	D-loop; other site
568819000135	H-loop/switch region; other site
568819000136	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
568819000139	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
568819000140	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819000141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000142	active site
568819000143	motif I; other site
568819000144	motif II; other site
568819000145	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000146	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819000147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819000148	DNA binding site [nucleotide binding]
568819000149	domain linker motif; other site
568819000150	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
568819000151	dimerization interface [polypeptide binding]; other site
568819000152	putative ligand binding site [chemical binding]; other site
568819000153	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000154	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819000155	nucleotide binding site [chemical binding]; other site
568819000156	Butyrate kinase [Energy production and conversion]; Region: COG3426
568819000157	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
568819000158	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
568819000159	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819000160	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819000161	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819000162	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819000163	dimer interface [polypeptide binding]; other site
568819000164	active site
568819000165	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819000166	dimer interface [polypeptide binding]; other site
568819000167	active site
568819000168	putrescine carbamoyltransferase; Provisional; Region: PRK02255
568819000169	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819000170	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
568819000171	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
568819000172	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
568819000173	agmatine deiminase; Provisional; Region: PRK13551
568819000174	agmatine deiminase; Region: agmatine_aguA; TIGR03380
568819000175	carbamate kinase; Reviewed; Region: PRK12686
568819000176	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
568819000177	putative substrate binding site [chemical binding]; other site
568819000178	nucleotide binding site [chemical binding]; other site
568819000179	nucleotide binding site [chemical binding]; other site
568819000180	homodimer interface [polypeptide binding]; other site
568819000181	agmatine deiminase; Provisional; Region: PRK13551
568819000182	agmatine deiminase; Region: agmatine_aguA; TIGR03380
568819000183	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819000184	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819000185	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819000186	putative active site [active]
568819000187	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
568819000188	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568819000189	arginine deiminase; Provisional; Region: PRK01388
568819000190	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
568819000191	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
568819000192	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568819000193	dimer interface [polypeptide binding]; other site
568819000194	ssDNA binding site [nucleotide binding]; other site
568819000195	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819000196	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
568819000197	Predicted membrane protein [Function unknown]; Region: COG3212
568819000198	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000199	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000200	putative accessory gene regulator protein; Provisional; Region: PRK01100
568819000201	Staphylococcal AgrD protein; Region: AgrD; cl05477
568819000202	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
568819000203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819000204	ATP binding site [chemical binding]; other site
568819000205	Mg2+ binding site [ion binding]; other site
568819000206	G-X-G motif; other site
568819000207	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568819000208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819000209	active site
568819000210	phosphorylation site [posttranslational modification]
568819000211	intermolecular recognition site; other site
568819000212	LytTr DNA-binding domain; Region: LytTR; pfam04397
568819000213	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
568819000214	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
568819000215	DHH family; Region: DHH; pfam01368
568819000216	DHHA1 domain; Region: DHHA1; pfam02272
568819000217	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
568819000218	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
568819000219	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
568819000220	replicative DNA helicase; Provisional; Region: PRK05748
568819000221	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
568819000222	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
568819000223	Walker A motif; other site
568819000224	ATP binding site [chemical binding]; other site
568819000225	Walker B motif; other site
568819000226	DNA binding loops [nucleotide binding]
568819000227	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
568819000228	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
568819000229	GDP-binding site [chemical binding]; other site
568819000230	ACT binding site; other site
568819000231	IMP binding site; other site
568819000232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
568819000233	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819000234	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
568819000235	Predicted membrane protein [Function unknown]; Region: COG1511
568819000236	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
568819000237	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
568819000238	Uncharacterized small protein [Function unknown]; Region: COG5417
568819000239	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
568819000240	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
568819000241	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
568819000242	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
568819000243	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568819000244	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568819000245	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
568819000246	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
568819000249	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
568819000250	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
568819000251	tetramer interface [polypeptide binding]; other site
568819000252	active site
568819000253	Mg2+/Mn2+ binding site [ion binding]; other site
568819000254	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
568819000255	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
568819000256	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
568819000257	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819000258	DNA binding site [nucleotide binding]
568819000259	active site
568819000260	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
568819000261	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
568819000262	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
568819000263	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
568819000264	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
568819000265	putative ligand binding site [chemical binding]; other site
568819000266	putative NAD binding site [chemical binding]; other site
568819000267	catalytic site [active]
568819000268	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819000269	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819000270	DNA binding residues [nucleotide binding]
568819000271	putative dimer interface [polypeptide binding]; other site
568819000272	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819000273	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819000274	active site
568819000275	catalytic tetrad [active]
568819000276	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000277	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819000278	ATP synthase subunit C; Region: ATP-synt_C; cl00466
568819000279	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
568819000280	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
568819000281	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568819000282	Walker A motif; other site
568819000283	ATP binding site [chemical binding]; other site
568819000284	Walker B motif; other site
568819000285	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819000286	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
568819000287	core domain interface [polypeptide binding]; other site
568819000288	delta subunit interface [polypeptide binding]; other site
568819000289	epsilon subunit interface [polypeptide binding]; other site
568819000290	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
568819000291	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
568819000292	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
568819000293	alpha subunit interaction interface [polypeptide binding]; other site
568819000294	Walker A motif; other site
568819000295	ATP binding site [chemical binding]; other site
568819000296	Walker B motif; other site
568819000297	inhibitor binding site; inhibition site
568819000298	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819000299	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823
568819000300	gamma subunit interface [polypeptide binding]; other site
568819000301	epsilon subunit interface [polypeptide binding]; other site
568819000302	LBP interface [polypeptide binding]; other site
568819000303	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000304	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
568819000305	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819000306	active pocket/dimerization site; other site
568819000307	active site
568819000308	phosphorylation site [posttranslational modification]
568819000309	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
568819000310	active site
568819000311	phosphorylation site [posttranslational modification]
568819000312	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
568819000313	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
568819000314	Domain of unknown function (DUF956); Region: DUF956; pfam06115
568819000315	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
568819000316	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
568819000317	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
568819000318	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819000319	dimerization interface [polypeptide binding]; other site
568819000320	putative DNA binding site [nucleotide binding]; other site
568819000321	Uncharacterized conserved protein [Function unknown]; Region: COG1359
568819000322	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
568819000323	dimer interface [polypeptide binding]; other site
568819000324	FMN binding site [chemical binding]; other site
568819000325	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
568819000326	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
568819000327	active site
568819000328	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
568819000329	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568819000330	Interdomain contacts; other site
568819000331	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
568819000332	aromatic chitin/cellulose binding site residues [chemical binding]; other site
568819000333	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000334	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819000335	nucleotide binding site [chemical binding]; other site
568819000336	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819000337	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819000338	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
568819000339	Walker A/P-loop; other site
568819000340	ATP binding site [chemical binding]; other site
568819000341	Q-loop/lid; other site
568819000342	ABC transporter signature motif; other site
568819000343	Walker B; other site
568819000344	D-loop; other site
568819000345	H-loop/switch region; other site
568819000346	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819000347	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819000348	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819000349	Walker A/P-loop; other site
568819000350	ATP binding site [chemical binding]; other site
568819000351	Q-loop/lid; other site
568819000352	ABC transporter signature motif; other site
568819000353	Walker B; other site
568819000354	D-loop; other site
568819000355	H-loop/switch region; other site
568819000356	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
568819000357	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819000358	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819000359	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819000360	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
568819000361	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
568819000362	substrate binding pocket [chemical binding]; other site
568819000363	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819000364	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000365	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819000366	ligand binding site [chemical binding]; other site
568819000367	flexible hinge region; other site
568819000368	Domain of unknown function (DUF955); Region: DUF955; pfam06114
568819000369	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819000370	non-specific DNA binding site [nucleotide binding]; other site
568819000371	salt bridge; other site
568819000372	sequence-specific DNA binding site [nucleotide binding]; other site
568819000373	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568819000374	Predicted secreted protein [Function unknown]; Region: COG5437
568819000375	Phage-related protein [Function unknown]; Region: COG5412
568819000376	Phage tail protein; Region: Sipho_tail; pfam05709
568819000377	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
568819000378	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
568819000379	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568819000380	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568819000381	active site
568819000382	metal binding site [ion binding]; metal-binding site
568819000383	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568819000384	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
568819000385	putative active site [active]
568819000386	putative metal binding site [ion binding]; other site
568819000387	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568819000388	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819000389	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
568819000390	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
568819000391	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
568819000392	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
568819000393	active site
568819000394	Uncharacterized conserved protein [Function unknown]; Region: COG3592
568819000395	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819000396	Coenzyme A binding pocket [chemical binding]; other site
568819000397	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
568819000398	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
568819000399	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568819000400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000401	dimer interface [polypeptide binding]; other site
568819000402	conserved gate region; other site
568819000403	putative PBP binding loops; other site
568819000404	ABC-ATPase subunit interface; other site
568819000405	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568819000406	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
568819000407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000408	dimer interface [polypeptide binding]; other site
568819000409	conserved gate region; other site
568819000410	putative PBP binding loops; other site
568819000411	ABC-ATPase subunit interface; other site
568819000412	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
568819000413	LXG domain of WXG superfamily; Region: LXG; pfam04740
568819000414	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
568819000415	phosphoenolpyruvate synthase; Validated; Region: PRK06464
568819000417	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819000418	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819000419	peptide binding site [polypeptide binding]; other site
568819000420	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
568819000421	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
568819000422	metal binding site [ion binding]; metal-binding site
568819000423	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
568819000424	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
568819000425	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
568819000426	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819000427	ABC-ATPase subunit  interface; other site
568819000428	dimer interface [polypeptide binding]; other site
568819000429	putative PBP binding regions; other site
568819000430	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819000431	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000432	ligand binding site [chemical binding]; other site
568819000433	flexible hinge region; other site
568819000434	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
568819000435	DEAD_2; Region: DEAD_2; pfam06733
568819000436	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
568819000437	sugar phosphate phosphatase; Provisional; Region: PRK10513
568819000438	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000439	active site
568819000440	motif I; other site
568819000441	motif II; other site
568819000442	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000443	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819000444	Collagen binding domain; Region: Collagen_bind; pfam05737
568819000445	Cna protein B-type domain; Region: Cna_B; pfam05738
568819000446	Cna protein B-type domain; Region: Cna_B; pfam05738
568819000447	Cna protein B-type domain; Region: Cna_B; pfam05738
568819000450	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819000451	DNA polymerase III subunit delta'; Validated; Region: PRK08058
568819000452	DNA polymerase III subunit delta'; Validated; Region: PRK08485
568819000453	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
568819000454	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
568819000455	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
568819000456	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819000457	S-adenosylmethionine binding site [chemical binding]; other site
568819000458	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
568819000459	GIY-YIG motif/motif A; other site
568819000460	putative active site [active]
568819000461	putative metal binding site [ion binding]; other site
568819000462	Predicted methyltransferases [General function prediction only]; Region: COG0313
568819000463	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
568819000464	putative SAM binding site [chemical binding]; other site
568819000465	putative homodimer interface [polypeptide binding]; other site
568819000466	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
568819000467	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
568819000468	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819000469	Uncharacterized conserved protein [Function unknown]; Region: COG5361
568819000470	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
568819000471	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
568819000472	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819000473	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819000474	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
568819000475	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
568819000476	active site
568819000477	HIGH motif; other site
568819000478	KMSKS motif; other site
568819000479	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
568819000480	tRNA binding surface [nucleotide binding]; other site
568819000481	anticodon binding site; other site
568819000482	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
568819000483	dimer interface [polypeptide binding]; other site
568819000484	putative tRNA-binding site [nucleotide binding]; other site
568819000485	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
568819000486	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819000487	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819000488	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568819000489	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819000490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000491	dimer interface [polypeptide binding]; other site
568819000492	conserved gate region; other site
568819000493	putative PBP binding loops; other site
568819000494	ABC-ATPase subunit interface; other site
568819000495	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819000496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000497	dimer interface [polypeptide binding]; other site
568819000498	conserved gate region; other site
568819000499	putative PBP binding loops; other site
568819000500	ABC-ATPase subunit interface; other site
568819000501	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819000502	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819000503	alpha-glucosidase; Provisional; Region: PRK10426
568819000504	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
568819000505	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
568819000506	active site
568819000507	catalytic site [active]
568819000508	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819000509	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
568819000510	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
568819000511	trimer interface [polypeptide binding]; other site
568819000512	active site
568819000513	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
568819000514	catalytic site [active]
568819000515	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819000516	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568819000517	Ca binding site [ion binding]; other site
568819000518	active site
568819000519	catalytic site [active]
568819000520	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
568819000521	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
568819000522	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
568819000523	active site
568819000524	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
568819000525	Domain of unknown function (DUF348); Region: DUF348; pfam03990
568819000526	Domain of unknown function (DUF348); Region: DUF348; pfam03990
568819000527	G5 domain; Region: G5; pfam07501
568819000528	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568819000529	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
568819000530	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
568819000531	putative active site [active]
568819000532	putative metal binding site [ion binding]; other site
568819000533	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
568819000534	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
568819000535	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819000536	S-adenosylmethionine binding site [chemical binding]; other site
568819000537	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
568819000538	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
568819000539	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819000540	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
568819000541	putative active site [active]
568819000542	YdjC motif; other site
568819000543	Mg binding site [ion binding]; other site
568819000544	putative homodimer interface [polypeptide binding]; other site
568819000545	pur operon repressor; Provisional; Region: PRK09213
568819000546	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
568819000547	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819000548	active site
568819000549	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568819000550	HlyD family secretion protein; Region: HlyD_3; pfam13437
568819000551	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819000552	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819000553	Walker A/P-loop; other site
568819000554	ATP binding site [chemical binding]; other site
568819000555	Q-loop/lid; other site
568819000556	ABC transporter signature motif; other site
568819000557	Walker B; other site
568819000558	D-loop; other site
568819000559	H-loop/switch region; other site
568819000560	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819000561	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819000562	FtsX-like permease family; Region: FtsX; pfam02687
568819000563	regulatory protein SpoVG; Reviewed; Region: PRK13259
568819000564	regulatory protein SpoVG; Reviewed; Region: PRK13259
568819000565	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
568819000566	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
568819000567	Substrate binding site; other site
568819000568	Mg++ binding site; other site
568819000569	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
568819000570	active site
568819000571	substrate binding site [chemical binding]; other site
568819000572	CoA binding site [chemical binding]; other site
568819000573	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
568819000574	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
568819000575	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819000576	active site
568819000577	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000578	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819000579	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819000580	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
568819000581	active site
568819000582	catalytic site [active]
568819000583	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
568819000584	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
568819000585	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
568819000586	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819000587	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
568819000588	active site
568819000589	Zn binding site [ion binding]; other site
568819000590	ActA Protein; Region: ActA; pfam05058
568819000591	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
568819000592	Zn binding site [ion binding]; other site
568819000593	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
568819000594	hypothetical protein; Provisional; Region: PRK01119
568819000595	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
568819000596	A new structural DNA glycosylase; Region: AlkD_like; cd06561
568819000597	active site
568819000598	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
568819000599	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819000600	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819000601	NAD binding site [chemical binding]; other site
568819000602	dimer interface [polypeptide binding]; other site
568819000603	substrate binding site [chemical binding]; other site
568819000604	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
568819000605	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
568819000606	5S rRNA interface [nucleotide binding]; other site
568819000607	CTC domain interface [polypeptide binding]; other site
568819000608	L16 interface [polypeptide binding]; other site
568819000609	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819000610	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819000611	Coenzyme A binding pocket [chemical binding]; other site
568819000612	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
568819000613	putative active site [active]
568819000614	catalytic residue [active]
568819000615	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
568819000616	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
568819000617	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819000618	ATP binding site [chemical binding]; other site
568819000619	putative Mg++ binding site [ion binding]; other site
568819000620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819000621	nucleotide binding region [chemical binding]; other site
568819000622	ATP-binding site [chemical binding]; other site
568819000623	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
568819000624	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568819000625	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568819000626	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819000627	RNA binding surface [nucleotide binding]; other site
568819000628	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
568819000629	Septum formation initiator; Region: DivIC; pfam04977
568819000630	hypothetical protein; Provisional; Region: PRK08582
568819000631	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
568819000632	RNA binding site [nucleotide binding]; other site
568819000633	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
568819000634	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
568819000635	Ligand Binding Site [chemical binding]; other site
568819000636	TilS substrate C-terminal domain; Region: TilS_C; smart00977
568819000637	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
568819000638	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819000639	active site
568819000640	FtsH Extracellular; Region: FtsH_ext; pfam06480
568819000641	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
568819000642	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819000643	Walker A motif; other site
568819000644	ATP binding site [chemical binding]; other site
568819000645	Walker B motif; other site
568819000646	arginine finger; other site
568819000647	Peptidase family M41; Region: Peptidase_M41; pfam01434
568819000648	pantothenate kinase; Reviewed; Region: PRK13318
568819000649	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
568819000650	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
568819000651	dimerization interface [polypeptide binding]; other site
568819000652	domain crossover interface; other site
568819000653	redox-dependent activation switch; other site
568819000654	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
568819000655	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
568819000656	dimer interface [polypeptide binding]; other site
568819000657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819000658	catalytic residue [active]
568819000659	dihydropteroate synthase; Region: DHPS; TIGR01496
568819000660	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
568819000661	substrate binding pocket [chemical binding]; other site
568819000662	dimer interface [polypeptide binding]; other site
568819000663	inhibitor binding site; inhibition site
568819000664	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
568819000665	homooctamer interface [polypeptide binding]; other site
568819000666	active site
568819000667	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
568819000668	catalytic center binding site [active]
568819000669	ATP binding site [chemical binding]; other site
568819000670	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
568819000671	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
568819000672	FMN binding site [chemical binding]; other site
568819000673	active site
568819000674	catalytic residues [active]
568819000675	substrate binding site [chemical binding]; other site
568819000676	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
568819000677	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
568819000678	dimer interface [polypeptide binding]; other site
568819000679	putative anticodon binding site; other site
568819000680	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
568819000681	motif 1; other site
568819000682	active site
568819000683	motif 2; other site
568819000684	motif 3; other site
568819000685	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
568819000686	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
568819000687	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
568819000688	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
568819000689	ADP binding site [chemical binding]; other site
568819000690	phosphagen binding site; other site
568819000691	substrate specificity loop; other site
568819000692	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
568819000693	Clp amino terminal domain; Region: Clp_N; pfam02861
568819000694	Clp amino terminal domain; Region: Clp_N; pfam02861
568819000695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819000696	Walker A motif; other site
568819000697	ATP binding site [chemical binding]; other site
568819000698	Walker B motif; other site
568819000699	arginine finger; other site
568819000700	UvrB/uvrC motif; Region: UVR; pfam02151
568819000701	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819000702	Walker A motif; other site
568819000703	ATP binding site [chemical binding]; other site
568819000704	Walker B motif; other site
568819000705	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568819000706	DNA repair protein RadA; Provisional; Region: PRK11823
568819000707	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
568819000708	Walker A motif/ATP binding site; other site
568819000709	ATP binding site [chemical binding]; other site
568819000710	Walker B motif; other site
568819000711	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
568819000712	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
568819000713	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
568819000714	putative active site [active]
568819000715	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
568819000716	substrate binding site; other site
568819000717	dimer interface; other site
568819000718	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
568819000719	homotrimer interaction site [polypeptide binding]; other site
568819000720	zinc binding site [ion binding]; other site
568819000721	CDP-binding sites; other site
568819000722	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
568819000723	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568819000724	HIGH motif; other site
568819000725	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
568819000726	active site
568819000727	KMSKS motif; other site
568819000728	serine O-acetyltransferase; Region: cysE; TIGR01172
568819000729	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
568819000730	trimer interface [polypeptide binding]; other site
568819000731	active site
568819000732	substrate binding site [chemical binding]; other site
568819000733	CoA binding site [chemical binding]; other site
568819000734	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
568819000735	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568819000736	active site
568819000737	HIGH motif; other site
568819000738	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
568819000739	KMSKS motif; other site
568819000740	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
568819000741	tRNA binding surface [nucleotide binding]; other site
568819000742	anticodon binding site; other site
568819000743	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
568819000744	active site
568819000745	metal binding site [ion binding]; metal-binding site
568819000746	dimerization interface [polypeptide binding]; other site
568819000747	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
568819000748	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
568819000749	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
568819000750	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
568819000751	RNA polymerase factor sigma-70; Validated; Region: PRK08295
568819000752	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819000753	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
568819000754	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
568819000755	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
568819000756	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
568819000757	putative homodimer interface [polypeptide binding]; other site
568819000758	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
568819000759	heterodimer interface [polypeptide binding]; other site
568819000760	homodimer interface [polypeptide binding]; other site
568819000761	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
568819000762	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
568819000763	23S rRNA interface [nucleotide binding]; other site
568819000764	L7/L12 interface [polypeptide binding]; other site
568819000765	putative thiostrepton binding site; other site
568819000766	L25 interface [polypeptide binding]; other site
568819000767	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
568819000768	mRNA/rRNA interface [nucleotide binding]; other site
568819000769	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
568819000770	23S rRNA interface [nucleotide binding]; other site
568819000771	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
568819000772	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
568819000773	core dimer interface [polypeptide binding]; other site
568819000774	peripheral dimer interface [polypeptide binding]; other site
568819000775	L10 interface [polypeptide binding]; other site
568819000776	L11 interface [polypeptide binding]; other site
568819000777	putative EF-Tu interaction site [polypeptide binding]; other site
568819000778	putative EF-G interaction site [polypeptide binding]; other site
568819000779	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568819000780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819000781	S-adenosylmethionine binding site [chemical binding]; other site
568819000782	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
568819000783	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819000784	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819000785	DNA binding site [nucleotide binding]
568819000786	domain linker motif; other site
568819000787	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819000788	putative dimerization interface [polypeptide binding]; other site
568819000789	putative ligand binding site [chemical binding]; other site
568819000790	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
568819000791	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819000792	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819000793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000794	dimer interface [polypeptide binding]; other site
568819000795	conserved gate region; other site
568819000796	putative PBP binding loops; other site
568819000797	ABC-ATPase subunit interface; other site
568819000798	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819000799	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000800	dimer interface [polypeptide binding]; other site
568819000801	conserved gate region; other site
568819000802	putative PBP binding loops; other site
568819000803	ABC-ATPase subunit interface; other site
568819000804	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819000805	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568819000806	Ca binding site [ion binding]; other site
568819000807	active site
568819000808	catalytic site [active]
568819000809	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
568819000810	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
568819000811	active site
568819000812	homodimer interface [polypeptide binding]; other site
568819000813	catalytic site [active]
568819000814	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
568819000815	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568819000816	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568819000817	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
568819000818	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
568819000819	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
568819000820	RPB10 interaction site [polypeptide binding]; other site
568819000821	RPB1 interaction site [polypeptide binding]; other site
568819000822	RPB11 interaction site [polypeptide binding]; other site
568819000823	RPB3 interaction site [polypeptide binding]; other site
568819000824	RPB12 interaction site [polypeptide binding]; other site
568819000825	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
568819000826	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
568819000827	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
568819000828	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
568819000829	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
568819000830	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
568819000831	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
568819000832	G-loop; other site
568819000833	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
568819000834	DNA binding site [nucleotide binding]
568819000835	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
568819000836	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
568819000837	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000838	active site
568819000839	motif I; other site
568819000840	motif II; other site
568819000841	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819000842	beta-galactosidase; Region: BGL; TIGR03356
568819000843	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819000844	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
568819000845	Walker A/P-loop; other site
568819000846	ATP binding site [chemical binding]; other site
568819000847	Q-loop/lid; other site
568819000848	ABC transporter signature motif; other site
568819000849	Walker B; other site
568819000850	D-loop; other site
568819000851	H-loop/switch region; other site
568819000852	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819000853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
568819000854	Walker A/P-loop; other site
568819000855	ATP binding site [chemical binding]; other site
568819000856	Q-loop/lid; other site
568819000857	ABC transporter signature motif; other site
568819000858	Walker B; other site
568819000859	D-loop; other site
568819000860	H-loop/switch region; other site
568819000861	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819000862	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000863	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819000864	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000865	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000866	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000867	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000868	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000869	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000870	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819000871	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819000872	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000873	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819000874	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000875	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000876	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000877	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000878	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000879	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000880	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000881	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819000882	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819000883	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819000884	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000885	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000886	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819000887	Leucine-rich repeats; other site
568819000888	Substrate binding site [chemical binding]; other site
568819000889	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000890	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000891	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000892	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000893	LRR adjacent; Region: LRR_adjacent; pfam08191
568819000894	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819000895	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819000896	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
568819000897	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
568819000898	metal binding site [ion binding]; metal-binding site
568819000899	dimer interface [polypeptide binding]; other site
568819000900	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819000901	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819000902	putative Zn2+ binding site [ion binding]; other site
568819000903	putative DNA binding site [nucleotide binding]; other site
568819000904	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819000905	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819000906	Zn binding site [ion binding]; other site
568819000907	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819000908	Zn binding site [ion binding]; other site
568819000909	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819000910	catalytic core [active]
568819000911	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
568819000912	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568819000913	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568819000914	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000915	dimer interface [polypeptide binding]; other site
568819000916	conserved gate region; other site
568819000917	ABC-ATPase subunit interface; other site
568819000918	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819000919	Substrate binding site [chemical binding]; other site
568819000920	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000921	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000922	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000923	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000924	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819000925	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
568819000926	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819000927	beta-galactosidase; Region: BGL; TIGR03356
568819000928	sugar phosphate phosphatase; Provisional; Region: PRK10513
568819000929	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000930	active site
568819000931	motif I; other site
568819000932	motif II; other site
568819000933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819000935	Coenzyme A binding pocket [chemical binding]; other site
568819000936	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000937	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
568819000938	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
568819000939	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
568819000940	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000941	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
568819000942	active site
568819000943	motif I; other site
568819000944	motif II; other site
568819000945	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819000946	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819000947	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819000948	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568819000949	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
568819000950	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
568819000951	Walker A/P-loop; other site
568819000952	ATP binding site [chemical binding]; other site
568819000953	Q-loop/lid; other site
568819000954	ABC transporter signature motif; other site
568819000955	Walker B; other site
568819000956	D-loop; other site
568819000957	H-loop/switch region; other site
568819000958	TOBE domain; Region: TOBE; pfam03459
568819000959	ATP cone domain; Region: ATP-cone; pfam03477
568819000960	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
568819000961	Class III ribonucleotide reductase; Region: RNR_III; cd01675
568819000962	effector binding site; other site
568819000963	active site
568819000964	Zn binding site [ion binding]; other site
568819000965	glycine loop; other site
568819000966	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
568819000967	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
568819000968	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819000969	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819000970	ligand binding site [chemical binding]; other site
568819000971	flexible hinge region; other site
568819000972	Predicted amidohydrolase [General function prediction only]; Region: COG0388
568819000973	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
568819000974	putative active site [active]
568819000975	catalytic triad [active]
568819000976	putative dimer interface [polypeptide binding]; other site
568819000977	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819000978	dimer interface [polypeptide binding]; other site
568819000979	conserved gate region; other site
568819000980	ABC-ATPase subunit interface; other site
568819000981	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
568819000982	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
568819000983	Walker A/P-loop; other site
568819000984	ATP binding site [chemical binding]; other site
568819000985	Q-loop/lid; other site
568819000986	ABC transporter signature motif; other site
568819000987	Walker B; other site
568819000988	D-loop; other site
568819000989	H-loop/switch region; other site
568819000990	NIL domain; Region: NIL; pfam09383
568819000991	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568819000992	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568819000993	transaminase; Reviewed; Region: PRK08068
568819000994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819000995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819000996	homodimer interface [polypeptide binding]; other site
568819000997	catalytic residue [active]
568819000998	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819000999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819001000	active site
568819001001	phosphorylation site [posttranslational modification]
568819001002	intermolecular recognition site; other site
568819001003	dimerization interface [polypeptide binding]; other site
568819001004	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819001005	DNA binding site [nucleotide binding]
568819001006	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
568819001007	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819001008	dimerization interface [polypeptide binding]; other site
568819001009	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568819001010	putative active site [active]
568819001011	heme pocket [chemical binding]; other site
568819001012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819001013	dimer interface [polypeptide binding]; other site
568819001014	phosphorylation site [posttranslational modification]
568819001015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819001016	ATP binding site [chemical binding]; other site
568819001017	Mg2+ binding site [ion binding]; other site
568819001018	G-X-G motif; other site
568819001019	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
568819001020	YycH protein; Region: YycH; pfam07435
568819001021	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
568819001022	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
568819001023	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
568819001024	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
568819001025	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
568819001026	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
568819001027	protein binding site [polypeptide binding]; other site
568819001028	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
568819001029	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001030	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819001031	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819001032	dimerization interface [polypeptide binding]; other site
568819001033	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
568819001034	dimer interface [polypeptide binding]; other site
568819001035	FMN binding site [chemical binding]; other site
568819001036	NADPH bind site [chemical binding]; other site
568819001037	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001038	HTH domain; Region: HTH_11; pfam08279
568819001039	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819001040	PRD domain; Region: PRD; pfam00874
568819001041	PRD domain; Region: PRD; pfam00874
568819001042	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001043	active site
568819001044	P-loop; other site
568819001045	phosphorylation site [posttranslational modification]
568819001046	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001047	active site
568819001048	phosphorylation site [posttranslational modification]
568819001049	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819001050	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819001051	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819001052	active site
568819001053	P-loop; other site
568819001054	phosphorylation site [posttranslational modification]
568819001055	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819001056	beta-galactosidase; Region: BGL; TIGR03356
568819001057	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819001058	methionine cluster; other site
568819001059	active site
568819001060	phosphorylation site [posttranslational modification]
568819001061	metal binding site [ion binding]; metal-binding site
568819001062	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
568819001063	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819001064	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819001065	catalytic residue [active]
568819001066	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
568819001067	putative active site [active]
568819001068	YdjC motif; other site
568819001069	Mg binding site [ion binding]; other site
568819001070	putative homodimer interface [polypeptide binding]; other site
568819001071	Putative transcription activator [Transcription]; Region: TenA; COG0819
568819001072	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
568819001073	substrate binding site [chemical binding]; other site
568819001074	multimerization interface [polypeptide binding]; other site
568819001075	ATP binding site [chemical binding]; other site
568819001076	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568819001077	dimer interface [polypeptide binding]; other site
568819001078	substrate binding site [chemical binding]; other site
568819001079	ATP binding site [chemical binding]; other site
568819001080	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
568819001081	thiamine phosphate binding site [chemical binding]; other site
568819001082	active site
568819001083	pyrophosphate binding site [ion binding]; other site
568819001084	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819001085	beta-galactosidase; Region: BGL; TIGR03356
568819001086	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001087	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
568819001088	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
568819001089	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
568819001090	putative catalytic site [active]
568819001091	putative metal binding site [ion binding]; other site
568819001092	putative phosphate binding site [ion binding]; other site
568819001093	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819001094	non-specific DNA binding site [nucleotide binding]; other site
568819001095	salt bridge; other site
568819001096	sequence-specific DNA binding site [nucleotide binding]; other site
568819001097	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
568819001098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819001099	non-specific DNA binding site [nucleotide binding]; other site
568819001100	salt bridge; other site
568819001101	sequence-specific DNA binding site [nucleotide binding]; other site
568819001102	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
568819001103	Leucine rich repeat; Region: LRR_8; pfam13855
568819001104	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001105	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001106	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001107	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001108	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001109	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001110	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001111	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001112	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001113	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001114	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001115	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001116	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001117	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001118	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001119	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001120	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001121	Leucine rich repeat; Region: LRR_8; pfam13855
568819001122	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001123	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001124	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819001125	Leucine-rich repeats; other site
568819001126	Substrate binding site [chemical binding]; other site
568819001127	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001128	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001129	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001130	Leucine rich repeat; Region: LRR_8; pfam13855
568819001131	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819001132	Leucine-rich repeats; other site
568819001133	Leucine rich repeat; Region: LRR_8; pfam13855
568819001134	Substrate binding site [chemical binding]; other site
568819001135	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001136	Leucine rich repeat; Region: LRR_8; pfam13855
568819001137	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001138	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001139	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001140	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001141	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001142	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001143	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001144	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
568819001145	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
568819001146	LXG domain of WXG superfamily; Region: LXG; pfam04740
568819001147	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
568819001148	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819001149	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819001150	TPP-binding site [chemical binding]; other site
568819001151	dimer interface [polypeptide binding]; other site
568819001152	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819001153	PYR/PP interface [polypeptide binding]; other site
568819001154	dimer interface [polypeptide binding]; other site
568819001155	TPP binding site [chemical binding]; other site
568819001156	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819001157	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568819001158	active site
568819001159	intersubunit interactions; other site
568819001160	catalytic residue [active]
568819001161	short chain dehydrogenase; Provisional; Region: PRK06841
568819001162	classical (c) SDRs; Region: SDR_c; cd05233
568819001163	NAD(P) binding site [chemical binding]; other site
568819001164	active site
568819001165	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
568819001166	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
568819001167	substrate binding site [chemical binding]; other site
568819001168	dimer interface [polypeptide binding]; other site
568819001169	catalytic triad [active]
568819001170	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819001171	DAK2 domain; Region: Dak2; cl03685
568819001172	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
568819001173	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819001174	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
568819001175	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001176	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819001177	putative DNA binding site [nucleotide binding]; other site
568819001178	putative Zn2+ binding site [ion binding]; other site
568819001179	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819001180	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819001181	Coenzyme A binding pocket [chemical binding]; other site
568819001182	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001183	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819001184	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001185	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001186	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001187	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
568819001188	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568819001189	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
568819001190	acyl-activating enzyme (AAE) consensus motif; other site
568819001191	acyl-activating enzyme (AAE) consensus motif; other site
568819001192	AMP binding site [chemical binding]; other site
568819001193	active site
568819001194	CoA binding site [chemical binding]; other site
568819001195	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
568819001196	L-aspartate oxidase; Provisional; Region: PRK06175
568819001197	putative oxidoreductase; Provisional; Region: PRK10206
568819001198	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819001199	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568819001200	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001201	active site
568819001202	phosphorylation site [posttranslational modification]
568819001203	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
568819001204	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819001205	active site
568819001206	P-loop; other site
568819001207	phosphorylation site [posttranslational modification]
568819001208	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819001209	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568819001210	intersubunit interface [polypeptide binding]; other site
568819001211	active site
568819001212	zinc binding site [ion binding]; other site
568819001213	Na+ binding site [ion binding]; other site
568819001214	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001215	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
568819001216	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819001217	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
568819001218	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
568819001219	Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340
568819001220	conserved cys residue [active]
568819001221	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819001222	HTH domain; Region: HTH_11; pfam08279
568819001223	WYL domain; Region: WYL; pfam13280
568819001224	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
568819001225	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
568819001226	Imelysin; Region: Peptidase_M75; pfam09375
568819001227	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
568819001228	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
568819001229	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
568819001230	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
568819001231	nudix motif; other site
568819001232	hypothetical protein; Provisional; Region: PRK12378
568819001233	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
568819001234	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
568819001235	PhnA protein; Region: PhnA; pfam03831
568819001236	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819001237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001238	DNA-binding site [nucleotide binding]; DNA binding site
568819001239	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568819001240	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819001241	beta-galactosidase; Region: BGL; TIGR03356
568819001242	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819001243	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
568819001244	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819001245	active site
568819001246	P-loop; other site
568819001247	phosphorylation site [posttranslational modification]
568819001248	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819001249	HTH domain; Region: HTH_11; pfam08279
568819001250	WYL domain; Region: WYL; pfam13280
568819001251	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
568819001254	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819001255	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568819001256	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819001257	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
568819001258	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
568819001259	tetrameric interface [polypeptide binding]; other site
568819001260	NAD binding site [chemical binding]; other site
568819001261	catalytic residues [active]
568819001262	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
568819001263	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568819001264	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
568819001265	substrate binding site [chemical binding]; other site
568819001266	ATP binding site [chemical binding]; other site
568819001267	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
568819001268	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819001269	PYR/PP interface [polypeptide binding]; other site
568819001270	dimer interface [polypeptide binding]; other site
568819001271	TPP binding site [chemical binding]; other site
568819001272	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819001273	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
568819001274	TPP-binding site; other site
568819001275	Uncharacterized conserved protein [Function unknown]; Region: COG5646
568819001276	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
568819001277	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
568819001278	ligand binding site [chemical binding]; other site
568819001279	active site
568819001280	UGI interface [polypeptide binding]; other site
568819001281	catalytic site [active]
568819001282	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
568819001283	hypothetical protein; Provisional; Region: PRK13665
568819001284	Bacterial SH3 domain; Region: SH3_3; cl17532
568819001285	NlpC/P60 family; Region: NLPC_P60; pfam00877
568819001287	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
568819001288	pyrroline-5-carboxylate reductase; Region: PLN02688
568819001289	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819001290	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001291	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819001292	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001293	DNA-binding site [nucleotide binding]; DNA binding site
568819001294	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
568819001295	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819001296	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819001297	Walker A/P-loop; other site
568819001298	ATP binding site [chemical binding]; other site
568819001299	Q-loop/lid; other site
568819001300	ABC transporter signature motif; other site
568819001301	Walker B; other site
568819001302	D-loop; other site
568819001303	H-loop/switch region; other site
568819001304	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819001305	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819001306	FtsX-like permease family; Region: FtsX; pfam02687
568819001307	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
568819001308	putative hydrophobic ligand binding site [chemical binding]; other site
568819001309	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001310	active site
568819001311	phosphorylation site [posttranslational modification]
568819001312	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819001313	active site
568819001314	P-loop; other site
568819001315	phosphorylation site [posttranslational modification]
568819001316	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819001317	alpha-mannosidase; Provisional; Region: PRK09819
568819001318	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
568819001319	active site
568819001320	metal binding site [ion binding]; metal-binding site
568819001321	catalytic site [active]
568819001322	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
568819001323	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001324	HTH domain; Region: HTH_11; pfam08279
568819001325	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819001326	PRD domain; Region: PRD; pfam00874
568819001327	PRD domain; Region: PRD; pfam00874
568819001328	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001329	active site
568819001330	P-loop; other site
568819001331	phosphorylation site [posttranslational modification]
568819001332	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001333	active site
568819001334	phosphorylation site [posttranslational modification]
568819001335	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
568819001336	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
568819001337	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819001338	putative metal binding site [ion binding]; other site
568819001339	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
568819001340	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
568819001341	trimer interface [polypeptide binding]; other site
568819001342	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001343	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001344	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819001345	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001346	Leucine-rich repeats; other site
568819001347	Substrate binding site [chemical binding]; other site
568819001348	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001349	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001350	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001351	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001352	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001353	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001354	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001355	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001356	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001357	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001358	phosphoenolpyruvate synthase; Validated; Region: PRK06241
568819001359	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
568819001360	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
568819001361	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
568819001362	ZIP Zinc transporter; Region: Zip; pfam02535
568819001363	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
568819001364	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
568819001365	NodB motif; other site
568819001366	active site
568819001367	catalytic site [active]
568819001368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819001369	non-specific DNA binding site [nucleotide binding]; other site
568819001370	salt bridge; other site
568819001371	sequence-specific DNA binding site [nucleotide binding]; other site
568819001372	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
568819001373	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819001374	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819001375	active site
568819001376	motif I; other site
568819001377	motif II; other site
568819001378	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819001379	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
568819001380	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001381	HTH domain; Region: HTH_11; pfam08279
568819001382	PRD domain; Region: PRD; pfam00874
568819001383	PRD domain; Region: PRD; pfam00874
568819001384	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001385	active site
568819001386	P-loop; other site
568819001387	phosphorylation site [posttranslational modification]
568819001388	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001389	active site
568819001390	phosphorylation site [posttranslational modification]
568819001391	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001392	active site
568819001393	phosphorylation site [posttranslational modification]
568819001394	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819001395	active site
568819001396	P-loop; other site
568819001397	phosphorylation site [posttranslational modification]
568819001398	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819001399	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819001400	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
568819001401	active site
568819001402	metal binding site [ion binding]; metal-binding site
568819001403	catalytic site [active]
568819001404	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819001405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001406	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819001407	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819001408	dimerization interface [polypeptide binding]; other site
568819001409	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
568819001410	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
568819001411	active site
568819001412	substrate binding site [chemical binding]; other site
568819001413	trimer interface [polypeptide binding]; other site
568819001414	CoA binding site [chemical binding]; other site
568819001415	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
568819001416	classical (c) SDRs; Region: SDR_c; cd05233
568819001417	NAD(P) binding site [chemical binding]; other site
568819001418	active site
568819001420	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
568819001421	Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871
568819001422	RHS Repeat; Region: RHS_repeat; pfam05593
568819001423	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
568819001424	RHS Repeat; Region: RHS_repeat; pfam05593
568819001425	RHS Repeat; Region: RHS_repeat; pfam05593
568819001426	RHS Repeat; Region: RHS_repeat; pfam05593
568819001427	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
568819001429	HEAT repeats; Region: HEAT_2; pfam13646
568819001430	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001431	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001432	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819001433	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001434	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001435	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001436	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001437	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001438	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001439	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001440	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001441	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001442	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001443	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
568819001444	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819001445	Leucine rich repeat; Region: LRR_8; pfam13855
568819001446	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819001447	Leucine rich repeat; Region: LRR_8; pfam13855
568819001448	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001449	LRR adjacent; Region: LRR_adjacent; pfam08191
568819001450	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001451	SH3-like domain; Region: SH3_8; pfam13457
568819001452	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819001453	Transcriptional regulator; Region: Rrf2; pfam02082
568819001454	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819001455	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
568819001456	NAD(P) binding site [chemical binding]; other site
568819001457	active site
568819001458	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
568819001459	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
568819001460	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
568819001461	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568819001462	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819001463	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568819001464	Transcriptional regulator [Transcription]; Region: LytR; COG1316
568819001465	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
568819001466	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
568819001467	Predicted membrane protein [Function unknown]; Region: COG3619
568819001468	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
568819001469	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
568819001470	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
568819001471	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
568819001472	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
568819001473	Protein of unknown function DUF58; Region: DUF58; pfam01882
568819001474	MoxR-like ATPases [General function prediction only]; Region: COG0714
568819001475	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819001476	Walker A motif; other site
568819001477	ATP binding site [chemical binding]; other site
568819001478	Walker B motif; other site
568819001479	arginine finger; other site
568819001480	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
568819001481	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
568819001482	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
568819001483	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
568819001484	Na binding site [ion binding]; other site
568819001485	Uncharacterized conserved protein [Function unknown]; Region: COG3535
568819001486	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
568819001487	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819001488	nucleotide binding site [chemical binding]; other site
568819001489	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
568819001490	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819001491	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001492	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001493	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001494	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001495	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001496	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001497	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001498	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001499	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001500	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001501	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001502	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001503	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001504	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001505	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001506	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001507	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001508	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001509	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001510	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001511	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001512	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819001513	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001514	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001515	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001516	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819001517	Leucine rich repeat; Region: LRR_8; pfam13855
568819001518	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819001519	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819001520	Zn2+ binding site [ion binding]; other site
568819001521	Mg2+ binding site [ion binding]; other site
568819001522	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
568819001523	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
568819001524	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
568819001525	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819001526	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
568819001527	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
568819001528	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568819001529	FeS/SAM binding site; other site
568819001530	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
568819001531	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
568819001532	LXG domain of WXG superfamily; Region: LXG; pfam04740
568819001533	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
568819001534	putative FMN binding site [chemical binding]; other site
568819001535	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
568819001536	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568819001537	nudix motif; other site
568819001538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819001540	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819001541	putative dimerization interface [polypeptide binding]; other site
568819001542	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568819001543	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
568819001544	active site
568819001545	FMN binding site [chemical binding]; other site
568819001546	substrate binding site [chemical binding]; other site
568819001547	putative catalytic residue [active]
568819001548	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
568819001549	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819001550	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819001551	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
568819001552	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819001553	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819001554	shikimate binding site; other site
568819001555	NAD(P) binding site [chemical binding]; other site
568819001556	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
568819001557	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
568819001558	active site
568819001559	catalytic residue [active]
568819001560	dimer interface [polypeptide binding]; other site
568819001561	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819001562	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819001563	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
568819001564	dimerization interface [polypeptide binding]; other site
568819001565	substrate binding pocket [chemical binding]; other site
568819001566	Predicted acyl esterases [General function prediction only]; Region: COG2936
568819001567	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
568819001568	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
568819001569	active site
568819001570	catalytic triad [active]
568819001571	oxyanion hole [active]
568819001572	EamA-like transporter family; Region: EamA; pfam00892
568819001573	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
568819001574	EamA-like transporter family; Region: EamA; pfam00892
568819001575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
568819001576	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
568819001577	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819001578	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568819001579	substrate binding site [chemical binding]; other site
568819001580	hexamer interface [polypeptide binding]; other site
568819001581	metal binding site [ion binding]; metal-binding site
568819001582	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
568819001583	catalytic residue [active]
568819001584	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819001585	PRD domain; Region: PRD; pfam00874
568819001586	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819001587	active site
568819001588	P-loop; other site
568819001589	phosphorylation site [posttranslational modification]
568819001590	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001591	active site
568819001592	phosphorylation site [posttranslational modification]
568819001593	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
568819001594	putative active site [active]
568819001595	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819001596	active site
568819001597	phosphorylation site [posttranslational modification]
568819001598	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819001599	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568819001600	substrate binding site [chemical binding]; other site
568819001601	hexamer interface [polypeptide binding]; other site
568819001602	metal binding site [ion binding]; metal-binding site
568819001603	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819001604	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
568819001605	putative NAD(P) binding site [chemical binding]; other site
568819001606	catalytic Zn binding site [ion binding]; other site
568819001607	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819001608	active site
568819001609	P-loop; other site
568819001610	phosphorylation site [posttranslational modification]
568819001611	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
568819001612	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819001613	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
568819001614	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
568819001615	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819001616	active site
568819001617	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
568819001618	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
568819001619	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
568819001620	catalytic triad [active]
568819001621	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
568819001622	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819001623	MarR family; Region: MarR_2; pfam12802
568819001624	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001625	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001626	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819001627	Ligand Binding Site [chemical binding]; other site
568819001628	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
568819001629	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
568819001630	putative active site [active]
568819001631	putative metal binding site [ion binding]; other site
568819001632	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001633	catalytic core [active]
568819001634	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001635	Predicted membrane protein [Function unknown]; Region: COG3759
568819001636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819001637	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819001638	putative substrate translocation pore; other site
568819001639	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
568819001640	non-specific DNA interactions [nucleotide binding]; other site
568819001641	DNA binding site [nucleotide binding]
568819001642	sequence specific DNA binding site [nucleotide binding]; other site
568819001643	putative cAMP binding site [chemical binding]; other site
568819001644	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819001645	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568819001646	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
568819001647	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
568819001648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819001649	ATP binding site [chemical binding]; other site
568819001650	putative Mg++ binding site [ion binding]; other site
568819001651	HsdM N-terminal domain; Region: HsdM_N; pfam12161
568819001652	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
568819001653	Methyltransferase domain; Region: Methyltransf_26; pfam13659
568819001654	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
568819001655	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001656	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
568819001657	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
568819001658	Int/Topo IB signature motif; other site
568819001659	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
568819001660	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001661	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
568819001662	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819001663	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
568819001664	NAD binding site [chemical binding]; other site
568819001665	sugar binding site [chemical binding]; other site
568819001666	divalent metal binding site [ion binding]; other site
568819001667	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819001668	dimer interface [polypeptide binding]; other site
568819001669	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819001670	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819001671	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819001672	putative active site [active]
568819001673	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
568819001674	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
568819001675	Sulfate transporter family; Region: Sulfate_transp; pfam00916
568819001676	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568819001677	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
568819001678	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568819001679	DNA binding residues [nucleotide binding]
568819001680	dimer interface [polypeptide binding]; other site
568819001681	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
568819001682	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
568819001683	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
568819001684	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
568819001685	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
568819001686	DXD motif; other site
568819001687	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
568819001688	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
568819001689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568819001690	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819001691	S-adenosylmethionine binding site [chemical binding]; other site
568819001692	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
568819001693	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
568819001694	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819001695	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819001696	DNA binding site [nucleotide binding]
568819001697	domain linker motif; other site
568819001698	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819001699	putative dimerization interface [polypeptide binding]; other site
568819001700	putative ligand binding site [chemical binding]; other site
568819001701	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819001702	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
568819001703	NAD binding site [chemical binding]; other site
568819001704	sugar binding site [chemical binding]; other site
568819001705	divalent metal binding site [ion binding]; other site
568819001706	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819001707	dimer interface [polypeptide binding]; other site
568819001708	allantoate amidohydrolase; Reviewed; Region: PRK09290
568819001709	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
568819001710	active site
568819001711	metal binding site [ion binding]; metal-binding site
568819001712	dimer interface [polypeptide binding]; other site
568819001713	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819001714	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
568819001715	metal binding site [ion binding]; metal-binding site
568819001716	putative dimer interface [polypeptide binding]; other site
568819001717	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
568819001718	Beta-lactamase; Region: Beta-lactamase; pfam00144
568819001719	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568819001720	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568819001721	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819001722	intersubunit interface [polypeptide binding]; other site
568819001723	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
568819001724	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
568819001725	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
568819001726	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
568819001727	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
568819001728	Glucitol operon activator protein (GutM); Region: GutM; cl01890
568819001729	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
568819001730	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819001731	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
568819001732	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819001733	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819001734	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819001735	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
568819001736	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001737	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001738	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001739	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819001740	WxL domain surface cell wall-binding; Region: WxL; pfam13731
568819001741	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
568819001742	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
568819001743	FOG: CBS domain [General function prediction only]; Region: COG0517
568819001744	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
568819001745	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
568819001746	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
568819001747	dimer interface [polypeptide binding]; other site
568819001748	active site
568819001749	metal binding site [ion binding]; metal-binding site
568819001750	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
568819001751	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819001752	putative substrate translocation pore; other site
568819001753	POT family; Region: PTR2; pfam00854
568819001754	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001755	catalytic core [active]
568819001756	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001757	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001758	catalytic core [active]
568819001759	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819001760	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
568819001761	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
568819001762	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
568819001763	Cl binding site [ion binding]; other site
568819001764	oligomer interface [polypeptide binding]; other site
568819001765	glutamate dehydrogenase; Provisional; Region: PRK09414
568819001766	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
568819001767	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
568819001768	NAD(P) binding site [chemical binding]; other site
568819001769	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
568819001770	metal binding site [ion binding]; metal-binding site
568819001771	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
568819001772	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
568819001773	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
568819001774	substrate binding site [chemical binding]; other site
568819001775	glutamase interaction surface [polypeptide binding]; other site
568819001776	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
568819001777	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
568819001778	catalytic residues [active]
568819001779	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
568819001780	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
568819001781	putative active site [active]
568819001782	oxyanion strand; other site
568819001783	catalytic triad [active]
568819001784	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
568819001785	putative active site pocket [active]
568819001786	4-fold oligomerization interface [polypeptide binding]; other site
568819001787	metal binding residues [ion binding]; metal-binding site
568819001788	3-fold/trimer interface [polypeptide binding]; other site
568819001789	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
568819001790	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
568819001791	NAD binding site [chemical binding]; other site
568819001792	dimerization interface [polypeptide binding]; other site
568819001793	product binding site; other site
568819001794	substrate binding site [chemical binding]; other site
568819001795	zinc binding site [ion binding]; other site
568819001796	catalytic residues [active]
568819001797	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
568819001798	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
568819001799	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
568819001800	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
568819001801	dimer interface [polypeptide binding]; other site
568819001802	motif 1; other site
568819001803	active site
568819001804	motif 2; other site
568819001805	motif 3; other site
568819001806	histidinol-phosphatase; Reviewed; Region: PRK08123
568819001807	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
568819001808	active site
568819001809	dimer interface [polypeptide binding]; other site
568819001810	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
568819001811	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819001812	DNA binding site [nucleotide binding]
568819001813	active site
568819001814	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
568819001815	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568819001816	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819001817	beta-galactosidase; Region: BGL; TIGR03356
568819001818	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819001819	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001820	DNA-binding site [nucleotide binding]; DNA binding site
568819001821	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568819001822	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001823	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819001824	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
568819001825	Uncharacterized conserved protein [Function unknown]; Region: COG2966
568819001826	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
568819001827	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
568819001828	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
568819001829	Predicted esterase [General function prediction only]; Region: COG0400
568819001830	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
568819001831	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
568819001832	putative RNA binding site [nucleotide binding]; other site
568819001833	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819001834	S-adenosylmethionine binding site [chemical binding]; other site
568819001835	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
568819001836	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819001837	Bacterial SH3 domain; Region: SH3_3; pfam08239
568819001838	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819001839	NlpC/P60 family; Region: NLPC_P60; pfam00877
568819001840	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
568819001841	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
568819001842	ATP binding site [chemical binding]; other site
568819001843	putative Mg++ binding site [ion binding]; other site
568819001844	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
568819001845	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
568819001846	nucleotide binding region [chemical binding]; other site
568819001847	ATP-binding site [chemical binding]; other site
568819001848	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819001849	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568819001850	WxL domain surface cell wall-binding; Region: WxL; pfam13731
568819001851	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
568819001852	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
568819001853	UreD urease accessory protein; Region: UreD; cl00530
568819001854	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
568819001855	DNA photolyase; Region: DNA_photolyase; pfam00875
568819001856	Predicted membrane protein [Function unknown]; Region: COG4852
568819001857	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
568819001858	DAK2 domain; Region: Dak2; pfam02734
568819001859	EDD domain protein, DegV family; Region: DegV; TIGR00762
568819001860	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568819001861	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
568819001862	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
568819001863	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
568819001864	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
568819001865	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
568819001866	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819001867	homodimer interface [polypeptide binding]; other site
568819001868	substrate-cofactor binding pocket; other site
568819001869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819001870	catalytic residue [active]
568819001871	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
568819001872	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819001873	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819001874	ligand binding site [chemical binding]; other site
568819001875	flexible hinge region; other site
568819001876	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819001877	BioY family; Region: BioY; pfam02632
568819001878	Predicted transcriptional regulators [Transcription]; Region: COG1695
568819001879	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568819001880	Predicted membrane protein [Function unknown]; Region: COG4709
568819001881	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819001882	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568819001883	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568819001884	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568819001885	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568819001886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819001887	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568819001888	Coenzyme A binding pocket [chemical binding]; other site
568819001889	Tic20-like protein; Region: Tic20; pfam09685
568819001890	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
568819001891	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819001892	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819001893	MarR family; Region: MarR_2; pfam12802
568819001894	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819001895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819001896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819001897	Walker A/P-loop; other site
568819001898	ATP binding site [chemical binding]; other site
568819001899	Q-loop/lid; other site
568819001900	ABC transporter signature motif; other site
568819001901	Walker B; other site
568819001902	D-loop; other site
568819001903	H-loop/switch region; other site
568819001904	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819001905	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819001906	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
568819001907	Walker A/P-loop; other site
568819001908	ATP binding site [chemical binding]; other site
568819001909	Q-loop/lid; other site
568819001910	ABC transporter signature motif; other site
568819001911	Walker B; other site
568819001912	D-loop; other site
568819001913	H-loop/switch region; other site
568819001914	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568819001915	active site residue [active]
568819001916	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819001917	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
568819001918	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568819001919	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819001920	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819001921	putative DNA binding site [nucleotide binding]; other site
568819001922	putative Zn2+ binding site [ion binding]; other site
568819001923	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
568819001924	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
568819001925	putative NAD(P) binding site [chemical binding]; other site
568819001926	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
568819001927	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568819001928	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
568819001929	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568819001930	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
568819001931	putative active site [active]
568819001932	catalytic site [active]
568819001933	putative metal binding site [ion binding]; other site
568819001934	Catalytic domain of Protein Kinases; Region: PKc; cd00180
568819001935	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
568819001936	active site
568819001937	ATP binding site [chemical binding]; other site
568819001938	substrate binding site [chemical binding]; other site
568819001939	activation loop (A-loop); other site
568819001940	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
568819001941	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
568819001942	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819001943	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568819001944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819001945	Coenzyme A binding pocket [chemical binding]; other site
568819001946	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
568819001947	active site
568819001948	catalytic triad [active]
568819001949	oxyanion hole [active]
568819001950	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
568819001951	domain interaction interfaces [polypeptide binding]; other site
568819001952	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
568819001953	domain interaction interfaces [polypeptide binding]; other site
568819001954	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
568819001955	domain interaction interfaces [polypeptide binding]; other site
568819001956	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
568819001957	domain interaction interfaces [polypeptide binding]; other site
568819001958	Isochorismatase family; Region: Isochorismatase; pfam00857
568819001959	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
568819001960	catalytic triad [active]
568819001961	conserved cis-peptide bond; other site
568819001962	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
568819001963	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819001964	motif II; other site
568819001965	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819001966	Transcriptional regulator; Region: Rrf2; pfam02082
568819001967	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819001968	S-adenosylmethionine binding site [chemical binding]; other site
568819001969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
568819001970	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568819001971	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819001972	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819001973	active site
568819001974	catalytic tetrad [active]
568819001975	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
568819001976	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819001977	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819001978	motif II; other site
568819001979	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
568819001980	catalytic residue [active]
568819001981	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568819001982	Sulfatase; Region: Sulfatase; pfam00884
568819001983	amino acid transporter; Region: 2A0306; TIGR00909
568819001984	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
568819001985	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
568819001986	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
568819001987	putative metal binding site [ion binding]; other site
568819001988	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
568819001989	active site
568819001990	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
568819001991	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
568819001992	Cl binding site [ion binding]; other site
568819001993	oligomer interface [polypeptide binding]; other site
568819001994	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819001995	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819001996	DNA-binding site [nucleotide binding]; DNA binding site
568819001997	Predicted membrane protein [Function unknown]; Region: COG1511
568819001998	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819001999	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002000	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819002001	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002002	DNA-binding site [nucleotide binding]; DNA binding site
568819002003	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568819002004	Predicted integral membrane protein [Function unknown]; Region: COG5523
568819002005	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819002006	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
568819002007	active site
568819002008	metal binding site [ion binding]; metal-binding site
568819002009	Predicted membrane protein [Function unknown]; Region: COG2322
568819002010	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
568819002011	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
568819002012	cofactor binding site; other site
568819002013	DNA binding site [nucleotide binding]
568819002014	substrate interaction site [chemical binding]; other site
568819002015	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
568819002016	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
568819002017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568819002018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002019	ATP binding site [chemical binding]; other site
568819002020	Mg2+ binding site [ion binding]; other site
568819002021	G-X-G motif; other site
568819002022	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
568819002023	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819002024	minor groove reading motif; other site
568819002025	helix-hairpin-helix signature motif; other site
568819002026	substrate binding pocket [chemical binding]; other site
568819002027	active site
568819002028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819002029	non-specific DNA binding site [nucleotide binding]; other site
568819002030	salt bridge; other site
568819002031	sequence-specific DNA binding site [nucleotide binding]; other site
568819002032	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
568819002033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
568819002034	Transposase; Region: HTH_Tnp_1; cl17663
568819002035	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819002036	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002037	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002038	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
568819002039	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
568819002040	dimer interface [polypeptide binding]; other site
568819002041	substrate binding site [chemical binding]; other site
568819002042	ATP binding site [chemical binding]; other site
568819002043	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819002044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819002045	active site
568819002046	motif I; other site
568819002047	motif II; other site
568819002048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819002049	maltose O-acetyltransferase; Provisional; Region: PRK10092
568819002050	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
568819002051	active site
568819002052	substrate binding site [chemical binding]; other site
568819002053	trimer interface [polypeptide binding]; other site
568819002054	CoA binding site [chemical binding]; other site
568819002055	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
568819002056	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819002057	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
568819002058	Walker A/P-loop; other site
568819002059	ATP binding site [chemical binding]; other site
568819002060	Q-loop/lid; other site
568819002061	ABC transporter signature motif; other site
568819002062	Walker B; other site
568819002063	D-loop; other site
568819002064	H-loop/switch region; other site
568819002065	inner membrane transport permease; Provisional; Region: PRK15066
568819002066	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568819002067	oxidoreductase; Provisional; Region: PRK07985
568819002068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002069	NAD(P) binding site [chemical binding]; other site
568819002070	active site
568819002071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
568819002072	Predicted membrane protein [Function unknown]; Region: COG3152
568819002073	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
568819002074	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
568819002075	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
568819002076	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
568819002077	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
568819002078	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
568819002079	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
568819002080	FHIPEP family; Region: FHIPEP; pfam00771
568819002081	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
568819002082	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568819002083	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
568819002084	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568819002085	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
568819002086	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
568819002087	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
568819002088	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
568819002089	flagellar motor protein MotA; Validated; Region: PRK08124
568819002090	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
568819002091	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
568819002092	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
568819002093	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
568819002094	ligand binding site [chemical binding]; other site
568819002095	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568819002096	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
568819002097	putative metal binding site; other site
568819002098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819002099	binding surface
568819002100	TPR motif; other site
568819002101	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
568819002102	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
568819002103	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819002104	active site
568819002105	phosphorylation site [posttranslational modification]
568819002106	intermolecular recognition site; other site
568819002107	dimerization interface [polypeptide binding]; other site
568819002108	flagellin; Provisional; Region: PRK12805
568819002109	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568819002110	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
568819002111	Response regulator receiver domain; Region: Response_reg; pfam00072
568819002112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819002113	active site
568819002114	phosphorylation site [posttranslational modification]
568819002115	intermolecular recognition site; other site
568819002116	dimerization interface [polypeptide binding]; other site
568819002117	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
568819002118	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
568819002119	putative binding surface; other site
568819002120	active site
568819002121	P2 response regulator binding domain; Region: P2; pfam07194
568819002122	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
568819002123	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002124	ATP binding site [chemical binding]; other site
568819002125	Mg2+ binding site [ion binding]; other site
568819002126	G-X-G motif; other site
568819002127	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
568819002128	flagellar motor switch protein; Validated; Region: PRK06788
568819002129	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
568819002130	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
568819002131	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
568819002132	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
568819002133	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
568819002134	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
568819002135	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568819002136	flagellar motor switch protein; Validated; Region: PRK06789
568819002137	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
568819002138	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
568819002139	flagellar motor switch protein; Reviewed; Region: PRK06782
568819002140	CheC-like family; Region: CheC; pfam04509
568819002141	CheC-like family; Region: CheC; pfam04509
568819002142	Chemotaxis phosphatase CheX; Region: CheX; cl15816
568819002143	CheC-like family; Region: CheC; pfam04509
568819002144	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
568819002145	Protein of unknown function (DUF327); Region: DUF327; pfam03885
568819002146	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
568819002147	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568819002148	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
568819002149	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
568819002150	flagellar capping protein; Validated; Region: fliD; PRK06798
568819002151	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
568819002152	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
568819002153	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
568819002154	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
568819002155	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
568819002156	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
568819002157	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
568819002158	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
568819002159	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
568819002160	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
568819002161	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
568819002162	FliG C-terminal domain; Region: FliG_C; pfam01706
568819002163	flagellar assembly protein H; Validated; Region: fliH; PRK06800
568819002164	Flagellar assembly protein FliH; Region: FliH; pfam02108
568819002165	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
568819002166	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568819002167	Walker A motif; other site
568819002168	ATP binding site [chemical binding]; other site
568819002169	Walker B motif; other site
568819002170	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
568819002171	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
568819002172	N-acetyl-D-glucosamine binding site [chemical binding]; other site
568819002173	catalytic residue [active]
568819002174	Predicted transcriptional regulators [Transcription]; Region: COG1695
568819002175	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
568819002176	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
568819002177	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
568819002178	pyruvate oxidase; Provisional; Region: PRK08611
568819002179	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
568819002180	PYR/PP interface [polypeptide binding]; other site
568819002181	dimer interface [polypeptide binding]; other site
568819002182	tetramer interface [polypeptide binding]; other site
568819002183	TPP binding site [chemical binding]; other site
568819002184	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819002185	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
568819002186	TPP-binding site [chemical binding]; other site
568819002187	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
568819002188	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568819002189	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819002190	dimerization interface [polypeptide binding]; other site
568819002191	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568819002192	dimer interface [polypeptide binding]; other site
568819002193	putative CheW interface [polypeptide binding]; other site
568819002194	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
568819002195	putative active site [active]
568819002196	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
568819002197	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
568819002198	glutaminase active site [active]
568819002199	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819002200	dimer interface [polypeptide binding]; other site
568819002201	active site
568819002202	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819002203	dimer interface [polypeptide binding]; other site
568819002204	active site
568819002205	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
568819002206	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
568819002207	active site
568819002208	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
568819002209	GIY-YIG motif/motif A; other site
568819002210	Leucine rich repeat; Region: LRR_8; pfam13855
568819002211	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002212	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002213	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002214	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568819002215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819002216	non-specific DNA binding site [nucleotide binding]; other site
568819002217	salt bridge; other site
568819002218	sequence-specific DNA binding site [nucleotide binding]; other site
568819002220	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819002221	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819002222	ligand binding site [chemical binding]; other site
568819002223	flexible hinge region; other site
568819002224	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819002225	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002226	DNA-binding site [nucleotide binding]; DNA binding site
568819002227	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819002228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819002229	Walker A/P-loop; other site
568819002230	ATP binding site [chemical binding]; other site
568819002231	Q-loop/lid; other site
568819002232	ABC transporter signature motif; other site
568819002233	Walker B; other site
568819002234	D-loop; other site
568819002235	H-loop/switch region; other site
568819002236	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819002237	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819002238	Walker A/P-loop; other site
568819002239	ATP binding site [chemical binding]; other site
568819002240	Q-loop/lid; other site
568819002241	ABC transporter signature motif; other site
568819002242	Walker B; other site
568819002243	D-loop; other site
568819002244	H-loop/switch region; other site
568819002245	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
568819002246	FtsX-like permease family; Region: FtsX; pfam02687
568819002247	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568819002248	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819002249	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
568819002250	ligand binding site [chemical binding]; other site
568819002251	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
568819002252	non-specific DNA interactions [nucleotide binding]; other site
568819002253	DNA binding site [nucleotide binding]
568819002254	sequence specific DNA binding site [nucleotide binding]; other site
568819002255	putative cAMP binding site [chemical binding]; other site
568819002256	SnoaL-like domain; Region: SnoaL_4; pfam13577
568819002257	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
568819002258	active site
568819002259	catalytic triad [active]
568819002260	oxyanion hole [active]
568819002261	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819002262	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819002263	Walker A/P-loop; other site
568819002264	ATP binding site [chemical binding]; other site
568819002265	Q-loop/lid; other site
568819002266	ABC transporter signature motif; other site
568819002267	Walker B; other site
568819002268	D-loop; other site
568819002269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819002270	H-loop/switch region; other site
568819002271	active site
568819002272	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
568819002273	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568819002274	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819002275	Zn binding site [ion binding]; other site
568819002276	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819002277	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819002278	Zn binding site [ion binding]; other site
568819002279	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
568819002280	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819002281	Zn binding site [ion binding]; other site
568819002282	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
568819002283	Zn binding site [ion binding]; other site
568819002284	Predicted esterase [General function prediction only]; Region: COG0400
568819002285	putative hydrolase; Provisional; Region: PRK11460
568819002286	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
568819002287	GTPases [General function prediction only]; Region: HflX; COG2262
568819002288	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
568819002289	HflX GTPase family; Region: HflX; cd01878
568819002290	G1 box; other site
568819002291	GTP/Mg2+ binding site [chemical binding]; other site
568819002292	Switch I region; other site
568819002293	G2 box; other site
568819002294	G3 box; other site
568819002295	Switch II region; other site
568819002296	G4 box; other site
568819002297	G5 box; other site
568819002298	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568819002299	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819002300	putative active site [active]
568819002301	putative metal binding site [ion binding]; other site
568819002302	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
568819002303	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568819002304	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
568819002305	Uncharacterized conserved protein [Function unknown]; Region: COG3538
568819002306	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
568819002307	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
568819002308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002309	putative PBP binding loops; other site
568819002310	ABC-ATPase subunit interface; other site
568819002311	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819002312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002313	dimer interface [polypeptide binding]; other site
568819002314	conserved gate region; other site
568819002315	putative PBP binding loops; other site
568819002316	ABC-ATPase subunit interface; other site
568819002317	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819002318	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
568819002319	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
568819002320	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002321	DNA-binding site [nucleotide binding]; DNA binding site
568819002322	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819002323	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819002324	ligand binding site [chemical binding]; other site
568819002325	dimerization interface [polypeptide binding]; other site
568819002326	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819002327	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002328	DNA-binding site [nucleotide binding]; DNA binding site
568819002329	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
568819002330	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
568819002331	putative NADP binding site [chemical binding]; other site
568819002332	putative dimer interface [polypeptide binding]; other site
568819002333	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
568819002334	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
568819002335	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819002336	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819002337	nucleotide binding site [chemical binding]; other site
568819002338	Predicted membrane protein [Function unknown]; Region: COG4811
568819002339	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
568819002340	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
568819002341	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
568819002342	active site
568819002343	phosphorylation site [posttranslational modification]
568819002344	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819002345	active pocket/dimerization site; other site
568819002346	active site
568819002347	phosphorylation site [posttranslational modification]
568819002348	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
568819002349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819002350	Walker A motif; other site
568819002351	ATP binding site [chemical binding]; other site
568819002352	Walker B motif; other site
568819002353	arginine finger; other site
568819002354	Transcriptional antiterminator [Transcription]; Region: COG3933
568819002355	PRD domain; Region: PRD; pfam00874
568819002356	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819002357	active pocket/dimerization site; other site
568819002358	active site
568819002359	phosphorylation site [posttranslational modification]
568819002360	PRD domain; Region: PRD; pfam00874
568819002361	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
568819002362	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568819002363	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
568819002364	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
568819002365	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
568819002366	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
568819002367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
568819002368	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
568819002369	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
568819002370	Leucine rich repeat; Region: LRR_8; pfam13855
568819002371	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002372	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002373	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002374	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002375	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002376	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819002377	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
568819002378	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568819002379	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
568819002380	putative deacylase active site [active]
568819002381	Predicted amidohydrolase [General function prediction only]; Region: COG0388
568819002382	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
568819002383	active site
568819002384	catalytic triad [active]
568819002385	dimer interface [polypeptide binding]; other site
568819002386	Protein of unknown function (DUF554); Region: DUF554; pfam04474
568819002387	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
568819002388	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568819002389	NAD binding site [chemical binding]; other site
568819002390	substrate binding site [chemical binding]; other site
568819002391	putative active site [active]
568819002392	Predicted permeases [General function prediction only]; Region: RarD; COG2962
568819002393	EamA-like transporter family; Region: EamA; pfam00892
568819002394	Uncharacterized conserved protein [Function unknown]; Region: COG2353
568819002395	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819002396	MarR family; Region: MarR_2; pfam12802
568819002397	lysine transporter; Provisional; Region: PRK10836
568819002398	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568819002399	PAS domain; Region: PAS_9; pfam13426
568819002400	putative active site [active]
568819002401	heme pocket [chemical binding]; other site
568819002402	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
568819002404	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819002405	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568819002406	synthetase active site [active]
568819002407	NTP binding site [chemical binding]; other site
568819002408	metal binding site [ion binding]; metal-binding site
568819002409	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
568819002410	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
568819002411	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819002412	non-specific DNA binding site [nucleotide binding]; other site
568819002413	salt bridge; other site
568819002414	sequence-specific DNA binding site [nucleotide binding]; other site
568819002415	Cupin domain; Region: Cupin_2; pfam07883
568819002416	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
568819002417	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
568819002418	Walker A/P-loop; other site
568819002419	ATP binding site [chemical binding]; other site
568819002420	Q-loop/lid; other site
568819002421	ABC transporter signature motif; other site
568819002422	Walker B; other site
568819002423	D-loop; other site
568819002424	H-loop/switch region; other site
568819002425	TOBE domain; Region: TOBE_2; pfam08402
568819002426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002427	dimer interface [polypeptide binding]; other site
568819002428	conserved gate region; other site
568819002429	putative PBP binding loops; other site
568819002430	ABC-ATPase subunit interface; other site
568819002431	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
568819002432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002433	dimer interface [polypeptide binding]; other site
568819002434	conserved gate region; other site
568819002435	putative PBP binding loops; other site
568819002436	ABC-ATPase subunit interface; other site
568819002437	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
568819002438	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
568819002439	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
568819002440	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
568819002441	active site
568819002442	zinc binding site [ion binding]; other site
568819002443	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568819002444	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819002445	Zn2+ binding site [ion binding]; other site
568819002446	Mg2+ binding site [ion binding]; other site
568819002447	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819002448	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819002449	nucleotide binding site [chemical binding]; other site
568819002450	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
568819002451	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
568819002452	FMN binding site [chemical binding]; other site
568819002453	substrate binding site [chemical binding]; other site
568819002454	putative catalytic residue [active]
568819002455	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
568819002456	LXG domain of WXG superfamily; Region: LXG; pfam04740
568819002457	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819002458	dimer interface [polypeptide binding]; other site
568819002459	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819002460	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
568819002461	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568819002462	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819002463	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
568819002464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819002465	motif II; other site
568819002466	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819002467	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819002468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819002469	Coenzyme A binding pocket [chemical binding]; other site
568819002470	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
568819002471	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819002472	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819002473	DNA binding residues [nucleotide binding]
568819002474	putative dimer interface [polypeptide binding]; other site
568819002475	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819002476	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819002477	active site
568819002478	catalytic tetrad [active]
568819002479	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
568819002480	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
568819002481	homodimer interface [polypeptide binding]; other site
568819002482	catalytic residues [active]
568819002483	NAD binding site [chemical binding]; other site
568819002484	substrate binding pocket [chemical binding]; other site
568819002485	flexible flap; other site
568819002486	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
568819002487	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568819002488	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
568819002489	PhoU domain; Region: PhoU; pfam01895
568819002490	PhoU domain; Region: PhoU; pfam01895
568819002491	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
568819002492	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
568819002493	dimer interface [polypeptide binding]; other site
568819002494	PYR/PP interface [polypeptide binding]; other site
568819002495	TPP binding site [chemical binding]; other site
568819002496	substrate binding site [chemical binding]; other site
568819002497	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
568819002498	Domain of unknown function; Region: EKR; smart00890
568819002499	4Fe-4S binding domain; Region: Fer4_6; pfam12837
568819002500	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
568819002501	TPP-binding site [chemical binding]; other site
568819002502	dimer interface [polypeptide binding]; other site
568819002503	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
568819002504	Predicted permeases [General function prediction only]; Region: COG0679
568819002505	Helix-turn-helix domain; Region: HTH_28; pfam13518
568819002506	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819002507	non-specific DNA binding site [nucleotide binding]; other site
568819002508	salt bridge; other site
568819002509	sequence-specific DNA binding site [nucleotide binding]; other site
568819002510	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
568819002511	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002512	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819002513	Predicted membrane protein [Function unknown]; Region: COG3223
568819002514	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819002515	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819002516	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
568819002517	Walker A/P-loop; other site
568819002518	ATP binding site [chemical binding]; other site
568819002519	Q-loop/lid; other site
568819002520	ABC transporter signature motif; other site
568819002521	Walker B; other site
568819002522	D-loop; other site
568819002523	H-loop/switch region; other site
568819002524	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
568819002525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002526	putative substrate translocation pore; other site
568819002527	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002528	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002529	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819002530	putative substrate translocation pore; other site
568819002531	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819002532	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819002533	putative DNA binding site [nucleotide binding]; other site
568819002534	putative Zn2+ binding site [ion binding]; other site
568819002535	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
568819002536	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
568819002537	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819002538	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
568819002539	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819002540	motif II; other site
568819002541	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819002542	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002543	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002544	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002545	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002546	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002547	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002548	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819002549	Predicted membrane protein [Function unknown]; Region: COG3326
568819002550	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
568819002551	homotrimer interaction site [polypeptide binding]; other site
568819002552	putative active site [active]
568819002553	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
568819002554	substrate binding site [chemical binding]; other site
568819002555	zinc-binding site [ion binding]; other site
568819002556	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
568819002557	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568819002558	GIY-YIG motif/motif A; other site
568819002559	active site
568819002560	catalytic site [active]
568819002561	putative DNA binding site [nucleotide binding]; other site
568819002562	metal binding site [ion binding]; metal-binding site
568819002563	UvrB/uvrC motif; Region: UVR; pfam02151
568819002564	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568819002565	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819002566	substrate binding pocket [chemical binding]; other site
568819002567	membrane-bound complex binding site; other site
568819002568	hinge residues; other site
568819002569	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819002570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002571	dimer interface [polypeptide binding]; other site
568819002572	conserved gate region; other site
568819002573	putative PBP binding loops; other site
568819002574	ABC-ATPase subunit interface; other site
568819002575	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819002576	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568819002577	Walker A/P-loop; other site
568819002578	ATP binding site [chemical binding]; other site
568819002579	Q-loop/lid; other site
568819002580	ABC transporter signature motif; other site
568819002581	Walker B; other site
568819002582	D-loop; other site
568819002583	H-loop/switch region; other site
568819002584	amidase; Provisional; Region: PRK11910
568819002585	Amidase; Region: Amidase; cl11426
568819002586	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819002587	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819002588	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568819002589	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
568819002590	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
568819002591	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
568819002592	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
568819002593	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
568819002594	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819002595	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819002596	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
568819002597	Esterase/lipase [General function prediction only]; Region: COG1647
568819002598	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819002599	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819002600	DNA binding site [nucleotide binding]
568819002601	domain linker motif; other site
568819002602	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
568819002603	putative dimerization interface [polypeptide binding]; other site
568819002604	putative ligand binding site [chemical binding]; other site
568819002605	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819002606	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819002607	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
568819002608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002609	dimer interface [polypeptide binding]; other site
568819002610	conserved gate region; other site
568819002611	putative PBP binding loops; other site
568819002612	ABC-ATPase subunit interface; other site
568819002613	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819002614	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819002615	dimer interface [polypeptide binding]; other site
568819002616	conserved gate region; other site
568819002617	ABC-ATPase subunit interface; other site
568819002618	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819002619	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568819002620	Ca binding site [ion binding]; other site
568819002621	active site
568819002622	catalytic site [active]
568819002623	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
568819002624	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
568819002625	active site
568819002626	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
568819002627	active site
568819002628	substrate binding site [chemical binding]; other site
568819002629	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
568819002630	metal binding site [ion binding]; metal-binding site
568819002631	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568819002632	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819002633	ATP binding site [chemical binding]; other site
568819002634	Mg++ binding site [ion binding]; other site
568819002635	motif III; other site
568819002636	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819002637	nucleotide binding region [chemical binding]; other site
568819002638	ATP-binding site [chemical binding]; other site
568819002639	Predicted membrane protein [Function unknown]; Region: COG4708
568819002640	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
568819002641	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367
568819002642	Predicted transcriptional regulators [Transcription]; Region: COG1733
568819002643	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
568819002644	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
568819002645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002646	putative substrate translocation pore; other site
568819002647	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819002648	PRD domain; Region: PRD; pfam00874
568819002649	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819002650	active site
568819002651	P-loop; other site
568819002652	phosphorylation site [posttranslational modification]
568819002653	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819002654	active site
568819002655	phosphorylation site [posttranslational modification]
568819002656	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819002657	methionine cluster; other site
568819002658	active site
568819002659	phosphorylation site [posttranslational modification]
568819002660	metal binding site [ion binding]; metal-binding site
568819002661	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819002662	active site
568819002663	P-loop; other site
568819002664	phosphorylation site [posttranslational modification]
568819002665	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819002666	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819002667	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
568819002668	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
568819002669	active site
568819002670	trimer interface [polypeptide binding]; other site
568819002671	allosteric site; other site
568819002672	active site lid [active]
568819002673	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819002674	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819002675	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819002676	active site
568819002677	catalytic tetrad [active]
568819002678	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
568819002679	Collagen binding domain; Region: Collagen_bind; pfam05737
568819002680	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819002681	Uncharacterized conserved protein [Function unknown]; Region: COG3402
568819002682	Predicted membrane protein [Function unknown]; Region: COG3428
568819002683	Bacterial PH domain; Region: DUF304; pfam03703
568819002684	Bacterial PH domain; Region: DUF304; pfam03703
568819002685	Bacterial PH domain; Region: DUF304; pfam03703
568819002686	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
568819002687	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
568819002688	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
568819002689	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
568819002690	active site
568819002691	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819002692	dimer interface [polypeptide binding]; other site
568819002693	substrate binding site [chemical binding]; other site
568819002694	catalytic residues [active]
568819002695	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
568819002696	PemK-like protein; Region: PemK; pfam02452
568819002697	Rsbr N terminal; Region: Rsbr_N; pfam08678
568819002698	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002699	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819002700	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
568819002701	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
568819002702	ATP binding site [chemical binding]; other site
568819002703	Mg2+ binding site [ion binding]; other site
568819002704	G-X-G motif; other site
568819002705	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
568819002706	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
568819002707	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
568819002708	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
568819002709	anti sigma factor interaction site; other site
568819002710	regulatory phosphorylation site [posttranslational modification]; other site
568819002711	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
568819002712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002713	ATP binding site [chemical binding]; other site
568819002714	Mg2+ binding site [ion binding]; other site
568819002715	G-X-G motif; other site
568819002716	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
568819002717	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819002718	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568819002719	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568819002720	DNA binding residues [nucleotide binding]
568819002721	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
568819002722	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
568819002723	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
568819002724	Sulfate transporter family; Region: Sulfate_transp; pfam00916
568819002725	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
568819002726	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
568819002727	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
568819002728	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
568819002729	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
568819002730	RNA binding site [nucleotide binding]; other site
568819002731	hypothetical protein; Provisional; Region: PRK04351
568819002732	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
568819002733	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
568819002734	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
568819002735	Uncharacterized conserved protein [Function unknown]; Region: COG5646
568819002736	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819002737	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819002738	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819002739	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002740	DNA-binding site [nucleotide binding]; DNA binding site
568819002741	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568819002744	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
568819002745	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
568819002746	glutathione reductase; Validated; Region: PRK06116
568819002747	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819002748	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819002749	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819002750	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819002751	catalytic core [active]
568819002752	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819002753	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568819002754	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819002755	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002756	DNA-binding site [nucleotide binding]; DNA binding site
568819002757	Predicted membrane protein [General function prediction only]; Region: COG4194
568819002758	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
568819002759	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
568819002760	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
568819002761	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
568819002762	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
568819002763	tetramerization interface [polypeptide binding]; other site
568819002764	NAD(P) binding site [chemical binding]; other site
568819002765	catalytic residues [active]
568819002766	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
568819002767	active site
568819002768	P-loop; other site
568819002769	phosphorylation site [posttranslational modification]
568819002770	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819002771	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819002772	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819002773	methionine cluster; other site
568819002774	active site
568819002775	phosphorylation site [posttranslational modification]
568819002776	metal binding site [ion binding]; metal-binding site
568819002777	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819002778	beta-galactosidase; Region: BGL; TIGR03356
568819002779	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819002780	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819002781	PRD domain; Region: PRD; pfam00874
568819002782	PRD domain; Region: PRD; pfam00874
568819002783	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819002784	active site
568819002785	phosphorylation site [posttranslational modification]
568819002786	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819002787	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819002788	ABC transporter; Region: ABC_tran_2; pfam12848
568819002789	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819002790	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
568819002791	Predicted permeases [General function prediction only]; Region: COG0701
568819002792	Predicted membrane protein [Function unknown]; Region: COG3689
568819002793	pantothenate kinase; Provisional; Region: PRK05439
568819002794	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
568819002795	ATP-binding site [chemical binding]; other site
568819002796	CoA-binding site [chemical binding]; other site
568819002797	Mg2+-binding site [ion binding]; other site
568819002798	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
568819002799	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819002800	Walker A/P-loop; other site
568819002801	ATP binding site [chemical binding]; other site
568819002802	Q-loop/lid; other site
568819002803	ABC transporter signature motif; other site
568819002804	Walker B; other site
568819002805	D-loop; other site
568819002806	H-loop/switch region; other site
568819002807	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568819002808	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568819002809	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819002810	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819002811	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
568819002812	Domain of unknown function (DUF373); Region: DUF373; cl12079
568819002813	Sulfatase; Region: Sulfatase; pfam00884
568819002814	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
568819002815	active site
568819002816	DNA binding site [nucleotide binding]
568819002817	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
568819002818	active site
568819002819	catalytic site [active]
568819002820	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
568819002821	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568819002822	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
568819002823	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
568819002824	Uncharacterized conserved protein [Function unknown]; Region: COG0398
568819002825	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568819002826	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
568819002827	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
568819002828	epoxyqueuosine reductase; Region: TIGR00276
568819002829	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
568819002830	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
568819002831	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
568819002832	dimer interface [polypeptide binding]; other site
568819002833	FMN binding site [chemical binding]; other site
568819002834	NADPH bind site [chemical binding]; other site
568819002835	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568819002836	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568819002837	active site
568819002838	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
568819002839	HSP90 family protein; Provisional; Region: PRK14083
568819002840	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819002841	ATP binding site [chemical binding]; other site
568819002842	Mg2+ binding site [ion binding]; other site
568819002843	G-X-G motif; other site
568819002844	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
568819002845	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
568819002846	dimerization interface [polypeptide binding]; other site
568819002847	DPS ferroxidase diiron center [ion binding]; other site
568819002848	ion pore; other site
568819002849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
568819002850	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
568819002851	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819002852	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
568819002853	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
568819002854	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
568819002855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002856	putative substrate translocation pore; other site
568819002857	Transcriptional regulators [Transcription]; Region: FadR; COG2186
568819002858	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002859	DNA-binding site [nucleotide binding]; DNA binding site
568819002860	FCD domain; Region: FCD; pfam07729
568819002861	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819002862	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568819002863	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
568819002864	PGAP1-like protein; Region: PGAP1; pfam07819
568819002865	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
568819002866	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
568819002867	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
568819002868	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
568819002869	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
568819002870	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
568819002871	active site
568819002872	dimer interface [polypeptide binding]; other site
568819002873	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
568819002874	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
568819002875	active site
568819002876	trimer interface [polypeptide binding]; other site
568819002877	allosteric site; other site
568819002878	active site lid [active]
568819002879	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819002880	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819002881	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819002882	DNA-binding site [nucleotide binding]; DNA binding site
568819002883	UTRA domain; Region: UTRA; pfam07702
568819002884	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
568819002885	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
568819002886	Mg++ binding site [ion binding]; other site
568819002887	putative catalytic motif [active]
568819002888	substrate binding site [chemical binding]; other site
568819002889	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
568819002890	Peptidase family U32; Region: Peptidase_U32; pfam01136
568819002891	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
568819002892	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
568819002893	Peptidase family U32; Region: Peptidase_U32; pfam01136
568819002894	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
568819002895	heat shock protein HtpX; Provisional; Region: PRK04897
568819002896	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
568819002897	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
568819002898	catalytic residues [active]
568819002899	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
568819002900	putative active site [active]
568819002901	putative metal binding residues [ion binding]; other site
568819002902	signature motif; other site
568819002903	putative triphosphate binding site [ion binding]; other site
568819002904	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819002905	TPR motif; other site
568819002906	binding surface
568819002907	Tetratrico peptide repeat; Region: TPR_5; pfam12688
568819002908	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819002909	synthetase active site [active]
568819002910	NTP binding site [chemical binding]; other site
568819002911	metal binding site [ion binding]; metal-binding site
568819002912	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
568819002913	ATP-NAD kinase; Region: NAD_kinase; pfam01513
568819002914	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568819002915	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568819002916	active site
568819002917	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
568819002918	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
568819002919	NAD binding site [chemical binding]; other site
568819002920	homotetramer interface [polypeptide binding]; other site
568819002921	homodimer interface [polypeptide binding]; other site
568819002922	substrate binding site [chemical binding]; other site
568819002923	active site
568819002924	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
568819002925	DltD N-terminal region; Region: DltD_N; pfam04915
568819002926	DltD central region; Region: DltD_M; pfam04918
568819002927	DltD C-terminal region; Region: DltD_C; pfam04914
568819002928	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
568819002929	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
568819002930	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
568819002931	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
568819002932	acyl-activating enzyme (AAE) consensus motif; other site
568819002933	AMP binding site [chemical binding]; other site
568819002934	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
568819002935	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819002936	active site
568819002937	dimer interface [polypeptide binding]; other site
568819002938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819002939	Coenzyme A binding pocket [chemical binding]; other site
568819002940	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
568819002941	Putative esterase; Region: Esterase; pfam00756
568819002942	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
568819002943	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
568819002944	homodimer interface [polypeptide binding]; other site
568819002945	substrate-cofactor binding pocket; other site
568819002946	catalytic residue [active]
568819002947	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568819002948	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819002949	Walker A/P-loop; other site
568819002950	ATP binding site [chemical binding]; other site
568819002951	Q-loop/lid; other site
568819002952	ABC transporter signature motif; other site
568819002953	Walker B; other site
568819002954	D-loop; other site
568819002955	H-loop/switch region; other site
568819002956	ABC-2 type transporter; Region: ABC2_membrane; cl17235
568819002957	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
568819002958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819002959	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819002960	putative substrate translocation pore; other site
568819002961	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819002962	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
568819002963	putative oligomer interface [polypeptide binding]; other site
568819002964	putative active site [active]
568819002965	metal binding site [ion binding]; metal-binding site
568819002966	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
568819002967	catalytic residues [active]
568819002968	dimer interface [polypeptide binding]; other site
568819002969	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
568819002970	LytTr DNA-binding domain; Region: LytTR; pfam04397
568819002971	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819002972	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819002973	Walker A/P-loop; other site
568819002974	ATP binding site [chemical binding]; other site
568819002975	Q-loop/lid; other site
568819002976	ABC transporter signature motif; other site
568819002977	Walker B; other site
568819002978	D-loop; other site
568819002979	H-loop/switch region; other site
568819002980	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
568819002981	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
568819002982	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568819002983	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
568819002984	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
568819002985	G1 box; other site
568819002986	putative GEF interaction site [polypeptide binding]; other site
568819002987	GTP/Mg2+ binding site [chemical binding]; other site
568819002988	Switch I region; other site
568819002989	G2 box; other site
568819002990	G3 box; other site
568819002991	Switch II region; other site
568819002992	G4 box; other site
568819002993	G5 box; other site
568819002994	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
568819002995	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819002996	MarR family; Region: MarR_2; cl17246
568819002997	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819002998	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
568819002999	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
568819003000	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
568819003001	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
568819003002	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
568819003003	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
568819003004	Acyltransferase family; Region: Acyl_transf_3; pfam01757
568819003005	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
568819003006	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819003007	DNA binding site [nucleotide binding]
568819003008	active site
568819003009	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
568819003010	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819003011	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
568819003012	Walker A motif; other site
568819003013	ATP binding site [chemical binding]; other site
568819003014	Walker B motif; other site
568819003015	arginine finger; other site
568819003016	UvrB/uvrC motif; Region: UVR; pfam02151
568819003017	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819003018	Walker A motif; other site
568819003019	ATP binding site [chemical binding]; other site
568819003020	Walker B motif; other site
568819003021	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
568819003022	CAAX protease self-immunity; Region: Abi; pfam02517
568819003023	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
568819003024	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568819003025	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
568819003026	nucleotide binding site [chemical binding]; other site
568819003027	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
568819003028	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
568819003029	dimerization domain swap beta strand [polypeptide binding]; other site
568819003030	regulatory protein interface [polypeptide binding]; other site
568819003031	active site
568819003032	regulatory phosphorylation site [posttranslational modification]; other site
568819003033	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
568819003034	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
568819003035	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
568819003036	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
568819003037	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568819003038	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568819003039	putative active site [active]
568819003040	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
568819003041	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568819003042	aminotransferase A; Validated; Region: PRK07683
568819003043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819003044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819003045	homodimer interface [polypeptide binding]; other site
568819003046	catalytic residue [active]
568819003047	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
568819003048	FOG: CBS domain [General function prediction only]; Region: COG0517
568819003049	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
568819003050	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819003051	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819003052	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819003053	dimerization interface [polypeptide binding]; other site
568819003054	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
568819003055	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
568819003056	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819003057	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819003058	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819003059	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
568819003060	metal binding site [ion binding]; metal-binding site
568819003061	putative dimer interface [polypeptide binding]; other site
568819003062	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
568819003063	Mechanosensitive ion channel; Region: MS_channel; pfam00924
568819003064	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
568819003065	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003066	Walker A/P-loop; other site
568819003067	ATP binding site [chemical binding]; other site
568819003068	Q-loop/lid; other site
568819003069	ABC transporter signature motif; other site
568819003070	Walker B; other site
568819003071	D-loop; other site
568819003072	H-loop/switch region; other site
568819003073	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
568819003074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819003075	dimer interface [polypeptide binding]; other site
568819003076	conserved gate region; other site
568819003077	putative PBP binding loops; other site
568819003078	ABC-ATPase subunit interface; other site
568819003079	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
568819003080	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568819003081	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568819003082	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
568819003083	HPr interaction site; other site
568819003084	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819003085	active site
568819003086	phosphorylation site [posttranslational modification]
568819003087	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
568819003088	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
568819003089	S1 domain; Region: S1_2; pfam13509
568819003090	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
568819003091	RNA binding site [nucleotide binding]; other site
568819003092	Predicted membrane protein [Function unknown]; Region: COG4758
568819003093	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
568819003094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
568819003095	Histidine kinase; Region: HisKA_3; pfam07730
568819003096	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819003097	ATP binding site [chemical binding]; other site
568819003098	Mg2+ binding site [ion binding]; other site
568819003099	G-X-G motif; other site
568819003100	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568819003101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819003102	active site
568819003103	phosphorylation site [posttranslational modification]
568819003104	intermolecular recognition site; other site
568819003105	dimerization interface [polypeptide binding]; other site
568819003106	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568819003107	DNA binding residues [nucleotide binding]
568819003108	dimerization interface [polypeptide binding]; other site
568819003109	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
568819003110	TrkA-N domain; Region: TrkA_N; pfam02254
568819003111	TrkA-C domain; Region: TrkA_C; pfam02080
568819003112	Predicted membrane protein [Function unknown]; Region: COG1289
568819003113	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
568819003114	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
568819003115	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568819003116	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
568819003117	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568819003118	hypothetical protein; Provisional; Region: PRK13667
568819003119	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819003120	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819003121	active site
568819003122	motif I; other site
568819003123	motif II; other site
568819003124	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819003125	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819003126	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819003127	DNA binding site [nucleotide binding]
568819003128	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819003129	ligand binding site [chemical binding]; other site
568819003130	dimerization interface [polypeptide binding]; other site
568819003131	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
568819003132	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819003133	trimer interface [polypeptide binding]; other site
568819003134	substrate binding site [chemical binding]; other site
568819003135	Mn binding site [ion binding]; other site
568819003136	transketolase; Reviewed; Region: PRK05899
568819003137	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819003138	TPP-binding site [chemical binding]; other site
568819003139	dimer interface [polypeptide binding]; other site
568819003140	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
568819003141	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819003142	PYR/PP interface [polypeptide binding]; other site
568819003143	dimer interface [polypeptide binding]; other site
568819003144	TPP binding site [chemical binding]; other site
568819003145	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819003146	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
568819003147	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
568819003148	nucleotide binding site [chemical binding]; other site
568819003149	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
568819003150	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568819003151	active site turn [active]
568819003152	phosphorylation site [posttranslational modification]
568819003153	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568819003154	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
568819003155	HPr interaction site; other site
568819003156	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819003157	active site
568819003158	phosphorylation site [posttranslational modification]
568819003159	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
568819003160	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
568819003161	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
568819003162	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
568819003163	GTP binding site; other site
568819003164	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
568819003165	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819003166	Walker A/P-loop; other site
568819003167	ATP binding site [chemical binding]; other site
568819003168	Q-loop/lid; other site
568819003169	ABC transporter signature motif; other site
568819003170	Walker B; other site
568819003171	D-loop; other site
568819003172	H-loop/switch region; other site
568819003173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819003174	dimer interface [polypeptide binding]; other site
568819003175	conserved gate region; other site
568819003176	putative PBP binding loops; other site
568819003177	ABC-ATPase subunit interface; other site
568819003178	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
568819003179	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
568819003180	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
568819003181	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
568819003182	dimer interface [polypeptide binding]; other site
568819003183	putative functional site; other site
568819003184	putative MPT binding site; other site
568819003185	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
568819003186	Walker A motif; other site
568819003187	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
568819003188	MoaE homodimer interface [polypeptide binding]; other site
568819003189	MoaD interaction [polypeptide binding]; other site
568819003190	active site residues [active]
568819003191	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
568819003192	MoaE interaction surface [polypeptide binding]; other site
568819003193	MoeB interaction surface [polypeptide binding]; other site
568819003194	thiocarboxylated glycine; other site
568819003195	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
568819003196	trimer interface [polypeptide binding]; other site
568819003197	dimer interface [polypeptide binding]; other site
568819003198	putative active site [active]
568819003199	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
568819003200	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568819003201	FeS/SAM binding site; other site
568819003202	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
568819003203	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
568819003204	MPT binding site; other site
568819003205	trimer interface [polypeptide binding]; other site
568819003206	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
568819003207	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
568819003208	ATP binding site [chemical binding]; other site
568819003209	substrate interface [chemical binding]; other site
568819003210	Flavin Reductases; Region: FlaRed; cl00801
568819003211	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
568819003212	active site
568819003213	catalytic residues [active]
568819003214	metal binding site [ion binding]; metal-binding site
568819003215	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
568819003216	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568819003217	TPP-binding site [chemical binding]; other site
568819003218	tetramer interface [polypeptide binding]; other site
568819003219	heterodimer interface [polypeptide binding]; other site
568819003220	phosphorylation loop region [posttranslational modification]
568819003221	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568819003222	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568819003223	alpha subunit interface [polypeptide binding]; other site
568819003224	TPP binding site [chemical binding]; other site
568819003225	heterodimer interface [polypeptide binding]; other site
568819003226	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819003227	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
568819003228	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819003229	E3 interaction surface; other site
568819003230	lipoyl attachment site [posttranslational modification]; other site
568819003231	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819003232	E3 interaction surface; other site
568819003233	lipoyl attachment site [posttranslational modification]; other site
568819003234	e3 binding domain; Region: E3_binding; pfam02817
568819003235	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568819003236	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
568819003237	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568819003238	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819003239	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819003240	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
568819003241	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
568819003242	NAD(P) binding site [chemical binding]; other site
568819003243	LDH/MDH dimer interface [polypeptide binding]; other site
568819003244	substrate binding site [chemical binding]; other site
568819003245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476
568819003246	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
568819003247	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
568819003248	catalytic residues [active]
568819003249	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
568819003250	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
568819003251	Cl binding site [ion binding]; other site
568819003252	oligomer interface [polypeptide binding]; other site
568819003253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
568819003254	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
568819003255	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
568819003256	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
568819003257	active site
568819003258	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
568819003259	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
568819003260	G1 box; other site
568819003261	putative GEF interaction site [polypeptide binding]; other site
568819003262	GTP/Mg2+ binding site [chemical binding]; other site
568819003263	Switch I region; other site
568819003264	G2 box; other site
568819003265	G3 box; other site
568819003266	Switch II region; other site
568819003267	G4 box; other site
568819003268	G5 box; other site
568819003269	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
568819003270	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
568819003271	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
568819003272	hypothetical protein; Provisional; Region: PRK13666
568819003273	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
568819003274	pyruvate carboxylase; Reviewed; Region: PRK12999
568819003275	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819003276	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
568819003277	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
568819003278	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
568819003279	active site
568819003280	catalytic residues [active]
568819003281	metal binding site [ion binding]; metal-binding site
568819003282	homodimer binding site [polypeptide binding]; other site
568819003283	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
568819003284	carboxyltransferase (CT) interaction site; other site
568819003285	biotinylation site [posttranslational modification]; other site
568819003286	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
568819003287	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819003288	putative binding site residues; other site
568819003289	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
568819003290	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
568819003291	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
568819003292	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
568819003293	Walker A/P-loop; other site
568819003294	ATP binding site [chemical binding]; other site
568819003295	Q-loop/lid; other site
568819003296	ABC transporter signature motif; other site
568819003297	Walker B; other site
568819003298	D-loop; other site
568819003299	H-loop/switch region; other site
568819003300	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819003301	SH3-like domain; Region: SH3_8; pfam13457
568819003302	SH3-like domain; Region: SH3_8; pfam13457
568819003303	SH3-like domain; Region: SH3_8; pfam13457
568819003304	SH3-like domain; Region: SH3_8; pfam13457
568819003305	SH3-like domain; Region: SH3_8; pfam13457
568819003306	SH3-like domain; Region: SH3_8; pfam13457
568819003307	SH3-like domain; Region: SH3_8; pfam13457
568819003308	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
568819003309	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
568819003310	Ligand binding site; other site
568819003311	Putative Catalytic site; other site
568819003312	DXD motif; other site
568819003313	conserved hypothetical integral membrane protein; Region: TIGR03766
568819003314	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
568819003315	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568819003316	active site
568819003317	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819003318	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
568819003319	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
568819003320	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
568819003321	active site
568819003322	tetramer interface; other site
568819003323	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
568819003324	substrate binding site; other site
568819003325	dimer interface; other site
568819003326	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
568819003327	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819003328	putative NAD(P) binding site [chemical binding]; other site
568819003329	putative catalytic Zn binding site [ion binding]; other site
568819003330	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
568819003331	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
568819003332	active site
568819003333	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819003334	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
568819003335	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
568819003336	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
568819003337	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
568819003338	active site
568819003339	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
568819003340	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
568819003341	active site
568819003342	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
568819003343	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
568819003344	homodimer interface [polypeptide binding]; other site
568819003345	NAD binding pocket [chemical binding]; other site
568819003346	ATP binding pocket [chemical binding]; other site
568819003347	Mg binding site [ion binding]; other site
568819003348	active-site loop [active]
568819003349	Uncharacterized conserved protein [Function unknown]; Region: COG1359
568819003350	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
568819003351	active site
568819003352	P-loop; other site
568819003353	phosphorylation site [posttranslational modification]
568819003354	GMP synthase; Reviewed; Region: guaA; PRK00074
568819003355	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
568819003356	AMP/PPi binding site [chemical binding]; other site
568819003357	candidate oxyanion hole; other site
568819003358	catalytic triad [active]
568819003359	potential glutamine specificity residues [chemical binding]; other site
568819003360	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
568819003361	ATP Binding subdomain [chemical binding]; other site
568819003362	Dimerization subdomain; other site
568819003363	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819003364	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819003365	active site
568819003366	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819003367	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003368	Walker A/P-loop; other site
568819003369	ATP binding site [chemical binding]; other site
568819003370	Q-loop/lid; other site
568819003371	ABC transporter signature motif; other site
568819003372	Walker B; other site
568819003373	D-loop; other site
568819003374	H-loop/switch region; other site
568819003375	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
568819003376	putative FMN binding site [chemical binding]; other site
568819003377	NADPH bind site [chemical binding]; other site
568819003378	thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603
568819003379	YcaO-like family; Region: YcaO; pfam02624
568819003380	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
568819003381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003382	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003383	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003384	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819003385	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819003386	active site
568819003387	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
568819003388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003389	Walker A/P-loop; other site
568819003390	ATP binding site [chemical binding]; other site
568819003391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003392	Q-loop/lid; other site
568819003393	ABC transporter signature motif; other site
568819003394	Walker B; other site
568819003395	D-loop; other site
568819003396	H-loop/switch region; other site
568819003398	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568819003399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568819003400	Coenzyme A binding pocket [chemical binding]; other site
568819003401	MepB protein; Region: MepB; cl01985
568819003402	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568819003403	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819003404	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819003405	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819003406	Coenzyme A binding pocket [chemical binding]; other site
568819003407	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819003408	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
568819003409	DNA binding residues [nucleotide binding]
568819003410	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
568819003411	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819003412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003413	Walker A/P-loop; other site
568819003414	ATP binding site [chemical binding]; other site
568819003415	Q-loop/lid; other site
568819003416	ABC transporter signature motif; other site
568819003417	Walker B; other site
568819003418	D-loop; other site
568819003419	H-loop/switch region; other site
568819003420	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819003421	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819003422	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003423	Walker A/P-loop; other site
568819003424	ATP binding site [chemical binding]; other site
568819003425	Q-loop/lid; other site
568819003426	ABC transporter signature motif; other site
568819003427	Walker B; other site
568819003428	D-loop; other site
568819003429	H-loop/switch region; other site
568819003430	Uncharacterized conserved protein [Function unknown]; Region: COG1359
568819003431	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819003432	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819003433	DNA binding residues [nucleotide binding]
568819003434	putative dimer interface [polypeptide binding]; other site
568819003436	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568819003437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568819003438	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
568819003439	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819003440	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819003441	LRR adjacent; Region: LRR_adjacent; pfam08191
568819003442	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819003443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
568819003444	Clp protease; Region: CLP_protease; pfam00574
568819003445	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568819003446	oligomer interface [polypeptide binding]; other site
568819003447	active site residues [active]
568819003448	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819003449	dimer interface [polypeptide binding]; other site
568819003450	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819003451	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
568819003452	Putative NAD(P)-binding; Region: NAD_binding_7; cl17660
568819003453	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
568819003454	SLBB domain; Region: SLBB; pfam10531
568819003455	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
568819003456	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
568819003457	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003458	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
568819003459	putative hexamer interface [polypeptide binding]; other site
568819003460	putative hexagonal pore; other site
568819003461	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
568819003462	putative hexamer interface [polypeptide binding]; other site
568819003463	putative hexagonal pore; other site
568819003464	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
568819003465	putative hexamer interface [polypeptide binding]; other site
568819003466	putative hexagonal pore; other site
568819003467	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
568819003468	G1 box; other site
568819003469	GTP/Mg2+ binding site [chemical binding]; other site
568819003470	G2 box; other site
568819003471	Switch I region; other site
568819003472	G3 box; other site
568819003473	Switch II region; other site
568819003474	G4 box; other site
568819003475	G5 box; other site
568819003476	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
568819003477	homotrimer interface [polypeptide binding]; other site
568819003478	Walker A motif; other site
568819003479	GTP binding site [chemical binding]; other site
568819003480	Walker B motif; other site
568819003481	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
568819003482	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819003483	catalytic core [active]
568819003484	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
568819003485	Sensory domain found in PocR; Region: PocR; pfam10114
568819003486	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003487	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003488	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003489	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003490	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003491	Hexamer interface [polypeptide binding]; other site
568819003492	Hexagonal pore residue; other site
568819003493	propanediol utilization protein PduB; Provisional; Region: PRK15415
568819003494	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
568819003495	putative hexamer interface [polypeptide binding]; other site
568819003496	putative hexagonal pore; other site
568819003497	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
568819003498	putative hexamer interface [polypeptide binding]; other site
568819003499	putative hexagonal pore; other site
568819003500	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
568819003501	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
568819003502	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
568819003503	alpha-beta subunit interface [polypeptide binding]; other site
568819003504	alpha-gamma subunit interface [polypeptide binding]; other site
568819003505	active site
568819003506	substrate and K+ binding site; other site
568819003507	K+ binding site [ion binding]; other site
568819003508	cobalamin binding site [chemical binding]; other site
568819003509	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
568819003510	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
568819003511	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
568819003512	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
568819003513	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003514	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
568819003515	putative hexamer interface [polypeptide binding]; other site
568819003516	putative hexagonal pore; other site
568819003517	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003518	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003519	Hexamer interface [polypeptide binding]; other site
568819003520	Hexagonal pore residue; other site
568819003521	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
568819003522	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003523	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003524	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
568819003525	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819003526	nucleotide binding site [chemical binding]; other site
568819003527	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
568819003528	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
568819003529	Hexamer/Pentamer interface [polypeptide binding]; other site
568819003530	central pore; other site
568819003531	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
568819003532	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
568819003533	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
568819003534	putative catalytic cysteine [active]
568819003535	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
568819003536	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
568819003537	putative active site [active]
568819003538	metal binding site [ion binding]; metal-binding site
568819003539	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
568819003540	amphipathic channel; other site
568819003541	Asn-Pro-Ala signature motifs; other site
568819003542	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
568819003543	propionate/acetate kinase; Provisional; Region: PRK12379
568819003544	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
568819003545	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819003546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819003547	homodimer interface [polypeptide binding]; other site
568819003548	catalytic residue [active]
568819003549	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
568819003550	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
568819003551	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
568819003552	putative active site [active]
568819003553	metal binding site [ion binding]; metal-binding site
568819003554	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
568819003555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819003556	active site
568819003557	phosphorylation site [posttranslational modification]
568819003558	intermolecular recognition site; other site
568819003559	dimerization interface [polypeptide binding]; other site
568819003560	ANTAR domain; Region: ANTAR; pfam03861
568819003561	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
568819003562	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
568819003563	Histidine kinase; Region: HisKA_2; pfam07568
568819003564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819003565	ATP binding site [chemical binding]; other site
568819003566	Mg2+ binding site [ion binding]; other site
568819003567	G-X-G motif; other site
568819003568	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
568819003569	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
568819003570	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
568819003571	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
568819003572	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
568819003573	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
568819003574	putative hexamer interface [polypeptide binding]; other site
568819003575	putative hexagonal pore; other site
568819003576	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
568819003577	putative hexamer interface [polypeptide binding]; other site
568819003578	putative hexagonal pore; other site
568819003579	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003580	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
568819003581	Hexamer interface [polypeptide binding]; other site
568819003582	Hexagonal pore residue; other site
568819003583	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
568819003584	putative catalytic cysteine [active]
568819003585	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
568819003586	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
568819003587	Hexamer interface [polypeptide binding]; other site
568819003588	Putative hexagonal pore residue; other site
568819003589	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
568819003590	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
568819003591	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003592	Propanediol utilisation protein PduL; Region: PduL; pfam06130
568819003593	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
568819003594	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
568819003595	Hexamer/Pentamer interface [polypeptide binding]; other site
568819003596	central pore; other site
568819003597	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
568819003598	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
568819003599	putative hexamer interface [polypeptide binding]; other site
568819003600	putative hexagonal pore; other site
568819003601	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
568819003602	putative hexamer interface [polypeptide binding]; other site
568819003603	putative hexagonal pore; other site
568819003604	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
568819003605	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
568819003606	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
568819003607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003608	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819003609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819003610	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
568819003611	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
568819003612	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
568819003613	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
568819003614	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
568819003615	catalytic triad [active]
568819003616	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
568819003617	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
568819003618	Precorrin-8X methylmutase; Region: CbiC; pfam02570
568819003619	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
568819003620	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
568819003621	active site
568819003622	putative homodimer interface [polypeptide binding]; other site
568819003623	SAM binding site [chemical binding]; other site
568819003624	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
568819003625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819003626	S-adenosylmethionine binding site [chemical binding]; other site
568819003627	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
568819003628	active site
568819003629	SAM binding site [chemical binding]; other site
568819003630	homodimer interface [polypeptide binding]; other site
568819003631	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
568819003632	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
568819003633	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
568819003634	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
568819003635	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
568819003636	active site
568819003637	SAM binding site [chemical binding]; other site
568819003638	homodimer interface [polypeptide binding]; other site
568819003639	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
568819003640	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
568819003641	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
568819003642	active site
568819003643	SAM binding site [chemical binding]; other site
568819003644	homodimer interface [polypeptide binding]; other site
568819003645	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
568819003646	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
568819003647	active site
568819003648	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
568819003649	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
568819003650	active site
568819003651	C-terminal domain interface [polypeptide binding]; other site
568819003652	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
568819003653	active site
568819003654	N-terminal domain interface [polypeptide binding]; other site
568819003655	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
568819003656	active site
568819003657	SAM binding site [chemical binding]; other site
568819003658	homodimer interface [polypeptide binding]; other site
568819003659	cobalt transport protein CbiM; Validated; Region: PRK08319
568819003660	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
568819003661	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
568819003662	cobalt transport protein CbiQ; Provisional; Region: PRK15485
568819003663	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
568819003664	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568819003665	Walker A/P-loop; other site
568819003666	ATP binding site [chemical binding]; other site
568819003667	Q-loop/lid; other site
568819003668	ABC transporter signature motif; other site
568819003669	Walker B; other site
568819003670	D-loop; other site
568819003671	H-loop/switch region; other site
568819003672	cobyric acid synthase; Provisional; Region: PRK00784
568819003673	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568819003674	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568819003675	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
568819003676	catalytic triad [active]
568819003677	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
568819003678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
568819003679	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
568819003680	AAA domain; Region: AAA_17; cl17253
568819003681	Predicted transcriptional regulators [Transcription]; Region: COG1695
568819003682	Transcriptional regulator PadR-like family; Region: PadR; cl17335
568819003683	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
568819003684	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819003685	SH3-like domain; Region: SH3_8; pfam13457
568819003686	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819003687	SH3-like domain; Region: SH3_8; pfam13457
568819003688	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819003689	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568819003690	oligomer interface [polypeptide binding]; other site
568819003691	active site
568819003692	metal binding site [ion binding]; metal-binding site
568819003693	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
568819003694	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
568819003695	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
568819003696	Predicted transcriptional regulators [Transcription]; Region: COG1733
568819003697	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
568819003698	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
568819003699	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
568819003700	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
568819003701	dimer interface [polypeptide binding]; other site
568819003702	motif 1; other site
568819003703	active site
568819003704	motif 2; other site
568819003705	motif 3; other site
568819003706	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
568819003707	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568819003708	putative tRNA-binding site [nucleotide binding]; other site
568819003709	B3/4 domain; Region: B3_4; pfam03483
568819003710	tRNA synthetase B5 domain; Region: B5; smart00874
568819003711	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
568819003712	dimer interface [polypeptide binding]; other site
568819003713	motif 1; other site
568819003714	motif 3; other site
568819003715	motif 2; other site
568819003716	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
568819003717	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819003718	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819003719	Walker A/P-loop; other site
568819003720	ATP binding site [chemical binding]; other site
568819003721	Q-loop/lid; other site
568819003722	ABC transporter signature motif; other site
568819003723	Walker B; other site
568819003724	D-loop; other site
568819003725	H-loop/switch region; other site
568819003726	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819003727	FtsX-like permease family; Region: FtsX; pfam02687
568819003728	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
568819003729	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819003730	FtsX-like permease family; Region: FtsX; pfam02687
568819003731	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819003732	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819003733	putative DNA binding site [nucleotide binding]; other site
568819003734	putative Zn2+ binding site [ion binding]; other site
568819003735	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
568819003736	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
568819003737	ligand binding site [chemical binding]; other site
568819003738	active site
568819003739	UGI interface [polypeptide binding]; other site
568819003740	catalytic site [active]
568819003741	ribonuclease HIII; Provisional; Region: PRK00996
568819003742	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
568819003743	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
568819003744	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819003745	active site
568819003746	Cell division protein ZapA; Region: ZapA; cl01146
568819003747	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
568819003748	Colicin V production protein; Region: Colicin_V; pfam02674
568819003749	hypothetical protein; Provisional; Region: PRK08609
568819003750	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
568819003751	active site
568819003752	primer binding site [nucleotide binding]; other site
568819003753	NTP  binding site [chemical binding]; other site
568819003754	metal binding triad [ion binding]; metal-binding site
568819003755	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
568819003756	active site
568819003757	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
568819003758	MutS domain III; Region: MutS_III; pfam05192
568819003759	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819003760	Walker A/P-loop; other site
568819003761	ATP binding site [chemical binding]; other site
568819003762	Q-loop/lid; other site
568819003763	ABC transporter signature motif; other site
568819003764	Walker B; other site
568819003765	D-loop; other site
568819003766	H-loop/switch region; other site
568819003767	Smr domain; Region: Smr; pfam01713
568819003768	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819003769	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568819003770	catalytic residues [active]
568819003771	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
568819003772	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
568819003773	GIY-YIG motif/motif A; other site
568819003774	active site
568819003775	catalytic site [active]
568819003776	putative DNA binding site [nucleotide binding]; other site
568819003777	metal binding site [ion binding]; metal-binding site
568819003778	UvrB/uvrC motif; Region: UVR; pfam02151
568819003779	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
568819003780	aspartate kinase; Reviewed; Region: PRK06635
568819003781	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
568819003782	putative nucleotide binding site [chemical binding]; other site
568819003783	putative catalytic residues [active]
568819003784	putative Mg ion binding site [ion binding]; other site
568819003785	putative aspartate binding site [chemical binding]; other site
568819003786	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
568819003787	putative allosteric regulatory site; other site
568819003788	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
568819003789	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
568819003790	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
568819003791	ribonuclease PH; Reviewed; Region: rph; PRK00173
568819003792	Ribonuclease PH; Region: RNase_PH_bact; cd11362
568819003793	hexamer interface [polypeptide binding]; other site
568819003794	active site
568819003795	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
568819003796	active site
568819003797	dimerization interface [polypeptide binding]; other site
568819003798	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
568819003799	active site
568819003800	metal binding site [ion binding]; metal-binding site
568819003801	homotetramer interface [polypeptide binding]; other site
568819003802	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819003803	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
568819003804	LRR adjacent; Region: LRR_adjacent; pfam08191
568819003805	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819003806	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819003807	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819003808	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819003809	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819003810	Uncharacterized conserved protein [Function unknown]; Region: COG5361
568819003811	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
568819003812	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
568819003813	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
568819003814	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
568819003815	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
568819003816	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819003817	dimer interface [polypeptide binding]; other site
568819003818	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819003819	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819003820	catalytic core [active]
568819003821	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
568819003822	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568819003823	ATP binding site [chemical binding]; other site
568819003824	Mg++ binding site [ion binding]; other site
568819003825	motif III; other site
568819003826	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819003827	nucleotide binding region [chemical binding]; other site
568819003828	ATP-binding site [chemical binding]; other site
568819003829	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
568819003830	RNA binding site [nucleotide binding]; other site
568819003831	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819003832	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
568819003833	putative active site [active]
568819003834	nucleotide binding site [chemical binding]; other site
568819003835	nudix motif; other site
568819003836	putative metal binding site [ion binding]; other site
568819003837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819003838	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819003839	putative substrate translocation pore; other site
568819003840	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819003841	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819003842	ligand binding site [chemical binding]; other site
568819003843	flexible hinge region; other site
568819003844	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819003845	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819003846	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819003847	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819003848	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
568819003849	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819003850	DNA-binding site [nucleotide binding]; DNA binding site
568819003851	UTRA domain; Region: UTRA; pfam07702
568819003852	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
568819003853	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
568819003854	Ca binding site [ion binding]; other site
568819003855	active site
568819003856	catalytic site [active]
568819003857	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568819003858	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
568819003859	active site turn [active]
568819003860	phosphorylation site [posttranslational modification]
568819003861	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568819003862	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
568819003863	nudix motif; other site
568819003864	Protein of unknown function (DUF877); Region: DUF877; cl05484
568819003865	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
568819003866	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819003867	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
568819003868	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
568819003869	putative catalytic cysteine [active]
568819003870	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
568819003871	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
568819003872	nucleotide binding site [chemical binding]; other site
568819003873	homotetrameric interface [polypeptide binding]; other site
568819003874	putative phosphate binding site [ion binding]; other site
568819003875	putative allosteric binding site; other site
568819003876	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
568819003877	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
568819003878	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568819003879	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819003880	non-specific DNA binding site [nucleotide binding]; other site
568819003881	salt bridge; other site
568819003882	sequence-specific DNA binding site [nucleotide binding]; other site
568819003883	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819003884	non-specific DNA binding site [nucleotide binding]; other site
568819003885	salt bridge; other site
568819003886	sequence-specific DNA binding site [nucleotide binding]; other site
568819003887	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
568819003888	active site
568819003889	trigger factor; Provisional; Region: tig; PRK01490
568819003890	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
568819003891	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
568819003892	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
568819003893	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
568819003894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819003895	Walker A motif; other site
568819003896	ATP binding site [chemical binding]; other site
568819003897	Walker B motif; other site
568819003898	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568819003899	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568819003900	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003901	Catalytic site [active]
568819003902	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003903	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
568819003904	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003905	Catalytic site [active]
568819003906	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
568819003907	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
568819003908	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003909	Catalytic site [active]
568819003910	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
568819003911	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
568819003912	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
568819003913	GTP/Mg2+ binding site [chemical binding]; other site
568819003914	G4 box; other site
568819003915	G5 box; other site
568819003916	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
568819003917	G1 box; other site
568819003918	G1 box; other site
568819003919	GTP/Mg2+ binding site [chemical binding]; other site
568819003920	Switch I region; other site
568819003921	G2 box; other site
568819003922	G2 box; other site
568819003923	G3 box; other site
568819003924	G3 box; other site
568819003925	Switch II region; other site
568819003926	Switch II region; other site
568819003927	G5 box; other site
568819003928	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
568819003929	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819003930	active site
568819003931	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
568819003932	DNA protecting protein DprA; Region: dprA; TIGR00732
568819003933	DNA topoisomerase I; Validated; Region: PRK05582
568819003934	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
568819003935	active site
568819003936	interdomain interaction site; other site
568819003937	putative metal-binding site [ion binding]; other site
568819003938	nucleotide binding site [chemical binding]; other site
568819003939	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568819003940	domain I; other site
568819003941	DNA binding groove [nucleotide binding]
568819003942	phosphate binding site [ion binding]; other site
568819003943	domain II; other site
568819003944	domain III; other site
568819003945	nucleotide binding site [chemical binding]; other site
568819003946	catalytic site [active]
568819003947	domain IV; other site
568819003948	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568819003949	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
568819003950	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
568819003951	Glucose inhibited division protein A; Region: GIDA; pfam01134
568819003952	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
568819003953	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
568819003954	active site
568819003955	DNA binding site [nucleotide binding]
568819003956	Int/Topo IB signature motif; other site
568819003957	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
568819003958	active site
568819003959	HslU subunit interaction site [polypeptide binding]; other site
568819003960	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
568819003961	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819003962	Walker A motif; other site
568819003963	ATP binding site [chemical binding]; other site
568819003964	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
568819003965	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
568819003966	transcriptional repressor CodY; Validated; Region: PRK04158
568819003967	CodY GAF-like domain; Region: CodY; pfam06018
568819003968	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
568819003969	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
568819003970	active site
568819003971	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
568819003972	active site
568819003973	catalytic residues [active]
568819003974	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
568819003975	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
568819003976	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
568819003977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819003978	Mg2+ binding site [ion binding]; other site
568819003979	G-X-G motif; other site
568819003980	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
568819003981	anchoring element; other site
568819003982	dimer interface [polypeptide binding]; other site
568819003983	ATP binding site [chemical binding]; other site
568819003984	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
568819003985	active site
568819003986	putative metal-binding site [ion binding]; other site
568819003987	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
568819003988	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
568819003989	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
568819003990	CAP-like domain; other site
568819003991	active site
568819003992	primary dimer interface [polypeptide binding]; other site
568819003993	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
568819003994	S-ribosylhomocysteinase; Provisional; Region: PRK02260
568819003995	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819003996	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
568819003997	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
568819003998	catalytic triad [active]
568819003999	catalytic triad [active]
568819004000	oxyanion hole [active]
568819004001	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
568819004002	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
568819004003	active site
568819004004	catalytic site [active]
568819004005	metal binding site [ion binding]; metal-binding site
568819004006	dimer interface [polypeptide binding]; other site
568819004007	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
568819004008	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
568819004009	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
568819004010	bacterial Hfq-like; Region: Hfq; cd01716
568819004011	hexamer interface [polypeptide binding]; other site
568819004012	Sm1 motif; other site
568819004013	RNA binding site [nucleotide binding]; other site
568819004014	Sm2 motif; other site
568819004015	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
568819004016	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
568819004017	HflX GTPase family; Region: HflX; cd01878
568819004018	G1 box; other site
568819004019	GTP/Mg2+ binding site [chemical binding]; other site
568819004020	Switch I region; other site
568819004021	G2 box; other site
568819004022	G3 box; other site
568819004023	Switch II region; other site
568819004024	G4 box; other site
568819004025	G5 box; other site
568819004026	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
568819004027	Aluminium resistance protein; Region: Alum_res; pfam06838
568819004028	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
568819004029	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568819004030	DNA binding residues [nucleotide binding]
568819004031	putative dimer interface [polypeptide binding]; other site
568819004032	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
568819004033	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
568819004034	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
568819004035	arsenical pump membrane protein; Provisional; Region: PRK15445
568819004036	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
568819004037	transmembrane helices; other site
568819004038	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568819004039	LexA repressor; Validated; Region: PRK00215
568819004040	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819004041	putative DNA binding site [nucleotide binding]; other site
568819004042	putative Zn2+ binding site [ion binding]; other site
568819004043	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
568819004044	Catalytic site [active]
568819004045	cell division suppressor protein YneA; Provisional; Region: PRK14125
568819004046	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
568819004047	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
568819004048	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819004049	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819004050	TPP-binding site [chemical binding]; other site
568819004051	dimer interface [polypeptide binding]; other site
568819004052	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819004053	PYR/PP interface [polypeptide binding]; other site
568819004054	dimer interface [polypeptide binding]; other site
568819004055	TPP binding site [chemical binding]; other site
568819004056	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819004057	hypothetical protein; Provisional; Region: PRK01844
568819004058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
568819004059	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568819004060	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819004061	S-adenosylmethionine binding site [chemical binding]; other site
568819004062	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
568819004063	ParB-like nuclease domain; Region: ParBc; pfam02195
568819004064	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
568819004065	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
568819004066	Active Sites [active]
568819004067	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
568819004068	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819004069	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
568819004070	putative nucleotide binding site [chemical binding]; other site
568819004071	uridine monophosphate binding site [chemical binding]; other site
568819004072	homohexameric interface [polypeptide binding]; other site
568819004073	ribosome recycling factor; Reviewed; Region: frr; PRK00083
568819004074	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
568819004075	hinge region; other site
568819004076	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
568819004077	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
568819004078	catalytic residue [active]
568819004079	putative FPP diphosphate  binding site; other site
568819004080	putative FPP binding hydrophobic cleft; other site
568819004081	dimer interface [polypeptide binding]; other site
568819004082	putative IPP diphosphate binding site; other site
568819004083	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
568819004084	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
568819004085	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
568819004086	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
568819004087	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
568819004088	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
568819004089	RIP metalloprotease RseP; Region: TIGR00054
568819004090	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568819004091	active site
568819004092	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
568819004093	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
568819004094	protein binding site [polypeptide binding]; other site
568819004095	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
568819004096	putative substrate binding region [chemical binding]; other site
568819004097	prolyl-tRNA synthetase; Provisional; Region: PRK09194
568819004098	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
568819004099	dimer interface [polypeptide binding]; other site
568819004100	motif 1; other site
568819004101	active site
568819004102	motif 2; other site
568819004103	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
568819004104	putative deacylase active site [active]
568819004105	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
568819004106	active site
568819004107	motif 3; other site
568819004108	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
568819004109	anticodon binding site; other site
568819004110	DNA polymerase III PolC; Validated; Region: polC; PRK00448
568819004111	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
568819004112	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
568819004113	generic binding surface II; other site
568819004114	generic binding surface I; other site
568819004115	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
568819004116	active site
568819004117	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568819004118	active site
568819004119	catalytic site [active]
568819004120	substrate binding site [chemical binding]; other site
568819004121	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
568819004122	ribosome maturation protein RimP; Reviewed; Region: PRK00092
568819004123	Sm and related proteins; Region: Sm_like; cl00259
568819004124	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
568819004125	putative oligomer interface [polypeptide binding]; other site
568819004126	putative RNA binding site [nucleotide binding]; other site
568819004127	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
568819004128	NusA N-terminal domain; Region: NusA_N; pfam08529
568819004129	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
568819004130	RNA binding site [nucleotide binding]; other site
568819004131	homodimer interface [polypeptide binding]; other site
568819004132	NusA-like KH domain; Region: KH_5; pfam13184
568819004133	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
568819004134	G-X-X-G motif; other site
568819004135	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
568819004136	putative RNA binding cleft [nucleotide binding]; other site
568819004137	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
568819004138	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568819004139	translation initiation factor IF-2; Region: IF-2; TIGR00487
568819004140	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
568819004141	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
568819004142	G1 box; other site
568819004143	putative GEF interaction site [polypeptide binding]; other site
568819004144	GTP/Mg2+ binding site [chemical binding]; other site
568819004145	Switch I region; other site
568819004146	G2 box; other site
568819004147	G3 box; other site
568819004148	Switch II region; other site
568819004149	G4 box; other site
568819004150	G5 box; other site
568819004151	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
568819004152	Translation-initiation factor 2; Region: IF-2; pfam11987
568819004153	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
568819004154	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
568819004155	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
568819004156	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
568819004157	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
568819004158	RNA binding site [nucleotide binding]; other site
568819004159	active site
568819004160	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
568819004161	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
568819004162	active site
568819004163	Riboflavin kinase; Region: Flavokinase; smart00904
568819004164	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
568819004165	16S/18S rRNA binding site [nucleotide binding]; other site
568819004166	S13e-L30e interaction site [polypeptide binding]; other site
568819004167	25S rRNA binding site [nucleotide binding]; other site
568819004168	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
568819004169	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
568819004170	RNase E interface [polypeptide binding]; other site
568819004171	trimer interface [polypeptide binding]; other site
568819004172	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
568819004173	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
568819004174	RNase E interface [polypeptide binding]; other site
568819004175	trimer interface [polypeptide binding]; other site
568819004176	active site
568819004177	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
568819004178	putative nucleic acid binding region [nucleotide binding]; other site
568819004179	G-X-X-G motif; other site
568819004180	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
568819004181	RNA binding site [nucleotide binding]; other site
568819004182	domain interface; other site
568819004183	GTPase RsgA; Reviewed; Region: PRK01889
568819004184	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
568819004185	RNA binding site [nucleotide binding]; other site
568819004186	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
568819004187	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568819004188	GTP/Mg2+ binding site [chemical binding]; other site
568819004189	G4 box; other site
568819004190	G5 box; other site
568819004191	G1 box; other site
568819004192	Switch I region; other site
568819004193	G2 box; other site
568819004194	G3 box; other site
568819004195	Switch II region; other site
568819004196	YceG-like family; Region: YceG; pfam02618
568819004197	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
568819004198	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
568819004199	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
568819004200	Rhomboid family; Region: Rhomboid; pfam01694
568819004201	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819004202	TPR motif; other site
568819004203	TPR repeat; Region: TPR_11; pfam13414
568819004204	binding surface
568819004205	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
568819004206	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
568819004207	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819004208	nucleotide binding site [chemical binding]; other site
568819004209	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
568819004210	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
568819004211	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
568819004212	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
568819004213	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
568819004214	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
568819004215	Type II/IV secretion system protein; Region: T2SE; pfam00437
568819004216	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568819004217	Walker A motif; other site
568819004218	ATP binding site [chemical binding]; other site
568819004219	Walker B motif; other site
568819004220	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
568819004221	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
568819004222	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
568819004223	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
568819004224	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
568819004225	tetramer interface [polypeptide binding]; other site
568819004226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004227	catalytic residue [active]
568819004228	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
568819004229	tetramer interface [polypeptide binding]; other site
568819004230	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819004231	catalytic residue [active]
568819004232	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
568819004233	active site residue [active]
568819004234	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
568819004235	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568819004236	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568819004237	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568819004238	active site
568819004239	elongation factor P; Validated; Region: PRK00529
568819004240	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
568819004241	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
568819004242	RNA binding site [nucleotide binding]; other site
568819004243	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
568819004244	RNA binding site [nucleotide binding]; other site
568819004245	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
568819004246	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
568819004247	carboxyltransferase (CT) interaction site; other site
568819004248	biotinylation site [posttranslational modification]; other site
568819004249	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
568819004250	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819004251	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568819004252	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
568819004253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
568819004254	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
568819004255	putative RNA binding site [nucleotide binding]; other site
568819004256	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
568819004257	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
568819004258	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
568819004259	homodimer interface [polypeptide binding]; other site
568819004260	NADP binding site [chemical binding]; other site
568819004261	substrate binding site [chemical binding]; other site
568819004262	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
568819004263	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
568819004264	generic binding surface II; other site
568819004265	generic binding surface I; other site
568819004266	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
568819004267	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568819004268	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819004269	substrate binding pocket [chemical binding]; other site
568819004270	chain length determination region; other site
568819004271	substrate-Mg2+ binding site; other site
568819004272	catalytic residues [active]
568819004273	aspartate-rich region 1; other site
568819004274	active site lid residues [active]
568819004275	aspartate-rich region 2; other site
568819004276	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568819004277	DNA-binding site [nucleotide binding]; DNA binding site
568819004278	RNA-binding motif; other site
568819004279	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
568819004280	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
568819004281	TPP-binding site; other site
568819004282	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819004283	PYR/PP interface [polypeptide binding]; other site
568819004284	dimer interface [polypeptide binding]; other site
568819004285	TPP binding site [chemical binding]; other site
568819004286	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819004287	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
568819004288	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819004289	RNA binding surface [nucleotide binding]; other site
568819004290	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
568819004291	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
568819004292	arginine repressor; Provisional; Region: PRK04280
568819004293	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
568819004294	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
568819004295	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
568819004296	Walker A/P-loop; other site
568819004297	ATP binding site [chemical binding]; other site
568819004298	Q-loop/lid; other site
568819004299	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
568819004300	ABC transporter signature motif; other site
568819004301	Walker B; other site
568819004302	D-loop; other site
568819004303	H-loop/switch region; other site
568819004304	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
568819004305	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819004306	nucleotide binding site [chemical binding]; other site
568819004307	Acetokinase family; Region: Acetate_kinase; cl17229
568819004308	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
568819004309	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819004310	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819004311	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
568819004312	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
568819004313	tetramer interface [polypeptide binding]; other site
568819004314	TPP-binding site [chemical binding]; other site
568819004315	heterodimer interface [polypeptide binding]; other site
568819004316	phosphorylation loop region [posttranslational modification]
568819004317	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
568819004318	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
568819004319	alpha subunit interface [polypeptide binding]; other site
568819004320	TPP binding site [chemical binding]; other site
568819004321	heterodimer interface [polypeptide binding]; other site
568819004322	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
568819004323	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
568819004324	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
568819004325	E3 interaction surface; other site
568819004326	lipoyl attachment site [posttranslational modification]; other site
568819004327	e3 binding domain; Region: E3_binding; pfam02817
568819004328	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
568819004329	peptidase T-like protein; Region: PepT-like; TIGR01883
568819004330	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
568819004331	metal binding site [ion binding]; metal-binding site
568819004332	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
568819004333	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
568819004334	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
568819004335	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819004336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819004337	active site
568819004338	phosphorylation site [posttranslational modification]
568819004339	intermolecular recognition site; other site
568819004340	dimerization interface [polypeptide binding]; other site
568819004341	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819004342	DNA binding site [nucleotide binding]
568819004343	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568819004344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819004345	dimerization interface [polypeptide binding]; other site
568819004346	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819004347	dimer interface [polypeptide binding]; other site
568819004348	phosphorylation site [posttranslational modification]
568819004349	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819004350	ATP binding site [chemical binding]; other site
568819004351	Mg2+ binding site [ion binding]; other site
568819004352	G-X-G motif; other site
568819004353	OxaA-like protein precursor; Validated; Region: PRK01622
568819004354	acylphosphatase; Provisional; Region: PRK14443
568819004355	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
568819004356	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
568819004357	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
568819004358	homotetramer interface [polypeptide binding]; other site
568819004359	FMN binding site [chemical binding]; other site
568819004360	homodimer contacts [polypeptide binding]; other site
568819004361	putative active site [active]
568819004362	putative substrate binding site [chemical binding]; other site
568819004363	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
568819004364	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
568819004365	active site residue [active]
568819004366	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
568819004367	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819004368	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819004369	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819004370	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
568819004371	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
568819004372	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568819004373	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
568819004374	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
568819004375	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
568819004376	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
568819004377	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
568819004378	ligand binding site [chemical binding]; other site
568819004379	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
568819004380	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
568819004381	Walker A/P-loop; other site
568819004382	ATP binding site [chemical binding]; other site
568819004383	Q-loop/lid; other site
568819004384	ABC transporter signature motif; other site
568819004385	Walker B; other site
568819004386	D-loop; other site
568819004387	H-loop/switch region; other site
568819004388	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
568819004389	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568819004390	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568819004391	TM-ABC transporter signature motif; other site
568819004392	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
568819004393	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
568819004394	TM-ABC transporter signature motif; other site
568819004395	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568819004396	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568819004397	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
568819004398	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
568819004399	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
568819004400	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
568819004401	classical (c) SDRs; Region: SDR_c; cd05233
568819004402	NAD(P) binding site [chemical binding]; other site
568819004403	active site
568819004404	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
568819004405	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819004406	non-specific DNA binding site [nucleotide binding]; other site
568819004407	salt bridge; other site
568819004408	sequence-specific DNA binding site [nucleotide binding]; other site
568819004409	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
568819004410	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
568819004411	competence damage-inducible protein A; Provisional; Region: PRK00549
568819004412	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
568819004413	putative MPT binding site; other site
568819004414	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
568819004415	recombinase A; Provisional; Region: recA; PRK09354
568819004416	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
568819004417	hexamer interface [polypeptide binding]; other site
568819004418	Walker A motif; other site
568819004419	ATP binding site [chemical binding]; other site
568819004420	Walker B motif; other site
568819004421	phosphodiesterase; Provisional; Region: PRK12704
568819004422	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819004423	Zn2+ binding site [ion binding]; other site
568819004424	Mg2+ binding site [ion binding]; other site
568819004425	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
568819004426	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819004427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568819004428	Coenzyme A binding pocket [chemical binding]; other site
568819004429	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
568819004430	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819004431	putative active site [active]
568819004432	metal binding site [ion binding]; metal-binding site
568819004433	homodimer binding site [polypeptide binding]; other site
568819004434	Predicted membrane protein [Function unknown]; Region: COG4550
568819004435	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
568819004436	MutS domain I; Region: MutS_I; pfam01624
568819004437	MutS domain II; Region: MutS_II; pfam05188
568819004438	MutS domain III; Region: MutS_III; pfam05192
568819004439	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
568819004440	Walker A/P-loop; other site
568819004441	ATP binding site [chemical binding]; other site
568819004442	Q-loop/lid; other site
568819004443	ABC transporter signature motif; other site
568819004444	Walker B; other site
568819004445	D-loop; other site
568819004446	H-loop/switch region; other site
568819004447	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
568819004448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819004449	ATP binding site [chemical binding]; other site
568819004450	Mg2+ binding site [ion binding]; other site
568819004451	G-X-G motif; other site
568819004452	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
568819004453	ATP binding site [chemical binding]; other site
568819004454	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
568819004455	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
568819004456	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
568819004457	Pyruvate formate lyase 1; Region: PFL1; cd01678
568819004458	coenzyme A binding site [chemical binding]; other site
568819004459	active site
568819004460	catalytic residues [active]
568819004461	glycine loop; other site
568819004462	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
568819004463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568819004464	FeS/SAM binding site; other site
568819004465	Predicted transcriptional regulators [Transcription]; Region: COG1695
568819004466	Transcriptional regulator PadR-like family; Region: PadR; cl17335
568819004467	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004468	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819004469	putative substrate translocation pore; other site
568819004470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819004471	non-specific DNA binding site [nucleotide binding]; other site
568819004472	salt bridge; other site
568819004473	sequence-specific DNA binding site [nucleotide binding]; other site
568819004474	topology modulation protein; Reviewed; Region: PRK08118
568819004475	AAA domain; Region: AAA_17; pfam13207
568819004476	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819004477	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819004478	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819004479	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819004480	putative acyltransferase; Provisional; Region: PRK05790
568819004481	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
568819004482	dimer interface [polypeptide binding]; other site
568819004483	active site
568819004484	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
568819004485	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
568819004486	dimer interface [polypeptide binding]; other site
568819004487	active site
568819004488	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
568819004489	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
568819004490	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819004491	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
568819004492	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
568819004493	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
568819004494	Domain of unknown function DUF20; Region: UPF0118; pfam01594
568819004495	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
568819004496	FAD binding domain; Region: FAD_binding_4; pfam01565
568819004497	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
568819004498	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
568819004499	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
568819004500	Walker A/P-loop; other site
568819004501	ATP binding site [chemical binding]; other site
568819004502	Q-loop/lid; other site
568819004503	ABC transporter signature motif; other site
568819004504	Walker B; other site
568819004505	D-loop; other site
568819004506	H-loop/switch region; other site
568819004507	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819004508	dimer interface [polypeptide binding]; other site
568819004509	conserved gate region; other site
568819004510	ABC-ATPase subunit interface; other site
568819004511	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
568819004512	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
568819004513	Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096
568819004514	manganese transport protein MntH; Reviewed; Region: PRK00701
568819004515	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
568819004516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819004517	dimer interface [polypeptide binding]; other site
568819004518	conserved gate region; other site
568819004519	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
568819004520	ABC-ATPase subunit interface; other site
568819004521	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
568819004522	LysR substrate binding domain; Region: LysR_substrate; pfam03466
568819004523	dimerization interface [polypeptide binding]; other site
568819004524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819004525	dimer interface [polypeptide binding]; other site
568819004526	conserved gate region; other site
568819004527	putative PBP binding loops; other site
568819004528	ABC-ATPase subunit interface; other site
568819004529	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
568819004530	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
568819004531	Walker A/P-loop; other site
568819004532	ATP binding site [chemical binding]; other site
568819004533	Q-loop/lid; other site
568819004534	ABC transporter signature motif; other site
568819004535	Walker B; other site
568819004536	D-loop; other site
568819004537	H-loop/switch region; other site
568819004538	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
568819004539	Predicted membrane protein [Function unknown]; Region: COG3859
568819004540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
568819004541	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
568819004542	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819004543	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819004544	ABC transporter; Region: ABC_tran_2; pfam12848
568819004545	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819004546	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
568819004547	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819004548	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819004549	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
568819004550	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
568819004551	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819004552	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
568819004553	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
568819004554	dihydrodipicolinate synthase; Region: dapA; TIGR00674
568819004555	dimer interface [polypeptide binding]; other site
568819004556	active site
568819004557	catalytic residue [active]
568819004558	aspartate kinase I; Reviewed; Region: PRK08210
568819004559	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
568819004560	nucleotide binding site [chemical binding]; other site
568819004561	substrate binding site [chemical binding]; other site
568819004562	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
568819004563	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
568819004564	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
568819004565	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
568819004566	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568819004567	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819004568	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568819004569	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
568819004570	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
568819004571	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
568819004572	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
568819004573	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
568819004574	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
568819004575	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
568819004576	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
568819004577	Predicted membrane protein [Function unknown]; Region: COG4392
568819004578	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
568819004579	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
568819004580	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819004581	metal binding site 2 [ion binding]; metal-binding site
568819004582	putative DNA binding helix; other site
568819004583	metal binding site 1 [ion binding]; metal-binding site
568819004584	dimer interface [polypeptide binding]; other site
568819004585	structural Zn2+ binding site [ion binding]; other site
568819004586	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
568819004587	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819004588	ABC-ATPase subunit  interface; other site
568819004589	dimer interface [polypeptide binding]; other site
568819004590	putative PBP binding regions; other site
568819004591	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
568819004592	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
568819004593	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
568819004594	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
568819004595	DHHA2 domain; Region: DHHA2; pfam02833
568819004596	endonuclease IV; Provisional; Region: PRK01060
568819004597	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
568819004598	AP (apurinic/apyrimidinic) site pocket; other site
568819004599	DNA interaction; other site
568819004600	Metal-binding active site; metal-binding site
568819004601	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
568819004602	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819004603	ATP binding site [chemical binding]; other site
568819004604	Mg++ binding site [ion binding]; other site
568819004605	motif III; other site
568819004606	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819004607	nucleotide binding region [chemical binding]; other site
568819004608	ATP-binding site [chemical binding]; other site
568819004609	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
568819004610	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
568819004611	Uncharacterized conserved protein [Function unknown]; Region: COG0327
568819004612	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
568819004613	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
568819004614	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
568819004615	Uncharacterized conserved protein [Function unknown]; Region: COG0327
568819004616	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
568819004617	Family of unknown function (DUF633); Region: DUF633; pfam04816
568819004618	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
568819004619	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
568819004620	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
568819004621	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
568819004622	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
568819004623	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
568819004624	DNA binding residues [nucleotide binding]
568819004625	DNA primase; Validated; Region: dnaG; PRK05667
568819004626	CHC2 zinc finger; Region: zf-CHC2; pfam01807
568819004627	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
568819004628	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
568819004629	active site
568819004630	metal binding site [ion binding]; metal-binding site
568819004631	interdomain interaction site; other site
568819004632	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
568819004633	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
568819004634	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
568819004635	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
568819004636	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
568819004637	DALR anticodon binding domain; Region: DALR_1; pfam05746
568819004638	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
568819004639	dimer interface [polypeptide binding]; other site
568819004640	motif 1; other site
568819004641	active site
568819004642	motif 2; other site
568819004643	motif 3; other site
568819004644	DNA repair protein RecO; Region: reco; TIGR00613
568819004645	Recombination protein O N terminal; Region: RecO_N; pfam11967
568819004646	Recombination protein O C terminal; Region: RecO_C; pfam02565
568819004647	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
568819004648	GTPase Era; Reviewed; Region: era; PRK00089
568819004649	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
568819004650	G1 box; other site
568819004651	GTP/Mg2+ binding site [chemical binding]; other site
568819004652	Switch I region; other site
568819004653	G2 box; other site
568819004654	Switch II region; other site
568819004655	G3 box; other site
568819004656	G4 box; other site
568819004657	G5 box; other site
568819004658	KH domain; Region: KH_2; pfam07650
568819004659	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
568819004660	active site
568819004661	catalytic motif [active]
568819004662	Zn binding site [ion binding]; other site
568819004663	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
568819004664	metal-binding heat shock protein; Provisional; Region: PRK00016
568819004665	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
568819004666	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
568819004667	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819004668	Zn2+ binding site [ion binding]; other site
568819004669	Mg2+ binding site [ion binding]; other site
568819004670	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
568819004671	PhoH-like protein; Region: PhoH; pfam02562
568819004672	Yqey-like protein; Region: YqeY; pfam09424
568819004673	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
568819004674	RNA methyltransferase, RsmE family; Region: TIGR00046
568819004675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
568819004676	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
568819004677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819004678	S-adenosylmethionine binding site [chemical binding]; other site
568819004679	chaperone protein DnaJ; Provisional; Region: PRK14280
568819004680	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
568819004681	HSP70 interaction site [polypeptide binding]; other site
568819004682	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
568819004683	substrate binding site [polypeptide binding]; other site
568819004684	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
568819004685	Zn binding sites [ion binding]; other site
568819004686	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
568819004687	dimer interface [polypeptide binding]; other site
568819004688	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
568819004689	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
568819004690	nucleotide binding site [chemical binding]; other site
568819004691	NEF interaction site [polypeptide binding]; other site
568819004692	SBD interface [polypeptide binding]; other site
568819004693	heat shock protein GrpE; Provisional; Region: PRK14140
568819004694	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
568819004695	dimer interface [polypeptide binding]; other site
568819004696	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
568819004697	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
568819004698	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
568819004699	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
568819004700	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568819004701	FeS/SAM binding site; other site
568819004702	HemN C-terminal domain; Region: HemN_C; pfam06969
568819004703	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568819004704	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
568819004705	NADP binding site [chemical binding]; other site
568819004706	putative substrate binding site [chemical binding]; other site
568819004707	active site
568819004708	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819004709	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819004710	DNA binding residues [nucleotide binding]
568819004711	putative dimer interface [polypeptide binding]; other site
568819004712	GTP-binding protein LepA; Provisional; Region: PRK05433
568819004713	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
568819004714	G1 box; other site
568819004715	putative GEF interaction site [polypeptide binding]; other site
568819004716	GTP/Mg2+ binding site [chemical binding]; other site
568819004717	Switch I region; other site
568819004718	G2 box; other site
568819004719	G3 box; other site
568819004720	Switch II region; other site
568819004721	G4 box; other site
568819004722	G5 box; other site
568819004723	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
568819004724	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
568819004725	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
568819004726	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
568819004727	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
568819004728	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
568819004729	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
568819004730	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
568819004731	Competence protein; Region: Competence; pfam03772
568819004732	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819004733	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
568819004734	catalytic motif [active]
568819004735	Zn binding site [ion binding]; other site
568819004736	SLBB domain; Region: SLBB; pfam10531
568819004737	comEA protein; Region: comE; TIGR01259
568819004738	Helix-hairpin-helix motif; Region: HHH; pfam00633
568819004739	Methyltransferase domain; Region: Methyltransf_23; pfam13489
568819004740	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819004741	S-adenosylmethionine binding site [chemical binding]; other site
568819004742	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
568819004743	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819004744	Zn2+ binding site [ion binding]; other site
568819004745	Mg2+ binding site [ion binding]; other site
568819004746	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
568819004747	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
568819004748	active site
568819004749	(T/H)XGH motif; other site
568819004750	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
568819004751	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
568819004752	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819004753	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819004754	shikimate binding site; other site
568819004755	NAD(P) binding site [chemical binding]; other site
568819004756	GTPase YqeH; Provisional; Region: PRK13796
568819004757	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
568819004758	GTP/Mg2+ binding site [chemical binding]; other site
568819004759	G4 box; other site
568819004760	G5 box; other site
568819004761	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
568819004762	G1 box; other site
568819004763	G1 box; other site
568819004764	GTP/Mg2+ binding site [chemical binding]; other site
568819004765	G2 box; other site
568819004766	Switch I region; other site
568819004767	G2 box; other site
568819004768	Switch I region; other site
568819004769	G3 box; other site
568819004770	G3 box; other site
568819004771	Switch II region; other site
568819004772	Switch II region; other site
568819004773	G4 box; other site
568819004774	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
568819004775	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819004776	motif II; other site
568819004777	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
568819004778	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
568819004779	active site
568819004780	Zn binding site [ion binding]; other site
568819004781	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
568819004782	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
568819004783	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
568819004784	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
568819004785	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
568819004786	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
568819004787	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
568819004788	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
568819004789	Sugar specificity; other site
568819004790	Pyrimidine base specificity; other site
568819004791	ATP-binding site [chemical binding]; other site
568819004792	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
568819004793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819004794	S-adenosylmethionine binding site [chemical binding]; other site
568819004795	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
568819004796	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
568819004797	dimerization interface [polypeptide binding]; other site
568819004798	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568819004799	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568819004800	hypothetical protein; Provisional; Region: PRK13678
568819004801	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
568819004802	hypothetical protein; Provisional; Region: PRK05473
568819004803	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
568819004804	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
568819004805	motif 1; other site
568819004806	active site
568819004807	motif 2; other site
568819004808	motif 3; other site
568819004809	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568819004810	DHHA1 domain; Region: DHHA1; pfam02272
568819004811	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819004812	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819004813	Walker A/P-loop; other site
568819004814	ATP binding site [chemical binding]; other site
568819004815	Q-loop/lid; other site
568819004816	ABC transporter signature motif; other site
568819004817	Walker B; other site
568819004818	D-loop; other site
568819004819	H-loop/switch region; other site
568819004820	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819004821	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819004822	FtsX-like permease family; Region: FtsX; pfam02687
568819004823	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819004824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819004825	active site
568819004826	phosphorylation site [posttranslational modification]
568819004827	intermolecular recognition site; other site
568819004828	dimerization interface [polypeptide binding]; other site
568819004829	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819004830	DNA binding site [nucleotide binding]
568819004831	sensor kinase CusS; Provisional; Region: PRK09835
568819004832	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819004833	dimerization interface [polypeptide binding]; other site
568819004834	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819004835	dimer interface [polypeptide binding]; other site
568819004836	phosphorylation site [posttranslational modification]
568819004837	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819004838	ATP binding site [chemical binding]; other site
568819004839	Mg2+ binding site [ion binding]; other site
568819004840	G-X-G motif; other site
568819004841	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
568819004842	AAA domain; Region: AAA_30; pfam13604
568819004843	Family description; Region: UvrD_C_2; pfam13538
568819004844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819004845	binding surface
568819004846	TPR motif; other site
568819004847	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
568819004848	TPR repeat; Region: TPR_11; pfam13414
568819004849	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819004850	binding surface
568819004851	TPR motif; other site
568819004852	TPR repeat; Region: TPR_11; pfam13414
568819004853	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
568819004854	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
568819004855	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
568819004856	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
568819004857	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568819004858	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819004859	catalytic residue [active]
568819004860	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
568819004861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819004862	Walker A motif; other site
568819004863	ATP binding site [chemical binding]; other site
568819004864	Walker B motif; other site
568819004865	arginine finger; other site
568819004866	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
568819004867	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819004868	Transcriptional regulator; Region: Rrf2; pfam02082
568819004869	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
568819004870	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
568819004871	Nitrogen regulatory protein P-II; Region: P-II; smart00938
568819004872	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
568819004873	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
568819004874	dimer interface [polypeptide binding]; other site
568819004875	anticodon binding site; other site
568819004876	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
568819004877	homodimer interface [polypeptide binding]; other site
568819004878	motif 1; other site
568819004879	active site
568819004880	motif 2; other site
568819004881	GAD domain; Region: GAD; pfam02938
568819004882	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
568819004883	motif 3; other site
568819004884	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
568819004885	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
568819004886	dimer interface [polypeptide binding]; other site
568819004887	motif 1; other site
568819004888	active site
568819004889	motif 2; other site
568819004890	motif 3; other site
568819004891	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
568819004892	anticodon binding site; other site
568819004893	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
568819004894	Bacterial SH3 domain; Region: SH3_3; pfam08239
568819004895	Bacterial SH3 domain; Region: SH3_3; pfam08239
568819004896	Bacterial SH3 domain homologues; Region: SH3b; smart00287
568819004897	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
568819004898	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
568819004899	active site
568819004900	metal binding site [ion binding]; metal-binding site
568819004901	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
568819004902	putative active site [active]
568819004903	dimerization interface [polypeptide binding]; other site
568819004904	putative tRNAtyr binding site [nucleotide binding]; other site
568819004905	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
568819004906	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819004907	Zn2+ binding site [ion binding]; other site
568819004908	Mg2+ binding site [ion binding]; other site
568819004909	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
568819004910	synthetase active site [active]
568819004911	NTP binding site [chemical binding]; other site
568819004912	metal binding site [ion binding]; metal-binding site
568819004913	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
568819004914	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
568819004915	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819004916	active site
568819004917	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
568819004918	DHH family; Region: DHH; pfam01368
568819004919	DHHA1 domain; Region: DHHA1; pfam02272
568819004920	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
568819004921	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
568819004922	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
568819004923	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
568819004924	Protein export membrane protein; Region: SecD_SecF; cl14618
568819004925	Protein export membrane protein; Region: SecD_SecF; pfam02355
568819004926	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
568819004927	Preprotein translocase subunit; Region: YajC; pfam02699
568819004928	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
568819004929	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
568819004930	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
568819004931	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
568819004932	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
568819004933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819004934	Walker A motif; other site
568819004935	ATP binding site [chemical binding]; other site
568819004936	Walker B motif; other site
568819004937	arginine finger; other site
568819004938	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
568819004939	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
568819004940	RuvA N terminal domain; Region: RuvA_N; pfam01330
568819004941	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
568819004942	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819004943	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819004944	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
568819004945	NAD binding site [chemical binding]; other site
568819004946	dimer interface [polypeptide binding]; other site
568819004947	substrate binding site [chemical binding]; other site
568819004948	hypothetical protein; Validated; Region: PRK00110
568819004949	prephenate dehydratase; Provisional; Region: PRK11898
568819004950	Prephenate dehydratase; Region: PDT; pfam00800
568819004951	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
568819004952	putative L-Phe binding site [chemical binding]; other site
568819004953	GTPase CgtA; Reviewed; Region: obgE; PRK12297
568819004954	GTP1/OBG; Region: GTP1_OBG; pfam01018
568819004955	Obg GTPase; Region: Obg; cd01898
568819004956	G1 box; other site
568819004957	GTP/Mg2+ binding site [chemical binding]; other site
568819004958	Switch I region; other site
568819004959	G2 box; other site
568819004960	G3 box; other site
568819004961	Switch II region; other site
568819004962	G4 box; other site
568819004963	G5 box; other site
568819004964	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
568819004965	glycerol kinase; Provisional; Region: glpK; PRK00047
568819004966	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
568819004967	N- and C-terminal domain interface [polypeptide binding]; other site
568819004968	active site
568819004969	MgATP binding site [chemical binding]; other site
568819004970	catalytic site [active]
568819004971	metal binding site [ion binding]; metal-binding site
568819004972	glycerol binding site [chemical binding]; other site
568819004973	homotetramer interface [polypeptide binding]; other site
568819004974	homodimer interface [polypeptide binding]; other site
568819004975	FBP binding site [chemical binding]; other site
568819004976	protein IIAGlc interface [polypeptide binding]; other site
568819004977	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
568819004978	amphipathic channel; other site
568819004979	Asn-Pro-Ala signature motifs; other site
568819004980	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
568819004981	hypothetical protein; Provisional; Region: PRK14553
568819004982	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
568819004983	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
568819004984	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
568819004985	homodimer interface [polypeptide binding]; other site
568819004986	oligonucleotide binding site [chemical binding]; other site
568819004987	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
568819004988	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
568819004989	Switch I; other site
568819004990	Switch II; other site
568819004991	septum formation inhibitor; Reviewed; Region: minC; PRK00513
568819004992	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
568819004993	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
568819004994	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
568819004995	Protein of unknown function (DUF972); Region: DUF972; pfam06156
568819004996	rod shape-determining protein MreC; Region: MreC; pfam04085
568819004997	rod shape-determining protein MreB; Provisional; Region: PRK13927
568819004998	MreB and similar proteins; Region: MreB_like; cd10225
568819004999	nucleotide binding site [chemical binding]; other site
568819005000	Mg binding site [ion binding]; other site
568819005001	putative protofilament interaction site [polypeptide binding]; other site
568819005002	RodZ interaction site [polypeptide binding]; other site
568819005003	hypothetical protein; Reviewed; Region: PRK00024
568819005004	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
568819005005	MPN+ (JAMM) motif; other site
568819005006	Zinc-binding site [ion binding]; other site
568819005007	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
568819005008	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
568819005009	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
568819005010	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819005011	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819005012	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
568819005013	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568819005014	active site
568819005015	HIGH motif; other site
568819005016	nucleotide binding site [chemical binding]; other site
568819005017	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
568819005018	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
568819005019	active site
568819005020	KMSKS motif; other site
568819005021	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
568819005022	tRNA binding surface [nucleotide binding]; other site
568819005023	anticodon binding site; other site
568819005024	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
568819005025	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
568819005026	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568819005027	inhibitor-cofactor binding pocket; inhibition site
568819005028	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005029	catalytic residue [active]
568819005030	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
568819005031	dimer interface [polypeptide binding]; other site
568819005032	active site
568819005033	Schiff base residues; other site
568819005034	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
568819005035	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
568819005036	active site
568819005037	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
568819005038	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
568819005039	domain interfaces; other site
568819005040	active site
568819005041	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
568819005042	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
568819005043	tRNA; other site
568819005044	putative tRNA binding site [nucleotide binding]; other site
568819005045	putative NADP binding site [chemical binding]; other site
568819005046	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
568819005047	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
568819005048	G1 box; other site
568819005049	GTP/Mg2+ binding site [chemical binding]; other site
568819005050	Switch I region; other site
568819005051	G2 box; other site
568819005052	G3 box; other site
568819005053	Switch II region; other site
568819005054	G4 box; other site
568819005055	G5 box; other site
568819005056	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
568819005057	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
568819005058	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
568819005059	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
568819005060	active site
568819005061	dimer interface [polypeptide binding]; other site
568819005062	motif 1; other site
568819005063	motif 2; other site
568819005064	motif 3; other site
568819005065	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
568819005066	anticodon binding site; other site
568819005067	primosomal protein DnaI; Reviewed; Region: PRK08939
568819005068	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
568819005069	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
568819005070	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568819005071	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
568819005072	ATP cone domain; Region: ATP-cone; pfam03477
568819005073	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
568819005074	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
568819005075	CoA-binding site [chemical binding]; other site
568819005076	ATP-binding [chemical binding]; other site
568819005077	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
568819005078	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
568819005079	DNA binding site [nucleotide binding]
568819005080	catalytic residue [active]
568819005081	H2TH interface [polypeptide binding]; other site
568819005082	putative catalytic residues [active]
568819005083	turnover-facilitating residue; other site
568819005084	intercalation triad [nucleotide binding]; other site
568819005085	8OG recognition residue [nucleotide binding]; other site
568819005086	putative reading head residues; other site
568819005087	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
568819005088	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568819005089	DNA polymerase I; Provisional; Region: PRK05755
568819005090	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568819005091	active site
568819005092	metal binding site 1 [ion binding]; metal-binding site
568819005093	putative 5' ssDNA interaction site; other site
568819005094	metal binding site 3; metal-binding site
568819005095	metal binding site 2 [ion binding]; metal-binding site
568819005096	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568819005097	putative DNA binding site [nucleotide binding]; other site
568819005098	putative metal binding site [ion binding]; other site
568819005099	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
568819005100	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
568819005101	active site
568819005102	DNA binding site [nucleotide binding]
568819005103	catalytic site [active]
568819005104	isocitrate dehydrogenase; Reviewed; Region: PRK07006
568819005105	isocitrate dehydrogenase; Validated; Region: PRK07362
568819005106	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
568819005107	dimer interface [polypeptide binding]; other site
568819005108	Citrate synthase; Region: Citrate_synt; pfam00285
568819005109	active site
568819005110	citrylCoA binding site [chemical binding]; other site
568819005111	oxalacetate/citrate binding site [chemical binding]; other site
568819005112	coenzyme A binding site [chemical binding]; other site
568819005113	catalytic triad [active]
568819005114	Protein of unknown function (DUF441); Region: DUF441; pfam04284
568819005115	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
568819005116	pyruvate kinase; Provisional; Region: PRK06354
568819005117	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
568819005118	domain interfaces; other site
568819005119	active site
568819005120	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
568819005121	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
568819005122	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
568819005123	active site
568819005124	ADP/pyrophosphate binding site [chemical binding]; other site
568819005125	dimerization interface [polypeptide binding]; other site
568819005126	allosteric effector site; other site
568819005127	fructose-1,6-bisphosphate binding site; other site
568819005128	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
568819005129	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
568819005130	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
568819005131	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
568819005132	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
568819005133	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
568819005134	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
568819005135	active site
568819005136	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
568819005137	generic binding surface I; other site
568819005138	generic binding surface II; other site
568819005139	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
568819005140	DHH family; Region: DHH; pfam01368
568819005141	DHHA1 domain; Region: DHHA1; pfam02272
568819005142	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
568819005143	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
568819005144	DNA-binding site [nucleotide binding]; DNA binding site
568819005145	DRTGG domain; Region: DRTGG; pfam07085
568819005146	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
568819005147	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
568819005148	active site 2 [active]
568819005149	active site 1 [active]
568819005150	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
568819005151	metal-dependent hydrolase; Provisional; Region: PRK00685
568819005152	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
568819005153	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
568819005154	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
568819005155	active site
568819005156	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
568819005157	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
568819005158	hexamer interface [polypeptide binding]; other site
568819005159	ligand binding site [chemical binding]; other site
568819005160	putative active site [active]
568819005161	NAD(P) binding site [chemical binding]; other site
568819005162	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819005163	Ligand Binding Site [chemical binding]; other site
568819005164	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
568819005165	propionate/acetate kinase; Provisional; Region: PRK12379
568819005166	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
568819005167	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005168	S-adenosylmethionine binding site [chemical binding]; other site
568819005169	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
568819005170	dimer interface [polypeptide binding]; other site
568819005171	catalytic triad [active]
568819005172	peroxidatic and resolving cysteines [active]
568819005173	RDD family; Region: RDD; pfam06271
568819005174	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
568819005175	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
568819005176	tandem repeat interface [polypeptide binding]; other site
568819005177	oligomer interface [polypeptide binding]; other site
568819005178	active site residues [active]
568819005179	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
568819005180	ATP-NAD kinase; Region: NAD_kinase; pfam01513
568819005181	ornithine carbamoyltransferase; Provisional; Region: PRK00779
568819005182	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819005183	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
568819005184	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
568819005185	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568819005186	inhibitor-cofactor binding pocket; inhibition site
568819005187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005188	catalytic residue [active]
568819005189	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
568819005190	nucleotide binding site [chemical binding]; other site
568819005191	N-acetyl-L-glutamate binding site [chemical binding]; other site
568819005192	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
568819005193	heterotetramer interface [polypeptide binding]; other site
568819005194	active site pocket [active]
568819005195	cleavage site
568819005196	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
568819005197	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
568819005198	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
568819005199	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
568819005200	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
568819005201	Ligand Binding Site [chemical binding]; other site
568819005202	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
568819005203	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568819005204	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819005205	catalytic residue [active]
568819005206	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
568819005207	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
568819005208	GAF domain; Region: GAF_2; pfam13185
568819005209	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
568819005210	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
568819005211	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819005212	RNA binding surface [nucleotide binding]; other site
568819005213	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
568819005214	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
568819005215	active site
568819005216	HIGH motif; other site
568819005217	dimer interface [polypeptide binding]; other site
568819005218	KMSKS motif; other site
568819005219	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819005220	RNA binding surface [nucleotide binding]; other site
568819005221	catabolite control protein A; Region: ccpA; TIGR01481
568819005222	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819005223	DNA binding site [nucleotide binding]
568819005224	domain linker motif; other site
568819005225	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
568819005226	dimerization interface [polypeptide binding]; other site
568819005227	effector binding site; other site
568819005228	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
568819005229	Chorismate mutase type II; Region: CM_2; cl00693
568819005230	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
568819005231	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
568819005232	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
568819005233	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
568819005234	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
568819005235	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
568819005236	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
568819005237	dimer interface [polypeptide binding]; other site
568819005238	decamer (pentamer of dimers) interface [polypeptide binding]; other site
568819005239	catalytic triad [active]
568819005240	peroxidatic and resolving cysteines [active]
568819005241	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
568819005242	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819005243	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819005244	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819005245	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
568819005246	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
568819005247	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
568819005248	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
568819005249	putative tRNA-binding site [nucleotide binding]; other site
568819005250	hypothetical protein; Provisional; Region: PRK13668
568819005251	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819005252	catalytic residues [active]
568819005253	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
568819005254	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
568819005255	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
568819005256	oligomer interface [polypeptide binding]; other site
568819005257	active site
568819005258	metal binding site [ion binding]; metal-binding site
568819005259	Predicted small secreted protein [Function unknown]; Region: COG5584
568819005260	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
568819005261	putative homodimer interface [polypeptide binding]; other site
568819005262	putative homotetramer interface [polypeptide binding]; other site
568819005263	putative allosteric switch controlling residues; other site
568819005264	putative metal binding site [ion binding]; other site
568819005265	putative homodimer-homodimer interface [polypeptide binding]; other site
568819005266	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819005267	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005268	S-adenosylmethionine binding site [chemical binding]; other site
568819005269	Phosphotransferase enzyme family; Region: APH; pfam01636
568819005270	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568819005271	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568819005272	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819005273	putative substrate translocation pore; other site
568819005274	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819005275	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819005276	MarR family; Region: MarR; pfam01047
568819005277	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568819005278	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
568819005279	homodimer interface [polypeptide binding]; other site
568819005280	substrate-cofactor binding pocket; other site
568819005281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005282	catalytic residue [active]
568819005283	dipeptidase PepV; Reviewed; Region: PRK07318
568819005284	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
568819005285	active site
568819005286	metal binding site [ion binding]; metal-binding site
568819005287	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
568819005288	nudix motif; other site
568819005289	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
568819005290	putative substrate binding site [chemical binding]; other site
568819005291	putative ATP binding site [chemical binding]; other site
568819005292	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568819005293	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568819005294	active site
568819005295	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568819005296	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568819005297	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
568819005298	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
568819005299	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
568819005300	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
568819005301	substrate binding site [chemical binding]; other site
568819005302	active site
568819005303	catalytic residues [active]
568819005304	heterodimer interface [polypeptide binding]; other site
568819005305	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
568819005306	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
568819005307	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005308	catalytic residue [active]
568819005309	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
568819005310	active site
568819005311	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
568819005312	active site
568819005313	ribulose/triose binding site [chemical binding]; other site
568819005314	phosphate binding site [ion binding]; other site
568819005315	substrate (anthranilate) binding pocket [chemical binding]; other site
568819005316	product (indole) binding pocket [chemical binding]; other site
568819005317	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
568819005318	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568819005319	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568819005320	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568819005321	Glutamine amidotransferase class-I; Region: GATase; pfam00117
568819005322	glutamine binding [chemical binding]; other site
568819005323	catalytic triad [active]
568819005324	anthranilate synthase component I; Provisional; Region: PRK13570
568819005325	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
568819005326	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
568819005327	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
568819005328	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
568819005329	putative catalytic cysteine [active]
568819005330	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
568819005331	putative active site [active]
568819005332	metal binding site [ion binding]; metal-binding site
568819005333	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819005334	dimer interface [polypeptide binding]; other site
568819005335	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819005336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819005337	Walker A/P-loop; other site
568819005338	ATP binding site [chemical binding]; other site
568819005339	Q-loop/lid; other site
568819005340	ABC transporter signature motif; other site
568819005341	Walker B; other site
568819005342	D-loop; other site
568819005343	H-loop/switch region; other site
568819005344	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568819005345	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
568819005346	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
568819005347	putative dimer interface [polypeptide binding]; other site
568819005348	catalytic triad [active]
568819005349	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
568819005350	aconitate hydratase; Validated; Region: PRK09277
568819005351	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
568819005352	substrate binding site [chemical binding]; other site
568819005353	ligand binding site [chemical binding]; other site
568819005354	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
568819005355	substrate binding site [chemical binding]; other site
568819005356	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819005357	Heat induced stress protein YflT; Region: YflT; pfam11181
568819005358	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
568819005359	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
568819005360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819005361	ATP binding site [chemical binding]; other site
568819005362	putative Mg++ binding site [ion binding]; other site
568819005363	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005364	nucleotide binding region [chemical binding]; other site
568819005365	ATP-binding site [chemical binding]; other site
568819005366	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
568819005367	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
568819005368	Walker A/P-loop; other site
568819005369	ATP binding site [chemical binding]; other site
568819005370	Q-loop/lid; other site
568819005371	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
568819005372	ABC transporter signature motif; other site
568819005373	Walker B; other site
568819005374	D-loop; other site
568819005375	H-loop/switch region; other site
568819005376	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568819005377	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568819005378	active site
568819005379	metal binding site [ion binding]; metal-binding site
568819005380	DNA binding site [nucleotide binding]
568819005381	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
568819005382	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
568819005383	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
568819005384	putative acyl-acceptor binding pocket; other site
568819005385	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
568819005386	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819005387	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819005388	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
568819005389	Walker A/P-loop; other site
568819005390	ATP binding site [chemical binding]; other site
568819005391	Q-loop/lid; other site
568819005392	ABC transporter signature motif; other site
568819005393	Walker B; other site
568819005394	D-loop; other site
568819005395	H-loop/switch region; other site
568819005396	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819005397	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
568819005398	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819005399	Walker A/P-loop; other site
568819005400	ATP binding site [chemical binding]; other site
568819005401	Q-loop/lid; other site
568819005402	ABC transporter signature motif; other site
568819005403	Walker B; other site
568819005404	D-loop; other site
568819005405	H-loop/switch region; other site
568819005406	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
568819005407	active site
568819005408	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
568819005409	elongation factor Ts; Provisional; Region: tsf; PRK09377
568819005410	UBA/TS-N domain; Region: UBA; pfam00627
568819005411	Elongation factor TS; Region: EF_TS; pfam00889
568819005412	Elongation factor TS; Region: EF_TS; pfam00889
568819005413	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
568819005414	rRNA interaction site [nucleotide binding]; other site
568819005415	S8 interaction site; other site
568819005416	putative laminin-1 binding site; other site
568819005417	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
568819005418	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568819005419	PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586
568819005420	active site turn [active]
568819005421	phosphorylation site [posttranslational modification]
568819005422	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568819005423	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
568819005424	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
568819005425	putative active site [active]
568819005426	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819005427	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819005428	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819005429	putative active site [active]
568819005430	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
568819005431	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568819005432	HIGH motif; other site
568819005433	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
568819005434	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
568819005435	active site
568819005436	KMSKS motif; other site
568819005437	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
568819005438	tRNA binding surface [nucleotide binding]; other site
568819005439	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
568819005440	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
568819005441	FeS/SAM binding site; other site
568819005442	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005443	S-adenosylmethionine binding site [chemical binding]; other site
568819005444	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
568819005445	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
568819005446	active site
568819005447	dimer interface [polypeptide binding]; other site
568819005448	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
568819005449	Ligand Binding Site [chemical binding]; other site
568819005450	Molecular Tunnel; other site
568819005451	S-adenosylmethionine synthetase; Validated; Region: PRK05250
568819005452	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
568819005453	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
568819005454	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
568819005455	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
568819005456	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
568819005457	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
568819005458	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819005459	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
568819005460	NAD binding site [chemical binding]; other site
568819005461	dimer interface [polypeptide binding]; other site
568819005462	substrate binding site [chemical binding]; other site
568819005463	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
568819005464	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
568819005465	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
568819005466	nudix motif; other site
568819005467	Uncharacterized conserved protein [Function unknown]; Region: COG0759
568819005468	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
568819005469	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
568819005470	metal binding site [ion binding]; metal-binding site
568819005471	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
568819005472	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
568819005473	acyl-activating enzyme (AAE) consensus motif; other site
568819005474	putative AMP binding site [chemical binding]; other site
568819005475	putative active site [active]
568819005476	putative CoA binding site [chemical binding]; other site
568819005477	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
568819005478	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
568819005479	substrate binding site [chemical binding]; other site
568819005480	oxyanion hole (OAH) forming residues; other site
568819005481	trimer interface [polypeptide binding]; other site
568819005482	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819005483	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
568819005484	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
568819005485	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
568819005486	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
568819005487	dimer interface [polypeptide binding]; other site
568819005488	tetramer interface [polypeptide binding]; other site
568819005489	PYR/PP interface [polypeptide binding]; other site
568819005490	TPP binding site [chemical binding]; other site
568819005491	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
568819005492	TPP-binding site; other site
568819005493	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
568819005494	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568819005495	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
568819005496	UbiA prenyltransferase family; Region: UbiA; pfam01040
568819005497	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
568819005498	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
568819005499	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
568819005500	FAD binding site [chemical binding]; other site
568819005501	cystathionine beta-lyase; Provisional; Region: PRK08064
568819005502	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819005503	homodimer interface [polypeptide binding]; other site
568819005504	substrate-cofactor binding pocket; other site
568819005505	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005506	catalytic residue [active]
568819005507	cystathionine gamma-synthase; Reviewed; Region: PRK08247
568819005508	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
568819005509	homodimer interface [polypeptide binding]; other site
568819005510	substrate-cofactor binding pocket; other site
568819005511	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005512	catalytic residue [active]
568819005513	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
568819005514	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
568819005515	THF binding site; other site
568819005516	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
568819005517	substrate binding site [chemical binding]; other site
568819005518	THF binding site; other site
568819005519	zinc-binding site [ion binding]; other site
568819005520	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819005521	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819005522	putative substrate translocation pore; other site
568819005523	ferric uptake regulator; Provisional; Region: fur; PRK09462
568819005524	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819005525	metal binding site 2 [ion binding]; metal-binding site
568819005526	putative DNA binding helix; other site
568819005527	metal binding site 1 [ion binding]; metal-binding site
568819005528	dimer interface [polypeptide binding]; other site
568819005529	structural Zn2+ binding site [ion binding]; other site
568819005530	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
568819005531	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
568819005532	NAD binding site [chemical binding]; other site
568819005533	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
568819005534	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
568819005535	inhibitor-cofactor binding pocket; inhibition site
568819005536	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819005537	catalytic residue [active]
568819005538	Predicted membrane protein [Function unknown]; Region: COG4129
568819005539	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
568819005540	hypothetical protein; Provisional; Region: PRK13662
568819005541	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
568819005542	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
568819005543	putative NAD(P) binding site [chemical binding]; other site
568819005544	active site
568819005545	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
568819005546	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819005547	minor groove reading motif; other site
568819005548	helix-hairpin-helix signature motif; other site
568819005549	substrate binding pocket [chemical binding]; other site
568819005550	active site
568819005551	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
568819005552	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
568819005553	DNA binding and oxoG recognition site [nucleotide binding]
568819005554	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
568819005555	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
568819005556	trimer interface [polypeptide binding]; other site
568819005557	active site
568819005558	WVELL protein; Region: WVELL; pfam14043
568819005559	recombination regulator RecX; Provisional; Region: recX; PRK14135
568819005560	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819005561	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
568819005562	NAD(P) binding site [chemical binding]; other site
568819005563	active site
568819005564	Predicted integral membrane protein [Function unknown]; Region: COG0392
568819005565	Uncharacterized conserved protein [Function unknown]; Region: COG2898
568819005566	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
568819005567	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
568819005568	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819005569	Cation efflux family; Region: Cation_efflux; pfam01545
568819005570	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819005571	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
568819005572	PAS fold; Region: PAS_4; pfam08448
568819005573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
568819005574	putative active site [active]
568819005575	heme pocket [chemical binding]; other site
568819005576	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
568819005577	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
568819005578	dimer interface [polypeptide binding]; other site
568819005579	putative CheW interface [polypeptide binding]; other site
568819005580	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
568819005581	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
568819005582	dimer interface [polypeptide binding]; other site
568819005583	active site
568819005584	Mn binding site [ion binding]; other site
568819005585	TRAM domain; Region: TRAM; cl01282
568819005586	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
568819005587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005588	S-adenosylmethionine binding site [chemical binding]; other site
568819005589	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
568819005590	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
568819005591	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
568819005592	Substrate-binding site [chemical binding]; other site
568819005593	Substrate specificity [chemical binding]; other site
568819005594	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
568819005595	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
568819005596	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
568819005597	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
568819005598	active site
568819005599	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
568819005600	flavodoxin, short chain; Region: flav_short; TIGR01753
568819005601	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
568819005602	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
568819005603	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819005604	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819005605	putative substrate translocation pore; other site
568819005606	rod-share determining protein MreBH; Provisional; Region: PRK13929
568819005607	MreB and similar proteins; Region: MreB_like; cd10225
568819005608	nucleotide binding site [chemical binding]; other site
568819005609	Mg binding site [ion binding]; other site
568819005610	putative protofilament interaction site [polypeptide binding]; other site
568819005611	RodZ interaction site [polypeptide binding]; other site
568819005612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005613	S-adenosylmethionine binding site [chemical binding]; other site
568819005614	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819005615	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819005616	Uncharacterized conserved protein [Function unknown]; Region: COG4748
568819005617	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
568819005618	Uncharacterized conserved protein [Function unknown]; Region: COG3589
568819005619	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
568819005620	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819005621	methionine cluster; other site
568819005622	active site
568819005623	phosphorylation site [posttranslational modification]
568819005624	metal binding site [ion binding]; metal-binding site
568819005625	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819005626	active site
568819005627	P-loop; other site
568819005628	phosphorylation site [posttranslational modification]
568819005629	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
568819005630	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
568819005631	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819005632	Walker A motif; other site
568819005633	ATP binding site [chemical binding]; other site
568819005634	Walker B motif; other site
568819005635	arginine finger; other site
568819005636	Transcriptional antiterminator [Transcription]; Region: COG3933
568819005637	PRD domain; Region: PRD; pfam00874
568819005638	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819005639	active pocket/dimerization site; other site
568819005640	active site
568819005641	phosphorylation site [posttranslational modification]
568819005642	PRD domain; Region: PRD; pfam00874
568819005643	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
568819005644	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819005645	ATP binding site [chemical binding]; other site
568819005646	putative Mg++ binding site [ion binding]; other site
568819005647	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005648	nucleotide binding region [chemical binding]; other site
568819005649	ATP-binding site [chemical binding]; other site
568819005650	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819005651	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819005652	Walker A/P-loop; other site
568819005653	ATP binding site [chemical binding]; other site
568819005654	Q-loop/lid; other site
568819005655	ABC transporter signature motif; other site
568819005656	Walker B; other site
568819005657	D-loop; other site
568819005658	H-loop/switch region; other site
568819005659	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819005660	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819005661	DNA-binding site [nucleotide binding]; DNA binding site
568819005662	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819005663	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819005664	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819005665	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819005666	DNA binding site [nucleotide binding]
568819005667	domain linker motif; other site
568819005668	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819005669	dimerization interface [polypeptide binding]; other site
568819005670	ligand binding site [chemical binding]; other site
568819005671	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
568819005672	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
568819005673	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
568819005674	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
568819005675	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819005676	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819005677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819005678	dimer interface [polypeptide binding]; other site
568819005679	conserved gate region; other site
568819005680	putative PBP binding loops; other site
568819005681	ABC-ATPase subunit interface; other site
568819005682	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819005683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819005684	dimer interface [polypeptide binding]; other site
568819005685	conserved gate region; other site
568819005686	putative PBP binding loops; other site
568819005687	ABC-ATPase subunit interface; other site
568819005688	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
568819005689	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
568819005690	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
568819005691	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
568819005692	active site
568819005693	dimer interface [polypeptide binding]; other site
568819005694	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
568819005695	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
568819005696	active site
568819005697	FMN binding site [chemical binding]; other site
568819005698	substrate binding site [chemical binding]; other site
568819005699	3Fe-4S cluster binding site [ion binding]; other site
568819005700	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
568819005701	domain interface; other site
568819005702	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819005703	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819005704	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819005705	putative dimerization interface [polypeptide binding]; other site
568819005706	Predicted acetyltransferase [General function prediction only]; Region: COG3153
568819005707	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
568819005708	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
568819005709	putative active site [active]
568819005710	metal binding site [ion binding]; metal-binding site
568819005711	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819005712	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568819005713	substrate binding pocket [chemical binding]; other site
568819005714	membrane-bound complex binding site; other site
568819005715	hinge residues; other site
568819005716	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819005717	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819005718	Walker A/P-loop; other site
568819005719	ATP binding site [chemical binding]; other site
568819005720	Q-loop/lid; other site
568819005721	ABC transporter signature motif; other site
568819005722	Walker B; other site
568819005723	D-loop; other site
568819005724	H-loop/switch region; other site
568819005725	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819005726	dimer interface [polypeptide binding]; other site
568819005727	conserved gate region; other site
568819005728	putative PBP binding loops; other site
568819005729	ABC-ATPase subunit interface; other site
568819005730	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
568819005731	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
568819005732	dimer interface [polypeptide binding]; other site
568819005733	phosphorylation site [posttranslational modification]
568819005734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819005735	ATP binding site [chemical binding]; other site
568819005736	Mg2+ binding site [ion binding]; other site
568819005737	G-X-G motif; other site
568819005738	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
568819005739	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
568819005740	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
568819005741	active site
568819005742	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
568819005743	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
568819005744	putative NAD(P) binding site [chemical binding]; other site
568819005745	active site
568819005746	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819005747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819005748	active site
568819005749	phosphorylation site [posttranslational modification]
568819005750	intermolecular recognition site; other site
568819005751	dimerization interface [polypeptide binding]; other site
568819005752	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819005753	DNA binding site [nucleotide binding]
568819005754	FtsX-like permease family; Region: FtsX; pfam02687
568819005755	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819005756	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819005757	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819005758	Walker A/P-loop; other site
568819005759	ATP binding site [chemical binding]; other site
568819005760	Q-loop/lid; other site
568819005761	ABC transporter signature motif; other site
568819005762	Walker B; other site
568819005763	D-loop; other site
568819005764	H-loop/switch region; other site
568819005765	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
568819005766	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
568819005767	ADP binding site [chemical binding]; other site
568819005768	magnesium binding site [ion binding]; other site
568819005769	putative shikimate binding site; other site
568819005770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
568819005771	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
568819005772	TRAM domain; Region: TRAM; pfam01938
568819005773	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819005774	S-adenosylmethionine binding site [chemical binding]; other site
568819005775	putative lipid kinase; Reviewed; Region: PRK13337
568819005776	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
568819005777	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
568819005778	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
568819005779	GatB domain; Region: GatB_Yqey; smart00845
568819005780	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
568819005781	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
568819005782	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
568819005783	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
568819005784	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
568819005785	putative dimer interface [polypeptide binding]; other site
568819005786	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
568819005787	putative dimer interface [polypeptide binding]; other site
568819005788	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
568819005789	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
568819005790	nucleotide binding pocket [chemical binding]; other site
568819005791	K-X-D-G motif; other site
568819005792	catalytic site [active]
568819005793	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
568819005794	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
568819005795	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
568819005796	Dimer interface [polypeptide binding]; other site
568819005797	BRCT sequence motif; other site
568819005798	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
568819005799	Part of AAA domain; Region: AAA_19; pfam13245
568819005800	Family description; Region: UvrD_C_2; pfam13538
568819005801	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
568819005802	PcrB family; Region: PcrB; pfam01884
568819005803	substrate binding site [chemical binding]; other site
568819005804	putative active site [active]
568819005805	dimer interface [polypeptide binding]; other site
568819005806	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
568819005807	Na2 binding site [ion binding]; other site
568819005808	putative substrate binding site 1 [chemical binding]; other site
568819005809	Na binding site 1 [ion binding]; other site
568819005810	putative substrate binding site 2 [chemical binding]; other site
568819005811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
568819005812	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
568819005813	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
568819005814	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
568819005815	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
568819005816	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
568819005817	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
568819005818	purine monophosphate binding site [chemical binding]; other site
568819005819	dimer interface [polypeptide binding]; other site
568819005820	putative catalytic residues [active]
568819005821	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
568819005822	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
568819005823	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
568819005824	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
568819005825	active site
568819005826	substrate binding site [chemical binding]; other site
568819005827	cosubstrate binding site; other site
568819005828	catalytic site [active]
568819005829	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
568819005830	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
568819005831	dimerization interface [polypeptide binding]; other site
568819005832	putative ATP binding site [chemical binding]; other site
568819005833	amidophosphoribosyltransferase; Provisional; Region: PRK06781
568819005834	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
568819005835	active site
568819005836	tetramer interface [polypeptide binding]; other site
568819005837	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819005838	active site
568819005839	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
568819005840	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
568819005841	dimerization interface [polypeptide binding]; other site
568819005842	ATP binding site [chemical binding]; other site
568819005843	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
568819005844	dimerization interface [polypeptide binding]; other site
568819005845	ATP binding site [chemical binding]; other site
568819005846	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
568819005847	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
568819005848	putative active site [active]
568819005849	catalytic triad [active]
568819005850	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
568819005851	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
568819005852	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
568819005853	ATP binding site [chemical binding]; other site
568819005854	active site
568819005855	substrate binding site [chemical binding]; other site
568819005856	adenylosuccinate lyase; Provisional; Region: PRK07492
568819005857	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
568819005858	tetramer interface [polypeptide binding]; other site
568819005859	active site
568819005860	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
568819005861	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
568819005862	NAD binding site [chemical binding]; other site
568819005863	ATP-grasp domain; Region: ATP-grasp; pfam02222
568819005864	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
568819005865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
568819005866	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819005867	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
568819005868	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819005869	Zn2+ binding site [ion binding]; other site
568819005870	Mg2+ binding site [ion binding]; other site
568819005871	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819005872	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568819005873	Walker A/P-loop; other site
568819005874	ATP binding site [chemical binding]; other site
568819005875	Q-loop/lid; other site
568819005876	ABC transporter signature motif; other site
568819005877	Walker B; other site
568819005878	D-loop; other site
568819005879	H-loop/switch region; other site
568819005880	peptidase T; Region: peptidase-T; TIGR01882
568819005881	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
568819005882	metal binding site [ion binding]; metal-binding site
568819005883	dimer interface [polypeptide binding]; other site
568819005884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
568819005885	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
568819005886	active site
568819005887	putative catalytic site [active]
568819005888	DNA binding site [nucleotide binding]
568819005889	putative phosphate binding site [ion binding]; other site
568819005890	metal binding site A [ion binding]; metal-binding site
568819005891	AP binding site [nucleotide binding]; other site
568819005892	metal binding site B [ion binding]; metal-binding site
568819005893	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
568819005894	23S rRNA binding site [nucleotide binding]; other site
568819005895	L21 binding site [polypeptide binding]; other site
568819005896	L13 binding site [polypeptide binding]; other site
568819005897	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
568819005898	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
568819005899	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
568819005900	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
568819005901	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819005902	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819005903	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819005904	Substrate binding site [chemical binding]; other site
568819005905	Leucine rich repeat; Region: LRR_8; pfam13855
568819005906	LRR adjacent; Region: LRR_adjacent; pfam08191
568819005907	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
568819005908	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
568819005909	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568819005910	DNA binding residues [nucleotide binding]
568819005911	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
568819005912	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568819005913	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819005914	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
568819005915	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
568819005916	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
568819005917	RimM N-terminal domain; Region: RimM; pfam01782
568819005918	PRC-barrel domain; Region: PRC; pfam05239
568819005919	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
568819005920	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
568819005921	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
568819005922	catalytic triad [active]
568819005923	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
568819005924	KH domain; Region: KH_4; pfam13083
568819005925	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
568819005926	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
568819005927	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
568819005928	signal recognition particle protein; Provisional; Region: PRK10867
568819005929	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
568819005930	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568819005931	P loop; other site
568819005932	GTP binding site [chemical binding]; other site
568819005933	Signal peptide binding domain; Region: SRP_SPB; pfam02978
568819005934	putative DNA-binding protein; Validated; Region: PRK00118
568819005935	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
568819005936	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
568819005937	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
568819005938	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
568819005939	P loop; other site
568819005940	GTP binding site [chemical binding]; other site
568819005941	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
568819005942	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
568819005943	Walker A/P-loop; other site
568819005944	ATP binding site [chemical binding]; other site
568819005945	Q-loop/lid; other site
568819005946	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
568819005947	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
568819005948	linker region; other site
568819005949	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
568819005950	ABC transporter signature motif; other site
568819005951	Walker B; other site
568819005952	D-loop; other site
568819005953	H-loop/switch region; other site
568819005954	ribonuclease III; Reviewed; Region: rnc; PRK00102
568819005955	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
568819005956	dimerization interface [polypeptide binding]; other site
568819005957	active site
568819005958	metal binding site [ion binding]; metal-binding site
568819005959	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
568819005960	dsRNA binding site [nucleotide binding]; other site
568819005961	acyl carrier protein; Provisional; Region: acpP; PRK00982
568819005962	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568819005963	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
568819005964	NAD(P) binding site [chemical binding]; other site
568819005965	homotetramer interface [polypeptide binding]; other site
568819005966	homodimer interface [polypeptide binding]; other site
568819005967	active site
568819005968	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
568819005969	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
568819005970	putative phosphate acyltransferase; Provisional; Region: PRK05331
568819005971	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
568819005972	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
568819005973	active site 2 [active]
568819005974	active site 1 [active]
568819005975	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
568819005976	Y-family of DNA polymerases; Region: PolY; cl12025
568819005977	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
568819005978	generic binding surface II; other site
568819005979	ssDNA binding site; other site
568819005980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819005981	ATP binding site [chemical binding]; other site
568819005982	putative Mg++ binding site [ion binding]; other site
568819005983	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819005984	nucleotide binding region [chemical binding]; other site
568819005985	ATP-binding site [chemical binding]; other site
568819005986	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
568819005987	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
568819005988	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
568819005989	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
568819005990	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
568819005991	putative L-serine binding site [chemical binding]; other site
568819005992	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
568819005993	DAK2 domain; Region: Dak2; pfam02734
568819005994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
568819005995	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
568819005996	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
568819005997	Thiamine pyrophosphokinase; Region: TPK; cd07995
568819005998	active site
568819005999	dimerization interface [polypeptide binding]; other site
568819006000	thiamine binding site [chemical binding]; other site
568819006001	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819006002	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568819006003	substrate binding site [chemical binding]; other site
568819006004	hexamer interface [polypeptide binding]; other site
568819006005	metal binding site [ion binding]; metal-binding site
568819006006	GTPase RsgA; Reviewed; Region: PRK00098
568819006007	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
568819006008	RNA binding site [nucleotide binding]; other site
568819006009	homodimer interface [polypeptide binding]; other site
568819006010	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
568819006011	GTPase/Zn-binding domain interface [polypeptide binding]; other site
568819006012	GTP/Mg2+ binding site [chemical binding]; other site
568819006013	G4 box; other site
568819006014	G1 box; other site
568819006015	Switch I region; other site
568819006016	G2 box; other site
568819006017	G3 box; other site
568819006018	Switch II region; other site
568819006019	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
568819006020	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
568819006021	active site
568819006022	ATP binding site [chemical binding]; other site
568819006023	substrate binding site [chemical binding]; other site
568819006024	activation loop (A-loop); other site
568819006025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
568819006026	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
568819006027	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
568819006028	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
568819006029	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
568819006030	Protein phosphatase 2C; Region: PP2C; pfam00481
568819006031	active site
568819006032	16S rRNA methyltransferase B; Provisional; Region: PRK14902
568819006033	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
568819006034	putative RNA binding site [nucleotide binding]; other site
568819006035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819006036	S-adenosylmethionine binding site [chemical binding]; other site
568819006037	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
568819006038	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
568819006039	putative active site [active]
568819006040	substrate binding site [chemical binding]; other site
568819006041	putative cosubstrate binding site; other site
568819006042	catalytic site [active]
568819006043	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
568819006044	substrate binding site [chemical binding]; other site
568819006045	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
568819006046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819006047	ATP binding site [chemical binding]; other site
568819006048	putative Mg++ binding site [ion binding]; other site
568819006049	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819006050	ATP-binding site [chemical binding]; other site
568819006051	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
568819006052	Flavoprotein; Region: Flavoprotein; pfam02441
568819006053	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
568819006054	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
568819006055	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
568819006056	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
568819006057	catalytic site [active]
568819006058	G-X2-G-X-G-K; other site
568819006059	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
568819006060	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
568819006061	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
568819006062	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
568819006063	Domain of unknown function (DUF814); Region: DUF814; pfam05670
568819006064	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
568819006065	putative NAD(P) binding site [chemical binding]; other site
568819006066	homodimer interface [polypeptide binding]; other site
568819006067	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819006068	active site
568819006069	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
568819006070	active site
568819006071	dimer interface [polypeptide binding]; other site
568819006072	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
568819006073	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
568819006074	heterodimer interface [polypeptide binding]; other site
568819006075	active site
568819006076	FMN binding site [chemical binding]; other site
568819006077	homodimer interface [polypeptide binding]; other site
568819006078	substrate binding site [chemical binding]; other site
568819006079	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
568819006080	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
568819006081	FAD binding pocket [chemical binding]; other site
568819006082	FAD binding motif [chemical binding]; other site
568819006083	phosphate binding motif [ion binding]; other site
568819006084	beta-alpha-beta structure motif; other site
568819006085	NAD binding pocket [chemical binding]; other site
568819006086	Iron coordination center [ion binding]; other site
568819006087	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
568819006088	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819006089	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
568819006090	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
568819006091	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
568819006092	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568819006093	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
568819006094	IMP binding site; other site
568819006095	dimer interface [polypeptide binding]; other site
568819006096	interdomain contacts; other site
568819006097	partial ornithine binding site; other site
568819006098	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
568819006099	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
568819006100	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
568819006101	catalytic site [active]
568819006102	subunit interface [polypeptide binding]; other site
568819006103	dihydroorotase; Validated; Region: pyrC; PRK09357
568819006104	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
568819006105	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
568819006106	active site
568819006107	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
568819006108	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
568819006109	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
568819006110	uracil transporter; Provisional; Region: PRK10720
568819006111	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
568819006112	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819006113	active site
568819006114	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
568819006115	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568819006116	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819006117	RNA binding surface [nucleotide binding]; other site
568819006118	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568819006119	active site
568819006120	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
568819006121	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568819006122	Sulfate transporter family; Region: Sulfate_transp; pfam00916
568819006123	multidrug efflux protein; Reviewed; Region: PRK01766
568819006124	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
568819006125	cation binding site [ion binding]; other site
568819006126	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
568819006127	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
568819006128	metal binding site [ion binding]; metal-binding site
568819006129	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
568819006130	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819006131	ABC-ATPase subunit  interface; other site
568819006132	dimer interface [polypeptide binding]; other site
568819006133	putative PBP binding regions; other site
568819006134	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
568819006135	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
568819006136	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819006137	MarR family; Region: MarR; pfam01047
568819006138	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
568819006139	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
568819006140	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
568819006141	protein binding site [polypeptide binding]; other site
568819006142	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
568819006143	Catalytic dyad [active]
568819006144	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
568819006145	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568819006146	metal-binding site [ion binding]
568819006147	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
568819006148	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
568819006149	metal-binding site [ion binding]
568819006150	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819006151	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819006152	motif II; other site
568819006153	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
568819006154	putative homodimer interface [polypeptide binding]; other site
568819006155	putative homotetramer interface [polypeptide binding]; other site
568819006156	putative allosteric switch controlling residues; other site
568819006157	putative metal binding site [ion binding]; other site
568819006158	putative homodimer-homodimer interface [polypeptide binding]; other site
568819006159	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
568819006160	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
568819006161	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
568819006162	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
568819006163	hypothetical protein; Provisional; Region: PRK13672
568819006164	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819006165	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819006166	methionine sulfoxide reductase B; Provisional; Region: PRK00222
568819006167	SelR domain; Region: SelR; pfam01641
568819006168	methionine sulfoxide reductase A; Provisional; Region: PRK14054
568819006169	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
568819006170	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
568819006171	active site
568819006172	catalytic triad [active]
568819006173	oxyanion hole [active]
568819006174	EDD domain protein, DegV family; Region: DegV; TIGR00762
568819006175	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568819006176	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
568819006177	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
568819006178	HTH domain; Region: HTH_11; pfam08279
568819006179	FOG: CBS domain [General function prediction only]; Region: COG0517
568819006180	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
568819006181	PEP synthetase regulatory protein; Provisional; Region: PRK05339
568819006182	pyruvate phosphate dikinase; Provisional; Region: PRK09279
568819006183	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
568819006184	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
568819006185	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
568819006186	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819006187	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
568819006188	Predicted membrane protein [Function unknown]; Region: COG4129
568819006189	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
568819006190	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
568819006191	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
568819006192	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
568819006193	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
568819006194	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
568819006195	Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728
568819006196	Clostridial hydrophobic W; Region: ChW; pfam07538
568819006197	Clostridial hydrophobic W; Region: ChW; pfam07538
568819006198	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
568819006199	active site
568819006200	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
568819006201	substrate binding site [chemical binding]; other site
568819006202	metal binding site [ion binding]; metal-binding site
568819006203	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
568819006204	Methyltransferase domain; Region: Methyltransf_18; pfam12847
568819006205	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
568819006206	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
568819006207	folate binding site [chemical binding]; other site
568819006208	NADP+ binding site [chemical binding]; other site
568819006209	thymidylate synthase; Region: thym_sym; TIGR03284
568819006210	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
568819006211	dimerization interface [polypeptide binding]; other site
568819006212	active site
568819006213	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819006214	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568819006215	Walker A/P-loop; other site
568819006216	ATP binding site [chemical binding]; other site
568819006217	Q-loop/lid; other site
568819006218	ABC transporter signature motif; other site
568819006219	Walker B; other site
568819006220	D-loop; other site
568819006221	H-loop/switch region; other site
568819006222	ABC transporter; Region: ABC_tran_2; pfam12848
568819006223	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819006224	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
568819006225	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
568819006226	Potassium binding sites [ion binding]; other site
568819006227	Cesium cation binding sites [ion binding]; other site
568819006228	manganese transport transcriptional regulator; Provisional; Region: PRK03902
568819006229	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
568819006230	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
568819006231	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568819006232	DNA-binding site [nucleotide binding]; DNA binding site
568819006233	RNA-binding motif; other site
568819006234	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
568819006235	RNA/DNA hybrid binding site [nucleotide binding]; other site
568819006236	active site
568819006237	5'-3' exonuclease; Region: 53EXOc; smart00475
568819006238	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
568819006239	active site
568819006240	metal binding site 1 [ion binding]; metal-binding site
568819006241	putative 5' ssDNA interaction site; other site
568819006242	metal binding site 3; metal-binding site
568819006243	metal binding site 2 [ion binding]; metal-binding site
568819006244	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
568819006245	putative DNA binding site [nucleotide binding]; other site
568819006246	putative metal binding site [ion binding]; other site
568819006247	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
568819006248	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
568819006249	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
568819006250	putative active site [active]
568819006251	xanthine permease; Region: pbuX; TIGR03173
568819006252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819006253	active site
568819006254	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
568819006255	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
568819006256	active site
568819006257	Zn binding site [ion binding]; other site
568819006258	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
568819006259	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
568819006260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
568819006261	cell division protein GpsB; Provisional; Region: PRK14127
568819006262	DivIVA domain; Region: DivI1A_domain; TIGR03544
568819006263	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
568819006264	hypothetical protein; Provisional; Region: PRK13660
568819006265	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
568819006266	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
568819006267	Transglycosylase; Region: Transgly; pfam00912
568819006268	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568819006269	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568819006270	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
568819006271	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
568819006272	minor groove reading motif; other site
568819006273	helix-hairpin-helix signature motif; other site
568819006274	substrate binding pocket [chemical binding]; other site
568819006275	active site
568819006276	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
568819006277	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
568819006278	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
568819006279	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
568819006280	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
568819006281	putative dimer interface [polypeptide binding]; other site
568819006282	putative anticodon binding site; other site
568819006283	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
568819006284	homodimer interface [polypeptide binding]; other site
568819006285	motif 1; other site
568819006286	motif 2; other site
568819006287	active site
568819006288	motif 3; other site
568819006289	aspartate aminotransferase; Provisional; Region: PRK05764
568819006290	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819006291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006292	homodimer interface [polypeptide binding]; other site
568819006293	catalytic residue [active]
568819006294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
568819006295	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
568819006296	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
568819006297	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
568819006298	active site
568819006299	catalytic site [active]
568819006300	substrate binding site [chemical binding]; other site
568819006301	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
568819006302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
568819006303	putative Mg++ binding site [ion binding]; other site
568819006304	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
568819006305	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
568819006306	tetramerization interface [polypeptide binding]; other site
568819006307	active site
568819006308	pantoate--beta-alanine ligase; Region: panC; TIGR00018
568819006309	Pantoate-beta-alanine ligase; Region: PanC; cd00560
568819006310	active site
568819006311	ATP-binding site [chemical binding]; other site
568819006312	pantoate-binding site; other site
568819006313	HXXH motif; other site
568819006314	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
568819006315	active site
568819006316	oligomerization interface [polypeptide binding]; other site
568819006317	metal binding site [ion binding]; metal-binding site
568819006318	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819006319	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568819006320	catalytic residues [active]
568819006321	Biotin operon repressor [Transcription]; Region: BirA; COG1654
568819006322	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
568819006323	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
568819006324	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
568819006325	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
568819006326	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
568819006327	active site
568819006328	NTP binding site [chemical binding]; other site
568819006329	metal binding triad [ion binding]; metal-binding site
568819006330	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
568819006331	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
568819006332	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
568819006333	active site
568819006334	dimer interfaces [polypeptide binding]; other site
568819006335	catalytic residues [active]
568819006336	dihydrodipicolinate reductase; Provisional; Region: PRK00048
568819006337	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
568819006338	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
568819006339	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
568819006340	homodimer interface [polypeptide binding]; other site
568819006341	metal binding site [ion binding]; metal-binding site
568819006342	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819006343	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819006344	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819006345	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819006346	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
568819006347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568819006348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819006349	metal binding site [ion binding]; metal-binding site
568819006350	active site
568819006351	I-site; other site
568819006352	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568819006353	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568819006354	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819006355	metal binding site [ion binding]; metal-binding site
568819006356	active site
568819006357	I-site; other site
568819006358	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
568819006359	malate dehydrogenase; Provisional; Region: PRK13529
568819006360	Malic enzyme, N-terminal domain; Region: malic; pfam00390
568819006361	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
568819006362	NAD(P) binding pocket [chemical binding]; other site
568819006363	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
568819006364	Beta-lactamase; Region: Beta-lactamase; pfam00144
568819006365	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
568819006366	Pyruvate formate lyase 1; Region: PFL1; cd01678
568819006367	coenzyme A binding site [chemical binding]; other site
568819006368	active site
568819006369	catalytic residues [active]
568819006370	glycine loop; other site
568819006371	HI0933-like protein; Region: HI0933_like; pfam03486
568819006372	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819006373	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
568819006374	Predicted membrane protein [Function unknown]; Region: COG4347
568819006375	hypothetical protein; Provisional; Region: PRK03636
568819006376	UPF0302 domain; Region: UPF0302; pfam08864
568819006377	IDEAL domain; Region: IDEAL; pfam08858
568819006378	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568819006379	binding surface
568819006380	TPR motif; other site
568819006381	TPR repeat; Region: TPR_11; pfam13414
568819006382	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819006383	binding surface
568819006384	TPR motif; other site
568819006385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
568819006386	binding surface
568819006387	TPR motif; other site
568819006388	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
568819006389	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
568819006390	hinge; other site
568819006391	active site
568819006392	prephenate dehydrogenase; Validated; Region: PRK06545
568819006393	prephenate dehydrogenase; Validated; Region: PRK08507
568819006394	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
568819006395	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
568819006396	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819006397	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006398	homodimer interface [polypeptide binding]; other site
568819006399	catalytic residue [active]
568819006400	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
568819006401	homotrimer interaction site [polypeptide binding]; other site
568819006402	active site
568819006403	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
568819006404	active site
568819006405	dimer interface [polypeptide binding]; other site
568819006406	metal binding site [ion binding]; metal-binding site
568819006407	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
568819006408	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
568819006409	Tetramer interface [polypeptide binding]; other site
568819006410	active site
568819006411	FMN-binding site [chemical binding]; other site
568819006412	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
568819006413	active site
568819006414	multimer interface [polypeptide binding]; other site
568819006415	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568819006416	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819006417	substrate binding pocket [chemical binding]; other site
568819006418	chain length determination region; other site
568819006419	substrate-Mg2+ binding site; other site
568819006420	catalytic residues [active]
568819006421	aspartate-rich region 1; other site
568819006422	active site lid residues [active]
568819006423	aspartate-rich region 2; other site
568819006424	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
568819006425	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819006426	S-adenosylmethionine binding site [chemical binding]; other site
568819006427	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
568819006428	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
568819006429	homodecamer interface [polypeptide binding]; other site
568819006430	GTP cyclohydrolase I; Provisional; Region: PLN03044
568819006431	active site
568819006432	putative catalytic site residues [active]
568819006433	zinc binding site [ion binding]; other site
568819006434	GTP-CH-I/GFRP interaction surface; other site
568819006435	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
568819006436	IHF dimer interface [polypeptide binding]; other site
568819006437	IHF - DNA interface [nucleotide binding]; other site
568819006438	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
568819006439	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
568819006440	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
568819006441	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
568819006442	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
568819006443	GTP-binding protein Der; Reviewed; Region: PRK00093
568819006444	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
568819006445	G1 box; other site
568819006446	GTP/Mg2+ binding site [chemical binding]; other site
568819006447	Switch I region; other site
568819006448	G2 box; other site
568819006449	Switch II region; other site
568819006450	G3 box; other site
568819006451	G4 box; other site
568819006452	G5 box; other site
568819006453	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
568819006454	G1 box; other site
568819006455	GTP/Mg2+ binding site [chemical binding]; other site
568819006456	Switch I region; other site
568819006457	G2 box; other site
568819006458	G3 box; other site
568819006459	Switch II region; other site
568819006460	G4 box; other site
568819006461	G5 box; other site
568819006462	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
568819006463	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
568819006464	RNA binding site [nucleotide binding]; other site
568819006465	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
568819006466	RNA binding site [nucleotide binding]; other site
568819006467	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
568819006468	RNA binding site [nucleotide binding]; other site
568819006469	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
568819006470	RNA binding site [nucleotide binding]; other site
568819006471	cytidylate kinase; Provisional; Region: cmk; PRK00023
568819006472	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
568819006473	CMP-binding site; other site
568819006474	The sites determining sugar specificity; other site
568819006475	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
568819006476	active site
568819006477	homotetramer interface [polypeptide binding]; other site
568819006478	homodimer interface [polypeptide binding]; other site
568819006479	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819006480	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
568819006481	DEAD-like helicases superfamily; Region: DEXDc; smart00487
568819006482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819006483	ATP binding site [chemical binding]; other site
568819006484	putative Mg++ binding site [ion binding]; other site
568819006485	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819006486	nucleotide binding region [chemical binding]; other site
568819006487	ATP-binding site [chemical binding]; other site
568819006488	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
568819006489	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
568819006490	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006491	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006492	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006493	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006494	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006495	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006496	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
568819006497	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819006498	Predicted membrane protein [Function unknown]; Region: COG3601
568819006499	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
568819006500	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
568819006501	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819006502	dimerization interface [polypeptide binding]; other site
568819006503	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568819006504	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819006505	dimer interface [polypeptide binding]; other site
568819006506	phosphorylation site [posttranslational modification]
568819006507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819006508	ATP binding site [chemical binding]; other site
568819006509	Mg2+ binding site [ion binding]; other site
568819006510	G-X-G motif; other site
568819006511	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819006512	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819006513	active site
568819006514	phosphorylation site [posttranslational modification]
568819006515	intermolecular recognition site; other site
568819006516	dimerization interface [polypeptide binding]; other site
568819006517	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819006518	DNA binding site [nucleotide binding]
568819006519	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568819006520	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819006521	RNA binding surface [nucleotide binding]; other site
568819006522	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
568819006523	active site
568819006524	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
568819006525	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
568819006526	diaminopimelate decarboxylase; Region: lysA; TIGR01048
568819006527	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
568819006528	active site
568819006529	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819006530	substrate binding site [chemical binding]; other site
568819006531	catalytic residues [active]
568819006532	dimer interface [polypeptide binding]; other site
568819006533	purine nucleoside phosphorylase; Provisional; Region: PRK08202
568819006534	phosphopentomutase; Provisional; Region: PRK05362
568819006535	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
568819006536	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
568819006537	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
568819006538	active site
568819006539	Int/Topo IB signature motif; other site
568819006540	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
568819006541	metal binding site 2 [ion binding]; metal-binding site
568819006542	putative DNA binding helix; other site
568819006543	metal binding site 1 [ion binding]; metal-binding site
568819006544	dimer interface [polypeptide binding]; other site
568819006545	structural Zn2+ binding site [ion binding]; other site
568819006546	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568819006547	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819006548	ABC-ATPase subunit  interface; other site
568819006549	dimer interface [polypeptide binding]; other site
568819006550	putative PBP binding regions; other site
568819006551	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568819006552	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819006553	ABC-ATPase subunit  interface; other site
568819006554	dimer interface [polypeptide binding]; other site
568819006555	putative PBP binding regions; other site
568819006556	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
568819006557	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
568819006558	putative ligand binding residues [chemical binding]; other site
568819006559	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819006560	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819006561	Walker A/P-loop; other site
568819006562	ATP binding site [chemical binding]; other site
568819006563	Q-loop/lid; other site
568819006564	ABC transporter signature motif; other site
568819006565	Walker B; other site
568819006566	D-loop; other site
568819006567	H-loop/switch region; other site
568819006568	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568819006569	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819006570	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006571	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006572	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
568819006573	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568819006574	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819006575	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819006576	Walker A/P-loop; other site
568819006577	ATP binding site [chemical binding]; other site
568819006578	Q-loop/lid; other site
568819006579	ABC transporter signature motif; other site
568819006580	Walker B; other site
568819006581	D-loop; other site
568819006582	H-loop/switch region; other site
568819006583	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
568819006584	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
568819006585	dimer interface [polypeptide binding]; other site
568819006586	ADP-ribose binding site [chemical binding]; other site
568819006587	active site
568819006588	nudix motif; other site
568819006589	metal binding site [ion binding]; metal-binding site
568819006590	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
568819006591	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
568819006592	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
568819006593	active site
568819006594	DNA polymerase IV; Validated; Region: PRK02406
568819006595	DNA binding site [nucleotide binding]
568819006596	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
568819006597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
568819006598	NAD(P) binding site [chemical binding]; other site
568819006599	active site
568819006600	ribonuclease Z; Region: RNase_Z; TIGR02651
568819006601	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
568819006602	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
568819006603	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
568819006604	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
568819006605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568819006606	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819006607	Coenzyme A binding pocket [chemical binding]; other site
568819006608	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
568819006609	6-phosphogluconate dehydratase; Region: edd; TIGR01196
568819006610	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
568819006611	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819006612	PYR/PP interface [polypeptide binding]; other site
568819006613	dimer interface [polypeptide binding]; other site
568819006614	TPP binding site [chemical binding]; other site
568819006615	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819006616	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
568819006617	TPP-binding site [chemical binding]; other site
568819006618	dimer interface [polypeptide binding]; other site
568819006619	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
568819006620	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
568819006621	putative valine binding site [chemical binding]; other site
568819006622	dimer interface [polypeptide binding]; other site
568819006623	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
568819006624	ketol-acid reductoisomerase; Provisional; Region: PRK05479
568819006625	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
568819006626	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
568819006627	2-isopropylmalate synthase; Validated; Region: PRK00915
568819006628	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
568819006629	active site
568819006630	catalytic residues [active]
568819006631	metal binding site [ion binding]; metal-binding site
568819006632	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
568819006633	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
568819006634	tartrate dehydrogenase; Region: TTC; TIGR02089
568819006635	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
568819006636	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
568819006637	substrate binding site [chemical binding]; other site
568819006638	ligand binding site [chemical binding]; other site
568819006639	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
568819006640	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
568819006641	substrate binding site [chemical binding]; other site
568819006642	threonine dehydratase; Validated; Region: PRK08639
568819006643	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
568819006644	tetramer interface [polypeptide binding]; other site
568819006645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819006646	catalytic residue [active]
568819006647	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
568819006648	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
568819006649	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
568819006650	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
568819006651	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
568819006652	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
568819006653	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819006654	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819006655	DNA binding site [nucleotide binding]
568819006656	domain linker motif; other site
568819006657	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819006658	dimerization interface [polypeptide binding]; other site
568819006659	ligand binding site [chemical binding]; other site
568819006660	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
568819006661	intersubunit interface [polypeptide binding]; other site
568819006662	active site
568819006663	catalytic residue [active]
568819006664	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819006665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
568819006666	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819006667	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
568819006668	active pocket/dimerization site; other site
568819006669	active site
568819006670	phosphorylation site [posttranslational modification]
568819006671	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819006672	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
568819006673	putative active site [active]
568819006674	SIS domain; Region: SIS; pfam01380
568819006675	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
568819006676	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
568819006677	dimer interface [polypeptide binding]; other site
568819006678	active site
568819006679	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
568819006680	dimer interface [polypeptide binding]; other site
568819006681	active site
568819006682	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
568819006683	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
568819006684	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
568819006685	active site
568819006686	phosphorylation site [posttranslational modification]
568819006687	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819006688	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006689	DNA-binding site [nucleotide binding]; DNA binding site
568819006690	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
568819006691	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819006692	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819006693	DNA-binding site [nucleotide binding]; DNA binding site
568819006694	UTRA domain; Region: UTRA; pfam07702
568819006695	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819006696	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819006697	active site
568819006698	catalytic tetrad [active]
568819006699	acetolactate synthase; Reviewed; Region: PRK08617
568819006700	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
568819006701	PYR/PP interface [polypeptide binding]; other site
568819006702	dimer interface [polypeptide binding]; other site
568819006703	TPP binding site [chemical binding]; other site
568819006704	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
568819006705	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
568819006706	TPP-binding site [chemical binding]; other site
568819006707	dimer interface [polypeptide binding]; other site
568819006708	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819006709	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
568819006710	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
568819006711	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819006712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819006713	dimer interface [polypeptide binding]; other site
568819006714	conserved gate region; other site
568819006715	ABC-ATPase subunit interface; other site
568819006716	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
568819006717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819006718	dimer interface [polypeptide binding]; other site
568819006719	conserved gate region; other site
568819006720	ABC-ATPase subunit interface; other site
568819006723	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
568819006724	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
568819006725	dimerization interface [polypeptide binding]; other site
568819006726	Histidine kinase; Region: His_kinase; pfam06580
568819006727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819006728	ATP binding site [chemical binding]; other site
568819006729	Mg2+ binding site [ion binding]; other site
568819006730	G-X-G motif; other site
568819006731	Predicted integral membrane protein [Function unknown]; Region: COG5578
568819006732	Uncharacterized conserved protein [Function unknown]; Region: COG3538
568819006733	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
568819006734	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819006735	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
568819006736	active site
568819006737	metal binding site [ion binding]; metal-binding site
568819006738	homodimer interface [polypeptide binding]; other site
568819006739	catalytic site [active]
568819006740	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
568819006741	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
568819006742	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
568819006743	active site
568819006744	catalytic site [active]
568819006745	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
568819006746	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
568819006747	DNA-binding site [nucleotide binding]; DNA binding site
568819006748	RNA-binding motif; other site
568819006749	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
568819006750	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
568819006751	active site
568819006752	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
568819006753	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568819006754	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
568819006755	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
568819006756	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
568819006757	active site
568819006758	HIGH motif; other site
568819006759	nucleotide binding site [chemical binding]; other site
568819006760	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
568819006761	active site
568819006762	KMSKS motif; other site
568819006763	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
568819006764	tRNA binding surface [nucleotide binding]; other site
568819006765	anticodon binding site; other site
568819006766	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
568819006767	DivIVA protein; Region: DivIVA; pfam05103
568819006768	DivIVA domain; Region: DivI1A_domain; TIGR03544
568819006769	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
568819006770	HTH domain; Region: HTH_11; pfam08279
568819006771	3H domain; Region: 3H; pfam02829
568819006772	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
568819006773	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
568819006774	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819006775	catalytic residue [active]
568819006776	L-aspartate oxidase; Provisional; Region: PRK08071
568819006777	L-aspartate oxidase; Provisional; Region: PRK06175
568819006778	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
568819006779	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
568819006780	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
568819006781	dimerization interface [polypeptide binding]; other site
568819006782	active site
568819006783	quinolinate synthetase; Provisional; Region: PRK09375
568819006784	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006785	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006786	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006787	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006788	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006789	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006790	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006791	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006792	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819006793	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006794	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006795	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006796	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006797	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006798	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006799	Leucine rich repeat; Region: LRR_8; pfam13855
568819006800	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819006801	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006802	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006803	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006804	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006805	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006806	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006807	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006808	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006809	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006810	Leucine rich repeat; Region: LRR_8; pfam13855
568819006811	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819006812	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006813	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006814	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006815	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006816	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006817	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006818	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
568819006819	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006820	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006821	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006822	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
568819006823	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
568819006824	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819006825	Methyltransferase domain; Region: Methyltransf_31; pfam13847
568819006826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819006827	S-adenosylmethionine binding site [chemical binding]; other site
568819006828	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006829	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006830	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
568819006831	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819006832	RNA binding surface [nucleotide binding]; other site
568819006833	YGGT family; Region: YGGT; pfam02325
568819006834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
568819006835	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
568819006836	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
568819006837	catalytic residue [active]
568819006838	cell division protein FtsZ; Validated; Region: PRK09330
568819006839	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
568819006840	nucleotide binding site [chemical binding]; other site
568819006841	SulA interaction site; other site
568819006842	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
568819006843	Cell division protein FtsA; Region: FtsA; smart00842
568819006844	Cell division protein FtsA; Region: FtsA; pfam14450
568819006845	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
568819006846	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
568819006847	Cell division protein FtsQ; Region: FtsQ; pfam03799
568819006848	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
568819006849	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
568819006850	active site
568819006851	homodimer interface [polypeptide binding]; other site
568819006852	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
568819006853	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819006854	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819006855	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
568819006856	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
568819006857	Mg++ binding site [ion binding]; other site
568819006858	putative catalytic motif [active]
568819006859	putative substrate binding site [chemical binding]; other site
568819006860	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
568819006861	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
568819006862	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
568819006863	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
568819006864	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
568819006865	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
568819006866	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568819006867	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
568819006868	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
568819006869	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
568819006870	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
568819006871	MraW methylase family; Region: Methyltransf_5; pfam01795
568819006872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
568819006873	MraZ protein; Region: MraZ; pfam02381
568819006874	MraZ protein; Region: MraZ; pfam02381
568819006875	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819006876	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819006877	putative substrate translocation pore; other site
568819006878	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
568819006879	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
568819006880	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
568819006881	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
568819006882	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
568819006883	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
568819006884	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
568819006885	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
568819006886	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
568819006887	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
568819006888	hypothetical protein; Provisional; Region: PRK13670
568819006889	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568819006890	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568819006891	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
568819006892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819006893	Walker A/P-loop; other site
568819006894	ATP binding site [chemical binding]; other site
568819006895	Q-loop/lid; other site
568819006896	ABC transporter signature motif; other site
568819006897	Walker B; other site
568819006898	D-loop; other site
568819006899	H-loop/switch region; other site
568819006900	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
568819006901	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
568819006902	protein binding site [polypeptide binding]; other site
568819006903	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
568819006904	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
568819006905	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
568819006906	active site
568819006907	(T/H)XGH motif; other site
568819006908	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
568819006909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819006910	S-adenosylmethionine binding site [chemical binding]; other site
568819006911	hypothetical protein; Provisional; Region: PRK02886
568819006912	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
568819006913	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
568819006914	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
568819006915	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
568819006916	UbiA prenyltransferase family; Region: UbiA; pfam01040
568819006917	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
568819006918	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
568819006919	Ion transport protein; Region: Ion_trans; pfam00520
568819006920	Ion channel; Region: Ion_trans_2; pfam07885
568819006921	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
568819006922	MOSC domain; Region: MOSC; pfam03473
568819006923	3-alpha domain; Region: 3-alpha; pfam03475
568819006924	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
568819006925	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
568819006926	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
568819006927	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
568819006928	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
568819006929	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
568819006930	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
568819006931	active site
568819006932	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
568819006933	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
568819006934	ring oligomerisation interface [polypeptide binding]; other site
568819006935	ATP/Mg binding site [chemical binding]; other site
568819006936	stacking interactions; other site
568819006937	hinge regions; other site
568819006938	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
568819006939	oligomerisation interface [polypeptide binding]; other site
568819006940	mobile loop; other site
568819006941	roof hairpin; other site
568819006942	CAAX protease self-immunity; Region: Abi; pfam02517
568819006943	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
568819006944	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
568819006945	CoA binding domain; Region: CoA_binding; pfam02629
568819006946	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819006947	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819006948	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819006949	ABC transporter; Region: ABC_tran_2; pfam12848
568819006950	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819006951	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819006952	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819006953	UGMP family protein; Validated; Region: PRK09604
568819006954	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
568819006955	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
568819006956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819006957	Coenzyme A binding pocket [chemical binding]; other site
568819006958	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
568819006959	Glycoprotease family; Region: Peptidase_M22; pfam00814
568819006960	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
568819006961	camphor resistance protein CrcB; Provisional; Region: PRK14214
568819006962	camphor resistance protein CrcB; Provisional; Region: PRK14231
568819006963	Uncharacterized conserved protein [Function unknown]; Region: COG4832
568819006964	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
568819006965	Phosphotransferase enzyme family; Region: APH; pfam01636
568819006966	active site
568819006967	substrate binding site [chemical binding]; other site
568819006968	ATP binding site [chemical binding]; other site
568819006969	Cna protein B-type domain; Region: Cna_B; pfam05738
568819006970	Cna protein B-type domain; Region: Cna_B; pfam05738
568819006971	Cna protein B-type domain; Region: Cna_B; pfam05738
568819006972	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819006973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819006974	non-specific DNA binding site [nucleotide binding]; other site
568819006975	salt bridge; other site
568819006976	sequence-specific DNA binding site [nucleotide binding]; other site
568819006977	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
568819006978	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
568819006979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819006980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819006981	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
568819006982	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
568819006983	substrate binding pocket [chemical binding]; other site
568819006984	argininosuccinate synthase; Provisional; Region: PRK13820
568819006985	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
568819006986	ANP binding site [chemical binding]; other site
568819006987	Substrate Binding Site II [chemical binding]; other site
568819006988	Substrate Binding Site I [chemical binding]; other site
568819006989	argininosuccinate lyase; Provisional; Region: PRK00855
568819006990	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
568819006991	active sites [active]
568819006992	tetramer interface [polypeptide binding]; other site
568819006993	BCCT family transporter; Region: BCCT; pfam02028
568819006994	hypothetical protein; Provisional; Region: PRK06357
568819006995	active site
568819006996	intersubunit interface [polypeptide binding]; other site
568819006997	Zn2+ binding site [ion binding]; other site
568819006998	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
568819006999	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
568819007000	putative substrate binding site [chemical binding]; other site
568819007001	putative ATP binding site [chemical binding]; other site
568819007002	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
568819007003	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819007004	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819007005	active site
568819007006	P-loop; other site
568819007007	phosphorylation site [posttranslational modification]
568819007008	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007009	active site
568819007010	phosphorylation site [posttranslational modification]
568819007011	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819007012	PRD domain; Region: PRD; pfam00874
568819007013	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819007014	active site
568819007015	P-loop; other site
568819007016	phosphorylation site [posttranslational modification]
568819007017	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
568819007018	active site
568819007019	phosphorylation site [posttranslational modification]
568819007020	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
568819007021	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819007022	DNA-binding site [nucleotide binding]; DNA binding site
568819007023	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819007024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007025	homodimer interface [polypeptide binding]; other site
568819007026	catalytic residue [active]
568819007027	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
568819007028	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
568819007029	active site
568819007030	multimer interface [polypeptide binding]; other site
568819007031	glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525
568819007032	conserved cys residue [active]
568819007033	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
568819007034	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
568819007035	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
568819007036	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
568819007037	G1 box; other site
568819007038	GTP/Mg2+ binding site [chemical binding]; other site
568819007039	Switch I region; other site
568819007040	G2 box; other site
568819007041	G3 box; other site
568819007042	Switch II region; other site
568819007043	G4 box; other site
568819007044	G5 box; other site
568819007045	Nucleoside recognition; Region: Gate; pfam07670
568819007046	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
568819007047	Nucleoside recognition; Region: Gate; pfam07670
568819007048	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
568819007049	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
568819007050	putative active site [active]
568819007051	putative metal binding site [ion binding]; other site
568819007052	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819007053	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568819007054	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819007055	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
568819007056	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
568819007057	active site
568819007058	dimer interface [polypeptide binding]; other site
568819007059	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568819007060	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
568819007061	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
568819007062	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
568819007063	dimer interface [polypeptide binding]; other site
568819007064	FMN binding site [chemical binding]; other site
568819007065	NADPH bind site [chemical binding]; other site
568819007066	Helix-turn-helix domain; Region: HTH_17; pfam12728
568819007067	putative heme peroxidase; Provisional; Region: PRK12276
568819007068	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819007069	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819007070	Walker A/P-loop; other site
568819007071	ATP binding site [chemical binding]; other site
568819007072	Q-loop/lid; other site
568819007073	ABC transporter signature motif; other site
568819007074	Walker B; other site
568819007075	D-loop; other site
568819007076	H-loop/switch region; other site
568819007077	FtsX-like permease family; Region: FtsX; pfam02687
568819007078	FtsX-like permease family; Region: FtsX; pfam02687
568819007079	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819007080	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819007081	Coenzyme A binding pocket [chemical binding]; other site
568819007082	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
568819007083	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
568819007084	active site
568819007085	substrate binding site [chemical binding]; other site
568819007086	metal binding site [ion binding]; metal-binding site
568819007087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
568819007088	YbbR-like protein; Region: YbbR; pfam07949
568819007089	YbbR-like protein; Region: YbbR; pfam07949
568819007090	YbbR-like protein; Region: YbbR; pfam07949
568819007091	Uncharacterized conserved protein [Function unknown]; Region: COG1624
568819007092	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
568819007093	maltose phosphorylase; Provisional; Region: PRK13807
568819007094	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
568819007095	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
568819007096	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
568819007097	Predicted integral membrane protein [Function unknown]; Region: COG5521
568819007098	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819007099	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007100	dimer interface [polypeptide binding]; other site
568819007101	conserved gate region; other site
568819007102	putative PBP binding loops; other site
568819007103	ABC-ATPase subunit interface; other site
568819007104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007105	dimer interface [polypeptide binding]; other site
568819007106	conserved gate region; other site
568819007107	putative PBP binding loops; other site
568819007108	ABC-ATPase subunit interface; other site
568819007109	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
568819007110	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819007111	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
568819007112	homodimer interface [polypeptide binding]; other site
568819007113	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
568819007114	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
568819007115	active site
568819007116	homodimer interface [polypeptide binding]; other site
568819007117	catalytic site [active]
568819007118	CAAX protease self-immunity; Region: Abi; cl00558
568819007119	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819007120	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819007121	DNA binding site [nucleotide binding]
568819007122	domain linker motif; other site
568819007123	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
568819007124	ligand binding site [chemical binding]; other site
568819007125	dimerization interface [polypeptide binding]; other site
568819007126	Amino acid permease; Region: AA_permease_2; pfam13520
568819007127	K+ potassium transporter; Region: K_trans; cl15781
568819007128	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007129	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819007130	ligand binding site [chemical binding]; other site
568819007131	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007132	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819007133	ligand binding site [chemical binding]; other site
568819007134	flexible hinge region; other site
568819007135	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819007136	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568819007137	intersubunit interface [polypeptide binding]; other site
568819007138	active site
568819007139	zinc binding site [ion binding]; other site
568819007140	Na+ binding site [ion binding]; other site
568819007141	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568819007142	intersubunit interface [polypeptide binding]; other site
568819007143	active site
568819007144	zinc binding site [ion binding]; other site
568819007145	Na+ binding site [ion binding]; other site
568819007146	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819007147	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819007148	active site
568819007149	P-loop; other site
568819007150	phosphorylation site [posttranslational modification]
568819007151	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007152	active site
568819007153	phosphorylation site [posttranslational modification]
568819007154	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819007155	HTH domain; Region: HTH_11; pfam08279
568819007156	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819007157	PRD domain; Region: PRD; pfam00874
568819007158	PRD domain; Region: PRD; pfam00874
568819007159	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819007160	active site
568819007161	P-loop; other site
568819007162	phosphorylation site [posttranslational modification]
568819007163	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
568819007164	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819007165	Walker A/P-loop; other site
568819007166	ATP binding site [chemical binding]; other site
568819007167	Q-loop/lid; other site
568819007168	ABC transporter signature motif; other site
568819007169	Walker B; other site
568819007170	D-loop; other site
568819007171	H-loop/switch region; other site
568819007172	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
568819007173	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
568819007174	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
568819007175	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819007176	Coenzyme A binding pocket [chemical binding]; other site
568819007177	Transcriptional regulators [Transcription]; Region: GntR; COG1802
568819007178	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
568819007179	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
568819007180	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
568819007181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819007182	DNA-binding site [nucleotide binding]; DNA binding site
568819007183	UTRA domain; Region: UTRA; pfam07702
568819007184	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
568819007185	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
568819007186	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819007187	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819007188	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
568819007189	putative dimerization interface [polypeptide binding]; other site
568819007190	Predicted membrane protein [Function unknown]; Region: COG2855
568819007191	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
568819007192	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
568819007193	putative metal binding site [ion binding]; other site
568819007194	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
568819007195	homodimer interface [polypeptide binding]; other site
568819007196	chemical substrate binding site [chemical binding]; other site
568819007197	oligomer interface [polypeptide binding]; other site
568819007198	metal binding site [ion binding]; metal-binding site
568819007199	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819007200	catalytic residues [active]
568819007201	flavodoxin; Provisional; Region: PRK09271
568819007202	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
568819007203	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
568819007204	dimer interface [polypeptide binding]; other site
568819007205	putative radical transfer pathway; other site
568819007206	diiron center [ion binding]; other site
568819007207	tyrosyl radical; other site
568819007208	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
568819007209	Class I ribonucleotide reductase; Region: RNR_I; cd01679
568819007210	active site
568819007211	dimer interface [polypeptide binding]; other site
568819007212	catalytic residues [active]
568819007213	effector binding site; other site
568819007214	R2 peptide binding site; other site
568819007215	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
568819007216	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
568819007217	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
568819007218	SCP-2 sterol transfer family; Region: SCP2; cl01225
568819007219	CsbD-like; Region: CsbD; cl17424
568819007220	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819007221	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819007222	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568819007223	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568819007224	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
568819007225	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
568819007226	conserved cys residue [active]
568819007227	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568819007228	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819007229	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819007230	Cupin; Region: Cupin_1; pfam00190
568819007231	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819007232	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819007233	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007234	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007235	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819007236	ligand binding site [chemical binding]; other site
568819007237	flexible hinge region; other site
568819007238	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
568819007239	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
568819007240	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819007241	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
568819007242	dimer interface [polypeptide binding]; other site
568819007243	active site
568819007244	metal binding site [ion binding]; metal-binding site
568819007245	glutathione binding site [chemical binding]; other site
568819007246	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
568819007247	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
568819007248	FMN binding site [chemical binding]; other site
568819007249	substrate binding site [chemical binding]; other site
568819007250	putative catalytic residue [active]
568819007251	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
568819007252	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
568819007253	Coenzyme A transferase; Region: CoA_trans; smart00882
568819007254	Coenzyme A transferase; Region: CoA_trans; cl17247
568819007255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819007256	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
568819007257	Walker A motif; other site
568819007258	ATP binding site [chemical binding]; other site
568819007259	Walker B motif; other site
568819007260	arginine finger; other site
568819007261	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
568819007262	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
568819007263	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
568819007264	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
568819007265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
568819007266	metal binding site [ion binding]; metal-binding site
568819007267	active site
568819007268	I-site; other site
568819007269	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
568819007270	classical (c) SDRs; Region: SDR_c; cd05233
568819007271	NAD(P) binding site [chemical binding]; other site
568819007272	active site
568819007273	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
568819007274	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819007275	Tic20-like protein; Region: Tic20; pfam09685
568819007276	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819007277	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007278	Collagen binding domain; Region: Collagen_bind; pfam05737
568819007279	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007280	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007281	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007282	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007283	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
568819007284	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007285	Collagen binding domain; Region: Collagen_bind; pfam05737
568819007286	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007287	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007288	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007289	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007290	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007291	Cna protein B-type domain; Region: Cna_B; pfam05738
568819007292	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007293	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819007294	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007295	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007296	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819007297	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
568819007298	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
568819007299	active site
568819007300	catalytic site [active]
568819007301	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819007302	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819007303	Walker A/P-loop; other site
568819007304	ATP binding site [chemical binding]; other site
568819007305	Q-loop/lid; other site
568819007306	ABC transporter signature motif; other site
568819007307	Walker B; other site
568819007308	D-loop; other site
568819007309	H-loop/switch region; other site
568819007310	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
568819007311	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819007312	ABC-ATPase subunit  interface; other site
568819007313	dimer interface [polypeptide binding]; other site
568819007314	putative PBP binding regions; other site
568819007315	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
568819007316	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568819007317	intersubunit interface [polypeptide binding]; other site
568819007318	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819007319	heme-binding site [chemical binding]; other site
568819007320	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
568819007321	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819007322	heme-binding site [chemical binding]; other site
568819007323	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819007324	heme-binding site [chemical binding]; other site
568819007325	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
568819007326	heme uptake protein IsdC; Region: IsdC; TIGR03656
568819007327	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
568819007328	heme-binding site [chemical binding]; other site
568819007329	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
568819007330	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
568819007331	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
568819007332	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
568819007333	active site
568819007334	Zn binding site [ion binding]; other site
568819007335	Competence protein CoiA-like family; Region: CoiA; cl11541
568819007336	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
568819007337	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
568819007338	ArsC family; Region: ArsC; pfam03960
568819007339	putative catalytic residues [active]
568819007340	thiol/disulfide switch; other site
568819007341	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
568819007342	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568819007343	Walker A/P-loop; other site
568819007344	ATP binding site [chemical binding]; other site
568819007345	Q-loop/lid; other site
568819007346	ABC transporter signature motif; other site
568819007347	Walker B; other site
568819007348	D-loop; other site
568819007349	H-loop/switch region; other site
568819007350	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568819007351	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
568819007352	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
568819007353	Walker A/P-loop; other site
568819007354	ATP binding site [chemical binding]; other site
568819007355	Q-loop/lid; other site
568819007356	ABC transporter signature motif; other site
568819007357	Walker B; other site
568819007358	D-loop; other site
568819007359	H-loop/switch region; other site
568819007360	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
568819007361	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
568819007362	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007363	dimer interface [polypeptide binding]; other site
568819007364	conserved gate region; other site
568819007365	putative PBP binding loops; other site
568819007366	ABC-ATPase subunit interface; other site
568819007367	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
568819007368	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007369	dimer interface [polypeptide binding]; other site
568819007370	conserved gate region; other site
568819007371	putative PBP binding loops; other site
568819007372	ABC-ATPase subunit interface; other site
568819007373	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819007374	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819007375	peptide binding site [polypeptide binding]; other site
568819007376	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
568819007377	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
568819007378	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
568819007379	active site
568819007380	HIGH motif; other site
568819007381	dimer interface [polypeptide binding]; other site
568819007382	KMSKS motif; other site
568819007383	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
568819007384	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819007385	MarR family; Region: MarR; pfam01047
568819007386	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
568819007387	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
568819007388	dimer interface [polypeptide binding]; other site
568819007389	active site
568819007390	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
568819007391	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
568819007392	dimer interface [polypeptide binding]; other site
568819007393	active site
568819007394	CoA binding pocket [chemical binding]; other site
568819007395	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819007396	SH3-like domain; Region: SH3_8; pfam13457
568819007397	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
568819007398	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819007399	catalytic core [active]
568819007400	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
568819007401	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
568819007402	Clp amino terminal domain; Region: Clp_N; pfam02861
568819007403	Clp amino terminal domain; Region: Clp_N; pfam02861
568819007404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819007405	Walker A motif; other site
568819007406	ATP binding site [chemical binding]; other site
568819007407	Walker B motif; other site
568819007408	arginine finger; other site
568819007409	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819007410	Walker A motif; other site
568819007411	ATP binding site [chemical binding]; other site
568819007412	Walker B motif; other site
568819007413	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
568819007414	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
568819007415	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
568819007416	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819007417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819007418	active site
568819007419	motif I; other site
568819007420	motif II; other site
568819007421	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568819007422	Predicted acetyltransferase [General function prediction only]; Region: COG3393
568819007423	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
568819007424	ferrochelatase; Provisional; Region: PRK12435
568819007425	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
568819007426	C-terminal domain interface [polypeptide binding]; other site
568819007427	active site
568819007428	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
568819007429	active site
568819007430	N-terminal domain interface [polypeptide binding]; other site
568819007431	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
568819007432	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
568819007433	substrate binding site [chemical binding]; other site
568819007434	active site
568819007435	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
568819007436	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
568819007437	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568819007438	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819007439	Walker A/P-loop; other site
568819007440	ATP binding site [chemical binding]; other site
568819007441	Q-loop/lid; other site
568819007442	ABC transporter signature motif; other site
568819007443	Walker B; other site
568819007444	D-loop; other site
568819007445	H-loop/switch region; other site
568819007446	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
568819007447	HIT family signature motif; other site
568819007448	catalytic residue [active]
568819007449	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
568819007450	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
568819007451	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
568819007452	SurA N-terminal domain; Region: SurA_N_3; cl07813
568819007453	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
568819007454	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
568819007455	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
568819007456	generic binding surface II; other site
568819007457	generic binding surface I; other site
568819007458	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819007459	Zn2+ binding site [ion binding]; other site
568819007460	Mg2+ binding site [ion binding]; other site
568819007461	Uncharacterized conserved protein [Function unknown]; Region: COG4717
568819007462	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
568819007463	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
568819007464	active site
568819007465	metal binding site [ion binding]; metal-binding site
568819007466	DNA binding site [nucleotide binding]
568819007467	hypothetical protein; Provisional; Region: PRK13676
568819007468	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
568819007469	fumarate hydratase; Reviewed; Region: fumC; PRK00485
568819007470	Class II fumarases; Region: Fumarase_classII; cd01362
568819007471	active site
568819007472	tetramer interface [polypeptide binding]; other site
568819007473	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568819007474	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819007475	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819007476	Walker A/P-loop; other site
568819007477	ATP binding site [chemical binding]; other site
568819007478	Q-loop/lid; other site
568819007479	ABC transporter signature motif; other site
568819007480	Walker B; other site
568819007481	D-loop; other site
568819007482	H-loop/switch region; other site
568819007483	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
568819007484	Transglycosylase; Region: Transgly; pfam00912
568819007485	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
568819007486	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
568819007487	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568819007488	Low molecular weight phosphatase family; Region: LMWPc; cl00105
568819007489	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819007490	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
568819007491	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819007492	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819007493	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819007494	Transporter associated domain; Region: CorC_HlyC; smart01091
568819007495	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819007496	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819007497	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
568819007498	putative dimerization interface [polypeptide binding]; other site
568819007499	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
568819007500	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
568819007501	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
568819007502	active site
568819007503	FMN binding site [chemical binding]; other site
568819007504	substrate binding site [chemical binding]; other site
568819007505	putative catalytic residue [active]
568819007506	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819007507	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819007508	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
568819007509	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
568819007510	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
568819007511	shikimate binding site; other site
568819007512	NAD(P) binding site [chemical binding]; other site
568819007513	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007514	putative substrate translocation pore; other site
568819007515	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819007516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007517	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819007518	putative substrate translocation pore; other site
568819007519	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
568819007520	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819007521	Walker A/P-loop; other site
568819007522	ATP binding site [chemical binding]; other site
568819007523	Q-loop/lid; other site
568819007524	ABC transporter signature motif; other site
568819007525	Walker B; other site
568819007526	D-loop; other site
568819007527	H-loop/switch region; other site
568819007528	Predicted transcriptional regulators [Transcription]; Region: COG1725
568819007529	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
568819007530	DNA-binding site [nucleotide binding]; DNA binding site
568819007531	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
568819007532	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
568819007533	DNA binding site [nucleotide binding]
568819007534	active site
568819007535	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
568819007536	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
568819007537	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819007538	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819007539	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
568819007540	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
568819007541	active site
568819007542	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
568819007543	putative dimer interface [polypeptide binding]; other site
568819007544	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819007545	ligand binding site [chemical binding]; other site
568819007546	Zn binding site [ion binding]; other site
568819007547	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
568819007548	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
568819007549	active site
568819007550	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819007551	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819007552	active site
568819007553	catalytic tetrad [active]
568819007554	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
568819007555	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
568819007556	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568819007557	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819007558	substrate binding pocket [chemical binding]; other site
568819007559	membrane-bound complex binding site; other site
568819007560	hinge residues; other site
568819007561	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819007562	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007563	dimer interface [polypeptide binding]; other site
568819007564	conserved gate region; other site
568819007565	putative PBP binding loops; other site
568819007566	ABC-ATPase subunit interface; other site
568819007567	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819007568	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568819007569	Walker A/P-loop; other site
568819007570	ATP binding site [chemical binding]; other site
568819007571	Q-loop/lid; other site
568819007572	ABC transporter signature motif; other site
568819007573	Walker B; other site
568819007574	D-loop; other site
568819007575	H-loop/switch region; other site
568819007576	aspartate aminotransferase; Provisional; Region: PRK06348
568819007577	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819007578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007579	homodimer interface [polypeptide binding]; other site
568819007580	catalytic residue [active]
568819007581	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
568819007582	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568819007583	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819007584	motif II; other site
568819007585	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
568819007586	intracellular protease, PfpI family; Region: PfpI; TIGR01382
568819007587	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
568819007588	proposed catalytic triad [active]
568819007589	conserved cys residue [active]
568819007590	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
568819007591	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819007592	methionine cluster; other site
568819007593	active site
568819007594	phosphorylation site [posttranslational modification]
568819007595	metal binding site [ion binding]; metal-binding site
568819007596	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819007597	Coenzyme A binding pocket [chemical binding]; other site
568819007598	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819007599	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
568819007600	esterase; Provisional; Region: PRK10566
568819007601	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
568819007602	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819007603	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
568819007604	motif II; other site
568819007605	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819007606	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819007607	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819007608	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819007609	hypothetical protein; Provisional; Region: PRK13673
568819007610	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
568819007611	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
568819007612	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
568819007613	Part of AAA domain; Region: AAA_19; pfam13245
568819007614	Family description; Region: UvrD_C_2; pfam13538
568819007615	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
568819007616	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
568819007617	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
568819007618	IDEAL domain; Region: IDEAL; pfam08858
568819007619	ComK protein; Region: ComK; cl11560
568819007620	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
568819007621	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819007622	non-specific DNA binding site [nucleotide binding]; other site
568819007623	salt bridge; other site
568819007624	sequence-specific DNA binding site [nucleotide binding]; other site
568819007625	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
568819007626	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007627	active site
568819007628	phosphorylation site [posttranslational modification]
568819007629	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819007630	active site
568819007631	P-loop; other site
568819007632	phosphorylation site [posttranslational modification]
568819007633	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819007634	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
568819007635	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
568819007636	putative substrate binding site [chemical binding]; other site
568819007637	putative ATP binding site [chemical binding]; other site
568819007638	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819007639	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568819007640	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819007641	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
568819007642	trimer interface [polypeptide binding]; other site
568819007643	active site
568819007644	G bulge; other site
568819007645	Uncharacterized conserved protein [Function unknown]; Region: COG1683
568819007646	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
568819007647	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
568819007648	non-specific DNA interactions [nucleotide binding]; other site
568819007649	DNA binding site [nucleotide binding]
568819007650	sequence specific DNA binding site [nucleotide binding]; other site
568819007651	putative cAMP binding site [chemical binding]; other site
568819007652	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
568819007653	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
568819007654	substrate binding site [chemical binding]; other site
568819007655	ATP binding site [chemical binding]; other site
568819007656	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
568819007657	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
568819007658	RNA binding surface [nucleotide binding]; other site
568819007659	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
568819007660	active site
568819007661	uracil binding [chemical binding]; other site
568819007662	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
568819007663	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
568819007664	active site
568819007665	non-prolyl cis peptide bond; other site
568819007666	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
568819007667	catalytic residues [active]
568819007668	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
568819007669	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
568819007670	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
568819007671	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
568819007672	Walker A/P-loop; other site
568819007673	ATP binding site [chemical binding]; other site
568819007674	Q-loop/lid; other site
568819007675	ABC transporter signature motif; other site
568819007676	Walker B; other site
568819007677	D-loop; other site
568819007678	H-loop/switch region; other site
568819007679	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819007680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007681	dimer interface [polypeptide binding]; other site
568819007682	conserved gate region; other site
568819007683	putative PBP binding loops; other site
568819007684	ABC-ATPase subunit interface; other site
568819007685	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
568819007686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007687	dimer interface [polypeptide binding]; other site
568819007688	conserved gate region; other site
568819007689	putative PBP binding loops; other site
568819007690	ABC-ATPase subunit interface; other site
568819007691	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
568819007692	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
568819007693	substrate binding pocket [chemical binding]; other site
568819007694	membrane-bound complex binding site; other site
568819007695	hinge residues; other site
568819007696	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819007697	Coenzyme A binding pocket [chemical binding]; other site
568819007698	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
568819007699	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
568819007700	Transcriptional regulator [Transcription]; Region: LysR; COG0583
568819007701	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
568819007702	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
568819007703	dimerization interface [polypeptide binding]; other site
568819007704	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
568819007705	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
568819007706	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
568819007707	active site
568819007708	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007709	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819007710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007711	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
568819007712	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
568819007713	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
568819007714	active site
568819007715	trimer interface [polypeptide binding]; other site
568819007716	allosteric site; other site
568819007717	active site lid [active]
568819007718	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819007719	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819007720	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
568819007721	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
568819007722	Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298
568819007723	NAD binding site [chemical binding]; other site
568819007724	sugar binding site [chemical binding]; other site
568819007725	divalent metal binding site [ion binding]; other site
568819007726	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819007727	dimer interface [polypeptide binding]; other site
568819007728	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819007729	HTH domain; Region: HTH_11; pfam08279
568819007730	PRD domain; Region: PRD; pfam00874
568819007731	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819007732	active site
568819007733	phosphorylation site [posttranslational modification]
568819007734	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
568819007735	putative active site [active]
568819007736	YdjC motif; other site
568819007737	Mg binding site [ion binding]; other site
568819007738	putative homodimer interface [polypeptide binding]; other site
568819007739	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819007740	methionine cluster; other site
568819007741	active site
568819007742	phosphorylation site [posttranslational modification]
568819007743	metal binding site [ion binding]; metal-binding site
568819007744	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819007745	active site
568819007746	P-loop; other site
568819007747	phosphorylation site [posttranslational modification]
568819007748	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819007749	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819007750	Predicted membrane protein [Function unknown]; Region: COG1511
568819007751	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
568819007752	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
568819007753	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
568819007754	Predicted transcriptional regulator [Transcription]; Region: COG1959
568819007755	Transcriptional regulator; Region: Rrf2; pfam02082
568819007756	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
568819007757	L-tyrosine decarboxylase; Provisional; Region: PRK13520
568819007758	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
568819007759	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007760	catalytic residue [active]
568819007761	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
568819007762	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819007763	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
568819007764	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
568819007765	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
568819007766	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
568819007767	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
568819007768	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
568819007769	active site
568819007770	dimer interface [polypeptide binding]; other site
568819007771	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
568819007772	dimer interface [polypeptide binding]; other site
568819007773	active site
568819007774	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
568819007775	nudix motif; other site
568819007776	general stress protein 13; Validated; Region: PRK08059
568819007777	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
568819007778	RNA binding site [nucleotide binding]; other site
568819007779	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
568819007780	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
568819007781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007782	homodimer interface [polypeptide binding]; other site
568819007783	catalytic residue [active]
568819007784	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
568819007785	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819007786	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819007787	Walker A/P-loop; other site
568819007788	ATP binding site [chemical binding]; other site
568819007789	Q-loop/lid; other site
568819007790	ABC transporter signature motif; other site
568819007791	Walker B; other site
568819007792	D-loop; other site
568819007793	H-loop/switch region; other site
568819007794	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819007795	active site
568819007796	P-loop; other site
568819007797	phosphorylation site [posttranslational modification]
568819007798	aspartate kinase; Reviewed; Region: PRK09034
568819007799	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
568819007800	putative catalytic residues [active]
568819007801	putative nucleotide binding site [chemical binding]; other site
568819007802	putative aspartate binding site [chemical binding]; other site
568819007803	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
568819007804	allosteric regulatory residue; other site
568819007805	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
568819007806	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
568819007807	putative active site [active]
568819007808	putative NTP binding site [chemical binding]; other site
568819007809	putative nucleic acid binding site [nucleotide binding]; other site
568819007810	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
568819007811	active site
568819007812	drug efflux system protein MdtG; Provisional; Region: PRK09874
568819007813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819007814	putative substrate translocation pore; other site
568819007815	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
568819007816	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568819007817	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
568819007818	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
568819007819	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
568819007820	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
568819007821	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
568819007822	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
568819007823	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
568819007824	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
568819007825	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
568819007826	CoenzymeA binding site [chemical binding]; other site
568819007827	subunit interaction site [polypeptide binding]; other site
568819007828	PHB binding site; other site
568819007829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
568819007830	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
568819007831	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
568819007832	Cl- selectivity filter; other site
568819007833	Cl- binding residues [ion binding]; other site
568819007834	pore gating glutamate residue; other site
568819007835	dimer interface [polypeptide binding]; other site
568819007836	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819007837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
568819007838	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568819007839	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819007840	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
568819007841	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819007842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819007843	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
568819007844	NADH(P)-binding; Region: NAD_binding_10; pfam13460
568819007845	NAD(P) binding site [chemical binding]; other site
568819007846	putative active site [active]
568819007847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
568819007848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
568819007849	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819007850	Leucine-rich repeats; other site
568819007851	Substrate binding site [chemical binding]; other site
568819007852	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007853	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007854	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819007855	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007856	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007857	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007858	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007859	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007860	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819007861	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
568819007862	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
568819007863	tetramer interfaces [polypeptide binding]; other site
568819007864	binuclear metal-binding site [ion binding]; other site
568819007865	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819007866	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819007867	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819007868	Transporter associated domain; Region: CorC_HlyC; smart01091
568819007869	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
568819007870	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819007871	Coenzyme A binding pocket [chemical binding]; other site
568819007872	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
568819007873	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819007874	active site
568819007875	motif I; other site
568819007876	motif II; other site
568819007877	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819007878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
568819007879	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
568819007880	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
568819007881	active site
568819007882	metal binding site [ion binding]; metal-binding site
568819007883	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
568819007884	Predicted permeases [General function prediction only]; Region: COG0730
568819007885	Predicted membrane protein [Function unknown]; Region: COG4272
568819007886	Uncharacterized conserved protein [Function unknown]; Region: COG1801
568819007887	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
568819007888	FeS assembly protein SufB; Region: sufB; TIGR01980
568819007889	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
568819007890	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
568819007891	trimerization site [polypeptide binding]; other site
568819007892	active site
568819007893	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
568819007894	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
568819007895	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819007896	catalytic residue [active]
568819007897	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
568819007898	FeS assembly protein SufD; Region: sufD; TIGR01981
568819007899	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
568819007900	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
568819007901	Walker A/P-loop; other site
568819007902	ATP binding site [chemical binding]; other site
568819007903	Q-loop/lid; other site
568819007904	ABC transporter signature motif; other site
568819007905	Walker B; other site
568819007906	D-loop; other site
568819007907	H-loop/switch region; other site
568819007908	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
568819007909	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
568819007910	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819007911	ABC-ATPase subunit interface; other site
568819007912	putative PBP binding loops; other site
568819007913	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
568819007914	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
568819007915	Walker A/P-loop; other site
568819007916	ATP binding site [chemical binding]; other site
568819007917	Q-loop/lid; other site
568819007918	ABC transporter signature motif; other site
568819007919	Walker B; other site
568819007920	D-loop; other site
568819007921	H-loop/switch region; other site
568819007922	NIL domain; Region: NIL; pfam09383
568819007923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819007924	dimer interface [polypeptide binding]; other site
568819007925	phosphorylation site [posttranslational modification]
568819007926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819007927	ATP binding site [chemical binding]; other site
568819007928	Mg2+ binding site [ion binding]; other site
568819007929	G-X-G motif; other site
568819007930	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819007931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819007932	active site
568819007933	phosphorylation site [posttranslational modification]
568819007934	intermolecular recognition site; other site
568819007935	dimerization interface [polypeptide binding]; other site
568819007936	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819007937	DNA binding site [nucleotide binding]
568819007938	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819007939	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
568819007940	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819007941	catalytic residues [active]
568819007942	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
568819007943	lipoyl attachment site [posttranslational modification]; other site
568819007944	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
568819007945	ArsC family; Region: ArsC; pfam03960
568819007946	putative ArsC-like catalytic residues; other site
568819007947	putative TRX-like catalytic residues [active]
568819007948	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
568819007949	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
568819007950	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
568819007951	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
568819007952	Walker A/P-loop; other site
568819007953	ATP binding site [chemical binding]; other site
568819007954	Q-loop/lid; other site
568819007955	ABC transporter signature motif; other site
568819007956	Walker B; other site
568819007957	D-loop; other site
568819007958	H-loop/switch region; other site
568819007959	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
568819007960	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
568819007961	ABC-ATPase subunit  interface; other site
568819007962	dimer interface [polypeptide binding]; other site
568819007963	putative PBP binding regions; other site
568819007964	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
568819007965	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
568819007966	intersubunit interface [polypeptide binding]; other site
568819007967	Predicted esterase [General function prediction only]; Region: COG0627
568819007968	S-formylglutathione hydrolase; Region: PLN02442
568819007969	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
568819007970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819007971	catalytic residue [active]
568819007972	SdpI/YhfL protein family; Region: SdpI; pfam13630
568819007973	CAT RNA binding domain; Region: CAT_RBD; smart01061
568819007974	transcriptional antiterminator BglG; Provisional; Region: PRK09772
568819007975	PRD domain; Region: PRD; pfam00874
568819007976	PRD domain; Region: PRD; pfam00874
568819007977	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
568819007978	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
568819007979	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
568819007980	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
568819007981	Predicted transcriptional regulator [Transcription]; Region: COG2378
568819007982	HTH domain; Region: HTH_11; pfam08279
568819007983	WYL domain; Region: WYL; pfam13280
568819007984	Uncharacterized conserved protein [Function unknown]; Region: COG1434
568819007985	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
568819007986	putative active site [active]
568819007987	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819007988	Leucine rich repeat; Region: LRR_8; pfam13855
568819007989	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819007990	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
568819007991	active site
568819007992	catalytic site [active]
568819007993	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819007994	putative metal binding site [ion binding]; other site
568819007995	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819007996	putative metal binding site [ion binding]; other site
568819007997	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819007998	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
568819007999	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
568819008000	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
568819008001	active site
568819008002	catalytic site [active]
568819008003	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
568819008004	putative metal binding site [ion binding]; other site
568819008005	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819008006	non-specific DNA binding site [nucleotide binding]; other site
568819008007	salt bridge; other site
568819008008	sequence-specific DNA binding site [nucleotide binding]; other site
568819008009	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
568819008010	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
568819008011	SmpB-tmRNA interface; other site
568819008012	ribonuclease R; Region: RNase_R; TIGR02063
568819008013	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
568819008014	RNB domain; Region: RNB; pfam00773
568819008015	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
568819008016	RNA binding site [nucleotide binding]; other site
568819008017	Esterase/lipase [General function prediction only]; Region: COG1647
568819008018	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819008019	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
568819008020	Preprotein translocase SecG subunit; Region: SecG; cl09123
568819008021	Esterase/lipase [General function prediction only]; Region: COG1647
568819008022	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
568819008023	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
568819008024	PGAP1-like protein; Region: PGAP1; pfam07819
568819008025	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
568819008026	enolase; Provisional; Region: eno; PRK00077
568819008027	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
568819008028	dimer interface [polypeptide binding]; other site
568819008029	metal binding site [ion binding]; metal-binding site
568819008030	substrate binding pocket [chemical binding]; other site
568819008031	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
568819008032	phosphoglyceromutase; Provisional; Region: PRK05434
568819008033	triosephosphate isomerase; Provisional; Region: PRK14567
568819008034	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
568819008035	substrate binding site [chemical binding]; other site
568819008036	dimer interface [polypeptide binding]; other site
568819008037	catalytic triad [active]
568819008038	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
568819008039	Phosphoglycerate kinase; Region: PGK; pfam00162
568819008040	substrate binding site [chemical binding]; other site
568819008041	hinge regions; other site
568819008042	ADP binding site [chemical binding]; other site
568819008043	catalytic site [active]
568819008044	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
568819008045	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
568819008046	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
568819008047	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
568819008048	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
568819008049	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
568819008050	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
568819008051	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
568819008052	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819008053	DNA binding site [nucleotide binding]
568819008054	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
568819008055	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
568819008056	active site
568819008057	dimer interface [polypeptide binding]; other site
568819008058	MMPL family; Region: MMPL; pfam03176
568819008059	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
568819008060	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819008061	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819008062	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
568819008063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
568819008064	Chitin binding domain; Region: Chitin_bind_3; pfam03067
568819008065	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568819008066	Interdomain contacts; other site
568819008067	Cytokine receptor motif; other site
568819008068	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
568819008069	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
568819008070	Interdomain contacts; other site
568819008071	Cytokine receptor motif; other site
568819008072	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
568819008073	aromatic chitin/cellulose binding site residues [chemical binding]; other site
568819008074	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
568819008075	aromatic chitin/cellulose binding site residues [chemical binding]; other site
568819008076	Clp protease; Region: CLP_protease; pfam00574
568819008077	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
568819008078	oligomer interface [polypeptide binding]; other site
568819008079	active site residues [active]
568819008080	amino acid transporter; Region: 2A0306; TIGR00909
568819008081	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
568819008082	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
568819008083	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819008084	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819008085	Substrate binding site [chemical binding]; other site
568819008086	Leucine rich repeat; Region: LRR_8; pfam13855
568819008087	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819008088	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
568819008089	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
568819008090	active site
568819008091	FMN binding site [chemical binding]; other site
568819008092	substrate binding site [chemical binding]; other site
568819008093	homotetramer interface [polypeptide binding]; other site
568819008094	catalytic residue [active]
568819008095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
568819008096	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
568819008097	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
568819008098	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
568819008099	phosphate binding site [ion binding]; other site
568819008100	putative substrate binding pocket [chemical binding]; other site
568819008101	dimer interface [polypeptide binding]; other site
568819008102	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
568819008103	AAA domain; Region: AAA_18; pfam13238
568819008104	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
568819008105	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
568819008106	active site
568819008107	substrate binding site [chemical binding]; other site
568819008108	metal binding site [ion binding]; metal-binding site
568819008109	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
568819008110	active site
568819008111	catalytic residues [active]
568819008112	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
568819008113	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
568819008114	NAD binding site [chemical binding]; other site
568819008115	homodimer interface [polypeptide binding]; other site
568819008116	active site
568819008117	substrate binding site [chemical binding]; other site
568819008118	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
568819008119	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
568819008120	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819008121	TPR repeat; Region: TPR_11; pfam13414
568819008122	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819008123	binding surface
568819008124	TPR motif; other site
568819008125	Tetratricopeptide repeat; Region: TPR_12; pfam13424
568819008126	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
568819008127	binding surface
568819008128	TPR motif; other site
568819008129	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
568819008130	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
568819008131	putative trimer interface [polypeptide binding]; other site
568819008132	putative CoA binding site [chemical binding]; other site
568819008133	pyrophosphatase PpaX; Provisional; Region: PRK13288
568819008134	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819008135	motif II; other site
568819008136	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
568819008137	HPr kinase/phosphorylase; Provisional; Region: PRK05428
568819008138	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
568819008139	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
568819008140	Hpr binding site; other site
568819008141	active site
568819008142	homohexamer subunit interaction site [polypeptide binding]; other site
568819008143	Predicted membrane protein [Function unknown]; Region: COG1950
568819008144	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
568819008145	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
568819008146	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819008147	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568819008148	Uncharacterized conserved protein [Function unknown]; Region: COG3595
568819008149	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
568819008150	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
568819008151	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568819008152	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
568819008153	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
568819008154	excinuclease ABC subunit B; Provisional; Region: PRK05298
568819008155	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819008156	ATP binding site [chemical binding]; other site
568819008157	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819008158	nucleotide binding region [chemical binding]; other site
568819008159	ATP-binding site [chemical binding]; other site
568819008160	Ultra-violet resistance protein B; Region: UvrB; pfam12344
568819008161	UvrB/uvrC motif; Region: UVR; pfam02151
568819008162	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
568819008163	HD containing hydrolase-like enzyme; Region: HD_2; pfam12917
568819008164	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
568819008165	dimerization interface [polypeptide binding]; other site
568819008166	putative DNA binding site [nucleotide binding]; other site
568819008167	putative Zn2+ binding site [ion binding]; other site
568819008168	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
568819008169	PhoU domain; Region: PhoU; pfam01895
568819008170	PhoU domain; Region: PhoU; pfam01895
568819008171	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
568819008172	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
568819008173	Walker A/P-loop; other site
568819008174	ATP binding site [chemical binding]; other site
568819008175	Q-loop/lid; other site
568819008176	ABC transporter signature motif; other site
568819008177	Walker B; other site
568819008178	D-loop; other site
568819008179	H-loop/switch region; other site
568819008180	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
568819008181	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
568819008182	Walker A/P-loop; other site
568819008183	ATP binding site [chemical binding]; other site
568819008184	Q-loop/lid; other site
568819008185	ABC transporter signature motif; other site
568819008186	Walker B; other site
568819008187	D-loop; other site
568819008188	H-loop/switch region; other site
568819008189	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
568819008190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819008191	dimer interface [polypeptide binding]; other site
568819008192	conserved gate region; other site
568819008193	putative PBP binding loops; other site
568819008194	ABC-ATPase subunit interface; other site
568819008195	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
568819008196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819008197	dimer interface [polypeptide binding]; other site
568819008198	conserved gate region; other site
568819008199	putative PBP binding loops; other site
568819008200	ABC-ATPase subunit interface; other site
568819008201	PBP superfamily domain; Region: PBP_like_2; cl17296
568819008202	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
568819008203	HAMP domain; Region: HAMP; pfam00672
568819008204	dimerization interface [polypeptide binding]; other site
568819008205	PAS domain; Region: PAS; smart00091
568819008206	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
568819008207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819008208	dimer interface [polypeptide binding]; other site
568819008209	phosphorylation site [posttranslational modification]
568819008210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819008211	ATP binding site [chemical binding]; other site
568819008212	Mg2+ binding site [ion binding]; other site
568819008213	G-X-G motif; other site
568819008214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819008215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819008216	active site
568819008217	phosphorylation site [posttranslational modification]
568819008218	intermolecular recognition site; other site
568819008219	dimerization interface [polypeptide binding]; other site
568819008220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819008221	DNA binding site [nucleotide binding]
568819008222	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
568819008223	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
568819008224	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
568819008225	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
568819008226	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
568819008227	putative active site [active]
568819008228	catalytic site [active]
568819008229	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
568819008230	putative active site [active]
568819008231	catalytic site [active]
568819008232	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568819008233	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
568819008234	Peptidase family M23; Region: Peptidase_M23; pfam01551
568819008235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
568819008236	NlpC/P60 family; Region: NLPC_P60; pfam00877
568819008237	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
568819008238	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
568819008239	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
568819008240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819008241	Walker A/P-loop; other site
568819008242	ATP binding site [chemical binding]; other site
568819008243	Q-loop/lid; other site
568819008244	ABC transporter signature motif; other site
568819008245	Walker B; other site
568819008246	D-loop; other site
568819008247	H-loop/switch region; other site
568819008248	Uncharacterized conserved protein [Function unknown]; Region: COG1284
568819008249	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819008250	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
568819008251	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
568819008252	peptide chain release factor 2; Validated; Region: prfB; PRK00578
568819008253	This domain is found in peptide chain release factors; Region: PCRF; smart00937
568819008254	RF-1 domain; Region: RF-1; pfam00472
568819008255	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
568819008256	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
568819008257	nucleotide binding region [chemical binding]; other site
568819008258	helicase superfamily c-terminal domain; Region: HELICc; smart00490
568819008259	ATP-binding site [chemical binding]; other site
568819008260	SEC-C motif; Region: SEC-C; pfam02810
568819008261	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
568819008262	30S subunit binding site; other site
568819008263	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
568819008264	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819008265	active site
568819008266	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
568819008267	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819008268	ATP binding site [chemical binding]; other site
568819008269	putative Mg++ binding site [ion binding]; other site
568819008270	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819008271	nucleotide binding region [chemical binding]; other site
568819008272	ATP-binding site [chemical binding]; other site
568819008273	EDD domain protein, DegV family; Region: DegV; TIGR00762
568819008274	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
568819008275	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
568819008276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819008277	active site
568819008278	phosphorylation site [posttranslational modification]
568819008279	intermolecular recognition site; other site
568819008280	dimerization interface [polypeptide binding]; other site
568819008281	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
568819008282	DNA binding residues [nucleotide binding]
568819008283	dimerization interface [polypeptide binding]; other site
568819008284	Uncharacterized conserved protein [Function unknown]; Region: COG1739
568819008285	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
568819008286	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
568819008287	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
568819008288	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
568819008289	Transcriptional regulator [Transcription]; Region: LytR; COG1316
568819008290	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
568819008291	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
568819008292	Mg++ binding site [ion binding]; other site
568819008293	putative catalytic motif [active]
568819008294	substrate binding site [chemical binding]; other site
568819008295	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
568819008296	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
568819008297	active site
568819008298	octamer interface [polypeptide binding]; other site
568819008299	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
568819008300	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
568819008301	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008302	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008303	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
568819008304	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
568819008305	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
568819008306	dimer interface [polypeptide binding]; other site
568819008307	ssDNA binding site [nucleotide binding]; other site
568819008308	tetramer (dimer of dimers) interface [polypeptide binding]; other site
568819008309	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
568819008310	rod shape-determining protein Mbl; Provisional; Region: PRK13928
568819008311	MreB and similar proteins; Region: MreB_like; cd10225
568819008312	nucleotide binding site [chemical binding]; other site
568819008313	Mg binding site [ion binding]; other site
568819008314	putative protofilament interaction site [polypeptide binding]; other site
568819008315	RodZ interaction site [polypeptide binding]; other site
568819008316	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
568819008317	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568819008318	hinge; other site
568819008319	active site
568819008320	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
568819008321	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
568819008322	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
568819008323	gamma subunit interface [polypeptide binding]; other site
568819008324	epsilon subunit interface [polypeptide binding]; other site
568819008325	LBP interface [polypeptide binding]; other site
568819008326	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
568819008327	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
568819008328	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
568819008329	alpha subunit interaction interface [polypeptide binding]; other site
568819008330	Walker A motif; other site
568819008331	ATP binding site [chemical binding]; other site
568819008332	Walker B motif; other site
568819008333	inhibitor binding site; inhibition site
568819008334	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819008335	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
568819008336	core domain interface [polypeptide binding]; other site
568819008337	delta subunit interface [polypeptide binding]; other site
568819008338	epsilon subunit interface [polypeptide binding]; other site
568819008339	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
568819008340	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
568819008341	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
568819008342	beta subunit interaction interface [polypeptide binding]; other site
568819008343	Walker A motif; other site
568819008344	ATP binding site [chemical binding]; other site
568819008345	Walker B motif; other site
568819008346	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
568819008347	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
568819008348	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
568819008349	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
568819008350	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
568819008351	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
568819008352	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
568819008353	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
568819008354	ATP synthase I chain; Region: ATP_synt_I; pfam03899
568819008355	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
568819008356	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
568819008357	active site
568819008358	homodimer interface [polypeptide binding]; other site
568819008359	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
568819008360	active site
568819008361	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
568819008362	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
568819008363	dimer interface [polypeptide binding]; other site
568819008364	active site
568819008365	glycine-pyridoxal phosphate binding site [chemical binding]; other site
568819008366	folate binding site [chemical binding]; other site
568819008367	Low molecular weight phosphatase family; Region: LMWPc; cd00115
568819008368	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
568819008369	active site
568819008370	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
568819008371	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
568819008372	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
568819008373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819008374	S-adenosylmethionine binding site [chemical binding]; other site
568819008375	peptide chain release factor 1; Validated; Region: prfA; PRK00591
568819008376	This domain is found in peptide chain release factors; Region: PCRF; smart00937
568819008377	RF-1 domain; Region: RF-1; pfam00472
568819008378	thymidine kinase; Provisional; Region: PRK04296
568819008379	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
568819008380	ATP binding site [chemical binding]; other site
568819008381	Walker A motif; other site
568819008382	Walker B motif; other site
568819008383	homoserine kinase; Provisional; Region: PRK01212
568819008384	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
568819008385	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
568819008386	threonine synthase; Reviewed; Region: PRK06721
568819008387	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
568819008388	homodimer interface [polypeptide binding]; other site
568819008389	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819008390	catalytic residue [active]
568819008391	homoserine dehydrogenase; Provisional; Region: PRK06349
568819008392	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
568819008393	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
568819008394	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
568819008395	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
568819008396	Predicted membrane protein [Function unknown]; Region: COG2246
568819008397	GtrA-like protein; Region: GtrA; pfam04138
568819008398	transcription termination factor Rho; Provisional; Region: rho; PRK09376
568819008399	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
568819008400	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
568819008401	RNA binding site [nucleotide binding]; other site
568819008402	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
568819008403	multimer interface [polypeptide binding]; other site
568819008404	Walker A motif; other site
568819008405	ATP binding site [chemical binding]; other site
568819008406	Walker B motif; other site
568819008407	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
568819008408	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
568819008409	hinge; other site
568819008410	active site
568819008411	Predicted integral membrane protein [Function unknown]; Region: COG0392
568819008412	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568819008413	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
568819008414	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
568819008415	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
568819008416	putative ADP-binding pocket [chemical binding]; other site
568819008417	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
568819008418	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
568819008419	intersubunit interface [polypeptide binding]; other site
568819008420	active site
568819008421	zinc binding site [ion binding]; other site
568819008422	Na+ binding site [ion binding]; other site
568819008423	putative lipid kinase; Reviewed; Region: PRK13055
568819008424	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
568819008425	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
568819008426	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
568819008427	substrate binding site [chemical binding]; other site
568819008428	SH3-like domain; Region: SH3_8; pfam13457
568819008429	SH3-like domain; Region: SH3_8; pfam13457
568819008430	SH3-like domain; Region: SH3_8; pfam13457
568819008431	CTP synthetase; Validated; Region: pyrG; PRK05380
568819008432	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
568819008433	Catalytic site [active]
568819008434	active site
568819008435	UTP binding site [chemical binding]; other site
568819008436	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
568819008437	active site
568819008438	putative oxyanion hole; other site
568819008439	catalytic triad [active]
568819008440	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
568819008441	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
568819008442	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
568819008443	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
568819008444	active site
568819008445	HIGH motif; other site
568819008446	KMSK motif region; other site
568819008447	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
568819008448	tRNA binding surface [nucleotide binding]; other site
568819008449	anticodon binding site; other site
568819008450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
568819008451	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
568819008452	Peptidase family M50; Region: Peptidase_M50; pfam02163
568819008453	active site
568819008454	putative substrate binding region [chemical binding]; other site
568819008455	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
568819008456	active site 1 [active]
568819008457	dimer interface [polypeptide binding]; other site
568819008458	hexamer interface [polypeptide binding]; other site
568819008459	active site 2 [active]
568819008460	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
568819008461	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819008462	Zn2+ binding site [ion binding]; other site
568819008463	Mg2+ binding site [ion binding]; other site
568819008464	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
568819008465	conserved hypothetical protein TIGR01655; Region: yxeA_fam
568819008466	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
568819008467	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
568819008468	peptide binding site [polypeptide binding]; other site
568819008469	Predicted integral membrane protein [Function unknown]; Region: COG5658
568819008470	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
568819008471	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
568819008472	catalytic triad [active]
568819008473	metal binding site [ion binding]; metal-binding site
568819008474	conserved cis-peptide bond; other site
568819008475	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
568819008476	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
568819008477	folate binding site [chemical binding]; other site
568819008478	NADP+ binding site [chemical binding]; other site
568819008479	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
568819008480	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
568819008481	putative NAD(P) binding site [chemical binding]; other site
568819008482	dimer interface [polypeptide binding]; other site
568819008483	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
568819008484	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
568819008485	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819008486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819008487	active site
568819008488	motif I; other site
568819008489	motif II; other site
568819008490	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
568819008491	Uncharacterized conserved protein [Function unknown]; Region: COG1359
568819008492	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
568819008493	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819008494	Walker A/P-loop; other site
568819008495	ATP binding site [chemical binding]; other site
568819008496	Q-loop/lid; other site
568819008497	ABC transporter signature motif; other site
568819008498	Walker B; other site
568819008499	D-loop; other site
568819008500	H-loop/switch region; other site
568819008501	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
568819008502	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
568819008503	FtsX-like permease family; Region: FtsX; pfam02687
568819008504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
568819008505	dimerization interface [polypeptide binding]; other site
568819008506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819008507	dimer interface [polypeptide binding]; other site
568819008508	phosphorylation site [posttranslational modification]
568819008509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819008510	ATP binding site [chemical binding]; other site
568819008511	Mg2+ binding site [ion binding]; other site
568819008512	G-X-G motif; other site
568819008513	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819008514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819008515	active site
568819008516	phosphorylation site [posttranslational modification]
568819008517	intermolecular recognition site; other site
568819008518	dimerization interface [polypeptide binding]; other site
568819008519	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819008520	DNA binding site [nucleotide binding]
568819008521	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
568819008522	Uncharacterized conserved protein [Function unknown]; Region: COG2427
568819008523	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
568819008524	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
568819008525	catalytic loop [active]
568819008526	iron binding site [ion binding]; other site
568819008527	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
568819008528	4Fe-4S binding domain; Region: Fer4; pfam00037
568819008529	4Fe-4S binding domain; Region: Fer4; pfam00037
568819008530	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
568819008531	[4Fe-4S] binding site [ion binding]; other site
568819008532	molybdopterin cofactor binding site; other site
568819008533	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
568819008534	molybdopterin cofactor binding site; other site
568819008535	Uncharacterized conserved protein [Function unknown]; Region: COG1912
568819008536	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819008537	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819008538	putative substrate translocation pore; other site
568819008539	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819008540	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819008541	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
568819008542	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
568819008543	Walker A motif; other site
568819008544	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819008545	SH3-like domain; Region: SH3_8; pfam13457
568819008546	SH3-like domain; Region: SH3_8; pfam13457
568819008547	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819008548	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819008549	active site
568819008550	catalytic tetrad [active]
568819008551	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819008552	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819008553	DNA binding residues [nucleotide binding]
568819008554	putative dimer interface [polypeptide binding]; other site
568819008555	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
568819008556	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
568819008557	23S rRNA interface [nucleotide binding]; other site
568819008558	L3 interface [polypeptide binding]; other site
568819008559	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
568819008560	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
568819008561	dimerization interface 3.5A [polypeptide binding]; other site
568819008562	active site
568819008563	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
568819008564	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
568819008565	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568819008566	Walker A/P-loop; other site
568819008567	ATP binding site [chemical binding]; other site
568819008568	Q-loop/lid; other site
568819008569	ABC transporter signature motif; other site
568819008570	Walker B; other site
568819008571	D-loop; other site
568819008572	H-loop/switch region; other site
568819008573	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
568819008574	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
568819008575	Walker A/P-loop; other site
568819008576	ATP binding site [chemical binding]; other site
568819008577	Q-loop/lid; other site
568819008578	ABC transporter signature motif; other site
568819008579	Walker B; other site
568819008580	D-loop; other site
568819008581	H-loop/switch region; other site
568819008582	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
568819008583	MgtC family; Region: MgtC; pfam02308
568819008584	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
568819008585	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
568819008586	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
568819008587	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
568819008588	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
568819008589	alphaNTD - beta interaction site [polypeptide binding]; other site
568819008590	alphaNTD homodimer interface [polypeptide binding]; other site
568819008591	alphaNTD - beta' interaction site [polypeptide binding]; other site
568819008592	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
568819008593	30S ribosomal protein S11; Validated; Region: PRK05309
568819008594	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
568819008595	30S ribosomal protein S13; Region: bact_S13; TIGR03631
568819008596	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
568819008597	rRNA binding site [nucleotide binding]; other site
568819008598	predicted 30S ribosome binding site; other site
568819008599	adenylate kinase; Reviewed; Region: adk; PRK00279
568819008600	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
568819008601	AMP-binding site [chemical binding]; other site
568819008602	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
568819008603	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
568819008604	SecY translocase; Region: SecY; pfam00344
568819008605	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
568819008606	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
568819008607	23S rRNA binding site [nucleotide binding]; other site
568819008608	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
568819008609	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
568819008610	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
568819008611	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
568819008612	5S rRNA interface [nucleotide binding]; other site
568819008613	L27 interface [polypeptide binding]; other site
568819008614	23S rRNA interface [nucleotide binding]; other site
568819008615	L5 interface [polypeptide binding]; other site
568819008616	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
568819008617	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568819008618	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
568819008619	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
568819008620	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
568819008621	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
568819008622	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
568819008623	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
568819008624	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
568819008625	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
568819008626	RNA binding site [nucleotide binding]; other site
568819008627	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
568819008628	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
568819008629	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
568819008630	23S rRNA interface [nucleotide binding]; other site
568819008631	putative translocon interaction site; other site
568819008632	signal recognition particle (SRP54) interaction site; other site
568819008633	L23 interface [polypeptide binding]; other site
568819008634	trigger factor interaction site; other site
568819008635	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
568819008636	23S rRNA interface [nucleotide binding]; other site
568819008637	5S rRNA interface [nucleotide binding]; other site
568819008638	putative antibiotic binding site [chemical binding]; other site
568819008639	L25 interface [polypeptide binding]; other site
568819008640	L27 interface [polypeptide binding]; other site
568819008641	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
568819008642	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
568819008643	G-X-X-G motif; other site
568819008644	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
568819008645	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
568819008646	putative translocon binding site; other site
568819008647	protein-rRNA interface [nucleotide binding]; other site
568819008648	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
568819008649	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
568819008650	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
568819008651	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
568819008652	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
568819008653	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
568819008654	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
568819008655	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
568819008656	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
568819008657	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
568819008658	UbiA prenyltransferase family; Region: UbiA; pfam01040
568819008659	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
568819008660	ApbE family; Region: ApbE; pfam02424
568819008661	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
568819008662	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
568819008663	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
568819008664	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
568819008665	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
568819008666	Predicted membrane protein [Function unknown]; Region: COG2259
568819008667	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
568819008668	trimer interface [polypeptide binding]; other site
568819008669	Predicted membrane protein [Function unknown]; Region: COG4769
568819008670	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
568819008671	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
568819008672	substrate binding pocket [chemical binding]; other site
568819008673	chain length determination region; other site
568819008674	substrate-Mg2+ binding site; other site
568819008675	catalytic residues [active]
568819008676	aspartate-rich region 1; other site
568819008677	active site lid residues [active]
568819008678	aspartate-rich region 2; other site
568819008679	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
568819008680	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
568819008681	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
568819008682	active site
568819008683	metal binding site [ion binding]; metal-binding site
568819008684	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
568819008685	hypothetical protein; Provisional; Region: PRK02947
568819008686	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819008687	putative active site [active]
568819008688	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
568819008689	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
568819008690	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
568819008691	active site
568819008692	substrate binding pocket [chemical binding]; other site
568819008693	homodimer interaction site [polypeptide binding]; other site
568819008694	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
568819008695	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
568819008696	active site
568819008697	P-loop; other site
568819008698	phosphorylation site [posttranslational modification]
568819008699	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008700	active site
568819008701	phosphorylation site [posttranslational modification]
568819008702	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819008703	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819008704	PRD domain; Region: PRD; pfam00874
568819008705	PRD domain; Region: PRD; pfam00874
568819008706	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819008707	active site
568819008708	P-loop; other site
568819008709	phosphorylation site [posttranslational modification]
568819008710	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008711	active site
568819008712	phosphorylation site [posttranslational modification]
568819008713	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
568819008714	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819008715	Walker A/P-loop; other site
568819008716	ATP binding site [chemical binding]; other site
568819008717	Q-loop/lid; other site
568819008718	ABC transporter signature motif; other site
568819008719	Walker B; other site
568819008720	D-loop; other site
568819008721	H-loop/switch region; other site
568819008722	elongation factor Tu; Reviewed; Region: PRK00049
568819008723	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
568819008724	G1 box; other site
568819008725	GEF interaction site [polypeptide binding]; other site
568819008726	GTP/Mg2+ binding site [chemical binding]; other site
568819008727	Switch I region; other site
568819008728	G2 box; other site
568819008729	G3 box; other site
568819008730	Switch II region; other site
568819008731	G4 box; other site
568819008732	G5 box; other site
568819008733	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
568819008734	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
568819008735	Antibiotic Binding Site [chemical binding]; other site
568819008736	elongation factor G; Reviewed; Region: PRK00007
568819008737	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
568819008738	G1 box; other site
568819008739	putative GEF interaction site [polypeptide binding]; other site
568819008740	GTP/Mg2+ binding site [chemical binding]; other site
568819008741	Switch I region; other site
568819008742	G2 box; other site
568819008743	G3 box; other site
568819008744	Switch II region; other site
568819008745	G4 box; other site
568819008746	G5 box; other site
568819008747	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
568819008748	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
568819008749	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
568819008750	30S ribosomal protein S7; Validated; Region: PRK05302
568819008751	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
568819008752	S17 interaction site [polypeptide binding]; other site
568819008753	S8 interaction site; other site
568819008754	16S rRNA interaction site [nucleotide binding]; other site
568819008755	streptomycin interaction site [chemical binding]; other site
568819008756	23S rRNA interaction site [nucleotide binding]; other site
568819008757	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
568819008758	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
568819008759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
568819008760	Zn2+ binding site [ion binding]; other site
568819008761	Mg2+ binding site [ion binding]; other site
568819008762	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
568819008763	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819008764	Coenzyme A binding pocket [chemical binding]; other site
568819008765	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
568819008766	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819008767	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819008768	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819008769	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568819008770	substrate binding site [chemical binding]; other site
568819008771	hexamer interface [polypeptide binding]; other site
568819008772	metal binding site [ion binding]; metal-binding site
568819008773	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
568819008774	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
568819008775	TPP-binding site [chemical binding]; other site
568819008776	dimer interface [polypeptide binding]; other site
568819008777	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
568819008778	PYR/PP interface [polypeptide binding]; other site
568819008779	dimer interface [polypeptide binding]; other site
568819008780	TPP binding site [chemical binding]; other site
568819008781	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
568819008782	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
568819008783	substrate binding site [chemical binding]; other site
568819008784	hexamer interface [polypeptide binding]; other site
568819008785	metal binding site [ion binding]; metal-binding site
568819008786	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
568819008787	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819008788	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
568819008789	putative NAD(P) binding site [chemical binding]; other site
568819008790	catalytic Zn binding site [ion binding]; other site
568819008791	structural Zn binding site [ion binding]; other site
568819008792	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819008793	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
568819008794	putative NAD(P) binding site [chemical binding]; other site
568819008795	catalytic Zn binding site [ion binding]; other site
568819008796	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
568819008797	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
568819008798	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
568819008799	active site
568819008800	P-loop; other site
568819008801	phosphorylation site [posttranslational modification]
568819008802	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819008803	active site
568819008804	phosphorylation site [posttranslational modification]
568819008805	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819008806	PRD domain; Region: PRD; pfam00874
568819008807	PRD domain; Region: PRD; pfam00874
568819008808	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819008809	active site
568819008810	P-loop; other site
568819008811	phosphorylation site [posttranslational modification]
568819008812	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
568819008813	active site
568819008814	phosphorylation site [posttranslational modification]
568819008815	Predicted membrane protein [Function unknown]; Region: COG4905
568819008816	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
568819008817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
568819008818	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
568819008819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
568819008820	active site
568819008821	Helix-turn-helix domain; Region: HTH_18; pfam12833
568819008822	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
568819008823	Ligand Binding Site [chemical binding]; other site
568819008824	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
568819008825	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
568819008826	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
568819008827	active site
568819008828	DNA binding site [nucleotide binding]
568819008829	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
568819008830	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
568819008831	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
568819008832	active site
568819008833	phosphorylation site [posttranslational modification]
568819008834	intermolecular recognition site; other site
568819008835	dimerization interface [polypeptide binding]; other site
568819008836	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
568819008837	DNA binding site [nucleotide binding]
568819008838	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
568819008839	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
568819008840	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
568819008841	Ligand Binding Site [chemical binding]; other site
568819008842	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
568819008843	GAF domain; Region: GAF_3; pfam13492
568819008844	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
568819008845	dimer interface [polypeptide binding]; other site
568819008846	phosphorylation site [posttranslational modification]
568819008847	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
568819008848	ATP binding site [chemical binding]; other site
568819008849	Mg2+ binding site [ion binding]; other site
568819008850	G-X-G motif; other site
568819008851	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
568819008852	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
568819008853	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819008854	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
568819008855	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819008856	active site
568819008857	P-loop; other site
568819008858	phosphorylation site [posttranslational modification]
568819008859	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819008860	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819008861	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819008862	methionine cluster; other site
568819008863	active site
568819008864	phosphorylation site [posttranslational modification]
568819008865	metal binding site [ion binding]; metal-binding site
568819008866	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
568819008867	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
568819008868	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
568819008869	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
568819008870	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
568819008871	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
568819008872	Soluble P-type ATPase [General function prediction only]; Region: COG4087
568819008873	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
568819008874	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819008875	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819008876	autolysin; Reviewed; Region: PRK06347
568819008877	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
568819008878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008879	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008880	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008881	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
568819008882	Protein of unknown function (DUF970); Region: DUF970; pfam06153
568819008883	thymidylate kinase; Validated; Region: tmk; PRK00698
568819008884	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
568819008885	TMP-binding site; other site
568819008886	ATP-binding site [chemical binding]; other site
568819008887	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
568819008888	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
568819008889	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819008890	catalytic residue [active]
568819008891	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
568819008892	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
568819008893	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819008894	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
568819008895	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
568819008896	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
568819008897	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819008898	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819008899	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819008900	putative active site [active]
568819008901	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
568819008902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819008903	active site
568819008904	motif I; other site
568819008905	motif II; other site
568819008906	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
568819008907	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
568819008908	nudix motif; other site
568819008909	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
568819008910	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
568819008911	active site
568819008912	catalytic tetrad [active]
568819008913	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
568819008914	recombination protein RecR; Reviewed; Region: recR; PRK00076
568819008915	RecR protein; Region: RecR; pfam02132
568819008916	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
568819008917	putative active site [active]
568819008918	putative metal-binding site [ion binding]; other site
568819008919	tetramer interface [polypeptide binding]; other site
568819008920	hypothetical protein; Validated; Region: PRK00153
568819008921	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
568819008922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
568819008923	Walker A motif; other site
568819008924	ATP binding site [chemical binding]; other site
568819008925	Walker B motif; other site
568819008926	arginine finger; other site
568819008927	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
568819008928	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
568819008929	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
568819008930	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819008931	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819008932	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
568819008934	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
568819008935	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
568819008936	N- and C-terminal domain interface [polypeptide binding]; other site
568819008937	active site
568819008938	catalytic site [active]
568819008939	metal binding site [ion binding]; metal-binding site
568819008940	carbohydrate binding site [chemical binding]; other site
568819008941	ATP binding site [chemical binding]; other site
568819008942	SH3-like domain; Region: SH3_8; pfam13457
568819008943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
568819008944	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
568819008945	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819008946	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
568819008947	Walker A/P-loop; other site
568819008948	ATP binding site [chemical binding]; other site
568819008949	Q-loop/lid; other site
568819008950	ABC transporter signature motif; other site
568819008951	Walker B; other site
568819008952	D-loop; other site
568819008953	H-loop/switch region; other site
568819008954	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
568819008955	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819008956	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819008957	Walker A/P-loop; other site
568819008958	ATP binding site [chemical binding]; other site
568819008959	Q-loop/lid; other site
568819008960	ABC transporter signature motif; other site
568819008961	Walker B; other site
568819008962	D-loop; other site
568819008963	H-loop/switch region; other site
568819008964	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
568819008965	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
568819008966	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
568819008967	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
568819008968	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
568819008969	nucleoside/Zn binding site; other site
568819008970	dimer interface [polypeptide binding]; other site
568819008971	catalytic motif [active]
568819008972	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
568819008973	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
568819008974	active site
568819008975	acyl-activating enzyme (AAE) consensus motif; other site
568819008976	putative CoA binding site [chemical binding]; other site
568819008977	AMP binding site [chemical binding]; other site
568819008978	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
568819008979	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
568819008980	active site
568819008981	trimer interface [polypeptide binding]; other site
568819008982	allosteric site; other site
568819008983	active site lid [active]
568819008984	hexamer (dimer of trimers) interface [polypeptide binding]; other site
568819008985	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
568819008986	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
568819008987	DNA binding residues [nucleotide binding]
568819008988	drug binding residues [chemical binding]; other site
568819008989	dimer interface [polypeptide binding]; other site
568819008990	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
568819008991	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
568819008992	Coenzyme A binding pocket [chemical binding]; other site
568819008993	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
568819008994	dimer interface [polypeptide binding]; other site
568819008995	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
568819008996	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
568819008997	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
568819008998	MarR family; Region: MarR; pfam01047
568819008999	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
568819009000	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
568819009001	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
568819009002	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
568819009003	DNA binding residues [nucleotide binding]
568819009004	putative dimer interface [polypeptide binding]; other site
568819009005	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
568819009006	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
568819009007	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819009008	active site
568819009009	motif I; other site
568819009010	motif II; other site
568819009011	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819009012	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819009013	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819009014	putative active site [active]
568819009015	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
568819009016	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819009017	active site
568819009018	phosphorylation site [posttranslational modification]
568819009019	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
568819009020	active site
568819009021	P-loop; other site
568819009022	phosphorylation site [posttranslational modification]
568819009023	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
568819009024	alpha-mannosidase; Provisional; Region: PRK09819
568819009025	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
568819009026	active site
568819009027	metal binding site [ion binding]; metal-binding site
568819009028	catalytic site [active]
568819009029	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
568819009030	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
568819009031	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
568819009032	active site
568819009033	homodimer interface [polypeptide binding]; other site
568819009034	catalytic site [active]
568819009035	glycerate kinase; Region: TIGR00045
568819009036	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819009037	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819009038	DNA binding site [nucleotide binding]
568819009039	domain linker motif; other site
568819009040	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
568819009041	putative dimerization interface [polypeptide binding]; other site
568819009042	putative ligand binding site [chemical binding]; other site
568819009043	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
568819009044	Domain of unknown function DUF21; Region: DUF21; pfam01595
568819009045	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
568819009046	Transporter associated domain; Region: CorC_HlyC; pfam03471
568819009047	NAD-dependent deacetylase; Provisional; Region: PRK00481
568819009048	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
568819009049	NAD+ binding site [chemical binding]; other site
568819009050	substrate binding site [chemical binding]; other site
568819009051	putative Zn binding site [ion binding]; other site
568819009052	Pathogenicity locus; Region: Cdd1; pfam11731
568819009053	drug efflux system protein MdtG; Provisional; Region: PRK09874
568819009054	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009055	putative substrate translocation pore; other site
568819009056	Src Homology 3 domain superfamily; Region: SH3; cl17036
568819009057	Variant SH3 domain; Region: SH3_2; pfam07653
568819009058	peptide ligand binding site [polypeptide binding]; other site
568819009059	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
568819009060	active site
568819009061	intersubunit interactions; other site
568819009062	catalytic residue [active]
568819009063	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
568819009064	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
568819009065	ligand binding site [chemical binding]; other site
568819009066	flexible hinge region; other site
568819009067	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
568819009068	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819009069	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819009070	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819009071	Walker A/P-loop; other site
568819009072	ATP binding site [chemical binding]; other site
568819009073	Q-loop/lid; other site
568819009074	ABC transporter signature motif; other site
568819009075	Walker B; other site
568819009076	D-loop; other site
568819009077	H-loop/switch region; other site
568819009078	TfoX C-terminal domain; Region: TfoX_C; pfam04994
568819009079	seryl-tRNA synthetase; Provisional; Region: PRK05431
568819009080	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
568819009081	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
568819009082	dimer interface [polypeptide binding]; other site
568819009083	active site
568819009084	motif 1; other site
568819009085	motif 2; other site
568819009086	motif 3; other site
568819009087	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
568819009088	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
568819009089	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
568819009090	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
568819009091	glutamine binding [chemical binding]; other site
568819009092	catalytic triad [active]
568819009093	aminodeoxychorismate synthase; Provisional; Region: PRK07508
568819009094	chorismate binding enzyme; Region: Chorismate_bind; cl10555
568819009095	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
568819009096	substrate-cofactor binding pocket; other site
568819009097	homodimer interface [polypeptide binding]; other site
568819009098	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
568819009099	pyridoxal 5'-phosphate binding site [chemical binding]; other site
568819009100	catalytic residue [active]
568819009101	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819009102	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819009103	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819009104	Walker A/P-loop; other site
568819009105	ATP binding site [chemical binding]; other site
568819009106	Q-loop/lid; other site
568819009107	ABC transporter signature motif; other site
568819009108	Walker B; other site
568819009109	D-loop; other site
568819009110	H-loop/switch region; other site
568819009111	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
568819009112	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
568819009113	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
568819009114	Walker A/P-loop; other site
568819009115	ATP binding site [chemical binding]; other site
568819009116	Q-loop/lid; other site
568819009117	ABC transporter signature motif; other site
568819009118	Walker B; other site
568819009119	D-loop; other site
568819009120	H-loop/switch region; other site
568819009121	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961
568819009122	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
568819009123	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
568819009124	Ligand binding site; other site
568819009125	Putative Catalytic site; other site
568819009126	DXD motif; other site
568819009127	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
568819009128	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568819009129	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
568819009130	Predicted acyl esterases [General function prediction only]; Region: COG2936
568819009131	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
568819009132	DNA topoisomerase III; Provisional; Region: PRK07726
568819009133	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
568819009134	active site
568819009135	putative interdomain interaction site [polypeptide binding]; other site
568819009136	putative metal-binding site [ion binding]; other site
568819009137	putative nucleotide binding site [chemical binding]; other site
568819009138	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
568819009139	domain I; other site
568819009140	DNA binding groove [nucleotide binding]
568819009141	phosphate binding site [ion binding]; other site
568819009142	domain II; other site
568819009143	domain III; other site
568819009144	nucleotide binding site [chemical binding]; other site
568819009145	catalytic site [active]
568819009146	domain IV; other site
568819009147	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
568819009148	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
568819009149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
568819009150	ATP binding site [chemical binding]; other site
568819009151	putative Mg++ binding site [ion binding]; other site
568819009152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
568819009153	nucleotide binding region [chemical binding]; other site
568819009154	ATP-binding site [chemical binding]; other site
568819009155	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
568819009156	HRDC domain; Region: HRDC; pfam00570
568819009157	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
568819009158	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
568819009159	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
568819009160	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
568819009161	active site
568819009162	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
568819009163	putative ADP-ribose binding site [chemical binding]; other site
568819009164	putative active site [active]
568819009165	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
568819009166	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819009167	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819009168	ABC transporter; Region: ABC_tran_2; pfam12848
568819009169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
568819009170	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
568819009171	beta-galactosidase; Region: BGL; TIGR03356
568819009172	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819009173	active site
568819009174	P-loop; other site
568819009175	phosphorylation site [posttranslational modification]
568819009176	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
568819009177	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819009178	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819009179	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819009180	nucleotide binding site [chemical binding]; other site
568819009181	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819009182	methionine cluster; other site
568819009183	active site
568819009184	phosphorylation site [posttranslational modification]
568819009185	metal binding site [ion binding]; metal-binding site
568819009186	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819009187	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819009188	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819009189	putative active site [active]
568819009190	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
568819009191	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
568819009192	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
568819009193	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
568819009194	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
568819009195	Walker A/P-loop; other site
568819009196	ATP binding site [chemical binding]; other site
568819009197	Q-loop/lid; other site
568819009198	ABC transporter signature motif; other site
568819009199	Walker B; other site
568819009200	D-loop; other site
568819009201	H-loop/switch region; other site
568819009202	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
568819009203	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
568819009204	ATP-grasp domain; Region: ATP-grasp_4; cl17255
568819009205	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
568819009206	beta-galactosidase; Region: BGL; TIGR03356
568819009207	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
568819009208	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
568819009209	active site turn [active]
568819009210	phosphorylation site [posttranslational modification]
568819009211	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
568819009212	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
568819009213	HPr interaction site; other site
568819009214	glycerol kinase (GK) interaction site [polypeptide binding]; other site
568819009215	active site
568819009216	phosphorylation site [posttranslational modification]
568819009217	transcriptional antiterminator BglG; Provisional; Region: PRK09772
568819009218	CAT RNA binding domain; Region: CAT_RBD; smart01061
568819009219	PRD domain; Region: PRD; pfam00874
568819009220	PRD domain; Region: PRD; pfam00874
568819009221	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
568819009222	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
568819009223	Walker A/P-loop; other site
568819009224	ATP binding site [chemical binding]; other site
568819009225	Q-loop/lid; other site
568819009226	ABC transporter signature motif; other site
568819009227	Walker B; other site
568819009228	D-loop; other site
568819009229	H-loop/switch region; other site
568819009230	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
568819009231	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
568819009232	bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653
568819009233	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
568819009234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009235	putative substrate translocation pore; other site
568819009236	GTP-binding protein YchF; Reviewed; Region: PRK09601
568819009237	YchF GTPase; Region: YchF; cd01900
568819009238	G1 box; other site
568819009239	GTP/Mg2+ binding site [chemical binding]; other site
568819009240	Switch I region; other site
568819009241	G2 box; other site
568819009242	Switch II region; other site
568819009243	G3 box; other site
568819009244	G4 box; other site
568819009245	G5 box; other site
568819009246	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
568819009247	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
568819009248	methionine cluster; other site
568819009249	active site
568819009250	phosphorylation site [posttranslational modification]
568819009251	metal binding site [ion binding]; metal-binding site
568819009252	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
568819009253	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
568819009254	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
568819009255	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
568819009256	active site
568819009257	P-loop; other site
568819009258	phosphorylation site [posttranslational modification]
568819009259	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
568819009260	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
568819009261	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
568819009262	HTH domain; Region: HTH_11; pfam08279
568819009263	Mga helix-turn-helix domain; Region: Mga; pfam05043
568819009264	PRD domain; Region: PRD; pfam00874
568819009265	PRD domain; Region: PRD; pfam00874
568819009266	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
568819009267	active site
568819009268	P-loop; other site
568819009269	phosphorylation site [posttranslational modification]
568819009270	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819009271	active site
568819009272	phosphorylation site [posttranslational modification]
568819009273	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
568819009274	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
568819009275	tetramer interface [polypeptide binding]; other site
568819009276	heme binding pocket [chemical binding]; other site
568819009277	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
568819009278	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
568819009279	ParB-like nuclease domain; Region: ParB; smart00470
568819009280	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
568819009281	salt bridge; other site
568819009282	non-specific DNA binding site [nucleotide binding]; other site
568819009283	sequence-specific DNA binding site [nucleotide binding]; other site
568819009284	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
568819009285	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568819009286	P-loop; other site
568819009287	Magnesium ion binding site [ion binding]; other site
568819009288	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
568819009289	Magnesium ion binding site [ion binding]; other site
568819009290	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
568819009291	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
568819009292	non-specific DNA binding site [nucleotide binding]; other site
568819009293	salt bridge; other site
568819009294	sequence-specific DNA binding site [nucleotide binding]; other site
568819009295	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
568819009296	ParB-like nuclease domain; Region: ParBc; pfam02195
568819009297	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
568819009298	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
568819009299	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
568819009300	putative active site [active]
568819009301	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
568819009302	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
568819009303	nucleotide binding site [chemical binding]; other site
568819009304	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
568819009305	active site
568819009306	phosphorylation site [posttranslational modification]
568819009307	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
568819009308	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819009309	motif II; other site
568819009310	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
568819009311	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
568819009312	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
568819009313	active site
568819009314	P-loop; other site
568819009315	phosphorylation site [posttranslational modification]
568819009316	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819009317	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819009318	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568819009319	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
568819009320	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
568819009321	putative active site cavity [active]
568819009322	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
568819009323	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
568819009324	S-adenosylmethionine binding site [chemical binding]; other site
568819009325	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819009326	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819009327	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819009328	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
568819009329	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
568819009330	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
568819009331	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
568819009332	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
568819009333	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
568819009334	trmE is a tRNA modification GTPase; Region: trmE; cd04164
568819009335	G1 box; other site
568819009336	GTP/Mg2+ binding site [chemical binding]; other site
568819009337	Switch I region; other site
568819009338	G2 box; other site
568819009339	Switch II region; other site
568819009340	G3 box; other site
568819009341	G4 box; other site
568819009342	G5 box; other site
568819009343	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
568819009344	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
568819009345	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
568819009346	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
568819009347	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
568819009348	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
568819009349	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
568819009350	NADP binding site [chemical binding]; other site
568819009351	homodimer interface [polypeptide binding]; other site
568819009352	active site
568819009353	substrate binding site [chemical binding]; other site
568819009354	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009355	D-galactonate transporter; Region: 2A0114; TIGR00893
568819009356	putative substrate translocation pore; other site
568819009357	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819009358	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568819009359	metal binding site [ion binding]; metal-binding site
568819009360	dimer interface [polypeptide binding]; other site
568819009361	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
568819009362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
568819009363	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
568819009364	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
568819009365	metal binding site [ion binding]; metal-binding site
568819009366	dimer interface [polypeptide binding]; other site
568819009367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819009368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
568819009369	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
568819009370	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
568819009371	Leucine-rich repeats; other site
568819009372	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819009373	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
568819009374	Substrate binding site [chemical binding]; other site
568819009375	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819009376	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819009377	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819009378	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
568819009379	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
568819009380	Uncharacterized conserved protein [Function unknown]; Region: COG4198
568819009381	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
568819009382	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
568819009383	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
568819009384	putative ligand binding site [chemical binding]; other site
568819009385	putative NAD binding site [chemical binding]; other site
568819009386	putative catalytic site [active]
568819009387	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
568819009388	L-serine binding site [chemical binding]; other site
568819009389	ACT domain interface; other site
568819009390	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
568819009391	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
568819009392	catalytic residue [active]
568819009393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009394	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819009395	putative substrate translocation pore; other site
568819009396	Transcriptional regulators [Transcription]; Region: MarR; COG1846
568819009397	MarR family; Region: MarR_2; pfam12802
568819009398	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
568819009399	dimer interface [polypeptide binding]; other site
568819009400	FMN binding site [chemical binding]; other site
568819009401	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
568819009402	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
568819009403	catalytic residues [active]
568819009404	beta-phosphoglucomutase; Region: bPGM; TIGR01990
568819009405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
568819009406	motif II; other site
568819009407	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
568819009408	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
568819009409	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
568819009410	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
568819009411	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
568819009412	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
568819009413	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
568819009414	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
568819009415	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
568819009416	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
568819009417	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
568819009418	putative NAD(P) binding site [chemical binding]; other site
568819009419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
568819009420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819009421	dimer interface [polypeptide binding]; other site
568819009422	conserved gate region; other site
568819009423	putative PBP binding loops; other site
568819009424	ABC-ATPase subunit interface; other site
568819009425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
568819009426	dimer interface [polypeptide binding]; other site
568819009427	conserved gate region; other site
568819009428	putative PBP binding loops; other site
568819009429	ABC-ATPase subunit interface; other site
568819009430	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
568819009431	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
568819009432	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
568819009433	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
568819009434	active site
568819009435	homodimer interface [polypeptide binding]; other site
568819009436	catalytic site [active]
568819009437	Transcriptional regulators [Transcription]; Region: PurR; COG1609
568819009438	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
568819009439	DNA binding site [nucleotide binding]
568819009440	domain linker motif; other site
568819009441	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
568819009442	putative dimerization interface [polypeptide binding]; other site
568819009443	putative ligand binding site [chemical binding]; other site
568819009444	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
568819009445	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
568819009446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
568819009447	Coenzyme A binding pocket [chemical binding]; other site
568819009448	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009449	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819009450	putative substrate translocation pore; other site
568819009451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009452	Domain of unknown function (DUF718); Region: DUF718; cl01281
568819009453	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
568819009454	intersubunit interface [polypeptide binding]; other site
568819009455	active site
568819009456	Zn2+ binding site [ion binding]; other site
568819009457	L-rhamnose isomerase; Provisional; Region: PRK01076
568819009458	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
568819009459	N- and C-terminal domain interface [polypeptide binding]; other site
568819009460	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
568819009461	active site
568819009462	putative catalytic site [active]
568819009463	metal binding site [ion binding]; metal-binding site
568819009464	ATP binding site [chemical binding]; other site
568819009465	carbohydrate binding site [chemical binding]; other site
568819009466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
568819009467	putative substrate translocation pore; other site
568819009468	Major Facilitator Superfamily; Region: MFS_1; pfam07690
568819009469	Cupin domain; Region: Cupin_2; pfam07883
568819009470	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
568819009471	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
568819009472	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
568819009473	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
568819009474	G-X-X-G motif; other site
568819009475	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
568819009476	RxxxH motif; other site
568819009477	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
568819009478	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
568819009479	ribonuclease P; Reviewed; Region: rnpA; PRK00499