-- dump date 20240418_041440 -- class Genbank::CDS -- table cds_note -- id note lmo0001 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. lmo0002 binds the polymerase to DNA and acts as a sliding clamp lmo0005 Required for DNA replication; binds preferentially to single-stranded, linear DNA lmo0017 CapA protein (polyglutamate capsule biosynthesis) lmo0019 lmo0019 lmo0029 lmo0029 lmo0036 catalyzes the formation of putrescine from carbamoyl-putrescine during agmatine degradation lmo0038 agmatine deiminase 1; catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis lmo0039 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP lmo0040 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis lmo0043 catalyzes the degradation of arginine to citruline and ammonia lmo0044 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 lmo0046 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit lmo0047 lmo0047 lmo0048 essential for production of a quorum sensing autoinducing peptide lmo0049 lmo0049 lmo0053 in Escherichia coli this protein is wrapped around the base of the L1 stalk lmo0054 unwinds double stranded DNA lmo0055 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis lmo0058 lmo0058 lmo0062 lmo0062 lmo0063 lmo0063 lmo0064 lmo0064 lmo0065 lmo0065 lmo0068 lmo0068 lmo0069 lmo0069 lmo0070 lmo0070 lmo0071 lmo0071 lmo0073 lmo0073 lmo0074 lmo0074 lmo0079 lmo0079 lmo0080 lmo0080 lmo0081 lmo0081 lmo0082 lmo0082 lmo0085 lmo0085 lmo0086 lmo0086 lmo0087 lmo0087 lmo0090 produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a catalytic subunit lmo0092 produces ATP from ADP in the presence of a proton gradient across the membrane; the beta chain is a regulatory subunit lmo0094 lmo0094 lmo0095 lmo0095 lmo0099 lmo0099 lmo0100 lmo0100 lmo0102 lmo0102 lmo0104 lmo0104 lmo0111 lmo0111 lmo0119 lmo0119 lmo0120 lmo0120 lmo0124 lmo0124 lmo0125 lmo0125 lmo0126 lmo0126 lmo0132 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate lmo0138 lmo0138 lmo0139 lmo0139 lmo0140 lmo0140 lmo0141 lmo0141 lmo0142 lmo0142 lmo0143 lmo0143 lmo0144 lmo0144 lmo0147 lmo0147 lmo0148 lmo0148 lmo0149 lmo0149 lmo0150 lmo0150 lmo0151 lmo0151 lmo0156 lmo0156 lmo0161 lmo0161 lmo0162 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA lmo0163 lmo0163 lmo0170 lmo0170 lmo0188 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin lmo0190 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis lmo0193 lmo0193 lmo0196 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus lmo0197 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus lmo0198 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis lmo0199 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP lmo0206 lmo0206 lmo0207 Uncharacterized lipoprotein Lmo0207 precursor. lmo0209 lmo0209 lmo0210 Converts (S)-lactate and NAD(+) to pyruvate and NADH lmo0211 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response lmo0212 lmo0212 lmo0213 Enables the recycling of peptidyl-tRNAs produced at termination of translation lmo0221 Type III pantothenate kinase; type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP lmo0228 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 lmo0233 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents lmo0235 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers lmo0236 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate lmo0237 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation lmo0239 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA lmo0243 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates lmo0244 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function lmo0245 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force lmo0246 Modulates Rho-dependent transcription termination lmo0247 lmo0247 lmo0248 binds directly to 23S ribosomal RNA lmo0249 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA lmo0250 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit lmo0251 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors lmo0254 lmo0254 lmo0258 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme lmo0259 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter lmo0265 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. lmo0270 lmo0270 lmo0273 lmo0273 lmo0274 lmo0274 lmo0279 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates lmo0281 lmo0281 lmo0286 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however lmo0293 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA lmo0296 lmo0296 lmo0302 lmo0302 lmo0304 lmo0304 lmo0306 lmo0306 lmo0307 lmo0307 lmo0310 lmo0310 lmo0311 lmo0311 lmo0316 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP lmo0318 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate lmo0324 lmo0324 lmo0328 lmo0328 lmo0332 lmo0332 lmo0334 lmo0334 lmo0335 lmo0335 lmo0336 lmo0336 lmo0337 lmo0337 lmo0338 lmo0338 lmo0340 lmo0340 lmo0341 lmo0341 lmo0349 lmo0349 lmo0350 lmo0350 lmo0355 Reduces fumarate to succinate in anaerobic bacterial respiration lmo0375 lmo0375 lmo0377 lmo0377 lmo0378 lmo0378 lmo0379 lmo0379 lmo0380 lmo0380 lmo0381 lmo0381 lmo0388 lmo0388 lmo0390 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine lmo0391 lmo0391 lmo0393 lmo0393 lmo0396 catalyzes the formation of L-proline from pyrroline-5-carboxylate lmo0403 lmo0403 lmo0404 lmo0404 lmo0407 lmo0407 lmo0408 lmo0408 lmo0411 catalyzes the formation of phosphoenolpyruvate from pyruvate lmo0412 lmo0412 lmo0413 lmo0413 lmo0417 lmo0417 lmo0418 lmo0418 lmo0422 part of sigC operon that is induced by temperature upshift lmo0423 part of sigC operon induced by temperature upshift lmo0438 lmo0438 lmo0440 lmo0440 lmo0442 lmo0442 lmo0449 lmo0449 lmo0451 lmo0451 lmo0461 lmo0461 lmo0462 lmo0462 lmo0463 lmo0463 lmo0466 lmo0466 lmo0467 lmo0467 lmo0468 lmo0468 lmo0469 lmo0469 lmo0471 lmo0471 lmo0472 lmo0472 lmo0474 lmo0474 lmo0475 lmo0475 lmo0481 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever lmo0482 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance lmo0483 lmo0483 lmo0484 lmo0484; iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source lmo0485 lmo0485 lmo0486 some L32 proteins have zinc finger motifs consisting of CXXC while others do not lmo0487 lmo0487 lmo0490 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate lmo0491 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis lmo0504 lmo0504 lmo0510 lmo0510 lmo0512 lmo0512 lmo0525 lmo0525 lmo0528 hypothetical secreted protein lmo0530 lmo0530 lmo0531 lmo0531 lmo0532 lmo0532 lmo0533 ACT domain-containing protein lmo0539 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources lmo0545 lmo0545 lmo0548 lmo0548 lmo0551 lmo0551 lmo0553 lmo0553 lmo0560 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer lmo0561 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis lmo0562 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers lmo0563 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase lmo0564 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide lmo0565 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide lmo0566 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis lmo0567 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer lmo0568 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ lmo0569 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine lmo0570 catalyzes the formation of L-histidinol from L-histidinol phosphate lmo0572 lmo0572 lmo0576 hypothetical cell wall associated protein lmo0577 lmo0577 lmo0582 iap; p60; autolytic enzyme; can cleave bacterial peptidoglycan; secreted by SecA2 system lmo0583 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins lmo0586 lmo0586 lmo0589 lmo0589 lmo0592 lmo0592 lmo0594 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine lmo0600 lmo0600 lmo0603 lmo0603 lmo0611 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds lmo0615 lmo0615 lmo0617 lmo0617 lmo0619 lmo0619 lmo0620 lmo0620 lmo0623 lmo0623 lmo0625 lmo0625 lmo0628 lmo0628 lmo0629 lmo0629 lmo0632 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site lmo0633 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS lmo0635 lmo0635 lmo0638 lmo0638 lmo0642 lmo0642 lmo0647 lmo0647 lmo0653 lmo0653 lmo0654 lmo0654 lmo0657 lmo0657 lmo0665 lmo0665 lmo0670 lmo0670 lmo0671 lmo0671 lmo0673 lmo0673 lmo0674 lmo0674 lmo0675 lmo0675 lmo0676 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus lmo0677 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus lmo0678 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus lmo0679 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export lmo0680 membrane protein involved in the flagellar export apparatus lmo0681 Positive regulator of class III flagellar genes lmo0682 makes up the distal portion of the flagellar basal body rod lmo0684 lmo0684 lmo0685 With Mot B forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. lmo0687 lmo0687 lmo0690 structural flagella protein lmo0694 lmo0694 lmo0695 lmo0695 lmo0696 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod lmo0697 the hook connects flagellar basal body to the flagellar filament lmo0698 One of three proteins involved in switching the direction of the flagellar rotation lmo0699 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation lmo0700 One of three proteins involved in switching the direction of the flagellar rotation lmo0701 lmo0701 lmo0702 lmo0702 lmo0703 lmo0703 lmo0704 lmo0704 lmo0705 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook lmo0706 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook lmo0707 involved in flagellin assembly lmo0709 lmo0709 lmo0710 with FlgF and C makes up the proximal portion of the flagellar basal body rod lmo0711 with FlgF and B makes up the proximal portion of the flagellar basal body rod lmo0712 forms a junction between the M-ring and FlgB during flagella biosynthesis lmo0713 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod lmo0714 One of three proteins involved in switching the direction of the flagellar rotation lmo0715 lmo0715; binds to and inhibits the function of flagella specific ATPase FliI lmo0716 involved in type III protein export during flagellum assembly lmo0718 lmo0718 lmo0720 lmo0720 lmo0722 catalyzes the formation of acetyl phosphate from pyruvate lmo0727 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source lmo0729 lmo0729 lmo0730 lmo0730 lmo0731 lmo0731 lmo0736 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity lmo0737 lmo0737 lmo0743 lmo0743 lmo0745 lmo0745 lmo0747 lmo0747 lmo0748 lmo0748 lmo0749 lmo0749 lmo0750 lmo0750 lmo0751 lmo0751 lmo0758 lmo0758 lmo0759 lmo0759 lmo0760 lmo0760 lmo0765 lmo0765 lmo0771 lmo0771 lmo0775 lmo0775 lmo0777 lmo0777 lmo0778 lmo0778 lmo0779 lmo0779 lmo0780 lmo0780 lmo0781 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel lmo0788 lmo0788 lmo0791 lmo0791 lmo0797 lmo0797 lmo0799 lmo0799 lmo0804 lmo0804 lmo0805 lmo0805 lmo0812 lmo0812 lmo0819 lmo0819 lmo0821 lmo0821 lmo0824 lmo0824 lmo0831 lmo0831 lmo0834 lmo0834 lmo0838 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate lmo0840 lmo0840 lmo0849 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia lmo0851 lmo0851 lmo0855 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli lmo0863 lmo0863 lmo0864 lmo0864 lmo0867 lmo0867 lmo0868 lmo0868 lmo0869 lmo0869 lmo0870 lmo0870 lmo0879 lmo0879 lmo0881 lmo0881 lmo0884 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX lmo0885 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids lmo0894 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme lmo0895 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase lmo0900 lmo0900 lmo0904 lmo0904 lmo0905 lmo0905 lmo0906 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense lmo0910 lmo0910 lmo0911 lmo0911 lmo0922 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis lmo0928 responsible for recognizing base lesions in the genome and initiating base excision DNA repair lmo0937 lmo0937 lmo0939 lmo0939 lmo0940 lmo0940 lmo0941 lmo0941 lmo0946 lmo0946 lmo0947 hypothetical transport protein lmo0950 lmo0950 lmo0951 lmo0951 lmo0952 lmo0952 lmo0953 lmo0953 lmo0954 lmo0954 lmo0955 lmo0955 lmo0963 metalloprotease lmo0966 lmo0966 lmo0968 catalyzes the phosphorylation of NAD to NADP lmo0970 Catalyzes a key regulatory step in fatty acid biosynthesis lmo0972 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid lmo0974 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid lmo0975 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway lmo0978 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids lmo0985 lmo0985 lmo0988 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein lmo0994 lmo0994 lmo0999 lmo0999 lmo1007 lmo1007 lmo1024 lmo1024 lmo1025 lmo1025 lmo1036 lmo1036 lmo1046 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis lmo1047 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z lmo1051 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) lmo1054 Catalyzes the transfer of acetyl from acetyldihydrolipoamide to coenzyme A to form acetyl CoA lmo1055 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide lmo1056 lmo1056 lmo1059 lmo1059 lmo1068 lmo1068 lmo1072 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate lmo1086 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers lmo1092 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate lmo1093 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers lmo1094 lmo1094 lmo1096 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway lmo1117 lmo1117 lmo1118 lmo1118 lmo1120 lmo1120 lmo1121 lmo1121 lmo1122 lmo1122 lmo1123 lmo1123 lmo1124 lmo1124 lmo1125 lmo1125 lmo1127 lmo1127 lmo1128 lmo1128 lmo1135 lmo1135 lmo1137 lmo1137 lmo1138 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates lmo1139 lmo1139 lmo1140 lmo1140 lmo1146 lmo1146 lmo1162 lmo1162 lmo1169 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin lmo1176 catalyzes the formation of acetaldehyde from ethanolamine lmo1183 lmo1183 lmo1188 lmo1188 lmo1190 lmo1190 lmo1191 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid lmo1192 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group lmo1193 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin lmo1194 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A lmo1195 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a lmo1196 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating lmo1198 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 lmo1199 catalyzes the formation of precorrin-4 from precorrin-3B and S-adenosyl-L-methionine lmo1203 catalyzes the formation of precorrin-3A from precorrin-2 lmo1204 catalyzes the ATP-dependent transport of cobalt lmo1205 periplasmic cobalt binding component of the cobalt transport system lmo1208 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation lmo1214 lmo1214 lmo1219 lmo1219 lmo1221 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily lmo1222 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily lmo1227 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine lmo1228 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids lmo1232 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange lmo1234 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision lmo1235 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. lmo1237 converts L-glutamate to D-glutamate, a component of peptidoglycan lmo1239 hydrolyzes non-standard nucleotides such as xanthine and inosine lmo1241 lmo1241 lmo1243 lmo1243 lmo1245 lmo1245 lmo1247 lmo1247 lmo1249 lmo1249 lmo1256 lmo1256 lmo1257 lmo1257 lmo1258 lmo1258 lmo1259 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway lmo1260 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis lmo1261 lmo1261 lmo1264 lmo1264 lmo1266 lmo1266 lmo1267 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer lmo1268 binds and unfolds substrates as part of the ClpXP protease lmo1272 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) lmo1273 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids lmo1275 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity lmo1278 heat shock protein involved in degradation of misfolded proteins lmo1279 heat shock protein involved in degradation of misfolded proteins lmo1280 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor lmo1286 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling lmo1287 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling lmo1288 S-ribosylhomocysteine lyase; catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 lmo1294 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity lmo1302 Represses a number of genes involved in the response to DNA damage lmo1307 lmo1307 lmo1311 lmo1311 lmo1312 lmo1312 lmo1313 Catalyzes the phosphorylation of UMP to UDP lmo1315 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate lmo1317 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate lmo1318 zinc metalloprotease Lmo1318 lmo1319 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) lmo1320 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity lmo1322 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination lmo1325 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex lmo1327 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock lmo1328 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs lmo1330 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence lmo1348 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein lmo1349 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein lmo1350 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein lmo1351 lmo1351 lmo1352 lmo1352 lmo1359 Regulates rRNA biosynthesis by transcriptional antitermination lmo1360 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate lmo1361 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides lmo1362 catalyzes the bidirectional exonucleolytic cleavage of DNA lmo1365 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate lmo1367 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes lmo1370 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate lmo1371 E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide lmo1376 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate lmo1379 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site lmo1380 lmo1380 lmo1381 lmo1381; catalyzes the hydrolysis of acylphosphate lmo1382 lmo1382 lmo1383 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate lmo1387 catalyzes the formation of L-proline from pyrroline-5-carboxylate lmo1398 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs lmo1399 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP lmo1403 This protein performs the mismatch recognition step during the DNA repair process lmo1404 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex lmo1410 lmo1410 lmo1411 lmo1411 lmo1416 lmo1416 lmo1420 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis lmo1423 lmo1423 lmo1432 lmo1432 lmo1435 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis lmo1436 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive lmo1441 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis lmo1443 lmo1443 lmo1448 catalyzes the hydrolysis of pyrophosphate to phosphate lmo1449 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues lmo1451 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway lmo1454 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium lmo1458 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA lmo1459 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA lmo1460 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA lmo1461 lmo1461 lmo1462 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome lmo1469 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA lmo1470 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase lmo1471 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype lmo1472 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion lmo1473 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria lmo1474 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor lmo1475 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons lmo1476 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III lmo1480 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase lmo1481 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA lmo1486 lmo1486 lmo1488 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria lmo1496 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus lmo1497 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor lmo1503 lmo1503 lmo1504 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA lmo1512 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs lmo1518 lmo1518 lmo1519 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes lmo1522 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine lmo1524 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis lmo1530 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) lmo1531 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step lmo1532 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration lmo1533 plays an essential role in ATP-dependent branch migration of the Holliday junction lmo1536 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis lmo1537 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication lmo1538 Converts glycerol and ADP to glycerol-3-phosphate and ADP lmo1540 involved in the peptidyltransferase reaction during translation lmo1545 blocks the formation of polar Z-ring septums lmo1547 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall lmo1548 functions in MreBCD complex in some organisms lmo1549 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase lmo1552 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain lmo1553 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway lmo1554 catalyzes the formation of porphobilinogen from 5-aminolevulinate lmo1555 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis lmo1556 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis lmo1557 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins lmo1559 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) lmo1560 Primosomal protein that may act to load helicase DnaC during DNA replication lmo1563 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis lmo1564 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases lmo1565 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair lmo1566 Converts isocitrate to alpha ketoglutarate lmo1567 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate lmo1569 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein lmo1570 catalyzes the formation of phosphoenolpyruvate from pyruvate lmo1571 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis lmo1572 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein lmo1573 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits lmo1577 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins lmo1581 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA lmo1583 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein lmo1586 catalyzes the phosphorylation of NAD to NADP lmo1587 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation lmo1589 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate lmo1590 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate lmo1591 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate lmo1592 Required for the synthesis of the thiazole moiety lmo1594 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation lmo1597 lmo1597 lmo1600 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate lmo1605 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis lmo1615 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine lmo1626 lmo1626 lmo1627 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis lmo1628 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate lmo1629 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis lmo1630 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water lmo1631 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate lmo1632 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity lmo1633 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine lmo1640 lmo1640 lmo1641 Catalyzes the conversion of citrate to isocitrate lmo1643 lmo1643 lmo1648 lmo1648 lmo1649 lmo1649 lmo1656 lmo1656 lmo1657 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu lmo1658 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit lmo1659 lmo1659 lmo1664 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase lmo1665 lmo1665 lmo1672 converts O-succinylbenzoate to O-succinylbenzoyl-CoA lmo1673 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA lmo1675 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis lmo1676 synthesizes isochorismate acid from chorismate lmo1677 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate lmo1679 catalyzes the formation of L-homocysteine from cystathionine lmo1681 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine lmo1685 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate lmo1688 Catalyzes a key regulatory step in fatty acid biosynthesis lmo1692 lmo1692 lmo1693 Regulatory protein recX; binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities lmo1700 lmo1700 lmo1701 lmo1701 lmo1707 lmo1707 lmo1709 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn lmo1714 lmo1714 lmo1723 lmo1723 lmo1733 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate lmo1743 lmo1743 lmo1748 lmo1748 lmo1751 Uncharacterized RNA methyltransferase lmo1751 lmo1752 lmo1752 lmo1754 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA lmo1756 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain lmo1760 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer lmo1762 lmo1762 lmo1764 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis lmo1765 involved in de novo purine biosynthesis lmo1767 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis lmo1768 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway lmo1769 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis lmo1770 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis lmo1771 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway lmo1772 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase lmo1773 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide lmo1774 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway lmo1775 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway lmo1779 lmo1779 lmo1780 catalyzes the release of the N-terminal amino acid from a tripeptide lmo1781 lmo1781 lmo1783 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit lmo1785 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits lmo1787 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site lmo1791 lmo1791 lmo1792 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA lmo1793 Essential for efficient processing of 16S rRNA lmo1797 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity lmo1805 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity lmo1806 carries the fatty acid chain in fatty acid biosynthesis lmo1809 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY lmo1810 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria lmo1811 catalyzes branch migration in Holliday junction intermediates lmo1816 required for 70S ribosome assembly lmo1818 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate lmo1819 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity lmo1824 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity lmo1826 lmo1826; Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits lmo1827 Essential for recycling GMP and indirectly, cGMP lmo1831 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate lmo1832 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase lmo1833 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits lmo1835 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity lmo1836 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers lmo1837 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis lmo1838 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis lmo1840 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity lmo1841 lmo1841 lmo1844 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis lmo1846 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones lmo1856 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate lmo1859 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress lmo1860 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress lmo1867 catalyzes the formation of phosphoenolpyruvate from pyruvate lmo1874 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived lmo1878 involved in manganese homeostasis; activates the transcription of the mntABCD operon lmo1885 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine lmo1893 lmo1893 lmo1896 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA lmo1897 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate lmo1899 unwinds DNA lmo1900 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) lmo1901 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine lmo1902 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate lmo1905 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity lmo1906 catalyzes the formation of methylglyoxal from glycerone phosphate lmo1907 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis lmo1915 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate lmo1923 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis lmo1924 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate lmo1925 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis lmo1927 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis lmo1928 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis lmo1929 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate lmo1931 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone lmo1933 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer lmo1936 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate lmo1937 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains lmo1938 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins lmo1939 Catalyzes the formation of (d)CDP from ATP and (d)CMP lmo1951 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB lmo1953 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation lmo1954 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose lmo1971 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr lmo1975 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function lmo1978 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate lmo1980 lmo1980 lmo1983 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis lmo1985 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit lmo1986 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis lmo1987 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis lmo1988 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis lmo1989 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate lmo1990 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D lmo1991 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic lmo1993 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway lmo1995 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate lmo2006 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase lmo2018 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate lmo2019 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile) lmo2023 catalyzes the formation of oxaloacetate from L-aspartate lmo2024 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide lmo2025 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate lmo2035 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis lmo2036 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation lmo2037 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan lmo2038 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate lmo2045 lmo2045 lmo2046 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis lmo2047 some L32 proteins have zinc finger motifs consisting of CXXC while others do not lmo2052 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA lmo2057 converts protoheme IX and farnesyl diphosphate to heme O lmo2063 lmo2063 lmo2064 homopentamer; channel that opens in response to pressure or hypoosmotic shock lmo2065 lmo2065 lmo2066 lmo2066 lmo2068 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth lmo2069 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring lmo2071 lmo2071 lmo2072 modulates transcription in response to the NADH/NAD(+) redox state lmo2079 lmo2079 lmo2080 lmo2080 lmo2081 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling lmo2082 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling lmo2083 lmo2083 lmo2084 lmo2084 lmo2090 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming lmo2091 catalyzes the formation of arginine from (N-L-arginino)succinate lmo2093 lmo2093 lmo2101 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate lmo2102 lmo2102; with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate lmo2103 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta lmo2104 lmo2104 lmo2112 lmo2112 lmo2116 lmo2116 lmo2118 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate lmo2127 lmo2127 lmo2129 lmo2129 lmo2131 lmo2131 lmo2132 lmo2132 lmo2142 lmo2142 lmo2150 lmo2150 lmo2153 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group lmo2154 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE lmo2155 Catalyzes the rate-limiting step in dNTP synthesis lmo2156 lmo2156 lmo2161 lmo2161 lmo2166 lmo2166 lmo2169 lmo2169 lmo2175 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis lmo2185 lmo2185 lmo2186 lmo2186 lmo2187 lmo2187 lmo2190 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence lmo2196 peptide ABC transporter substrate-binding protein lmo2197 lmo2197 lmo2198 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA lmo2202 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs lmo2209 lmo2209 lmo2210 lmo2210 lmo2211 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic lmo2212 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III lmo2218 lmo2218 lmo2220 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates lmo2225 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle lmo2236 catalyzes the conversion of shikimate to 3-dehydroshikimate lmo2239 lmo2239 lmo2252 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate lmo2255 lmo2255 lmo2258 lmo2258 lmo2269 lmo2269 lmo2271 lmo2271 lmo2272 lmo2272 lmo2274 protein gp29 [Bacteriophage A118] lmo2275 Portein gp28 [Bacteriophage A118] lmo2277 lmo2277 lmo2279 holin [Bacteriophage A118] lmo2280 protein gp23 [Bacteriophage A118] lmo2281 protein gp22 [Bacteriophage A118] lmo2282 protein gp21 [Bacteriophage A118] lmo2283 protein gp20 [Bacteriophage A118] lmo2284 Protein gp19 [Bacteriophage A118] lmo2285 Protein gp18 [Bacteriophage A118] lmo2286 Protein gp17 [Bacteriophage A118] lmo2287 tape-measure [Bacteriophage A118] lmo2288 Protein gp15 [Bacteriophage A118] lmo2289 Protein gp14 [Bacteriophage A118] lmo2290 Portein gp13 [Bacteriophage A118] lmo2291 major tail shaft protein [Bacteriophage A118] lmo2292 Portein gp11 [Bacteriophage A118] lmo2293 Protein gp10 [Bacteriophage A118] lmo2294 Protein gp9 [Bacteriophage A118] lmo2295 Protein gp8 [Bacteriophage A118] lmo2298 Protein gp4 [Bacteriophage A118] lmo2299 portal protein [Bacteriophage A118] lmo2302 lmo2302 lmo2305 lmo2305 lmo2309 lmo2309 lmo2310 lmo2310 lmo2311 lmo2311 lmo2312 lmo2312 lmo2314 lmo2314 lmo2318 lmo2318 lmo2320 lmo2320 lmo2321 lmo2321 lmo2322 gp44 [Bacteriophage A118] lmo2323 gp43 [Bacteriophage A118] lmo2325 lmo2325 lmo2327 lmo2327 lmo2332 integrase [Bacteriophage A118] lmo2356 lmo2356 lmo2367 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family lmo2368 lmo2368 lmo2369 induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation lmo2374 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive lmo2375 lmo2375 lmo2378 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali lmo2379 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport lmo2380 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali lmo2381 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone lmo2382 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali lmo2383 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali lmo2384 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali lmo2395 lmo2395 lmo2405 lmo2405 lmo2407 lmo2407 lmo2409 lmo2409 lmo2410 lmo2410 lmo2416 lmo2416 lmo2420 lmo2420 lmo2425 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor lmo2432 lmo2432 lmo2437 lmo2437 lmo2438 lmo2438 lmo2439 lmo2439 lmo2440 lmo2440 lmo2442 lmo2442 lmo2443 lmo2443 lmo2448 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation lmo2454 lmo2454 lmo2455 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis lmo2456 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate lmo2457 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate lmo2458 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway lmo2459 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate lmo2461 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen lmo2465 lmo2465 lmo2466 lmo2466 lmo2468 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates lmo2471 catalyzes the reduction of alpha, beta-unsaturated aldehydes and ketones; reduces the nitro group nitroester and nitroaromatic compounds lmo2479 lmo2479 lmo2481 hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr dephosphorylation lmo2482 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein lmo2483 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system lmo2486 lmo2486 lmo2488 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate lmo2489 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion lmo2491 lmo2491 lmo2492 lmo2492 lmo2495 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation lmo2496 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation lmo2502 lmo2502 lmo2509 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism lmo2510 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins lmo2517 lmo2517 lmo2524 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP lmo2526 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active lmo2528 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane lmo2529 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit lmo2530 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit lmo2531 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit lmo2532 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex lmo2533 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. lmo2534 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 lmo2535 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 lmo2538 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate lmo2539 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate lmo2543 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1 lmo2544 catalyzes the formation of thymidine 5'-phosphate from thymidine lmo2545 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate lmo2546 catalyzes the formation of L-threonine from O-phospho-L-homoserine lmo2547 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine lmo2551 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes lmo2552 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active lmo2559 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer lmo2560 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling lmo2561 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase lmo2562 lmo2562 lmo2566 lmo2566 lmo2567 lmo2567 lmo2568 lmo2568 lmo2570 lmo2570 lmo2574 lmo2574 lmo2578 lmo2578 lmo2584 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth lmo2594 lmo2594 lmo2596 forms a direct contact with the tRNA during translation lmo2597 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit lmo2598 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability lmo2600 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene lmo2601 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene lmo2603 lmo2603 lmo2604 lmo2604 lmo2605 is a component of the macrolide binding site in the peptidyl transferase center lmo2606 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme lmo2607 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 lmo2608 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA lmo2609 smallest protein in the large subunit; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif lmo2610 stimulates the activities of the other two initiation factors, IF-2 and IF-3 lmo2611 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP lmo2612 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase lmo2614 L30 binds domain II of the 23S rRNA and the 5S rRNA lmo2615 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance lmo2616 binds 5S rRNA along with protein L5 and L25 lmo2617 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance lmo2618 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit lmo2620 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 lmo2621 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel lmo2622 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase lmo2623 primary binding protein; helps mediate assembly; involved in translation fidelity lmo2624 one of the stabilizing components for the large ribosomal subunit lmo2626 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation lmo2627 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center lmo2628 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA lmo2629 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation lmo2630 binds third domain of 23S rRNA and protein L29; part of exit tunnel lmo2631 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA lmo2632 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin lmo2633 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex lmo2635 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate lmo2639 lmo2639 lmo2640 lmo2640 lmo2642 lmo2642 lmo2643 lmo2643 lmo2644 lmo2644 lmo2646 lmo2646 lmo2649 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr lmo2653 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu lmo2654 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene lmo2655 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit lmo2656 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance lmo2657 dGTPase type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate lmo2669 lmo2669 lmo2671 lmo2671 lmo2674 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity lmo2675 lmo2675 lmo2681 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions lmo2682 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions lmo2686 lmo2686 lmo2691 cell wall hydrolase; muramidase-2 like protein in Enterococcus faecalis; in Enterococcus faecalis a mutant in this gene has no effect on virulence in mouse models; Listeria monocytogenes MurA in involved in general autolysis; contains an N-terminal muramidase domain and C-terminal LysM repeats for cell wall-anchoring lmo2692 lmo2692 lmo2693 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) lmo2695 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase lmo2702 involved in a recombinational process of DNA repair, independent of the recBC complex lmo2705 lmo2705 lmo2706 lmo2706 lmo2707 lmo2707 lmo2709 lmo2709 lmo2710 lmo2710 lmo2732 lmo2732 lmo2739 Modulates the activities of several enzymes which are inactive in their acetylated form lmo2740 lmo2740 lmo2742 lmo2742 lmo2746 lmo2746 lmo2747 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA lmo2753 lmo2753 lmo2756 decatenates replicating daughter chromosomes lmo2767 lmo2767 lmo2768 hypothetical membrane protein lmo2770 Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine lmo2776 lmo2776 lmo2778 lmo2778 lmo2789 lmo2789 lmo2792 lmo2792 lmo2793 lmo2793 lmo2801 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate lmo2802 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA lmo2803 lmo2803 lmo2804 lmo2804 lmo2805 hypothetical secreted protein lmo2806 hypothetical secreted protein lmo2807 hypothetical secreted protein lmo2808 hypothetical secreted protein lmo2809 hypothetical secreted protein lmo2810 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs lmo2811 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE lmo2813 lmo2813 lmo2815 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis lmo2822 lmo2822 lmo2825 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine lmo2828 lmo2828 lmo2843 lmo2843 lmo2848 catalyzes the formation of L-rhamnulose from L-rhamnose lmo2852 lmo2852 lmo2855 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates lmo2856 in Escherichia coli transcription of this gene is enhanced by polyamines