-- dump date 20140619_132420 -- class Genbank::misc_feature -- table misc_feature_note -- id note 169963000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 169963000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 169963000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963000004 Walker A motif; other site 169963000005 ATP binding site [chemical binding]; other site 169963000006 Walker B motif; other site 169963000007 arginine finger; other site 169963000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 169963000009 DnaA box-binding interface [nucleotide binding]; other site 169963000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 169963000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 169963000012 putative DNA binding surface [nucleotide binding]; other site 169963000013 dimer interface [polypeptide binding]; other site 169963000014 beta-clamp/clamp loader binding surface; other site 169963000015 beta-clamp/translesion DNA polymerase binding surface; other site 169963000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 169963000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 169963000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 169963000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 169963000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 169963000021 Walker A/P-loop; other site 169963000022 ATP binding site [chemical binding]; other site 169963000023 Q-loop/lid; other site 169963000024 ABC transporter signature motif; other site 169963000025 Walker B; other site 169963000026 D-loop; other site 169963000027 H-loop/switch region; other site 169963000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 169963000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963000030 ATP binding site [chemical binding]; other site 169963000031 Mg2+ binding site [ion binding]; other site 169963000032 G-X-G motif; other site 169963000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 169963000034 anchoring element; other site 169963000035 dimer interface [polypeptide binding]; other site 169963000036 ATP binding site [chemical binding]; other site 169963000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 169963000038 active site 169963000039 putative metal-binding site [ion binding]; other site 169963000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 169963000041 DNA gyrase subunit A; Validated; Region: PRK05560 169963000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 169963000043 CAP-like domain; other site 169963000044 active site 169963000045 primary dimer interface [polypeptide binding]; other site 169963000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963000052 cardiolipin synthetase; Reviewed; Region: PRK12452 169963000053 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 169963000054 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 169963000055 putative active site [active] 169963000056 catalytic site [active] 169963000057 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 169963000058 putative active site [active] 169963000059 catalytic site [active] 169963000060 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 169963000061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963000062 Coenzyme A binding pocket [chemical binding]; other site 169963000063 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 169963000064 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 169963000065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 169963000066 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 169963000067 diphosphomevalonate decarboxylase; Region: PLN02407 169963000068 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 169963000069 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 169963000070 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 169963000071 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 169963000072 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 169963000073 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 169963000074 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 169963000075 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 169963000076 D-pathway; other site 169963000077 Putative ubiquinol binding site [chemical binding]; other site 169963000078 Low-spin heme (heme b) binding site [chemical binding]; other site 169963000079 Putative water exit pathway; other site 169963000080 Binuclear center (heme o3/CuB) [ion binding]; other site 169963000081 K-pathway; other site 169963000082 Putative proton exit pathway; other site 169963000083 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 169963000084 Subunit I/III interface [polypeptide binding]; other site 169963000085 Subunit III/IV interface [polypeptide binding]; other site 169963000086 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 169963000087 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 169963000088 putative active site [active] 169963000089 putative metal binding site [ion binding]; other site 169963000090 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 169963000091 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963000092 Bacterial SH3 domain; Region: SH3_3; pfam08239 169963000093 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 169963000094 putative active site [active] 169963000095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963000096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963000097 DNA-binding site [nucleotide binding]; DNA binding site 169963000098 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 169963000099 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963000100 active pocket/dimerization site; other site 169963000101 active site 169963000102 phosphorylation site [posttranslational modification] 169963000103 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 169963000104 active site 169963000105 phosphorylation site [posttranslational modification] 169963000106 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 169963000107 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 169963000108 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963000109 putative active site [active] 169963000110 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 169963000111 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 169963000112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963000113 active site turn [active] 169963000114 phosphorylation site [posttranslational modification] 169963000115 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963000116 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 169963000117 HPr interaction site; other site 169963000118 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963000119 active site 169963000120 phosphorylation site [posttranslational modification] 169963000121 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 169963000122 putative dimer interface [polypeptide binding]; other site 169963000123 catalytic triad [active] 169963000124 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963000125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000126 active site 169963000127 motif I; other site 169963000128 motif II; other site 169963000129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963000131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963000132 DNA binding site [nucleotide binding] 169963000133 domain linker motif; other site 169963000134 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 169963000135 dimerization interface [polypeptide binding]; other site 169963000136 putative ligand binding site [chemical binding]; other site 169963000137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963000138 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963000139 nucleotide binding site [chemical binding]; other site 169963000140 Butyrate kinase [Energy production and conversion]; Region: COG3426 169963000141 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 169963000142 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 169963000143 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963000144 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 169963000145 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 169963000146 dimer interface [polypeptide binding]; other site 169963000147 active site 169963000148 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 169963000149 dimer interface [polypeptide binding]; other site 169963000150 active site 169963000151 putrescine carbamoyltransferase; Provisional; Region: PRK02255 169963000152 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 169963000153 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 169963000154 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 169963000155 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963000156 agmatine deiminase; Region: agmatine_aguA; TIGR03380 169963000157 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 169963000158 putative substrate binding site [chemical binding]; other site 169963000159 nucleotide binding site [chemical binding]; other site 169963000160 nucleotide binding site [chemical binding]; other site 169963000161 homodimer interface [polypeptide binding]; other site 169963000162 agmatine deiminase; Region: agmatine_aguA; TIGR03380 169963000163 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963000164 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963000165 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963000166 putative active site [active] 169963000167 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 169963000168 arginine deiminase; Provisional; Region: PRK01388 169963000169 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 169963000170 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 169963000171 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 169963000172 dimer interface [polypeptide binding]; other site 169963000173 ssDNA binding site [nucleotide binding]; other site 169963000174 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963000175 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 169963000176 Predicted membrane protein [Function unknown]; Region: COG3212 169963000177 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 169963000178 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 169963000179 putative accessory gene regulator protein; Provisional; Region: PRK01100 169963000180 cyclic lactone autoinducer peptide; Region: quorum_AgrD; TIGR04223 169963000181 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 169963000182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963000183 ATP binding site [chemical binding]; other site 169963000184 Mg2+ binding site [ion binding]; other site 169963000185 G-X-G motif; other site 169963000186 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 169963000187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963000188 active site 169963000189 phosphorylation site [posttranslational modification] 169963000190 intermolecular recognition site; other site 169963000191 dimerization interface [polypeptide binding]; other site 169963000192 LytTr DNA-binding domain; Region: LytTR; pfam04397 169963000193 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 169963000194 PAS domain; Region: PAS_8; pfam13188 169963000195 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 169963000196 metal binding site [ion binding]; metal-binding site 169963000197 DHH family; Region: DHH; pfam01368 169963000198 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 169963000199 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 169963000200 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 169963000201 replicative DNA helicase; Provisional; Region: PRK05748 169963000202 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 169963000203 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 169963000204 Walker A motif; other site 169963000205 ATP binding site [chemical binding]; other site 169963000206 Walker B motif; other site 169963000207 DNA binding loops [nucleotide binding] 169963000208 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 169963000209 GDP-binding site [chemical binding]; other site 169963000210 ACT binding site; other site 169963000211 IMP binding site; other site 169963000212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 169963000213 Predicted membrane protein [Function unknown]; Region: COG1511 169963000214 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 169963000215 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 169963000216 Uncharacterized small protein [Function unknown]; Region: COG5417 169963000217 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 169963000218 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 169963000219 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 169963000220 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 169963000221 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 169963000222 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 169963000223 Uncharacterized conserved protein [Function unknown]; Region: COG5444 169963000224 Pre-toxin TG; Region: PT-TG; pfam14449 169963000225 ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496 169963000226 active site 169963000227 conformational flexibility of ligand binding pocket; other site 169963000228 ADP-ribosylating toxin turn-turn motif; other site 169963000229 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 169963000230 Immunity protein 36; Region: Imm36; pfam15597 169963000231 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 169963000232 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 169963000233 tetramer interface [polypeptide binding]; other site 169963000234 active site 169963000235 Mg2+/Mn2+ binding site [ion binding]; other site 169963000236 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 169963000237 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 169963000238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963000239 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 169963000240 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 169963000241 DNA binding site [nucleotide binding] 169963000242 active site 169963000243 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 169963000244 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 169963000245 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 169963000246 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 169963000247 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 169963000248 putative ligand binding site [chemical binding]; other site 169963000249 putative NAD binding site [chemical binding]; other site 169963000250 catalytic site [active] 169963000251 LXG domain of WXG superfamily; Region: LXG; pfam04740 169963000252 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963000253 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963000254 DNA binding residues [nucleotide binding] 169963000255 putative dimer interface [polypeptide binding]; other site 169963000256 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963000257 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 169963000258 active site 169963000259 catalytic tetrad [active] 169963000260 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000261 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963000262 ATP synthase subunit C; Region: ATP-synt_C; cl00466 169963000263 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 169963000264 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 169963000265 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 169963000266 Walker A motif; other site 169963000267 ATP binding site [chemical binding]; other site 169963000268 Walker B motif; other site 169963000269 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 169963000270 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 169963000271 core domain interface [polypeptide binding]; other site 169963000272 delta subunit interface [polypeptide binding]; other site 169963000273 epsilon subunit interface [polypeptide binding]; other site 169963000274 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 169963000275 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 169963000276 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 169963000277 alpha subunit interaction interface [polypeptide binding]; other site 169963000278 Walker A motif; other site 169963000279 ATP binding site [chemical binding]; other site 169963000280 Walker B motif; other site 169963000281 inhibitor binding site; inhibition site 169963000282 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 169963000283 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 169963000284 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000285 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 169963000286 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963000287 active pocket/dimerization site; other site 169963000288 active site 169963000289 phosphorylation site [posttranslational modification] 169963000290 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 169963000291 active site 169963000292 phosphorylation site [posttranslational modification] 169963000293 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 169963000294 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 169963000295 Domain of unknown function (DUF956); Region: DUF956; pfam06115 169963000296 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 169963000297 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963000298 dimerization interface [polypeptide binding]; other site 169963000299 putative DNA binding site [nucleotide binding]; other site 169963000300 Uncharacterized conserved protein [Function unknown]; Region: COG1359 169963000301 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 169963000302 dimer interface [polypeptide binding]; other site 169963000303 FMN binding site [chemical binding]; other site 169963000304 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 169963000305 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 169963000306 active site 169963000307 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 169963000308 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 169963000309 Interdomain contacts; other site 169963000310 Cytokine receptor motif; other site 169963000311 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 169963000312 aromatic chitin/cellulose binding site residues [chemical binding]; other site 169963000313 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963000314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963000315 nucleotide binding site [chemical binding]; other site 169963000316 butyrate kinase; Region: butyr_kinase; TIGR02707 169963000317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963000318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963000319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963000320 Walker A/P-loop; other site 169963000321 ATP binding site [chemical binding]; other site 169963000322 Q-loop/lid; other site 169963000323 ABC transporter signature motif; other site 169963000324 Walker B; other site 169963000325 D-loop; other site 169963000326 H-loop/switch region; other site 169963000327 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963000328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963000329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963000330 Walker A/P-loop; other site 169963000331 ATP binding site [chemical binding]; other site 169963000332 Q-loop/lid; other site 169963000333 ABC transporter signature motif; other site 169963000334 Walker B; other site 169963000335 D-loop; other site 169963000336 H-loop/switch region; other site 169963000337 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 169963000338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963000339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 169963000340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963000341 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963000342 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 169963000343 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 169963000344 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000345 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 169963000346 ligand binding site [chemical binding]; other site 169963000347 flexible hinge region; other site 169963000348 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963000349 Domain of unknown function (DUF955); Region: DUF955; pfam06114 169963000350 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963000351 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963000352 non-specific DNA binding site [nucleotide binding]; other site 169963000353 salt bridge; other site 169963000354 sequence-specific DNA binding site [nucleotide binding]; other site 169963000355 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 169963000356 Predicted secreted protein [Function unknown]; Region: COG5437 169963000357 Phage-related protein [Function unknown]; Region: COG5412 169963000358 putative minor structural protein; Region: PHA01351 169963000359 membrane protein P6; Region: PHA01399 169963000360 Phage tail protein; Region: Sipho_tail; pfam05709 169963000361 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 169963000362 Predicted membrane protein [Function unknown]; Region: COG1511 169963000363 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 169963000364 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 169963000365 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 169963000366 active site 169963000367 metal binding site [ion binding]; metal-binding site 169963000368 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 169963000369 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 169963000370 putative active site [active] 169963000371 putative metal binding site [ion binding]; other site 169963000372 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 169963000373 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 169963000374 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 169963000375 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 169963000376 active site 169963000377 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 169963000378 Uncharacterized conserved protein [Function unknown]; Region: COG3592 169963000379 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963000380 Coenzyme A binding pocket [chemical binding]; other site 169963000381 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 169963000382 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 169963000383 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 169963000384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000385 dimer interface [polypeptide binding]; other site 169963000386 conserved gate region; other site 169963000387 putative PBP binding loops; other site 169963000388 ABC-ATPase subunit interface; other site 169963000389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 169963000390 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 169963000391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000392 dimer interface [polypeptide binding]; other site 169963000393 conserved gate region; other site 169963000394 putative PBP binding loops; other site 169963000395 ABC-ATPase subunit interface; other site 169963000396 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 169963000397 LXG domain of WXG superfamily; Region: LXG; pfam04740 169963000398 sodium/calcium exchanger 1; Region: caca; TIGR00845 169963000399 sodium/calcium exchanger 1; Region: caca; TIGR00845 169963000400 Immunity protein 45; Region: Imm45; pfam15603 169963000401 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 169963000402 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 169963000403 peptide binding site [polypeptide binding]; other site 169963000404 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 169963000405 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 169963000406 metal binding site [ion binding]; metal-binding site 169963000407 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 169963000408 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 169963000409 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 169963000410 ABC-ATPase subunit interface; other site 169963000411 dimer interface [polypeptide binding]; other site 169963000412 putative PBP binding regions; other site 169963000413 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000414 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963000415 ligand binding site [chemical binding]; other site 169963000416 flexible hinge region; other site 169963000417 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 169963000418 DEAD_2; Region: DEAD_2; pfam06733 169963000419 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 169963000420 sugar phosphate phosphatase; Provisional; Region: PRK10513 169963000421 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000422 active site 169963000423 motif I; other site 169963000424 motif II; other site 169963000425 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963000426 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 169963000427 Collagen binding domain; Region: Collagen_bind; pfam05737 169963000428 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000429 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000430 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000431 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000432 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963000433 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 169963000434 Collagen binding domain; Region: Collagen_bind; pfam05737 169963000435 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000436 Cna protein B-type domain; Region: Cna_B; pfam05738 169963000437 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963000438 DNA polymerase III subunit delta'; Validated; Region: PRK08058 169963000439 DNA polymerase III subunit delta'; Validated; Region: PRK08485 169963000440 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 169963000441 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 169963000442 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 169963000443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963000444 S-adenosylmethionine binding site [chemical binding]; other site 169963000445 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 169963000446 GIY-YIG motif/motif A; other site 169963000447 putative active site [active] 169963000448 putative metal binding site [ion binding]; other site 169963000449 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 169963000450 putative SAM binding site [chemical binding]; other site 169963000451 putative homodimer interface [polypeptide binding]; other site 169963000452 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 169963000453 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 169963000454 Sugar transport protein; Region: Sugar_transport; pfam06800 169963000455 Uncharacterized conserved protein [Function unknown]; Region: COG5361 169963000456 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 169963000457 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 169963000458 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963000459 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000460 Leucine rich repeat; Region: LRR_8; pfam13855 169963000461 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000462 LRR adjacent; Region: LRR_adjacent; pfam08191 169963000463 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963000464 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963000467 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 169963000468 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963000469 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963000470 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 169963000471 Sugar transport protein; Region: Sugar_transport; pfam06800 169963000472 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 169963000473 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 169963000474 active site 169963000475 HIGH motif; other site 169963000476 KMSKS motif; other site 169963000477 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 169963000478 tRNA binding surface [nucleotide binding]; other site 169963000479 anticodon binding site; other site 169963000480 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 169963000481 dimer interface [polypeptide binding]; other site 169963000482 putative tRNA-binding site [nucleotide binding]; other site 169963000483 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963000484 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963000485 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963000486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963000487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000488 dimer interface [polypeptide binding]; other site 169963000489 conserved gate region; other site 169963000490 putative PBP binding loops; other site 169963000491 ABC-ATPase subunit interface; other site 169963000492 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000494 dimer interface [polypeptide binding]; other site 169963000495 conserved gate region; other site 169963000496 putative PBP binding loops; other site 169963000497 ABC-ATPase subunit interface; other site 169963000498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963000499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 169963000500 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 169963000501 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 169963000502 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 169963000503 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 169963000504 active site 169963000505 catalytic site [active] 169963000506 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 169963000507 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 169963000508 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 169963000509 trimer interface [polypeptide binding]; other site 169963000510 active site 169963000511 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 169963000512 catalytic site [active] 169963000513 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 169963000514 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 169963000515 Ca binding site [ion binding]; other site 169963000516 active site 169963000517 catalytic site [active] 169963000518 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 169963000519 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 169963000520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 169963000521 active site 169963000522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 169963000523 Domain of unknown function (DUF348); Region: DUF348; pfam03990 169963000524 Domain of unknown function (DUF348); Region: DUF348; pfam03990 169963000525 Domain of unknown function (DUF348); Region: DUF348; pfam03990 169963000526 G5 domain; Region: G5; pfam07501 169963000527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 169963000528 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 169963000529 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 169963000530 putative active site [active] 169963000531 putative metal binding site [ion binding]; other site 169963000532 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 169963000533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963000534 S-adenosylmethionine binding site [chemical binding]; other site 169963000535 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 169963000536 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 169963000537 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 169963000538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 169963000539 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 169963000540 putative active site [active] 169963000541 YdjC motif; other site 169963000542 Mg binding site [ion binding]; other site 169963000543 putative homodimer interface [polypeptide binding]; other site 169963000544 pur operon repressor; Provisional; Region: PRK09213 169963000545 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 169963000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963000547 active site 169963000548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 169963000549 HlyD family secretion protein; Region: HlyD_3; pfam13437 169963000550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963000551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963000552 Walker A/P-loop; other site 169963000553 ATP binding site [chemical binding]; other site 169963000554 Q-loop/lid; other site 169963000555 ABC transporter signature motif; other site 169963000556 Walker B; other site 169963000557 D-loop; other site 169963000558 H-loop/switch region; other site 169963000559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963000560 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963000561 FtsX-like permease family; Region: FtsX; pfam02687 169963000562 regulatory protein SpoVG; Reviewed; Region: PRK13259 169963000563 regulatory protein SpoVG; Reviewed; Region: PRK13259 169963000564 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 169963000565 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 169963000566 Substrate binding site; other site 169963000567 Mg++ binding site; other site 169963000568 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 169963000569 active site 169963000570 substrate binding site [chemical binding]; other site 169963000571 CoA binding site [chemical binding]; other site 169963000572 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 169963000573 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 169963000574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963000575 active site 169963000576 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000577 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963000578 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963000579 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 169963000580 active site 169963000581 catalytic site [active] 169963000582 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 169963000583 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 169963000584 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 169963000585 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 169963000586 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 169963000587 active site 169963000588 Zn binding site [ion binding]; other site 169963000589 ActA Protein; Region: ActA; pfam05058 169963000590 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 169963000591 Zn binding site [ion binding]; other site 169963000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 169963000593 hypothetical protein; Provisional; Region: PRK01119 169963000594 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 169963000595 active site 169963000596 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 169963000597 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 169963000598 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963000599 NAD binding site [chemical binding]; other site 169963000600 dimer interface [polypeptide binding]; other site 169963000601 substrate binding site [chemical binding]; other site 169963000602 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 169963000603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 169963000604 5S rRNA interface [nucleotide binding]; other site 169963000605 CTC domain interface [polypeptide binding]; other site 169963000606 L16 interface [polypeptide binding]; other site 169963000607 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 169963000608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963000609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963000610 Coenzyme A binding pocket [chemical binding]; other site 169963000611 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 169963000612 putative active site [active] 169963000613 catalytic residue [active] 169963000614 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 169963000615 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 169963000616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963000617 ATP binding site [chemical binding]; other site 169963000618 putative Mg++ binding site [ion binding]; other site 169963000619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963000620 nucleotide binding region [chemical binding]; other site 169963000621 ATP-binding site [chemical binding]; other site 169963000622 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 169963000623 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 169963000624 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 169963000625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963000626 RNA binding surface [nucleotide binding]; other site 169963000627 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 169963000628 hypothetical protein; Provisional; Region: PRK08582 169963000629 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 169963000630 RNA binding site [nucleotide binding]; other site 169963000631 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 169963000632 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 169963000633 Ligand Binding Site [chemical binding]; other site 169963000634 TilS substrate C-terminal domain; Region: TilS_C; smart00977 169963000635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963000636 active site 169963000637 FtsH Extracellular; Region: FtsH_ext; pfam06480 169963000638 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 169963000639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963000640 Walker A motif; other site 169963000641 ATP binding site [chemical binding]; other site 169963000642 Walker B motif; other site 169963000643 arginine finger; other site 169963000644 Peptidase family M41; Region: Peptidase_M41; pfam01434 169963000645 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963000646 nucleotide binding site [chemical binding]; other site 169963000647 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 169963000648 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 169963000649 dimerization interface [polypeptide binding]; other site 169963000650 domain crossover interface; other site 169963000651 redox-dependent activation switch; other site 169963000652 cysteine synthase; Region: PLN02565 169963000653 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 169963000654 dimer interface [polypeptide binding]; other site 169963000655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963000656 catalytic residue [active] 169963000657 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 169963000658 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 169963000659 substrate binding pocket [chemical binding]; other site 169963000660 dimer interface [polypeptide binding]; other site 169963000661 inhibitor binding site; inhibition site 169963000662 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 169963000663 homooctamer interface [polypeptide binding]; other site 169963000664 active site 169963000665 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 169963000666 catalytic center binding site [active] 169963000667 ATP binding site [chemical binding]; other site 169963000668 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 169963000669 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 169963000670 FMN binding site [chemical binding]; other site 169963000671 active site 169963000672 catalytic residues [active] 169963000673 substrate binding site [chemical binding]; other site 169963000674 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 169963000675 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 169963000676 dimer interface [polypeptide binding]; other site 169963000677 putative anticodon binding site; other site 169963000678 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 169963000679 motif 1; other site 169963000680 active site 169963000681 motif 2; other site 169963000682 motif 3; other site 169963000683 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 169963000684 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 169963000685 UvrB/uvrC motif; Region: UVR; pfam02151 169963000686 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 169963000687 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 169963000688 ADP binding site [chemical binding]; other site 169963000689 phosphagen binding site; other site 169963000690 substrate specificity loop; other site 169963000691 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 169963000692 Clp amino terminal domain; Region: Clp_N; pfam02861 169963000693 Clp amino terminal domain; Region: Clp_N; pfam02861 169963000694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963000695 Walker A motif; other site 169963000696 ATP binding site [chemical binding]; other site 169963000697 Walker B motif; other site 169963000698 arginine finger; other site 169963000699 UvrB/uvrC motif; Region: UVR; pfam02151 169963000700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963000701 Walker A motif; other site 169963000702 ATP binding site [chemical binding]; other site 169963000703 Walker B motif; other site 169963000704 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 169963000705 DNA repair protein RadA; Provisional; Region: PRK11823 169963000706 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 169963000707 Walker A motif/ATP binding site; other site 169963000708 ATP binding site [chemical binding]; other site 169963000709 Walker B motif; other site 169963000710 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 169963000711 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 169963000712 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 169963000713 putative active site [active] 169963000714 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 169963000715 substrate binding site; other site 169963000716 dimer interface; other site 169963000717 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 169963000718 homotrimer interaction site [polypeptide binding]; other site 169963000719 zinc binding site [ion binding]; other site 169963000720 CDP-binding sites; other site 169963000721 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 169963000722 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 169963000723 active site 169963000724 HIGH motif; other site 169963000725 KMSKS motif; other site 169963000726 serine O-acetyltransferase; Region: cysE; TIGR01172 169963000727 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 169963000728 trimer interface [polypeptide binding]; other site 169963000729 active site 169963000730 substrate binding site [chemical binding]; other site 169963000731 CoA binding site [chemical binding]; other site 169963000732 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 169963000733 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 169963000734 active site 169963000735 HIGH motif; other site 169963000736 KMSKS motif; other site 169963000737 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 169963000738 tRNA binding surface [nucleotide binding]; other site 169963000739 anticodon binding site; other site 169963000740 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 169963000741 active site 169963000742 metal binding site [ion binding]; metal-binding site 169963000743 dimerization interface [polypeptide binding]; other site 169963000744 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 169963000745 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 169963000746 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 169963000747 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 169963000748 RNA polymerase factor sigma-70; Validated; Region: PRK08295 169963000749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 169963000750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 169963000751 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 169963000752 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 169963000753 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 169963000754 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 169963000755 putative homodimer interface [polypeptide binding]; other site 169963000756 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 169963000757 heterodimer interface [polypeptide binding]; other site 169963000758 homodimer interface [polypeptide binding]; other site 169963000759 Immunity protein 38; Region: Imm38; pfam15599 169963000760 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 169963000761 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 169963000762 23S rRNA interface [nucleotide binding]; other site 169963000763 L7/L12 interface [polypeptide binding]; other site 169963000764 putative thiostrepton binding site; other site 169963000765 L25 interface [polypeptide binding]; other site 169963000766 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 169963000767 mRNA/rRNA interface [nucleotide binding]; other site 169963000768 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 169963000769 23S rRNA interface [nucleotide binding]; other site 169963000770 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 169963000771 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 169963000772 core dimer interface [polypeptide binding]; other site 169963000773 peripheral dimer interface [polypeptide binding]; other site 169963000774 L10 interface [polypeptide binding]; other site 169963000775 L11 interface [polypeptide binding]; other site 169963000776 putative EF-Tu interaction site [polypeptide binding]; other site 169963000777 putative EF-G interaction site [polypeptide binding]; other site 169963000778 Penicillinase repressor; Region: Penicillinase_R; pfam03965 169963000779 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 169963000780 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 169963000781 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 169963000782 Methyltransferase domain; Region: Methyltransf_31; pfam13847 169963000783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963000784 S-adenosylmethionine binding site [chemical binding]; other site 169963000785 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 169963000786 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 169963000787 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 169963000788 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 169963000789 RPB12 interaction site [polypeptide binding]; other site 169963000790 RPB1 interaction site [polypeptide binding]; other site 169963000791 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 169963000792 RPB10 interaction site [polypeptide binding]; other site 169963000793 RPB11 interaction site [polypeptide binding]; other site 169963000794 RPB3 interaction site [polypeptide binding]; other site 169963000795 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 169963000796 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 169963000797 beta and beta' interface [polypeptide binding]; other site 169963000798 beta' and sigma factor interface [polypeptide binding]; other site 169963000799 Zn-binding [ion binding]; other site 169963000800 active site region [active] 169963000801 catalytic site [active] 169963000802 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 169963000803 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 169963000804 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 169963000805 G-loop; other site 169963000806 DNA binding site [nucleotide binding] 169963000807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000808 active site 169963000809 motif I; other site 169963000810 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 169963000811 motif II; other site 169963000812 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963000813 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963000814 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963000815 Leucine rich repeat; Region: LRR_8; pfam13855 169963000816 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000817 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000818 Leucine rich repeat; Region: LRR_8; pfam13855 169963000819 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000820 LRR adjacent; Region: LRR_adjacent; pfam08191 169963000821 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963000822 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963000823 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963000824 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963000825 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000826 Leucine rich repeat; Region: LRR_8; pfam13855 169963000827 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000828 Leucine rich repeat; Region: LRR_8; pfam13855 169963000829 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000830 Leucine rich repeat; Region: LRR_8; pfam13855 169963000831 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000832 LRR adjacent; Region: LRR_adjacent; pfam08191 169963000833 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963000834 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963000835 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963000836 Leucine rich repeat; Region: LRR_8; pfam13855 169963000837 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000838 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000839 Leucine rich repeat; Region: LRR_8; pfam13855 169963000840 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000841 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963000842 LRR adjacent; Region: LRR_adjacent; pfam08191 169963000843 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963000844 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963000845 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 169963000846 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 169963000847 metal binding site [ion binding]; metal-binding site 169963000848 dimer interface [polypeptide binding]; other site 169963000849 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963000850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963000851 putative Zn2+ binding site [ion binding]; other site 169963000852 putative DNA binding site [nucleotide binding]; other site 169963000853 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 169963000854 Zn binding site [ion binding]; other site 169963000855 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 169963000856 Zn binding site [ion binding]; other site 169963000857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963000858 catalytic core [active] 169963000859 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 169963000860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000861 dimer interface [polypeptide binding]; other site 169963000862 conserved gate region; other site 169963000863 putative PBP binding loops; other site 169963000864 ABC-ATPase subunit interface; other site 169963000865 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 169963000866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000867 dimer interface [polypeptide binding]; other site 169963000868 conserved gate region; other site 169963000869 putative PBP binding loops; other site 169963000870 ABC-ATPase subunit interface; other site 169963000871 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 169963000872 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963000873 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963000874 sugar phosphate phosphatase; Provisional; Region: PRK10513 169963000875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000876 active site 169963000877 motif I; other site 169963000878 motif II; other site 169963000879 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963000880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963000881 Coenzyme A binding pocket [chemical binding]; other site 169963000882 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 169963000884 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 169963000885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 169963000886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000887 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 169963000888 active site 169963000889 motif I; other site 169963000890 motif II; other site 169963000891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963000892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963000893 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963000894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963000895 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 169963000896 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 169963000897 Walker A/P-loop; other site 169963000898 ATP binding site [chemical binding]; other site 169963000899 Q-loop/lid; other site 169963000900 ABC transporter signature motif; other site 169963000901 Walker B; other site 169963000902 D-loop; other site 169963000903 H-loop/switch region; other site 169963000904 TOBE domain; Region: TOBE; pfam03459 169963000905 ATP cone domain; Region: ATP-cone; pfam03477 169963000906 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 169963000907 Class III ribonucleotide reductase; Region: RNR_III; cd01675 169963000908 effector binding site; other site 169963000909 active site 169963000910 Zn binding site [ion binding]; other site 169963000911 glycine loop; other site 169963000912 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 169963000913 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 169963000914 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963000915 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963000916 ligand binding site [chemical binding]; other site 169963000917 flexible hinge region; other site 169963000918 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 169963000919 putative active site [active] 169963000920 catalytic triad [active] 169963000921 putative dimer interface [polypeptide binding]; other site 169963000922 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963000923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963000924 dimer interface [polypeptide binding]; other site 169963000925 conserved gate region; other site 169963000926 putative PBP binding loops; other site 169963000927 ABC-ATPase subunit interface; other site 169963000928 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 169963000929 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 169963000930 Walker A/P-loop; other site 169963000931 ATP binding site [chemical binding]; other site 169963000932 Q-loop/lid; other site 169963000933 ABC transporter signature motif; other site 169963000934 Walker B; other site 169963000935 D-loop; other site 169963000936 H-loop/switch region; other site 169963000937 NIL domain; Region: NIL; pfam09383 169963000938 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 169963000939 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 169963000940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963000941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963000942 homodimer interface [polypeptide binding]; other site 169963000943 catalytic residue [active] 169963000944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963000945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963000946 active site 169963000947 phosphorylation site [posttranslational modification] 169963000948 intermolecular recognition site; other site 169963000949 dimerization interface [polypeptide binding]; other site 169963000950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963000951 DNA binding site [nucleotide binding] 169963000952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 169963000953 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963000954 dimerization interface [polypeptide binding]; other site 169963000955 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 169963000956 putative active site [active] 169963000957 heme pocket [chemical binding]; other site 169963000958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963000959 dimer interface [polypeptide binding]; other site 169963000960 phosphorylation site [posttranslational modification] 169963000961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963000962 ATP binding site [chemical binding]; other site 169963000963 Mg2+ binding site [ion binding]; other site 169963000964 G-X-G motif; other site 169963000965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 169963000966 YycH protein; Region: YycH; pfam07435 169963000967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 169963000968 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 169963000969 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 169963000970 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 169963000971 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 169963000972 protein binding site [polypeptide binding]; other site 169963000973 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 169963000974 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963000975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963000976 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 169963000977 dimerization interface [polypeptide binding]; other site 169963000978 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 169963000979 dimer interface [polypeptide binding]; other site 169963000980 FMN binding site [chemical binding]; other site 169963000981 NADPH bind site [chemical binding]; other site 169963000982 Protein of unknown function (DUF998); Region: DUF998; pfam06197 169963000983 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963000984 HTH domain; Region: HTH_11; pfam08279 169963000985 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963000986 PRD domain; Region: PRD; pfam00874 169963000987 PRD domain; Region: PRD; pfam00874 169963000988 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 169963000989 active site 169963000990 P-loop; other site 169963000991 phosphorylation site [posttranslational modification] 169963000992 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963000993 active site 169963000994 phosphorylation site [posttranslational modification] 169963000995 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963000996 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963000997 active site 169963000998 P-loop; other site 169963000999 phosphorylation site [posttranslational modification] 169963001000 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963001001 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963001002 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963001003 methionine cluster; other site 169963001004 active site 169963001005 phosphorylation site [posttranslational modification] 169963001006 metal binding site [ion binding]; metal-binding site 169963001007 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 169963001008 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 169963001009 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 169963001010 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 169963001011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963001012 catalytic residue [active] 169963001013 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 169963001014 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 169963001015 nucleophilic elbow; other site 169963001016 catalytic triad; other site 169963001018 Protein of unknown function DUF262; Region: DUF262; pfam03235 169963001019 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 169963001020 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 169963001021 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 169963001022 active site 169963001023 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 169963001024 putative active site [active] 169963001025 YdjC motif; other site 169963001026 Mg binding site [ion binding]; other site 169963001027 putative homodimer interface [polypeptide binding]; other site 169963001028 Putative transcription activator [Transcription]; Region: TenA; COG0819 169963001029 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 169963001030 substrate binding site [chemical binding]; other site 169963001031 multimerization interface [polypeptide binding]; other site 169963001032 ATP binding site [chemical binding]; other site 169963001033 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 169963001034 dimer interface [polypeptide binding]; other site 169963001035 substrate binding site [chemical binding]; other site 169963001036 ATP binding site [chemical binding]; other site 169963001037 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 169963001038 thiamine phosphate binding site [chemical binding]; other site 169963001039 active site 169963001040 pyrophosphate binding site [ion binding]; other site 169963001041 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963001042 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963001043 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001044 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 169963001045 Bacterial PH domain; Region: bPH_1; pfam08000 169963001046 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 169963001047 putative catalytic site [active] 169963001048 putative metal binding site [ion binding]; other site 169963001049 putative phosphate binding site [ion binding]; other site 169963001050 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963001051 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963001052 non-specific DNA binding site [nucleotide binding]; other site 169963001053 salt bridge; other site 169963001054 sequence-specific DNA binding site [nucleotide binding]; other site 169963001055 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 169963001056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963001057 non-specific DNA binding site [nucleotide binding]; other site 169963001058 salt bridge; other site 169963001059 sequence-specific DNA binding site [nucleotide binding]; other site 169963001060 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 169963001061 Leucine rich repeat; Region: LRR_8; pfam13855 169963001062 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001063 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001064 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001065 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001066 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001067 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001068 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001069 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001070 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001071 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001072 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001073 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001074 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001075 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001076 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 169963001077 putative transposase OrfB; Reviewed; Region: PHA02517 169963001078 HTH-like domain; Region: HTH_21; pfam13276 169963001079 Integrase core domain; Region: rve; pfam00665 169963001080 Integrase core domain; Region: rve_3; cl15866 169963001081 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963001082 Substrate binding site [chemical binding]; other site 169963001083 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001084 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001085 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963001086 Leucine-rich repeats; other site 169963001087 Leucine rich repeat; Region: LRR_8; pfam13855 169963001088 Substrate binding site [chemical binding]; other site 169963001089 Leucine rich repeat; Region: LRR_8; pfam13855 169963001090 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963001091 Leucine-rich repeats; other site 169963001092 Leucine rich repeat; Region: LRR_8; pfam13855 169963001093 Substrate binding site [chemical binding]; other site 169963001094 Leucine rich repeat; Region: LRR_8; pfam13855 169963001095 Leucine rich repeat; Region: LRR_8; pfam13855 169963001096 Leucine rich repeat; Region: LRR_8; pfam13855 169963001097 Leucine rich repeat; Region: LRR_8; pfam13855 169963001098 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001099 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001100 Leucine rich repeat; Region: LRR_8; pfam13855 169963001101 LRR adjacent; Region: LRR_adjacent; pfam08191 169963001102 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001103 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001104 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001105 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 169963001106 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 169963001107 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 169963001108 LXG domain of WXG superfamily; Region: LXG; pfam04740 169963001109 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 169963001110 dimer interface [polypeptide binding]; other site 169963001111 Enterocin A Immunity; Region: EntA_Immun; pfam08951 169963001112 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 169963001113 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 169963001114 TPP-binding site [chemical binding]; other site 169963001115 dimer interface [polypeptide binding]; other site 169963001116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 169963001117 PYR/PP interface [polypeptide binding]; other site 169963001118 dimer interface [polypeptide binding]; other site 169963001119 TPP binding site [chemical binding]; other site 169963001120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963001121 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 169963001122 active site 169963001123 intersubunit interactions; other site 169963001124 catalytic residue [active] 169963001125 short chain dehydrogenase; Provisional; Region: PRK06841 169963001126 classical (c) SDRs; Region: SDR_c; cd05233 169963001127 NAD(P) binding site [chemical binding]; other site 169963001128 active site 169963001129 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 169963001130 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 169963001131 substrate binding site [chemical binding]; other site 169963001132 dimer interface [polypeptide binding]; other site 169963001133 catalytic triad [active] 169963001134 DAK2 domain; Region: Dak2; cl03685 169963001135 Dak1 domain; Region: Dak1; cl10557 169963001136 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 169963001137 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 169963001138 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963001139 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 169963001140 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963001141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963001142 Coenzyme A binding pocket [chemical binding]; other site 169963001143 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 169963001144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 169963001145 acyl-activating enzyme (AAE) consensus motif; other site 169963001146 AMP binding site [chemical binding]; other site 169963001147 active site 169963001148 CoA binding site [chemical binding]; other site 169963001149 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 169963001150 L-aspartate oxidase; Provisional; Region: PRK06175 169963001151 putative oxidoreductase; Provisional; Region: PRK10206 169963001152 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963001153 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963001154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001155 active site 169963001156 phosphorylation site [posttranslational modification] 169963001157 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 169963001158 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963001159 active site 169963001160 P-loop; other site 169963001161 phosphorylation site [posttranslational modification] 169963001162 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963001163 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 169963001164 intersubunit interface [polypeptide binding]; other site 169963001165 active site 169963001166 zinc binding site [ion binding]; other site 169963001167 Na+ binding site [ion binding]; other site 169963001168 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963001169 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 169963001170 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963001171 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 169963001172 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 169963001173 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 169963001174 conserved cys residue [active] 169963001175 Predicted transcriptional regulator [Transcription]; Region: COG2378 169963001176 HTH domain; Region: HTH_11; pfam08279 169963001177 WYL domain; Region: WYL; pfam13280 169963001178 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 169963001179 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 169963001180 Imelysin; Region: Peptidase_M75; pfam09375 169963001181 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 169963001182 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 169963001183 nudix motif; other site 169963001184 hypothetical protein; Provisional; Region: PRK12378 169963001185 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 169963001186 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 169963001187 PhnA protein; Region: PhnA; pfam03831 169963001188 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963001189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963001190 DNA-binding site [nucleotide binding]; DNA binding site 169963001191 UTRA domain; Region: UTRA; pfam07702 169963001192 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963001193 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963001194 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963001195 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963001196 active site 169963001197 P-loop; other site 169963001198 phosphorylation site [posttranslational modification] 169963001199 Predicted transcriptional regulator [Transcription]; Region: COG2378 169963001200 HTH domain; Region: HTH_11; pfam08279 169963001201 WYL domain; Region: WYL; pfam13280 169963001202 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 169963001203 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963001204 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 169963001205 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963001206 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 169963001207 tetrameric interface [polypeptide binding]; other site 169963001208 NAD binding site [chemical binding]; other site 169963001209 catalytic residues [active] 169963001210 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 169963001211 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 169963001212 substrate binding site [chemical binding]; other site 169963001213 ATP binding site [chemical binding]; other site 169963001214 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 169963001215 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 169963001216 PYR/PP interface [polypeptide binding]; other site 169963001217 dimer interface [polypeptide binding]; other site 169963001218 TPP binding site [chemical binding]; other site 169963001219 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 169963001220 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 169963001221 TPP-binding site [chemical binding]; other site 169963001222 Uncharacterized conserved protein [Function unknown]; Region: COG5646 169963001223 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 169963001224 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 169963001225 ligand binding site [chemical binding]; other site 169963001226 active site 169963001227 UGI interface [polypeptide binding]; other site 169963001228 catalytic site [active] 169963001229 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 169963001230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864 169963001231 Bacterial SH3 domain; Region: SH3_3; pfam08239 169963001232 NlpC/P60 family; Region: NLPC_P60; pfam00877 169963001233 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963001234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963001235 Coenzyme A binding pocket [chemical binding]; other site 169963001236 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 169963001237 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 169963001238 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 169963001239 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 169963001240 putative hydrophobic ligand binding site [chemical binding]; other site 169963001241 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001242 active site 169963001243 phosphorylation site [posttranslational modification] 169963001244 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963001245 active site 169963001246 P-loop; other site 169963001247 phosphorylation site [posttranslational modification] 169963001248 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963001249 alpha-mannosidase; Provisional; Region: PRK09819 169963001250 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 169963001251 active site 169963001252 metal binding site [ion binding]; metal-binding site 169963001253 catalytic site [active] 169963001254 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 169963001255 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 169963001256 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963001257 HTH domain; Region: HTH_11; pfam08279 169963001258 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963001259 PRD domain; Region: PRD; pfam00874 169963001260 PRD domain; Region: PRD; pfam00874 169963001261 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963001262 active site 169963001263 P-loop; other site 169963001264 phosphorylation site [posttranslational modification] 169963001265 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001266 active site 169963001267 phosphorylation site [posttranslational modification] 169963001268 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 169963001269 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 169963001270 putative metal binding site [ion binding]; other site 169963001271 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 169963001272 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 169963001273 trimer interface [polypeptide binding]; other site 169963001274 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963001275 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963001276 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963001277 Leucine-rich repeats; other site 169963001278 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001279 Substrate binding site [chemical binding]; other site 169963001280 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001281 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001282 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001283 LRR adjacent; Region: LRR_adjacent; pfam08191 169963001284 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001285 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001286 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001287 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001288 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001289 phosphoenolpyruvate synthase, C-terminal 169963001290 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 169963001291 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 169963001292 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 169963001293 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 169963001294 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 169963001295 NodB motif; other site 169963001296 active site 169963001297 catalytic site [active] 169963001298 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963001299 non-specific DNA binding site [nucleotide binding]; other site 169963001300 salt bridge; other site 169963001301 sequence-specific DNA binding site [nucleotide binding]; other site 169963001302 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 169963001303 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963001304 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963001305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963001306 active site 169963001307 motif I; other site 169963001308 motif II; other site 169963001309 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 169963001310 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 169963001311 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 169963001312 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 169963001313 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 169963001314 DNA binding residues [nucleotide binding] 169963001315 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 169963001316 Sugar transport protein; Region: Sugar_transport; pfam06800 169963001317 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963001318 HTH domain; Region: HTH_11; pfam08279 169963001319 PRD domain; Region: PRD; pfam00874 169963001320 PRD domain; Region: PRD; pfam00874 169963001321 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963001322 active site 169963001323 P-loop; other site 169963001324 phosphorylation site [posttranslational modification] 169963001325 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 169963001326 active site 169963001327 phosphorylation site [posttranslational modification] 169963001328 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001329 active site 169963001330 phosphorylation site [posttranslational modification] 169963001331 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963001332 active site 169963001333 P-loop; other site 169963001334 phosphorylation site [posttranslational modification] 169963001335 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963001336 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 169963001337 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 169963001338 active site 169963001339 metal binding site [ion binding]; metal-binding site 169963001340 catalytic site [active] 169963001341 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 169963001342 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 169963001343 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963001344 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963001345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 169963001346 dimerization interface [polypeptide binding]; other site 169963001347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 169963001348 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 169963001349 putative trimer interface [polypeptide binding]; other site 169963001350 putative CoA binding site [chemical binding]; other site 169963001351 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 169963001352 classical (c) SDRs; Region: SDR_c; cd05233 169963001353 NAD(P) binding site [chemical binding]; other site 169963001354 active site 169963001355 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963001356 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001357 Leucine rich repeat; Region: LRR_8; pfam13855 169963001358 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001359 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963001360 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963001361 Leucine-rich repeats; other site 169963001362 Substrate binding site [chemical binding]; other site 169963001363 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001364 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001365 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001366 LRR adjacent; Region: LRR_adjacent; pfam08191 169963001367 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001368 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001369 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001370 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963001371 Leucine rich repeat; Region: LRR_8; pfam13855 169963001372 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001373 Leucine rich repeat; Region: LRR_8; pfam13855 169963001374 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001376 LRR adjacent; Region: LRR_adjacent; pfam08191 169963001377 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 169963001378 SH3-like domain; Region: SH3_8; pfam13457 169963001379 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 169963001380 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963001381 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001382 Rrf2 family protein; Region: rrf2_super; TIGR00738 169963001383 Predicted transcriptional regulator [Transcription]; Region: COG1959 169963001384 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 169963001385 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 169963001386 NADP binding site [chemical binding]; other site 169963001387 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 169963001388 Condensation domain; Region: Condensation; cl19241 169963001389 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 169963001390 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 169963001391 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 169963001392 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 169963001393 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 169963001394 Transcriptional regulator [Transcription]; Region: LytR; COG1316 169963001395 Predicted membrane protein [Function unknown]; Region: COG1511 169963001396 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 169963001397 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 169963001398 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 169963001399 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963001400 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 169963001401 active site 169963001402 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 169963001403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963001404 catalytic residue [active] 169963001405 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 169963001406 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 169963001407 Predicted membrane protein [Function unknown]; Region: COG3619 169963001408 Acyltransferase family; Region: Acyl_transf_3; cl19154 169963001409 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 169963001410 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 169963001411 Surface protein; Region: DUF3664; pfam12406 169963001412 Mucin-like glycoprotein; Region: Mucin; pfam01456 169963001413 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 169963001414 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 169963001415 Protein of unknown function DUF58; Region: DUF58; pfam01882 169963001416 MoxR-like ATPases [General function prediction only]; Region: COG0714 169963001417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963001418 Walker A motif; other site 169963001419 ATP binding site [chemical binding]; other site 169963001420 Walker B motif; other site 169963001421 arginine finger; other site 169963001422 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 169963001423 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 169963001424 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 169963001425 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 169963001426 Na binding site [ion binding]; other site 169963001427 Uncharacterized conserved protein [Function unknown]; Region: COG3535 169963001428 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 169963001429 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 169963001430 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963001431 nucleotide binding site [chemical binding]; other site 169963001432 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 169963001433 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963001434 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 169963001435 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001436 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001437 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 169963001438 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001439 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001440 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001441 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001442 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001443 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 169963001444 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 169963001445 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001446 Helix-turn-helix domain; Region: HTH_17; pfam12728 169963001447 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 169963001448 AP2 domain; Region: AP2; pfam00847 169963001449 DNA methylase; Region: N6_N4_Mtase; pfam01555 169963001450 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 169963001451 LXG domain of WXG superfamily; Region: LXG; pfam04740 169963001452 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963001453 Zn2+ binding site [ion binding]; other site 169963001454 Mg2+ binding site [ion binding]; other site 169963001455 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 169963001456 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 169963001457 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 169963001458 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 169963001459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963001460 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 169963001461 Myosin-crossreactive antigen [Function unknown]; Region: COG4716 169963001462 myosin-cross-reactive antigen; Provisional; Region: PRK13977 169963001463 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 169963001464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 169963001465 FeS/SAM binding site; other site 169963001466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 169963001467 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 169963001468 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 169963001469 putative FMN binding site [chemical binding]; other site 169963001470 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 169963001471 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 169963001472 nudix motif; other site 169963001473 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963001474 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963001475 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 169963001476 putative dimerization interface [polypeptide binding]; other site 169963001477 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 169963001478 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 169963001479 active site 169963001480 FMN binding site [chemical binding]; other site 169963001481 substrate binding site [chemical binding]; other site 169963001482 putative catalytic residue [active] 169963001483 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963001484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963001485 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 169963001486 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 169963001487 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 169963001488 shikimate binding site; other site 169963001489 NAD(P) binding site [chemical binding]; other site 169963001490 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 169963001491 active site 169963001492 catalytic residue [active] 169963001493 dimer interface [polypeptide binding]; other site 169963001494 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963001495 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963001496 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 169963001497 dimerization interface [polypeptide binding]; other site 169963001498 Predicted acyl esterases [General function prediction only]; Region: COG2936 169963001499 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 169963001500 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 169963001501 active site 169963001502 catalytic triad [active] 169963001503 oxyanion hole [active] 169963001504 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 169963001505 EamA-like transporter family; Region: EamA; pfam00892 169963001506 EamA-like transporter family; Region: EamA; pfam00892 169963001507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 169963001508 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 169963001509 active site 169963001510 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 169963001511 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963001512 substrate binding site [chemical binding]; other site 169963001513 hexamer interface [polypeptide binding]; other site 169963001514 metal binding site [ion binding]; metal-binding site 169963001515 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 169963001516 catalytic residue [active] 169963001517 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963001518 PRD domain; Region: PRD; pfam00874 169963001519 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963001520 active site 169963001521 P-loop; other site 169963001522 phosphorylation site [posttranslational modification] 169963001523 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001524 active site 169963001525 phosphorylation site [posttranslational modification] 169963001526 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 169963001527 putative active site [active] 169963001528 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001529 active site 169963001530 phosphorylation site [posttranslational modification] 169963001531 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963001532 substrate binding site [chemical binding]; other site 169963001533 hexamer interface [polypeptide binding]; other site 169963001534 metal binding site [ion binding]; metal-binding site 169963001535 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 169963001536 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 169963001537 putative NAD(P) binding site [chemical binding]; other site 169963001538 catalytic Zn binding site [ion binding]; other site 169963001539 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 169963001540 active site 169963001541 P-loop; other site 169963001542 phosphorylation site [posttranslational modification] 169963001543 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 169963001544 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 169963001545 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 169963001546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963001547 active site 169963001548 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 169963001549 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 169963001550 catalytic triad [active] 169963001551 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 169963001552 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963001553 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963001554 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001555 Leucine rich repeat; Region: LRR_8; pfam13855 169963001556 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001557 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 169963001559 Ligand Binding Site [chemical binding]; other site 169963001560 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 169963001561 putative active site [active] 169963001562 putative metal binding site [ion binding]; other site 169963001563 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963001564 catalytic core [active] 169963001565 Predicted membrane protein [Function unknown]; Region: COG3759 169963001566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963001567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963001568 putative substrate translocation pore; other site 169963001569 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 169963001570 non-specific DNA interactions [nucleotide binding]; other site 169963001571 DNA binding site [nucleotide binding] 169963001572 sequence specific DNA binding site [nucleotide binding]; other site 169963001573 putative cAMP binding site [chemical binding]; other site 169963001574 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963001575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963001576 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 169963001577 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 169963001578 NAD binding site [chemical binding]; other site 169963001579 sugar binding site [chemical binding]; other site 169963001580 divalent metal binding site [ion binding]; other site 169963001581 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963001582 dimer interface [polypeptide binding]; other site 169963001583 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963001584 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963001585 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963001586 putative active site [active] 169963001587 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 169963001588 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 169963001589 Sulfate transporter family; Region: Sulfate_transp; pfam00916 169963001590 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 169963001591 Uncharacterized conserved protein [Function unknown]; Region: COG5361 169963001592 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 169963001593 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 169963001594 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 169963001595 DNA binding residues [nucleotide binding] 169963001596 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 169963001597 dimer interface [polypeptide binding]; other site 169963001598 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 169963001599 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 169963001600 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 169963001601 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 169963001602 DXD motif; other site 169963001603 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 169963001604 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 169963001605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963001606 S-adenosylmethionine binding site [chemical binding]; other site 169963001607 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 169963001608 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 169963001609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963001610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963001611 DNA binding site [nucleotide binding] 169963001612 domain linker motif; other site 169963001613 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 169963001614 putative dimerization interface [polypeptide binding]; other site 169963001615 putative ligand binding site [chemical binding]; other site 169963001616 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 169963001617 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 169963001618 NAD binding site [chemical binding]; other site 169963001619 sugar binding site [chemical binding]; other site 169963001620 divalent metal binding site [ion binding]; other site 169963001621 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963001622 dimer interface [polypeptide binding]; other site 169963001623 allantoate amidohydrolase; Reviewed; Region: PRK09290 169963001624 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 169963001625 active site 169963001626 metal binding site [ion binding]; metal-binding site 169963001627 dimer interface [polypeptide binding]; other site 169963001628 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 169963001629 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 169963001630 metal binding site [ion binding]; metal-binding site 169963001631 putative dimer interface [polypeptide binding]; other site 169963001632 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 169963001633 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 169963001634 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 169963001635 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 169963001636 intersubunit interface [polypeptide binding]; other site 169963001637 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 169963001638 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 169963001639 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 169963001640 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 169963001641 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 169963001642 Glucitol operon activator protein (GutM); Region: GutM; cl01890 169963001643 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 169963001644 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 169963001645 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 169963001646 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 169963001647 Homeodomain-like domain; Region: HTH_23; pfam13384 169963001648 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 169963001649 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963001650 Leucine rich repeat; Region: LRR_8; pfam13855 169963001651 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001652 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001653 Leucine rich repeat; Region: LRR_8; pfam13855 169963001654 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001655 WxL domain surface cell wall-binding; Region: WxL; pfam13731 169963001656 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001657 WxL domain surface cell wall-binding; Region: WxL; pfam13731 169963001658 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 169963001659 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 169963001660 FOG: CBS domain [General function prediction only]; Region: COG0517 169963001661 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 169963001662 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 169963001663 dimer interface [polypeptide binding]; other site 169963001664 active site 169963001665 metal binding site [ion binding]; metal-binding site 169963001666 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 169963001667 POT family; Region: PTR2; cl17359 169963001668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963001669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963001670 catalytic core [active] 169963001671 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963001672 catalytic core [active] 169963001673 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 169963001674 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 169963001675 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 169963001676 Cl binding site [ion binding]; other site 169963001677 oligomer interface [polypeptide binding]; other site 169963001678 glutamate dehydrogenase; Provisional; Region: PRK09414 169963001679 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 169963001680 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 169963001681 NAD(P) binding site [chemical binding]; other site 169963001682 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 169963001683 metal binding site [ion binding]; metal-binding site 169963001684 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 169963001685 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 169963001686 substrate binding site [chemical binding]; other site 169963001687 glutamase interaction surface [polypeptide binding]; other site 169963001688 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 169963001689 catalytic residues [active] 169963001690 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 169963001691 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 169963001692 putative active site [active] 169963001693 oxyanion strand; other site 169963001694 catalytic triad [active] 169963001695 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 169963001696 putative active site pocket [active] 169963001697 4-fold oligomerization interface [polypeptide binding]; other site 169963001698 metal binding residues [ion binding]; metal-binding site 169963001699 3-fold/trimer interface [polypeptide binding]; other site 169963001700 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 169963001701 histidinol dehydrogenase; Region: hisD; TIGR00069 169963001702 NAD binding site [chemical binding]; other site 169963001703 dimerization interface [polypeptide binding]; other site 169963001704 product binding site; other site 169963001705 substrate binding site [chemical binding]; other site 169963001706 zinc binding site [ion binding]; other site 169963001707 catalytic residues [active] 169963001708 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 169963001709 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 169963001710 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 169963001711 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 169963001712 dimer interface [polypeptide binding]; other site 169963001713 motif 1; other site 169963001714 active site 169963001715 motif 2; other site 169963001716 motif 3; other site 169963001717 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 169963001718 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 169963001719 active site 169963001720 dimer interface [polypeptide binding]; other site 169963001721 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 169963001722 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 169963001723 DNA binding site [nucleotide binding] 169963001724 active site 169963001725 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 169963001726 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 169963001727 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963001728 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963001729 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963001730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 169963001731 DNA-binding site [nucleotide binding]; DNA binding site 169963001732 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 169963001733 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001734 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963001735 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 169963001736 Uncharacterized conserved protein [Function unknown]; Region: COG2966 169963001737 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 169963001738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 169963001739 Predicted esterase [General function prediction only]; Region: COG0400 169963001740 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963001741 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 169963001742 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 169963001743 putative RNA binding site [nucleotide binding]; other site 169963001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963001745 S-adenosylmethionine binding site [chemical binding]; other site 169963001746 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 169963001747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963001748 Bacterial SH3 domain homologues; Region: SH3b; smart00287 169963001749 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963001750 NlpC/P60 family; Region: NLPC_P60; pfam00877 169963001751 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 169963001752 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963001753 ATP binding site [chemical binding]; other site 169963001754 putative Mg++ binding site [ion binding]; other site 169963001755 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 169963001756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963001757 nucleotide binding region [chemical binding]; other site 169963001758 ATP-binding site [chemical binding]; other site 169963001759 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 169963001760 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 169963001761 WxL domain surface cell wall-binding; Region: WxL; pfam13731 169963001762 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 169963001763 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 169963001764 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 169963001765 DNA photolyase; Region: DNA_photolyase; pfam00875 169963001766 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 169963001767 Predicted membrane protein [Function unknown]; Region: COG4852 169963001768 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 169963001769 DAK2 domain; Region: Dak2; pfam02734 169963001770 EDD domain protein, DegV family; Region: DegV; TIGR00762 169963001771 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 169963001772 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 169963001773 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 169963001774 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 169963001775 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 169963001776 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 169963001777 homodimer interface [polypeptide binding]; other site 169963001778 substrate-cofactor binding pocket; other site 169963001779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963001780 catalytic residue [active] 169963001781 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 169963001782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963001783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 169963001784 ligand binding site [chemical binding]; other site 169963001785 flexible hinge region; other site 169963001786 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963001787 non-specific DNA interactions [nucleotide binding]; other site 169963001788 DNA binding site [nucleotide binding] 169963001789 sequence specific DNA binding site [nucleotide binding]; other site 169963001790 putative cAMP binding site [chemical binding]; other site 169963001791 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 169963001792 Predicted transcriptional regulators [Transcription]; Region: COG1695 169963001793 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963001794 putative Zn2+ binding site [ion binding]; other site 169963001795 putative DNA binding site [nucleotide binding]; other site 169963001796 Predicted membrane protein [Function unknown]; Region: COG4709 169963001797 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 169963001798 Uncharacterized conserved protein [Function unknown]; Region: COG3595 169963001799 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 169963001800 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 169963001801 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 169963001802 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963001803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963001804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963001805 Coenzyme A binding pocket [chemical binding]; other site 169963001806 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 169963001807 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 169963001808 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963001809 putative DNA binding site [nucleotide binding]; other site 169963001810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963001811 putative Zn2+ binding site [ion binding]; other site 169963001812 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963001813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963001814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963001815 Walker A/P-loop; other site 169963001816 ATP binding site [chemical binding]; other site 169963001817 Q-loop/lid; other site 169963001818 ABC transporter signature motif; other site 169963001819 Walker B; other site 169963001820 D-loop; other site 169963001821 H-loop/switch region; other site 169963001822 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963001823 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963001824 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 169963001825 Walker A/P-loop; other site 169963001826 ATP binding site [chemical binding]; other site 169963001827 Q-loop/lid; other site 169963001828 ABC transporter signature motif; other site 169963001829 Walker B; other site 169963001830 D-loop; other site 169963001831 H-loop/switch region; other site 169963001832 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 169963001833 active site residue [active] 169963001834 Antagonist of mitotic exit network protein 1; Region: AMN1; cd09293 169963001835 Leucine rich repeat; Region: LRR_8; pfam13855 169963001836 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963001837 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963001838 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 169963001839 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963001840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963001841 putative DNA binding site [nucleotide binding]; other site 169963001842 putative Zn2+ binding site [ion binding]; other site 169963001843 MarR family; Region: MarR_2; cl17246 169963001844 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 169963001845 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 169963001846 putative NAD(P) binding site [chemical binding]; other site 169963001847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963001848 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 169963001849 Coenzyme A binding pocket [chemical binding]; other site 169963001850 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963001851 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 169963001852 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 169963001853 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 169963001854 putative active site [active] 169963001855 catalytic site [active] 169963001856 putative metal binding site [ion binding]; other site 169963001857 Catalytic domain of Protein Kinases; Region: PKc; cd00180 169963001858 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 169963001859 active site 169963001860 ATP binding site [chemical binding]; other site 169963001861 substrate binding site [chemical binding]; other site 169963001862 activation loop (A-loop); other site 169963001863 Helix-turn-helix domain; Region: HTH_31; pfam13560 169963001864 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 169963001865 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 169963001866 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 169963001867 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963001869 Coenzyme A binding pocket [chemical binding]; other site 169963001870 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 169963001871 active site 169963001872 catalytic triad [active] 169963001873 oxyanion hole [active] 169963001874 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 169963001875 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 169963001876 domain interaction interfaces [polypeptide binding]; other site 169963001877 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 169963001878 domain interaction interfaces [polypeptide binding]; other site 169963001879 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 169963001880 domain interaction interfaces [polypeptide binding]; other site 169963001881 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 169963001882 domain interaction interfaces [polypeptide binding]; other site 169963001883 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 169963001884 catalytic triad [active] 169963001885 conserved cis-peptide bond; other site 169963001886 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963001887 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963001888 PRD domain; Region: PRD; pfam00874 169963001889 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 169963001890 active site 169963001891 P-loop; other site 169963001892 phosphorylation site [posttranslational modification] 169963001893 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 169963001894 active site 169963001895 phosphorylation site [posttranslational modification] 169963001896 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963001897 active site 169963001898 phosphorylation site [posttranslational modification] 169963001899 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 169963001900 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963001901 active site 169963001902 P-loop; other site 169963001903 phosphorylation site [posttranslational modification] 169963001904 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 169963001905 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 169963001906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963001907 motif II; other site 169963001908 Predicted transcriptional regulator [Transcription]; Region: COG1959 169963001909 Rrf2 family protein; Region: rrf2_super; TIGR00738 169963001910 Methyltransferase domain; Region: Methyltransf_31; pfam13847 169963001911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963001912 S-adenosylmethionine binding site [chemical binding]; other site 169963001913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 169963001914 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 169963001915 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963001916 active site 169963001917 catalytic tetrad [active] 169963001918 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 169963001919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963001920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963001921 motif II; other site 169963001922 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 169963001923 catalytic residue [active] 169963001924 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 169963001925 Sulfatase; Region: Sulfatase; pfam00884 169963001926 amino acid transporter; Region: 2A0306; TIGR00909 169963001927 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963001928 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 169963001929 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 169963001930 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 169963001931 putative metal binding site [ion binding]; other site 169963001932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 169963001933 active site 169963001934 metal binding site [ion binding]; metal-binding site 169963001935 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 169963001936 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 169963001937 Cl binding site [ion binding]; other site 169963001938 oligomer interface [polypeptide binding]; other site 169963001939 Transcriptional regulators [Transcription]; Region: GntR; COG1802 169963001940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 169963001941 DNA-binding site [nucleotide binding]; DNA binding site 169963001942 Predicted membrane protein [Function unknown]; Region: COG1511 169963001943 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 169963001944 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 169963001945 Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488 169963001946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963001947 Transcriptional regulators [Transcription]; Region: FadR; COG2186 169963001948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963001949 DNA-binding site [nucleotide binding]; DNA binding site 169963001950 FCD domain; Region: FCD; pfam07729 169963001951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 169963001952 Predicted integral membrane protein [Function unknown]; Region: COG5523 169963001953 putative protein phosphatase; Region: PHA02239 169963001954 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 169963001955 active site 169963001956 metal binding site [ion binding]; metal-binding site 169963001957 Predicted membrane protein [Function unknown]; Region: COG2322 169963001958 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 169963001959 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 169963001960 minor groove reading motif; other site 169963001961 helix-hairpin-helix signature motif; other site 169963001962 substrate binding pocket [chemical binding]; other site 169963001963 active site 169963001964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963001965 non-specific DNA binding site [nucleotide binding]; other site 169963001966 salt bridge; other site 169963001967 sequence-specific DNA binding site [nucleotide binding]; other site 169963001968 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 169963001969 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 169963001970 Transposase; Region: HTH_Tnp_1; cl17663 169963001971 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 169963001972 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 169963001973 dimer interface [polypeptide binding]; other site 169963001974 substrate binding site [chemical binding]; other site 169963001975 ATP binding site [chemical binding]; other site 169963001976 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963001977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963001978 active site 169963001979 motif I; other site 169963001980 motif II; other site 169963001981 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963001982 maltose O-acetyltransferase; Provisional; Region: PRK10092 169963001983 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 169963001984 active site 169963001985 substrate binding site [chemical binding]; other site 169963001986 trimer interface [polypeptide binding]; other site 169963001987 CoA binding site [chemical binding]; other site 169963001988 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 169963001989 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963001990 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963001991 Walker A/P-loop; other site 169963001992 ATP binding site [chemical binding]; other site 169963001993 Q-loop/lid; other site 169963001994 ABC transporter signature motif; other site 169963001995 Walker B; other site 169963001996 D-loop; other site 169963001997 H-loop/switch region; other site 169963001998 inner membrane transport permease; Provisional; Region: PRK15066 169963001999 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 169963002000 oxidoreductase; Provisional; Region: PRK07985 169963002001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 169963002002 NAD(P) binding site [chemical binding]; other site 169963002003 active site 169963002004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 169963002005 Predicted membrane protein [Function unknown]; Region: COG3152 169963002006 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 169963002007 Organic solute transporter subunit beta protein; Region: OSTbeta; pfam15048 169963002008 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 169963002009 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 169963002010 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 169963002011 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 169963002012 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 169963002013 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 169963002014 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 169963002015 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 169963002016 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 169963002017 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 169963002018 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 169963002019 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 169963002020 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 169963002021 flagellar motor protein MotA; Validated; Region: PRK08124 169963002022 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 169963002023 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 169963002024 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 169963002025 ligand binding site [chemical binding]; other site 169963002026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 169963002027 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 169963002028 putative metal binding site; other site 169963002029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963002030 binding surface 169963002031 TPR motif; other site 169963002032 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 169963002033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963002034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963002035 active site 169963002036 phosphorylation site [posttranslational modification] 169963002037 intermolecular recognition site; other site 169963002038 dimerization interface [polypeptide binding]; other site 169963002039 flagellin; Provisional; Region: PRK12805 169963002040 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 169963002041 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 169963002042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963002043 active site 169963002044 phosphorylation site [posttranslational modification] 169963002045 intermolecular recognition site; other site 169963002046 dimerization interface [polypeptide binding]; other site 169963002047 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 169963002048 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 169963002049 putative binding surface; other site 169963002050 active site 169963002051 P2 response regulator binding domain; Region: P2; pfam07194 169963002052 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 169963002053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963002054 ATP binding site [chemical binding]; other site 169963002055 Mg2+ binding site [ion binding]; other site 169963002056 G-X-G motif; other site 169963002057 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 169963002058 flagellar motor switch protein; Validated; Region: PRK06788 169963002059 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 169963002060 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 169963002061 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 169963002062 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 169963002063 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 169963002064 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 169963002065 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 169963002066 flagellar motor switch protein; Validated; Region: PRK06789 169963002067 Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868 169963002068 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 169963002069 flagellar motor switch protein; Reviewed; Region: PRK06782 169963002070 CheC-like family; Region: CheC; pfam04509 169963002071 CheC-like family; Region: CheC; pfam04509 169963002072 Chemotaxis phosphatase CheX; Region: CheX; cl15816 169963002073 CheC-like family; Region: CheC; pfam04509 169963002074 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 169963002075 Protein of unknown function (DUF327); Region: DUF327; pfam03885 169963002076 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 169963002077 glycoprotein BALF4; Provisional; Region: PHA03231 169963002078 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 169963002079 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 169963002080 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 169963002081 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 169963002082 flagellar capping protein; Validated; Region: fliD; PRK06798 169963002083 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 169963002084 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 169963002085 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 169963002086 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 169963002087 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 169963002088 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 169963002089 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 169963002090 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 169963002091 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 169963002092 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 169963002093 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 169963002094 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 169963002095 FliG N-terminal domain; Region: FliG_N; pfam14842 169963002096 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 169963002097 FliG middle domain; Region: FliG_M; pfam14841 169963002098 FliG C-terminal domain; Region: FliG_C; pfam01706 169963002099 flagellar assembly protein H; Validated; Region: fliH; PRK06800 169963002100 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 169963002101 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 169963002102 Walker A motif; other site 169963002103 ATP binding site [chemical binding]; other site 169963002104 Walker B motif; other site 169963002105 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 169963002106 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 169963002107 N-acetyl-D-glucosamine binding site [chemical binding]; other site 169963002108 catalytic residue [active] 169963002109 Predicted transcriptional regulators [Transcription]; Region: COG1695 169963002110 putative Zn2+ binding site [ion binding]; other site 169963002111 putative DNA binding site [nucleotide binding]; other site 169963002112 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 169963002113 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 169963002114 pyruvate oxidase; Provisional; Region: PRK08611 169963002115 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 169963002116 PYR/PP interface [polypeptide binding]; other site 169963002117 dimer interface [polypeptide binding]; other site 169963002118 tetramer interface [polypeptide binding]; other site 169963002119 TPP binding site [chemical binding]; other site 169963002120 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 169963002121 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 169963002122 TPP-binding site [chemical binding]; other site 169963002123 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 169963002124 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 169963002125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963002126 dimerization interface [polypeptide binding]; other site 169963002127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 169963002128 dimer interface [polypeptide binding]; other site 169963002129 putative CheW interface [polypeptide binding]; other site 169963002130 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 169963002131 putative active site [active] 169963002132 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 169963002133 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 169963002134 glutaminase active site [active] 169963002135 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 169963002136 dimer interface [polypeptide binding]; other site 169963002137 active site 169963002138 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 169963002139 dimer interface [polypeptide binding]; other site 169963002140 active site 169963002141 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 169963002142 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 169963002143 active site 169963002144 Riboflavin kinase; Region: Flavokinase; cl03312 169963002145 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 169963002146 GIY-YIG motif/motif A; other site 169963002147 IncA protein; Region: IncA; pfam04156 169963002148 Leucine rich repeat; Region: LRR_8; pfam13855 169963002149 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002150 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963002151 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963002152 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002153 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963002154 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963002155 non-specific DNA binding site [nucleotide binding]; other site 169963002156 salt bridge; other site 169963002157 sequence-specific DNA binding site [nucleotide binding]; other site 169963002158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963002159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963002160 DNA binding site [nucleotide binding] 169963002161 domain linker motif; other site 169963002162 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963002163 ligand binding site [chemical binding]; other site 169963002164 dimerization interface [polypeptide binding]; other site 169963002165 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963002166 substrate binding site [chemical binding]; other site 169963002167 hexamer interface [polypeptide binding]; other site 169963002168 metal binding site [ion binding]; metal-binding site 169963002169 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 169963002170 BtpA family; Region: BtpA; cl00440 169963002171 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 169963002172 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 169963002173 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963002174 active site turn [active] 169963002175 phosphorylation site [posttranslational modification] 169963002176 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963002177 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 169963002178 HPr interaction site; other site 169963002179 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963002180 active site 169963002181 phosphorylation site [posttranslational modification] 169963002182 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963002183 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963002184 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963002185 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963002186 ligand binding site [chemical binding]; other site 169963002187 flexible hinge region; other site 169963002188 Predicted transcriptional regulators [Transcription]; Region: COG1725 169963002189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002190 DNA-binding site [nucleotide binding]; DNA binding site 169963002191 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 169963002192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963002193 Walker A/P-loop; other site 169963002194 ATP binding site [chemical binding]; other site 169963002195 Q-loop/lid; other site 169963002196 ABC transporter signature motif; other site 169963002197 Walker B; other site 169963002198 D-loop; other site 169963002199 H-loop/switch region; other site 169963002200 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963002201 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963002202 Walker A/P-loop; other site 169963002203 ATP binding site [chemical binding]; other site 169963002204 Q-loop/lid; other site 169963002205 ABC transporter signature motif; other site 169963002206 Walker B; other site 169963002207 D-loop; other site 169963002208 H-loop/switch region; other site 169963002209 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963002210 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963002211 FtsX-like permease family; Region: FtsX; pfam02687 169963002212 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963002213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963002214 non-specific DNA binding site [nucleotide binding]; other site 169963002215 salt bridge; other site 169963002216 sequence-specific DNA binding site [nucleotide binding]; other site 169963002217 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 169963002218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963002219 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 169963002220 ligand binding site [chemical binding]; other site 169963002221 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963002222 non-specific DNA interactions [nucleotide binding]; other site 169963002223 DNA binding site [nucleotide binding] 169963002224 sequence specific DNA binding site [nucleotide binding]; other site 169963002225 putative cAMP binding site [chemical binding]; other site 169963002226 SnoaL-like domain; Region: SnoaL_4; pfam13577 169963002227 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 169963002228 active site 169963002229 catalytic triad [active] 169963002230 oxyanion hole [active] 169963002231 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963002232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963002233 Walker A/P-loop; other site 169963002234 ATP binding site [chemical binding]; other site 169963002235 Q-loop/lid; other site 169963002236 ABC transporter signature motif; other site 169963002237 Walker B; other site 169963002238 D-loop; other site 169963002239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 169963002240 H-loop/switch region; other site 169963002241 active site 169963002242 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 169963002243 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 169963002244 Zn binding site [ion binding]; other site 169963002245 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 169963002246 Zn binding site [ion binding]; other site 169963002247 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 169963002248 Zn binding site [ion binding]; other site 169963002249 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 169963002250 Zn binding site [ion binding]; other site 169963002251 Predicted esterase [General function prediction only]; Region: COG0400 169963002252 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963002253 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 169963002254 GTPases [General function prediction only]; Region: HflX; COG2262 169963002255 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 169963002256 HflX GTPase family; Region: HflX; cd01878 169963002257 G1 box; other site 169963002258 GTP/Mg2+ binding site [chemical binding]; other site 169963002259 Switch I region; other site 169963002260 G2 box; other site 169963002261 G3 box; other site 169963002262 Switch II region; other site 169963002263 G4 box; other site 169963002264 G5 box; other site 169963002265 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 169963002266 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 169963002267 putative active site [active] 169963002268 putative metal binding site [ion binding]; other site 169963002269 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 169963002270 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 169963002271 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 169963002272 Uncharacterized conserved protein [Function unknown]; Region: COG3538 169963002273 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 169963002274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002275 dimer interface [polypeptide binding]; other site 169963002276 conserved gate region; other site 169963002277 putative PBP binding loops; other site 169963002278 ABC-ATPase subunit interface; other site 169963002279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963002280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002281 dimer interface [polypeptide binding]; other site 169963002282 conserved gate region; other site 169963002283 putative PBP binding loops; other site 169963002284 ABC-ATPase subunit interface; other site 169963002285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963002286 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 169963002287 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 169963002288 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963002289 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002290 DNA-binding site [nucleotide binding]; DNA binding site 169963002291 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 169963002292 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963002293 ligand binding site [chemical binding]; other site 169963002294 dimerization interface [polypeptide binding]; other site 169963002295 Transcriptional regulators [Transcription]; Region: GntR; COG1802 169963002296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002297 DNA-binding site [nucleotide binding]; DNA binding site 169963002298 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 169963002299 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 169963002300 putative NADP binding site [chemical binding]; other site 169963002301 putative dimer interface [polypeptide binding]; other site 169963002302 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 169963002303 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 169963002304 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963002305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963002306 nucleotide binding site [chemical binding]; other site 169963002307 Predicted membrane protein [Function unknown]; Region: COG4811 169963002308 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 169963002309 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 169963002310 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 169963002311 active site 169963002312 phosphorylation site [posttranslational modification] 169963002313 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963002314 active pocket/dimerization site; other site 169963002315 active site 169963002316 phosphorylation site [posttranslational modification] 169963002317 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 169963002318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963002319 Walker A motif; other site 169963002320 ATP binding site [chemical binding]; other site 169963002321 Walker B motif; other site 169963002322 arginine finger; other site 169963002323 Transcriptional antiterminator [Transcription]; Region: COG3933 169963002324 PRD domain; Region: PRD; pfam00874 169963002325 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963002326 active pocket/dimerization site; other site 169963002327 active site 169963002328 phosphorylation site [posttranslational modification] 169963002329 PRD domain; Region: PRD; pfam00874 169963002330 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 169963002331 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 169963002332 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963002333 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 169963002334 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 169963002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 169963002336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 169963002337 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 169963002338 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 169963002339 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 169963002340 putative deacylase active site [active] 169963002341 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 169963002342 active site 169963002343 catalytic triad [active] 169963002344 dimer interface [polypeptide binding]; other site 169963002345 Protein of unknown function (DUF554); Region: DUF554; pfam04474 169963002346 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 169963002347 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 169963002348 NAD binding site [chemical binding]; other site 169963002349 substrate binding site [chemical binding]; other site 169963002350 putative active site [active] 169963002351 Predicted permeases [General function prediction only]; Region: RarD; COG2962 169963002352 EamA-like transporter family; Region: EamA; pfam00892 169963002353 Uncharacterized conserved protein [Function unknown]; Region: COG2353 169963002354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963002355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963002356 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963002357 lysine transporter; Provisional; Region: PRK10836 169963002358 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 169963002359 PAS domain; Region: PAS_9; pfam13426 169963002360 putative active site [active] 169963002361 heme pocket [chemical binding]; other site 169963002362 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963002363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 169963002364 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963002365 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963002366 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002367 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002368 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002369 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002370 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002371 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963002372 LRR adjacent; Region: LRR_adjacent; pfam08191 169963002373 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963002374 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963002375 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 169963002376 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 169963002377 synthetase active site [active] 169963002378 NTP binding site [chemical binding]; other site 169963002379 metal binding site [ion binding]; metal-binding site 169963002380 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 169963002381 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 169963002382 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963002383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963002384 non-specific DNA binding site [nucleotide binding]; other site 169963002385 salt bridge; other site 169963002386 sequence-specific DNA binding site [nucleotide binding]; other site 169963002387 Cupin domain; Region: Cupin_2; pfam07883 169963002388 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 169963002389 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 169963002390 Walker A/P-loop; other site 169963002391 ATP binding site [chemical binding]; other site 169963002392 Q-loop/lid; other site 169963002393 ABC transporter signature motif; other site 169963002394 Walker B; other site 169963002395 D-loop; other site 169963002396 H-loop/switch region; other site 169963002397 TOBE domain; Region: TOBE_2; pfam08402 169963002398 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 169963002399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002400 dimer interface [polypeptide binding]; other site 169963002401 conserved gate region; other site 169963002402 putative PBP binding loops; other site 169963002403 ABC-ATPase subunit interface; other site 169963002404 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 169963002405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002406 dimer interface [polypeptide binding]; other site 169963002407 conserved gate region; other site 169963002408 putative PBP binding loops; other site 169963002409 ABC-ATPase subunit interface; other site 169963002410 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 169963002411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963002412 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 169963002413 active site 169963002414 zinc binding site [ion binding]; other site 169963002415 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 169963002416 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963002417 Zn2+ binding site [ion binding]; other site 169963002418 Mg2+ binding site [ion binding]; other site 169963002419 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963002420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963002421 nucleotide binding site [chemical binding]; other site 169963002422 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 169963002423 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 169963002424 FMN binding site [chemical binding]; other site 169963002425 substrate binding site [chemical binding]; other site 169963002426 putative catalytic residue [active] 169963002427 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963002428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963002429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963002430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963002431 Coenzyme A binding pocket [chemical binding]; other site 169963002432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963002433 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 169963002434 dimer interface [polypeptide binding]; other site 169963002435 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 169963002436 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 169963002437 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963002438 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 169963002439 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 169963002440 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 169963002441 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963002442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963002443 Coenzyme A binding pocket [chemical binding]; other site 169963002444 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cd12087 169963002445 dimer interface [polypeptide binding]; other site 169963002446 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963002447 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963002448 DNA binding residues [nucleotide binding] 169963002449 putative dimer interface [polypeptide binding]; other site 169963002450 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963002451 active site 169963002452 catalytic tetrad [active] 169963002453 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 169963002454 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 169963002455 homodimer interface [polypeptide binding]; other site 169963002456 catalytic residues [active] 169963002457 NAD binding site [chemical binding]; other site 169963002458 substrate binding pocket [chemical binding]; other site 169963002459 flexible flap; other site 169963002460 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 169963002461 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 169963002462 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 169963002463 PhoU domain; Region: PhoU; pfam01895 169963002464 PhoU domain; Region: PhoU; pfam01895 169963002465 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 169963002466 Homeodomain-like domain; Region: HTH_23; pfam13384 169963002467 putative transposase OrfB; Reviewed; Region: PHA02517 169963002468 HTH-like domain; Region: HTH_21; pfam13276 169963002469 Integrase core domain; Region: rve; pfam00665 169963002470 Integrase core domain; Region: rve_3; cl15866 169963002471 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 169963002472 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 169963002473 dimer interface [polypeptide binding]; other site 169963002474 PYR/PP interface [polypeptide binding]; other site 169963002475 TPP binding site [chemical binding]; other site 169963002476 substrate binding site [chemical binding]; other site 169963002477 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 169963002478 Domain of unknown function; Region: EKR; smart00890 169963002479 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 169963002480 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 169963002481 TPP-binding site [chemical binding]; other site 169963002482 dimer interface [polypeptide binding]; other site 169963002483 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 169963002484 Predicted permeases [General function prediction only]; Region: COG0679 169963002485 Helix-turn-helix domain; Region: HTH_28; pfam13518 169963002486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963002487 non-specific DNA binding site [nucleotide binding]; other site 169963002488 salt bridge; other site 169963002489 sequence-specific DNA binding site [nucleotide binding]; other site 169963002490 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 169963002491 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963002492 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963002493 Predicted membrane protein [Function unknown]; Region: COG3223 169963002494 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963002495 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963002496 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 169963002497 Walker A/P-loop; other site 169963002498 ATP binding site [chemical binding]; other site 169963002499 Q-loop/lid; other site 169963002500 ABC transporter signature motif; other site 169963002501 Walker B; other site 169963002502 D-loop; other site 169963002503 H-loop/switch region; other site 169963002504 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 169963002505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963002506 putative substrate translocation pore; other site 169963002507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963002508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963002509 putative substrate translocation pore; other site 169963002510 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963002511 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 169963002512 putative DNA binding site [nucleotide binding]; other site 169963002513 putative Zn2+ binding site [ion binding]; other site 169963002514 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 169963002515 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 169963002516 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963002517 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 169963002518 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963002519 motif II; other site 169963002520 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 169963002521 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002522 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002523 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002524 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002525 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002526 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002527 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963002528 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963002529 Predicted membrane protein [Function unknown]; Region: COG3326 169963002530 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 169963002531 homotrimer interaction site [polypeptide binding]; other site 169963002532 putative active site [active] 169963002533 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 169963002534 substrate binding site [chemical binding]; other site 169963002535 zinc-binding site [ion binding]; other site 169963002536 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 169963002537 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 169963002538 GIY-YIG motif/motif A; other site 169963002539 active site 169963002540 catalytic site [active] 169963002541 putative DNA binding site [nucleotide binding]; other site 169963002542 metal binding site [ion binding]; metal-binding site 169963002543 UvrB/uvrC motif; Region: UVR; pfam02151 169963002544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 169963002545 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 169963002546 substrate binding pocket [chemical binding]; other site 169963002547 membrane-bound complex binding site; other site 169963002548 hinge residues; other site 169963002549 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963002550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002551 dimer interface [polypeptide binding]; other site 169963002552 conserved gate region; other site 169963002553 putative PBP binding loops; other site 169963002554 ABC-ATPase subunit interface; other site 169963002555 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 169963002556 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 169963002557 Walker A/P-loop; other site 169963002558 ATP binding site [chemical binding]; other site 169963002559 Q-loop/lid; other site 169963002560 ABC transporter signature motif; other site 169963002561 Walker B; other site 169963002562 D-loop; other site 169963002563 H-loop/switch region; other site 169963002564 amidase; Provisional; Region: PRK11910 169963002565 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 169963002566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963002567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963002568 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 169963002569 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 169963002570 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 169963002571 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 169963002572 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 169963002573 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 169963002574 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 169963002575 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 169963002576 Esterase/lipase [General function prediction only]; Region: COG1647 169963002577 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963002578 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963002579 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963002580 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963002581 DNA binding site [nucleotide binding] 169963002582 domain linker motif; other site 169963002583 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 169963002584 putative dimerization interface [polypeptide binding]; other site 169963002585 putative ligand binding site [chemical binding]; other site 169963002586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963002587 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 169963002588 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 169963002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002590 dimer interface [polypeptide binding]; other site 169963002591 conserved gate region; other site 169963002592 putative PBP binding loops; other site 169963002593 ABC-ATPase subunit interface; other site 169963002594 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963002595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963002596 dimer interface [polypeptide binding]; other site 169963002597 conserved gate region; other site 169963002598 putative PBP binding loops; other site 169963002599 ABC-ATPase subunit interface; other site 169963002600 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 169963002601 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 169963002602 active site 169963002603 catalytic site [active] 169963002604 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 169963002605 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 169963002606 active site 169963002607 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 169963002608 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 169963002609 active site 169963002610 substrate binding site [chemical binding]; other site 169963002611 metal binding site [ion binding]; metal-binding site 169963002612 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 169963002613 DEAD-like helicases superfamily; Region: DEXDc; smart00487 169963002614 ATP binding site [chemical binding]; other site 169963002615 Mg++ binding site [ion binding]; other site 169963002616 motif III; other site 169963002617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963002618 nucleotide binding region [chemical binding]; other site 169963002619 ATP-binding site [chemical binding]; other site 169963002620 Predicted membrane protein [Function unknown]; Region: COG4708 169963002621 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 169963002622 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 169963002623 Predicted transcriptional regulators [Transcription]; Region: COG1733 169963002624 putative Zn2+ binding site [ion binding]; other site 169963002625 putative DNA binding site [nucleotide binding]; other site 169963002626 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 169963002627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963002628 putative substrate translocation pore; other site 169963002629 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963002630 PRD domain; Region: PRD; pfam00874 169963002631 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963002632 active site 169963002633 P-loop; other site 169963002634 phosphorylation site [posttranslational modification] 169963002635 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963002636 active site 169963002637 phosphorylation site [posttranslational modification] 169963002638 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963002639 methionine cluster; other site 169963002640 active site 169963002641 phosphorylation site [posttranslational modification] 169963002642 metal binding site [ion binding]; metal-binding site 169963002643 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963002644 active site 169963002645 P-loop; other site 169963002646 phosphorylation site [posttranslational modification] 169963002647 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963002648 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 169963002649 active site 169963002650 trimer interface [polypeptide binding]; other site 169963002651 allosteric site; other site 169963002652 active site lid [active] 169963002653 hexamer (dimer of trimers) interface [polypeptide binding]; other site 169963002654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963002655 active site 169963002656 catalytic tetrad [active] 169963002657 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 169963002658 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 169963002659 Collagen binding domain; Region: Collagen_bind; pfam05737 169963002660 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 169963002661 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963002662 Uncharacterized conserved protein [Function unknown]; Region: COG3402 169963002663 Predicted membrane protein [Function unknown]; Region: COG3428 169963002664 Bacterial PH domain; Region: bPH_2; pfam03703 169963002665 Bacterial PH domain; Region: bPH_2; pfam03703 169963002666 Bacterial PH domain; Region: bPH_2; pfam03703 169963002667 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 169963002668 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 169963002669 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 169963002670 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 169963002671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 169963002672 active site 169963002673 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 169963002674 dimer interface [polypeptide binding]; other site 169963002675 substrate binding site [chemical binding]; other site 169963002676 catalytic residues [active] 169963002677 5' nucleotidase family; Region: 5_nucleotid; cl17687 169963002678 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 169963002679 PemK-like protein; Region: PemK; pfam02452 169963002680 Rsbr N terminal; Region: Rsbr_N; pfam08678 169963002681 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963002682 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963002683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963002684 ATP binding site [chemical binding]; other site 169963002685 Mg2+ binding site [ion binding]; other site 169963002686 G-X-G motif; other site 169963002687 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 169963002688 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 169963002689 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 169963002690 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 169963002691 anti sigma factor interaction site; other site 169963002692 regulatory phosphorylation site [posttranslational modification]; other site 169963002693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963002694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 169963002695 ATP binding site [chemical binding]; other site 169963002696 Mg2+ binding site [ion binding]; other site 169963002697 G-X-G motif; other site 169963002698 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 169963002699 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 169963002700 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 169963002701 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 169963002702 DNA binding residues [nucleotide binding] 169963002703 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 169963002704 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 169963002705 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 169963002706 Sulfate transporter family; Region: Sulfate_transp; pfam00916 169963002707 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 169963002708 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 169963002709 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 169963002710 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 169963002711 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 169963002712 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 169963002713 RNA binding site [nucleotide binding]; other site 169963002714 hypothetical protein; Provisional; Region: PRK04351 169963002715 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 169963002716 Uncharacterized conserved protein [Function unknown]; Region: COG5646 169963002717 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963002718 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963002719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002720 DNA-binding site [nucleotide binding]; DNA binding site 169963002721 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 169963002722 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 169963002723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 169963002724 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 169963002725 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 169963002726 glutathione reductase; Validated; Region: PRK06116 169963002727 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963002728 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963002729 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 169963002730 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963002731 catalytic core [active] 169963002732 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 169963002733 Predicted transcriptional regulators [Transcription]; Region: COG1725 169963002734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002735 DNA-binding site [nucleotide binding]; DNA binding site 169963002736 Predicted membrane protein [General function prediction only]; Region: COG4194 169963002737 Integron-associated effector binding protein; Region: Cass2; pfam14526 169963002738 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 169963002739 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 169963002740 tetramerization interface [polypeptide binding]; other site 169963002741 NAD(P) binding site [chemical binding]; other site 169963002742 catalytic residues [active] 169963002743 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 169963002744 active site 169963002745 P-loop; other site 169963002746 phosphorylation site [posttranslational modification] 169963002747 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963002748 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963002749 methionine cluster; other site 169963002750 active site 169963002751 phosphorylation site [posttranslational modification] 169963002752 metal binding site [ion binding]; metal-binding site 169963002753 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963002754 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963002755 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963002756 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963002757 PRD domain; Region: PRD; pfam00874 169963002758 PRD domain; Region: PRD; pfam00874 169963002759 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 169963002760 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 169963002761 active site 169963002762 phosphorylation site [posttranslational modification] 169963002763 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 169963002764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963002765 ABC transporter; Region: ABC_tran_2; pfam12848 169963002766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963002767 Predicted permeases [General function prediction only]; Region: COG0701 169963002768 Predicted membrane protein [Function unknown]; Region: COG3689 169963002769 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 169963002770 ATP-binding site [chemical binding]; other site 169963002771 CoA-binding site [chemical binding]; other site 169963002772 Mg2+-binding site [ion binding]; other site 169963002773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963002774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963002775 Walker A/P-loop; other site 169963002776 ATP binding site [chemical binding]; other site 169963002777 Q-loop/lid; other site 169963002778 ABC transporter signature motif; other site 169963002779 Walker B; other site 169963002780 ABC transporter, ATP-binding protein (C-terminal part) 169963002781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 169963002782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 169963002783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963002784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963002785 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 169963002786 Domain of unknown function (DUF373); Region: DUF373; cl12079 169963002787 Sulfatase; Region: Sulfatase; pfam00884 169963002788 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 169963002789 active site 169963002790 DNA binding site [nucleotide binding] 169963002791 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 169963002792 active site 169963002793 catalytic site [active] 169963002794 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 169963002795 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 169963002796 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 169963002797 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 169963002798 Uncharacterized conserved protein [Function unknown]; Region: COG0398 169963002799 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 169963002800 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 169963002801 Ligand binding site; other site 169963002802 Putative Catalytic site; other site 169963002803 DXD motif; other site 169963002804 epoxyqueuosine reductase; Region: TIGR00276 169963002805 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 169963002806 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 169963002807 A new structural DNA glycosylase; Region: AlkD_like; cl11434 169963002808 active site 169963002809 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 169963002810 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 169963002811 dimer interface [polypeptide binding]; other site 169963002812 FMN binding site [chemical binding]; other site 169963002813 NADPH bind site [chemical binding]; other site 169963002814 Low molecular weight phosphatase family; Region: LMWPc; cd00115 169963002815 active site 169963002816 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 169963002817 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 169963002818 HSP90 family protein; Provisional; Region: PRK14083 169963002819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963002820 ATP binding site [chemical binding]; other site 169963002821 Mg2+ binding site [ion binding]; other site 169963002822 G-X-G motif; other site 169963002823 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 169963002824 Ferritin-like domain; Region: Ferritin; pfam00210 169963002825 dimerization interface [polypeptide binding]; other site 169963002826 DPS ferroxidase diiron center [ion binding]; other site 169963002827 ion pore; other site 169963002828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 169963002829 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 169963002830 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 169963002831 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 169963002832 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 169963002833 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 169963002834 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 169963002835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963002836 putative substrate translocation pore; other site 169963002837 Transcriptional regulators [Transcription]; Region: FadR; COG2186 169963002838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002839 DNA-binding site [nucleotide binding]; DNA binding site 169963002840 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 169963002841 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 169963002842 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963002843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 169963002844 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963002845 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 169963002846 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 169963002847 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 169963002848 TIGR01666 family membrane protein; Region: YCCS 169963002849 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 169963002850 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 169963002851 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 169963002852 active site 169963002853 dimer interface [polypeptide binding]; other site 169963002854 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 169963002855 active site 169963002856 trimer interface [polypeptide binding]; other site 169963002857 allosteric site; other site 169963002858 active site lid [active] 169963002859 hexamer (dimer of trimers) interface [polypeptide binding]; other site 169963002860 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963002861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963002862 DNA-binding site [nucleotide binding]; DNA binding site 169963002863 UTRA domain; Region: UTRA; pfam07702 169963002864 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 169963002865 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 169963002866 Mg++ binding site [ion binding]; other site 169963002867 putative catalytic motif [active] 169963002868 substrate binding site [chemical binding]; other site 169963002869 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 169963002870 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 169963002871 putative protease; Provisional; Region: PRK15452 169963002872 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 169963002873 heat shock protein HtpX; Provisional; Region: PRK04897 169963002874 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 169963002875 catalytic residues [active] 169963002876 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 169963002877 putative active site [active] 169963002878 putative metal binding residues [ion binding]; other site 169963002879 signature motif; other site 169963002880 putative triphosphate binding site [ion binding]; other site 169963002881 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963002882 TPR motif; other site 169963002883 binding surface 169963002884 Tetratricopeptide repeat; Region: TPR_16; pfam13432 169963002885 Tetratrico peptide repeat; Region: TPR_5; pfam12688 169963002886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963002887 binding surface 169963002888 TPR motif; other site 169963002889 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 169963002890 synthetase active site [active] 169963002891 NTP binding site [chemical binding]; other site 169963002892 metal binding site [ion binding]; metal-binding site 169963002893 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 169963002894 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 169963002895 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 169963002896 active site 169963002897 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 169963002898 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 169963002899 NAD binding site [chemical binding]; other site 169963002900 homotetramer interface [polypeptide binding]; other site 169963002901 homodimer interface [polypeptide binding]; other site 169963002902 substrate binding site [chemical binding]; other site 169963002903 active site 169963002904 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 169963002905 DltD N-terminal region; Region: DltD_N; pfam04915 169963002906 DltD central region; Region: DltD_M; pfam04918 169963002907 DltD C-terminal region; Region: DltD_C; pfam04914 169963002908 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 169963002909 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 169963002910 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 169963002911 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 169963002912 acyl-activating enzyme (AAE) consensus motif; other site 169963002913 AMP binding site [chemical binding]; other site 169963002914 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 169963002915 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963002916 active site 169963002917 dimer interface [polypeptide binding]; other site 169963002918 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963002919 Coenzyme A binding pocket [chemical binding]; other site 169963002920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963002921 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 169963002922 Putative esterase; Region: Esterase; pfam00756 169963002923 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 169963002924 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 169963002925 homodimer interface [polypeptide binding]; other site 169963002926 substrate-cofactor binding pocket; other site 169963002927 catalytic residue [active] 169963002928 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 169963002929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963002930 Walker A/P-loop; other site 169963002931 ATP binding site [chemical binding]; other site 169963002932 Q-loop/lid; other site 169963002933 ABC transporter signature motif; other site 169963002934 Walker B; other site 169963002935 D-loop; other site 169963002936 H-loop/switch region; other site 169963002937 ABC-2 type transporter; Region: ABC2_membrane; cl17235 169963002938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 169963002939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963002940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963002941 putative substrate translocation pore; other site 169963002942 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 169963002943 putative oligomer interface [polypeptide binding]; other site 169963002944 putative active site [active] 169963002945 metal binding site [ion binding]; metal-binding site 169963002946 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 169963002947 catalytic residues [active] 169963002948 dimer interface [polypeptide binding]; other site 169963002949 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 169963002950 LytTr DNA-binding domain; Region: LytTR; pfam04397 169963002951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963002952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963002953 Walker A/P-loop; other site 169963002954 ATP binding site [chemical binding]; other site 169963002955 Q-loop/lid; other site 169963002956 ABC transporter signature motif; other site 169963002957 Walker B; other site 169963002958 D-loop; other site 169963002959 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 169963002960 H-loop/switch region; other site 169963002961 ABC-2 type transporter; Region: ABC2_membrane; cl17235 169963002962 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 169963002963 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 169963002964 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 169963002965 G1 box; other site 169963002966 putative GEF interaction site [polypeptide binding]; other site 169963002967 GTP/Mg2+ binding site [chemical binding]; other site 169963002968 Switch I region; other site 169963002969 G2 box; other site 169963002970 G3 box; other site 169963002971 Switch II region; other site 169963002972 G4 box; other site 169963002973 G5 box; other site 169963002974 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 169963002975 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963002976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963002977 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 169963002978 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 169963002979 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 169963002980 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 169963002981 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 169963002982 Cation transport protein; Region: TrkH; cl17365 169963002983 Cation transport protein; Region: TrkH; pfam02386 169963002984 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 169963002985 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 169963002986 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 169963002987 DNA binding site [nucleotide binding] 169963002988 active site 169963002989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963002990 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 169963002991 Walker A motif; other site 169963002992 ATP binding site [chemical binding]; other site 169963002993 Walker B motif; other site 169963002994 arginine finger; other site 169963002995 UvrB/uvrC motif; Region: UVR; pfam02151 169963002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963002997 Walker A motif; other site 169963002998 ATP binding site [chemical binding]; other site 169963002999 Walker B motif; other site 169963003000 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 169963003001 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 169963003002 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963003003 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 169963003004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 169963003005 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 169963003006 dimerization domain swap beta strand [polypeptide binding]; other site 169963003007 regulatory protein interface [polypeptide binding]; other site 169963003008 active site 169963003009 regulatory phosphorylation site [posttranslational modification]; other site 169963003010 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 169963003011 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 169963003012 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 169963003013 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 169963003014 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 169963003015 putative active site [active] 169963003016 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 169963003017 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 169963003018 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 169963003019 aminotransferase A; Validated; Region: PRK07683 169963003020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963003021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963003022 homodimer interface [polypeptide binding]; other site 169963003023 catalytic residue [active] 169963003024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 169963003025 FOG: CBS domain [General function prediction only]; Region: COG0517 169963003026 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 169963003027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963003028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963003029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 169963003030 dimerization interface [polypeptide binding]; other site 169963003031 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 169963003032 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 169963003033 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 169963003034 putative trimer interface [polypeptide binding]; other site 169963003035 putative CoA binding site [chemical binding]; other site 169963003036 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 169963003037 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 169963003038 metal binding site [ion binding]; metal-binding site 169963003039 putative dimer interface [polypeptide binding]; other site 169963003040 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 169963003041 Mechanosensitive ion channel; Region: MS_channel; pfam00924 169963003042 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 169963003043 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 169963003044 Walker A/P-loop; other site 169963003045 ATP binding site [chemical binding]; other site 169963003046 Q-loop/lid; other site 169963003047 ABC transporter signature motif; other site 169963003048 Walker B; other site 169963003049 D-loop; other site 169963003050 H-loop/switch region; other site 169963003051 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 169963003052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963003053 dimer interface [polypeptide binding]; other site 169963003054 conserved gate region; other site 169963003055 putative PBP binding loops; other site 169963003056 ABC-ATPase subunit interface; other site 169963003057 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 169963003058 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 169963003059 HPr interaction site; other site 169963003060 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963003061 active site 169963003062 phosphorylation site [posttranslational modification] 169963003063 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 169963003064 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 169963003065 S1 domain; Region: S1_2; pfam13509 169963003066 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 169963003067 RNA binding site [nucleotide binding]; other site 169963003068 Predicted membrane protein [Function unknown]; Region: COG4758 169963003069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 169963003070 Histidine kinase; Region: HisKA_3; pfam07730 169963003071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963003072 ATP binding site [chemical binding]; other site 169963003073 Mg2+ binding site [ion binding]; other site 169963003074 G-X-G motif; other site 169963003075 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 169963003076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963003077 active site 169963003078 phosphorylation site [posttranslational modification] 169963003079 intermolecular recognition site; other site 169963003080 dimerization interface [polypeptide binding]; other site 169963003081 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 169963003082 DNA binding residues [nucleotide binding] 169963003083 dimerization interface [polypeptide binding]; other site 169963003084 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 169963003085 TrkA-N domain; Region: TrkA_N; pfam02254 169963003086 TrkA-C domain; Region: TrkA_C; pfam02080 169963003087 Predicted membrane protein [Function unknown]; Region: COG1289 169963003088 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 169963003089 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 169963003090 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 169963003091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 169963003092 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 169963003093 Uncharacterized conserved small protein [Function unknown]; Region: COG5503 169963003094 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963003095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963003096 active site 169963003097 motif I; other site 169963003098 motif II; other site 169963003099 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963003100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963003101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963003102 DNA binding site [nucleotide binding] 169963003103 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963003104 ligand binding site [chemical binding]; other site 169963003105 dimerization interface [polypeptide binding]; other site 169963003106 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 169963003107 hexamer (dimer of trimers) interface [polypeptide binding]; other site 169963003108 trimer interface [polypeptide binding]; other site 169963003109 substrate binding site [chemical binding]; other site 169963003110 Mn binding site [ion binding]; other site 169963003111 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 169963003112 TPP-binding site [chemical binding]; other site 169963003113 dimer interface [polypeptide binding]; other site 169963003114 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 169963003115 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 169963003116 PYR/PP interface [polypeptide binding]; other site 169963003117 dimer interface [polypeptide binding]; other site 169963003118 TPP binding site [chemical binding]; other site 169963003119 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963003120 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 169963003121 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 169963003122 N- and C-terminal domain interface [polypeptide binding]; other site 169963003123 active site 169963003124 MgATP binding site [chemical binding]; other site 169963003125 catalytic site [active] 169963003126 metal binding site [ion binding]; metal-binding site 169963003127 putative glycerol binding site [chemical binding]; other site 169963003128 putative homotetramer interface [polypeptide binding]; other site 169963003129 putative homodimer interface [polypeptide binding]; other site 169963003130 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 169963003131 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963003132 active site turn [active] 169963003133 phosphorylation site [posttranslational modification] 169963003134 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963003135 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 169963003136 HPr interaction site; other site 169963003137 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963003138 active site 169963003139 phosphorylation site [posttranslational modification] 169963003140 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 169963003141 Protein of unknown function (DUF817); Region: DUF817; pfam05675 169963003142 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 169963003143 GTP binding site; other site 169963003144 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 169963003145 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 169963003146 Walker A/P-loop; other site 169963003147 ATP binding site [chemical binding]; other site 169963003148 Q-loop/lid; other site 169963003149 ABC transporter signature motif; other site 169963003150 Walker B; other site 169963003151 D-loop; other site 169963003152 H-loop/switch region; other site 169963003153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963003154 dimer interface [polypeptide binding]; other site 169963003155 conserved gate region; other site 169963003156 putative PBP binding loops; other site 169963003157 ABC-ATPase subunit interface; other site 169963003158 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 169963003159 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 169963003160 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 169963003161 dimer interface [polypeptide binding]; other site 169963003162 putative functional site; other site 169963003163 putative MPT binding site; other site 169963003164 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 169963003165 Walker A motif; other site 169963003166 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 169963003167 MoaE homodimer interface [polypeptide binding]; other site 169963003168 MoaD interaction [polypeptide binding]; other site 169963003169 active site residues [active] 169963003170 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 169963003171 MoaE interaction surface [polypeptide binding]; other site 169963003172 MoeB interaction surface [polypeptide binding]; other site 169963003173 thiocarboxylated glycine; other site 169963003174 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 169963003175 trimer interface [polypeptide binding]; other site 169963003176 dimer interface [polypeptide binding]; other site 169963003177 putative active site [active] 169963003178 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 169963003179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 169963003180 FeS/SAM binding site; other site 169963003181 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 169963003182 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 169963003183 MPT binding site; other site 169963003184 trimer interface [polypeptide binding]; other site 169963003185 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 169963003186 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 169963003187 ATP binding site [chemical binding]; other site 169963003188 substrate interface [chemical binding]; other site 169963003189 Flavin Reductases; Region: FlaRed; cl00801 169963003190 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 169963003191 active site 169963003192 catalytic residues [active] 169963003193 metal binding site [ion binding]; metal-binding site 169963003194 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 169963003195 TPP-binding site [chemical binding]; other site 169963003196 tetramer interface [polypeptide binding]; other site 169963003197 heterodimer interface [polypeptide binding]; other site 169963003198 phosphorylation loop region [posttranslational modification] 169963003199 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 169963003200 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 169963003201 alpha subunit interface [polypeptide binding]; other site 169963003202 TPP binding site [chemical binding]; other site 169963003203 heterodimer interface [polypeptide binding]; other site 169963003204 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963003205 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 169963003206 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 169963003207 E3 interaction surface; other site 169963003208 lipoyl attachment site [posttranslational modification]; other site 169963003209 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 169963003210 E3 interaction surface; other site 169963003211 lipoyl attachment site [posttranslational modification]; other site 169963003212 e3 binding domain; Region: E3_binding; pfam02817 169963003213 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 169963003214 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 169963003215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963003216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963003217 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 169963003218 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 169963003219 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 169963003220 NAD(P) binding site [chemical binding]; other site 169963003221 LDH/MDH dimer interface [polypeptide binding]; other site 169963003222 substrate binding site [chemical binding]; other site 169963003223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 169963003224 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 169963003225 Thioredoxin; Region: Thioredoxin_4; pfam13462 169963003226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963003227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963003228 active site 169963003229 phosphorylation site [posttranslational modification] 169963003230 intermolecular recognition site; other site 169963003231 dimerization interface [polypeptide binding]; other site 169963003232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963003233 DNA binding site [nucleotide binding] 169963003234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 169963003235 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963003236 dimerization interface [polypeptide binding]; other site 169963003237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963003238 dimer interface [polypeptide binding]; other site 169963003239 phosphorylation site [posttranslational modification] 169963003240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963003241 ATP binding site [chemical binding]; other site 169963003242 Mg2+ binding site [ion binding]; other site 169963003243 G-X-G motif; other site 169963003244 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963003245 FtsX-like permease family; Region: FtsX; pfam02687 169963003246 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963003247 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963003248 Walker A/P-loop; other site 169963003249 ATP binding site [chemical binding]; other site 169963003250 Q-loop/lid; other site 169963003251 ABC transporter signature motif; other site 169963003252 Walker B; other site 169963003253 D-loop; other site 169963003254 H-loop/switch region; other site 169963003255 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 169963003256 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 169963003257 Cl binding site [ion binding]; other site 169963003258 oligomer interface [polypeptide binding]; other site 169963003259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 169963003260 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 169963003261 active site 169963003262 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 169963003263 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 169963003264 G1 box; other site 169963003265 putative GEF interaction site [polypeptide binding]; other site 169963003266 GTP/Mg2+ binding site [chemical binding]; other site 169963003267 Switch I region; other site 169963003268 G2 box; other site 169963003269 G3 box; other site 169963003270 Switch II region; other site 169963003271 G4 box; other site 169963003272 G5 box; other site 169963003273 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 169963003274 Elongation Factor G, domain II; Region: EFG_II; pfam14492 169963003275 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 169963003276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 169963003277 hypothetical protein; Provisional; Region: PRK13666 169963003278 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 169963003279 Pyruvate carboxylase [Energy production and conversion]; Region: PycA; COG1038 169963003280 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 169963003281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 169963003282 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 169963003283 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 169963003284 active site 169963003285 catalytic residues [active] 169963003286 metal binding site [ion binding]; metal-binding site 169963003287 homodimer binding site [polypeptide binding]; other site 169963003288 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 169963003289 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 169963003290 carboxyltransferase (CT) interaction site; other site 169963003291 biotinylation site [posttranslational modification]; other site 169963003292 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 169963003293 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 169963003294 putative binding site residues; other site 169963003295 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 169963003296 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 169963003297 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 169963003298 Walker A/P-loop; other site 169963003299 ATP binding site [chemical binding]; other site 169963003300 Q-loop/lid; other site 169963003301 ABC transporter signature motif; other site 169963003302 Walker B; other site 169963003303 D-loop; other site 169963003304 H-loop/switch region; other site 169963003305 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963003306 SH3-like domain; Region: SH3_8; pfam13457 169963003307 SH3-like domain; Region: SH3_8; pfam13457 169963003308 SH3-like domain; Region: SH3_8; pfam13457 169963003309 SH3-like domain; Region: SH3_8; pfam13457 169963003310 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 169963003311 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 169963003312 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 169963003313 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 169963003314 active site 169963003315 tetramer interface; other site 169963003316 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 169963003317 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 169963003318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 169963003319 active site 169963003320 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 169963003321 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 169963003322 substrate binding site; other site 169963003323 tetramer interface; other site 169963003324 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 169963003325 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 169963003326 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 169963003327 NAD binding site [chemical binding]; other site 169963003328 substrate binding site [chemical binding]; other site 169963003329 homodimer interface [polypeptide binding]; other site 169963003330 active site 169963003331 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 169963003332 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 169963003333 NADP binding site [chemical binding]; other site 169963003334 active site 169963003335 putative substrate binding site [chemical binding]; other site 169963003336 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 169963003337 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 169963003338 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 169963003339 substrate binding site; other site 169963003340 dimer interface; other site 169963003341 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 169963003342 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 169963003343 putative NAD(P) binding site [chemical binding]; other site 169963003344 putative catalytic Zn binding site [ion binding]; other site 169963003345 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 169963003346 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 169963003347 active site 169963003348 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 169963003349 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 169963003350 active site 169963003351 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 169963003352 active site 169963003353 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 169963003354 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 169963003355 active site 169963003356 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 169963003357 homodimer interface [polypeptide binding]; other site 169963003358 NAD binding pocket [chemical binding]; other site 169963003359 ATP binding pocket [chemical binding]; other site 169963003360 Mg binding site [ion binding]; other site 169963003361 active-site loop [active] 169963003362 Uncharacterized conserved protein [Function unknown]; Region: COG1359 169963003363 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 169963003364 active site 169963003365 P-loop; other site 169963003366 phosphorylation site [posttranslational modification] 169963003367 GMP synthase; Reviewed; Region: guaA; PRK00074 169963003368 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 169963003369 AMP/PPi binding site [chemical binding]; other site 169963003370 candidate oxyanion hole; other site 169963003371 catalytic triad [active] 169963003372 potential glutamine specificity residues [chemical binding]; other site 169963003373 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 169963003374 ATP Binding subdomain [chemical binding]; other site 169963003375 Ligand Binding sites [chemical binding]; other site 169963003376 Dimerization subdomain; other site 169963003377 AP2-like DNA-binding integrase domain; Region: Integrase_AP2; pfam14657 169963003378 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 169963003379 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_3; pfam14659 169963003380 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 169963003381 Int/Topo IB signature motif; other site 169963003382 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 169963003383 Helix-turn-helix domain; Region: HTH_16; pfam12645 169963003384 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 169963003385 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 169963003386 DNA binding residues [nucleotide binding] 169963003387 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 169963003388 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 169963003389 metal-binding site [ion binding] 169963003390 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963003391 Soluble P-type ATPase [General function prediction only]; Region: COG4087 169963003392 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 169963003393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963003394 dimerization interface [polypeptide binding]; other site 169963003395 putative DNA binding site [nucleotide binding]; other site 169963003396 putative Zn2+ binding site [ion binding]; other site 169963003397 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 169963003398 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 169963003399 N-acetyl-D-glucosamine binding site [chemical binding]; other site 169963003400 catalytic residue [active] 169963003401 NlpC/P60 family; Region: NLPC_P60; pfam00877 169963003402 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963003403 AAA-like domain; Region: AAA_10; pfam12846 169963003404 TcpE family; Region: TcpE; pfam12648 169963003405 Antirestriction protein (ArdA); Region: ArdA; pfam07275 169963003406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963003407 non-specific DNA binding site [nucleotide binding]; other site 169963003408 salt bridge; other site 169963003409 sequence-specific DNA binding site [nucleotide binding]; other site 169963003410 Replication initiation factor; Region: Rep_trans; pfam02486 169963003411 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 169963003412 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 169963003413 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 169963003414 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 169963003415 Cna protein B-type domain; Region: Cna_B; pfam05738 169963003416 Cna protein B-type domain; Region: Cna_B; pfam05738 169963003417 Cna protein B-type domain; Region: Cna_B; pfam05738 169963003418 Cna protein B-type domain; Region: Cna_B; pfam05738 169963003419 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963003420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963003421 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 169963003422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 169963003423 active site 169963003424 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 169963003425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963003426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963003427 MepB protein; Region: MepB; cl01985 169963003428 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 169963003429 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963003430 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963003431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963003432 Coenzyme A binding pocket [chemical binding]; other site 169963003433 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963003434 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 169963003435 DNA binding residues [nucleotide binding] 169963003436 drug binding residues [chemical binding]; other site 169963003437 dimer interface [polypeptide binding]; other site 169963003438 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 169963003439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963003440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963003441 Walker A/P-loop; other site 169963003442 ATP binding site [chemical binding]; other site 169963003443 Q-loop/lid; other site 169963003444 ABC transporter signature motif; other site 169963003445 Walker B; other site 169963003446 D-loop; other site 169963003447 H-loop/switch region; other site 169963003448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963003449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963003450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963003451 Walker A/P-loop; other site 169963003452 ATP binding site [chemical binding]; other site 169963003453 Q-loop/lid; other site 169963003454 ABC transporter signature motif; other site 169963003455 Walker B; other site 169963003456 D-loop; other site 169963003457 H-loop/switch region; other site 169963003458 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 169963003459 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963003460 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963003461 DNA binding residues [nucleotide binding] 169963003462 putative dimer interface [polypeptide binding]; other site 169963003463 Immunity protein 14; Region: Imm14; pfam15428 169963003464 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963003465 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963003466 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003467 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003468 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003469 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003470 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003471 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963003472 LRR adjacent; Region: LRR_adjacent; pfam08191 169963003473 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963003474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 169963003475 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 169963003476 oligomer interface [polypeptide binding]; other site 169963003477 active site residues [active] 169963003478 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 169963003479 dimer interface [polypeptide binding]; other site 169963003480 precorrin-2 dehydrogenase; Validated; Region: PRK06719 169963003481 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 169963003482 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 169963003483 SLBB domain; Region: SLBB; pfam10531 169963003484 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 169963003485 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 169963003486 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003487 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 169963003488 putative hexamer interface [polypeptide binding]; other site 169963003489 putative hexagonal pore; other site 169963003490 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 169963003491 putative hexamer interface [polypeptide binding]; other site 169963003492 putative hexagonal pore; other site 169963003493 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 169963003494 putative hexamer interface [polypeptide binding]; other site 169963003495 putative hexagonal pore; other site 169963003496 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 169963003497 G1 box; other site 169963003498 GTP/Mg2+ binding site [chemical binding]; other site 169963003499 G2 box; other site 169963003500 Switch I region; other site 169963003501 G3 box; other site 169963003502 Switch II region; other site 169963003503 G4 box; other site 169963003504 G5 box; other site 169963003505 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 169963003506 homotrimer interface [polypeptide binding]; other site 169963003507 Walker A motif; other site 169963003508 GTP binding site [chemical binding]; other site 169963003509 Walker B motif; other site 169963003510 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 169963003511 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963003512 catalytic core [active] 169963003513 Sensory domain found in PocR; Region: PocR; cl19879 169963003514 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963003515 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 169963003516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963003517 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003518 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 169963003519 Hexamer interface [polypeptide binding]; other site 169963003520 Hexagonal pore residue; other site 169963003521 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 169963003522 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 169963003523 putative hexamer interface [polypeptide binding]; other site 169963003524 putative hexagonal pore; other site 169963003525 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 169963003526 putative hexamer interface [polypeptide binding]; other site 169963003527 putative hexagonal pore; other site 169963003528 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 169963003529 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 169963003530 alpha-beta subunit interface [polypeptide binding]; other site 169963003531 alpha-gamma subunit interface [polypeptide binding]; other site 169963003532 active site 169963003533 substrate and K+ binding site; other site 169963003534 K+ binding site [ion binding]; other site 169963003535 cobalamin binding site [chemical binding]; other site 169963003536 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 169963003537 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 169963003538 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 169963003539 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 169963003540 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003541 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 169963003542 putative hexamer interface [polypeptide binding]; other site 169963003543 putative hexagonal pore; other site 169963003544 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003545 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 169963003546 Hexamer interface [polypeptide binding]; other site 169963003547 Hexagonal pore residue; other site 169963003548 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 169963003549 Propanediol utilisation protein PduL; Region: PduL; pfam06130 169963003550 Propanediol utilisation protein PduL; Region: PduL; pfam06130 169963003551 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 169963003552 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963003553 nucleotide binding site [chemical binding]; other site 169963003554 Cell division protein FtsA; Region: FtsA; cl17206 169963003555 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 169963003556 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 169963003557 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 169963003558 Hexamer/Pentamer interface [polypeptide binding]; other site 169963003559 central pore; other site 169963003560 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 169963003561 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 169963003562 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 169963003563 putative catalytic cysteine [active] 169963003564 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 169963003565 putative active site [active] 169963003566 metal binding site [ion binding]; metal-binding site 169963003567 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 169963003568 amphipathic channel; other site 169963003569 Asn-Pro-Ala signature motifs; other site 169963003570 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 169963003571 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 169963003572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963003573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963003574 homodimer interface [polypeptide binding]; other site 169963003575 catalytic residue [active] 169963003576 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 169963003577 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 169963003578 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 169963003579 putative active site [active] 169963003580 metal binding site [ion binding]; metal-binding site 169963003581 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 169963003582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963003583 active site 169963003584 phosphorylation site [posttranslational modification] 169963003585 intermolecular recognition site; other site 169963003586 dimerization interface [polypeptide binding]; other site 169963003587 ANTAR domain; Region: ANTAR; pfam03861 169963003588 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 169963003589 PAS domain; Region: PAS_9; pfam13426 169963003590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 169963003591 Histidine kinase; Region: HisKA_2; pfam07568 169963003592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963003593 ATP binding site [chemical binding]; other site 169963003594 Mg2+ binding site [ion binding]; other site 169963003595 G-X-G motif; other site 169963003596 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 169963003597 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 169963003598 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 169963003599 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 169963003600 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 169963003601 putative hexamer interface [polypeptide binding]; other site 169963003602 putative hexagonal pore; other site 169963003603 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 169963003604 putative hexamer interface [polypeptide binding]; other site 169963003605 putative hexagonal pore; other site 169963003606 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003607 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 169963003608 Hexamer interface [polypeptide binding]; other site 169963003609 Hexagonal pore residue; other site 169963003610 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 169963003611 putative catalytic cysteine [active] 169963003612 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 169963003613 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 169963003614 Hexamer interface [polypeptide binding]; other site 169963003615 Hexagonal pore residue; other site 169963003616 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 169963003617 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 169963003618 Propanediol utilisation protein PduL; Region: PduL; pfam06130 169963003619 Propanediol utilisation protein PduL; Region: PduL; pfam06130 169963003620 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 169963003621 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 169963003622 Hexamer/Pentamer interface [polypeptide binding]; other site 169963003623 central pore; other site 169963003624 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 169963003625 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 169963003626 putative hexamer interface [polypeptide binding]; other site 169963003627 putative hexagonal pore; other site 169963003628 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 169963003629 putative hexamer interface [polypeptide binding]; other site 169963003630 putative hexagonal pore; other site 169963003631 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 169963003632 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 169963003633 hypothetical protein; Region: PHA01818 169963003634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963003635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 169963003636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963003637 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 169963003638 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 169963003639 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 169963003640 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 169963003641 catalytic triad [active] 169963003642 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 169963003643 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 169963003644 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 169963003645 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 169963003646 active site 169963003647 putative homodimer interface [polypeptide binding]; other site 169963003648 SAM binding site [chemical binding]; other site 169963003649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963003650 S-adenosylmethionine binding site [chemical binding]; other site 169963003651 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 169963003652 active site 169963003653 SAM binding site [chemical binding]; other site 169963003654 homodimer interface [polypeptide binding]; other site 169963003655 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 169963003656 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 169963003657 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 169963003658 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 169963003659 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 169963003660 active site 169963003661 SAM binding site [chemical binding]; other site 169963003662 homodimer interface [polypeptide binding]; other site 169963003663 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 169963003664 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 169963003665 active site 169963003666 SAM binding site [chemical binding]; other site 169963003667 homodimer interface [polypeptide binding]; other site 169963003668 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 169963003669 active site 169963003670 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 169963003671 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 169963003672 active site 169963003673 C-terminal domain interface [polypeptide binding]; other site 169963003674 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 169963003675 active site 169963003676 N-terminal domain interface [polypeptide binding]; other site 169963003677 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 169963003678 active site 169963003679 SAM binding site [chemical binding]; other site 169963003680 homodimer interface [polypeptide binding]; other site 169963003681 cobalt transport protein CbiM; Validated; Region: PRK08319 169963003682 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 169963003683 cobalt transport protein CbiQ; Provisional; Region: PRK15485 169963003684 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 169963003685 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 169963003686 Walker A/P-loop; other site 169963003687 ATP binding site [chemical binding]; other site 169963003688 Q-loop/lid; other site 169963003689 ABC transporter signature motif; other site 169963003690 Walker B; other site 169963003691 D-loop; other site 169963003692 H-loop/switch region; other site 169963003693 cobyric acid synthase; Provisional; Region: PRK00784 169963003694 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 169963003695 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 169963003696 catalytic triad [active] 169963003697 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 169963003698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 169963003699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 169963003700 AAA domain; Region: AAA_17; cl19128 169963003701 Predicted transcriptional regulators [Transcription]; Region: COG1695 169963003702 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 169963003703 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963003704 SH3-like domain; Region: SH3_8; pfam13457 169963003705 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963003706 SH3-like domain; Region: SH3_8; pfam13457 169963003707 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 169963003708 oligomer interface [polypeptide binding]; other site 169963003709 active site 169963003710 metal binding site [ion binding]; metal-binding site 169963003711 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 169963003712 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 169963003713 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 169963003714 Predicted transcriptional regulators [Transcription]; Region: COG1733 169963003715 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 169963003716 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 169963003717 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 169963003718 dimer interface [polypeptide binding]; other site 169963003719 motif 1; other site 169963003720 active site 169963003721 motif 2; other site 169963003722 motif 3; other site 169963003723 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 169963003724 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 169963003725 putative tRNA-binding site [nucleotide binding]; other site 169963003726 B3/4 domain; Region: B3_4; pfam03483 169963003727 tRNA synthetase B5 domain; Region: B5; smart00874 169963003728 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 169963003729 dimer interface [polypeptide binding]; other site 169963003730 motif 1; other site 169963003731 motif 3; other site 169963003732 motif 2; other site 169963003733 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 169963003734 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963003735 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963003736 Walker A/P-loop; other site 169963003737 ATP binding site [chemical binding]; other site 169963003738 Q-loop/lid; other site 169963003739 ABC transporter signature motif; other site 169963003740 Walker B; other site 169963003741 D-loop; other site 169963003742 H-loop/switch region; other site 169963003743 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963003744 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 169963003745 FtsX-like permease family; Region: FtsX; pfam02687 169963003746 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 169963003747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963003748 FtsX-like permease family; Region: FtsX; pfam02687 169963003749 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963003750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963003751 putative DNA binding site [nucleotide binding]; other site 169963003752 putative Zn2+ binding site [ion binding]; other site 169963003753 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 169963003754 MMPL family; Region: MMPL; cl14618 169963003755 LXG domain of WXG superfamily; Region: LXG; pfam04740 169963003756 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 169963003757 MMPL family; Region: MMPL; cl14618 169963003758 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 169963003759 ligand binding site [chemical binding]; other site 169963003760 active site 169963003761 UGI interface [polypeptide binding]; other site 169963003762 catalytic site [active] 169963003763 ribonuclease HIII; Provisional; Region: PRK00996 169963003764 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 169963003765 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 169963003766 RNA/DNA hybrid binding site [nucleotide binding]; other site 169963003767 active site 169963003768 Cell division protein ZapA; Region: ZapA; cl01146 169963003769 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 169963003770 hypothetical protein; Provisional; Region: PRK08609 169963003771 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 169963003772 active site 169963003773 primer binding site [nucleotide binding]; other site 169963003774 NTP binding site [chemical binding]; other site 169963003775 metal binding triad [ion binding]; metal-binding site 169963003776 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 169963003777 active site 169963003778 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 169963003779 MutS domain III; Region: MutS_III; pfam05192 169963003780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963003781 Walker A/P-loop; other site 169963003782 ATP binding site [chemical binding]; other site 169963003783 Q-loop/lid; other site 169963003784 ABC transporter signature motif; other site 169963003785 Walker B; other site 169963003786 D-loop; other site 169963003787 H-loop/switch region; other site 169963003788 Smr domain; Region: Smr; pfam01713 169963003789 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963003790 catalytic residues [active] 169963003791 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 169963003792 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 169963003793 GIY-YIG motif/motif A; other site 169963003794 active site 169963003795 catalytic site [active] 169963003796 putative DNA binding site [nucleotide binding]; other site 169963003797 metal binding site [ion binding]; metal-binding site 169963003798 UvrB/uvrC motif; Region: UVR; pfam02151 169963003799 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 169963003800 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 169963003801 aspartate kinase; Reviewed; Region: PRK06635 169963003802 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 169963003803 putative nucleotide binding site [chemical binding]; other site 169963003804 putative catalytic residues [active] 169963003805 putative Mg ion binding site [ion binding]; other site 169963003806 putative aspartate binding site [chemical binding]; other site 169963003807 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 169963003808 putative allosteric regulatory site; other site 169963003809 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 169963003810 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 169963003811 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 169963003812 ribonuclease PH; Reviewed; Region: rph; PRK00173 169963003813 Ribonuclease PH; Region: RNase_PH_bact; cd11362 169963003814 hexamer interface [polypeptide binding]; other site 169963003815 active site 169963003816 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 169963003817 active site 169963003818 dimerization interface [polypeptide binding]; other site 169963003819 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 169963003820 active site 169963003821 metal binding site [ion binding]; metal-binding site 169963003822 homotetramer interface [polypeptide binding]; other site 169963003823 Uncharacterized conserved protein [Function unknown]; Region: COG5361 169963003824 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 169963003825 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 169963003826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 169963003827 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 169963003828 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 169963003829 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 169963003830 dimer interface [polypeptide binding]; other site 169963003831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963003832 catalytic core [active] 169963003833 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 169963003834 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 169963003835 ATP binding site [chemical binding]; other site 169963003836 Mg++ binding site [ion binding]; other site 169963003837 motif III; other site 169963003838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963003839 nucleotide binding region [chemical binding]; other site 169963003840 ATP-binding site [chemical binding]; other site 169963003841 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 169963003842 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 169963003843 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 169963003844 putative active site [active] 169963003845 nucleotide binding site [chemical binding]; other site 169963003846 nudix motif; other site 169963003847 putative metal binding site [ion binding]; other site 169963003848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963003849 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963003850 putative substrate translocation pore; other site 169963003851 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963003852 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963003853 ligand binding site [chemical binding]; other site 169963003854 flexible hinge region; other site 169963003855 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963003856 Uncharacterized conserved protein [Function unknown]; Region: COG1284 169963003857 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963003858 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963003859 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 169963003860 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 169963003861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963003862 DNA-binding site [nucleotide binding]; DNA binding site 169963003863 UTRA domain; Region: UTRA; pfam07702 169963003864 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 169963003865 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 169963003866 Ca binding site [ion binding]; other site 169963003867 active site 169963003868 catalytic site [active] 169963003869 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 169963003870 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963003871 active site turn [active] 169963003872 phosphorylation site [posttranslational modification] 169963003873 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963003874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 169963003875 nudix motif; other site 169963003876 Protein of unknown function (DUF877); Region: DUF877; cl05484 169963003877 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 169963003878 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 169963003879 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963003880 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 169963003881 putative catalytic cysteine [active] 169963003882 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 169963003883 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 169963003884 nucleotide binding site [chemical binding]; other site 169963003885 homotetrameric interface [polypeptide binding]; other site 169963003886 putative phosphate binding site [ion binding]; other site 169963003887 putative allosteric binding site; other site 169963003888 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 169963003889 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 169963003890 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963003891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963003892 non-specific DNA binding site [nucleotide binding]; other site 169963003893 salt bridge; other site 169963003894 sequence-specific DNA binding site [nucleotide binding]; other site 169963003895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963003896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963003897 non-specific DNA binding site [nucleotide binding]; other site 169963003898 salt bridge; other site 169963003899 sequence-specific DNA binding site [nucleotide binding]; other site 169963003900 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 169963003901 active site 169963003902 trigger factor; Provisional; Region: tig; PRK01490 169963003903 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 169963003904 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 169963003905 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 169963003906 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 169963003907 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 169963003908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963003909 Walker A motif; other site 169963003910 ATP binding site [chemical binding]; other site 169963003911 Walker B motif; other site 169963003912 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 169963003913 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 169963003914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 169963003915 Catalytic site [active] 169963003916 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 169963003917 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 169963003918 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 169963003919 Catalytic site [active] 169963003920 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 169963003921 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 169963003922 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 169963003923 Catalytic site [active] 169963003924 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 169963003925 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 169963003926 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 169963003927 GTP/Mg2+ binding site [chemical binding]; other site 169963003928 G4 box; other site 169963003929 G5 box; other site 169963003930 G1 box; other site 169963003931 Switch I region; other site 169963003932 G2 box; other site 169963003933 G3 box; other site 169963003934 Switch II region; other site 169963003935 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 169963003936 RNA/DNA hybrid binding site [nucleotide binding]; other site 169963003937 active site 169963003938 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 169963003939 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 169963003940 DNA topoisomerase I; Validated; Region: PRK05582 169963003941 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 169963003942 active site 169963003943 interdomain interaction site; other site 169963003944 putative metal-binding site [ion binding]; other site 169963003945 nucleotide binding site [chemical binding]; other site 169963003946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 169963003947 domain I; other site 169963003948 DNA binding groove [nucleotide binding] 169963003949 phosphate binding site [ion binding]; other site 169963003950 domain II; other site 169963003951 domain III; other site 169963003952 nucleotide binding site [chemical binding]; other site 169963003953 catalytic site [active] 169963003954 domain IV; other site 169963003955 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 169963003956 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 169963003957 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 169963003958 Glucose inhibited division protein A; Region: GIDA; pfam01134 169963003959 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 169963003960 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 169963003961 active site 169963003962 DNA binding site [nucleotide binding] 169963003963 Int/Topo IB signature motif; other site 169963003964 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 169963003965 active site 169963003966 HslU subunit interaction site [polypeptide binding]; other site 169963003967 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 169963003968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963003969 Walker A motif; other site 169963003970 ATP binding site [chemical binding]; other site 169963003971 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 169963003972 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 169963003973 transcriptional repressor CodY; Validated; Region: PRK04158 169963003974 CodY GAF-like domain; Region: CodY; pfam06018 169963003975 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 169963003976 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 169963003977 active site 169963003978 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 169963003979 active site 169963003980 catalytic residues [active] 169963003981 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 169963003982 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 169963003983 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 169963003984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963003985 ATP binding site [chemical binding]; other site 169963003986 Mg2+ binding site [ion binding]; other site 169963003987 G-X-G motif; other site 169963003988 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 169963003989 anchoring element; other site 169963003990 dimer interface [polypeptide binding]; other site 169963003991 ATP binding site [chemical binding]; other site 169963003992 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 169963003993 active site 169963003994 metal binding site [ion binding]; metal-binding site 169963003995 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 169963003996 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 169963003997 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 169963003998 CAP-like domain; other site 169963003999 active site 169963004000 primary dimer interface [polypeptide binding]; other site 169963004001 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963004002 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 169963004003 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 169963004004 Leucine rich repeat; Region: LRR_8; pfam13855 169963004005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963004006 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963004007 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963004008 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 169963004009 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 169963004010 catalytic triad [active] 169963004011 catalytic triad [active] 169963004012 oxyanion hole [active] 169963004013 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 169963004014 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 169963004015 active site 169963004016 catalytic site [active] 169963004017 metal binding site [ion binding]; metal-binding site 169963004018 dimer interface [polypeptide binding]; other site 169963004019 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 169963004020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963004021 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 169963004022 bacterial Hfq-like; Region: Hfq; cd01716 169963004023 hexamer interface [polypeptide binding]; other site 169963004024 Sm1 motif; other site 169963004025 RNA binding site [nucleotide binding]; other site 169963004026 Sm2 motif; other site 169963004027 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 169963004028 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 169963004029 HflX GTPase family; Region: HflX; cd01878 169963004030 G1 box; other site 169963004031 GTP/Mg2+ binding site [chemical binding]; other site 169963004032 Switch I region; other site 169963004033 G2 box; other site 169963004034 G3 box; other site 169963004035 Switch II region; other site 169963004036 G4 box; other site 169963004037 G5 box; other site 169963004038 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 169963004039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963004040 catalytic residue [active] 169963004041 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 169963004042 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963004043 DNA binding residues [nucleotide binding] 169963004044 putative dimer interface [polypeptide binding]; other site 169963004045 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 169963004046 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 169963004047 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 169963004048 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 169963004049 transmembrane helices; other site 169963004050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 169963004051 LexA repressor; Validated; Region: PRK00215 169963004052 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963004053 putative DNA binding site [nucleotide binding]; other site 169963004054 putative Zn2+ binding site [ion binding]; other site 169963004055 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 169963004056 Catalytic site [active] 169963004057 cell division suppressor protein YneA; Provisional; Region: PRK14125 169963004058 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 169963004059 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 169963004060 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 169963004061 TPP-binding site [chemical binding]; other site 169963004062 dimer interface [polypeptide binding]; other site 169963004063 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 169963004064 PYR/PP interface [polypeptide binding]; other site 169963004065 dimer interface [polypeptide binding]; other site 169963004066 TPP binding site [chemical binding]; other site 169963004067 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963004068 hypothetical protein; Provisional; Region: PRK01844 169963004069 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 169963004070 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 169963004071 Methyltransferase domain; Region: Methyltransf_31; pfam13847 169963004072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963004073 S-adenosylmethionine binding site [chemical binding]; other site 169963004074 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 169963004075 ParB-like nuclease domain; Region: ParBc; pfam02195 169963004076 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 169963004077 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 169963004078 Active Sites [active] 169963004079 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 169963004080 DEAD-like helicases superfamily; Region: DEXDc; smart00487 169963004081 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963004082 ATP binding site [chemical binding]; other site 169963004083 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 169963004084 putative Mg++ binding site [ion binding]; other site 169963004085 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 169963004086 putative nucleotide binding site [chemical binding]; other site 169963004087 uridine monophosphate binding site [chemical binding]; other site 169963004088 homohexameric interface [polypeptide binding]; other site 169963004089 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 169963004090 hinge region; other site 169963004091 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 169963004092 active site 169963004093 dimer interface [polypeptide binding]; other site 169963004094 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 169963004095 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 169963004096 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 169963004097 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 169963004098 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 169963004099 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 169963004100 RIP metalloprotease RseP; Region: TIGR00054 169963004101 active site 169963004102 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 169963004103 protein binding site [polypeptide binding]; other site 169963004104 putative substrate binding region [chemical binding]; other site 169963004105 prolyl-tRNA synthetase; Provisional; Region: PRK09194 169963004106 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 169963004107 dimer interface [polypeptide binding]; other site 169963004108 motif 1; other site 169963004109 active site 169963004110 motif 2; other site 169963004111 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 169963004112 putative deacylase active site [active] 169963004113 motif 3; other site 169963004114 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 169963004115 anticodon binding site; other site 169963004116 DNA polymerase III PolC; Validated; Region: polC; PRK00448 169963004117 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 169963004118 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 169963004119 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 169963004120 generic binding surface II; other site 169963004121 generic binding surface I; other site 169963004122 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 169963004123 active site 169963004124 putative PHP Thumb interface [polypeptide binding]; other site 169963004125 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 169963004126 active site 169963004127 catalytic site [active] 169963004128 substrate binding site [chemical binding]; other site 169963004129 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 169963004130 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 169963004131 Sm and related proteins; Region: Sm_like; cl00259 169963004132 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 169963004133 putative oligomer interface [polypeptide binding]; other site 169963004134 putative RNA binding site [nucleotide binding]; other site 169963004135 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 169963004136 NusA N-terminal domain; Region: NusA_N; pfam08529 169963004137 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 169963004138 RNA binding site [nucleotide binding]; other site 169963004139 homodimer interface [polypeptide binding]; other site 169963004140 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 169963004141 G-X-X-G motif; other site 169963004142 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 169963004143 G-X-X-G motif; other site 169963004144 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 169963004145 putative RNA binding cleft [nucleotide binding]; other site 169963004146 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 169963004147 translation initiation factor IF-2; Validated; Region: infB; PRK05306 169963004148 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 169963004149 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 169963004150 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 169963004151 G1 box; other site 169963004152 putative GEF interaction site [polypeptide binding]; other site 169963004153 GTP/Mg2+ binding site [chemical binding]; other site 169963004154 Switch I region; other site 169963004155 G2 box; other site 169963004156 G3 box; other site 169963004157 Switch II region; other site 169963004158 G4 box; other site 169963004159 G5 box; other site 169963004160 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 169963004161 Translation-initiation factor 2; Region: IF-2; pfam11987 169963004162 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 169963004163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 169963004164 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 169963004165 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 169963004166 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 169963004167 RNA binding site [nucleotide binding]; other site 169963004168 active site 169963004169 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 169963004170 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 169963004171 active site 169963004172 Riboflavin kinase; Region: Flavokinase; smart00904 169963004173 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 169963004174 16S/18S rRNA binding site [nucleotide binding]; other site 169963004175 S13e-L30e interaction site [polypeptide binding]; other site 169963004176 25S rRNA binding site [nucleotide binding]; other site 169963004177 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 169963004178 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 169963004179 RNase E interface [polypeptide binding]; other site 169963004180 trimer interface [polypeptide binding]; other site 169963004181 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 169963004182 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 169963004183 RNase E interface [polypeptide binding]; other site 169963004184 trimer interface [polypeptide binding]; other site 169963004185 active site 169963004186 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 169963004187 putative nucleic acid binding region [nucleotide binding]; other site 169963004188 G-X-X-G motif; other site 169963004189 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 169963004190 RNA binding site [nucleotide binding]; other site 169963004191 domain interface; other site 169963004192 GTPase RsgA; Reviewed; Region: PRK01889 169963004193 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 169963004194 RNA binding site [nucleotide binding]; other site 169963004195 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 169963004196 GTPase/Zn-binding domain interface [polypeptide binding]; other site 169963004197 GTP/Mg2+ binding site [chemical binding]; other site 169963004198 G4 box; other site 169963004199 G5 box; other site 169963004200 G1 box; other site 169963004201 Switch I region; other site 169963004202 G2 box; other site 169963004203 G3 box; other site 169963004204 Switch II region; other site 169963004205 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 169963004206 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 169963004207 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 169963004208 Rhomboid family; Region: Rhomboid; pfam01694 169963004209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963004210 TPR motif; other site 169963004211 TPR repeat; Region: TPR_11; pfam13414 169963004212 binding surface 169963004213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 169963004214 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 169963004215 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963004216 nucleotide binding site [chemical binding]; other site 169963004217 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 169963004218 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 169963004219 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 169963004220 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 169963004221 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 169963004222 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 169963004223 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 169963004224 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 169963004225 Walker A motif; other site 169963004226 ATP binding site [chemical binding]; other site 169963004227 Walker B motif; other site 169963004228 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 169963004229 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 169963004230 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 169963004231 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 169963004232 tetramer interface [polypeptide binding]; other site 169963004233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963004234 catalytic residue [active] 169963004235 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 169963004236 tetramer interface [polypeptide binding]; other site 169963004237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963004238 catalytic residue [active] 169963004239 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 169963004240 active site residue [active] 169963004241 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 169963004242 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 169963004243 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 169963004244 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 169963004245 active site 169963004246 elongation factor P; Validated; Region: PRK00529 169963004247 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 169963004248 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 169963004249 RNA binding site [nucleotide binding]; other site 169963004250 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 169963004251 RNA binding site [nucleotide binding]; other site 169963004252 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 169963004253 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 169963004254 carboxyltransferase (CT) interaction site; other site 169963004255 biotinylation site [posttranslational modification]; other site 169963004256 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 169963004257 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 169963004258 ATP-grasp domain; Region: ATP-grasp_4; cl17255 169963004259 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 169963004260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 169963004261 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 169963004262 putative RNA binding site [nucleotide binding]; other site 169963004263 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 169963004264 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 169963004265 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 169963004266 homodimer interface [polypeptide binding]; other site 169963004267 NADP binding site [chemical binding]; other site 169963004268 substrate binding site [chemical binding]; other site 169963004269 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 169963004270 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 169963004271 generic binding surface II; other site 169963004272 generic binding surface I; other site 169963004273 Domain of unknown function (DUF1704); Region: DUF1704; cl06858 169963004274 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 169963004275 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 169963004276 substrate binding pocket [chemical binding]; other site 169963004277 chain length determination region; other site 169963004278 substrate-Mg2+ binding site; other site 169963004279 catalytic residues [active] 169963004280 aspartate-rich region 1; other site 169963004281 active site lid residues [active] 169963004282 aspartate-rich region 2; other site 169963004283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 169963004284 DNA-binding site [nucleotide binding]; DNA binding site 169963004285 RNA-binding motif; other site 169963004286 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 169963004287 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 169963004288 TPP-binding site; other site 169963004289 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 169963004290 PYR/PP interface [polypeptide binding]; other site 169963004291 dimer interface [polypeptide binding]; other site 169963004292 TPP binding site [chemical binding]; other site 169963004293 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963004294 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 169963004295 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963004296 RNA binding surface [nucleotide binding]; other site 169963004297 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 169963004298 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 169963004299 arginine repressor; Provisional; Region: PRK04280 169963004300 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 169963004301 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 169963004302 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 169963004303 Walker A/P-loop; other site 169963004304 ATP binding site [chemical binding]; other site 169963004305 Q-loop/lid; other site 169963004306 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 169963004307 Q-loop/lid; other site 169963004308 ABC transporter signature motif; other site 169963004309 Walker B; other site 169963004310 D-loop; other site 169963004311 H-loop/switch region; other site 169963004312 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 169963004313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963004314 nucleotide binding site [chemical binding]; other site 169963004315 Acetokinase family; Region: Acetate_kinase; cl17229 169963004316 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 169963004317 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963004318 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963004319 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 169963004320 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 169963004321 tetramer interface [polypeptide binding]; other site 169963004322 TPP-binding site [chemical binding]; other site 169963004323 heterodimer interface [polypeptide binding]; other site 169963004324 phosphorylation loop region [posttranslational modification] 169963004325 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 169963004326 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 169963004327 alpha subunit interface [polypeptide binding]; other site 169963004328 TPP binding site [chemical binding]; other site 169963004329 heterodimer interface [polypeptide binding]; other site 169963004330 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963004331 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 169963004332 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 169963004333 E3 interaction surface; other site 169963004334 lipoyl attachment site [posttranslational modification]; other site 169963004335 e3 binding domain; Region: E3_binding; pfam02817 169963004336 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 169963004337 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 169963004338 peptidase T-like protein; Region: PepT-like; TIGR01883 169963004339 metal binding site [ion binding]; metal-binding site 169963004340 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 169963004341 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 169963004342 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 169963004343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963004344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963004345 active site 169963004346 phosphorylation site [posttranslational modification] 169963004347 intermolecular recognition site; other site 169963004348 dimerization interface [polypeptide binding]; other site 169963004349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963004350 DNA binding site [nucleotide binding] 169963004351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 169963004352 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963004353 dimerization interface [polypeptide binding]; other site 169963004354 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963004355 dimer interface [polypeptide binding]; other site 169963004356 phosphorylation site [posttranslational modification] 169963004357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963004358 ATP binding site [chemical binding]; other site 169963004359 Mg2+ binding site [ion binding]; other site 169963004360 G-X-G motif; other site 169963004361 OxaA-like protein precursor; Validated; Region: PRK01622 169963004362 acylphosphatase; Provisional; Region: PRK14443 169963004363 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 169963004364 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 169963004365 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 169963004366 homotetramer interface [polypeptide binding]; other site 169963004367 FMN binding site [chemical binding]; other site 169963004368 homodimer contacts [polypeptide binding]; other site 169963004369 putative active site [active] 169963004370 putative substrate binding site [chemical binding]; other site 169963004371 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 169963004372 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 169963004373 active site residue [active] 169963004374 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 169963004375 Uncharacterized conserved protein [Function unknown]; Region: COG1284 169963004376 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963004377 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963004378 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 169963004379 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 169963004380 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 169963004381 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 169963004382 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 169963004383 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 169963004384 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 169963004385 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 169963004386 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 169963004387 ligand binding site [chemical binding]; other site 169963004388 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 169963004389 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 169963004390 Walker A/P-loop; other site 169963004391 ATP binding site [chemical binding]; other site 169963004392 Q-loop/lid; other site 169963004393 ABC transporter signature motif; other site 169963004394 Walker B; other site 169963004395 D-loop; other site 169963004396 H-loop/switch region; other site 169963004397 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 169963004398 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 169963004399 TM-ABC transporter signature motif; other site 169963004400 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 169963004401 TM-ABC transporter signature motif; other site 169963004402 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 169963004403 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 169963004404 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 169963004405 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 169963004406 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 169963004407 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 169963004408 classical (c) SDRs; Region: SDR_c; cd05233 169963004409 NAD(P) binding site [chemical binding]; other site 169963004410 active site 169963004411 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 169963004412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963004413 non-specific DNA binding site [nucleotide binding]; other site 169963004414 salt bridge; other site 169963004415 sequence-specific DNA binding site [nucleotide binding]; other site 169963004416 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 169963004417 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 169963004418 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 169963004419 competence damage-inducible protein A; Provisional; Region: PRK00549 169963004420 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 169963004421 putative MPT binding site; other site 169963004422 Competence-damaged protein; Region: CinA; pfam02464 169963004423 recombinase A; Provisional; Region: recA; PRK09354 169963004424 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 169963004425 hexamer interface [polypeptide binding]; other site 169963004426 Walker A motif; other site 169963004427 ATP binding site [chemical binding]; other site 169963004428 Walker B motif; other site 169963004429 phosphodiesterase; Provisional; Region: PRK12704 169963004430 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 169963004431 KH domain; Region: KH_1; pfam00013 169963004432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963004433 Zn2+ binding site [ion binding]; other site 169963004434 Mg2+ binding site [ion binding]; other site 169963004435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963004436 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 169963004437 Coenzyme A binding pocket [chemical binding]; other site 169963004438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963004439 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 169963004440 putative active site [active] 169963004441 metal binding site [ion binding]; metal-binding site 169963004442 homodimer binding site [polypeptide binding]; other site 169963004443 Predicted membrane protein [Function unknown]; Region: COG4550 169963004444 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 169963004445 MutS domain I; Region: MutS_I; pfam01624 169963004446 MutS domain II; Region: MutS_II; pfam05188 169963004447 MutS domain III; Region: MutS_III; pfam05192 169963004448 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 169963004449 Walker A/P-loop; other site 169963004450 ATP binding site [chemical binding]; other site 169963004451 Q-loop/lid; other site 169963004452 ABC transporter signature motif; other site 169963004453 Walker B; other site 169963004454 D-loop; other site 169963004455 H-loop/switch region; other site 169963004456 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 169963004457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963004458 ATP binding site [chemical binding]; other site 169963004459 Mg2+ binding site [ion binding]; other site 169963004460 G-X-G motif; other site 169963004461 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 169963004462 ATP binding site [chemical binding]; other site 169963004463 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 169963004464 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 169963004465 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 169963004466 Pyruvate formate lyase 1; Region: PFL1; cd01678 169963004467 coenzyme A binding site [chemical binding]; other site 169963004468 active site 169963004469 catalytic residues [active] 169963004470 glycine loop; other site 169963004471 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 169963004472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 169963004473 FeS/SAM binding site; other site 169963004474 Predicted transcriptional regulators [Transcription]; Region: COG1695 169963004475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963004476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963004477 putative substrate translocation pore; other site 169963004478 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 169963004479 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963004480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963004481 non-specific DNA binding site [nucleotide binding]; other site 169963004482 salt bridge; other site 169963004483 sequence-specific DNA binding site [nucleotide binding]; other site 169963004484 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 169963004485 AAA domain; Region: AAA_17; cl19128 169963004486 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963004487 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963004488 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963004489 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963004490 putative acyltransferase; Provisional; Region: PRK05790 169963004491 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 169963004492 dimer interface [polypeptide binding]; other site 169963004493 active site 169963004494 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 169963004495 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 169963004496 dimer interface [polypeptide binding]; other site 169963004497 active site 169963004498 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 169963004499 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 169963004500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963004501 putative substrate translocation pore; other site 169963004502 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 169963004503 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 169963004504 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 169963004505 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 169963004506 FAD binding domain; Region: FAD_binding_4; pfam01565 169963004507 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 169963004508 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 169963004509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963004510 Walker A/P-loop; other site 169963004511 ATP binding site [chemical binding]; other site 169963004512 Q-loop/lid; other site 169963004513 ABC transporter signature motif; other site 169963004514 Walker B; other site 169963004515 D-loop; other site 169963004516 H-loop/switch region; other site 169963004517 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 169963004518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963004519 dimer interface [polypeptide binding]; other site 169963004520 conserved gate region; other site 169963004521 putative PBP binding loops; other site 169963004522 ABC-ATPase subunit interface; other site 169963004523 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 169963004524 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 169963004525 manganese transport protein MntH; Reviewed; Region: PRK00701 169963004526 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 169963004527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963004528 ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism]; Region: ArtM; COG4160 169963004529 dimer interface [polypeptide binding]; other site 169963004530 conserved gate region; other site 169963004531 putative PBP binding loops; other site 169963004532 ABC-ATPase subunit interface; other site 169963004533 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 169963004534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963004535 dimer interface [polypeptide binding]; other site 169963004536 conserved gate region; other site 169963004537 putative PBP binding loops; other site 169963004538 ABC-ATPase subunit interface; other site 169963004539 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 169963004540 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 169963004541 Walker A/P-loop; other site 169963004542 ATP binding site [chemical binding]; other site 169963004543 Q-loop/lid; other site 169963004544 ABC transporter signature motif; other site 169963004545 Walker B; other site 169963004546 D-loop; other site 169963004547 H-loop/switch region; other site 169963004548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 169963004549 Predicted membrane protein [Function unknown]; Region: COG3859 169963004550 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 169963004551 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 169963004552 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963004553 ABC transporter; Region: ABC_tran_2; pfam12848 169963004554 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963004555 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 169963004556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963004557 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963004558 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 169963004559 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 169963004560 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 169963004561 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 169963004562 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 169963004563 dimer interface [polypeptide binding]; other site 169963004564 active site 169963004565 catalytic residue [active] 169963004566 aspartate kinase I; Reviewed; Region: PRK08210 169963004567 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 169963004568 nucleotide binding site [chemical binding]; other site 169963004569 substrate binding site [chemical binding]; other site 169963004570 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 169963004571 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 169963004572 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 169963004573 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 169963004574 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 169963004575 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 169963004576 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 169963004577 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 169963004578 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 169963004579 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 169963004580 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 169963004581 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 169963004582 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 169963004583 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 169963004584 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 169963004585 Predicted membrane protein [Function unknown]; Region: COG4392 169963004586 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 169963004587 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 169963004588 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 169963004589 metal binding site 2 [ion binding]; metal-binding site 169963004590 putative DNA binding helix; other site 169963004591 metal binding site 1 [ion binding]; metal-binding site 169963004592 dimer interface [polypeptide binding]; other site 169963004593 structural Zn2+ binding site [ion binding]; other site 169963004594 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963004595 ABC-ATPase subunit interface; other site 169963004596 dimer interface [polypeptide binding]; other site 169963004597 putative PBP binding regions; other site 169963004598 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 169963004599 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 169963004600 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 169963004601 DHH family; Region: DHH; pfam01368 169963004602 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 169963004603 DHHA2 domain; Region: DHHA2; pfam02833 169963004604 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 169963004605 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 169963004606 AP (apurinic/apyrimidinic) site pocket; other site 169963004607 DNA interaction; other site 169963004608 Metal-binding active site; metal-binding site 169963004609 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 169963004610 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 169963004611 ATP binding site [chemical binding]; other site 169963004612 Mg++ binding site [ion binding]; other site 169963004613 motif III; other site 169963004614 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963004615 nucleotide binding region [chemical binding]; other site 169963004616 ATP-binding site [chemical binding]; other site 169963004617 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 169963004618 Fe-S cluster binding site [ion binding]; other site 169963004619 substrate binding site [chemical binding]; other site 169963004620 catalytic site [active] 169963004621 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 169963004622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 169963004623 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 169963004624 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 169963004625 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 169963004626 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 169963004627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 169963004628 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 169963004629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 169963004630 DNA binding residues [nucleotide binding] 169963004631 DNA primase; Validated; Region: dnaG; PRK05667 169963004632 CHC2 zinc finger; Region: zf-CHC2; pfam01807 169963004633 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 169963004634 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 169963004635 active site 169963004636 metal binding site [ion binding]; metal-binding site 169963004637 interdomain interaction site; other site 169963004638 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 169963004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 169963004640 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 169963004641 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 169963004642 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 169963004643 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 169963004644 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 169963004645 dimer interface [polypeptide binding]; other site 169963004646 motif 1; other site 169963004647 active site 169963004648 motif 2; other site 169963004649 motif 3; other site 169963004650 Recombination protein O N terminal; Region: RecO_N; pfam11967 169963004651 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 169963004652 Recombination protein O C terminal; Region: RecO_C; pfam02565 169963004653 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 169963004654 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 169963004655 GTPase Era; Reviewed; Region: era; PRK00089 169963004656 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 169963004657 G1 box; other site 169963004658 GTP/Mg2+ binding site [chemical binding]; other site 169963004659 Switch I region; other site 169963004660 G2 box; other site 169963004661 Switch II region; other site 169963004662 G3 box; other site 169963004663 G4 box; other site 169963004664 G5 box; other site 169963004665 KH domain; Region: KH_2; pfam07650 169963004666 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 169963004667 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 169963004668 active site 169963004669 catalytic motif [active] 169963004670 Zn binding site [ion binding]; other site 169963004671 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 169963004672 trimer interface [polypeptide binding]; other site 169963004673 putative active site [active] 169963004674 Zn binding site [ion binding]; other site 169963004675 metal-binding heat shock protein; Provisional; Region: PRK00016 169963004676 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 169963004677 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 169963004678 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 169963004679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963004680 Zn2+ binding site [ion binding]; other site 169963004681 Mg2+ binding site [ion binding]; other site 169963004682 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 169963004683 PhoH-like protein; Region: PhoH; pfam02562 169963004684 Yqey-like protein; Region: YqeY; pfam09424 169963004685 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 169963004686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 169963004687 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 169963004688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963004689 S-adenosylmethionine binding site [chemical binding]; other site 169963004690 chaperone protein DnaJ; Provisional; Region: PRK14280 169963004691 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 169963004692 HSP70 interaction site [polypeptide binding]; other site 169963004693 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 169963004694 substrate binding site [polypeptide binding]; other site 169963004695 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 169963004696 Zn binding sites [ion binding]; other site 169963004697 dimer interface [polypeptide binding]; other site 169963004698 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 169963004699 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 169963004700 nucleotide binding site [chemical binding]; other site 169963004701 NEF interaction site [polypeptide binding]; other site 169963004702 SBD interface [polypeptide binding]; other site 169963004703 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 169963004704 dimer interface [polypeptide binding]; other site 169963004705 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 169963004706 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 169963004707 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 169963004708 HrcA protein C terminal domain; Region: HrcA; pfam01628 169963004709 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 169963004710 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 169963004711 FeS/SAM binding site; other site 169963004712 HemN C-terminal domain; Region: HemN_C; pfam06969 169963004713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 169963004714 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 169963004715 NADP binding site [chemical binding]; other site 169963004716 putative substrate binding site [chemical binding]; other site 169963004717 active site 169963004718 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963004719 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963004720 DNA binding residues [nucleotide binding] 169963004721 putative dimer interface [polypeptide binding]; other site 169963004722 GTP-binding protein LepA; Provisional; Region: PRK05433 169963004723 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 169963004724 G1 box; other site 169963004725 putative GEF interaction site [polypeptide binding]; other site 169963004726 GTP/Mg2+ binding site [chemical binding]; other site 169963004727 Switch I region; other site 169963004728 G2 box; other site 169963004729 G3 box; other site 169963004730 Switch II region; other site 169963004731 G4 box; other site 169963004732 G5 box; other site 169963004733 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 169963004734 Elongation Factor G, domain II; Region: EFG_II; pfam14492 169963004735 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 169963004736 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 169963004737 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 169963004738 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 169963004739 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 169963004740 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 169963004741 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 169963004742 Competence protein; Region: Competence; pfam03772 169963004743 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 169963004744 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 169963004745 catalytic motif [active] 169963004746 Zn binding site [ion binding]; other site 169963004747 SLBB domain; Region: SLBB; pfam10531 169963004748 comEA protein; Region: comE; TIGR01259 169963004749 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 169963004750 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 169963004751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963004752 S-adenosylmethionine binding site [chemical binding]; other site 169963004753 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 169963004754 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963004755 Zn2+ binding site [ion binding]; other site 169963004756 Mg2+ binding site [ion binding]; other site 169963004757 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 169963004758 active site 169963004759 (T/H)XGH motif; other site 169963004760 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 169963004761 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 169963004762 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 169963004763 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 169963004764 shikimate binding site; other site 169963004765 NAD(P) binding site [chemical binding]; other site 169963004766 GTPase YqeH; Provisional; Region: PRK13796 169963004767 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 169963004768 GTP/Mg2+ binding site [chemical binding]; other site 169963004769 G4 box; other site 169963004770 G5 box; other site 169963004771 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 169963004772 G1 box; other site 169963004773 G1 box; other site 169963004774 GTP/Mg2+ binding site [chemical binding]; other site 169963004775 G2 box; other site 169963004776 Switch I region; other site 169963004777 G2 box; other site 169963004778 Switch I region; other site 169963004779 G3 box; other site 169963004780 G3 box; other site 169963004781 Switch II region; other site 169963004782 Switch II region; other site 169963004783 G4 box; other site 169963004784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963004785 active site 169963004786 motif I; other site 169963004787 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 169963004788 motif II; other site 169963004789 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 169963004790 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 169963004791 active site 169963004792 Zn binding site [ion binding]; other site 169963004793 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 169963004794 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 169963004795 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 169963004796 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 169963004797 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 169963004798 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 169963004799 ATP-binding site [chemical binding]; other site 169963004800 Sugar specificity; other site 169963004801 Pyrimidine base specificity; other site 169963004802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963004803 S-adenosylmethionine binding site [chemical binding]; other site 169963004804 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 169963004805 dimerization interface [polypeptide binding]; other site 169963004806 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 169963004807 hypothetical protein; Provisional; Region: PRK13678 169963004808 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 169963004809 hypothetical protein; Provisional; Region: PRK05473 169963004810 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 169963004811 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 169963004812 motif 1; other site 169963004813 active site 169963004814 motif 2; other site 169963004815 motif 3; other site 169963004816 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 169963004817 DHHA1 domain; Region: DHHA1; pfam02272 169963004818 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963004819 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963004820 Walker A/P-loop; other site 169963004821 ATP binding site [chemical binding]; other site 169963004822 Q-loop/lid; other site 169963004823 ABC transporter signature motif; other site 169963004824 Walker B; other site 169963004825 D-loop; other site 169963004826 H-loop/switch region; other site 169963004827 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963004828 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963004829 FtsX-like permease family; Region: FtsX; pfam02687 169963004830 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963004831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963004832 active site 169963004833 phosphorylation site [posttranslational modification] 169963004834 intermolecular recognition site; other site 169963004835 dimerization interface [polypeptide binding]; other site 169963004836 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963004837 DNA binding site [nucleotide binding] 169963004838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 169963004839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963004840 dimerization interface [polypeptide binding]; other site 169963004841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963004842 dimer interface [polypeptide binding]; other site 169963004843 phosphorylation site [posttranslational modification] 169963004844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963004845 ATP binding site [chemical binding]; other site 169963004846 Mg2+ binding site [ion binding]; other site 169963004847 G-X-G motif; other site 169963004848 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 169963004849 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 169963004850 AAA domain; Region: AAA_30; pfam13604 169963004851 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 169963004852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963004853 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 169963004854 TPR motif; other site 169963004855 binding surface 169963004856 TPR repeat; Region: TPR_11; pfam13414 169963004857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963004858 binding surface 169963004859 TPR motif; other site 169963004860 TPR repeat; Region: TPR_11; pfam13414 169963004861 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 169963004862 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 169963004863 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 169963004864 Ligand Binding Site [chemical binding]; other site 169963004865 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 169963004866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963004867 catalytic residue [active] 169963004868 recombination factor protein RarA; Reviewed; Region: PRK13342 169963004869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963004870 Walker A motif; other site 169963004871 ATP binding site [chemical binding]; other site 169963004872 Walker B motif; other site 169963004873 arginine finger; other site 169963004874 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 169963004875 Predicted transcriptional regulator [Transcription]; Region: COG1959 169963004876 Rrf2 family protein; Region: rrf2_super; TIGR00738 169963004877 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 169963004878 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 169963004879 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 169963004880 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 169963004881 dimer interface [polypeptide binding]; other site 169963004882 anticodon binding site; other site 169963004883 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 169963004884 homodimer interface [polypeptide binding]; other site 169963004885 motif 1; other site 169963004886 active site 169963004887 motif 2; other site 169963004888 GAD domain; Region: GAD; pfam02938 169963004889 motif 3; other site 169963004890 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 169963004891 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 169963004892 dimer interface [polypeptide binding]; other site 169963004893 motif 1; other site 169963004894 active site 169963004895 motif 2; other site 169963004896 motif 3; other site 169963004897 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 169963004898 anticodon binding site; other site 169963004899 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 169963004900 Bacterial SH3 domain; Region: SH3_3; pfam08239 169963004901 Bacterial SH3 domain; Region: SH3_3; pfam08239 169963004902 Bacterial SH3 domain homologues; Region: SH3b; smart00287 169963004903 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 169963004904 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 169963004905 active site 169963004906 metal binding site [ion binding]; metal-binding site 169963004907 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 169963004908 putative active site [active] 169963004909 dimerization interface [polypeptide binding]; other site 169963004910 putative tRNAtyr binding site [nucleotide binding]; other site 169963004911 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 169963004912 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963004913 Zn2+ binding site [ion binding]; other site 169963004914 Mg2+ binding site [ion binding]; other site 169963004915 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 169963004916 synthetase active site [active] 169963004917 NTP binding site [chemical binding]; other site 169963004918 metal binding site [ion binding]; metal-binding site 169963004919 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 169963004920 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 169963004921 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963004922 active site 169963004923 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 169963004924 DHH family; Region: DHH; pfam01368 169963004925 DHHA1 domain; Region: DHHA1; pfam02272 169963004926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 169963004927 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 169963004928 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 169963004929 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 169963004930 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 169963004931 Protein export membrane protein; Region: SecD_SecF; pfam02355 169963004932 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 169963004933 Preprotein translocase subunit; Region: YajC; pfam02699 169963004934 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 169963004935 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 169963004936 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 169963004937 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 169963004938 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963004939 Walker A motif; other site 169963004940 ATP binding site [chemical binding]; other site 169963004941 Walker B motif; other site 169963004942 arginine finger; other site 169963004943 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 169963004944 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 169963004945 RuvA N terminal domain; Region: RuvA_N; pfam01330 169963004946 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 169963004947 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 169963004948 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 169963004949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963004950 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 169963004951 NAD binding site [chemical binding]; other site 169963004952 dimer interface [polypeptide binding]; other site 169963004953 substrate binding site [chemical binding]; other site 169963004954 hypothetical protein; Validated; Region: PRK00110 169963004955 prephenate dehydratase; Provisional; Region: PRK11898 169963004956 Prephenate dehydratase; Region: PDT; pfam00800 169963004957 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 169963004958 putative L-Phe binding site [chemical binding]; other site 169963004959 GTPase CgtA; Reviewed; Region: obgE; PRK12297 169963004960 GTP1/OBG; Region: GTP1_OBG; pfam01018 169963004961 Obg GTPase; Region: Obg; cd01898 169963004962 G1 box; other site 169963004963 GTP/Mg2+ binding site [chemical binding]; other site 169963004964 Switch I region; other site 169963004965 G2 box; other site 169963004966 G3 box; other site 169963004967 Switch II region; other site 169963004968 G4 box; other site 169963004969 G5 box; other site 169963004970 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 169963004971 glycerol kinase; Provisional; Region: glpK; PRK00047 169963004972 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 169963004973 N- and C-terminal domain interface [polypeptide binding]; other site 169963004974 active site 169963004975 MgATP binding site [chemical binding]; other site 169963004976 catalytic site [active] 169963004977 metal binding site [ion binding]; metal-binding site 169963004978 glycerol binding site [chemical binding]; other site 169963004979 homotetramer interface [polypeptide binding]; other site 169963004980 homodimer interface [polypeptide binding]; other site 169963004981 FBP binding site [chemical binding]; other site 169963004982 protein IIAGlc interface [polypeptide binding]; other site 169963004983 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 169963004984 amphipathic channel; other site 169963004985 Asn-Pro-Ala signature motifs; other site 169963004986 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 169963004987 hypothetical protein; Provisional; Region: PRK14553 169963004988 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 169963004989 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 169963004990 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 169963004991 homodimer interface [polypeptide binding]; other site 169963004992 oligonucleotide binding site [chemical binding]; other site 169963004993 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 169963004994 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 169963004995 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 169963004996 P-loop; other site 169963004997 ADP binding residues [chemical binding]; other site 169963004998 Switch I; other site 169963004999 Switch II; other site 169963005000 septum formation inhibitor; Reviewed; Region: minC; PRK00513 169963005001 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 169963005002 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 169963005003 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 169963005004 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cd12193 169963005005 rod shape-determining protein MreB; Provisional; Region: PRK13927 169963005006 MreB and similar proteins; Region: MreB_like; cd10225 169963005007 nucleotide binding site [chemical binding]; other site 169963005008 Mg binding site [ion binding]; other site 169963005009 putative protofilament interaction site [polypeptide binding]; other site 169963005010 RodZ interaction site [polypeptide binding]; other site 169963005011 hypothetical protein; Reviewed; Region: PRK00024 169963005012 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 169963005013 MPN+ (JAMM) motif; other site 169963005014 Zinc-binding site [ion binding]; other site 169963005015 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 169963005016 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 169963005017 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 169963005018 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 169963005019 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 169963005020 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 169963005021 AAA domain; Region: AAA_14; pfam13173 169963005022 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 169963005023 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 169963005024 active site 169963005025 HIGH motif; other site 169963005026 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 169963005027 KMSKS motif; other site 169963005028 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 169963005029 tRNA binding surface [nucleotide binding]; other site 169963005030 anticodon binding site; other site 169963005031 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 169963005032 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 169963005033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 169963005034 inhibitor-cofactor binding pocket; inhibition site 169963005035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005036 catalytic residue [active] 169963005037 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 169963005038 dimer interface [polypeptide binding]; other site 169963005039 active site 169963005040 Schiff base residues; other site 169963005041 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 169963005042 active site 169963005043 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 169963005044 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 169963005045 domain interfaces; other site 169963005046 active site 169963005047 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 169963005048 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 169963005049 tRNA; other site 169963005050 putative tRNA binding site [nucleotide binding]; other site 169963005051 putative NADP binding site [chemical binding]; other site 169963005052 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 169963005053 Predicted GTPase [General function prediction only]; Region: COG0218 169963005054 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 169963005055 G1 box; other site 169963005056 GTP/Mg2+ binding site [chemical binding]; other site 169963005057 Switch I region; other site 169963005058 G2 box; other site 169963005059 G3 box; other site 169963005060 Switch II region; other site 169963005061 G4 box; other site 169963005062 G5 box; other site 169963005063 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 169963005064 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 169963005065 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 169963005066 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 169963005067 active site 169963005068 dimer interface [polypeptide binding]; other site 169963005069 motif 1; other site 169963005070 motif 2; other site 169963005071 motif 3; other site 169963005072 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 169963005073 anticodon binding site; other site 169963005074 primosomal protein DnaI; Reviewed; Region: PRK08939 169963005075 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 169963005076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963005077 Walker A motif; other site 169963005078 ATP binding site [chemical binding]; other site 169963005079 Walker B motif; other site 169963005080 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 169963005081 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 169963005082 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 169963005083 ATP cone domain; Region: ATP-cone; pfam03477 169963005084 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 169963005085 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 169963005086 CoA-binding site [chemical binding]; other site 169963005087 ATP-binding [chemical binding]; other site 169963005088 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 169963005089 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 169963005090 DNA binding site [nucleotide binding] 169963005091 catalytic residue [active] 169963005092 H2TH interface [polypeptide binding]; other site 169963005093 putative catalytic residues [active] 169963005094 turnover-facilitating residue; other site 169963005095 intercalation triad [nucleotide binding]; other site 169963005096 8OG recognition residue [nucleotide binding]; other site 169963005097 putative reading head residues; other site 169963005098 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 169963005099 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 169963005100 DNA polymerase I; Provisional; Region: PRK05755 169963005101 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 169963005102 active site 169963005103 metal binding site 1 [ion binding]; metal-binding site 169963005104 putative 5' ssDNA interaction site; other site 169963005105 metal binding site 3; metal-binding site 169963005106 metal binding site 2 [ion binding]; metal-binding site 169963005107 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 169963005108 putative DNA binding site [nucleotide binding]; other site 169963005109 putative metal binding site [ion binding]; other site 169963005110 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 169963005111 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 169963005112 active site 169963005113 DNA binding site [nucleotide binding] 169963005114 catalytic site [active] 169963005115 isocitrate dehydrogenase; Reviewed; Region: PRK07006 169963005116 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 169963005117 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 169963005118 dimer interface [polypeptide binding]; other site 169963005119 active site 169963005120 citrylCoA binding site [chemical binding]; other site 169963005121 oxalacetate/citrate binding site [chemical binding]; other site 169963005122 coenzyme A binding site [chemical binding]; other site 169963005123 catalytic triad [active] 169963005124 Protein of unknown function (DUF441); Region: DUF441; pfam04284 169963005125 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 169963005126 pyruvate kinase; Provisional; Region: PRK06354 169963005127 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 169963005128 domain interfaces; other site 169963005129 active site 169963005130 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 169963005131 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 169963005132 active site 169963005133 ADP/pyrophosphate binding site [chemical binding]; other site 169963005134 dimerization interface [polypeptide binding]; other site 169963005135 allosteric effector site; other site 169963005136 fructose-1,6-bisphosphate binding site; other site 169963005137 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 169963005138 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 169963005139 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 169963005140 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 169963005141 active site 169963005142 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 169963005143 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 169963005144 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 169963005145 generic binding surface I; other site 169963005146 generic binding surface II; other site 169963005147 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 169963005148 DHH family; Region: DHH; pfam01368 169963005149 DHHA1 domain; Region: DHHA1; pfam02272 169963005150 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 169963005151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 169963005152 DNA-binding site [nucleotide binding]; DNA binding site 169963005153 DRTGG domain; Region: DRTGG; pfam07085 169963005154 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 169963005155 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 169963005156 active site 2 [active] 169963005157 active site 1 [active] 169963005158 metal-dependent hydrolase; Provisional; Region: PRK00685 169963005159 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 169963005160 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 169963005161 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 169963005162 active site 169963005163 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 169963005164 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 169963005165 hexamer interface [polypeptide binding]; other site 169963005166 ligand binding site [chemical binding]; other site 169963005167 putative active site [active] 169963005168 NAD(P) binding site [chemical binding]; other site 169963005169 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 169963005170 Ligand Binding Site [chemical binding]; other site 169963005171 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 169963005172 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 169963005173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005174 S-adenosylmethionine binding site [chemical binding]; other site 169963005175 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 169963005176 dimer interface [polypeptide binding]; other site 169963005177 catalytic triad [active] 169963005178 peroxidatic and resolving cysteines [active] 169963005179 RDD family; Region: RDD; pfam06271 169963005180 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 169963005181 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 169963005182 tandem repeat interface [polypeptide binding]; other site 169963005183 oligomer interface [polypeptide binding]; other site 169963005184 active site residues [active] 169963005185 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 169963005186 ornithine carbamoyltransferase; Provisional; Region: PRK00779 169963005187 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 169963005188 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 169963005189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 169963005190 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 169963005191 inhibitor-cofactor binding pocket; inhibition site 169963005192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005193 catalytic residue [active] 169963005194 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 169963005195 nucleotide binding site [chemical binding]; other site 169963005196 N-acetyl-L-glutamate binding site [chemical binding]; other site 169963005197 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 169963005198 heterotetramer interface [polypeptide binding]; other site 169963005199 active site pocket [active] 169963005200 cleavage site 169963005201 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 169963005202 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 169963005203 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 169963005204 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 169963005205 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 169963005206 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 169963005207 Ligand Binding Site [chemical binding]; other site 169963005208 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 169963005209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963005210 catalytic residue [active] 169963005211 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 169963005212 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 169963005213 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 169963005214 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 169963005215 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963005216 RNA binding surface [nucleotide binding]; other site 169963005217 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 169963005218 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 169963005219 active site 169963005220 HIGH motif; other site 169963005221 dimer interface [polypeptide binding]; other site 169963005222 KMSKS motif; other site 169963005223 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963005224 RNA binding surface [nucleotide binding]; other site 169963005225 catabolite control protein A; Region: ccpA; TIGR01481 169963005226 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963005227 DNA binding site [nucleotide binding] 169963005228 domain linker motif; other site 169963005229 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 169963005230 dimerization interface [polypeptide binding]; other site 169963005231 effector binding site; other site 169963005232 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 169963005233 Chorismate mutase type II; Region: CM_2; cl00693 169963005234 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 169963005235 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 169963005236 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 169963005237 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 169963005238 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 169963005239 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 169963005240 dimer interface [polypeptide binding]; other site 169963005241 decamer (pentamer of dimers) interface [polypeptide binding]; other site 169963005242 catalytic triad [active] 169963005243 peroxidatic and resolving cysteines [active] 169963005244 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 169963005245 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 169963005246 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 169963005247 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 169963005248 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 169963005249 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 169963005250 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 169963005251 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 169963005252 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 169963005253 putative tRNA-binding site [nucleotide binding]; other site 169963005254 hypothetical protein; Provisional; Region: PRK13668 169963005255 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963005256 catalytic residues [active] 169963005257 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 169963005258 oligomer interface [polypeptide binding]; other site 169963005259 active site 169963005260 metal binding site [ion binding]; metal-binding site 169963005261 Predicted small secreted protein [Function unknown]; Region: COG5584 169963005262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 169963005263 putative homodimer interface [polypeptide binding]; other site 169963005264 putative homotetramer interface [polypeptide binding]; other site 169963005265 putative allosteric switch controlling residues; other site 169963005266 putative metal binding site [ion binding]; other site 169963005267 putative homodimer-homodimer interface [polypeptide binding]; other site 169963005268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 169963005269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005270 S-adenosylmethionine binding site [chemical binding]; other site 169963005271 Phosphotransferase enzyme family; Region: APH; pfam01636 169963005272 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 169963005273 active site 169963005274 substrate binding site [chemical binding]; other site 169963005275 ATP binding site [chemical binding]; other site 169963005276 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 169963005277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963005278 putative substrate translocation pore; other site 169963005279 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 169963005280 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963005281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963005282 putative DNA binding site [nucleotide binding]; other site 169963005283 putative Zn2+ binding site [ion binding]; other site 169963005284 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 169963005285 homodimer interface [polypeptide binding]; other site 169963005286 substrate-cofactor binding pocket; other site 169963005287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005288 catalytic residue [active] 169963005289 dipeptidase PepV; Reviewed; Region: PRK07318 169963005290 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 169963005291 active site 169963005292 metal binding site [ion binding]; metal-binding site 169963005293 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 169963005294 nudix motif; other site 169963005295 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 169963005296 putative substrate binding site [chemical binding]; other site 169963005297 putative ATP binding site [chemical binding]; other site 169963005298 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 169963005299 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 169963005300 active site 169963005301 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 169963005302 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 169963005303 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 169963005304 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 169963005305 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 169963005306 substrate binding site [chemical binding]; other site 169963005307 active site 169963005308 catalytic residues [active] 169963005309 heterodimer interface [polypeptide binding]; other site 169963005310 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 169963005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005312 catalytic residue [active] 169963005313 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 169963005314 active site 169963005315 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 169963005316 active site 169963005317 ribulose/triose binding site [chemical binding]; other site 169963005318 phosphate binding site [ion binding]; other site 169963005319 substrate (anthranilate) binding pocket [chemical binding]; other site 169963005320 product (indole) binding pocket [chemical binding]; other site 169963005321 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 169963005322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 169963005323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 169963005324 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 169963005325 Glutamine amidotransferase class-I; Region: GATase; pfam00117 169963005326 glutamine binding [chemical binding]; other site 169963005327 catalytic triad [active] 169963005328 anthranilate synthase component I; Provisional; Region: PRK13570 169963005329 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 169963005330 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 169963005331 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 169963005332 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 169963005333 putative catalytic cysteine [active] 169963005334 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 169963005335 putative active site [active] 169963005336 metal binding site [ion binding]; metal-binding site 169963005337 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 169963005338 dimer interface [polypeptide binding]; other site 169963005339 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963005340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963005341 Walker A/P-loop; other site 169963005342 ATP binding site [chemical binding]; other site 169963005343 Q-loop/lid; other site 169963005344 ABC transporter signature motif; other site 169963005345 Walker B; other site 169963005346 D-loop; other site 169963005347 H-loop/switch region; other site 169963005348 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 169963005349 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 169963005350 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 169963005351 putative dimer interface [polypeptide binding]; other site 169963005352 catalytic triad [active] 169963005353 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 169963005354 aconitate hydratase; Validated; Region: PRK09277 169963005355 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 169963005356 substrate binding site [chemical binding]; other site 169963005357 ligand binding site [chemical binding]; other site 169963005358 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 169963005359 substrate binding site [chemical binding]; other site 169963005360 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963005361 Heat induced stress protein YflT; Region: YflT; pfam11181 169963005362 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 169963005363 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 169963005364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963005365 ATP binding site [chemical binding]; other site 169963005366 putative Mg++ binding site [ion binding]; other site 169963005367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963005368 nucleotide binding region [chemical binding]; other site 169963005369 ATP-binding site [chemical binding]; other site 169963005370 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 169963005371 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 169963005372 Walker A/P-loop; other site 169963005373 ATP binding site [chemical binding]; other site 169963005374 Q-loop/lid; other site 169963005375 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 169963005376 ABC transporter signature motif; other site 169963005377 Walker B; other site 169963005378 D-loop; other site 169963005379 H-loop/switch region; other site 169963005380 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 169963005381 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 169963005382 active site 169963005383 metal binding site [ion binding]; metal-binding site 169963005384 DNA binding site [nucleotide binding] 169963005385 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 169963005386 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 169963005387 putative acyl-acceptor binding pocket; other site 169963005388 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 169963005389 MAEBL; Provisional; Region: PTZ00121 169963005390 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 169963005391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963005392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963005393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963005394 Walker A/P-loop; other site 169963005395 ATP binding site [chemical binding]; other site 169963005396 Q-loop/lid; other site 169963005397 ABC transporter signature motif; other site 169963005398 Walker B; other site 169963005399 D-loop; other site 169963005400 H-loop/switch region; other site 169963005401 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963005402 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 169963005403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963005404 Walker A/P-loop; other site 169963005405 ATP binding site [chemical binding]; other site 169963005406 Q-loop/lid; other site 169963005407 ABC transporter signature motif; other site 169963005408 Walker B; other site 169963005409 D-loop; other site 169963005410 H-loop/switch region; other site 169963005411 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 169963005412 active site 169963005413 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 169963005414 elongation factor Ts; Provisional; Region: tsf; PRK09377 169963005415 UBA/TS-N domain; Region: UBA; pfam00627 169963005416 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 169963005417 rRNA interaction site [nucleotide binding]; other site 169963005418 S8 interaction site; other site 169963005419 putative laminin-1 binding site; other site 169963005420 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 169963005421 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 169963005422 active site 169963005423 HIGH motif; other site 169963005424 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 169963005425 KMSKS motif; other site 169963005426 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 169963005427 tRNA binding surface [nucleotide binding]; other site 169963005428 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 169963005429 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 169963005430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005431 S-adenosylmethionine binding site [chemical binding]; other site 169963005432 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 169963005433 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 169963005434 active site 169963005435 dimer interface [polypeptide binding]; other site 169963005436 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 169963005437 Ligand Binding Site [chemical binding]; other site 169963005438 Molecular Tunnel; other site 169963005439 S-adenosylmethionine synthetase; Validated; Region: PRK05250 169963005440 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 169963005441 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 169963005442 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 169963005443 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963005444 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963005445 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 169963005446 HYR domain; Region: HYR; pfam02494 169963005447 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 169963005448 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963005449 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 169963005450 NAD binding site [chemical binding]; other site 169963005451 dimer interface [polypeptide binding]; other site 169963005452 substrate binding site [chemical binding]; other site 169963005453 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 169963005454 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 169963005455 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 169963005456 nudix motif; other site 169963005457 Uncharacterized conserved protein [Function unknown]; Region: COG0759 169963005458 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 169963005459 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 169963005460 metal binding site [ion binding]; metal-binding site 169963005461 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 169963005462 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 169963005463 acyl-activating enzyme (AAE) consensus motif; other site 169963005464 putative AMP binding site [chemical binding]; other site 169963005465 putative active site [active] 169963005466 putative CoA binding site [chemical binding]; other site 169963005467 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 169963005468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 169963005469 substrate binding site [chemical binding]; other site 169963005470 oxyanion hole (OAH) forming residues; other site 169963005471 trimer interface [polypeptide binding]; other site 169963005472 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 169963005473 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963005474 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 169963005475 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 169963005476 dimer interface [polypeptide binding]; other site 169963005477 tetramer interface [polypeptide binding]; other site 169963005478 PYR/PP interface [polypeptide binding]; other site 169963005479 TPP binding site [chemical binding]; other site 169963005480 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 169963005481 TPP-binding site; other site 169963005482 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 169963005483 chorismate binding enzyme; Region: Chorismate_bind; cl10555 169963005484 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 169963005485 putative active site [active] 169963005486 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 169963005487 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 169963005488 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 169963005489 FAD binding site [chemical binding]; other site 169963005490 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 169963005491 homodimer interface [polypeptide binding]; other site 169963005492 substrate-cofactor binding pocket; other site 169963005493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005494 catalytic residue [active] 169963005495 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 169963005496 homodimer interface [polypeptide binding]; other site 169963005497 substrate-cofactor binding pocket; other site 169963005498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005499 catalytic residue [active] 169963005500 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 169963005501 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 169963005502 THF binding site; other site 169963005503 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 169963005504 substrate binding site [chemical binding]; other site 169963005505 THF binding site; other site 169963005506 zinc-binding site [ion binding]; other site 169963005507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963005508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963005509 putative substrate translocation pore; other site 169963005510 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 169963005511 metal binding site 2 [ion binding]; metal-binding site 169963005512 putative DNA binding helix; other site 169963005513 metal binding site 1 [ion binding]; metal-binding site 169963005514 dimer interface [polypeptide binding]; other site 169963005515 structural Zn2+ binding site [ion binding]; other site 169963005516 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 169963005517 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 169963005518 NAD binding site [chemical binding]; other site 169963005519 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 169963005520 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 169963005521 inhibitor-cofactor binding pocket; inhibition site 169963005522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963005523 catalytic residue [active] 169963005524 Predicted membrane protein [Function unknown]; Region: COG4129 169963005525 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 169963005526 hypothetical protein; Provisional; Region: PRK13662 169963005527 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 169963005528 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 169963005529 putative NAD(P) binding site [chemical binding]; other site 169963005530 active site 169963005531 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 169963005532 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 169963005533 minor groove reading motif; other site 169963005534 helix-hairpin-helix signature motif; other site 169963005535 substrate binding pocket [chemical binding]; other site 169963005536 active site 169963005537 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 169963005538 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 169963005539 DNA binding and oxoG recognition site [nucleotide binding] 169963005540 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 169963005541 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 169963005542 trimer interface [polypeptide binding]; other site 169963005543 active site 169963005544 WVELL protein; Region: WVELL; pfam14043 169963005545 recombination regulator RecX; Provisional; Region: recX; PRK14135 169963005546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 169963005547 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 169963005548 NAD(P) binding site [chemical binding]; other site 169963005549 active site 169963005550 Predicted integral membrane protein [Function unknown]; Region: COG0392 169963005551 Uncharacterized conserved protein [Function unknown]; Region: COG2898 169963005552 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 169963005553 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 169963005554 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 169963005555 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 169963005556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963005557 PAS fold; Region: PAS_4; pfam08448 169963005558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 169963005559 putative active site [active] 169963005560 heme pocket [chemical binding]; other site 169963005561 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 169963005562 dimer interface [polypeptide binding]; other site 169963005563 putative CheW interface [polypeptide binding]; other site 169963005564 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 169963005565 active site 169963005566 metal binding site [ion binding]; metal-binding site 169963005567 TRAM domain; Region: TRAM; cl01282 169963005568 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 169963005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005570 S-adenosylmethionine binding site [chemical binding]; other site 169963005571 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 169963005572 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 169963005573 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 169963005574 Substrate-binding site [chemical binding]; other site 169963005575 Substrate specificity [chemical binding]; other site 169963005576 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 169963005577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 169963005578 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 169963005579 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 169963005580 active site 169963005581 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 169963005582 flavodoxin, short chain; Region: flav_short; TIGR01753 169963005583 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 169963005584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963005585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963005586 putative substrate translocation pore; other site 169963005587 rod shape-determining protein MreB; Provisional; Region: PRK13930 169963005588 MreB and similar proteins; Region: MreB_like; cd10225 169963005589 nucleotide binding site [chemical binding]; other site 169963005590 Mg binding site [ion binding]; other site 169963005591 putative protofilament interaction site [polypeptide binding]; other site 169963005592 RodZ interaction site [polypeptide binding]; other site 169963005593 Methyltransferase domain; Region: Methyltransf_31; pfam13847 169963005594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005595 S-adenosylmethionine binding site [chemical binding]; other site 169963005596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963005597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963005598 Uncharacterized conserved protein [Function unknown]; Region: COG4748 169963005599 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 169963005600 Uncharacterized conserved protein [Function unknown]; Region: COG3589 169963005601 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963005602 methionine cluster; other site 169963005603 active site 169963005604 phosphorylation site [posttranslational modification] 169963005605 metal binding site [ion binding]; metal-binding site 169963005606 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963005607 active site 169963005608 P-loop; other site 169963005609 phosphorylation site [posttranslational modification] 169963005610 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 169963005611 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 169963005612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963005613 Walker A motif; other site 169963005614 ATP binding site [chemical binding]; other site 169963005615 Walker B motif; other site 169963005616 arginine finger; other site 169963005617 Transcriptional antiterminator [Transcription]; Region: COG3933 169963005618 PRD domain; Region: PRD; pfam00874 169963005619 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963005620 active pocket/dimerization site; other site 169963005621 active site 169963005622 phosphorylation site [posttranslational modification] 169963005623 PRD domain; Region: PRD; pfam00874 169963005624 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 169963005625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 169963005626 ATP binding site [chemical binding]; other site 169963005627 putative Mg++ binding site [ion binding]; other site 169963005628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963005629 nucleotide binding region [chemical binding]; other site 169963005630 ATP-binding site [chemical binding]; other site 169963005631 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 169963005632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963005633 Walker A/P-loop; other site 169963005634 ATP binding site [chemical binding]; other site 169963005635 Q-loop/lid; other site 169963005636 ABC transporter signature motif; other site 169963005637 Walker B; other site 169963005638 D-loop; other site 169963005639 H-loop/switch region; other site 169963005640 Predicted transcriptional regulators [Transcription]; Region: COG1725 169963005641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963005642 DNA-binding site [nucleotide binding]; DNA binding site 169963005643 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963005644 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963005645 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963005646 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963005647 DNA binding site [nucleotide binding] 169963005648 domain linker motif; other site 169963005649 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963005650 dimerization interface [polypeptide binding]; other site 169963005651 ligand binding site [chemical binding]; other site 169963005652 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 169963005653 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 169963005654 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 169963005655 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 169963005656 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 169963005657 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963005658 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 169963005659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963005660 dimer interface [polypeptide binding]; other site 169963005661 conserved gate region; other site 169963005662 putative PBP binding loops; other site 169963005663 ABC-ATPase subunit interface; other site 169963005664 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963005665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963005666 dimer interface [polypeptide binding]; other site 169963005667 conserved gate region; other site 169963005668 putative PBP binding loops; other site 169963005669 ABC-ATPase subunit interface; other site 169963005670 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 169963005671 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 169963005672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963005673 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 169963005674 NAD(P) binding pocket [chemical binding]; other site 169963005675 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 169963005676 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 169963005677 active site 169963005678 dimer interface [polypeptide binding]; other site 169963005679 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 169963005680 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 169963005681 active site 169963005682 FMN binding site [chemical binding]; other site 169963005683 substrate binding site [chemical binding]; other site 169963005684 3Fe-4S cluster binding site [ion binding]; other site 169963005685 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 169963005686 domain interface; other site 169963005687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963005688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963005689 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 169963005690 putative dimerization interface [polypeptide binding]; other site 169963005691 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963005692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963005693 Coenzyme A binding pocket [chemical binding]; other site 169963005694 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 169963005695 putative active site [active] 169963005696 metal binding site [ion binding]; metal-binding site 169963005697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 169963005698 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 169963005699 substrate binding pocket [chemical binding]; other site 169963005700 membrane-bound complex binding site; other site 169963005701 hinge residues; other site 169963005702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963005703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963005704 Walker A/P-loop; other site 169963005705 ATP binding site [chemical binding]; other site 169963005706 Q-loop/lid; other site 169963005707 ABC transporter signature motif; other site 169963005708 Walker B; other site 169963005709 D-loop; other site 169963005710 H-loop/switch region; other site 169963005711 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963005712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963005713 dimer interface [polypeptide binding]; other site 169963005714 conserved gate region; other site 169963005715 putative PBP binding loops; other site 169963005716 ABC-ATPase subunit interface; other site 169963005717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 169963005718 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963005719 dimer interface [polypeptide binding]; other site 169963005720 phosphorylation site [posttranslational modification] 169963005721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963005722 ATP binding site [chemical binding]; other site 169963005723 Mg2+ binding site [ion binding]; other site 169963005724 G-X-G motif; other site 169963005725 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 169963005726 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 169963005727 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 169963005728 active site 169963005729 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 169963005730 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 169963005731 putative NAD(P) binding site [chemical binding]; other site 169963005732 active site 169963005733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963005734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963005735 active site 169963005736 phosphorylation site [posttranslational modification] 169963005737 intermolecular recognition site; other site 169963005738 dimerization interface [polypeptide binding]; other site 169963005739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963005740 DNA binding site [nucleotide binding] 169963005741 FtsX-like permease family; Region: FtsX; pfam02687 169963005742 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963005743 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963005744 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963005745 Walker A/P-loop; other site 169963005746 ATP binding site [chemical binding]; other site 169963005747 Q-loop/lid; other site 169963005748 ABC transporter signature motif; other site 169963005749 Walker B; other site 169963005750 D-loop; other site 169963005751 H-loop/switch region; other site 169963005752 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 169963005753 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 169963005754 ADP binding site [chemical binding]; other site 169963005755 magnesium binding site [ion binding]; other site 169963005756 putative shikimate binding site; other site 169963005757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 169963005758 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 169963005759 TRAM domain; Region: TRAM; pfam01938 169963005760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 169963005761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963005762 S-adenosylmethionine binding site [chemical binding]; other site 169963005763 putative lipid kinase; Reviewed; Region: PRK13337 169963005764 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 169963005765 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 169963005766 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 169963005767 GatB domain; Region: GatB_Yqey; pfam02637 169963005768 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 169963005769 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 169963005770 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 169963005771 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 169963005772 putative dimer interface [polypeptide binding]; other site 169963005773 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 169963005774 putative dimer interface [polypeptide binding]; other site 169963005775 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 169963005776 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 169963005777 nucleotide binding pocket [chemical binding]; other site 169963005778 K-X-D-G motif; other site 169963005779 catalytic site [active] 169963005780 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 169963005781 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 169963005782 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 169963005783 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 169963005784 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 169963005785 Dimer interface [polypeptide binding]; other site 169963005786 BRCT sequence motif; other site 169963005787 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 169963005788 Part of AAA domain; Region: AAA_19; pfam13245 169963005789 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 169963005790 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 169963005791 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 169963005792 substrate binding site [chemical binding]; other site 169963005793 putative active site [active] 169963005794 dimer interface [polypeptide binding]; other site 169963005795 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 169963005796 Na2 binding site [ion binding]; other site 169963005797 putative substrate binding site 1 [chemical binding]; other site 169963005798 Na binding site 1 [ion binding]; other site 169963005799 putative substrate binding site 2 [chemical binding]; other site 169963005800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 169963005801 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 169963005802 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 169963005803 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 169963005804 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 169963005805 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 169963005806 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 169963005807 purine monophosphate binding site [chemical binding]; other site 169963005808 dimer interface [polypeptide binding]; other site 169963005809 putative catalytic residues [active] 169963005810 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 169963005811 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 169963005812 active site 169963005813 substrate binding site [chemical binding]; other site 169963005814 cosubstrate binding site; other site 169963005815 catalytic site [active] 169963005816 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 169963005817 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 169963005818 dimerization interface [polypeptide binding]; other site 169963005819 putative ATP binding site [chemical binding]; other site 169963005820 amidophosphoribosyltransferase; Provisional; Region: PRK06781 169963005821 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 169963005822 active site 169963005823 tetramer interface [polypeptide binding]; other site 169963005824 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963005825 active site 169963005826 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 169963005827 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 169963005828 dimerization interface [polypeptide binding]; other site 169963005829 ATP binding site [chemical binding]; other site 169963005830 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 169963005831 dimerization interface [polypeptide binding]; other site 169963005832 ATP binding site [chemical binding]; other site 169963005833 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 169963005834 putative active site [active] 169963005835 catalytic triad [active] 169963005836 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 169963005837 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 169963005838 ATP binding site [chemical binding]; other site 169963005839 active site 169963005840 substrate binding site [chemical binding]; other site 169963005841 adenylosuccinate lyase; Provisional; Region: PRK07492 169963005842 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 169963005843 tetramer interface [polypeptide binding]; other site 169963005844 active site 169963005845 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 169963005846 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 169963005847 ATP-grasp domain; Region: ATP-grasp; pfam02222 169963005848 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 169963005849 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 169963005850 hypothetical protein; Provisional; Region: PRK04164 169963005851 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 169963005852 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963005853 Zn2+ binding site [ion binding]; other site 169963005854 Mg2+ binding site [ion binding]; other site 169963005855 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 169963005856 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 169963005857 Walker A/P-loop; other site 169963005858 ATP binding site [chemical binding]; other site 169963005859 Q-loop/lid; other site 169963005860 ABC transporter signature motif; other site 169963005861 Walker B; other site 169963005862 D-loop; other site 169963005863 H-loop/switch region; other site 169963005864 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 169963005865 peptidase T-like protein; Region: PepT-like; TIGR01883 169963005866 metal binding site [ion binding]; metal-binding site 169963005867 dimer interface [polypeptide binding]; other site 169963005868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 169963005869 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 169963005870 active site 169963005871 putative catalytic site [active] 169963005872 DNA binding site [nucleotide binding] 169963005873 putative phosphate binding site [ion binding]; other site 169963005874 metal binding site A [ion binding]; metal-binding site 169963005875 AP binding site [nucleotide binding]; other site 169963005876 metal binding site B [ion binding]; metal-binding site 169963005877 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 169963005878 23S rRNA binding site [nucleotide binding]; other site 169963005879 L21 binding site [polypeptide binding]; other site 169963005880 L13 binding site [polypeptide binding]; other site 169963005881 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 169963005882 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 169963005883 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 169963005884 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 169963005885 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963005886 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963005887 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963005888 Substrate binding site [chemical binding]; other site 169963005889 Leucine rich repeat; Region: LRR_8; pfam13855 169963005890 LRR adjacent; Region: LRR_adjacent; pfam08191 169963005891 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 169963005892 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963005893 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 169963005894 DNA binding residues [nucleotide binding] 169963005895 dimer interface [polypeptide binding]; other site 169963005896 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 169963005897 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 169963005898 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 169963005899 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 169963005900 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 169963005901 RimM N-terminal domain; Region: RimM; pfam01782 169963005902 PRC-barrel domain; Region: PRC; pfam05239 169963005903 YlqD protein; Region: YlqD; pfam11068 169963005904 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 169963005905 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 169963005906 catalytic triad [active] 169963005907 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 169963005908 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 169963005909 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 169963005910 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 169963005911 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 169963005912 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 169963005913 signal recognition particle protein; Provisional; Region: PRK10867 169963005914 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 169963005915 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 169963005916 P loop; other site 169963005917 GTP binding site [chemical binding]; other site 169963005918 Signal peptide binding domain; Region: SRP_SPB; pfam02978 169963005919 putative DNA-binding protein; Validated; Region: PRK00118 169963005920 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 169963005921 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 169963005922 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 169963005923 P loop; other site 169963005924 GTP binding site [chemical binding]; other site 169963005925 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 169963005926 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 169963005927 Walker A/P-loop; other site 169963005928 ATP binding site [chemical binding]; other site 169963005929 Q-loop/lid; other site 169963005930 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 169963005931 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 169963005932 linker region; other site 169963005933 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 169963005934 ABC transporter signature motif; other site 169963005935 Walker B; other site 169963005936 D-loop; other site 169963005937 H-loop/switch region; other site 169963005938 ribonuclease III; Reviewed; Region: rnc; PRK00102 169963005939 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 169963005940 dimerization interface [polypeptide binding]; other site 169963005941 active site 169963005942 metal binding site [ion binding]; metal-binding site 169963005943 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 169963005944 dsRNA binding site [nucleotide binding]; other site 169963005945 acyl carrier protein; Provisional; Region: acpP; PRK00982 169963005946 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 169963005947 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 169963005948 NAD(P) binding site [chemical binding]; other site 169963005949 homotetramer interface [polypeptide binding]; other site 169963005950 homodimer interface [polypeptide binding]; other site 169963005951 active site 169963005952 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 169963005953 putative phosphate acyltransferase; Provisional; Region: PRK05331 169963005954 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 169963005955 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 169963005956 active site 2 [active] 169963005957 active site 1 [active] 169963005958 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 169963005959 Y-family of DNA polymerases; Region: PolY; cl12025 169963005960 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 169963005961 generic binding surface II; other site 169963005962 ssDNA binding site; other site 169963005963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963005964 ATP binding site [chemical binding]; other site 169963005965 putative Mg++ binding site [ion binding]; other site 169963005966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963005967 nucleotide binding region [chemical binding]; other site 169963005968 ATP-binding site [chemical binding]; other site 169963005969 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 169963005970 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 169963005971 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 169963005972 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 169963005973 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 169963005974 putative L-serine binding site [chemical binding]; other site 169963005975 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 169963005976 DAK2 domain; Region: Dak2; pfam02734 169963005977 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 169963005978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 169963005979 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 169963005980 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 169963005981 Thiamine pyrophosphokinase; Region: TPK; cd07995 169963005982 active site 169963005983 dimerization interface [polypeptide binding]; other site 169963005984 thiamine binding site [chemical binding]; other site 169963005985 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963005986 substrate binding site [chemical binding]; other site 169963005987 hexamer interface [polypeptide binding]; other site 169963005988 metal binding site [ion binding]; metal-binding site 169963005989 GTPase RsgA; Reviewed; Region: PRK00098 169963005990 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 169963005991 RNA binding site [nucleotide binding]; other site 169963005992 homodimer interface [polypeptide binding]; other site 169963005993 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 169963005994 GTPase/Zn-binding domain interface [polypeptide binding]; other site 169963005995 GTP/Mg2+ binding site [chemical binding]; other site 169963005996 G4 box; other site 169963005997 G1 box; other site 169963005998 Switch I region; other site 169963005999 G2 box; other site 169963006000 G3 box; other site 169963006001 Switch II region; other site 169963006002 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 169963006003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 169963006004 active site 169963006005 ATP binding site [chemical binding]; other site 169963006006 substrate binding site [chemical binding]; other site 169963006007 activation loop (A-loop); other site 169963006008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 169963006009 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 169963006010 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 169963006011 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 169963006012 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 169963006013 active site 169963006014 16S rRNA methyltransferase B; Provisional; Region: PRK14902 169963006015 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 169963006016 putative RNA binding site [nucleotide binding]; other site 169963006017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963006018 S-adenosylmethionine binding site [chemical binding]; other site 169963006019 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 169963006020 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 169963006021 putative active site [active] 169963006022 substrate binding site [chemical binding]; other site 169963006023 putative cosubstrate binding site; other site 169963006024 catalytic site [active] 169963006025 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 169963006026 substrate binding site [chemical binding]; other site 169963006027 primosome assembly protein PriA; Validated; Region: PRK05580 169963006028 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963006029 ATP binding site [chemical binding]; other site 169963006030 putative Mg++ binding site [ion binding]; other site 169963006031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963006032 ATP-binding site [chemical binding]; other site 169963006033 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 169963006034 Flavoprotein; Region: Flavoprotein; cl19190 169963006035 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 169963006036 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 169963006037 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 169963006038 catalytic site [active] 169963006039 G-X2-G-X-G-K; other site 169963006040 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 169963006041 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 169963006042 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 169963006043 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 169963006044 Domain of unknown function (DUF814); Region: DUF814; pfam05670 169963006045 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 169963006046 short chain dehydrogenase; Region: adh_short; pfam00106 169963006047 putative NAD(P) binding site [chemical binding]; other site 169963006048 homodimer interface [polypeptide binding]; other site 169963006049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963006050 active site 169963006051 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 169963006052 active site 169963006053 dimer interface [polypeptide binding]; other site 169963006054 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 169963006055 heterodimer interface [polypeptide binding]; other site 169963006056 active site 169963006057 FMN binding site [chemical binding]; other site 169963006058 homodimer interface [polypeptide binding]; other site 169963006059 substrate binding site [chemical binding]; other site 169963006060 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 169963006061 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 169963006062 FAD binding pocket [chemical binding]; other site 169963006063 FAD binding motif [chemical binding]; other site 169963006064 phosphate binding motif [ion binding]; other site 169963006065 beta-alpha-beta structure motif; other site 169963006066 NAD binding pocket [chemical binding]; other site 169963006067 Iron coordination center [ion binding]; other site 169963006068 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 169963006069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 169963006070 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 169963006071 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 169963006072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 169963006073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 169963006074 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 169963006075 IMP binding site; other site 169963006076 dimer interface [polypeptide binding]; other site 169963006077 interdomain contacts; other site 169963006078 partial ornithine binding site; other site 169963006079 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 169963006080 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 169963006081 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 169963006082 catalytic site [active] 169963006083 subunit interface [polypeptide binding]; other site 169963006084 dihydroorotase; Validated; Region: pyrC; PRK09357 169963006085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 169963006086 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 169963006087 active site 169963006088 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 169963006089 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 169963006090 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 169963006091 Sulfate transporter family; Region: Sulfate_transp; cl19250 169963006092 uracil-xanthine permease; Region: ncs2; TIGR00801 169963006093 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963006094 active site 169963006095 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 169963006096 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 169963006097 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963006098 RNA binding surface [nucleotide binding]; other site 169963006099 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 169963006100 active site 169963006101 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 169963006102 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 169963006103 Sulfate transporter family; Region: Sulfate_transp; cl19250 169963006104 multidrug efflux protein; Reviewed; Region: PRK01766 169963006105 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 169963006106 cation binding site [ion binding]; other site 169963006107 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 169963006108 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 169963006109 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 169963006110 metal binding site [ion binding]; metal-binding site 169963006111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963006112 ABC-ATPase subunit interface; other site 169963006113 dimer interface [polypeptide binding]; other site 169963006114 putative PBP binding regions; other site 169963006115 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 169963006116 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 169963006117 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 169963006118 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963006119 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 169963006120 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 169963006121 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 169963006122 protein binding site [polypeptide binding]; other site 169963006123 Catalytic dyad [active] 169963006124 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 169963006125 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 169963006126 metal-binding site [ion binding] 169963006127 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 169963006128 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 169963006129 metal-binding site [ion binding] 169963006130 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963006131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963006132 motif II; other site 169963006133 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 169963006134 putative homodimer interface [polypeptide binding]; other site 169963006135 putative homotetramer interface [polypeptide binding]; other site 169963006136 putative allosteric switch controlling residues; other site 169963006137 putative metal binding site [ion binding]; other site 169963006138 putative homodimer-homodimer interface [polypeptide binding]; other site 169963006139 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 169963006140 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 169963006141 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 169963006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4479 169963006143 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963006144 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963006145 methionine sulfoxide reductase B; Provisional; Region: PRK00222 169963006146 methionine sulfoxide reductase A; Provisional; Region: PRK14054 169963006147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 169963006148 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 169963006149 active site 169963006150 catalytic triad [active] 169963006151 oxyanion hole [active] 169963006152 EDD domain protein, DegV family; Region: DegV; TIGR00762 169963006153 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 169963006154 HTH domain; Region: HTH_11; pfam08279 169963006155 FOG: CBS domain [General function prediction only]; Region: COG0517 169963006156 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 169963006157 PEP synthetase regulatory protein; Provisional; Region: PRK05339 169963006158 pyruvate phosphate dikinase; Provisional; Region: PRK09279 169963006159 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 169963006160 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 169963006161 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 169963006162 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 169963006163 Predicted membrane protein [Function unknown]; Region: COG4129 169963006164 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 169963006165 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 169963006166 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 169963006167 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 169963006168 active site 169963006169 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 169963006170 substrate binding site [chemical binding]; other site 169963006171 metal binding site [ion binding]; metal-binding site 169963006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 169963006173 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 169963006174 folate binding site [chemical binding]; other site 169963006175 NADP+ binding site [chemical binding]; other site 169963006176 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 169963006177 dimerization interface [polypeptide binding]; other site 169963006178 active site 169963006179 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 169963006180 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963006181 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 169963006182 ABC transporter; Region: ABC_tran_2; pfam12848 169963006183 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963006184 formyl-tetrahydrofolate synthetase C-terminal 169963006185 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 169963006186 manganese transport transcriptional regulator; Provisional; Region: PRK03902 169963006187 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 169963006188 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 169963006189 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 169963006190 DNA-binding site [nucleotide binding]; DNA binding site 169963006191 RNA-binding motif; other site 169963006192 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 169963006193 RNA/DNA hybrid binding site [nucleotide binding]; other site 169963006194 active site 169963006195 5'-3' exonuclease; Region: 53EXOc; smart00475 169963006196 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 169963006197 active site 169963006198 metal binding site 1 [ion binding]; metal-binding site 169963006199 putative 5' ssDNA interaction site; other site 169963006200 metal binding site 3; metal-binding site 169963006201 metal binding site 2 [ion binding]; metal-binding site 169963006202 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 169963006203 putative DNA binding site [nucleotide binding]; other site 169963006204 putative metal binding site [ion binding]; other site 169963006205 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 169963006206 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 169963006207 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 169963006208 putative active site [active] 169963006209 Sulfate transporter family; Region: Sulfate_transp; cl19250 169963006210 xanthine permease; Region: pbuX; TIGR03173 169963006211 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963006212 active site 169963006213 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 169963006214 active site 169963006215 Zn binding site [ion binding]; other site 169963006216 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 169963006217 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 169963006218 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 169963006219 cell division protein GpsB; Provisional; Region: PRK14127 169963006220 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 169963006221 hypothetical protein; Provisional; Region: PRK13660 169963006222 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 169963006223 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 169963006224 Transglycosylase; Region: Transgly; pfam00912 169963006225 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 169963006226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 169963006227 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 169963006228 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 169963006229 minor groove reading motif; other site 169963006230 helix-hairpin-helix signature motif; other site 169963006231 substrate binding pocket [chemical binding]; other site 169963006232 active site 169963006233 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 169963006234 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 169963006235 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 169963006236 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 169963006237 putative dimer interface [polypeptide binding]; other site 169963006238 putative anticodon binding site; other site 169963006239 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 169963006240 homodimer interface [polypeptide binding]; other site 169963006241 motif 1; other site 169963006242 motif 2; other site 169963006243 active site 169963006244 motif 3; other site 169963006245 aspartate aminotransferase; Provisional; Region: PRK05764 169963006246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963006247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963006248 homodimer interface [polypeptide binding]; other site 169963006249 catalytic residue [active] 169963006250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 169963006251 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 169963006252 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 169963006253 active site 169963006254 catalytic site [active] 169963006255 substrate binding site [chemical binding]; other site 169963006256 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 169963006257 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 169963006258 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 169963006259 tetramerization interface [polypeptide binding]; other site 169963006260 active site 169963006261 Pantoate-beta-alanine ligase; Region: PanC; cd00560 169963006262 active site 169963006263 ATP-binding site [chemical binding]; other site 169963006264 pantoate-binding site; other site 169963006265 HXXH motif; other site 169963006266 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 169963006267 active site 169963006268 oligomerization interface [polypeptide binding]; other site 169963006269 metal binding site [ion binding]; metal-binding site 169963006270 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963006271 catalytic residues [active] 169963006272 Biotin operon repressor [Transcription]; Region: BirA; COG1654 169963006273 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 169963006274 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 169963006275 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 169963006276 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 169963006277 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 169963006278 active site 169963006279 NTP binding site [chemical binding]; other site 169963006280 metal binding triad [ion binding]; metal-binding site 169963006281 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 169963006282 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 169963006283 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 169963006284 active site 169963006285 dimer interfaces [polypeptide binding]; other site 169963006286 catalytic residues [active] 169963006287 dihydrodipicolinate reductase; Provisional; Region: PRK00048 169963006288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 169963006289 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 169963006290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 169963006291 homodimer interface [polypeptide binding]; other site 169963006292 metal binding site [ion binding]; metal-binding site 169963006293 Uncharacterized conserved protein [Function unknown]; Region: COG1284 169963006294 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963006295 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963006296 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 169963006297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 169963006298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963006299 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 169963006300 metal binding site [ion binding]; metal-binding site 169963006301 active site 169963006302 I-site; other site 169963006303 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 169963006304 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 169963006305 metal binding site [ion binding]; metal-binding site 169963006306 active site 169963006307 I-site; other site 169963006308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 169963006309 malate dehydrogenase; Provisional; Region: PRK13529 169963006310 Malic enzyme, N-terminal domain; Region: malic; pfam00390 169963006311 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 169963006312 NAD(P) binding site [chemical binding]; other site 169963006313 Beta-lactamase; Region: Beta-lactamase; pfam00144 169963006314 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 169963006315 Pyruvate formate lyase 1; Region: PFL1; cd01678 169963006316 coenzyme A binding site [chemical binding]; other site 169963006317 active site 169963006318 catalytic residues [active] 169963006319 glycine loop; other site 169963006320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963006321 HI0933-like protein; Region: HI0933_like; pfam03486 169963006322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963006323 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 169963006324 Predicted membrane protein [Function unknown]; Region: COG4347 169963006325 hypothetical protein; Provisional; Region: PRK03636 169963006326 UPF0302 domain; Region: UPF0302; pfam08864 169963006327 IDEAL domain; Region: IDEAL; pfam08858 169963006328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963006329 binding surface 169963006330 TPR motif; other site 169963006331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963006332 binding surface 169963006333 TPR motif; other site 169963006334 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 169963006335 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963006336 binding surface 169963006337 TPR motif; other site 169963006338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963006339 binding surface 169963006340 TPR motif; other site 169963006341 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 169963006342 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 169963006343 hinge; other site 169963006344 active site 169963006345 prephenate dehydrogenase; Validated; Region: PRK08507 169963006346 prephenate dehydrogenase; Validated; Region: PRK06545 169963006347 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 169963006348 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 169963006349 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963006350 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963006351 homodimer interface [polypeptide binding]; other site 169963006352 catalytic residue [active] 169963006353 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 169963006354 homotrimer interaction site [polypeptide binding]; other site 169963006355 active site 169963006356 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 169963006357 active site 169963006358 dimer interface [polypeptide binding]; other site 169963006359 metal binding site [ion binding]; metal-binding site 169963006360 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 169963006361 Tetramer interface [polypeptide binding]; other site 169963006362 active site 169963006363 FMN-binding site [chemical binding]; other site 169963006364 Nucleoside diphosphate kinase; Region: NDK; pfam00334 169963006365 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 169963006366 active site 169963006367 multimer interface [polypeptide binding]; other site 169963006368 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 169963006369 substrate binding pocket [chemical binding]; other site 169963006370 active site lid residues [active] 169963006371 substrate-Mg2+ binding site; other site 169963006372 catalytic residues [active] 169963006373 aspartate-rich region 1; other site 169963006374 aspartate-rich region 2; other site 169963006375 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 169963006376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963006377 S-adenosylmethionine binding site [chemical binding]; other site 169963006378 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 169963006379 GTP cyclohydrolase I; Region: GTP_cyclohydroI; pfam01227 169963006380 active site 169963006381 histone-like DNA-binding protein HU; Region: HU; cd13831 169963006382 dimer interface [polypeptide binding]; other site 169963006383 DNA binding site [nucleotide binding] 169963006384 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 169963006385 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 169963006386 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 169963006387 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 169963006388 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 169963006389 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 169963006390 GTP-binding protein Der; Reviewed; Region: PRK00093 169963006391 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 169963006392 G1 box; other site 169963006393 GTP/Mg2+ binding site [chemical binding]; other site 169963006394 Switch I region; other site 169963006395 G2 box; other site 169963006396 Switch II region; other site 169963006397 G3 box; other site 169963006398 G4 box; other site 169963006399 G5 box; other site 169963006400 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 169963006401 G1 box; other site 169963006402 GTP/Mg2+ binding site [chemical binding]; other site 169963006403 Switch I region; other site 169963006404 G2 box; other site 169963006405 G3 box; other site 169963006406 Switch II region; other site 169963006407 G4 box; other site 169963006408 G5 box; other site 169963006409 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 169963006410 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 169963006411 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 169963006412 RNA binding site [nucleotide binding]; other site 169963006413 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 169963006414 RNA binding site [nucleotide binding]; other site 169963006415 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 169963006416 RNA binding site [nucleotide binding]; other site 169963006417 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 169963006418 RNA binding site [nucleotide binding]; other site 169963006419 cytidylate kinase; Provisional; Region: cmk; PRK00023 169963006420 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 169963006421 CMP-binding site; other site 169963006422 The sites determining sugar specificity; other site 169963006423 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 169963006424 cytoplasmic asparaginase I; Provisional; Region: ansA; PRK09461 169963006425 active site 169963006426 homotetramer interface [polypeptide binding]; other site 169963006427 homodimer interface [polypeptide binding]; other site 169963006428 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 169963006429 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963006430 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 169963006431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963006432 ATP binding site [chemical binding]; other site 169963006433 putative Mg++ binding site [ion binding]; other site 169963006434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963006435 nucleotide binding region [chemical binding]; other site 169963006436 ATP-binding site [chemical binding]; other site 169963006437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 169963006438 Helix-turn-helix domain; Region: HTH_40; pfam14493 169963006439 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 169963006440 Predicted membrane protein [Function unknown]; Region: COG3601 169963006441 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 169963006442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 169963006443 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963006444 dimerization interface [polypeptide binding]; other site 169963006445 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963006446 dimer interface [polypeptide binding]; other site 169963006447 phosphorylation site [posttranslational modification] 169963006448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963006449 ATP binding site [chemical binding]; other site 169963006450 Mg2+ binding site [ion binding]; other site 169963006451 G-X-G motif; other site 169963006452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963006453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963006454 active site 169963006455 phosphorylation site [posttranslational modification] 169963006456 intermolecular recognition site; other site 169963006457 dimerization interface [polypeptide binding]; other site 169963006458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963006459 DNA binding site [nucleotide binding] 169963006460 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 169963006461 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963006462 RNA binding surface [nucleotide binding]; other site 169963006463 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 169963006464 active site 169963006465 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 169963006466 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 169963006467 diaminopimelate decarboxylase; Region: lysA; TIGR01048 169963006468 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 169963006469 active site 169963006470 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 169963006471 substrate binding site [chemical binding]; other site 169963006472 catalytic residues [active] 169963006473 dimer interface [polypeptide binding]; other site 169963006474 purine nucleoside phosphorylase; Provisional; Region: PRK08202 169963006475 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 169963006476 phosphopentomutase; Provisional; Region: PRK05362 169963006477 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 169963006478 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 169963006479 active site 169963006480 Int/Topo IB signature motif; other site 169963006481 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 169963006482 metal binding site 2 [ion binding]; metal-binding site 169963006483 putative DNA binding helix; other site 169963006484 metal binding site 1 [ion binding]; metal-binding site 169963006485 dimer interface [polypeptide binding]; other site 169963006486 structural Zn2+ binding site [ion binding]; other site 169963006487 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963006488 ABC-ATPase subunit interface; other site 169963006489 dimer interface [polypeptide binding]; other site 169963006490 putative PBP binding regions; other site 169963006491 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963006492 ABC-ATPase subunit interface; other site 169963006493 dimer interface [polypeptide binding]; other site 169963006494 putative PBP binding regions; other site 169963006495 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 169963006496 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 169963006497 putative ligand binding residues [chemical binding]; other site 169963006498 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 169963006499 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 169963006500 Walker A/P-loop; other site 169963006501 ATP binding site [chemical binding]; other site 169963006502 Q-loop/lid; other site 169963006503 ABC transporter signature motif; other site 169963006504 Walker B; other site 169963006505 D-loop; other site 169963006506 H-loop/switch region; other site 169963006507 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 169963006508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963006509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963006510 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963006511 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 169963006512 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963006513 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963006514 Walker A/P-loop; other site 169963006515 ATP binding site [chemical binding]; other site 169963006516 Q-loop/lid; other site 169963006517 ABC transporter signature motif; other site 169963006518 Walker B; other site 169963006519 D-loop; other site 169963006520 H-loop/switch region; other site 169963006521 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 169963006522 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 169963006523 dimer interface [polypeptide binding]; other site 169963006524 ADP-ribose binding site [chemical binding]; other site 169963006525 active site 169963006526 nudix motif; other site 169963006527 metal binding site [ion binding]; metal-binding site 169963006528 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 169963006529 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 169963006530 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 169963006531 Creatinine amidohydrolase; Region: Creatininase; pfam02633 169963006532 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 169963006533 active site 169963006534 intersubunit interface [polypeptide binding]; other site 169963006535 catalytic residue [active] 169963006536 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 169963006537 active site 169963006538 substrate binding pocket [chemical binding]; other site 169963006539 homodimer interaction site [polypeptide binding]; other site 169963006540 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 169963006541 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 169963006542 active site 169963006543 P-loop; other site 169963006544 phosphorylation site [posttranslational modification] 169963006545 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963006546 active site 169963006547 phosphorylation site [posttranslational modification] 169963006548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963006549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963006550 DNA-binding site [nucleotide binding]; DNA binding site 169963006551 UTRA domain; Region: UTRA; pfam07702 169963006552 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 169963006553 active site 169963006554 DNA polymerase IV; Validated; Region: PRK02406 169963006555 DNA binding site [nucleotide binding] 169963006556 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 169963006557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 169963006558 NAD(P) binding site [chemical binding]; other site 169963006559 active site 169963006560 ribonuclease Z; Region: RNase_Z; TIGR02651 169963006561 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 169963006562 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 169963006563 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 169963006564 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 169963006565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 169963006566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963006567 Coenzyme A binding pocket [chemical binding]; other site 169963006568 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 169963006569 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 169963006570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 169963006571 PYR/PP interface [polypeptide binding]; other site 169963006572 dimer interface [polypeptide binding]; other site 169963006573 TPP binding site [chemical binding]; other site 169963006574 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 169963006575 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 169963006576 TPP-binding site [chemical binding]; other site 169963006577 dimer interface [polypeptide binding]; other site 169963006578 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 169963006579 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 169963006580 putative valine binding site [chemical binding]; other site 169963006581 dimer interface [polypeptide binding]; other site 169963006582 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 169963006583 ketol-acid reductoisomerase; Provisional; Region: PRK05479 169963006584 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 169963006585 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 169963006586 2-isopropylmalate synthase; Validated; Region: PRK00915 169963006587 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 169963006588 active site 169963006589 catalytic residues [active] 169963006590 metal binding site [ion binding]; metal-binding site 169963006591 LeuA allosteric (dimerization) domain; Region: LeuA_dimer; pfam08502 169963006592 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 169963006593 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 169963006594 substrate binding site [chemical binding]; other site 169963006595 ligand binding site [chemical binding]; other site 169963006596 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 169963006597 substrate binding site [chemical binding]; other site 169963006598 threonine dehydratase; Validated; Region: PRK08639 169963006599 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 169963006600 tetramer interface [polypeptide binding]; other site 169963006601 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963006602 catalytic residue [active] 169963006603 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 169963006604 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 169963006605 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 169963006606 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 169963006607 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 169963006608 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 169963006609 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963006610 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963006611 DNA binding site [nucleotide binding] 169963006612 domain linker motif; other site 169963006613 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963006614 dimerization interface [polypeptide binding]; other site 169963006615 ligand binding site [chemical binding]; other site 169963006616 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 169963006617 intersubunit interface [polypeptide binding]; other site 169963006618 active site 169963006619 catalytic residue [active] 169963006620 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 169963006621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 169963006622 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 169963006623 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 169963006624 active pocket/dimerization site; other site 169963006625 active site 169963006626 phosphorylation site [posttranslational modification] 169963006627 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 169963006628 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 169963006629 putative active site [active] 169963006630 SIS domain; Region: SIS; pfam01380 169963006631 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 169963006632 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 169963006633 dimer interface [polypeptide binding]; other site 169963006634 active site 169963006635 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 169963006636 dimer interface [polypeptide binding]; other site 169963006637 active site 169963006638 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 169963006639 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 169963006640 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 169963006641 active site 169963006642 phosphorylation site [posttranslational modification] 169963006643 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963006644 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963006645 DNA-binding site [nucleotide binding]; DNA binding site 169963006646 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 169963006647 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963006648 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 169963006649 DNA-binding site [nucleotide binding]; DNA binding site 169963006650 UTRA domain; Region: UTRA; pfam07702 169963006651 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963006652 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 169963006653 active site 169963006654 catalytic tetrad [active] 169963006655 acetolactate synthase; Reviewed; Region: PRK08617 169963006656 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 169963006657 PYR/PP interface [polypeptide binding]; other site 169963006658 dimer interface [polypeptide binding]; other site 169963006659 TPP binding site [chemical binding]; other site 169963006660 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 169963006661 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 169963006662 TPP-binding site [chemical binding]; other site 169963006663 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963006664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 169963006665 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 169963006666 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963006667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963006668 dimer interface [polypeptide binding]; other site 169963006669 conserved gate region; other site 169963006670 ABC-ATPase subunit interface; other site 169963006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963006672 dimer interface [polypeptide binding]; other site 169963006673 conserved gate region; other site 169963006674 ABC-ATPase subunit interface; other site 169963006675 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 169963006676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963006677 active site 169963006678 phosphorylation site [posttranslational modification] 169963006679 intermolecular recognition site; other site 169963006680 dimerization interface [polypeptide binding]; other site 169963006681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963006682 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 169963006683 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963006684 dimerization interface [polypeptide binding]; other site 169963006685 Histidine kinase; Region: His_kinase; pfam06580 169963006686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963006687 ATP binding site [chemical binding]; other site 169963006688 Mg2+ binding site [ion binding]; other site 169963006689 G-X-G motif; other site 169963006690 Predicted integral membrane protein [Function unknown]; Region: COG5578 169963006691 Uncharacterized conserved protein [Function unknown]; Region: COG3538 169963006692 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 169963006693 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 169963006694 active site 169963006695 metal binding site [ion binding]; metal-binding site 169963006696 homodimer interface [polypeptide binding]; other site 169963006697 catalytic site [active] 169963006698 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 169963006699 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 169963006700 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 169963006701 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 169963006702 active site 169963006703 catalytic site [active] 169963006704 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 169963006705 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 169963006706 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 169963006707 DNA-binding site [nucleotide binding]; DNA binding site 169963006708 RNA-binding motif; other site 169963006709 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 169963006710 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 169963006711 active site 169963006712 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 169963006713 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 169963006714 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 169963006715 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 169963006716 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 169963006717 active site 169963006718 HIGH motif; other site 169963006719 KMSKS motif; other site 169963006720 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 169963006721 tRNA binding surface [nucleotide binding]; other site 169963006722 anticodon binding site; other site 169963006723 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 169963006724 DivIVA protein; Region: DivIVA; pfam05103 169963006725 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 169963006726 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 169963006727 HTH domain; Region: HTH_11; pfam08279 169963006728 3H domain; Region: 3H; pfam02829 169963006729 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 169963006730 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963006731 catalytic residue [active] 169963006732 L-aspartate oxidase; Provisional; Region: PRK08071 169963006733 L-aspartate oxidase; Provisional; Region: PRK06175 169963006734 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 169963006735 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 169963006736 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 169963006737 dimerization interface [polypeptide binding]; other site 169963006738 active site 169963006739 quinolinate synthetase; Provisional; Region: PRK09375 169963006740 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963006741 Leucine rich repeat; Region: LRR_8; pfam13855 169963006742 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963006743 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963006744 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 169963006745 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963006746 Leucine rich repeat; Region: LRR_8; pfam13855 169963006747 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963006748 Leucine rich repeat; Region: LRR_8; pfam13855 169963006749 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 169963006750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963006751 RNA binding surface [nucleotide binding]; other site 169963006752 YGGT family; Region: YGGT; pfam02325 169963006753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 169963006754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 169963006755 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 169963006756 catalytic residue [active] 169963006757 cell division protein FtsZ; Validated; Region: PRK09330 169963006758 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 169963006759 nucleotide binding site [chemical binding]; other site 169963006760 SulA interaction site; other site 169963006761 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 169963006762 Cell division protein FtsA; Region: FtsA; smart00842 169963006763 Cell division protein FtsA; Region: FtsA; pfam14450 169963006764 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 169963006765 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 169963006766 Cell division protein FtsQ; Region: FtsQ; pfam03799 169963006767 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 169963006768 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 169963006769 active site 169963006770 homodimer interface [polypeptide binding]; other site 169963006771 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 169963006772 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 169963006773 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 169963006774 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 169963006775 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 169963006776 Mg++ binding site [ion binding]; other site 169963006777 putative catalytic motif [active] 169963006778 putative substrate binding site [chemical binding]; other site 169963006779 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 169963006780 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 169963006781 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 169963006782 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 169963006783 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 169963006784 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 169963006785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 169963006786 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 169963006787 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 169963006788 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 169963006789 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 169963006790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 169963006791 MraZ protein; Region: MraZ; pfam02381 169963006792 MraZ protein; Region: MraZ; pfam02381 169963006793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963006794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963006795 putative substrate translocation pore; other site 169963006796 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 169963006797 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 169963006798 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 169963006799 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 169963006800 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 169963006801 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 169963006802 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 169963006803 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 169963006804 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 169963006805 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 169963006806 hypothetical protein; Provisional; Region: PRK13670 169963006807 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 169963006808 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 169963006809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963006810 Walker A/P-loop; other site 169963006811 ATP binding site [chemical binding]; other site 169963006812 Q-loop/lid; other site 169963006813 ABC transporter signature motif; other site 169963006814 Walker B; other site 169963006815 D-loop; other site 169963006816 H-loop/switch region; other site 169963006817 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 169963006818 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 169963006819 protein binding site [polypeptide binding]; other site 169963006820 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 169963006821 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 169963006822 active site 169963006823 (T/H)XGH motif; other site 169963006824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963006825 S-adenosylmethionine binding site [chemical binding]; other site 169963006826 hypothetical protein; Provisional; Region: PRK02886 169963006827 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 169963006828 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 169963006829 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 169963006830 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 169963006831 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 169963006832 putative active site [active] 169963006833 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 169963006834 Ion transport protein; Region: Ion_trans; pfam00520 169963006835 Ion channel; Region: Ion_trans_2; pfam07885 169963006836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 169963006837 MOSC domain; Region: MOSC; pfam03473 169963006838 3-alpha domain; Region: 3-alpha; pfam03475 169963006839 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 169963006840 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 169963006841 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 169963006842 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 169963006843 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 169963006844 active site 169963006845 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 169963006846 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 169963006847 ring oligomerisation interface [polypeptide binding]; other site 169963006848 ATP/Mg binding site [chemical binding]; other site 169963006849 stacking interactions; other site 169963006850 hinge regions; other site 169963006851 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 169963006852 oligomerisation interface [polypeptide binding]; other site 169963006853 mobile loop; other site 169963006854 roof hairpin; other site 169963006855 CAAX protease self-immunity; Region: Abi; pfam02517 169963006856 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 169963006857 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 169963006858 CoA binding domain; Region: CoA_binding; pfam02629 169963006859 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 169963006860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963006861 ABC transporter; Region: ABC_tran_2; pfam12848 169963006862 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963006863 Protein of unknown function (DUF342); Region: DUF342; cl19219 169963006864 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963006865 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 169963006866 UGMP family protein; Validated; Region: PRK09604 169963006867 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 169963006868 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 169963006869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963006870 Coenzyme A binding pocket [chemical binding]; other site 169963006871 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 169963006872 Glycoprotease family; Region: Peptidase_M22; pfam00814 169963006873 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 169963006874 camphor resistance protein CrcB; Provisional; Region: PRK14214 169963006875 camphor resistance protein CrcB; Provisional; Region: PRK14231 169963006876 Uncharacterized conserved protein [Function unknown]; Region: COG4832 169963006877 Phosphotransferase enzyme family; Region: APH; pfam01636 169963006878 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 169963006879 active site 169963006880 substrate binding site [chemical binding]; other site 169963006881 ATP binding site [chemical binding]; other site 169963006882 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 169963006883 Cna protein B-type domain; Region: Cna_B; pfam05738 169963006884 Cna protein B-type domain; Region: Cna_B; pfam05738 169963006885 Cna protein B-type domain; Region: Cna_B; pfam05738 169963006886 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963006887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963006888 non-specific DNA binding site [nucleotide binding]; other site 169963006889 salt bridge; other site 169963006890 sequence-specific DNA binding site [nucleotide binding]; other site 169963006891 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 169963006892 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 169963006893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963006894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963006895 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963006896 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 169963006897 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 169963006898 ANP binding site [chemical binding]; other site 169963006899 Substrate Binding Site II [chemical binding]; other site 169963006900 Substrate Binding Site I [chemical binding]; other site 169963006901 argininosuccinate lyase; Provisional; Region: PRK00855 169963006902 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 169963006903 active sites [active] 169963006904 tetramer interface [polypeptide binding]; other site 169963006905 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 169963006906 hypothetical protein; Provisional; Region: PRK06357 169963006907 active site 169963006908 intersubunit interface [polypeptide binding]; other site 169963006909 Zn2+ binding site [ion binding]; other site 169963006910 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 169963006911 putative substrate binding site [chemical binding]; other site 169963006912 putative ATP binding site [chemical binding]; other site 169963006913 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 169963006914 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 169963006915 active site 169963006916 P-loop; other site 169963006917 phosphorylation site [posttranslational modification] 169963006918 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963006919 active site 169963006920 phosphorylation site [posttranslational modification] 169963006921 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963006922 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963006923 PRD domain; Region: PRD; pfam00874 169963006924 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963006925 active site 169963006926 P-loop; other site 169963006927 phosphorylation site [posttranslational modification] 169963006928 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 169963006929 active site 169963006930 phosphorylation site [posttranslational modification] 169963006931 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 169963006932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963006933 DNA-binding site [nucleotide binding]; DNA binding site 169963006934 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963006935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963006936 homodimer interface [polypeptide binding]; other site 169963006937 catalytic residue [active] 169963006938 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 169963006939 active site 169963006940 multimer interface [polypeptide binding]; other site 169963006941 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 169963006942 predicted active site [active] 169963006943 catalytic triad [active] 169963006944 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 169963006945 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 169963006946 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 169963006947 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 169963006948 G1 box; other site 169963006949 GTP/Mg2+ binding site [chemical binding]; other site 169963006950 Switch I region; other site 169963006951 G2 box; other site 169963006952 G3 box; other site 169963006953 Switch II region; other site 169963006954 G4 box; other site 169963006955 G5 box; other site 169963006956 Nucleoside recognition; Region: Gate; pfam07670 169963006957 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 169963006958 Nucleoside recognition; Region: Gate; pfam07670 169963006959 Virus attachment protein p12 family; Region: P12; pfam12669 169963006960 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 169963006961 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 169963006962 putative active site [active] 169963006963 putative metal binding site [ion binding]; other site 169963006964 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963006965 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 169963006966 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963006967 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 169963006968 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 169963006969 active site 169963006970 dimer interface [polypeptide binding]; other site 169963006971 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 169963006972 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963006973 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 169963006974 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 169963006975 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 169963006976 dimer interface [polypeptide binding]; other site 169963006977 FMN binding site [chemical binding]; other site 169963006978 NADPH bind site [chemical binding]; other site 169963006979 Helix-turn-helix domain; Region: HTH_17; pfam12728 169963006980 putative heme peroxidase; Provisional; Region: PRK12276 169963006981 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963006982 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963006983 Walker A/P-loop; other site 169963006984 ATP binding site [chemical binding]; other site 169963006985 Q-loop/lid; other site 169963006986 ABC transporter signature motif; other site 169963006987 Walker B; other site 169963006988 D-loop; other site 169963006989 H-loop/switch region; other site 169963006990 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963006991 FtsX-like permease family; Region: FtsX; pfam02687 169963006992 FtsX-like permease family; Region: FtsX; pfam02687 169963006993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963006994 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963006995 Coenzyme A binding pocket [chemical binding]; other site 169963006996 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 169963006997 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 169963006998 active site 169963006999 substrate binding site [chemical binding]; other site 169963007000 metal binding site [ion binding]; metal-binding site 169963007001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 169963007002 YbbR-like protein; Region: YbbR; pfam07949 169963007003 YbbR-like protein; Region: YbbR; pfam07949 169963007004 YbbR-like protein; Region: YbbR; pfam07949 169963007005 Uncharacterized conserved protein [Function unknown]; Region: COG1624 169963007006 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 169963007007 maltose phosphorylase; Provisional; Region: PRK13807 169963007008 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 169963007009 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 169963007010 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 169963007011 Predicted integral membrane protein [Function unknown]; Region: COG5521 169963007012 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963007013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007014 dimer interface [polypeptide binding]; other site 169963007015 conserved gate region; other site 169963007016 putative PBP binding loops; other site 169963007017 ABC-ATPase subunit interface; other site 169963007018 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 169963007019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007020 dimer interface [polypeptide binding]; other site 169963007021 conserved gate region; other site 169963007022 putative PBP binding loops; other site 169963007023 ABC-ATPase subunit interface; other site 169963007024 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 169963007025 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 169963007026 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 169963007027 homodimer interface [polypeptide binding]; other site 169963007028 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 169963007029 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 169963007030 active site 169963007031 homodimer interface [polypeptide binding]; other site 169963007032 catalytic site [active] 169963007033 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 169963007034 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963007035 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963007036 DNA binding site [nucleotide binding] 169963007037 domain linker motif; other site 169963007038 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 169963007039 ligand binding site [chemical binding]; other site 169963007040 dimerization interface [polypeptide binding]; other site 169963007041 Amino acid permease; Region: AA_permease_2; pfam13520 169963007042 K+ potassium transporter; Region: K_trans; cl15781 169963007043 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963007044 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963007045 ligand binding site [chemical binding]; other site 169963007046 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963007047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 169963007048 ligand binding site [chemical binding]; other site 169963007049 flexible hinge region; other site 169963007050 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963007051 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 169963007052 intersubunit interface [polypeptide binding]; other site 169963007053 active site 169963007054 zinc binding site [ion binding]; other site 169963007055 Na+ binding site [ion binding]; other site 169963007056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 169963007057 intersubunit interface [polypeptide binding]; other site 169963007058 active site 169963007059 zinc binding site [ion binding]; other site 169963007060 Na+ binding site [ion binding]; other site 169963007061 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963007062 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963007063 active site 169963007064 P-loop; other site 169963007065 phosphorylation site [posttranslational modification] 169963007066 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963007067 active site 169963007068 phosphorylation site [posttranslational modification] 169963007069 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963007070 HTH domain; Region: HTH_11; pfam08279 169963007071 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963007072 PRD domain; Region: PRD; pfam00874 169963007073 PRD domain; Region: PRD; pfam00874 169963007074 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963007075 active site 169963007076 P-loop; other site 169963007077 phosphorylation site [posttranslational modification] 169963007078 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 169963007079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963007080 Walker A/P-loop; other site 169963007081 ATP binding site [chemical binding]; other site 169963007082 Q-loop/lid; other site 169963007083 ABC transporter signature motif; other site 169963007084 Walker B; other site 169963007085 D-loop; other site 169963007086 H-loop/switch region; other site 169963007087 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 169963007088 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 169963007089 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 169963007090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963007091 Coenzyme A binding pocket [chemical binding]; other site 169963007092 Transcriptional regulators [Transcription]; Region: GntR; COG1802 169963007093 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 169963007094 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 169963007095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 169963007096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963007097 DNA-binding site [nucleotide binding]; DNA binding site 169963007098 UTRA domain; Region: UTRA; pfam07702 169963007099 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 169963007100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963007101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963007102 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 169963007103 putative dimerization interface [polypeptide binding]; other site 169963007104 Predicted membrane protein [Function unknown]; Region: COG2855 169963007105 Predicted membrane protein [Function unknown]; Region: COG4330 169963007106 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 169963007107 putative metal binding site [ion binding]; other site 169963007108 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 169963007109 homodimer interface [polypeptide binding]; other site 169963007110 chemical substrate binding site [chemical binding]; other site 169963007111 oligomer interface [polypeptide binding]; other site 169963007112 metal binding site [ion binding]; metal-binding site 169963007113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963007114 catalytic residues [active] 169963007115 flavodoxin; Provisional; Region: PRK09271 169963007116 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 169963007117 dimer interface [polypeptide binding]; other site 169963007118 putative radical transfer pathway; other site 169963007119 diiron center [ion binding]; other site 169963007120 tyrosyl radical; other site 169963007121 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 169963007122 Class I ribonucleotide reductase; Region: RNR_I; cd01679 169963007123 active site 169963007124 dimer interface [polypeptide binding]; other site 169963007125 catalytic residues [active] 169963007126 effector binding site; other site 169963007127 R2 peptide binding site; other site 169963007128 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 169963007129 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 169963007130 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 169963007131 Alkyl sulfatase dimerization; Region: Alkyl_sulf_dimr; pfam14863 169963007132 Alkyl sulfatase C-terminal; Region: Alkyl_sulf_C; pfam14864 169963007133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 169963007134 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963007135 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963007136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963007137 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 169963007138 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 169963007139 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 169963007140 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 169963007141 conserved cys residue [active] 169963007142 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 169963007143 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 169963007144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963007145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963007146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963007147 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 169963007148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963007149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 169963007150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963007151 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963007152 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 169963007153 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963007154 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963007155 ligand binding site [chemical binding]; other site 169963007156 flexible hinge region; other site 169963007157 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 169963007158 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 169963007159 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 169963007160 dimer interface [polypeptide binding]; other site 169963007161 active site 169963007162 metal binding site [ion binding]; metal-binding site 169963007163 glutathione binding site [chemical binding]; other site 169963007164 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 169963007165 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 169963007166 FMN binding site [chemical binding]; other site 169963007167 substrate binding site [chemical binding]; other site 169963007168 putative catalytic residue [active] 169963007169 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 169963007170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963007171 putative substrate translocation pore; other site 169963007172 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 169963007173 Coenzyme A transferase; Region: CoA_trans; smart00882 169963007174 Coenzyme A transferase; Region: CoA_trans; cl17247 169963007175 PAS fold; Region: PAS; pfam00989 169963007176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963007177 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 169963007178 Walker A motif; other site 169963007179 ATP binding site [chemical binding]; other site 169963007180 Walker B motif; other site 169963007181 arginine finger; other site 169963007182 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 169963007183 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 169963007184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 169963007185 metal binding site [ion binding]; metal-binding site 169963007186 active site 169963007187 I-site; other site 169963007188 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 169963007189 classical (c) SDRs; Region: SDR_c; cd05233 169963007190 NAD(P) binding site [chemical binding]; other site 169963007191 active site 169963007192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963007193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963007194 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 169963007195 Tic20-like protein; Region: Tic20; pfam09685 169963007196 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 169963007197 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007198 Collagen binding domain; Region: Collagen_bind; pfam05737 169963007199 Collagen binding domain; Region: Collagen_bind; pfam05737 169963007200 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007201 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007202 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007203 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007204 Cna protein B-type domain; Region: Cna_B; pfam05738 169963007205 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007206 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007207 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007208 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 169963007209 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 169963007210 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 169963007211 active site 169963007212 catalytic site [active] 169963007213 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 169963007214 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 169963007215 Walker A/P-loop; other site 169963007216 ATP binding site [chemical binding]; other site 169963007217 Q-loop/lid; other site 169963007218 ABC transporter signature motif; other site 169963007219 Walker B; other site 169963007220 D-loop; other site 169963007221 H-loop/switch region; other site 169963007222 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963007223 ABC-ATPase subunit interface; other site 169963007224 dimer interface [polypeptide binding]; other site 169963007225 putative PBP binding regions; other site 169963007226 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 169963007227 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 169963007228 putative ligand binding residues [chemical binding]; other site 169963007229 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 169963007230 heme-binding site [chemical binding]; other site 169963007231 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 169963007232 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 169963007233 heme-binding site [chemical binding]; other site 169963007234 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 169963007235 heme-binding site [chemical binding]; other site 169963007236 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 169963007237 heme uptake protein IsdC; Region: IsdC; TIGR03656 169963007238 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 169963007239 heme-binding site [chemical binding]; other site 169963007240 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 169963007241 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 169963007242 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 169963007243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 169963007244 active site 169963007245 Zn binding site [ion binding]; other site 169963007246 Competence protein CoiA-like family; Region: CoiA; cl11541 169963007247 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 169963007248 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 169963007249 putative catalytic residues [active] 169963007250 thiol/disulfide switch; other site 169963007251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 169963007252 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 169963007253 Walker A/P-loop; other site 169963007254 ATP binding site [chemical binding]; other site 169963007255 Q-loop/lid; other site 169963007256 ABC transporter signature motif; other site 169963007257 Walker B; other site 169963007258 D-loop; other site 169963007259 H-loop/switch region; other site 169963007260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 169963007261 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 169963007262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 169963007263 Walker A/P-loop; other site 169963007264 ATP binding site [chemical binding]; other site 169963007265 Q-loop/lid; other site 169963007266 ABC transporter signature motif; other site 169963007267 Walker B; other site 169963007268 D-loop; other site 169963007269 H-loop/switch region; other site 169963007270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 169963007271 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 169963007272 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 169963007273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007274 dimer interface [polypeptide binding]; other site 169963007275 conserved gate region; other site 169963007276 putative PBP binding loops; other site 169963007277 ABC-ATPase subunit interface; other site 169963007278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 169963007279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007280 dimer interface [polypeptide binding]; other site 169963007281 conserved gate region; other site 169963007282 putative PBP binding loops; other site 169963007283 ABC-ATPase subunit interface; other site 169963007284 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 169963007285 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 169963007286 peptide binding site [polypeptide binding]; other site 169963007287 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 169963007288 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 169963007289 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 169963007290 active site 169963007291 HIGH motif; other site 169963007292 dimer interface [polypeptide binding]; other site 169963007293 KMSKS motif; other site 169963007294 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 169963007295 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963007296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 169963007297 putative DNA binding site [nucleotide binding]; other site 169963007298 putative Zn2+ binding site [ion binding]; other site 169963007299 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 169963007300 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 169963007301 dimer interface [polypeptide binding]; other site 169963007302 active site 169963007303 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 169963007304 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 169963007305 dimer interface [polypeptide binding]; other site 169963007306 active site 169963007307 CoA binding pocket [chemical binding]; other site 169963007308 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963007309 SH3-like domain; Region: SH3_8; pfam13457 169963007310 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 169963007311 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 169963007312 catalytic core [active] 169963007313 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 169963007314 Clp amino terminal domain; Region: Clp_N; pfam02861 169963007315 Clp amino terminal domain; Region: Clp_N; pfam02861 169963007316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963007317 Walker A motif; other site 169963007318 ATP binding site [chemical binding]; other site 169963007319 Walker B motif; other site 169963007320 arginine finger; other site 169963007321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963007322 Walker A motif; other site 169963007323 ATP binding site [chemical binding]; other site 169963007324 Walker B motif; other site 169963007325 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 169963007326 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 169963007327 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963007328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007329 active site 169963007330 motif I; other site 169963007331 motif II; other site 169963007332 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963007333 Predicted acetyltransferase [General function prediction only]; Region: COG3393 169963007334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 169963007335 ferrochelatase; Provisional; Region: PRK12435 169963007336 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 169963007337 C-terminal domain interface [polypeptide binding]; other site 169963007338 active site 169963007339 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 169963007340 active site 169963007341 N-terminal domain interface [polypeptide binding]; other site 169963007342 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 169963007343 substrate binding site [chemical binding]; other site 169963007344 active site 169963007345 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 169963007346 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 169963007347 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 169963007348 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963007349 Walker A/P-loop; other site 169963007350 ATP binding site [chemical binding]; other site 169963007351 Q-loop/lid; other site 169963007352 ABC transporter signature motif; other site 169963007353 Walker B; other site 169963007354 D-loop; other site 169963007355 H-loop/switch region; other site 169963007356 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 169963007357 HIT family signature motif; other site 169963007358 catalytic residue [active] 169963007359 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 169963007360 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 169963007361 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 169963007362 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 169963007363 SurA N-terminal domain; Region: SurA_N_3; cl07813 169963007364 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 169963007365 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 169963007366 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 169963007367 generic binding surface II; other site 169963007368 generic binding surface I; other site 169963007369 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963007370 Zn2+ binding site [ion binding]; other site 169963007371 Mg2+ binding site [ion binding]; other site 169963007372 Uncharacterized conserved protein [Function unknown]; Region: COG4717 169963007373 AAA domain; Region: AAA_23; pfam13476 169963007374 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 169963007375 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 169963007376 active site 169963007377 metal binding site [ion binding]; metal-binding site 169963007378 DNA binding site [nucleotide binding] 169963007379 hypothetical protein; Provisional; Region: PRK13676 169963007380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 169963007381 Protein of unknown function (DUF445); Region: DUF445; pfam04286 169963007382 fumarate hydratase; Reviewed; Region: fumC; PRK00485 169963007383 Class II fumarases; Region: Fumarase_classII; cd01362 169963007384 active site 169963007385 tetramer interface [polypeptide binding]; other site 169963007386 Acyltransferase family; Region: Acyl_transf_3; cl19154 169963007387 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 169963007388 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963007389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963007390 Walker A/P-loop; other site 169963007391 ATP binding site [chemical binding]; other site 169963007392 Q-loop/lid; other site 169963007393 ABC transporter signature motif; other site 169963007394 Walker B; other site 169963007395 D-loop; other site 169963007396 H-loop/switch region; other site 169963007397 Transglycosylase; Region: Transgly; pfam00912 169963007398 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 169963007399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 169963007400 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 169963007401 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 169963007402 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 169963007403 Domain of unknown function DUF21; Region: DUF21; pfam01595 169963007404 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 169963007405 Transporter associated domain; Region: CorC_HlyC; smart01091 169963007406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963007407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963007408 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 169963007409 putative dimerization interface [polypeptide binding]; other site 169963007410 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 169963007411 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 169963007412 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 169963007413 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 169963007414 active site 169963007415 FMN binding site [chemical binding]; other site 169963007416 substrate binding site [chemical binding]; other site 169963007417 putative catalytic residue [active] 169963007418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963007419 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 169963007420 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 169963007421 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 169963007422 shikimate binding site; other site 169963007423 NAD(P) binding site [chemical binding]; other site 169963007424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963007425 putative substrate translocation pore; other site 169963007426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963007427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963007428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963007429 putative substrate translocation pore; other site 169963007430 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963007431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963007432 Walker A/P-loop; other site 169963007433 ATP binding site [chemical binding]; other site 169963007434 Q-loop/lid; other site 169963007435 ABC transporter signature motif; other site 169963007436 Walker B; other site 169963007437 D-loop; other site 169963007438 H-loop/switch region; other site 169963007439 Predicted transcriptional regulators [Transcription]; Region: COG1725 169963007440 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 169963007441 DNA-binding site [nucleotide binding]; DNA binding site 169963007442 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 169963007443 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 169963007444 DNA binding site [nucleotide binding] 169963007445 active site 169963007446 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 169963007447 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 169963007448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963007449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963007450 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 169963007451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 169963007452 active site 169963007453 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 169963007454 putative dimer interface [polypeptide binding]; other site 169963007455 ligand binding site [chemical binding]; other site 169963007456 Zn binding site [ion binding]; other site 169963007457 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 169963007458 active site 169963007459 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963007460 active site 169963007461 catalytic tetrad [active] 169963007462 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 169963007463 TIGR00153 family protein; Region: TIGR00153 169963007464 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 169963007465 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 169963007466 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 169963007467 substrate binding pocket [chemical binding]; other site 169963007468 membrane-bound complex binding site; other site 169963007469 hinge residues; other site 169963007470 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963007471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007472 dimer interface [polypeptide binding]; other site 169963007473 conserved gate region; other site 169963007474 putative PBP binding loops; other site 169963007475 ABC-ATPase subunit interface; other site 169963007476 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 169963007477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 169963007478 Walker A/P-loop; other site 169963007479 ATP binding site [chemical binding]; other site 169963007480 Q-loop/lid; other site 169963007481 ABC transporter signature motif; other site 169963007482 Walker B; other site 169963007483 D-loop; other site 169963007484 H-loop/switch region; other site 169963007485 aspartate aminotransferase; Provisional; Region: PRK06348 169963007486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963007487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963007488 homodimer interface [polypeptide binding]; other site 169963007489 catalytic residue [active] 169963007490 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 169963007491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007492 active site 169963007493 motif I; other site 169963007494 motif II; other site 169963007495 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 169963007496 Sulfate transporter family; Region: Sulfate_transp; cl19250 169963007497 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 169963007498 intracellular protease, PfpI family; Region: PfpI; TIGR01382 169963007499 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 169963007500 proposed catalytic triad [active] 169963007501 conserved cys residue [active] 169963007502 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 169963007503 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963007504 methionine cluster; other site 169963007505 active site 169963007506 phosphorylation site [posttranslational modification] 169963007507 metal binding site [ion binding]; metal-binding site 169963007508 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963007509 Coenzyme A binding pocket [chemical binding]; other site 169963007510 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963007511 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 169963007512 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 169963007513 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963007514 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963007515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007516 active site 169963007517 motif I; other site 169963007518 motif II; other site 169963007519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007520 Uncharacterized conserved protein [Function unknown]; Region: COG1284 169963007521 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963007522 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963007523 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 169963007524 hypothetical protein; Provisional; Region: PRK13673 169963007525 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 169963007526 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 169963007527 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 169963007528 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 169963007529 Part of AAA domain; Region: AAA_19; pfam13245 169963007530 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 169963007531 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 169963007532 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 169963007533 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl19914 169963007534 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 169963007535 IDEAL domain; Region: IDEAL; pfam08858 169963007536 ComK protein; Region: ComK; cl11560 169963007537 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 169963007538 AP2 domain; Region: AP2; pfam00847 169963007539 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 169963007540 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 169963007541 Phage holin; Region: Phage_holin_5; pfam06946 169963007542 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 169963007543 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 169963007544 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cd00890 169963007545 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 169963007546 Phage tail protein; Region: Sipho_tail; pfam05709 169963007547 tape measure domain; Region: tape_meas_nterm; TIGR02675 169963007548 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 169963007549 Phage protein Gp14; Region: Phage_Gp14; pfam10666 169963007550 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 169963007551 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 169963007552 Minor capsid protein; Region: Minor_capsid_2; pfam11114 169963007553 Minor capsid protein; Region: Minor_capsid_1; pfam10665 169963007554 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 169963007555 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 169963007556 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 169963007557 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; cl19531 169963007558 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 169963007559 Phage terminase large subunit; Region: Terminase_3; pfam04466 169963007560 Terminase-like family; Region: Terminase_6; pfam03237 169963007561 Terminase small subunit; Region: Terminase_2; cl01513 169963007562 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 169963007563 Protein of unknown function (DUF2481); Region: DUF2481; pfam10654 169963007564 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 169963007565 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 169963007566 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 169963007567 dimer interface [polypeptide binding]; other site 169963007568 ssDNA binding site [nucleotide binding]; other site 169963007569 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963007570 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 169963007571 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 169963007572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 169963007573 phage uncharacterized protein TIGR01671; Region: phage_TIGR01671 169963007574 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 169963007575 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 169963007576 N-terminal phage replisome organizer (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 169963007577 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 169963007578 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 169963007579 ERF superfamily; Region: ERF; pfam04404 169963007580 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 169963007581 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 169963007582 AntA/AntB antirepressor; Region: AntA; pfam08346 169963007583 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 169963007584 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963007585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963007586 non-specific DNA binding site [nucleotide binding]; other site 169963007587 salt bridge; other site 169963007588 sequence-specific DNA binding site [nucleotide binding]; other site 169963007589 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963007590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963007591 non-specific DNA binding site [nucleotide binding]; other site 169963007592 salt bridge; other site 169963007593 sequence-specific DNA binding site [nucleotide binding]; other site 169963007594 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 169963007595 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 169963007596 catalytic residues [active] 169963007597 catalytic nucleophile [active] 169963007598 Presynaptic Site I dimer interface [polypeptide binding]; other site 169963007599 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 169963007600 Synaptic Flat tetramer interface [polypeptide binding]; other site 169963007601 Synaptic Site I dimer interface [polypeptide binding]; other site 169963007602 DNA binding site [nucleotide binding] 169963007603 Recombinase; Region: Recombinase; pfam07508 169963007604 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 169963007605 ComK protein; Region: ComK; cl11560 169963007607 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963007608 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963007609 non-specific DNA binding site [nucleotide binding]; other site 169963007610 salt bridge; other site 169963007611 sequence-specific DNA binding site [nucleotide binding]; other site 169963007612 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 169963007613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963007614 active site 169963007615 phosphorylation site [posttranslational modification] 169963007616 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963007617 active site 169963007618 P-loop; other site 169963007619 phosphorylation site [posttranslational modification] 169963007620 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963007621 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 169963007622 putative substrate binding site [chemical binding]; other site 169963007623 putative ATP binding site [chemical binding]; other site 169963007624 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963007625 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 169963007626 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963007627 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 169963007628 trimer interface [polypeptide binding]; other site 169963007629 active site 169963007630 G bulge; other site 169963007631 Uncharacterized conserved protein [Function unknown]; Region: COG1683 169963007632 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 169963007633 putative kinase; Provisional; Region: PRK09954 169963007634 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 169963007635 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 169963007636 substrate binding site [chemical binding]; other site 169963007637 ATP binding site [chemical binding]; other site 169963007638 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 169963007639 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 169963007640 RNA binding surface [nucleotide binding]; other site 169963007641 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 169963007642 active site 169963007643 uracil binding [chemical binding]; other site 169963007644 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 169963007645 active site 169963007646 non-prolyl cis peptide bond; other site 169963007647 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 169963007648 catalytic residues [active] 169963007649 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 169963007650 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 169963007651 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 169963007652 Walker A/P-loop; other site 169963007653 ATP binding site [chemical binding]; other site 169963007654 Q-loop/lid; other site 169963007655 ABC transporter signature motif; other site 169963007656 Walker B; other site 169963007657 D-loop; other site 169963007658 H-loop/switch region; other site 169963007659 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963007660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007661 dimer interface [polypeptide binding]; other site 169963007662 conserved gate region; other site 169963007663 putative PBP binding loops; other site 169963007664 ABC-ATPase subunit interface; other site 169963007665 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 169963007666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007667 dimer interface [polypeptide binding]; other site 169963007668 conserved gate region; other site 169963007669 putative PBP binding loops; other site 169963007670 ABC-ATPase subunit interface; other site 169963007671 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 169963007672 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 169963007673 substrate binding pocket [chemical binding]; other site 169963007674 membrane-bound complex binding site; other site 169963007675 hinge residues; other site 169963007676 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 169963007677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963007678 Coenzyme A binding pocket [chemical binding]; other site 169963007679 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 169963007680 Transcriptional regulator [Transcription]; Region: LysR; COG0583 169963007681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 169963007682 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 169963007683 dimerization interface [polypeptide binding]; other site 169963007684 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 169963007685 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 169963007686 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 169963007687 active site 169963007688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963007689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963007690 putative substrate translocation pore; other site 169963007691 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 169963007692 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 169963007693 active site 169963007694 trimer interface [polypeptide binding]; other site 169963007695 allosteric site; other site 169963007696 active site lid [active] 169963007697 hexamer (dimer of trimers) interface [polypeptide binding]; other site 169963007698 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963007699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007700 active site 169963007701 motif I; other site 169963007702 motif II; other site 169963007703 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963007704 Predicted membrane protein [Function unknown]; Region: COG1511 169963007705 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 169963007706 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 169963007707 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 169963007708 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 169963007709 Predicted transcriptional regulator [Transcription]; Region: COG1959 169963007710 Rrf2 family protein; Region: rrf2_super; TIGR00738 169963007711 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 169963007712 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 169963007713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963007714 catalytic residue [active] 169963007715 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 169963007716 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963007717 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 169963007718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 169963007719 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 169963007720 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 169963007721 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 169963007722 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 169963007723 active site 169963007724 dimer interface [polypeptide binding]; other site 169963007725 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 169963007726 dimer interface [polypeptide binding]; other site 169963007727 active site 169963007728 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 169963007729 nudix motif; other site 169963007730 general stress protein 13; Validated; Region: PRK08059 169963007731 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 169963007732 RNA binding site [nucleotide binding]; other site 169963007733 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 169963007734 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 169963007735 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963007736 homodimer interface [polypeptide binding]; other site 169963007737 catalytic residue [active] 169963007738 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963007739 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963007740 FtsX-like permease family; Region: FtsX; pfam02687 169963007741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963007742 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963007743 Walker A/P-loop; other site 169963007744 ATP binding site [chemical binding]; other site 169963007745 Q-loop/lid; other site 169963007746 ABC transporter signature motif; other site 169963007747 Walker B; other site 169963007748 D-loop; other site 169963007749 H-loop/switch region; other site 169963007750 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963007751 active site 169963007752 P-loop; other site 169963007753 phosphorylation site [posttranslational modification] 169963007754 aspartate kinase; Reviewed; Region: PRK09034 169963007755 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 169963007756 putative catalytic residues [active] 169963007757 putative nucleotide binding site [chemical binding]; other site 169963007758 putative aspartate binding site [chemical binding]; other site 169963007759 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 169963007760 allosteric regulatory residue; other site 169963007761 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 169963007762 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 169963007763 active site 169963007764 drug efflux system protein MdtG; Provisional; Region: PRK09874 169963007765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963007766 putative substrate translocation pore; other site 169963007767 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 169963007768 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 169963007769 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 169963007770 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 169963007771 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 169963007772 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 169963007773 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 169963007774 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 169963007775 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 169963007776 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 169963007777 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 169963007778 CoenzymeA binding site [chemical binding]; other site 169963007779 subunit interaction site [polypeptide binding]; other site 169963007780 PHB binding site; other site 169963007781 Divergent PAP2 family; Region: DUF212; pfam02681 169963007782 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 169963007783 Cl- selectivity filter; other site 169963007784 Cl- binding residues [ion binding]; other site 169963007785 pore gating glutamate residue; other site 169963007786 dimer interface [polypeptide binding]; other site 169963007787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 169963007788 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 169963007789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963007790 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 169963007791 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963007792 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963007793 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 169963007794 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 169963007795 NAD(P) binding site [chemical binding]; other site 169963007796 putative active site [active] 169963007797 hypothetical protein; Provisional; Region: PRK13669 169963007798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 169963007799 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963007800 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963007801 Leucine-rich repeats; other site 169963007802 Substrate binding site [chemical binding]; other site 169963007803 Leucine rich repeat; Region: LRR_8; pfam13855 169963007804 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963007805 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963007806 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007807 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007808 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007809 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007810 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007811 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007812 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963007813 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 169963007814 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 169963007815 tetramer interfaces [polypeptide binding]; other site 169963007816 binuclear metal-binding site [ion binding]; other site 169963007817 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 169963007818 Domain of unknown function DUF21; Region: DUF21; pfam01595 169963007819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 169963007820 Transporter associated domain; Region: CorC_HlyC; smart01091 169963007821 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 169963007822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963007823 Coenzyme A binding pocket [chemical binding]; other site 169963007824 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 169963007825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963007826 active site 169963007827 motif I; other site 169963007828 motif II; other site 169963007829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 169963007830 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 169963007831 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 169963007832 active site 169963007833 metal binding site [ion binding]; metal-binding site 169963007834 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 169963007835 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 169963007836 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 169963007837 Uncharacterized conserved protein [Function unknown]; Region: COG1801 169963007838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963007839 non-specific DNA binding site [nucleotide binding]; other site 169963007840 salt bridge; other site 169963007841 sequence-specific DNA binding site [nucleotide binding]; other site 169963007842 FeS assembly protein SufB; Region: sufB; TIGR01980 169963007843 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 169963007844 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 169963007845 trimerization site [polypeptide binding]; other site 169963007846 active site 169963007847 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 169963007848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963007849 catalytic residue [active] 169963007850 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 169963007851 FeS assembly protein SufD; Region: sufD; TIGR01981 169963007852 FeS assembly ATPase SufC; Region: sufC; TIGR01978 169963007853 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 169963007854 Walker A/P-loop; other site 169963007855 ATP binding site [chemical binding]; other site 169963007856 Q-loop/lid; other site 169963007857 ABC transporter signature motif; other site 169963007858 Walker B; other site 169963007859 D-loop; other site 169963007860 H-loop/switch region; other site 169963007861 flagellar hook-associated protein FlgK; Provisional; Region: flgK; PRK12714 169963007862 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 169963007863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963007864 dimer interface [polypeptide binding]; other site 169963007865 conserved gate region; other site 169963007866 putative PBP binding loops; other site 169963007867 ABC-ATPase subunit interface; other site 169963007868 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 169963007869 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 169963007870 Walker A/P-loop; other site 169963007871 ATP binding site [chemical binding]; other site 169963007872 Q-loop/lid; other site 169963007873 ABC transporter signature motif; other site 169963007874 Walker B; other site 169963007875 D-loop; other site 169963007876 H-loop/switch region; other site 169963007877 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 169963007878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 169963007879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963007880 dimer interface [polypeptide binding]; other site 169963007881 phosphorylation site [posttranslational modification] 169963007882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963007883 ATP binding site [chemical binding]; other site 169963007884 Mg2+ binding site [ion binding]; other site 169963007885 G-X-G motif; other site 169963007886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963007887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963007888 active site 169963007889 phosphorylation site [posttranslational modification] 169963007890 intermolecular recognition site; other site 169963007891 dimerization interface [polypeptide binding]; other site 169963007892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963007893 DNA binding site [nucleotide binding] 169963007894 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 169963007895 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963007896 catalytic residues [active] 169963007897 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 169963007898 lipoyl attachment site [posttranslational modification]; other site 169963007899 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 169963007900 putative ArsC-like catalytic residues; other site 169963007901 putative TRX-like catalytic residues [active] 169963007902 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 169963007903 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 169963007904 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 169963007905 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 169963007906 Walker A/P-loop; other site 169963007907 ATP binding site [chemical binding]; other site 169963007908 Q-loop/lid; other site 169963007909 ABC transporter signature motif; other site 169963007910 Walker B; other site 169963007911 D-loop; other site 169963007912 H-loop/switch region; other site 169963007913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 169963007914 ABC-ATPase subunit interface; other site 169963007915 dimer interface [polypeptide binding]; other site 169963007916 putative PBP binding regions; other site 169963007917 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 169963007918 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 169963007919 intersubunit interface [polypeptide binding]; other site 169963007920 Predicted esterase [General function prediction only]; Region: COG0627 169963007921 S-formylglutathione hydrolase; Region: PLN02442 169963007922 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 169963007923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963007924 catalytic residue [active] 169963007925 SdpI/YhfL protein family; Region: SdpI; pfam13630 169963007926 transcriptional antiterminator BglG; Provisional; Region: PRK09772 169963007927 CAT RNA binding domain; Region: CAT_RBD; smart01061 169963007928 PRD domain; Region: PRD; pfam00874 169963007929 PRD domain; Region: PRD; pfam00874 169963007930 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 169963007931 Uncharacterized conserved protein [Function unknown]; Region: COG4283 169963007932 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 169963007933 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 169963007934 Predicted transcriptional regulator [Transcription]; Region: COG2378 169963007935 HTH domain; Region: HTH_11; pfam08279 169963007936 WYL domain; Region: WYL; pfam13280 169963007937 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 169963007938 putative active site [active] 169963007939 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 169963007940 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 169963007941 active site 169963007942 catalytic site [active] 169963007943 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 169963007944 putative metal binding site [ion binding]; other site 169963007945 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 169963007946 putative metal binding site [ion binding]; other site 169963007947 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963007948 Leucine rich repeat; Region: LRR_8; pfam13855 169963007949 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 169963007950 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 169963007951 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 169963007952 active site 169963007953 catalytic site [active] 169963007954 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 169963007955 putative metal binding site [ion binding]; other site 169963007956 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963007957 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963007958 non-specific DNA binding site [nucleotide binding]; other site 169963007959 salt bridge; other site 169963007960 sequence-specific DNA binding site [nucleotide binding]; other site 169963007961 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 169963007962 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 169963007963 SmpB-tmRNA interface; other site 169963007964 ribonuclease R; Region: RNase_R; TIGR02063 169963007965 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 169963007966 RNB domain; Region: RNB; pfam00773 169963007967 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 169963007968 RNA binding site [nucleotide binding]; other site 169963007969 Esterase/lipase [General function prediction only]; Region: COG1647 169963007970 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963007971 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963007972 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 169963007973 Esterase/lipase [General function prediction only]; Region: COG1647 169963007974 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963007975 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 169963007976 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963007977 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 169963007978 enolase; Provisional; Region: eno; PRK00077 169963007979 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 169963007980 dimer interface [polypeptide binding]; other site 169963007981 metal binding site [ion binding]; metal-binding site 169963007982 substrate binding pocket [chemical binding]; other site 169963007983 phosphoglyceromutase; Provisional; Region: PRK05434 169963007984 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 169963007985 substrate binding site [chemical binding]; other site 169963007986 dimer interface [polypeptide binding]; other site 169963007987 catalytic triad [active] 169963007988 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 169963007989 substrate binding site [chemical binding]; other site 169963007990 hinge regions; other site 169963007991 ADP binding site [chemical binding]; other site 169963007992 catalytic site [active] 169963007993 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 169963007994 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 169963007995 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 169963007996 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 169963007997 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 169963007998 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 169963007999 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 169963008000 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 169963008001 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 169963008002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963008003 DNA binding site [nucleotide binding] 169963008004 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 169963008005 active site 169963008006 dimer interface [polypeptide binding]; other site 169963008007 Transport protein; Region: actII; TIGR00833 169963008008 MMPL family; Region: MMPL; cl14618 169963008009 MMPL family; Region: MMPL; cl14618 169963008010 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963008011 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963008012 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 169963008013 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 169963008014 Chitin binding domain; Region: Chitin_bind_3; pfam03067 169963008015 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 169963008016 Interdomain contacts; other site 169963008017 Cytokine receptor motif; other site 169963008018 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 169963008019 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 169963008020 Interdomain contacts; other site 169963008021 Cytokine receptor motif; other site 169963008022 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 169963008023 aromatic chitin/cellulose binding site residues [chemical binding]; other site 169963008024 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 169963008025 aromatic chitin/cellulose binding site residues [chemical binding]; other site 169963008026 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 169963008027 oligomer interface [polypeptide binding]; other site 169963008028 active site residues [active] 169963008029 amino acid transporter; Region: 2A0306; TIGR00909 169963008030 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 169963008031 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 169963008032 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 169963008033 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963008034 Substrate binding site [chemical binding]; other site 169963008035 Leucine rich repeat; Region: LRR_8; pfam13855 169963008036 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 169963008037 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 169963008038 active site 169963008039 FMN binding site [chemical binding]; other site 169963008040 substrate binding site [chemical binding]; other site 169963008041 homotetramer interface [polypeptide binding]; other site 169963008042 catalytic residue [active] 169963008043 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 169963008044 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 169963008045 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 169963008046 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 169963008047 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 169963008048 phosphate binding site [ion binding]; other site 169963008049 putative substrate binding pocket [chemical binding]; other site 169963008050 dimer interface [polypeptide binding]; other site 169963008051 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 169963008052 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 169963008053 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 169963008054 active site 169963008055 substrate binding site [chemical binding]; other site 169963008056 metal binding site [ion binding]; metal-binding site 169963008057 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 169963008058 active site 169963008059 catalytic residues [active] 169963008060 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 169963008061 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 169963008062 NAD binding site [chemical binding]; other site 169963008063 homodimer interface [polypeptide binding]; other site 169963008064 active site 169963008065 substrate binding site [chemical binding]; other site 169963008066 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 169963008067 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 169963008068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963008069 TPR repeat; Region: TPR_11; pfam13414 169963008070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963008071 binding surface 169963008072 TPR motif; other site 169963008073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 169963008074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 169963008075 binding surface 169963008076 TPR motif; other site 169963008077 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 169963008078 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 169963008079 trimer interface [polypeptide binding]; other site 169963008080 active site 169963008081 substrate binding site [chemical binding]; other site 169963008082 CoA binding site [chemical binding]; other site 169963008083 pyrophosphatase PpaX; Provisional; Region: PRK13288 169963008084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963008085 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963008086 active site 169963008087 motif I; other site 169963008088 motif II; other site 169963008089 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 169963008090 HPr kinase/phosphorylase; Provisional; Region: PRK05428 169963008091 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 169963008092 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 169963008093 Hpr binding site; other site 169963008094 active site 169963008095 homohexamer subunit interaction site [polypeptide binding]; other site 169963008096 Predicted membrane protein [Function unknown]; Region: COG1950 169963008097 PspC domain; Region: PspC; pfam04024 169963008098 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 169963008099 Uncharacterized conserved protein [Function unknown]; Region: COG3595 169963008100 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 169963008101 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 169963008102 Uncharacterized conserved protein [Function unknown]; Region: COG3595 169963008103 Domain of unknown function (DUF4098); Region: DUF4098; cl19992 169963008104 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 169963008105 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 169963008106 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 169963008107 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 169963008108 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 169963008109 excinuclease ABC subunit B; Provisional; Region: PRK05298 169963008110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963008111 ATP binding site [chemical binding]; other site 169963008112 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 169963008113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963008114 nucleotide binding region [chemical binding]; other site 169963008115 ATP-binding site [chemical binding]; other site 169963008116 Ultra-violet resistance protein B; Region: UvrB; pfam12344 169963008117 UvrB/uvrC motif; Region: UVR; pfam02151 169963008118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 169963008119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963008120 Zn2+ binding site [ion binding]; other site 169963008121 Mg2+ binding site [ion binding]; other site 169963008122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 169963008123 dimerization interface [polypeptide binding]; other site 169963008124 putative DNA binding site [nucleotide binding]; other site 169963008125 putative Zn2+ binding site [ion binding]; other site 169963008126 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 169963008127 PhoU domain; Region: PhoU; pfam01895 169963008128 PhoU domain; Region: PhoU; pfam01895 169963008129 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 169963008130 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 169963008131 Walker A/P-loop; other site 169963008132 ATP binding site [chemical binding]; other site 169963008133 Q-loop/lid; other site 169963008134 ABC transporter signature motif; other site 169963008135 Walker B; other site 169963008136 D-loop; other site 169963008137 H-loop/switch region; other site 169963008138 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 169963008139 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 169963008140 Walker A/P-loop; other site 169963008141 ATP binding site [chemical binding]; other site 169963008142 Q-loop/lid; other site 169963008143 ABC transporter signature motif; other site 169963008144 Walker B; other site 169963008145 D-loop; other site 169963008146 H-loop/switch region; other site 169963008147 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 169963008148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963008149 dimer interface [polypeptide binding]; other site 169963008150 conserved gate region; other site 169963008151 putative PBP binding loops; other site 169963008152 ABC-ATPase subunit interface; other site 169963008153 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 169963008154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963008155 dimer interface [polypeptide binding]; other site 169963008156 conserved gate region; other site 169963008157 putative PBP binding loops; other site 169963008158 ABC-ATPase subunit interface; other site 169963008159 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 169963008160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 169963008161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963008162 dimerization interface [polypeptide binding]; other site 169963008163 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 169963008164 putative active site [active] 169963008165 heme pocket [chemical binding]; other site 169963008166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963008167 dimer interface [polypeptide binding]; other site 169963008168 phosphorylation site [posttranslational modification] 169963008169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963008170 ATP binding site [chemical binding]; other site 169963008171 Mg2+ binding site [ion binding]; other site 169963008172 G-X-G motif; other site 169963008173 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963008174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963008175 active site 169963008176 phosphorylation site [posttranslational modification] 169963008177 intermolecular recognition site; other site 169963008178 dimerization interface [polypeptide binding]; other site 169963008179 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963008180 DNA binding site [nucleotide binding] 169963008181 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 169963008182 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 169963008183 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 169963008184 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 169963008185 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 169963008186 putative active site [active] 169963008187 catalytic site [active] 169963008188 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 169963008189 putative active site [active] 169963008190 catalytic site [active] 169963008191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 169963008192 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 169963008193 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 169963008194 Peptidase family M23; Region: Peptidase_M23; pfam01551 169963008195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 169963008196 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 169963008197 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 169963008198 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 169963008199 NlpC/P60 family; Region: NLPC_P60; pfam00877 169963008200 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 169963008201 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 169963008202 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 169963008203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963008204 Walker A/P-loop; other site 169963008205 ATP binding site [chemical binding]; other site 169963008206 Q-loop/lid; other site 169963008207 ABC transporter signature motif; other site 169963008208 Walker B; other site 169963008209 D-loop; other site 169963008210 H-loop/switch region; other site 169963008211 Uncharacterized conserved protein [Function unknown]; Region: COG1284 169963008212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963008213 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 169963008214 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 169963008215 peptide chain release factor 2; Provisional; Region: PRK06746 169963008216 This domain is found in peptide chain release factors; Region: PCRF; smart00937 169963008217 RF-1 domain; Region: RF-1; pfam00472 169963008218 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 169963008219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 169963008220 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 169963008221 helicase superfamily c-terminal domain; Region: HELICc; smart00490 169963008222 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 169963008223 SEC-C motif; Region: SEC-C; pfam02810 169963008224 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 169963008225 30S subunit binding site; other site 169963008226 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 169963008227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963008228 active site 169963008229 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 169963008230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963008231 ATP binding site [chemical binding]; other site 169963008232 putative Mg++ binding site [ion binding]; other site 169963008233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963008234 nucleotide binding region [chemical binding]; other site 169963008235 ATP-binding site [chemical binding]; other site 169963008236 EDD domain protein, DegV family; Region: DegV; TIGR00762 169963008237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 169963008238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963008239 active site 169963008240 phosphorylation site [posttranslational modification] 169963008241 intermolecular recognition site; other site 169963008242 dimerization interface [polypeptide binding]; other site 169963008243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 169963008244 DNA binding residues [nucleotide binding] 169963008245 dimerization interface [polypeptide binding]; other site 169963008246 Uncharacterized conserved protein [Function unknown]; Region: COG1739 169963008247 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 169963008248 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 169963008249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 169963008250 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 169963008251 Transcriptional regulator [Transcription]; Region: LytR; COG1316 169963008252 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 169963008253 Mg++ binding site [ion binding]; other site 169963008254 putative catalytic motif [active] 169963008255 substrate binding site [chemical binding]; other site 169963008256 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 169963008257 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 169963008258 active site 169963008259 octamer interface [polypeptide binding]; other site 169963008260 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 169963008261 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008262 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 169963008263 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 169963008265 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 169963008266 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 169963008267 dimer interface [polypeptide binding]; other site 169963008268 ssDNA binding site [nucleotide binding]; other site 169963008269 tetramer (dimer of dimers) interface [polypeptide binding]; other site 169963008270 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 169963008271 rod shape-determining protein Mbl; Provisional; Region: PRK13928 169963008272 MreB and similar proteins; Region: MreB_like; cd10225 169963008273 nucleotide binding site [chemical binding]; other site 169963008274 Mg binding site [ion binding]; other site 169963008275 putative protofilament interaction site [polypeptide binding]; other site 169963008276 RodZ interaction site [polypeptide binding]; other site 169963008277 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 169963008278 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 169963008279 hinge; other site 169963008280 active site 169963008281 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 169963008282 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 169963008283 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 169963008284 gamma subunit interface [polypeptide binding]; other site 169963008285 epsilon subunit interface [polypeptide binding]; other site 169963008286 LBP interface [polypeptide binding]; other site 169963008287 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 169963008288 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 169963008289 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 169963008290 alpha subunit interaction interface [polypeptide binding]; other site 169963008291 Walker A motif; other site 169963008292 ATP binding site [chemical binding]; other site 169963008293 Walker B motif; other site 169963008294 inhibitor binding site; inhibition site 169963008295 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 169963008296 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 169963008297 core domain interface [polypeptide binding]; other site 169963008298 delta subunit interface [polypeptide binding]; other site 169963008299 epsilon subunit interface [polypeptide binding]; other site 169963008300 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 169963008301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 169963008302 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 169963008303 beta subunit interaction interface [polypeptide binding]; other site 169963008304 Walker A motif; other site 169963008305 ATP binding site [chemical binding]; other site 169963008306 Walker B motif; other site 169963008307 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 169963008308 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 169963008309 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 169963008310 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 169963008311 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 169963008312 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 169963008313 ATP synthase I chain; Region: ATP_synt_I; pfam03899 169963008314 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 169963008315 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 169963008316 active site 169963008317 homodimer interface [polypeptide binding]; other site 169963008318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 169963008319 active site 169963008320 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 169963008321 dimer interface [polypeptide binding]; other site 169963008322 active site 169963008323 glycine-pyridoxal phosphate binding site [chemical binding]; other site 169963008324 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 169963008325 folate binding site [chemical binding]; other site 169963008326 Low molecular weight phosphatase family; Region: LMWPc; cd00115 169963008327 active site 169963008328 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 169963008329 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 169963008330 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 169963008331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963008332 S-adenosylmethionine binding site [chemical binding]; other site 169963008333 peptide chain release factor 1; Validated; Region: prfA; PRK00591 169963008334 This domain is found in peptide chain release factors; Region: PCRF; smart00937 169963008335 RF-1 domain; Region: RF-1; pfam00472 169963008336 thymidine kinase; Provisional; Region: PRK04296 169963008337 homoserine kinase; Provisional; Region: PRK01212 169963008338 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 169963008339 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 169963008340 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 169963008341 homodimer interface [polypeptide binding]; other site 169963008342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963008343 catalytic residue [active] 169963008344 homoserine dehydrogenase; Provisional; Region: PRK06349 169963008345 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 169963008346 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 169963008347 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 169963008348 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 169963008349 Predicted membrane protein [Function unknown]; Region: COG2246 169963008350 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 169963008351 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 169963008352 Ligand binding site; other site 169963008353 Putative Catalytic site; other site 169963008354 DXD motif; other site 169963008355 transcription termination factor Rho; Provisional; Region: rho; PRK09376 169963008356 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 169963008357 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 169963008358 RNA binding site [nucleotide binding]; other site 169963008359 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 169963008360 multimer interface [polypeptide binding]; other site 169963008361 Walker A motif; other site 169963008362 ATP binding site [chemical binding]; other site 169963008363 Walker B motif; other site 169963008364 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 169963008365 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 169963008366 hinge; other site 169963008367 active site 169963008368 Predicted integral membrane protein [Function unknown]; Region: COG0392 169963008369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 169963008370 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 169963008371 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 169963008372 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 169963008373 putative ADP-binding pocket [chemical binding]; other site 169963008374 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 169963008375 intersubunit interface [polypeptide binding]; other site 169963008376 active site 169963008377 zinc binding site [ion binding]; other site 169963008378 Na+ binding site [ion binding]; other site 169963008379 putative lipid kinase; Reviewed; Region: PRK13055 169963008380 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 169963008381 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 169963008382 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 169963008383 amidase catalytic site [active] 169963008384 Zn binding residues [ion binding]; other site 169963008385 substrate binding site [chemical binding]; other site 169963008386 SH3-like domain; Region: SH3_8; pfam13457 169963008387 SH3-like domain; Region: SH3_8; pfam13457 169963008388 SH3-like domain; Region: SH3_8; pfam13457 169963008389 SH3-like domain; Region: SH3_8; pfam13457 169963008390 CTP synthetase; Validated; Region: pyrG; PRK05380 169963008391 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 169963008392 Catalytic site [active] 169963008393 active site 169963008394 UTP binding site [chemical binding]; other site 169963008395 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 169963008396 active site 169963008397 putative oxyanion hole; other site 169963008398 catalytic triad [active] 169963008399 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 169963008400 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 169963008401 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 169963008402 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 169963008403 active site 169963008404 HIGH motif; other site 169963008405 KMSK motif region; other site 169963008406 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 169963008407 tRNA binding surface [nucleotide binding]; other site 169963008408 anticodon binding site; other site 169963008409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 169963008410 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 169963008411 Peptidase family M50; Region: Peptidase_M50; pfam02163 169963008412 active site 169963008413 putative substrate binding region [chemical binding]; other site 169963008414 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 169963008415 active site 1 [active] 169963008416 dimer interface [polypeptide binding]; other site 169963008417 hexamer interface [polypeptide binding]; other site 169963008418 active site 2 [active] 169963008419 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 169963008420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963008421 Zn2+ binding site [ion binding]; other site 169963008422 Mg2+ binding site [ion binding]; other site 169963008423 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 169963008424 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 169963008425 conserved hypothetical protein TIGR01655; Region: yxeA_fam 169963008426 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 169963008427 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 169963008428 peptide binding site [polypeptide binding]; other site 169963008429 Predicted integral membrane protein [Function unknown]; Region: COG5658 169963008430 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 169963008431 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 169963008432 catalytic triad [active] 169963008433 metal binding site [ion binding]; metal-binding site 169963008434 conserved cis-peptide bond; other site 169963008435 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 169963008436 folate binding site [chemical binding]; other site 169963008437 NADP+ binding site [chemical binding]; other site 169963008438 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 169963008439 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 169963008440 putative NAD(P) binding site [chemical binding]; other site 169963008441 dimer interface [polypeptide binding]; other site 169963008442 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 169963008443 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 169963008444 Collagen binding domain; Region: Collagen_bind; pfam05737 169963008445 Collagen binding domain; Region: Collagen_bind; pfam05737 169963008446 Collagen binding domain; Region: Collagen_bind; pfam05737 169963008447 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008448 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008449 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008450 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008451 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008452 Cna protein B-type domain; Region: Cna_B; pfam05738 169963008453 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963008454 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963008455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963008456 active site 169963008457 motif I; other site 169963008458 motif II; other site 169963008459 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963008460 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963008461 Uncharacterized conserved protein [Function unknown]; Region: COG1359 169963008462 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 169963008463 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 169963008464 Walker A/P-loop; other site 169963008465 ATP binding site [chemical binding]; other site 169963008466 Q-loop/lid; other site 169963008467 ABC transporter signature motif; other site 169963008468 Walker B; other site 169963008469 D-loop; other site 169963008470 H-loop/switch region; other site 169963008471 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 169963008472 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 169963008473 FtsX-like permease family; Region: FtsX; pfam02687 169963008474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 169963008475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 169963008476 dimerization interface [polypeptide binding]; other site 169963008477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963008478 dimer interface [polypeptide binding]; other site 169963008479 phosphorylation site [posttranslational modification] 169963008480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963008481 ATP binding site [chemical binding]; other site 169963008482 Mg2+ binding site [ion binding]; other site 169963008483 G-X-G motif; other site 169963008484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963008485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963008486 active site 169963008487 phosphorylation site [posttranslational modification] 169963008488 intermolecular recognition site; other site 169963008489 dimerization interface [polypeptide binding]; other site 169963008490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963008491 DNA binding site [nucleotide binding] 169963008492 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 169963008493 Uncharacterized conserved protein [Function unknown]; Region: COG2427 169963008494 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 169963008495 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 169963008496 catalytic loop [active] 169963008497 iron binding site [ion binding]; other site 169963008498 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 169963008499 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 169963008500 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 169963008501 [4Fe-4S] binding site [ion binding]; other site 169963008502 molybdopterin cofactor binding site; other site 169963008503 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 169963008504 molybdopterin cofactor binding site; other site 169963008505 Uncharacterized conserved protein [Function unknown]; Region: COG1912 169963008506 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 169963008507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963008508 putative substrate translocation pore; other site 169963008509 Protein of unknown function (DUF983); Region: DUF983; cl02211 169963008510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963008511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963008512 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 169963008513 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 169963008514 Walker A motif; other site 169963008515 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963008516 SH3-like domain; Region: SH3_8; pfam13457 169963008517 SH3-like domain; Region: SH3_8; pfam13457 169963008518 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963008519 active site 169963008520 catalytic tetrad [active] 169963008521 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963008522 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963008523 DNA binding residues [nucleotide binding] 169963008524 putative dimer interface [polypeptide binding]; other site 169963008525 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 169963008526 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 169963008527 23S rRNA interface [nucleotide binding]; other site 169963008528 L3 interface [polypeptide binding]; other site 169963008529 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 169963008530 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 169963008531 dimerization interface 3.5A [polypeptide binding]; other site 169963008532 active site 169963008533 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 169963008534 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 169963008535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 169963008536 Walker A/P-loop; other site 169963008537 ATP binding site [chemical binding]; other site 169963008538 Q-loop/lid; other site 169963008539 ABC transporter signature motif; other site 169963008540 Walker B; other site 169963008541 D-loop; other site 169963008542 H-loop/switch region; other site 169963008543 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 169963008544 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 169963008545 Walker A/P-loop; other site 169963008546 ATP binding site [chemical binding]; other site 169963008547 Q-loop/lid; other site 169963008548 ABC transporter signature motif; other site 169963008549 Walker B; other site 169963008550 D-loop; other site 169963008551 H-loop/switch region; other site 169963008552 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 169963008553 MgtC family; Region: MgtC; pfam02308 169963008554 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 169963008555 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 169963008556 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 169963008557 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 169963008558 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 169963008559 alphaNTD homodimer interface [polypeptide binding]; other site 169963008560 alphaNTD - beta interaction site [polypeptide binding]; other site 169963008561 alphaNTD - beta' interaction site [polypeptide binding]; other site 169963008562 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 169963008563 30S ribosomal protein S11; Validated; Region: PRK05309 169963008564 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 169963008565 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 169963008566 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 169963008567 rRNA binding site [nucleotide binding]; other site 169963008568 predicted 30S ribosome binding site; other site 169963008569 adenylate kinase; Reviewed; Region: adk; PRK00279 169963008570 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 169963008571 AMP-binding site [chemical binding]; other site 169963008572 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 169963008573 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 169963008574 SecY translocase; Region: SecY; pfam00344 169963008575 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 169963008576 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 169963008577 23S rRNA binding site [nucleotide binding]; other site 169963008578 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 169963008579 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 169963008580 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 169963008581 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 169963008582 5S rRNA interface [nucleotide binding]; other site 169963008583 L27 interface [polypeptide binding]; other site 169963008584 23S rRNA interface [nucleotide binding]; other site 169963008585 L5 interface [polypeptide binding]; other site 169963008586 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 169963008587 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 169963008588 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 169963008589 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 169963008590 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 169963008591 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 169963008592 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 169963008593 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 169963008594 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 169963008595 RNA binding site [nucleotide binding]; other site 169963008596 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 169963008597 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 169963008598 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 169963008599 23S rRNA interface [nucleotide binding]; other site 169963008600 putative translocon interaction site; other site 169963008601 signal recognition particle (SRP54) interaction site; other site 169963008602 L23 interface [polypeptide binding]; other site 169963008603 trigger factor interaction site; other site 169963008604 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 169963008605 23S rRNA interface [nucleotide binding]; other site 169963008606 5S rRNA interface [nucleotide binding]; other site 169963008607 putative antibiotic binding site [chemical binding]; other site 169963008608 L25 interface [polypeptide binding]; other site 169963008609 L27 interface [polypeptide binding]; other site 169963008610 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 169963008611 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 169963008612 G-X-X-G motif; other site 169963008613 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 169963008614 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 169963008615 putative translocon binding site; other site 169963008616 protein-rRNA interface [nucleotide binding]; other site 169963008617 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 169963008618 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 169963008619 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 169963008620 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 169963008621 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 169963008622 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 169963008623 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 169963008624 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 169963008625 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 169963008626 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 169963008627 putative active site [active] 169963008628 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 169963008629 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 169963008630 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 169963008631 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 169963008632 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 169963008633 Predicted membrane protein [Function unknown]; Region: COG2259 169963008634 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 169963008635 trimer interface [polypeptide binding]; other site 169963008636 Predicted membrane protein [Function unknown]; Region: COG4769 169963008637 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 169963008638 substrate binding pocket [chemical binding]; other site 169963008639 chain length determination region; other site 169963008640 substrate-Mg2+ binding site; other site 169963008641 catalytic residues [active] 169963008642 aspartate-rich region 1; other site 169963008643 active site lid residues [active] 169963008644 aspartate-rich region 2; other site 169963008645 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 169963008646 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 169963008647 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 169963008648 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 169963008649 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963008650 putative active site [active] 169963008651 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 169963008652 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 169963008653 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 169963008654 active site 169963008655 substrate binding pocket [chemical binding]; other site 169963008656 homodimer interaction site [polypeptide binding]; other site 169963008657 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 169963008658 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 169963008659 active site 169963008660 P-loop; other site 169963008661 phosphorylation site [posttranslational modification] 169963008662 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963008663 active site 169963008664 phosphorylation site [posttranslational modification] 169963008665 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963008666 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963008667 PRD domain; Region: PRD; pfam00874 169963008668 PRD domain; Region: PRD; pfam00874 169963008669 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963008670 active site 169963008671 P-loop; other site 169963008672 phosphorylation site [posttranslational modification] 169963008673 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963008674 active site 169963008675 phosphorylation site [posttranslational modification] 169963008676 elongation factor Tu; Reviewed; Region: PRK00049 169963008677 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 169963008678 G1 box; other site 169963008679 GEF interaction site [polypeptide binding]; other site 169963008680 GTP/Mg2+ binding site [chemical binding]; other site 169963008681 Switch I region; other site 169963008682 G2 box; other site 169963008683 G3 box; other site 169963008684 Switch II region; other site 169963008685 G4 box; other site 169963008686 G5 box; other site 169963008687 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 169963008688 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 169963008689 Antibiotic Binding Site [chemical binding]; other site 169963008690 elongation factor G; Reviewed; Region: PRK00007 169963008691 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 169963008692 G1 box; other site 169963008693 putative GEF interaction site [polypeptide binding]; other site 169963008694 GTP/Mg2+ binding site [chemical binding]; other site 169963008695 Switch I region; other site 169963008696 G2 box; other site 169963008697 G3 box; other site 169963008698 Switch II region; other site 169963008699 G4 box; other site 169963008700 G5 box; other site 169963008701 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 169963008702 Elongation Factor G, domain II; Region: EFG_II; pfam14492 169963008703 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 169963008704 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 169963008705 30S ribosomal protein S7; Validated; Region: PRK05302 169963008706 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 169963008707 S17 interaction site [polypeptide binding]; other site 169963008708 S8 interaction site; other site 169963008709 16S rRNA interaction site [nucleotide binding]; other site 169963008710 streptomycin interaction site [chemical binding]; other site 169963008711 23S rRNA interaction site [nucleotide binding]; other site 169963008712 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 169963008713 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 169963008714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 169963008715 Zn2+ binding site [ion binding]; other site 169963008716 Mg2+ binding site [ion binding]; other site 169963008717 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 169963008718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963008719 Coenzyme A binding pocket [chemical binding]; other site 169963008720 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963008721 substrate binding site [chemical binding]; other site 169963008722 hexamer interface [polypeptide binding]; other site 169963008723 metal binding site [ion binding]; metal-binding site 169963008724 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 169963008725 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 169963008726 TPP-binding site [chemical binding]; other site 169963008727 dimer interface [polypeptide binding]; other site 169963008728 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 169963008729 PYR/PP interface [polypeptide binding]; other site 169963008730 dimer interface [polypeptide binding]; other site 169963008731 TPP binding site [chemical binding]; other site 169963008732 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 169963008733 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 169963008734 substrate binding site [chemical binding]; other site 169963008735 hexamer interface [polypeptide binding]; other site 169963008736 metal binding site [ion binding]; metal-binding site 169963008737 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 169963008738 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 169963008739 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 169963008740 putative NAD(P) binding site [chemical binding]; other site 169963008741 catalytic Zn binding site [ion binding]; other site 169963008742 structural Zn binding site [ion binding]; other site 169963008743 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 169963008744 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 169963008745 putative NAD(P) binding site [chemical binding]; other site 169963008746 catalytic Zn binding site [ion binding]; other site 169963008747 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 169963008748 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 169963008749 active site 169963008750 P-loop; other site 169963008751 phosphorylation site [posttranslational modification] 169963008752 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963008753 active site 169963008754 phosphorylation site [posttranslational modification] 169963008755 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963008756 PRD domain; Region: PRD; pfam00874 169963008757 PRD domain; Region: PRD; pfam00874 169963008758 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963008759 active site 169963008760 P-loop; other site 169963008761 phosphorylation site [posttranslational modification] 169963008762 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963008763 active site 169963008764 phosphorylation site [posttranslational modification] 169963008765 Predicted membrane protein [Function unknown]; Region: COG4905 169963008766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 169963008767 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 169963008768 active site 169963008769 Helix-turn-helix domain; Region: HTH_18; pfam12833 169963008770 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 169963008771 Ligand Binding Site [chemical binding]; other site 169963008772 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 169963008773 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 169963008774 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 169963008775 active site 169963008776 DNA binding site [nucleotide binding] 169963008777 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 169963008778 Putative lysophospholipase; Region: Hydrolase_4; cl19140 169963008779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 169963008780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 169963008781 active site 169963008782 phosphorylation site [posttranslational modification] 169963008783 intermolecular recognition site; other site 169963008784 dimerization interface [polypeptide binding]; other site 169963008785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 169963008786 DNA binding site [nucleotide binding] 169963008787 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 169963008788 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 169963008789 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 169963008790 Ligand Binding Site [chemical binding]; other site 169963008791 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 169963008792 GAF domain; Region: GAF_3; pfam13492 169963008793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 169963008794 dimer interface [polypeptide binding]; other site 169963008795 phosphorylation site [posttranslational modification] 169963008796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 169963008797 ATP binding site [chemical binding]; other site 169963008798 Mg2+ binding site [ion binding]; other site 169963008799 G-X-G motif; other site 169963008800 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 169963008801 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 169963008802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963008803 Soluble P-type ATPase [General function prediction only]; Region: COG4087 169963008804 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 169963008805 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963008806 active site 169963008807 P-loop; other site 169963008808 phosphorylation site [posttranslational modification] 169963008809 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963008810 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963008811 methionine cluster; other site 169963008812 active site 169963008813 phosphorylation site [posttranslational modification] 169963008814 metal binding site [ion binding]; metal-binding site 169963008815 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 169963008816 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 169963008817 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 169963008818 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 169963008819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 169963008820 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 169963008821 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 169963008822 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 169963008823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963008824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963008825 autolysin; Reviewed; Region: PRK06347 169963008826 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 169963008827 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008829 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008830 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 169963008831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3870 169963008832 thymidylate kinase; Validated; Region: tmk; PRK00698 169963008833 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 169963008834 TMP-binding site; other site 169963008835 ATP-binding site [chemical binding]; other site 169963008836 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 169963008837 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 169963008838 homodimer interface [polypeptide binding]; other site 169963008839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963008840 catalytic residue [active] 169963008841 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 169963008842 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 169963008843 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 169963008844 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 169963008845 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963008846 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963008847 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963008848 putative active site [active] 169963008849 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 169963008850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963008851 active site 169963008852 motif I; other site 169963008853 motif II; other site 169963008854 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963008855 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 169963008856 active site 169963008857 catalytic tetrad [active] 169963008858 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 169963008859 recombination protein RecR; Reviewed; Region: recR; PRK00076 169963008860 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 169963008861 RecR protein; Region: RecR; pfam02132 169963008862 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 169963008863 putative active site [active] 169963008864 putative metal-binding site [ion binding]; other site 169963008865 tetramer interface [polypeptide binding]; other site 169963008866 hypothetical protein; Validated; Region: PRK00153 169963008867 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 169963008868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 169963008869 Walker A motif; other site 169963008870 ATP binding site [chemical binding]; other site 169963008871 Walker B motif; other site 169963008872 arginine finger; other site 169963008873 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 169963008874 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 169963008875 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 169963008876 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963008877 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 169963008878 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 169963008879 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 169963008880 N- and C-terminal domain interface [polypeptide binding]; other site 169963008881 active site 169963008882 catalytic site [active] 169963008883 metal binding site [ion binding]; metal-binding site 169963008884 carbohydrate binding site [chemical binding]; other site 169963008885 ATP binding site [chemical binding]; other site 169963008886 SH3-like domain; Region: SH3_8; pfam13457 169963008887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 169963008888 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963008889 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 169963008890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963008891 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 169963008892 Walker A/P-loop; other site 169963008893 ATP binding site [chemical binding]; other site 169963008894 Q-loop/lid; other site 169963008895 ABC transporter signature motif; other site 169963008896 Walker B; other site 169963008897 D-loop; other site 169963008898 H-loop/switch region; other site 169963008899 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 169963008900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963008901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963008902 Walker A/P-loop; other site 169963008903 ATP binding site [chemical binding]; other site 169963008904 Q-loop/lid; other site 169963008905 ABC transporter signature motif; other site 169963008906 Walker B; other site 169963008907 D-loop; other site 169963008908 H-loop/switch region; other site 169963008909 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 169963008910 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 169963008911 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 169963008912 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 169963008913 nucleoside/Zn binding site; other site 169963008914 dimer interface [polypeptide binding]; other site 169963008915 catalytic motif [active] 169963008916 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 169963008917 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 169963008918 acyl-activating enzyme (AAE) consensus motif; other site 169963008919 AMP binding site [chemical binding]; other site 169963008920 active site 169963008921 CoA binding site [chemical binding]; other site 169963008922 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 169963008923 active site 169963008924 trimer interface [polypeptide binding]; other site 169963008925 allosteric site; other site 169963008926 active site lid [active] 169963008927 hexamer (dimer of trimers) interface [polypeptide binding]; other site 169963008928 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963008929 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 169963008930 DNA binding residues [nucleotide binding] 169963008931 drug binding residues [chemical binding]; other site 169963008932 dimer interface [polypeptide binding]; other site 169963008933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963008934 Coenzyme A binding pocket [chemical binding]; other site 169963008935 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 169963008936 dimer interface [polypeptide binding]; other site 169963008937 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 169963008938 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 169963008939 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963008940 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 169963008941 putative DNA binding site [nucleotide binding]; other site 169963008942 putative Zn2+ binding site [ion binding]; other site 169963008943 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 169963008944 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 169963008945 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 169963008946 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 169963008947 DNA binding residues [nucleotide binding] 169963008948 putative dimer interface [polypeptide binding]; other site 169963008949 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 169963008950 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 169963008951 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963008952 active site 169963008953 motif I; other site 169963008954 motif II; other site 169963008955 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963008956 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963008957 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963008958 putative active site [active] 169963008959 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 169963008960 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963008961 active site 169963008962 phosphorylation site [posttranslational modification] 169963008963 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 169963008964 active site 169963008965 P-loop; other site 169963008966 phosphorylation site [posttranslational modification] 169963008967 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 169963008968 alpha-mannosidase; Provisional; Region: PRK09819 169963008969 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 169963008970 active site 169963008971 metal binding site [ion binding]; metal-binding site 169963008972 catalytic site [active] 169963008973 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 169963008974 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 169963008975 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 169963008976 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 169963008977 active site 169963008978 homodimer interface [polypeptide binding]; other site 169963008979 catalytic site [active] 169963008980 glycerate kinase; Region: TIGR00045 169963008981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963008982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963008983 DNA binding site [nucleotide binding] 169963008984 domain linker motif; other site 169963008985 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 169963008986 putative dimerization interface [polypeptide binding]; other site 169963008987 putative ligand binding site [chemical binding]; other site 169963008988 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 169963008989 Domain of unknown function DUF21; Region: DUF21; pfam01595 169963008990 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 169963008991 Transporter associated domain; Region: CorC_HlyC; pfam03471 169963008992 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 169963008993 NAD+ binding site [chemical binding]; other site 169963008994 substrate binding site [chemical binding]; other site 169963008995 putative Zn binding site [ion binding]; other site 169963008996 Pathogenicity locus; Region: Cdd1; pfam11731 169963008997 drug efflux system protein MdtG; Provisional; Region: PRK09874 169963008998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963008999 putative substrate translocation pore; other site 169963009000 Variant SH3 domain; Region: SH3_2; pfam07653 169963009001 peptide ligand binding site [polypeptide binding]; other site 169963009002 Variant SH3 domain; Region: SH3_2; pfam07653 169963009003 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 169963009004 active site 169963009005 intersubunit interactions; other site 169963009006 catalytic residue [active] 169963009007 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 169963009008 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 169963009009 ligand binding site [chemical binding]; other site 169963009010 flexible hinge region; other site 169963009011 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 169963009012 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963009013 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963009014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963009015 Walker A/P-loop; other site 169963009016 ATP binding site [chemical binding]; other site 169963009017 Q-loop/lid; other site 169963009018 ABC transporter signature motif; other site 169963009019 Walker B; other site 169963009020 D-loop; other site 169963009021 H-loop/switch region; other site 169963009022 TfoX C-terminal domain; Region: TfoX_C; pfam04994 169963009023 seryl-tRNA synthetase; Provisional; Region: PRK05431 169963009024 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 169963009025 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 169963009026 dimer interface [polypeptide binding]; other site 169963009027 active site 169963009028 motif 1; other site 169963009029 motif 2; other site 169963009030 motif 3; other site 169963009031 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 169963009032 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 169963009033 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 169963009034 Glutamine amidotransferase class-I; Region: GATase; pfam00117 169963009035 glutamine binding [chemical binding]; other site 169963009036 catalytic triad [active] 169963009037 aminodeoxychorismate synthase; Provisional; Region: PRK07508 169963009038 chorismate binding enzyme; Region: Chorismate_bind; cl10555 169963009039 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 169963009040 substrate-cofactor binding pocket; other site 169963009041 pyridoxal 5'-phosphate binding site [chemical binding]; other site 169963009042 catalytic residue [active] 169963009043 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963009044 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963009045 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963009046 Walker A/P-loop; other site 169963009047 ATP binding site [chemical binding]; other site 169963009048 Q-loop/lid; other site 169963009049 ABC transporter signature motif; other site 169963009050 Walker B; other site 169963009051 D-loop; other site 169963009052 H-loop/switch region; other site 169963009053 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 169963009054 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 169963009055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963009056 Walker A/P-loop; other site 169963009057 ATP binding site [chemical binding]; other site 169963009058 Q-loop/lid; other site 169963009059 ABC transporter signature motif; other site 169963009060 Walker B; other site 169963009061 D-loop; other site 169963009062 H-loop/switch region; other site 169963009063 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 169963009064 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 169963009065 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 169963009066 Predicted acyl esterases [General function prediction only]; Region: COG2936 169963009067 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 169963009068 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 169963009069 DNA topoisomerase III; Provisional; Region: PRK07726 169963009070 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 169963009071 active site 169963009072 putative interdomain interaction site [polypeptide binding]; other site 169963009073 putative metal-binding site [ion binding]; other site 169963009074 putative nucleotide binding site [chemical binding]; other site 169963009075 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 169963009076 domain I; other site 169963009077 DNA binding groove [nucleotide binding] 169963009078 phosphate binding site [ion binding]; other site 169963009079 domain II; other site 169963009080 domain III; other site 169963009081 nucleotide binding site [chemical binding]; other site 169963009082 catalytic site [active] 169963009083 domain IV; other site 169963009084 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 169963009085 C-terminal zinc ribbon domain of RNA polymerase intrinsic transcript cleavage subunit; Region: Zn-ribbon; cl02609 169963009086 Zn binding site [ion binding]; other site 169963009087 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 169963009088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 169963009089 ATP binding site [chemical binding]; other site 169963009090 putative Mg++ binding site [ion binding]; other site 169963009091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 169963009092 nucleotide binding region [chemical binding]; other site 169963009093 ATP-binding site [chemical binding]; other site 169963009094 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 169963009095 HRDC domain; Region: HRDC; pfam00570 169963009096 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 169963009097 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 169963009098 active site 169963009099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 169963009100 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 169963009101 putative ADP-ribose binding site [chemical binding]; other site 169963009102 putative active site [active] 169963009103 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 169963009104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963009105 ABC transporter; Region: ABC_tran_2; pfam12848 169963009106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 169963009107 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 169963009108 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963009109 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963009110 active site 169963009111 P-loop; other site 169963009112 phosphorylation site [posttranslational modification] 169963009113 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963009114 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963009115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963009116 nucleotide binding site [chemical binding]; other site 169963009117 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963009118 methionine cluster; other site 169963009119 active site 169963009120 phosphorylation site [posttranslational modification] 169963009121 metal binding site [ion binding]; metal-binding site 169963009122 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963009123 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963009124 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963009125 putative active site [active] 169963009126 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 169963009127 Acyltransferase family; Region: Acyl_transf_3; cl19154 169963009128 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 169963009129 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 169963009130 Walker A/P-loop; other site 169963009131 ATP binding site [chemical binding]; other site 169963009132 Q-loop/lid; other site 169963009133 ABC transporter signature motif; other site 169963009134 Walker B; other site 169963009135 D-loop; other site 169963009136 H-loop/switch region; other site 169963009137 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 169963009138 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 169963009139 ATP-grasp domain; Region: ATP-grasp_4; cl17255 169963009140 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 169963009141 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 169963009142 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 169963009143 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963009144 active site turn [active] 169963009145 phosphorylation site [posttranslational modification] 169963009146 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963009147 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1; Region: PTS_EIIA_1; pfam00358 169963009148 HPr interaction site; other site 169963009149 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963009150 active site 169963009151 phosphorylation site [posttranslational modification] 169963009152 transcriptional antiterminator BglG; Provisional; Region: PRK09772 169963009153 CAT RNA binding domain; Region: CAT_RBD; smart01061 169963009154 PRD domain; Region: PRD; pfam00874 169963009155 PRD domain; Region: PRD; pfam00874 169963009156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 169963009157 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 169963009158 Walker A/P-loop; other site 169963009159 ATP binding site [chemical binding]; other site 169963009160 Q-loop/lid; other site 169963009161 ABC transporter signature motif; other site 169963009162 Walker B; other site 169963009163 D-loop; other site 169963009164 H-loop/switch region; other site 169963009165 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 169963009166 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 169963009167 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 169963009168 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 169963009169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009170 putative substrate translocation pore; other site 169963009171 GTP-binding protein YchF; Reviewed; Region: PRK09601 169963009172 YchF GTPase; Region: YchF; cd01900 169963009173 G1 box; other site 169963009174 GTP/Mg2+ binding site [chemical binding]; other site 169963009175 Switch I region; other site 169963009176 G2 box; other site 169963009177 Switch II region; other site 169963009178 G3 box; other site 169963009179 G4 box; other site 169963009180 G5 box; other site 169963009181 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 169963009182 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 169963009183 methionine cluster; other site 169963009184 active site 169963009185 phosphorylation site [posttranslational modification] 169963009186 metal binding site [ion binding]; metal-binding site 169963009187 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 169963009188 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 169963009189 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 169963009190 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 169963009191 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 169963009192 active site 169963009193 P-loop; other site 169963009194 phosphorylation site [posttranslational modification] 169963009195 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 169963009196 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 169963009197 HTH domain; Region: HTH_11; pfam08279 169963009198 Mga helix-turn-helix domain; Region: Mga; pfam05043 169963009199 PRD domain; Region: PRD; pfam00874 169963009200 PRD domain; Region: PRD; pfam00874 169963009201 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 169963009202 active site 169963009203 P-loop; other site 169963009204 phosphorylation site [posttranslational modification] 169963009205 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963009206 active site 169963009207 phosphorylation site [posttranslational modification] 169963009208 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 169963009209 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 169963009210 tetramer interface [polypeptide binding]; other site 169963009211 heme binding pocket [chemical binding]; other site 169963009212 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 169963009213 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 169963009214 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 169963009215 active site turn [active] 169963009216 phosphorylation site [posttranslational modification] 169963009217 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 169963009218 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 169963009219 HPr interaction site; other site 169963009220 glycerol kinase (GK) interaction site [polypeptide binding]; other site 169963009221 active site 169963009222 phosphorylation site [posttranslational modification] 169963009223 transcriptional antiterminator BglG; Provisional; Region: PRK09772 169963009224 CAT RNA binding domain; Region: CAT_RBD; pfam03123 169963009225 PRD domain; Region: PRD; pfam00874 169963009226 PRD domain; Region: PRD; pfam00874 169963009227 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 169963009228 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 169963009229 ParB-like nuclease domain; Region: ParB; smart00470 169963009230 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 169963009231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 169963009232 P-loop; other site 169963009233 Magnesium ion binding site [ion binding]; other site 169963009234 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 169963009235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 169963009236 non-specific DNA binding site [nucleotide binding]; other site 169963009237 salt bridge; other site 169963009238 sequence-specific DNA binding site [nucleotide binding]; other site 169963009239 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 169963009240 ParB-like nuclease domain; Region: ParBc; pfam02195 169963009241 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 169963009242 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 169963009243 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 169963009244 putative active site [active] 169963009245 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 169963009246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 169963009247 nucleotide binding site [chemical binding]; other site 169963009248 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 169963009249 active site 169963009250 phosphorylation site [posttranslational modification] 169963009251 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 169963009252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963009253 motif II; other site 169963009254 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 169963009255 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 169963009256 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 169963009257 active site 169963009258 P-loop; other site 169963009259 phosphorylation site [posttranslational modification] 169963009260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963009261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963009262 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963009263 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 169963009264 putative active site cavity [active] 169963009265 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 169963009266 Methyltransferase domain; Region: Methyltransf_31; pfam13847 169963009267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 169963009268 S-adenosylmethionine binding site [chemical binding]; other site 169963009269 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 169963009270 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 169963009271 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 169963009272 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 169963009273 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 169963009274 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 169963009275 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 169963009276 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 169963009277 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 169963009278 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 169963009279 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 169963009280 trmE is a tRNA modification GTPase; Region: trmE; cd04164 169963009281 G1 box; other site 169963009282 GTP/Mg2+ binding site [chemical binding]; other site 169963009283 Switch I region; other site 169963009284 G2 box; other site 169963009285 Switch II region; other site 169963009286 G3 box; other site 169963009287 G4 box; other site 169963009288 G5 box; other site 169963009289 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 169963009290 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 169963009291 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 169963009292 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 169963009293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 169963009294 short chain dehydrogenase; Provisional; Region: PRK12937 169963009295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 169963009296 NAD(P) binding site [chemical binding]; other site 169963009297 active site 169963009298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009299 D-galactonate transporter; Region: 2A0114; TIGR00893 169963009300 putative substrate translocation pore; other site 169963009301 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 169963009302 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 169963009303 metal binding site [ion binding]; metal-binding site 169963009304 dimer interface [polypeptide binding]; other site 169963009305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009306 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963009307 putative substrate translocation pore; other site 169963009308 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 169963009309 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 169963009310 metal binding site [ion binding]; metal-binding site 169963009311 dimer interface [polypeptide binding]; other site 169963009312 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 169963009313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 169963009314 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 169963009315 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 169963009316 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cd00116 169963009317 Leucine-rich repeats; other site 169963009318 Substrate binding site [chemical binding]; other site 169963009319 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963009320 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963009321 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963009322 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 169963009323 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 169963009324 Uncharacterized conserved protein [Function unknown]; Region: COG4198 169963009325 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 169963009326 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 169963009327 putative ligand binding site [chemical binding]; other site 169963009328 putative NAD binding site [chemical binding]; other site 169963009329 putative catalytic site [active] 169963009330 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 169963009331 L-serine binding site [chemical binding]; other site 169963009332 ACT domain interface; other site 169963009333 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 169963009334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 169963009335 catalytic residue [active] 169963009336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963009338 putative substrate translocation pore; other site 169963009339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 169963009340 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 169963009341 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 169963009342 dimer interface [polypeptide binding]; other site 169963009343 FMN binding site [chemical binding]; other site 169963009344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 169963009345 catalytic residues [active] 169963009346 beta-phosphoglucomutase; Region: bPGM; TIGR01990 169963009347 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 169963009348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 169963009349 motif II; other site 169963009350 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 169963009351 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 169963009352 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 169963009353 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 169963009354 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 169963009355 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 169963009356 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 169963009357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 169963009358 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 169963009359 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 169963009360 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 169963009361 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 169963009362 putative NAD(P) binding site [chemical binding]; other site 169963009363 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 169963009364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963009365 dimer interface [polypeptide binding]; other site 169963009366 conserved gate region; other site 169963009367 putative PBP binding loops; other site 169963009368 ABC-ATPase subunit interface; other site 169963009369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 169963009370 dimer interface [polypeptide binding]; other site 169963009371 conserved gate region; other site 169963009372 putative PBP binding loops; other site 169963009373 ABC-ATPase subunit interface; other site 169963009374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 169963009375 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 169963009376 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 169963009377 active site 169963009378 catalytic site [active] 169963009379 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 169963009380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 169963009381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 169963009382 DNA binding site [nucleotide binding] 169963009383 domain linker motif; other site 169963009384 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 169963009385 putative dimerization interface [polypeptide binding]; other site 169963009386 putative ligand binding site [chemical binding]; other site 169963009387 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 169963009388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 169963009389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 169963009390 Coenzyme A binding pocket [chemical binding]; other site 169963009391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 169963009392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009393 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963009394 putative substrate translocation pore; other site 169963009395 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 169963009396 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 169963009397 intersubunit interface [polypeptide binding]; other site 169963009398 active site 169963009399 Zn2+ binding site [ion binding]; other site 169963009400 L-rhamnose isomerase; Provisional; Region: PRK01076 169963009401 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 169963009402 N- and C-terminal domain interface [polypeptide binding]; other site 169963009403 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 169963009404 active site 169963009405 putative catalytic site [active] 169963009406 metal binding site [ion binding]; metal-binding site 169963009407 ATP binding site [chemical binding]; other site 169963009408 carbohydrate binding site [chemical binding]; other site 169963009409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 169963009410 putative substrate translocation pore; other site 169963009411 Major Facilitator Superfamily; Region: MFS_1; pfam07690 169963009412 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 169963009413 Helix-turn-helix domain; Region: HTH_18; pfam12833 169963009414 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 169963009415 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 169963009416 Jag N-terminus; Region: Jag_N; pfam14804 169963009417 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 169963009418 G-X-X-G motif; other site 169963009419 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 169963009420 RxxxH motif; other site 169963009421 OxaA-like protein precursor; Provisional; Region: PRK02463 169963009422 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 169963009423 ribonuclease P; Reviewed; Region: rnpA; PRK00499 169963009424 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399