-- dump date   	20140619_132554
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
393126000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
393126000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
393126000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126000004	Walker A motif; other site
393126000005	ATP binding site [chemical binding]; other site
393126000006	Walker B motif; other site
393126000007	arginine finger; other site
393126000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
393126000009	DnaA box-binding interface [nucleotide binding]; other site
393126000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
393126000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
393126000012	putative DNA binding surface [nucleotide binding]; other site
393126000013	dimer interface [polypeptide binding]; other site
393126000014	beta-clamp/clamp loader binding surface; other site
393126000015	beta-clamp/translesion DNA polymerase binding surface; other site
393126000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393126000017	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
393126000018	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
393126000019	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
393126000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
393126000021	Walker A/P-loop; other site
393126000022	ATP binding site [chemical binding]; other site
393126000023	Q-loop/lid; other site
393126000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126000025	ABC transporter signature motif; other site
393126000026	Walker B; other site
393126000027	D-loop; other site
393126000028	H-loop/switch region; other site
393126000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
393126000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126000031	Mg2+ binding site [ion binding]; other site
393126000032	G-X-G motif; other site
393126000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
393126000034	anchoring element; other site
393126000035	dimer interface [polypeptide binding]; other site
393126000036	ATP binding site [chemical binding]; other site
393126000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
393126000038	active site
393126000039	putative metal-binding site [ion binding]; other site
393126000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
393126000041	DNA gyrase subunit A; Validated; Region: PRK05560
393126000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
393126000043	CAP-like domain; other site
393126000044	active site
393126000045	primary dimer interface [polypeptide binding]; other site
393126000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126000051	cardiolipin synthetase; Reviewed; Region: PRK12452
393126000052	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
393126000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
393126000054	putative active site [active]
393126000055	catalytic site [active]
393126000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
393126000057	putative active site [active]
393126000058	catalytic site [active]
393126000059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393126000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126000061	Coenzyme A binding pocket [chemical binding]; other site
393126000062	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
393126000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393126000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393126000065	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
393126000066	diphosphomevalonate decarboxylase; Region: PLN02407
393126000067	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
393126000068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393126000069	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
393126000070	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
393126000071	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
393126000072	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
393126000073	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
393126000074	D-pathway; other site
393126000075	Putative ubiquinol binding site [chemical binding]; other site
393126000076	Low-spin heme (heme b) binding site [chemical binding]; other site
393126000077	Putative water exit pathway; other site
393126000078	Binuclear center (heme o3/CuB) [ion binding]; other site
393126000079	K-pathway; other site
393126000080	Putative proton exit pathway; other site
393126000081	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
393126000082	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
393126000083	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
393126000084	putative active site [active]
393126000085	putative metal binding site [ion binding]; other site
393126000086	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
393126000087	beta-galactosidase; Region: BGL; TIGR03356
393126000088	Bacterial SH3 domain; Region: SH3_3; pfam08239
393126000089	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
393126000090	putative active site [active]
393126000091	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126000092	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126000093	DNA-binding site [nucleotide binding]; DNA binding site
393126000094	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393126000095	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126000096	active site
393126000097	active pocket/dimerization site; other site
393126000098	phosphorylation site [posttranslational modification]
393126000099	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393126000100	active site
393126000101	phosphorylation site [posttranslational modification]
393126000102	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
393126000103	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
393126000104	hypothetical protein; Provisional; Region: PRK02947
393126000105	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126000106	putative active site [active]
393126000107	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
393126000108	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
393126000109	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126000110	active site turn [active]
393126000111	phosphorylation site [posttranslational modification]
393126000112	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126000113	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393126000114	HPr interaction site; other site
393126000115	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126000116	active site
393126000117	phosphorylation site [posttranslational modification]
393126000118	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
393126000119	putative dimer interface [polypeptide binding]; other site
393126000120	catalytic triad [active]
393126000121	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126000122	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000123	active site
393126000124	motif I; other site
393126000125	motif II; other site
393126000126	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000127	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126000128	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126000129	DNA binding site [nucleotide binding]
393126000130	domain linker motif; other site
393126000131	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
393126000132	dimerization interface [polypeptide binding]; other site
393126000133	putative ligand binding site [chemical binding]; other site
393126000134	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126000135	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126000136	nucleotide binding site [chemical binding]; other site
393126000137	Butyrate kinase [Energy production and conversion]; Region: COG3426
393126000138	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
393126000139	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
393126000140	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126000141	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126000142	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393126000143	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393126000144	dimer interface [polypeptide binding]; other site
393126000145	active site
393126000146	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393126000147	dimer interface [polypeptide binding]; other site
393126000148	active site
393126000149	putrescine carbamoyltransferase; Provisional; Region: PRK02255
393126000150	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393126000151	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393126000152	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
393126000153	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
393126000154	agmatine deiminase; Provisional; Region: PRK13551
393126000155	agmatine deiminase; Region: agmatine_aguA; TIGR03380
393126000156	carbamate kinase; Reviewed; Region: PRK12686
393126000157	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
393126000158	putative substrate binding site [chemical binding]; other site
393126000159	nucleotide binding site [chemical binding]; other site
393126000160	nucleotide binding site [chemical binding]; other site
393126000161	homodimer interface [polypeptide binding]; other site
393126000162	agmatine deiminase; Provisional; Region: PRK13551
393126000163	agmatine deiminase; Region: agmatine_aguA; TIGR03380
393126000164	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126000165	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126000166	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126000167	putative active site [active]
393126000168	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
393126000169	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393126000170	arginine deiminase; Provisional; Region: PRK01388
393126000171	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
393126000172	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393126000173	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393126000174	dimer interface [polypeptide binding]; other site
393126000175	ssDNA binding site [nucleotide binding]; other site
393126000176	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126000177	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
393126000178	Predicted membrane protein [Function unknown]; Region: COG3212
393126000179	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393126000180	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393126000181	putative accessory gene regulator protein; Provisional; Region: PRK01100
393126000182	Staphylococcal AgrD protein; Region: AgrD; cl05477
393126000183	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
393126000184	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126000185	ATP binding site [chemical binding]; other site
393126000186	Mg2+ binding site [ion binding]; other site
393126000187	G-X-G motif; other site
393126000188	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
393126000189	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126000190	active site
393126000191	phosphorylation site [posttranslational modification]
393126000192	intermolecular recognition site; other site
393126000193	LytTr DNA-binding domain; Region: LytTR; pfam04397
393126000194	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
393126000195	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
393126000196	DHH family; Region: DHH; pfam01368
393126000197	DHHA1 domain; Region: DHHA1; pfam02272
393126000198	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
393126000199	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
393126000200	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
393126000201	replicative DNA helicase; Provisional; Region: PRK05748
393126000202	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
393126000203	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
393126000204	Walker A motif; other site
393126000205	ATP binding site [chemical binding]; other site
393126000206	Walker B motif; other site
393126000207	DNA binding loops [nucleotide binding]
393126000208	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
393126000209	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
393126000210	GDP-binding site [chemical binding]; other site
393126000211	ACT binding site; other site
393126000212	IMP binding site; other site
393126000213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
393126000214	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393126000215	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
393126000216	Predicted membrane protein [Function unknown]; Region: COG1511
393126000217	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
393126000218	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
393126000219	Uncharacterized small protein [Function unknown]; Region: COG5417
393126000220	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
393126000221	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
393126000222	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
393126000223	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
393126000224	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393126000225	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393126000226	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
393126000227	Uncharacterized conserved protein [Function unknown]; Region: COG5444
393126000228	ADP-ribosyltransferase exoenzyme; Region: ADPrib_exo_Tox; pfam03496
393126000229	active site
393126000230	conformational flexibility of ligand binding pocket; other site
393126000231	ADP-ribosylating toxin turn-turn motif; other site
393126000232	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
393126000233	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
393126000234	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
393126000235	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
393126000236	tetramer interface [polypeptide binding]; other site
393126000237	active site
393126000238	Mg2+/Mn2+ binding site [ion binding]; other site
393126000239	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
393126000240	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
393126000241	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393126000242	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393126000243	DNA binding site [nucleotide binding]
393126000244	active site
393126000245	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393126000246	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126000247	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393126000248	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
393126000249	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
393126000250	putative ligand binding site [chemical binding]; other site
393126000251	putative NAD binding site [chemical binding]; other site
393126000252	catalytic site [active]
393126000253	LXG domain of WXG superfamily; Region: LXG; pfam04740
393126000254	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126000255	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126000256	DNA binding residues [nucleotide binding]
393126000257	putative dimer interface [polypeptide binding]; other site
393126000258	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126000259	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126000260	active site
393126000261	catalytic tetrad [active]
393126000262	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000263	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126000264	ATP synthase subunit C; Region: ATP-synt_C; cl00466
393126000265	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
393126000266	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
393126000267	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393126000268	Walker A motif; other site
393126000269	ATP binding site [chemical binding]; other site
393126000270	Walker B motif; other site
393126000271	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393126000272	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
393126000273	core domain interface [polypeptide binding]; other site
393126000274	delta subunit interface [polypeptide binding]; other site
393126000275	epsilon subunit interface [polypeptide binding]; other site
393126000276	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
393126000277	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393126000278	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
393126000279	alpha subunit interaction interface [polypeptide binding]; other site
393126000280	Walker A motif; other site
393126000281	ATP binding site [chemical binding]; other site
393126000282	Walker B motif; other site
393126000283	inhibitor binding site; inhibition site
393126000284	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393126000285	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823
393126000286	gamma subunit interface [polypeptide binding]; other site
393126000287	epsilon subunit interface [polypeptide binding]; other site
393126000288	LBP interface [polypeptide binding]; other site
393126000289	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000290	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
393126000291	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126000292	active pocket/dimerization site; other site
393126000293	active site
393126000294	phosphorylation site [posttranslational modification]
393126000295	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393126000296	active site
393126000297	phosphorylation site [posttranslational modification]
393126000298	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
393126000299	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
393126000300	Domain of unknown function (DUF956); Region: DUF956; pfam06115
393126000301	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
393126000302	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126000303	dimerization interface [polypeptide binding]; other site
393126000304	putative DNA binding site [nucleotide binding]; other site
393126000305	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393126000306	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
393126000307	dimer interface [polypeptide binding]; other site
393126000308	FMN binding site [chemical binding]; other site
393126000309	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
393126000310	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
393126000311	active site
393126000312	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
393126000313	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
393126000314	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393126000315	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393126000316	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126000317	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126000318	nucleotide binding site [chemical binding]; other site
393126000319	butyrate kinase; Region: butyr_kinase; TIGR02707
393126000320	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126000321	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126000322	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393126000323	Walker A/P-loop; other site
393126000324	ATP binding site [chemical binding]; other site
393126000325	Q-loop/lid; other site
393126000326	ABC transporter signature motif; other site
393126000327	Walker B; other site
393126000328	D-loop; other site
393126000329	H-loop/switch region; other site
393126000330	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126000331	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126000332	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393126000333	Walker A/P-loop; other site
393126000334	ATP binding site [chemical binding]; other site
393126000335	Q-loop/lid; other site
393126000336	ABC transporter signature motif; other site
393126000337	Walker B; other site
393126000338	D-loop; other site
393126000339	H-loop/switch region; other site
393126000340	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
393126000341	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126000342	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126000343	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126000344	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
393126000345	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
393126000346	substrate binding pocket [chemical binding]; other site
393126000347	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393126000348	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000349	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393126000350	ligand binding site [chemical binding]; other site
393126000351	flexible hinge region; other site
393126000352	Domain of unknown function (DUF955); Region: DUF955; pfam06114
393126000353	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126000354	non-specific DNA binding site [nucleotide binding]; other site
393126000355	salt bridge; other site
393126000356	sequence-specific DNA binding site [nucleotide binding]; other site
393126000357	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
393126000358	Predicted secreted protein [Function unknown]; Region: COG5437
393126000359	Phage-related protein [Function unknown]; Region: COG5412
393126000360	Phage tail protein; Region: Sipho_tail; pfam05709
393126000361	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
393126000362	Predicted membrane protein [Function unknown]; Region: COG1511
393126000363	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
393126000364	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
393126000365	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
393126000366	active site
393126000367	metal binding site [ion binding]; metal-binding site
393126000368	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
393126000369	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
393126000370	putative active site [active]
393126000371	putative metal binding site [ion binding]; other site
393126000372	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
393126000373	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393126000374	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
393126000375	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
393126000376	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
393126000377	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
393126000378	active site
393126000379	Uncharacterized conserved protein [Function unknown]; Region: COG3592
393126000380	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126000381	Coenzyme A binding pocket [chemical binding]; other site
393126000382	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
393126000383	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
393126000384	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393126000385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000386	dimer interface [polypeptide binding]; other site
393126000387	conserved gate region; other site
393126000388	putative PBP binding loops; other site
393126000389	ABC-ATPase subunit interface; other site
393126000390	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393126000391	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
393126000392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000393	dimer interface [polypeptide binding]; other site
393126000394	conserved gate region; other site
393126000395	putative PBP binding loops; other site
393126000396	ABC-ATPase subunit interface; other site
393126000397	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
393126000398	LXG domain of WXG superfamily; Region: LXG; pfam04740
393126000399	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393126000400	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393126000401	peptide binding site [polypeptide binding]; other site
393126000402	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393126000403	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
393126000404	metal binding site [ion binding]; metal-binding site
393126000405	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
393126000406	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393126000407	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393126000408	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126000409	ABC-ATPase subunit  interface; other site
393126000410	dimer interface [polypeptide binding]; other site
393126000411	putative PBP binding regions; other site
393126000412	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000413	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126000414	ligand binding site [chemical binding]; other site
393126000415	flexible hinge region; other site
393126000416	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
393126000417	DEAD_2; Region: DEAD_2; pfam06733
393126000418	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
393126000419	sugar phosphate phosphatase; Provisional; Region: PRK10513
393126000420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000421	active site
393126000422	motif I; other site
393126000423	motif II; other site
393126000424	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000425	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393126000426	Collagen binding domain; Region: Collagen_bind; pfam05737
393126000427	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000428	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000429	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000430	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000431	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393126000432	Collagen binding domain; Region: Collagen_bind; pfam05737
393126000433	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000434	Cna protein B-type domain; Region: Cna_B; pfam05738
393126000435	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126000436	DNA polymerase III subunit delta'; Validated; Region: PRK08058
393126000437	DNA polymerase III subunit delta'; Validated; Region: PRK08485
393126000438	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
393126000439	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
393126000440	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
393126000441	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126000442	S-adenosylmethionine binding site [chemical binding]; other site
393126000443	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
393126000444	GIY-YIG motif/motif A; other site
393126000445	putative active site [active]
393126000446	putative metal binding site [ion binding]; other site
393126000447	Predicted methyltransferases [General function prediction only]; Region: COG0313
393126000448	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
393126000449	putative SAM binding site [chemical binding]; other site
393126000450	putative homodimer interface [polypeptide binding]; other site
393126000451	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
393126000452	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
393126000453	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393126000454	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393126000455	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393126000456	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
393126000457	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000458	Leucine rich repeat; Region: LRR_8; pfam13855
393126000459	LRR adjacent; Region: LRR_adjacent; pfam08191
393126000460	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126000461	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126000462	HTH-like domain; Region: HTH_21; pfam13276
393126000463	Integrase core domain; Region: rve; pfam00665
393126000464	Integrase core domain; Region: rve_3; cl15866
393126000465	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
393126000466	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126000467	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126000468	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393126000469	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
393126000470	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
393126000471	active site
393126000472	HIGH motif; other site
393126000473	KMSKS motif; other site
393126000474	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
393126000475	tRNA binding surface [nucleotide binding]; other site
393126000476	anticodon binding site; other site
393126000477	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
393126000478	dimer interface [polypeptide binding]; other site
393126000479	putative tRNA-binding site [nucleotide binding]; other site
393126000480	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
393126000481	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126000482	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126000483	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
393126000484	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393126000485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000486	dimer interface [polypeptide binding]; other site
393126000487	conserved gate region; other site
393126000488	putative PBP binding loops; other site
393126000489	ABC-ATPase subunit interface; other site
393126000490	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126000491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000492	dimer interface [polypeptide binding]; other site
393126000493	conserved gate region; other site
393126000494	putative PBP binding loops; other site
393126000495	ABC-ATPase subunit interface; other site
393126000496	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393126000497	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126000498	alpha-glucosidase; Provisional; Region: PRK10426
393126000499	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393126000500	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
393126000501	active site
393126000502	catalytic site [active]
393126000503	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393126000504	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393126000505	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
393126000506	trimer interface [polypeptide binding]; other site
393126000507	active site
393126000508	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
393126000509	catalytic site [active]
393126000510	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393126000511	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393126000512	Ca binding site [ion binding]; other site
393126000513	active site
393126000514	catalytic site [active]
393126000515	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
393126000516	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
393126000517	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
393126000518	active site
393126000519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
393126000520	Domain of unknown function (DUF348); Region: DUF348; pfam03990
393126000521	Domain of unknown function (DUF348); Region: DUF348; pfam03990
393126000522	G5 domain; Region: G5; pfam07501
393126000523	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
393126000524	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
393126000525	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
393126000526	putative active site [active]
393126000527	putative metal binding site [ion binding]; other site
393126000528	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
393126000529	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
393126000530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126000531	S-adenosylmethionine binding site [chemical binding]; other site
393126000532	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
393126000533	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
393126000534	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393126000535	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
393126000536	putative active site [active]
393126000537	YdjC motif; other site
393126000538	Mg binding site [ion binding]; other site
393126000539	putative homodimer interface [polypeptide binding]; other site
393126000540	pur operon repressor; Provisional; Region: PRK09213
393126000541	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
393126000542	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126000543	active site
393126000544	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
393126000545	HlyD family secretion protein; Region: HlyD_3; pfam13437
393126000546	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126000547	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126000548	Walker A/P-loop; other site
393126000549	ATP binding site [chemical binding]; other site
393126000550	Q-loop/lid; other site
393126000551	ABC transporter signature motif; other site
393126000552	Walker B; other site
393126000553	D-loop; other site
393126000554	H-loop/switch region; other site
393126000555	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126000556	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393126000557	FtsX-like permease family; Region: FtsX; pfam02687
393126000558	regulatory protein SpoVG; Reviewed; Region: PRK13259
393126000559	regulatory protein SpoVG; Reviewed; Region: PRK13259
393126000560	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
393126000561	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
393126000562	Substrate binding site; other site
393126000563	Mg++ binding site; other site
393126000564	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
393126000565	active site
393126000566	substrate binding site [chemical binding]; other site
393126000567	CoA binding site [chemical binding]; other site
393126000568	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
393126000569	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
393126000570	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126000571	active site
393126000572	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000573	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126000574	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126000575	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
393126000576	active site
393126000577	catalytic site [active]
393126000578	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
393126000579	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
393126000580	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
393126000581	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393126000582	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
393126000583	active site
393126000584	Zn binding site [ion binding]; other site
393126000585	ActA Protein; Region: ActA; pfam05058
393126000586	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
393126000587	Zn binding site [ion binding]; other site
393126000588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
393126000589	hypothetical protein; Provisional; Region: PRK01119
393126000590	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
393126000591	A new structural DNA glycosylase; Region: AlkD_like; cd06561
393126000592	active site
393126000593	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
393126000594	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393126000595	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126000596	NAD binding site [chemical binding]; other site
393126000597	dimer interface [polypeptide binding]; other site
393126000598	substrate binding site [chemical binding]; other site
393126000599	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
393126000600	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
393126000601	5S rRNA interface [nucleotide binding]; other site
393126000602	CTC domain interface [polypeptide binding]; other site
393126000603	L16 interface [polypeptide binding]; other site
393126000604	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126000605	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126000606	Coenzyme A binding pocket [chemical binding]; other site
393126000607	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
393126000608	putative active site [active]
393126000609	catalytic residue [active]
393126000610	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
393126000611	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
393126000612	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126000613	ATP binding site [chemical binding]; other site
393126000614	putative Mg++ binding site [ion binding]; other site
393126000615	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126000616	nucleotide binding region [chemical binding]; other site
393126000617	ATP-binding site [chemical binding]; other site
393126000618	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
393126000619	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393126000620	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393126000621	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126000622	RNA binding surface [nucleotide binding]; other site
393126000623	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
393126000624	Septum formation initiator; Region: DivIC; pfam04977
393126000625	hypothetical protein; Provisional; Region: PRK08582
393126000626	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393126000627	RNA binding site [nucleotide binding]; other site
393126000628	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
393126000629	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
393126000630	Ligand Binding Site [chemical binding]; other site
393126000631	TilS substrate C-terminal domain; Region: TilS_C; smart00977
393126000632	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
393126000633	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126000634	active site
393126000635	FtsH Extracellular; Region: FtsH_ext; pfam06480
393126000636	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
393126000637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126000638	Walker A motif; other site
393126000639	ATP binding site [chemical binding]; other site
393126000640	Walker B motif; other site
393126000641	arginine finger; other site
393126000642	Peptidase family M41; Region: Peptidase_M41; pfam01434
393126000643	pantothenate kinase; Reviewed; Region: PRK13318
393126000644	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
393126000645	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
393126000646	dimerization interface [polypeptide binding]; other site
393126000647	domain crossover interface; other site
393126000648	redox-dependent activation switch; other site
393126000649	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
393126000650	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
393126000651	dimer interface [polypeptide binding]; other site
393126000652	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126000653	catalytic residue [active]
393126000654	dihydropteroate synthase; Region: DHPS; TIGR01496
393126000655	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
393126000656	substrate binding pocket [chemical binding]; other site
393126000657	dimer interface [polypeptide binding]; other site
393126000658	inhibitor binding site; inhibition site
393126000659	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
393126000660	homooctamer interface [polypeptide binding]; other site
393126000661	active site
393126000662	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
393126000663	catalytic center binding site [active]
393126000664	ATP binding site [chemical binding]; other site
393126000665	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
393126000666	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
393126000667	FMN binding site [chemical binding]; other site
393126000668	active site
393126000669	catalytic residues [active]
393126000670	substrate binding site [chemical binding]; other site
393126000671	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
393126000672	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
393126000673	dimer interface [polypeptide binding]; other site
393126000674	putative anticodon binding site; other site
393126000675	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
393126000676	motif 1; other site
393126000677	active site
393126000678	motif 2; other site
393126000679	motif 3; other site
393126000680	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
393126000681	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
393126000682	UvrB/uvrC motif; Region: UVR; pfam02151
393126000683	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
393126000684	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
393126000685	ADP binding site [chemical binding]; other site
393126000686	phosphagen binding site; other site
393126000687	substrate specificity loop; other site
393126000688	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
393126000689	Clp amino terminal domain; Region: Clp_N; pfam02861
393126000690	Clp amino terminal domain; Region: Clp_N; pfam02861
393126000691	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126000692	Walker A motif; other site
393126000693	ATP binding site [chemical binding]; other site
393126000694	Walker B motif; other site
393126000695	arginine finger; other site
393126000696	UvrB/uvrC motif; Region: UVR; pfam02151
393126000697	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126000698	Walker A motif; other site
393126000699	ATP binding site [chemical binding]; other site
393126000700	Walker B motif; other site
393126000701	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393126000702	DNA repair protein RadA; Provisional; Region: PRK11823
393126000703	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
393126000704	Walker A motif/ATP binding site; other site
393126000705	ATP binding site [chemical binding]; other site
393126000706	Walker B motif; other site
393126000707	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
393126000708	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
393126000709	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
393126000710	putative active site [active]
393126000711	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
393126000712	substrate binding site; other site
393126000713	dimer interface; other site
393126000714	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
393126000715	homotrimer interaction site [polypeptide binding]; other site
393126000716	zinc binding site [ion binding]; other site
393126000717	CDP-binding sites; other site
393126000718	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
393126000719	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
393126000720	HIGH motif; other site
393126000721	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
393126000722	active site
393126000723	KMSKS motif; other site
393126000724	serine O-acetyltransferase; Region: cysE; TIGR01172
393126000725	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
393126000726	trimer interface [polypeptide binding]; other site
393126000727	active site
393126000728	substrate binding site [chemical binding]; other site
393126000729	CoA binding site [chemical binding]; other site
393126000730	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
393126000731	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
393126000732	active site
393126000733	HIGH motif; other site
393126000734	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
393126000735	KMSKS motif; other site
393126000736	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
393126000737	tRNA binding surface [nucleotide binding]; other site
393126000738	anticodon binding site; other site
393126000739	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
393126000740	active site
393126000741	metal binding site [ion binding]; metal-binding site
393126000742	dimerization interface [polypeptide binding]; other site
393126000743	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
393126000744	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
393126000745	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
393126000746	RNA polymerase factor sigma-70; Validated; Region: PRK08295
393126000747	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393126000748	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
393126000749	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
393126000750	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
393126000751	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
393126000752	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
393126000753	putative homodimer interface [polypeptide binding]; other site
393126000754	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
393126000755	heterodimer interface [polypeptide binding]; other site
393126000756	homodimer interface [polypeptide binding]; other site
393126000757	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
393126000758	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
393126000759	23S rRNA interface [nucleotide binding]; other site
393126000760	L7/L12 interface [polypeptide binding]; other site
393126000761	putative thiostrepton binding site; other site
393126000762	L25 interface [polypeptide binding]; other site
393126000763	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
393126000764	mRNA/rRNA interface [nucleotide binding]; other site
393126000765	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
393126000766	23S rRNA interface [nucleotide binding]; other site
393126000767	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
393126000768	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
393126000769	core dimer interface [polypeptide binding]; other site
393126000770	peripheral dimer interface [polypeptide binding]; other site
393126000771	L10 interface [polypeptide binding]; other site
393126000772	L11 interface [polypeptide binding]; other site
393126000773	putative EF-Tu interaction site [polypeptide binding]; other site
393126000774	putative EF-G interaction site [polypeptide binding]; other site
393126000775	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
393126000776	Penicillinase repressor; Region: Pencillinase_R; pfam03965
393126000777	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
393126000778	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
393126000779	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
393126000780	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393126000781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126000782	S-adenosylmethionine binding site [chemical binding]; other site
393126000783	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
393126000784	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
393126000785	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393126000786	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393126000787	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
393126000788	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393126000789	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
393126000790	RPB10 interaction site [polypeptide binding]; other site
393126000791	RPB1 interaction site [polypeptide binding]; other site
393126000792	RPB11 interaction site [polypeptide binding]; other site
393126000793	RPB3 interaction site [polypeptide binding]; other site
393126000794	RPB12 interaction site [polypeptide binding]; other site
393126000795	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
393126000796	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
393126000797	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
393126000798	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
393126000799	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
393126000800	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
393126000801	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
393126000802	G-loop; other site
393126000803	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
393126000804	DNA binding site [nucleotide binding]
393126000805	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
393126000806	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
393126000807	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000808	active site
393126000809	motif I; other site
393126000810	motif II; other site
393126000811	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126000812	beta-galactosidase; Region: BGL; TIGR03356
393126000813	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126000814	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126000815	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000816	Substrate binding site [chemical binding]; other site
393126000817	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000818	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000819	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000820	LRR adjacent; Region: LRR_adjacent; pfam08191
393126000821	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126000822	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126000823	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126000824	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126000825	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126000826	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000827	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000828	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000829	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000830	LRR adjacent; Region: LRR_adjacent; pfam08191
393126000831	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126000832	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126000833	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126000834	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000835	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000836	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000837	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000838	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126000839	LRR adjacent; Region: LRR_adjacent; pfam08191
393126000840	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126000841	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126000842	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
393126000843	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
393126000844	metal binding site [ion binding]; metal-binding site
393126000845	dimer interface [polypeptide binding]; other site
393126000846	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126000847	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126000848	putative Zn2+ binding site [ion binding]; other site
393126000849	putative DNA binding site [nucleotide binding]; other site
393126000850	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393126000851	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126000852	Zn binding site [ion binding]; other site
393126000853	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393126000854	Zn binding site [ion binding]; other site
393126000855	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126000856	catalytic core [active]
393126000857	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393126000858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000859	dimer interface [polypeptide binding]; other site
393126000860	conserved gate region; other site
393126000861	putative PBP binding loops; other site
393126000862	ABC-ATPase subunit interface; other site
393126000863	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393126000864	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000865	dimer interface [polypeptide binding]; other site
393126000866	conserved gate region; other site
393126000867	ABC-ATPase subunit interface; other site
393126000868	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
393126000869	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126000870	beta-galactosidase; Region: BGL; TIGR03356
393126000871	sugar phosphate phosphatase; Provisional; Region: PRK10513
393126000872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000873	active site
393126000874	motif I; other site
393126000875	motif II; other site
393126000876	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000877	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126000878	Coenzyme A binding pocket [chemical binding]; other site
393126000879	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000880	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126000881	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
393126000882	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393126000883	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000884	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
393126000885	active site
393126000886	motif I; other site
393126000887	motif II; other site
393126000888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126000889	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126000890	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126000891	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393126000892	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
393126000893	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
393126000894	Walker A/P-loop; other site
393126000895	ATP binding site [chemical binding]; other site
393126000896	Q-loop/lid; other site
393126000897	ABC transporter signature motif; other site
393126000898	Walker B; other site
393126000899	D-loop; other site
393126000900	H-loop/switch region; other site
393126000901	TOBE domain; Region: TOBE; pfam03459
393126000902	ATP cone domain; Region: ATP-cone; pfam03477
393126000903	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
393126000904	Class III ribonucleotide reductase; Region: RNR_III; cd01675
393126000905	effector binding site; other site
393126000906	active site
393126000907	Zn binding site [ion binding]; other site
393126000908	glycine loop; other site
393126000909	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
393126000910	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
393126000911	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126000912	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126000913	ligand binding site [chemical binding]; other site
393126000914	flexible hinge region; other site
393126000915	Predicted amidohydrolase [General function prediction only]; Region: COG0388
393126000916	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
393126000917	putative active site [active]
393126000918	catalytic triad [active]
393126000919	putative dimer interface [polypeptide binding]; other site
393126000920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126000921	dimer interface [polypeptide binding]; other site
393126000922	conserved gate region; other site
393126000923	ABC-ATPase subunit interface; other site
393126000924	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
393126000925	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
393126000926	Walker A/P-loop; other site
393126000927	ATP binding site [chemical binding]; other site
393126000928	Q-loop/lid; other site
393126000929	ABC transporter signature motif; other site
393126000930	Walker B; other site
393126000931	D-loop; other site
393126000932	H-loop/switch region; other site
393126000933	NIL domain; Region: NIL; pfam09383
393126000934	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
393126000935	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
393126000936	transaminase; Reviewed; Region: PRK08068
393126000937	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126000938	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126000939	homodimer interface [polypeptide binding]; other site
393126000940	catalytic residue [active]
393126000941	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126000942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126000943	active site
393126000944	phosphorylation site [posttranslational modification]
393126000945	intermolecular recognition site; other site
393126000946	dimerization interface [polypeptide binding]; other site
393126000947	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126000948	DNA binding site [nucleotide binding]
393126000949	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
393126000950	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126000951	dimerization interface [polypeptide binding]; other site
393126000952	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393126000953	putative active site [active]
393126000954	heme pocket [chemical binding]; other site
393126000955	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126000956	dimer interface [polypeptide binding]; other site
393126000957	phosphorylation site [posttranslational modification]
393126000958	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126000959	ATP binding site [chemical binding]; other site
393126000960	Mg2+ binding site [ion binding]; other site
393126000961	G-X-G motif; other site
393126000962	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
393126000963	YycH protein; Region: YycH; pfam07435
393126000964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
393126000965	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
393126000966	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
393126000967	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
393126000968	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
393126000969	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
393126000970	protein binding site [polypeptide binding]; other site
393126000971	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
393126000972	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126000973	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126000974	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393126000975	dimerization interface [polypeptide binding]; other site
393126000976	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393126000977	dimer interface [polypeptide binding]; other site
393126000978	FMN binding site [chemical binding]; other site
393126000979	NADPH bind site [chemical binding]; other site
393126000980	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126000981	HTH domain; Region: HTH_11; pfam08279
393126000982	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126000983	PRD domain; Region: PRD; pfam00874
393126000984	PRD domain; Region: PRD; pfam00874
393126000985	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126000986	active site
393126000987	P-loop; other site
393126000988	phosphorylation site [posttranslational modification]
393126000989	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126000990	active site
393126000991	phosphorylation site [posttranslational modification]
393126000992	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126000993	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126000994	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126000995	active site
393126000996	P-loop; other site
393126000997	phosphorylation site [posttranslational modification]
393126000998	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126000999	beta-galactosidase; Region: BGL; TIGR03356
393126001000	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126001001	methionine cluster; other site
393126001002	active site
393126001003	phosphorylation site [posttranslational modification]
393126001004	metal binding site [ion binding]; metal-binding site
393126001005	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
393126001006	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
393126001007	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
393126001008	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
393126001009	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126001010	catalytic residue [active]
393126001011	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
393126001012	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
393126001013	nucleophilic elbow; other site
393126001014	catalytic triad; other site
393126001015	Uncharacterized conserved protein [Function unknown]; Region: COG1479
393126001016	Protein of unknown function DUF262; Region: DUF262; pfam03235
393126001017	Protein of unknown function DUF262; Region: DUF262; pfam03235
393126001018	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
393126001019	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
393126001020	Ligand Binding Site [chemical binding]; other site
393126001021	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
393126001022	active site
393126001023	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
393126001024	putative active site [active]
393126001025	YdjC motif; other site
393126001026	Mg binding site [ion binding]; other site
393126001027	putative homodimer interface [polypeptide binding]; other site
393126001028	Putative transcription activator [Transcription]; Region: TenA; COG0819
393126001029	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
393126001030	substrate binding site [chemical binding]; other site
393126001031	multimerization interface [polypeptide binding]; other site
393126001032	ATP binding site [chemical binding]; other site
393126001033	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
393126001034	dimer interface [polypeptide binding]; other site
393126001035	substrate binding site [chemical binding]; other site
393126001036	ATP binding site [chemical binding]; other site
393126001037	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
393126001038	thiamine phosphate binding site [chemical binding]; other site
393126001039	active site
393126001040	pyrophosphate binding site [ion binding]; other site
393126001041	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126001042	beta-galactosidase; Region: BGL; TIGR03356
393126001043	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126001044	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
393126001045	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
393126001046	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
393126001047	putative catalytic site [active]
393126001048	putative metal binding site [ion binding]; other site
393126001049	putative phosphate binding site [ion binding]; other site
393126001050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126001051	non-specific DNA binding site [nucleotide binding]; other site
393126001052	salt bridge; other site
393126001053	sequence-specific DNA binding site [nucleotide binding]; other site
393126001054	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393126001055	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126001056	non-specific DNA binding site [nucleotide binding]; other site
393126001057	salt bridge; other site
393126001058	sequence-specific DNA binding site [nucleotide binding]; other site
393126001059	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393126001060	Leucine rich repeat; Region: LRR_8; pfam13855
393126001061	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001062	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001063	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001064	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001065	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001066	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001067	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001068	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001069	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001070	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001071	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001072	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001073	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001074	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001075	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001076	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393126001077	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126001078	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126001079	Leucine-rich repeats; other site
393126001080	Substrate binding site [chemical binding]; other site
393126001081	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001082	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001083	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001084	Leucine rich repeat; Region: LRR_8; pfam13855
393126001085	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126001086	Leucine-rich repeats; other site
393126001087	Substrate binding site [chemical binding]; other site
393126001088	Leucine rich repeat; Region: LRR_8; pfam13855
393126001089	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001090	Leucine rich repeat; Region: LRR_8; pfam13855
393126001091	Leucine rich repeat; Region: LRR_8; pfam13855
393126001092	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001093	LRR adjacent; Region: LRR_adjacent; pfam08191
393126001094	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001095	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001096	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001097	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
393126001098	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
393126001099	LXG domain of WXG superfamily; Region: LXG; pfam04740
393126001100	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
393126001101	Enterocin A Immunity; Region: EntA_Immun; pfam08951
393126001102	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393126001103	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393126001104	TPP-binding site [chemical binding]; other site
393126001105	dimer interface [polypeptide binding]; other site
393126001106	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393126001107	PYR/PP interface [polypeptide binding]; other site
393126001108	dimer interface [polypeptide binding]; other site
393126001109	TPP binding site [chemical binding]; other site
393126001110	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126001111	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
393126001112	active site
393126001113	intersubunit interactions; other site
393126001114	catalytic residue [active]
393126001115	short chain dehydrogenase; Provisional; Region: PRK06841
393126001116	classical (c) SDRs; Region: SDR_c; cd05233
393126001117	NAD(P) binding site [chemical binding]; other site
393126001118	active site
393126001119	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393126001120	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
393126001121	substrate binding site [chemical binding]; other site
393126001122	dimer interface [polypeptide binding]; other site
393126001123	catalytic triad [active]
393126001124	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393126001125	DAK2 domain; Region: Dak2; cl03685
393126001126	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
393126001127	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393126001128	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
393126001129	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126001130	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126001131	putative DNA binding site [nucleotide binding]; other site
393126001132	putative Zn2+ binding site [ion binding]; other site
393126001133	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126001134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126001135	Coenzyme A binding pocket [chemical binding]; other site
393126001136	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
393126001137	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
393126001138	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
393126001139	acyl-activating enzyme (AAE) consensus motif; other site
393126001140	acyl-activating enzyme (AAE) consensus motif; other site
393126001141	AMP binding site [chemical binding]; other site
393126001142	active site
393126001143	CoA binding site [chemical binding]; other site
393126001144	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
393126001145	L-aspartate oxidase; Provisional; Region: PRK06175
393126001146	putative oxidoreductase; Provisional; Region: PRK10206
393126001147	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126001148	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393126001149	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001150	active site
393126001151	phosphorylation site [posttranslational modification]
393126001152	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
393126001153	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126001154	active site
393126001155	P-loop; other site
393126001156	phosphorylation site [posttranslational modification]
393126001157	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126001158	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393126001159	intersubunit interface [polypeptide binding]; other site
393126001160	active site
393126001161	zinc binding site [ion binding]; other site
393126001162	Na+ binding site [ion binding]; other site
393126001163	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126001164	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
393126001165	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126001166	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
393126001167	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
393126001168	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
393126001169	conserved cys residue [active]
393126001170	Predicted transcriptional regulator [Transcription]; Region: COG2378
393126001171	HTH domain; Region: HTH_11; pfam08279
393126001172	WYL domain; Region: WYL; pfam13280
393126001173	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
393126001174	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
393126001175	Imelysin; Region: Peptidase_M75; pfam09375
393126001176	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
393126001177	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
393126001178	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
393126001179	nudix motif; other site
393126001180	hypothetical protein; Provisional; Region: PRK12378
393126001181	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
393126001182	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
393126001183	PhnA protein; Region: PhnA; pfam03831
393126001184	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126001185	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126001186	DNA-binding site [nucleotide binding]; DNA binding site
393126001187	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393126001188	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126001189	beta-galactosidase; Region: BGL; TIGR03356
393126001190	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126001191	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
393126001192	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126001193	active site
393126001194	P-loop; other site
393126001195	phosphorylation site [posttranslational modification]
393126001196	Predicted transcriptional regulator [Transcription]; Region: COG2378
393126001197	HTH domain; Region: HTH_11; pfam08279
393126001198	WYL domain; Region: WYL; pfam13280
393126001199	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126001200	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393126001201	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126001202	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
393126001203	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
393126001204	tetrameric interface [polypeptide binding]; other site
393126001205	NAD binding site [chemical binding]; other site
393126001206	catalytic residues [active]
393126001207	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
393126001208	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
393126001209	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
393126001210	substrate binding site [chemical binding]; other site
393126001211	ATP binding site [chemical binding]; other site
393126001212	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
393126001213	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393126001214	PYR/PP interface [polypeptide binding]; other site
393126001215	dimer interface [polypeptide binding]; other site
393126001216	TPP binding site [chemical binding]; other site
393126001217	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393126001218	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
393126001219	TPP-binding site; other site
393126001220	Uncharacterized conserved protein [Function unknown]; Region: COG5646
393126001221	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
393126001222	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
393126001223	ligand binding site [chemical binding]; other site
393126001224	active site
393126001225	UGI interface [polypeptide binding]; other site
393126001226	catalytic site [active]
393126001227	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
393126001228	hypothetical protein; Provisional; Region: PRK13665
393126001229	Bacterial SH3 domain; Region: SH3_3; cl17532
393126001230	NlpC/P60 family; Region: NLPC_P60; pfam00877
393126001231	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126001232	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126001233	Coenzyme A binding pocket [chemical binding]; other site
393126001234	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
393126001235	pyrroline-5-carboxylate reductase; Region: PLN02688
393126001236	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
393126001237	putative hydrophobic ligand binding site [chemical binding]; other site
393126001238	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001239	active site
393126001240	phosphorylation site [posttranslational modification]
393126001241	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126001242	alpha-mannosidase; Provisional; Region: PRK09819
393126001243	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393126001244	active site
393126001245	metal binding site [ion binding]; metal-binding site
393126001246	catalytic site [active]
393126001247	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393126001248	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126001249	HTH domain; Region: HTH_11; pfam08279
393126001250	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126001251	PRD domain; Region: PRD; pfam00874
393126001252	PRD domain; Region: PRD; pfam00874
393126001253	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126001254	active site
393126001255	P-loop; other site
393126001256	phosphorylation site [posttranslational modification]
393126001257	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001258	active site
393126001259	phosphorylation site [posttranslational modification]
393126001260	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
393126001261	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
393126001262	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126001263	putative metal binding site [ion binding]; other site
393126001264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
393126001265	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
393126001266	trimer interface [polypeptide binding]; other site
393126001267	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126001268	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393126001269	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126001270	Leucine-rich repeats; other site
393126001271	Substrate binding site [chemical binding]; other site
393126001272	LRR adjacent; Region: LRR_adjacent; pfam08191
393126001273	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001274	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001275	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001276	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001277	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126001278	phosphoenolpyruvate synthase; Validated; Region: PRK06241
393126001279	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
393126001280	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393126001281	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
393126001282	ZIP Zinc transporter; Region: Zip; pfam02535
393126001283	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
393126001284	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
393126001285	NodB motif; other site
393126001286	active site
393126001287	catalytic site [active]
393126001288	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126001289	non-specific DNA binding site [nucleotide binding]; other site
393126001290	salt bridge; other site
393126001291	sequence-specific DNA binding site [nucleotide binding]; other site
393126001292	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
393126001293	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001294	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
393126001295	active site
393126001296	motif I; other site
393126001297	motif II; other site
393126001298	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001299	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393126001300	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
393126001301	Predicted transcriptional regulators [Transcription]; Region: COG1695
393126001302	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
393126001303	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393126001304	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393126001305	DNA binding residues [nucleotide binding]
393126001306	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393126001307	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126001308	HTH domain; Region: HTH_11; pfam08279
393126001309	PRD domain; Region: PRD; pfam00874
393126001310	PRD domain; Region: PRD; pfam00874
393126001311	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126001312	active site
393126001313	P-loop; other site
393126001314	phosphorylation site [posttranslational modification]
393126001315	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001316	active site
393126001317	phosphorylation site [posttranslational modification]
393126001318	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001319	active site
393126001320	phosphorylation site [posttranslational modification]
393126001321	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126001322	active site
393126001323	P-loop; other site
393126001324	phosphorylation site [posttranslational modification]
393126001325	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126001326	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393126001327	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393126001328	active site
393126001329	metal binding site [ion binding]; metal-binding site
393126001330	catalytic site [active]
393126001331	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
393126001332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126001333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126001334	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393126001335	dimerization interface [polypeptide binding]; other site
393126001336	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
393126001337	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
393126001338	active site
393126001339	substrate binding site [chemical binding]; other site
393126001340	trimer interface [polypeptide binding]; other site
393126001341	CoA binding site [chemical binding]; other site
393126001342	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
393126001343	classical (c) SDRs; Region: SDR_c; cd05233
393126001344	NAD(P) binding site [chemical binding]; other site
393126001345	active site
393126001346	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126001347	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001348	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126001349	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001350	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001351	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001352	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001353	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001354	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001355	LRR adjacent; Region: LRR_adjacent; pfam08191
393126001356	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001357	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001358	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001359	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126001360	Leucine rich repeat; Region: LRR_8; pfam13855
393126001361	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126001362	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001363	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001364	LRR adjacent; Region: LRR_adjacent; pfam08191
393126001365	Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543
393126001366	SH3-like domain; Region: SH3_8; pfam13457
393126001367	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126001368	Predicted transcriptional regulator [Transcription]; Region: COG1959
393126001369	Transcriptional regulator; Region: Rrf2; pfam02082
393126001370	Transcriptional regulator; Region: Rrf2; cl17282
393126001371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393126001372	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
393126001373	NAD(P) binding site [chemical binding]; other site
393126001374	active site
393126001375	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
393126001376	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
393126001377	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
393126001378	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393126001379	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
393126001380	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393126001381	Transcriptional regulator [Transcription]; Region: LytR; COG1316
393126001382	Predicted membrane protein [Function unknown]; Region: COG1511
393126001383	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393126001384	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
393126001385	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
393126001386	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
393126001387	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126001388	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
393126001389	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
393126001390	active site
393126001391	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
393126001392	L-tyrosine decarboxylase; Provisional; Region: PRK13520
393126001393	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126001394	catalytic residue [active]
393126001395	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
393126001396	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
393126001397	Predicted membrane protein [Function unknown]; Region: COG3619
393126001398	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
393126001399	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
393126001400	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
393126001401	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
393126001402	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
393126001403	Protein of unknown function DUF58; Region: DUF58; pfam01882
393126001404	MoxR-like ATPases [General function prediction only]; Region: COG0714
393126001405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126001406	Walker A motif; other site
393126001407	ATP binding site [chemical binding]; other site
393126001408	Walker B motif; other site
393126001409	arginine finger; other site
393126001410	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
393126001411	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
393126001412	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
393126001413	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
393126001414	Na binding site [ion binding]; other site
393126001415	Uncharacterized conserved protein [Function unknown]; Region: COG3535
393126001416	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
393126001417	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126001418	nucleotide binding site [chemical binding]; other site
393126001419	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
393126001420	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126001421	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
393126001422	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001423	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001424	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
393126001425	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001426	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001427	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001428	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001429	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001430	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393126001431	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393126001432	Helix-turn-helix domain; Region: HTH_17; cl17695
393126001433	Domain of unknown function (DUF4365); Region: DUF4365; pfam14280
393126001434	DNA methylase; Region: N6_N4_Mtase; pfam01555
393126001435	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
393126001436	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
393126001437	LXG domain of WXG superfamily; Region: LXG; pfam04740
393126001438	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126001439	Zn2+ binding site [ion binding]; other site
393126001440	Mg2+ binding site [ion binding]; other site
393126001441	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393126001442	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393126001443	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393126001444	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
393126001445	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126001446	Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487
393126001447	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
393126001448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393126001449	FeS/SAM binding site; other site
393126001450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
393126001451	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
393126001452	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
393126001453	putative FMN binding site [chemical binding]; other site
393126001454	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
393126001455	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
393126001456	nudix motif; other site
393126001457	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126001458	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126001459	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393126001460	putative dimerization interface [polypeptide binding]; other site
393126001461	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
393126001462	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
393126001463	active site
393126001464	FMN binding site [chemical binding]; other site
393126001465	substrate binding site [chemical binding]; other site
393126001466	putative catalytic residue [active]
393126001467	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
393126001468	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126001469	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126001470	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
393126001471	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393126001472	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393126001473	shikimate binding site; other site
393126001474	NAD(P) binding site [chemical binding]; other site
393126001475	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
393126001476	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
393126001477	active site
393126001478	catalytic residue [active]
393126001479	dimer interface [polypeptide binding]; other site
393126001480	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126001481	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126001482	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
393126001483	dimerization interface [polypeptide binding]; other site
393126001484	substrate binding pocket [chemical binding]; other site
393126001485	Predicted acyl esterases [General function prediction only]; Region: COG2936
393126001486	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
393126001487	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
393126001488	active site
393126001489	catalytic triad [active]
393126001490	oxyanion hole [active]
393126001491	EamA-like transporter family; Region: EamA; pfam00892
393126001492	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
393126001493	EamA-like transporter family; Region: EamA; pfam00892
393126001494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
393126001495	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393126001496	active site
393126001497	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393126001498	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126001499	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126001500	substrate binding site [chemical binding]; other site
393126001501	hexamer interface [polypeptide binding]; other site
393126001502	metal binding site [ion binding]; metal-binding site
393126001503	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
393126001504	catalytic residue [active]
393126001505	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126001506	PRD domain; Region: PRD; pfam00874
393126001507	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126001508	active site
393126001509	P-loop; other site
393126001510	phosphorylation site [posttranslational modification]
393126001511	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001512	active site
393126001513	phosphorylation site [posttranslational modification]
393126001514	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
393126001515	putative active site [active]
393126001516	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001517	active site
393126001518	phosphorylation site [posttranslational modification]
393126001519	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126001520	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126001521	substrate binding site [chemical binding]; other site
393126001522	hexamer interface [polypeptide binding]; other site
393126001523	metal binding site [ion binding]; metal-binding site
393126001524	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393126001525	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
393126001526	putative NAD(P) binding site [chemical binding]; other site
393126001527	catalytic Zn binding site [ion binding]; other site
393126001528	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393126001529	active site
393126001530	P-loop; other site
393126001531	phosphorylation site [posttranslational modification]
393126001532	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393126001533	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393126001534	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
393126001535	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
393126001536	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126001537	active site
393126001538	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
393126001539	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
393126001540	catalytic triad [active]
393126001541	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
393126001542	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126001543	MarR family; Region: MarR_2; pfam12802
393126001544	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001545	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126001546	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393126001547	Ligand Binding Site [chemical binding]; other site
393126001548	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
393126001549	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
393126001550	putative active site [active]
393126001551	putative metal binding site [ion binding]; other site
393126001552	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126001553	catalytic core [active]
393126001554	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126001555	Predicted membrane protein [Function unknown]; Region: COG3759
393126001556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126001557	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126001558	putative substrate translocation pore; other site
393126001559	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393126001560	non-specific DNA interactions [nucleotide binding]; other site
393126001561	DNA binding site [nucleotide binding]
393126001562	sequence specific DNA binding site [nucleotide binding]; other site
393126001563	putative cAMP binding site [chemical binding]; other site
393126001564	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126001565	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
393126001566	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
393126001567	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
393126001568	NAD binding site [chemical binding]; other site
393126001569	sugar binding site [chemical binding]; other site
393126001570	divalent metal binding site [ion binding]; other site
393126001571	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126001572	dimer interface [polypeptide binding]; other site
393126001573	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126001574	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126001575	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126001576	putative active site [active]
393126001577	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
393126001578	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
393126001579	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393126001580	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
393126001581	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393126001582	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393126001583	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
393126001584	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
393126001585	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393126001586	DNA binding residues [nucleotide binding]
393126001587	dimer interface [polypeptide binding]; other site
393126001588	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
393126001589	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
393126001590	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
393126001591	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
393126001592	DXD motif; other site
393126001593	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
393126001594	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393126001595	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126001596	S-adenosylmethionine binding site [chemical binding]; other site
393126001597	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
393126001598	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
393126001599	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126001600	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126001601	DNA binding site [nucleotide binding]
393126001602	domain linker motif; other site
393126001603	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
393126001604	putative dimerization interface [polypeptide binding]; other site
393126001605	putative ligand binding site [chemical binding]; other site
393126001606	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
393126001607	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
393126001608	NAD binding site [chemical binding]; other site
393126001609	sugar binding site [chemical binding]; other site
393126001610	divalent metal binding site [ion binding]; other site
393126001611	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126001612	dimer interface [polypeptide binding]; other site
393126001613	allantoate amidohydrolase; Reviewed; Region: PRK09290
393126001614	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
393126001615	active site
393126001616	metal binding site [ion binding]; metal-binding site
393126001617	dimer interface [polypeptide binding]; other site
393126001618	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393126001619	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
393126001620	metal binding site [ion binding]; metal-binding site
393126001621	putative dimer interface [polypeptide binding]; other site
393126001622	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
393126001623	Beta-lactamase; Region: Beta-lactamase; pfam00144
393126001624	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
393126001625	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
393126001626	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
393126001627	intersubunit interface [polypeptide binding]; other site
393126001628	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
393126001629	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
393126001630	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
393126001631	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
393126001632	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
393126001633	Glucitol operon activator protein (GutM); Region: GutM; cl01890
393126001634	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
393126001635	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126001636	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
393126001637	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393126001638	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393126001639	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126001640	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001641	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001642	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001643	WxL domain surface cell wall-binding; Region: WxL; pfam13731
393126001644	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126001645	WxL domain surface cell wall-binding; Region: WxL; pfam13731
393126001646	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
393126001647	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
393126001648	FOG: CBS domain [General function prediction only]; Region: COG0517
393126001649	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
393126001650	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
393126001651	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
393126001652	dimer interface [polypeptide binding]; other site
393126001653	active site
393126001654	metal binding site [ion binding]; metal-binding site
393126001655	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
393126001656	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126001657	putative substrate translocation pore; other site
393126001658	POT family; Region: PTR2; pfam00854
393126001659	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126001660	catalytic core [active]
393126001661	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126001662	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126001663	catalytic core [active]
393126001664	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
393126001665	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
393126001666	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393126001667	Cl binding site [ion binding]; other site
393126001668	oligomer interface [polypeptide binding]; other site
393126001669	glutamate dehydrogenase; Provisional; Region: PRK09414
393126001670	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
393126001671	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
393126001672	NAD(P) binding site [chemical binding]; other site
393126001673	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
393126001674	metal binding site [ion binding]; metal-binding site
393126001675	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
393126001676	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
393126001677	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
393126001678	substrate binding site [chemical binding]; other site
393126001679	glutamase interaction surface [polypeptide binding]; other site
393126001680	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
393126001681	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
393126001682	catalytic residues [active]
393126001683	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
393126001684	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
393126001685	putative active site [active]
393126001686	oxyanion strand; other site
393126001687	catalytic triad [active]
393126001688	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
393126001689	putative active site pocket [active]
393126001690	4-fold oligomerization interface [polypeptide binding]; other site
393126001691	metal binding residues [ion binding]; metal-binding site
393126001692	3-fold/trimer interface [polypeptide binding]; other site
393126001693	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
393126001694	histidinol dehydrogenase; Region: hisD; TIGR00069
393126001695	NAD binding site [chemical binding]; other site
393126001696	dimerization interface [polypeptide binding]; other site
393126001697	product binding site; other site
393126001698	substrate binding site [chemical binding]; other site
393126001699	zinc binding site [ion binding]; other site
393126001700	catalytic residues [active]
393126001701	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
393126001702	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
393126001703	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
393126001704	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
393126001705	dimer interface [polypeptide binding]; other site
393126001706	motif 1; other site
393126001707	active site
393126001708	motif 2; other site
393126001709	motif 3; other site
393126001710	histidinol-phosphatase; Reviewed; Region: PRK08123
393126001711	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
393126001712	active site
393126001713	dimer interface [polypeptide binding]; other site
393126001714	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393126001715	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393126001716	DNA binding site [nucleotide binding]
393126001717	active site
393126001718	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
393126001719	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393126001720	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126001721	beta-galactosidase; Region: BGL; TIGR03356
393126001722	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126001723	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126001724	DNA-binding site [nucleotide binding]; DNA binding site
393126001725	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393126001726	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001727	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126001728	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
393126001729	Uncharacterized conserved protein [Function unknown]; Region: COG2966
393126001730	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
393126001731	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
393126001732	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
393126001733	Predicted esterase [General function prediction only]; Region: COG0400
393126001734	putative hydrolase; Provisional; Region: PRK11460
393126001735	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
393126001736	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
393126001737	putative RNA binding site [nucleotide binding]; other site
393126001738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126001739	S-adenosylmethionine binding site [chemical binding]; other site
393126001740	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
393126001741	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126001742	Bacterial SH3 domain; Region: SH3_3; pfam08239
393126001743	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126001744	NlpC/P60 family; Region: NLPC_P60; pfam00877
393126001745	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
393126001746	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393126001747	ATP binding site [chemical binding]; other site
393126001748	putative Mg++ binding site [ion binding]; other site
393126001749	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
393126001750	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
393126001751	nucleotide binding region [chemical binding]; other site
393126001752	ATP-binding site [chemical binding]; other site
393126001753	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393126001754	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393126001755	WxL domain surface cell wall-binding; Region: WxL; pfam13731
393126001756	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
393126001757	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
393126001758	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
393126001759	DNA photolyase; Region: DNA_photolyase; pfam00875
393126001760	Predicted membrane protein [Function unknown]; Region: COG4852
393126001761	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
393126001762	DAK2 domain; Region: Dak2; pfam02734
393126001763	EDD domain protein, DegV family; Region: DegV; TIGR00762
393126001764	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393126001765	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
393126001766	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
393126001767	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
393126001768	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
393126001769	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
393126001770	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393126001771	homodimer interface [polypeptide binding]; other site
393126001772	substrate-cofactor binding pocket; other site
393126001773	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126001774	catalytic residue [active]
393126001775	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
393126001776	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126001777	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393126001778	ligand binding site [chemical binding]; other site
393126001779	flexible hinge region; other site
393126001780	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126001781	BioY family; Region: BioY; pfam02632
393126001782	Predicted transcriptional regulators [Transcription]; Region: COG1695
393126001783	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
393126001784	Predicted membrane protein [Function unknown]; Region: COG4709
393126001785	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393126001786	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393126001787	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393126001788	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393126001789	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126001790	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393126001791	Coenzyme A binding pocket [chemical binding]; other site
393126001792	Tic20-like protein; Region: Tic20; pfam09685
393126001793	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
393126001794	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393126001795	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126001796	MarR family; Region: MarR_2; pfam12802
393126001797	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126001798	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126001799	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126001800	Walker A/P-loop; other site
393126001801	ATP binding site [chemical binding]; other site
393126001802	Q-loop/lid; other site
393126001803	ABC transporter signature motif; other site
393126001804	Walker B; other site
393126001805	D-loop; other site
393126001806	H-loop/switch region; other site
393126001807	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126001808	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126001809	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
393126001810	Walker A/P-loop; other site
393126001811	ATP binding site [chemical binding]; other site
393126001812	Q-loop/lid; other site
393126001813	ABC transporter signature motif; other site
393126001814	Walker B; other site
393126001815	D-loop; other site
393126001816	H-loop/switch region; other site
393126001817	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
393126001818	active site residue [active]
393126001819	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001820	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126001821	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393126001822	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393126001823	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126001824	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126001825	putative DNA binding site [nucleotide binding]; other site
393126001826	putative Zn2+ binding site [ion binding]; other site
393126001827	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
393126001828	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
393126001829	putative NAD(P) binding site [chemical binding]; other site
393126001830	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393126001831	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393126001832	Coenzyme A binding pocket [chemical binding]; other site
393126001833	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
393126001834	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
393126001835	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
393126001836	putative active site [active]
393126001837	catalytic site [active]
393126001838	putative metal binding site [ion binding]; other site
393126001839	Catalytic domain of Protein Kinases; Region: PKc; cd00180
393126001840	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
393126001841	active site
393126001842	ATP binding site [chemical binding]; other site
393126001843	substrate binding site [chemical binding]; other site
393126001844	activation loop (A-loop); other site
393126001845	Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915
393126001846	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
393126001847	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
393126001848	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393126001849	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126001850	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126001851	Coenzyme A binding pocket [chemical binding]; other site
393126001852	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
393126001853	active site
393126001854	catalytic triad [active]
393126001855	oxyanion hole [active]
393126001856	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393126001857	domain interaction interfaces [polypeptide binding]; other site
393126001858	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393126001859	domain interaction interfaces [polypeptide binding]; other site
393126001860	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393126001861	domain interaction interfaces [polypeptide binding]; other site
393126001862	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393126001863	domain interaction interfaces [polypeptide binding]; other site
393126001864	Isochorismatase family; Region: Isochorismatase; pfam00857
393126001865	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
393126001866	catalytic triad [active]
393126001867	conserved cis-peptide bond; other site
393126001868	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126001869	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126001870	PRD domain; Region: PRD; pfam00874
393126001871	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126001872	active site
393126001873	P-loop; other site
393126001874	phosphorylation site [posttranslational modification]
393126001875	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
393126001876	active site
393126001877	phosphorylation site [posttranslational modification]
393126001878	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126001879	active site
393126001880	phosphorylation site [posttranslational modification]
393126001881	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
393126001882	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126001883	active site
393126001884	P-loop; other site
393126001885	phosphorylation site [posttranslational modification]
393126001886	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
393126001887	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
393126001888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001889	motif II; other site
393126001890	Predicted transcriptional regulator [Transcription]; Region: COG1959
393126001891	Transcriptional regulator; Region: Rrf2; pfam02082
393126001892	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393126001893	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126001894	S-adenosylmethionine binding site [chemical binding]; other site
393126001895	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393126001896	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
393126001897	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126001898	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126001899	active site
393126001900	catalytic tetrad [active]
393126001901	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
393126001902	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126001903	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001904	motif II; other site
393126001905	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
393126001906	catalytic residue [active]
393126001907	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
393126001908	Sulfatase; Region: Sulfatase; pfam00884
393126001909	amino acid transporter; Region: 2A0306; TIGR00909
393126001910	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
393126001911	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
393126001912	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
393126001913	putative metal binding site [ion binding]; other site
393126001914	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
393126001915	active site
393126001916	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
393126001917	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393126001918	Cl binding site [ion binding]; other site
393126001919	oligomer interface [polypeptide binding]; other site
393126001920	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393126001921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126001922	DNA-binding site [nucleotide binding]; DNA binding site
393126001923	Predicted membrane protein [Function unknown]; Region: COG1511
393126001924	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393126001925	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
393126001926	linker region; other site
393126001927	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126001928	Transcriptional regulators [Transcription]; Region: FadR; COG2186
393126001929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126001930	DNA-binding site [nucleotide binding]; DNA binding site
393126001931	FCD domain; Region: FCD; cl11656
393126001932	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393126001933	Predicted integral membrane protein [Function unknown]; Region: COG5523
393126001934	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393126001935	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
393126001936	active site
393126001937	metal binding site [ion binding]; metal-binding site
393126001938	Predicted membrane protein [Function unknown]; Region: COG2322
393126001939	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
393126001940	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393126001941	minor groove reading motif; other site
393126001942	helix-hairpin-helix signature motif; other site
393126001943	substrate binding pocket [chemical binding]; other site
393126001944	active site
393126001945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126001946	non-specific DNA binding site [nucleotide binding]; other site
393126001947	salt bridge; other site
393126001948	sequence-specific DNA binding site [nucleotide binding]; other site
393126001949	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393126001950	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
393126001951	Helix-turn-helix domain; Region: HTH_28; pfam13518
393126001952	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
393126001953	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
393126001954	dimer interface [polypeptide binding]; other site
393126001955	substrate binding site [chemical binding]; other site
393126001956	ATP binding site [chemical binding]; other site
393126001957	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126001958	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001959	active site
393126001960	motif I; other site
393126001961	motif II; other site
393126001962	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126001963	maltose O-acetyltransferase; Provisional; Region: PRK10092
393126001964	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
393126001965	active site
393126001966	substrate binding site [chemical binding]; other site
393126001967	trimer interface [polypeptide binding]; other site
393126001968	CoA binding site [chemical binding]; other site
393126001969	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
393126001970	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126001971	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126001972	Walker A/P-loop; other site
393126001973	ATP binding site [chemical binding]; other site
393126001974	Q-loop/lid; other site
393126001975	ABC transporter signature motif; other site
393126001976	Walker B; other site
393126001977	D-loop; other site
393126001978	H-loop/switch region; other site
393126001979	inner membrane transport permease; Provisional; Region: PRK15066
393126001980	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393126001981	oxidoreductase; Provisional; Region: PRK07985
393126001982	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393126001983	NAD(P) binding site [chemical binding]; other site
393126001984	active site
393126001985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
393126001986	Predicted membrane protein [Function unknown]; Region: COG3152
393126001987	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
393126001988	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
393126001989	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
393126001990	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
393126001991	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
393126001992	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
393126001993	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
393126001994	FHIPEP family; Region: FHIPEP; pfam00771
393126001995	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
393126001996	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393126001997	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
393126001998	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393126001999	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
393126002000	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
393126002001	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
393126002002	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
393126002003	flagellar motor protein MotA; Validated; Region: PRK08124
393126002004	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
393126002005	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
393126002006	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
393126002007	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
393126002008	ligand binding site [chemical binding]; other site
393126002009	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
393126002010	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
393126002011	putative metal binding site; other site
393126002012	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126002013	binding surface
393126002014	TPR motif; other site
393126002015	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
393126002016	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
393126002017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126002018	active site
393126002019	phosphorylation site [posttranslational modification]
393126002020	intermolecular recognition site; other site
393126002021	dimerization interface [polypeptide binding]; other site
393126002022	flagellin; Provisional; Region: PRK12805
393126002023	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
393126002024	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
393126002025	Response regulator receiver domain; Region: Response_reg; pfam00072
393126002026	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126002027	active site
393126002028	phosphorylation site [posttranslational modification]
393126002029	intermolecular recognition site; other site
393126002030	dimerization interface [polypeptide binding]; other site
393126002031	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
393126002032	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
393126002033	putative binding surface; other site
393126002034	active site
393126002035	P2 response regulator binding domain; Region: P2; pfam07194
393126002036	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
393126002037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126002038	ATP binding site [chemical binding]; other site
393126002039	Mg2+ binding site [ion binding]; other site
393126002040	G-X-G motif; other site
393126002041	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
393126002042	flagellar motor switch protein; Validated; Region: PRK06788
393126002043	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
393126002044	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
393126002045	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
393126002046	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
393126002047	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
393126002048	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
393126002049	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393126002050	flagellar motor switch protein; Validated; Region: PRK06789
393126002051	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
393126002052	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
393126002053	flagellar motor switch protein; Reviewed; Region: PRK06782
393126002054	CheC-like family; Region: CheC; pfam04509
393126002055	CheC-like family; Region: CheC; pfam04509
393126002056	Chemotaxis phosphatase CheX; Region: CheX; cl15816
393126002057	CheC-like family; Region: CheC; pfam04509
393126002058	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
393126002059	Protein of unknown function (DUF327); Region: DUF327; pfam03885
393126002060	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
393126002061	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393126002062	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
393126002063	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
393126002064	flagellar capping protein; Validated; Region: fliD; PRK06798
393126002065	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
393126002066	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
393126002067	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
393126002068	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
393126002069	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
393126002070	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
393126002071	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393126002072	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
393126002073	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
393126002074	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
393126002075	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
393126002076	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
393126002077	FliG C-terminal domain; Region: FliG_C; pfam01706
393126002078	flagellar assembly protein H; Validated; Region: fliH; PRK06800
393126002079	Flagellar assembly protein FliH; Region: FliH; pfam02108
393126002080	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
393126002081	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393126002082	Walker A motif; other site
393126002083	ATP binding site [chemical binding]; other site
393126002084	Walker B motif; other site
393126002085	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
393126002086	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
393126002087	N-acetyl-D-glucosamine binding site [chemical binding]; other site
393126002088	catalytic residue [active]
393126002089	Predicted transcriptional regulators [Transcription]; Region: COG1695
393126002090	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
393126002091	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
393126002092	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
393126002093	pyruvate oxidase; Provisional; Region: PRK08611
393126002094	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
393126002095	PYR/PP interface [polypeptide binding]; other site
393126002096	dimer interface [polypeptide binding]; other site
393126002097	tetramer interface [polypeptide binding]; other site
393126002098	TPP binding site [chemical binding]; other site
393126002099	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393126002100	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
393126002101	TPP-binding site [chemical binding]; other site
393126002102	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
393126002103	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
393126002104	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126002105	dimerization interface [polypeptide binding]; other site
393126002106	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
393126002107	dimer interface [polypeptide binding]; other site
393126002108	putative CheW interface [polypeptide binding]; other site
393126002109	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
393126002110	putative active site [active]
393126002111	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
393126002112	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
393126002113	glutaminase active site [active]
393126002114	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393126002115	dimer interface [polypeptide binding]; other site
393126002116	active site
393126002117	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393126002118	dimer interface [polypeptide binding]; other site
393126002119	active site
393126002120	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
393126002121	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
393126002122	active site
393126002123	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
393126002124	GIY-YIG motif/motif A; other site
393126002125	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126002126	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126002127	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002128	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126002129	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126002130	non-specific DNA binding site [nucleotide binding]; other site
393126002131	salt bridge; other site
393126002132	sequence-specific DNA binding site [nucleotide binding]; other site
393126002133	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126002134	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126002135	DNA binding site [nucleotide binding]
393126002136	domain linker motif; other site
393126002137	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126002138	ligand binding site [chemical binding]; other site
393126002139	dimerization interface [polypeptide binding]; other site
393126002140	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126002141	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126002142	substrate binding site [chemical binding]; other site
393126002143	hexamer interface [polypeptide binding]; other site
393126002144	metal binding site [ion binding]; metal-binding site
393126002145	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
393126002146	BtpA family; Region: BtpA; cl00440
393126002147	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
393126002148	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393126002149	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126002150	active site turn [active]
393126002151	phosphorylation site [posttranslational modification]
393126002152	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126002153	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393126002154	HPr interaction site; other site
393126002155	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126002156	active site
393126002157	phosphorylation site [posttranslational modification]
393126002158	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126002159	beta-galactosidase; Region: BGL; TIGR03356
393126002160	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126002161	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126002162	ligand binding site [chemical binding]; other site
393126002163	flexible hinge region; other site
393126002164	Predicted transcriptional regulators [Transcription]; Region: COG1725
393126002165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002166	DNA-binding site [nucleotide binding]; DNA binding site
393126002167	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
393126002168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126002169	Walker A/P-loop; other site
393126002170	ATP binding site [chemical binding]; other site
393126002171	Q-loop/lid; other site
393126002172	ABC transporter signature motif; other site
393126002173	Walker B; other site
393126002174	D-loop; other site
393126002175	H-loop/switch region; other site
393126002176	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126002177	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126002178	Walker A/P-loop; other site
393126002179	ATP binding site [chemical binding]; other site
393126002180	Q-loop/lid; other site
393126002181	ABC transporter signature motif; other site
393126002182	Walker B; other site
393126002183	D-loop; other site
393126002184	H-loop/switch region; other site
393126002185	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126002186	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393126002187	FtsX-like permease family; Region: FtsX; pfam02687
393126002188	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126002189	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126002190	non-specific DNA binding site [nucleotide binding]; other site
393126002191	salt bridge; other site
393126002192	sequence-specific DNA binding site [nucleotide binding]; other site
393126002193	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393126002194	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126002195	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393126002196	ligand binding site [chemical binding]; other site
393126002197	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393126002198	non-specific DNA interactions [nucleotide binding]; other site
393126002199	DNA binding site [nucleotide binding]
393126002200	sequence specific DNA binding site [nucleotide binding]; other site
393126002201	putative cAMP binding site [chemical binding]; other site
393126002202	SnoaL-like domain; Region: SnoaL_4; pfam13577
393126002203	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
393126002204	active site
393126002205	catalytic triad [active]
393126002206	oxyanion hole [active]
393126002207	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126002208	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126002209	Walker A/P-loop; other site
393126002210	ATP binding site [chemical binding]; other site
393126002211	Q-loop/lid; other site
393126002212	ABC transporter signature motif; other site
393126002213	Walker B; other site
393126002214	D-loop; other site
393126002215	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393126002216	H-loop/switch region; other site
393126002217	active site
393126002218	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
393126002219	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393126002220	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393126002221	Zn binding site [ion binding]; other site
393126002222	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393126002223	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126002224	Zn binding site [ion binding]; other site
393126002225	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393126002226	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126002227	Zn binding site [ion binding]; other site
393126002228	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393126002229	Zn binding site [ion binding]; other site
393126002230	Predicted esterase [General function prediction only]; Region: COG0400
393126002231	putative hydrolase; Provisional; Region: PRK11460
393126002232	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
393126002233	GTPases [General function prediction only]; Region: HflX; COG2262
393126002234	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
393126002235	HflX GTPase family; Region: HflX; cd01878
393126002236	G1 box; other site
393126002237	GTP/Mg2+ binding site [chemical binding]; other site
393126002238	Switch I region; other site
393126002239	G2 box; other site
393126002240	G3 box; other site
393126002241	Switch II region; other site
393126002242	G4 box; other site
393126002243	G5 box; other site
393126002244	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
393126002245	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393126002246	putative active site [active]
393126002247	putative metal binding site [ion binding]; other site
393126002248	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
393126002249	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393126002250	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
393126002251	Uncharacterized conserved protein [Function unknown]; Region: COG3538
393126002252	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
393126002253	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393126002254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002255	dimer interface [polypeptide binding]; other site
393126002256	conserved gate region; other site
393126002257	putative PBP binding loops; other site
393126002258	ABC-ATPase subunit interface; other site
393126002259	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126002260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002261	dimer interface [polypeptide binding]; other site
393126002262	conserved gate region; other site
393126002263	putative PBP binding loops; other site
393126002264	ABC-ATPase subunit interface; other site
393126002265	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393126002266	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
393126002267	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
393126002268	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002269	DNA-binding site [nucleotide binding]; DNA binding site
393126002270	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126002271	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126002272	ligand binding site [chemical binding]; other site
393126002273	dimerization interface [polypeptide binding]; other site
393126002274	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393126002275	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002276	DNA-binding site [nucleotide binding]; DNA binding site
393126002277	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
393126002278	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
393126002279	putative NADP binding site [chemical binding]; other site
393126002280	putative dimer interface [polypeptide binding]; other site
393126002281	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
393126002282	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393126002283	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126002284	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126002285	nucleotide binding site [chemical binding]; other site
393126002286	Predicted membrane protein [Function unknown]; Region: COG4811
393126002287	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
393126002288	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
393126002289	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393126002290	active site
393126002291	phosphorylation site [posttranslational modification]
393126002292	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126002293	active pocket/dimerization site; other site
393126002294	active site
393126002295	phosphorylation site [posttranslational modification]
393126002296	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
393126002297	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126002298	Walker A motif; other site
393126002299	ATP binding site [chemical binding]; other site
393126002300	Walker B motif; other site
393126002301	arginine finger; other site
393126002302	Transcriptional antiterminator [Transcription]; Region: COG3933
393126002303	PRD domain; Region: PRD; pfam00874
393126002304	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126002305	active pocket/dimerization site; other site
393126002306	active site
393126002307	phosphorylation site [posttranslational modification]
393126002308	PRD domain; Region: PRD; pfam00874
393126002309	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
393126002310	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393126002311	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
393126002312	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393126002313	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
393126002314	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393126002315	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
393126002316	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
393126002317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
393126002318	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
393126002319	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393126002320	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
393126002321	putative deacylase active site [active]
393126002322	Predicted amidohydrolase [General function prediction only]; Region: COG0388
393126002323	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
393126002324	active site
393126002325	catalytic triad [active]
393126002326	dimer interface [polypeptide binding]; other site
393126002327	Protein of unknown function (DUF554); Region: DUF554; pfam04474
393126002328	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
393126002329	NADH(P)-binding; Region: NAD_binding_10; pfam13460
393126002330	NAD binding site [chemical binding]; other site
393126002331	substrate binding site [chemical binding]; other site
393126002332	putative active site [active]
393126002333	Predicted permeases [General function prediction only]; Region: RarD; COG2962
393126002334	EamA-like transporter family; Region: EamA; pfam00892
393126002335	Uncharacterized conserved protein [Function unknown]; Region: COG2353
393126002336	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126002337	MarR family; Region: MarR_2; pfam12802
393126002338	lysine transporter; Provisional; Region: PRK10836
393126002339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393126002340	PAS domain; Region: PAS_9; pfam13426
393126002341	putative active site [active]
393126002342	heme pocket [chemical binding]; other site
393126002343	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126002344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
393126002345	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126002346	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126002347	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126002348	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126002349	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126002350	LRR adjacent; Region: LRR_adjacent; pfam08191
393126002351	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126002352	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126002353	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393126002354	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393126002355	synthetase active site [active]
393126002356	NTP binding site [chemical binding]; other site
393126002357	metal binding site [ion binding]; metal-binding site
393126002358	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
393126002359	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
393126002360	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126002361	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126002362	non-specific DNA binding site [nucleotide binding]; other site
393126002363	salt bridge; other site
393126002364	sequence-specific DNA binding site [nucleotide binding]; other site
393126002365	Cupin domain; Region: Cupin_2; pfam07883
393126002366	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
393126002367	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
393126002368	Walker A/P-loop; other site
393126002369	ATP binding site [chemical binding]; other site
393126002370	Q-loop/lid; other site
393126002371	ABC transporter signature motif; other site
393126002372	Walker B; other site
393126002373	D-loop; other site
393126002374	H-loop/switch region; other site
393126002375	TOBE domain; Region: TOBE_2; pfam08402
393126002376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
393126002377	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002378	putative PBP binding loops; other site
393126002379	ABC-ATPase subunit interface; other site
393126002380	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
393126002381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002382	dimer interface [polypeptide binding]; other site
393126002383	conserved gate region; other site
393126002384	putative PBP binding loops; other site
393126002385	ABC-ATPase subunit interface; other site
393126002386	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
393126002387	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
393126002388	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
393126002389	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
393126002390	active site
393126002391	zinc binding site [ion binding]; other site
393126002392	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393126002393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126002394	Zn2+ binding site [ion binding]; other site
393126002395	Mg2+ binding site [ion binding]; other site
393126002396	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126002397	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126002398	nucleotide binding site [chemical binding]; other site
393126002399	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
393126002400	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
393126002401	FMN binding site [chemical binding]; other site
393126002402	substrate binding site [chemical binding]; other site
393126002403	putative catalytic residue [active]
393126002404	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126002405	MarR family; Region: MarR_2; pfam12802
393126002406	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393126002407	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126002408	Coenzyme A binding pocket [chemical binding]; other site
393126002409	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393126002410	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393126002411	dimer interface [polypeptide binding]; other site
393126002412	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126002413	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
393126002414	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
393126002415	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126002416	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393126002417	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126002418	motif II; other site
393126002419	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393126002420	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126002421	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126002422	Coenzyme A binding pocket [chemical binding]; other site
393126002423	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
393126002424	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126002425	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126002426	DNA binding residues [nucleotide binding]
393126002427	putative dimer interface [polypeptide binding]; other site
393126002428	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126002429	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126002430	active site
393126002431	catalytic tetrad [active]
393126002432	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
393126002433	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
393126002434	homodimer interface [polypeptide binding]; other site
393126002435	catalytic residues [active]
393126002436	NAD binding site [chemical binding]; other site
393126002437	substrate binding pocket [chemical binding]; other site
393126002438	flexible flap; other site
393126002439	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
393126002440	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
393126002441	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
393126002442	PhoU domain; Region: PhoU; pfam01895
393126002443	PhoU domain; Region: PhoU; pfam01895
393126002444	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
393126002445	putative transposase OrfB; Reviewed; Region: PHA02517
393126002446	HTH-like domain; Region: HTH_21; pfam13276
393126002447	Integrase core domain; Region: rve; pfam00665
393126002448	Integrase core domain; Region: rve_3; cl15866
393126002449	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
393126002450	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
393126002451	dimer interface [polypeptide binding]; other site
393126002452	PYR/PP interface [polypeptide binding]; other site
393126002453	TPP binding site [chemical binding]; other site
393126002454	substrate binding site [chemical binding]; other site
393126002455	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
393126002456	Domain of unknown function; Region: EKR; smart00890
393126002457	4Fe-4S binding domain; Region: Fer4_6; pfam12837
393126002458	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
393126002459	TPP-binding site [chemical binding]; other site
393126002460	dimer interface [polypeptide binding]; other site
393126002461	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
393126002462	Predicted permeases [General function prediction only]; Region: COG0679
393126002463	Helix-turn-helix domain; Region: HTH_28; pfam13518
393126002464	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126002465	non-specific DNA binding site [nucleotide binding]; other site
393126002466	salt bridge; other site
393126002467	sequence-specific DNA binding site [nucleotide binding]; other site
393126002468	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393126002469	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126002470	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126002471	Predicted membrane protein [Function unknown]; Region: COG3223
393126002472	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126002473	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126002474	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393126002475	Walker A/P-loop; other site
393126002476	ATP binding site [chemical binding]; other site
393126002477	Q-loop/lid; other site
393126002478	ABC transporter signature motif; other site
393126002479	Walker B; other site
393126002480	D-loop; other site
393126002481	H-loop/switch region; other site
393126002482	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
393126002483	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002484	putative substrate translocation pore; other site
393126002485	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002486	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002487	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126002488	putative substrate translocation pore; other site
393126002489	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126002490	MarR family; Region: MarR; pfam01047
393126002491	MarR family; Region: MarR_2; cl17246
393126002492	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
393126002493	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
393126002494	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126002495	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393126002496	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126002497	motif II; other site
393126002498	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393126002499	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002500	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002501	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002502	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002503	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002504	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002505	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126002506	Predicted membrane protein [Function unknown]; Region: COG3326
393126002507	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
393126002508	homotrimer interaction site [polypeptide binding]; other site
393126002509	putative active site [active]
393126002510	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
393126002511	substrate binding site [chemical binding]; other site
393126002512	zinc-binding site [ion binding]; other site
393126002513	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
393126002514	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
393126002515	GIY-YIG motif/motif A; other site
393126002516	active site
393126002517	catalytic site [active]
393126002518	putative DNA binding site [nucleotide binding]; other site
393126002519	metal binding site [ion binding]; metal-binding site
393126002520	UvrB/uvrC motif; Region: UVR; pfam02151
393126002521	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393126002522	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393126002523	substrate binding pocket [chemical binding]; other site
393126002524	membrane-bound complex binding site; other site
393126002525	hinge residues; other site
393126002526	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393126002527	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002528	dimer interface [polypeptide binding]; other site
393126002529	conserved gate region; other site
393126002530	putative PBP binding loops; other site
393126002531	ABC-ATPase subunit interface; other site
393126002532	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393126002533	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393126002534	Walker A/P-loop; other site
393126002535	ATP binding site [chemical binding]; other site
393126002536	Q-loop/lid; other site
393126002537	ABC transporter signature motif; other site
393126002538	Walker B; other site
393126002539	D-loop; other site
393126002540	H-loop/switch region; other site
393126002541	amidase; Provisional; Region: PRK11910
393126002542	Amidase; Region: Amidase; cl11426
393126002543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126002544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126002545	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
393126002546	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
393126002547	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
393126002548	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
393126002549	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
393126002550	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
393126002551	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393126002552	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393126002553	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
393126002554	Esterase/lipase [General function prediction only]; Region: COG1647
393126002555	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126002556	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126002557	DNA binding site [nucleotide binding]
393126002558	domain linker motif; other site
393126002559	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
393126002560	putative dimerization interface [polypeptide binding]; other site
393126002561	putative ligand binding site [chemical binding]; other site
393126002562	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393126002563	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126002564	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
393126002565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002566	dimer interface [polypeptide binding]; other site
393126002567	conserved gate region; other site
393126002568	putative PBP binding loops; other site
393126002569	ABC-ATPase subunit interface; other site
393126002570	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126002571	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126002572	dimer interface [polypeptide binding]; other site
393126002573	conserved gate region; other site
393126002574	ABC-ATPase subunit interface; other site
393126002575	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393126002576	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393126002577	Ca binding site [ion binding]; other site
393126002578	active site
393126002579	catalytic site [active]
393126002580	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
393126002581	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
393126002582	active site
393126002583	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
393126002584	active site
393126002585	substrate binding site [chemical binding]; other site
393126002586	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
393126002587	metal binding site [ion binding]; metal-binding site
393126002588	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393126002589	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393126002590	ATP binding site [chemical binding]; other site
393126002591	Mg++ binding site [ion binding]; other site
393126002592	motif III; other site
393126002593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126002594	nucleotide binding region [chemical binding]; other site
393126002595	ATP-binding site [chemical binding]; other site
393126002596	Predicted membrane protein [Function unknown]; Region: COG4708
393126002597	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
393126002598	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
393126002599	Predicted transcriptional regulators [Transcription]; Region: COG1733
393126002600	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
393126002601	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
393126002602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002603	putative substrate translocation pore; other site
393126002604	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126002605	PRD domain; Region: PRD; pfam00874
393126002606	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126002607	active site
393126002608	P-loop; other site
393126002609	phosphorylation site [posttranslational modification]
393126002610	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126002611	active site
393126002612	phosphorylation site [posttranslational modification]
393126002613	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126002614	methionine cluster; other site
393126002615	active site
393126002616	phosphorylation site [posttranslational modification]
393126002617	metal binding site [ion binding]; metal-binding site
393126002618	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126002619	active site
393126002620	P-loop; other site
393126002621	phosphorylation site [posttranslational modification]
393126002622	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126002623	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126002624	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393126002625	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393126002626	active site
393126002627	trimer interface [polypeptide binding]; other site
393126002628	allosteric site; other site
393126002629	active site lid [active]
393126002630	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393126002631	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126002632	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126002633	active site
393126002634	catalytic tetrad [active]
393126002635	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
393126002636	Collagen binding domain; Region: Collagen_bind; pfam05737
393126002637	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
393126002638	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126002639	Uncharacterized conserved protein [Function unknown]; Region: COG3402
393126002640	Predicted membrane protein [Function unknown]; Region: COG3428
393126002641	Bacterial PH domain; Region: DUF304; pfam03703
393126002642	Bacterial PH domain; Region: DUF304; pfam03703
393126002643	Bacterial PH domain; Region: DUF304; pfam03703
393126002644	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
393126002645	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
393126002646	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
393126002647	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
393126002648	active site
393126002649	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393126002650	dimer interface [polypeptide binding]; other site
393126002651	substrate binding site [chemical binding]; other site
393126002652	catalytic residues [active]
393126002653	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
393126002654	PemK-like protein; Region: PemK; pfam02452
393126002655	Rsbr N terminal; Region: Rsbr_N; pfam08678
393126002656	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126002657	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126002658	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
393126002659	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
393126002660	ATP binding site [chemical binding]; other site
393126002661	Mg2+ binding site [ion binding]; other site
393126002662	G-X-G motif; other site
393126002663	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
393126002664	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
393126002665	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
393126002666	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
393126002667	anti sigma factor interaction site; other site
393126002668	regulatory phosphorylation site [posttranslational modification]; other site
393126002669	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
393126002670	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126002671	ATP binding site [chemical binding]; other site
393126002672	Mg2+ binding site [ion binding]; other site
393126002673	G-X-G motif; other site
393126002674	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
393126002675	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393126002676	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
393126002677	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393126002678	DNA binding residues [nucleotide binding]
393126002679	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
393126002680	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
393126002681	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
393126002682	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393126002683	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
393126002684	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
393126002685	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
393126002686	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
393126002687	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
393126002688	RNA binding site [nucleotide binding]; other site
393126002689	hypothetical protein; Provisional; Region: PRK04351
393126002690	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
393126002691	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
393126002692	Uncharacterized conserved protein [Function unknown]; Region: COG5646
393126002693	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126002694	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126002695	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126002696	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002697	DNA-binding site [nucleotide binding]; DNA binding site
393126002698	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393126002699	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
393126002700	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
393126002701	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
393126002702	glutathione reductase; Validated; Region: PRK06116
393126002703	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126002704	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126002705	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393126002706	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126002707	catalytic core [active]
393126002708	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393126002709	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393126002710	Predicted transcriptional regulators [Transcription]; Region: COG1725
393126002711	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002712	DNA-binding site [nucleotide binding]; DNA binding site
393126002713	Predicted membrane protein [General function prediction only]; Region: COG4194
393126002714	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
393126002715	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
393126002716	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
393126002717	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
393126002718	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
393126002719	tetramerization interface [polypeptide binding]; other site
393126002720	NAD(P) binding site [chemical binding]; other site
393126002721	catalytic residues [active]
393126002722	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
393126002723	active site
393126002724	P-loop; other site
393126002725	phosphorylation site [posttranslational modification]
393126002726	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126002727	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126002728	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126002729	methionine cluster; other site
393126002730	active site
393126002731	phosphorylation site [posttranslational modification]
393126002732	metal binding site [ion binding]; metal-binding site
393126002733	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126002734	beta-galactosidase; Region: BGL; TIGR03356
393126002735	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126002736	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126002737	PRD domain; Region: PRD; pfam00874
393126002738	PRD domain; Region: PRD; pfam00874
393126002739	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
393126002740	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126002741	active site
393126002742	phosphorylation site [posttranslational modification]
393126002743	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126002744	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
393126002745	ABC transporter; Region: ABC_tran_2; pfam12848
393126002746	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126002747	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
393126002748	Predicted permeases [General function prediction only]; Region: COG0701
393126002749	Predicted membrane protein [Function unknown]; Region: COG3689
393126002750	pantothenate kinase; Provisional; Region: PRK05439
393126002751	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
393126002752	ATP-binding site [chemical binding]; other site
393126002753	CoA-binding site [chemical binding]; other site
393126002754	Mg2+-binding site [ion binding]; other site
393126002755	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
393126002756	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126002757	Walker A/P-loop; other site
393126002758	ATP binding site [chemical binding]; other site
393126002759	Q-loop/lid; other site
393126002760	ABC transporter signature motif; other site
393126002761	Walker B; other site
393126002762	D-loop; other site
393126002763	H-loop/switch region; other site
393126002764	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393126002765	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393126002766	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126002767	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126002768	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
393126002769	Domain of unknown function (DUF373); Region: DUF373; cl12079
393126002770	Sulfatase; Region: Sulfatase; pfam00884
393126002771	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
393126002772	active site
393126002773	DNA binding site [nucleotide binding]
393126002774	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
393126002775	active site
393126002776	catalytic site [active]
393126002777	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
393126002778	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393126002779	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
393126002780	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
393126002781	Uncharacterized conserved protein [Function unknown]; Region: COG0398
393126002782	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393126002783	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
393126002784	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
393126002785	Ligand binding site; other site
393126002786	Putative Catalytic site; other site
393126002787	DXD motif; other site
393126002788	epoxyqueuosine reductase; Region: TIGR00276
393126002789	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
393126002790	A new structural DNA glycosylase; Region: AlkD_like; cl11434
393126002791	active site
393126002792	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
393126002793	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393126002794	dimer interface [polypeptide binding]; other site
393126002795	FMN binding site [chemical binding]; other site
393126002796	NADPH bind site [chemical binding]; other site
393126002797	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393126002798	Low molecular weight phosphatase family; Region: LMWPc; cd00115
393126002799	active site
393126002800	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
393126002801	HSP90 family protein; Provisional; Region: PRK14083
393126002802	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126002803	ATP binding site [chemical binding]; other site
393126002804	Mg2+ binding site [ion binding]; other site
393126002805	G-X-G motif; other site
393126002806	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
393126002807	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
393126002808	dimerization interface [polypeptide binding]; other site
393126002809	DPS ferroxidase diiron center [ion binding]; other site
393126002810	ion pore; other site
393126002811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
393126002812	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
393126002813	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126002814	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
393126002815	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
393126002816	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
393126002817	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
393126002818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002819	putative substrate translocation pore; other site
393126002820	Transcriptional regulators [Transcription]; Region: FadR; COG2186
393126002821	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002822	DNA-binding site [nucleotide binding]; DNA binding site
393126002823	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
393126002824	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393126002825	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393126002826	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
393126002827	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
393126002828	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
393126002829	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
393126002830	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
393126002831	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
393126002832	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
393126002833	active site
393126002834	dimer interface [polypeptide binding]; other site
393126002835	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393126002836	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393126002837	active site
393126002838	trimer interface [polypeptide binding]; other site
393126002839	allosteric site; other site
393126002840	active site lid [active]
393126002841	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393126002842	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126002843	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126002844	DNA-binding site [nucleotide binding]; DNA binding site
393126002845	UTRA domain; Region: UTRA; pfam07702
393126002846	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
393126002847	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
393126002848	Mg++ binding site [ion binding]; other site
393126002849	putative catalytic motif [active]
393126002850	substrate binding site [chemical binding]; other site
393126002851	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
393126002852	Peptidase family U32; Region: Peptidase_U32; pfam01136
393126002853	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
393126002854	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393126002855	Peptidase family U32; Region: Peptidase_U32; pfam01136
393126002856	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
393126002857	heat shock protein HtpX; Provisional; Region: PRK04897
393126002858	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
393126002859	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
393126002860	catalytic residues [active]
393126002861	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
393126002862	putative active site [active]
393126002863	putative metal binding residues [ion binding]; other site
393126002864	signature motif; other site
393126002865	putative triphosphate binding site [ion binding]; other site
393126002866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126002867	TPR motif; other site
393126002868	binding surface
393126002869	TPR repeat; Region: TPR_11; pfam13414
393126002870	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393126002871	synthetase active site [active]
393126002872	NTP binding site [chemical binding]; other site
393126002873	metal binding site [ion binding]; metal-binding site
393126002874	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
393126002875	ATP-NAD kinase; Region: NAD_kinase; pfam01513
393126002876	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393126002877	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393126002878	active site
393126002879	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
393126002880	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
393126002881	NAD binding site [chemical binding]; other site
393126002882	homotetramer interface [polypeptide binding]; other site
393126002883	homodimer interface [polypeptide binding]; other site
393126002884	substrate binding site [chemical binding]; other site
393126002885	active site
393126002886	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
393126002887	DltD N-terminal region; Region: DltD_N; pfam04915
393126002888	DltD central region; Region: DltD_M; pfam04918
393126002889	DltD C-terminal region; Region: DltD_C; pfam04914
393126002890	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
393126002891	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
393126002892	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
393126002893	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
393126002894	acyl-activating enzyme (AAE) consensus motif; other site
393126002895	AMP binding site [chemical binding]; other site
393126002896	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
393126002897	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126002898	active site
393126002899	dimer interface [polypeptide binding]; other site
393126002900	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126002901	Coenzyme A binding pocket [chemical binding]; other site
393126002902	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
393126002903	Putative esterase; Region: Esterase; pfam00756
393126002904	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
393126002905	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
393126002906	homodimer interface [polypeptide binding]; other site
393126002907	substrate-cofactor binding pocket; other site
393126002908	catalytic residue [active]
393126002909	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393126002910	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126002911	Walker A/P-loop; other site
393126002912	ATP binding site [chemical binding]; other site
393126002913	Q-loop/lid; other site
393126002914	ABC transporter signature motif; other site
393126002915	Walker B; other site
393126002916	D-loop; other site
393126002917	H-loop/switch region; other site
393126002918	ABC-2 type transporter; Region: ABC2_membrane; cl17235
393126002919	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393126002920	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126002921	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126002922	putative substrate translocation pore; other site
393126002923	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393126002924	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
393126002925	putative oligomer interface [polypeptide binding]; other site
393126002926	putative active site [active]
393126002927	metal binding site [ion binding]; metal-binding site
393126002928	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
393126002929	catalytic residues [active]
393126002930	dimer interface [polypeptide binding]; other site
393126002931	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
393126002932	LytTr DNA-binding domain; Region: LytTR; pfam04397
393126002933	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126002934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126002935	Walker A/P-loop; other site
393126002936	ATP binding site [chemical binding]; other site
393126002937	Q-loop/lid; other site
393126002938	ABC transporter signature motif; other site
393126002939	Walker B; other site
393126002940	D-loop; other site
393126002941	H-loop/switch region; other site
393126002942	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
393126002943	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393126002944	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
393126002945	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
393126002946	G1 box; other site
393126002947	putative GEF interaction site [polypeptide binding]; other site
393126002948	GTP/Mg2+ binding site [chemical binding]; other site
393126002949	Switch I region; other site
393126002950	G2 box; other site
393126002951	G3 box; other site
393126002952	Switch II region; other site
393126002953	G4 box; other site
393126002954	G5 box; other site
393126002955	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
393126002956	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126002957	MarR family; Region: MarR_2; cl17246
393126002958	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393126002959	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393126002960	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
393126002961	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
393126002962	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
393126002963	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
393126002964	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
393126002965	Acyltransferase family; Region: Acyl_transf_3; pfam01757
393126002966	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
393126002967	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393126002968	DNA binding site [nucleotide binding]
393126002969	active site
393126002970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126002971	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
393126002972	Walker A motif; other site
393126002973	ATP binding site [chemical binding]; other site
393126002974	Walker B motif; other site
393126002975	arginine finger; other site
393126002976	UvrB/uvrC motif; Region: UVR; pfam02151
393126002977	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126002978	Walker A motif; other site
393126002979	ATP binding site [chemical binding]; other site
393126002980	Walker B motif; other site
393126002981	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
393126002982	CAAX protease self-immunity; Region: Abi; pfam02517
393126002983	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
393126002984	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393126002985	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
393126002986	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
393126002987	dimerization domain swap beta strand [polypeptide binding]; other site
393126002988	regulatory protein interface [polypeptide binding]; other site
393126002989	active site
393126002990	regulatory phosphorylation site [posttranslational modification]; other site
393126002991	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
393126002992	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
393126002993	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393126002994	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
393126002995	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
393126002996	Uncharacterized conserved protein [Function unknown]; Region: COG1434
393126002997	putative active site [active]
393126002998	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
393126002999	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
393126003000	aminotransferase A; Validated; Region: PRK07683
393126003001	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126003002	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126003003	homodimer interface [polypeptide binding]; other site
393126003004	catalytic residue [active]
393126003005	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
393126003006	FOG: CBS domain [General function prediction only]; Region: COG0517
393126003007	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
393126003008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126003009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126003010	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393126003011	dimerization interface [polypeptide binding]; other site
393126003012	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
393126003013	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
393126003014	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393126003015	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393126003016	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393126003017	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
393126003018	metal binding site [ion binding]; metal-binding site
393126003019	putative dimer interface [polypeptide binding]; other site
393126003020	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
393126003021	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
393126003022	Mechanosensitive ion channel; Region: MS_channel; pfam00924
393126003023	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
393126003024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126003025	Walker A/P-loop; other site
393126003026	ATP binding site [chemical binding]; other site
393126003027	Q-loop/lid; other site
393126003028	ABC transporter signature motif; other site
393126003029	Walker B; other site
393126003030	D-loop; other site
393126003031	H-loop/switch region; other site
393126003032	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393126003033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126003034	dimer interface [polypeptide binding]; other site
393126003035	conserved gate region; other site
393126003036	putative PBP binding loops; other site
393126003037	ABC-ATPase subunit interface; other site
393126003038	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
393126003039	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393126003040	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393126003041	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
393126003042	HPr interaction site; other site
393126003043	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126003044	active site
393126003045	phosphorylation site [posttranslational modification]
393126003046	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
393126003047	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
393126003048	S1 domain; Region: S1_2; pfam13509
393126003049	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
393126003050	RNA binding site [nucleotide binding]; other site
393126003051	Predicted membrane protein [Function unknown]; Region: COG4758
393126003052	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
393126003053	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
393126003054	Histidine kinase; Region: HisKA_3; pfam07730
393126003055	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126003056	ATP binding site [chemical binding]; other site
393126003057	Mg2+ binding site [ion binding]; other site
393126003058	G-X-G motif; other site
393126003059	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
393126003060	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126003061	active site
393126003062	phosphorylation site [posttranslational modification]
393126003063	intermolecular recognition site; other site
393126003064	dimerization interface [polypeptide binding]; other site
393126003065	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
393126003066	DNA binding residues [nucleotide binding]
393126003067	dimerization interface [polypeptide binding]; other site
393126003068	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
393126003069	TrkA-N domain; Region: TrkA_N; pfam02254
393126003070	TrkA-C domain; Region: TrkA_C; pfam02080
393126003071	Predicted membrane protein [Function unknown]; Region: COG1289
393126003072	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
393126003073	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
393126003074	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
393126003075	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393126003076	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
393126003077	hypothetical protein; Provisional; Region: PRK13667
393126003078	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126003079	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126003080	active site
393126003081	motif I; other site
393126003082	motif II; other site
393126003083	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126003084	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126003085	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126003086	DNA binding site [nucleotide binding]
393126003087	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126003088	ligand binding site [chemical binding]; other site
393126003089	dimerization interface [polypeptide binding]; other site
393126003090	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
393126003091	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393126003092	trimer interface [polypeptide binding]; other site
393126003093	substrate binding site [chemical binding]; other site
393126003094	Mn binding site [ion binding]; other site
393126003095	transketolase; Reviewed; Region: PRK05899
393126003096	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393126003097	TPP-binding site [chemical binding]; other site
393126003098	dimer interface [polypeptide binding]; other site
393126003099	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
393126003100	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393126003101	PYR/PP interface [polypeptide binding]; other site
393126003102	dimer interface [polypeptide binding]; other site
393126003103	TPP binding site [chemical binding]; other site
393126003104	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126003105	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
393126003106	Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427
393126003107	N- and C-terminal domain interface [polypeptide binding]; other site
393126003108	active site
393126003109	MgATP binding site [chemical binding]; other site
393126003110	catalytic site [active]
393126003111	metal binding site [ion binding]; metal-binding site
393126003112	putative glycerol binding site [chemical binding]; other site
393126003113	putative homotetramer interface [polypeptide binding]; other site
393126003114	putative homodimer interface [polypeptide binding]; other site
393126003115	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393126003116	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126003117	active site turn [active]
393126003118	phosphorylation site [posttranslational modification]
393126003119	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126003120	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393126003121	HPr interaction site; other site
393126003122	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126003123	active site
393126003124	phosphorylation site [posttranslational modification]
393126003125	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
393126003126	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
393126003127	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
393126003128	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
393126003129	GTP binding site; other site
393126003130	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
393126003131	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
393126003132	Walker A/P-loop; other site
393126003133	ATP binding site [chemical binding]; other site
393126003134	Q-loop/lid; other site
393126003135	ABC transporter signature motif; other site
393126003136	Walker B; other site
393126003137	D-loop; other site
393126003138	H-loop/switch region; other site
393126003139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126003140	dimer interface [polypeptide binding]; other site
393126003141	conserved gate region; other site
393126003142	putative PBP binding loops; other site
393126003143	ABC-ATPase subunit interface; other site
393126003144	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
393126003145	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
393126003146	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
393126003147	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
393126003148	dimer interface [polypeptide binding]; other site
393126003149	putative functional site; other site
393126003150	putative MPT binding site; other site
393126003151	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
393126003152	Walker A motif; other site
393126003153	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
393126003154	MoaE homodimer interface [polypeptide binding]; other site
393126003155	MoaD interaction [polypeptide binding]; other site
393126003156	active site residues [active]
393126003157	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
393126003158	MoaE interaction surface [polypeptide binding]; other site
393126003159	MoeB interaction surface [polypeptide binding]; other site
393126003160	thiocarboxylated glycine; other site
393126003161	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
393126003162	trimer interface [polypeptide binding]; other site
393126003163	dimer interface [polypeptide binding]; other site
393126003164	putative active site [active]
393126003165	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
393126003166	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393126003167	FeS/SAM binding site; other site
393126003168	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
393126003169	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
393126003170	MPT binding site; other site
393126003171	trimer interface [polypeptide binding]; other site
393126003172	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
393126003173	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
393126003174	ATP binding site [chemical binding]; other site
393126003175	substrate interface [chemical binding]; other site
393126003176	Flavin Reductases; Region: FlaRed; cl00801
393126003177	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
393126003178	active site
393126003179	catalytic residues [active]
393126003180	metal binding site [ion binding]; metal-binding site
393126003181	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
393126003182	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
393126003183	TPP-binding site [chemical binding]; other site
393126003184	tetramer interface [polypeptide binding]; other site
393126003185	heterodimer interface [polypeptide binding]; other site
393126003186	phosphorylation loop region [posttranslational modification]
393126003187	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
393126003188	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
393126003189	alpha subunit interface [polypeptide binding]; other site
393126003190	TPP binding site [chemical binding]; other site
393126003191	heterodimer interface [polypeptide binding]; other site
393126003192	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126003193	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
393126003194	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393126003195	E3 interaction surface; other site
393126003196	lipoyl attachment site [posttranslational modification]; other site
393126003197	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393126003198	E3 interaction surface; other site
393126003199	lipoyl attachment site [posttranslational modification]; other site
393126003200	e3 binding domain; Region: E3_binding; pfam02817
393126003201	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
393126003202	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
393126003203	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393126003204	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126003205	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393126003206	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
393126003207	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
393126003208	NAD(P) binding site [chemical binding]; other site
393126003209	LDH/MDH dimer interface [polypeptide binding]; other site
393126003210	substrate binding site [chemical binding]; other site
393126003211	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476
393126003212	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
393126003213	Thioredoxin; Region: Thioredoxin_4; pfam13462
393126003214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126003215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126003216	active site
393126003217	phosphorylation site [posttranslational modification]
393126003218	intermolecular recognition site; other site
393126003219	dimerization interface [polypeptide binding]; other site
393126003220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126003221	DNA binding site [nucleotide binding]
393126003222	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393126003223	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126003224	dimerization interface [polypeptide binding]; other site
393126003225	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126003226	dimer interface [polypeptide binding]; other site
393126003227	phosphorylation site [posttranslational modification]
393126003228	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126003229	ATP binding site [chemical binding]; other site
393126003230	Mg2+ binding site [ion binding]; other site
393126003231	G-X-G motif; other site
393126003232	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126003233	FtsX-like permease family; Region: FtsX; pfam02687
393126003234	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126003235	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126003236	Walker A/P-loop; other site
393126003237	ATP binding site [chemical binding]; other site
393126003238	Q-loop/lid; other site
393126003239	ABC transporter signature motif; other site
393126003240	Walker B; other site
393126003241	D-loop; other site
393126003242	H-loop/switch region; other site
393126003243	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
393126003244	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393126003245	Cl binding site [ion binding]; other site
393126003246	oligomer interface [polypeptide binding]; other site
393126003247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
393126003248	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
393126003249	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
393126003250	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
393126003251	active site
393126003252	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
393126003253	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
393126003254	G1 box; other site
393126003255	putative GEF interaction site [polypeptide binding]; other site
393126003256	GTP/Mg2+ binding site [chemical binding]; other site
393126003257	Switch I region; other site
393126003258	G2 box; other site
393126003259	G3 box; other site
393126003260	Switch II region; other site
393126003261	G4 box; other site
393126003262	G5 box; other site
393126003263	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
393126003264	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
393126003265	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
393126003266	hypothetical protein; Provisional; Region: PRK13666
393126003267	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393126003268	pyruvate carboxylase; Reviewed; Region: PRK12999
393126003269	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393126003270	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
393126003271	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
393126003272	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
393126003273	active site
393126003274	catalytic residues [active]
393126003275	metal binding site [ion binding]; metal-binding site
393126003276	homodimer binding site [polypeptide binding]; other site
393126003277	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
393126003278	carboxyltransferase (CT) interaction site; other site
393126003279	biotinylation site [posttranslational modification]; other site
393126003280	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
393126003281	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
393126003282	putative binding site residues; other site
393126003283	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
393126003284	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393126003285	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
393126003286	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
393126003287	Walker A/P-loop; other site
393126003288	ATP binding site [chemical binding]; other site
393126003289	Q-loop/lid; other site
393126003290	ABC transporter signature motif; other site
393126003291	Walker B; other site
393126003292	D-loop; other site
393126003293	H-loop/switch region; other site
393126003294	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126003295	SH3-like domain; Region: SH3_8; pfam13457
393126003296	SH3-like domain; Region: SH3_8; pfam13457
393126003297	SH3-like domain; Region: SH3_8; pfam13457
393126003298	SH3-like domain; Region: SH3_8; pfam13457
393126003299	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393126003300	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
393126003301	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
393126003302	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
393126003303	active site
393126003304	tetramer interface; other site
393126003305	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
393126003306	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
393126003307	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
393126003308	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393126003309	active site
393126003310	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
393126003311	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
393126003312	substrate binding site; other site
393126003313	tetramer interface; other site
393126003314	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
393126003315	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
393126003316	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
393126003317	NAD binding site [chemical binding]; other site
393126003318	substrate binding site [chemical binding]; other site
393126003319	homodimer interface [polypeptide binding]; other site
393126003320	active site
393126003321	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
393126003322	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
393126003323	NADP binding site [chemical binding]; other site
393126003324	active site
393126003325	putative substrate binding site [chemical binding]; other site
393126003326	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393126003327	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
393126003328	substrate binding site; other site
393126003329	dimer interface; other site
393126003330	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
393126003331	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393126003332	putative NAD(P) binding site [chemical binding]; other site
393126003333	putative catalytic Zn binding site [ion binding]; other site
393126003334	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393126003335	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
393126003336	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
393126003337	active site
393126003338	putative glycosyl transferase; Provisional; Region: PRK10073
393126003339	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393126003340	active site
393126003341	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393126003342	active site
393126003343	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
393126003344	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
393126003345	active site
393126003346	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
393126003347	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
393126003348	homodimer interface [polypeptide binding]; other site
393126003349	NAD binding pocket [chemical binding]; other site
393126003350	ATP binding pocket [chemical binding]; other site
393126003351	Mg binding site [ion binding]; other site
393126003352	active-site loop [active]
393126003353	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393126003354	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
393126003355	active site
393126003356	P-loop; other site
393126003357	phosphorylation site [posttranslational modification]
393126003358	GMP synthase; Reviewed; Region: guaA; PRK00074
393126003359	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
393126003360	AMP/PPi binding site [chemical binding]; other site
393126003361	candidate oxyanion hole; other site
393126003362	catalytic triad [active]
393126003363	potential glutamine specificity residues [chemical binding]; other site
393126003364	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
393126003365	ATP Binding subdomain [chemical binding]; other site
393126003366	Dimerization subdomain; other site
393126003367	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003368	Helix-turn-helix domain; Region: HTH_18; pfam12833
393126003369	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003370	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
393126003371	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126003372	active site
393126003373	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
393126003374	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393126003375	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393126003376	MepB protein; Region: MepB; cl01985
393126003377	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
393126003378	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393126003379	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126003380	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126003381	Coenzyme A binding pocket [chemical binding]; other site
393126003382	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126003383	Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768
393126003384	DNA binding residues [nucleotide binding]
393126003385	drug binding residues [chemical binding]; other site
393126003386	dimer interface [polypeptide binding]; other site
393126003387	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
393126003388	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126003389	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
393126003390	Walker A/P-loop; other site
393126003391	ATP binding site [chemical binding]; other site
393126003392	Q-loop/lid; other site
393126003393	ABC transporter signature motif; other site
393126003394	Walker B; other site
393126003395	D-loop; other site
393126003396	H-loop/switch region; other site
393126003397	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126003398	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126003399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126003400	Walker A/P-loop; other site
393126003401	ATP binding site [chemical binding]; other site
393126003402	Q-loop/lid; other site
393126003403	ABC transporter signature motif; other site
393126003404	Walker B; other site
393126003405	D-loop; other site
393126003406	H-loop/switch region; other site
393126003407	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
393126003408	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126003409	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126003410	DNA binding residues [nucleotide binding]
393126003411	putative dimer interface [polypeptide binding]; other site
393126003412	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126003413	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393126003414	LRR adjacent; Region: LRR_adjacent; pfam08191
393126003415	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126003416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
393126003417	Clp protease; Region: CLP_protease; pfam00574
393126003418	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
393126003419	oligomer interface [polypeptide binding]; other site
393126003420	active site residues [active]
393126003421	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393126003422	dimer interface [polypeptide binding]; other site
393126003423	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126003424	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
393126003425	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
393126003426	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
393126003427	SLBB domain; Region: SLBB; pfam10531
393126003428	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
393126003429	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
393126003430	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003431	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
393126003432	putative hexamer interface [polypeptide binding]; other site
393126003433	putative hexagonal pore; other site
393126003434	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
393126003435	putative hexamer interface [polypeptide binding]; other site
393126003436	putative hexagonal pore; other site
393126003437	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
393126003438	putative hexamer interface [polypeptide binding]; other site
393126003439	putative hexagonal pore; other site
393126003440	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
393126003441	G1 box; other site
393126003442	GTP/Mg2+ binding site [chemical binding]; other site
393126003443	G2 box; other site
393126003444	Switch I region; other site
393126003445	G3 box; other site
393126003446	Switch II region; other site
393126003447	G4 box; other site
393126003448	G5 box; other site
393126003449	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
393126003450	homotrimer interface [polypeptide binding]; other site
393126003451	Walker A motif; other site
393126003452	GTP binding site [chemical binding]; other site
393126003453	Walker B motif; other site
393126003454	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
393126003455	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126003456	catalytic core [active]
393126003457	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
393126003458	Sensory domain found in PocR; Region: PocR; pfam10114
393126003459	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003460	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126003461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003462	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003463	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393126003464	Hexamer interface [polypeptide binding]; other site
393126003465	Hexagonal pore residue; other site
393126003466	propanediol utilization protein PduB; Provisional; Region: PRK15415
393126003467	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
393126003468	putative hexamer interface [polypeptide binding]; other site
393126003469	putative hexagonal pore; other site
393126003470	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
393126003471	putative hexamer interface [polypeptide binding]; other site
393126003472	putative hexagonal pore; other site
393126003473	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
393126003474	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
393126003475	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
393126003476	alpha-beta subunit interface [polypeptide binding]; other site
393126003477	alpha-gamma subunit interface [polypeptide binding]; other site
393126003478	active site
393126003479	substrate and K+ binding site; other site
393126003480	K+ binding site [ion binding]; other site
393126003481	cobalamin binding site [chemical binding]; other site
393126003482	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
393126003483	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
393126003484	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
393126003485	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
393126003486	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003487	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
393126003488	putative hexamer interface [polypeptide binding]; other site
393126003489	putative hexagonal pore; other site
393126003490	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003491	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393126003492	Hexamer interface [polypeptide binding]; other site
393126003493	Hexagonal pore residue; other site
393126003494	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
393126003495	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393126003496	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393126003497	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
393126003498	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126003499	nucleotide binding site [chemical binding]; other site
393126003500	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393126003501	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
393126003502	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
393126003503	Hexamer/Pentamer interface [polypeptide binding]; other site
393126003504	central pore; other site
393126003505	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
393126003506	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
393126003507	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
393126003508	putative catalytic cysteine [active]
393126003509	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
393126003510	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
393126003511	putative active site [active]
393126003512	metal binding site [ion binding]; metal-binding site
393126003513	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
393126003514	amphipathic channel; other site
393126003515	Asn-Pro-Ala signature motifs; other site
393126003516	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
393126003517	propionate/acetate kinase; Provisional; Region: PRK12379
393126003518	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
393126003519	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126003520	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126003521	homodimer interface [polypeptide binding]; other site
393126003522	catalytic residue [active]
393126003523	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
393126003524	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
393126003525	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
393126003526	putative active site [active]
393126003527	metal binding site [ion binding]; metal-binding site
393126003528	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
393126003529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126003530	active site
393126003531	phosphorylation site [posttranslational modification]
393126003532	intermolecular recognition site; other site
393126003533	dimerization interface [polypeptide binding]; other site
393126003534	ANTAR domain; Region: ANTAR; pfam03861
393126003535	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
393126003536	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
393126003537	Histidine kinase; Region: HisKA_2; pfam07568
393126003538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126003539	ATP binding site [chemical binding]; other site
393126003540	Mg2+ binding site [ion binding]; other site
393126003541	G-X-G motif; other site
393126003542	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
393126003543	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
393126003544	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
393126003545	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
393126003546	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
393126003547	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
393126003548	putative hexamer interface [polypeptide binding]; other site
393126003549	putative hexagonal pore; other site
393126003550	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
393126003551	putative hexamer interface [polypeptide binding]; other site
393126003552	putative hexagonal pore; other site
393126003553	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003554	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393126003555	Hexamer interface [polypeptide binding]; other site
393126003556	Hexagonal pore residue; other site
393126003557	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
393126003558	putative catalytic cysteine [active]
393126003559	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393126003560	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
393126003561	Hexamer interface [polypeptide binding]; other site
393126003562	Putative hexagonal pore residue; other site
393126003563	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
393126003564	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
393126003565	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393126003566	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393126003567	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
393126003568	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
393126003569	Hexamer/Pentamer interface [polypeptide binding]; other site
393126003570	central pore; other site
393126003571	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
393126003572	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
393126003573	putative hexamer interface [polypeptide binding]; other site
393126003574	putative hexagonal pore; other site
393126003575	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
393126003576	putative hexamer interface [polypeptide binding]; other site
393126003577	putative hexagonal pore; other site
393126003578	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
393126003579	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
393126003580	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
393126003581	hypothetical protein; Region: PHA01818
393126003582	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003583	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126003584	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126003585	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
393126003586	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
393126003587	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
393126003588	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
393126003589	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
393126003590	catalytic triad [active]
393126003591	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
393126003592	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
393126003593	Precorrin-8X methylmutase; Region: CbiC; pfam02570
393126003594	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
393126003595	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
393126003596	active site
393126003597	putative homodimer interface [polypeptide binding]; other site
393126003598	SAM binding site [chemical binding]; other site
393126003599	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
393126003600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126003601	S-adenosylmethionine binding site [chemical binding]; other site
393126003602	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
393126003603	active site
393126003604	SAM binding site [chemical binding]; other site
393126003605	homodimer interface [polypeptide binding]; other site
393126003606	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
393126003607	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
393126003608	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
393126003609	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
393126003610	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
393126003611	active site
393126003612	SAM binding site [chemical binding]; other site
393126003613	homodimer interface [polypeptide binding]; other site
393126003614	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
393126003615	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
393126003616	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
393126003617	active site
393126003618	SAM binding site [chemical binding]; other site
393126003619	homodimer interface [polypeptide binding]; other site
393126003620	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
393126003621	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
393126003622	active site
393126003623	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
393126003624	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
393126003625	active site
393126003626	C-terminal domain interface [polypeptide binding]; other site
393126003627	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
393126003628	active site
393126003629	N-terminal domain interface [polypeptide binding]; other site
393126003630	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
393126003631	active site
393126003632	SAM binding site [chemical binding]; other site
393126003633	homodimer interface [polypeptide binding]; other site
393126003634	cobalt transport protein CbiM; Validated; Region: PRK08319
393126003635	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
393126003636	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
393126003637	cobalt transport protein CbiQ; Provisional; Region: PRK15485
393126003638	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
393126003639	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393126003640	Walker A/P-loop; other site
393126003641	ATP binding site [chemical binding]; other site
393126003642	Q-loop/lid; other site
393126003643	ABC transporter signature motif; other site
393126003644	Walker B; other site
393126003645	D-loop; other site
393126003646	H-loop/switch region; other site
393126003647	cobyric acid synthase; Provisional; Region: PRK00784
393126003648	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393126003649	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393126003650	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
393126003651	catalytic triad [active]
393126003652	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
393126003653	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
393126003654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
393126003655	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
393126003656	AAA domain; Region: AAA_17; pfam13207
393126003657	Predicted transcriptional regulators [Transcription]; Region: COG1695
393126003658	Transcriptional regulator PadR-like family; Region: PadR; cl17335
393126003659	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
393126003660	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126003661	SH3-like domain; Region: SH3_8; pfam13457
393126003662	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126003663	SH3-like domain; Region: SH3_8; pfam13457
393126003664	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393126003665	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
393126003666	oligomer interface [polypeptide binding]; other site
393126003667	active site
393126003668	metal binding site [ion binding]; metal-binding site
393126003669	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
393126003670	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
393126003671	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
393126003672	Predicted transcriptional regulators [Transcription]; Region: COG1733
393126003673	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
393126003674	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
393126003675	phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468
393126003676	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
393126003677	dimer interface [polypeptide binding]; other site
393126003678	motif 1; other site
393126003679	active site
393126003680	motif 2; other site
393126003681	motif 3; other site
393126003682	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
393126003683	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
393126003684	putative tRNA-binding site [nucleotide binding]; other site
393126003685	B3/4 domain; Region: B3_4; pfam03483
393126003686	tRNA synthetase B5 domain; Region: B5; smart00874
393126003687	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
393126003688	dimer interface [polypeptide binding]; other site
393126003689	motif 1; other site
393126003690	motif 3; other site
393126003691	motif 2; other site
393126003692	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
393126003693	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126003694	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126003695	Walker A/P-loop; other site
393126003696	ATP binding site [chemical binding]; other site
393126003697	Q-loop/lid; other site
393126003698	ABC transporter signature motif; other site
393126003699	Walker B; other site
393126003700	D-loop; other site
393126003701	H-loop/switch region; other site
393126003702	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126003703	FtsX-like permease family; Region: FtsX; pfam02687
393126003704	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
393126003705	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126003706	FtsX-like permease family; Region: FtsX; pfam02687
393126003707	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126003708	MarR family; Region: MarR_2; pfam12802
393126003709	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
393126003710	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
393126003711	ligand binding site [chemical binding]; other site
393126003712	active site
393126003713	UGI interface [polypeptide binding]; other site
393126003714	catalytic site [active]
393126003715	ribonuclease HIII; Provisional; Region: PRK00996
393126003716	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
393126003717	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
393126003718	RNA/DNA hybrid binding site [nucleotide binding]; other site
393126003719	active site
393126003720	Cell division protein ZapA; Region: ZapA; cl01146
393126003721	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
393126003722	Colicin V production protein; Region: Colicin_V; pfam02674
393126003723	hypothetical protein; Provisional; Region: PRK08609
393126003724	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
393126003725	active site
393126003726	primer binding site [nucleotide binding]; other site
393126003727	NTP  binding site [chemical binding]; other site
393126003728	metal binding triad [ion binding]; metal-binding site
393126003729	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
393126003730	active site
393126003731	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
393126003732	MutS domain III; Region: MutS_III; pfam05192
393126003733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126003734	Walker A/P-loop; other site
393126003735	ATP binding site [chemical binding]; other site
393126003736	Q-loop/lid; other site
393126003737	ABC transporter signature motif; other site
393126003738	Walker B; other site
393126003739	D-loop; other site
393126003740	H-loop/switch region; other site
393126003741	Smr domain; Region: Smr; pfam01713
393126003742	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126003743	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393126003744	catalytic residues [active]
393126003745	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
393126003746	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
393126003747	GIY-YIG motif/motif A; other site
393126003748	active site
393126003749	catalytic site [active]
393126003750	putative DNA binding site [nucleotide binding]; other site
393126003751	metal binding site [ion binding]; metal-binding site
393126003752	UvrB/uvrC motif; Region: UVR; pfam02151
393126003753	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
393126003754	aspartate kinase; Reviewed; Region: PRK06635
393126003755	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
393126003756	putative nucleotide binding site [chemical binding]; other site
393126003757	putative catalytic residues [active]
393126003758	putative Mg ion binding site [ion binding]; other site
393126003759	putative aspartate binding site [chemical binding]; other site
393126003760	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
393126003761	putative allosteric regulatory site; other site
393126003762	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
393126003763	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
393126003764	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
393126003765	ribonuclease PH; Reviewed; Region: rph; PRK00173
393126003766	Ribonuclease PH; Region: RNase_PH_bact; cd11362
393126003767	hexamer interface [polypeptide binding]; other site
393126003768	active site
393126003769	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
393126003770	active site
393126003771	dimerization interface [polypeptide binding]; other site
393126003772	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
393126003773	active site
393126003774	metal binding site [ion binding]; metal-binding site
393126003775	homotetramer interface [polypeptide binding]; other site
393126003776	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
393126003777	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
393126003778	Int/Topo IB signature motif; other site
393126003779	Domain of unknown function (DUF955); Region: DUF955; pfam06114
393126003780	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126003781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126003782	non-specific DNA binding site [nucleotide binding]; other site
393126003783	salt bridge; other site
393126003784	sequence-specific DNA binding site [nucleotide binding]; other site
393126003785	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
393126003786	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126003787	salt bridge; other site
393126003788	non-specific DNA binding site [nucleotide binding]; other site
393126003789	sequence-specific DNA binding site [nucleotide binding]; other site
393126003790	Methyltransferase domain; Region: Methyltransf_25; pfam13649
393126003791	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393126003792	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126003793	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126003794	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
393126003795	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
393126003796	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
393126003797	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
393126003798	AAA domain; Region: AAA_24; pfam13479
393126003799	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126003800	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
393126003801	putative Mg++ binding site [ion binding]; other site
393126003802	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126003803	nucleotide binding region [chemical binding]; other site
393126003804	ATP-binding site [chemical binding]; other site
393126003805	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
393126003806	Protein of unknown function (DUF669); Region: DUF669; pfam05037
393126003807	Uncharacterized conserved protein [Function unknown]; Region: COG4983
393126003808	D5 N terminal like; Region: D5_N; pfam08706
393126003809	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
393126003810	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
393126003811	VRR-NUC domain; Region: VRR_NUC; pfam08774
393126003812	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
393126003813	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393126003814	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126003815	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126003816	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
393126003817	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
393126003818	putative active site [active]
393126003819	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
393126003820	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
393126003821	active site
393126003822	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
393126003823	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
393126003824	Phage portal protein; Region: Phage_portal; pfam04860
393126003825	Phage-related protein [Function unknown]; Region: COG4695; cl01923
393126003826	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
393126003827	oligomer interface [polypeptide binding]; other site
393126003828	active site residues [active]
393126003829	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
393126003830	Phage capsid family; Region: Phage_capsid; pfam05065
393126003831	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
393126003832	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
393126003833	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
393126003834	N-acetyl-D-glucosamine binding site [chemical binding]; other site
393126003835	catalytic residue [active]
393126003836	Phage tail protein; Region: Sipho_tail; cl17486
393126003837	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
393126003838	Bacteriophage holin; Region: Phage_holin_1; pfam04531
393126003839	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
393126003840	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393126003841	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393126003842	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
393126003843	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
393126003844	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
393126003845	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
393126003846	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393126003847	dimer interface [polypeptide binding]; other site
393126003848	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126003849	catalytic core [active]
393126003850	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
393126003851	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393126003852	ATP binding site [chemical binding]; other site
393126003853	Mg++ binding site [ion binding]; other site
393126003854	motif III; other site
393126003855	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126003856	nucleotide binding region [chemical binding]; other site
393126003857	ATP-binding site [chemical binding]; other site
393126003858	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
393126003859	RNA binding site [nucleotide binding]; other site
393126003860	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393126003861	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
393126003862	putative active site [active]
393126003863	nucleotide binding site [chemical binding]; other site
393126003864	nudix motif; other site
393126003865	putative metal binding site [ion binding]; other site
393126003866	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126003867	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126003868	putative substrate translocation pore; other site
393126003869	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126003870	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126003871	ligand binding site [chemical binding]; other site
393126003872	flexible hinge region; other site
393126003873	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126003874	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393126003875	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126003876	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126003877	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
393126003878	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126003879	DNA-binding site [nucleotide binding]; DNA binding site
393126003880	UTRA domain; Region: UTRA; pfam07702
393126003881	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393126003882	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393126003883	Ca binding site [ion binding]; other site
393126003884	active site
393126003885	catalytic site [active]
393126003886	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
393126003887	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126003888	active site turn [active]
393126003889	phosphorylation site [posttranslational modification]
393126003890	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126003891	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
393126003892	nudix motif; other site
393126003893	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
393126003894	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393126003895	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
393126003896	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
393126003897	putative catalytic cysteine [active]
393126003898	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
393126003899	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
393126003900	nucleotide binding site [chemical binding]; other site
393126003901	homotetrameric interface [polypeptide binding]; other site
393126003902	putative phosphate binding site [ion binding]; other site
393126003903	putative allosteric binding site; other site
393126003904	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
393126003905	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
393126003906	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126003907	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126003908	non-specific DNA binding site [nucleotide binding]; other site
393126003909	salt bridge; other site
393126003910	sequence-specific DNA binding site [nucleotide binding]; other site
393126003911	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126003912	non-specific DNA binding site [nucleotide binding]; other site
393126003913	salt bridge; other site
393126003914	sequence-specific DNA binding site [nucleotide binding]; other site
393126003915	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
393126003916	active site
393126003917	trigger factor; Provisional; Region: tig; PRK01490
393126003918	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
393126003919	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
393126003920	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
393126003921	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
393126003922	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126003923	Walker A motif; other site
393126003924	ATP binding site [chemical binding]; other site
393126003925	Walker B motif; other site
393126003926	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393126003927	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
393126003928	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393126003929	Catalytic site [active]
393126003930	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393126003931	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
393126003932	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393126003933	Catalytic site [active]
393126003934	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
393126003935	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
393126003936	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393126003937	Catalytic site [active]
393126003938	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393126003939	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
393126003940	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
393126003941	GTP/Mg2+ binding site [chemical binding]; other site
393126003942	G4 box; other site
393126003943	G5 box; other site
393126003944	G1 box; other site
393126003945	Switch I region; other site
393126003946	G2 box; other site
393126003947	G3 box; other site
393126003948	Switch II region; other site
393126003949	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
393126003950	RNA/DNA hybrid binding site [nucleotide binding]; other site
393126003951	active site
393126003952	DNA protecting protein DprA; Region: dprA; TIGR00732
393126003953	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
393126003954	DNA topoisomerase I; Validated; Region: PRK05582
393126003955	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
393126003956	active site
393126003957	interdomain interaction site; other site
393126003958	putative metal-binding site [ion binding]; other site
393126003959	nucleotide binding site [chemical binding]; other site
393126003960	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
393126003961	domain I; other site
393126003962	DNA binding groove [nucleotide binding]
393126003963	phosphate binding site [ion binding]; other site
393126003964	domain II; other site
393126003965	domain III; other site
393126003966	nucleotide binding site [chemical binding]; other site
393126003967	catalytic site [active]
393126003968	domain IV; other site
393126003969	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
393126003970	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
393126003971	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
393126003972	Glucose inhibited division protein A; Region: GIDA; pfam01134
393126003973	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
393126003974	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
393126003975	active site
393126003976	DNA binding site [nucleotide binding]
393126003977	Int/Topo IB signature motif; other site
393126003978	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
393126003979	active site
393126003980	HslU subunit interaction site [polypeptide binding]; other site
393126003981	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
393126003982	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126003983	Walker A motif; other site
393126003984	ATP binding site [chemical binding]; other site
393126003985	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
393126003986	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393126003987	transcriptional repressor CodY; Validated; Region: PRK04158
393126003988	CodY GAF-like domain; Region: CodY; pfam06018
393126003989	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
393126003990	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
393126003991	active site
393126003992	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
393126003993	active site
393126003994	catalytic residues [active]
393126003995	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
393126003996	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
393126003997	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
393126003998	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126003999	Mg2+ binding site [ion binding]; other site
393126004000	G-X-G motif; other site
393126004001	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
393126004002	anchoring element; other site
393126004003	dimer interface [polypeptide binding]; other site
393126004004	ATP binding site [chemical binding]; other site
393126004005	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
393126004006	active site
393126004007	putative metal-binding site [ion binding]; other site
393126004008	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
393126004009	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
393126004010	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
393126004011	CAP-like domain; other site
393126004012	active site
393126004013	primary dimer interface [polypeptide binding]; other site
393126004014	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393126004015	S-ribosylhomocysteinase; Provisional; Region: PRK02260
393126004016	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126004017	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126004018	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
393126004019	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
393126004020	catalytic triad [active]
393126004021	catalytic triad [active]
393126004022	oxyanion hole [active]
393126004023	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
393126004024	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
393126004025	active site
393126004026	catalytic site [active]
393126004027	metal binding site [ion binding]; metal-binding site
393126004028	dimer interface [polypeptide binding]; other site
393126004029	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
393126004030	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
393126004031	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
393126004032	bacterial Hfq-like; Region: Hfq; cd01716
393126004033	hexamer interface [polypeptide binding]; other site
393126004034	Sm1 motif; other site
393126004035	RNA binding site [nucleotide binding]; other site
393126004036	Sm2 motif; other site
393126004037	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
393126004038	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
393126004039	HflX GTPase family; Region: HflX; cd01878
393126004040	G1 box; other site
393126004041	GTP/Mg2+ binding site [chemical binding]; other site
393126004042	Switch I region; other site
393126004043	G2 box; other site
393126004044	G3 box; other site
393126004045	Switch II region; other site
393126004046	G4 box; other site
393126004047	G5 box; other site
393126004048	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
393126004049	Aluminium resistance protein; Region: Alum_res; pfam06838
393126004050	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
393126004051	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393126004052	DNA binding residues [nucleotide binding]
393126004053	putative dimer interface [polypeptide binding]; other site
393126004054	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
393126004055	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
393126004056	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
393126004057	arsenical pump membrane protein; Provisional; Region: PRK15445
393126004058	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
393126004059	transmembrane helices; other site
393126004060	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
393126004061	LexA repressor; Validated; Region: PRK00215
393126004062	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126004063	putative DNA binding site [nucleotide binding]; other site
393126004064	putative Zn2+ binding site [ion binding]; other site
393126004065	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
393126004066	Catalytic site [active]
393126004067	cell division suppressor protein YneA; Provisional; Region: PRK14125
393126004068	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
393126004069	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
393126004070	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393126004071	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393126004072	TPP-binding site [chemical binding]; other site
393126004073	dimer interface [polypeptide binding]; other site
393126004074	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393126004075	PYR/PP interface [polypeptide binding]; other site
393126004076	dimer interface [polypeptide binding]; other site
393126004077	TPP binding site [chemical binding]; other site
393126004078	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126004079	hypothetical protein; Provisional; Region: PRK01844
393126004080	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
393126004081	Protein of unknown function (DUF970); Region: DUF970; cl17525
393126004082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393126004083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126004084	S-adenosylmethionine binding site [chemical binding]; other site
393126004085	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
393126004086	ParB-like nuclease domain; Region: ParBc; pfam02195
393126004087	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
393126004088	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
393126004089	Active Sites [active]
393126004090	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
393126004091	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393126004092	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
393126004093	putative nucleotide binding site [chemical binding]; other site
393126004094	uridine monophosphate binding site [chemical binding]; other site
393126004095	homohexameric interface [polypeptide binding]; other site
393126004096	ribosome recycling factor; Reviewed; Region: frr; PRK00083
393126004097	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
393126004098	hinge region; other site
393126004099	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
393126004100	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
393126004101	putative FPP binding hydrophobic cleft; other site
393126004102	dimer interface [polypeptide binding]; other site
393126004103	putative IPP diphosphate binding site; other site
393126004104	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
393126004105	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
393126004106	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
393126004107	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
393126004108	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
393126004109	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
393126004110	RIP metalloprotease RseP; Region: TIGR00054
393126004111	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
393126004112	active site
393126004113	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
393126004114	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
393126004115	protein binding site [polypeptide binding]; other site
393126004116	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
393126004117	putative substrate binding region [chemical binding]; other site
393126004118	prolyl-tRNA synthetase; Provisional; Region: PRK09194
393126004119	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
393126004120	dimer interface [polypeptide binding]; other site
393126004121	motif 1; other site
393126004122	active site
393126004123	motif 2; other site
393126004124	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
393126004125	putative deacylase active site [active]
393126004126	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
393126004127	active site
393126004128	motif 3; other site
393126004129	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
393126004130	anticodon binding site; other site
393126004131	DNA polymerase III PolC; Validated; Region: polC; PRK00448
393126004132	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
393126004133	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
393126004134	generic binding surface II; other site
393126004135	generic binding surface I; other site
393126004136	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
393126004137	active site
393126004138	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
393126004139	active site
393126004140	catalytic site [active]
393126004141	substrate binding site [chemical binding]; other site
393126004142	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
393126004143	ribosome maturation protein RimP; Reviewed; Region: PRK00092
393126004144	Sm and related proteins; Region: Sm_like; cl00259
393126004145	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
393126004146	putative oligomer interface [polypeptide binding]; other site
393126004147	putative RNA binding site [nucleotide binding]; other site
393126004148	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
393126004149	NusA N-terminal domain; Region: NusA_N; pfam08529
393126004150	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
393126004151	RNA binding site [nucleotide binding]; other site
393126004152	homodimer interface [polypeptide binding]; other site
393126004153	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
393126004154	G-X-X-G motif; other site
393126004155	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
393126004156	G-X-X-G motif; other site
393126004157	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
393126004158	putative RNA binding cleft [nucleotide binding]; other site
393126004159	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
393126004160	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
393126004161	translation initiation factor IF-2; Region: IF-2; TIGR00487
393126004162	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
393126004163	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
393126004164	G1 box; other site
393126004165	putative GEF interaction site [polypeptide binding]; other site
393126004166	GTP/Mg2+ binding site [chemical binding]; other site
393126004167	Switch I region; other site
393126004168	G2 box; other site
393126004169	G3 box; other site
393126004170	Switch II region; other site
393126004171	G4 box; other site
393126004172	G5 box; other site
393126004173	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
393126004174	Translation-initiation factor 2; Region: IF-2; pfam11987
393126004175	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
393126004176	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
393126004177	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
393126004178	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
393126004179	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
393126004180	RNA binding site [nucleotide binding]; other site
393126004181	active site
393126004182	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
393126004183	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
393126004184	active site
393126004185	Riboflavin kinase; Region: Flavokinase; smart00904
393126004186	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
393126004187	16S/18S rRNA binding site [nucleotide binding]; other site
393126004188	S13e-L30e interaction site [polypeptide binding]; other site
393126004189	25S rRNA binding site [nucleotide binding]; other site
393126004190	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
393126004191	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
393126004192	RNase E interface [polypeptide binding]; other site
393126004193	trimer interface [polypeptide binding]; other site
393126004194	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
393126004195	RNase E interface [polypeptide binding]; other site
393126004196	trimer interface [polypeptide binding]; other site
393126004197	active site
393126004198	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
393126004199	putative nucleic acid binding region [nucleotide binding]; other site
393126004200	G-X-X-G motif; other site
393126004201	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
393126004202	RNA binding site [nucleotide binding]; other site
393126004203	domain interface; other site
393126004204	GTPase RsgA; Reviewed; Region: PRK01889
393126004205	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
393126004206	RNA binding site [nucleotide binding]; other site
393126004207	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
393126004208	GTPase/Zn-binding domain interface [polypeptide binding]; other site
393126004209	GTP/Mg2+ binding site [chemical binding]; other site
393126004210	G4 box; other site
393126004211	G5 box; other site
393126004212	G1 box; other site
393126004213	Switch I region; other site
393126004214	G2 box; other site
393126004215	G3 box; other site
393126004216	Switch II region; other site
393126004217	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
393126004218	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
393126004219	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
393126004220	Rhomboid family; Region: Rhomboid; pfam01694
393126004221	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126004222	TPR motif; other site
393126004223	TPR repeat; Region: TPR_11; pfam13414
393126004224	binding surface
393126004225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
393126004226	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
393126004227	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126004228	nucleotide binding site [chemical binding]; other site
393126004229	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
393126004230	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
393126004231	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
393126004232	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
393126004233	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
393126004234	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
393126004235	Type II/IV secretion system protein; Region: T2SE; pfam00437
393126004236	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393126004237	Walker A motif; other site
393126004238	ATP binding site [chemical binding]; other site
393126004239	Walker B motif; other site
393126004240	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
393126004241	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
393126004242	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
393126004243	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
393126004244	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
393126004245	tetramer interface [polypeptide binding]; other site
393126004246	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126004247	catalytic residue [active]
393126004248	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
393126004249	tetramer interface [polypeptide binding]; other site
393126004250	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126004251	catalytic residue [active]
393126004252	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
393126004253	active site residue [active]
393126004254	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
393126004255	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
393126004256	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
393126004257	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
393126004258	active site
393126004259	elongation factor P; Validated; Region: PRK00529
393126004260	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
393126004261	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
393126004262	RNA binding site [nucleotide binding]; other site
393126004263	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
393126004264	RNA binding site [nucleotide binding]; other site
393126004265	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
393126004266	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
393126004267	carboxyltransferase (CT) interaction site; other site
393126004268	biotinylation site [posttranslational modification]; other site
393126004269	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
393126004270	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393126004271	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393126004272	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
393126004273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
393126004274	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
393126004275	putative RNA binding site [nucleotide binding]; other site
393126004276	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
393126004277	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
393126004278	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
393126004279	homodimer interface [polypeptide binding]; other site
393126004280	NADP binding site [chemical binding]; other site
393126004281	substrate binding site [chemical binding]; other site
393126004282	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
393126004283	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
393126004284	generic binding surface II; other site
393126004285	generic binding surface I; other site
393126004286	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
393126004287	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393126004288	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393126004289	substrate binding pocket [chemical binding]; other site
393126004290	chain length determination region; other site
393126004291	substrate-Mg2+ binding site; other site
393126004292	catalytic residues [active]
393126004293	aspartate-rich region 1; other site
393126004294	active site lid residues [active]
393126004295	aspartate-rich region 2; other site
393126004296	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393126004297	DNA-binding site [nucleotide binding]; DNA binding site
393126004298	RNA-binding motif; other site
393126004299	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
393126004300	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
393126004301	TPP-binding site; other site
393126004302	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393126004303	PYR/PP interface [polypeptide binding]; other site
393126004304	dimer interface [polypeptide binding]; other site
393126004305	TPP binding site [chemical binding]; other site
393126004306	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126004307	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
393126004308	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126004309	RNA binding surface [nucleotide binding]; other site
393126004310	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
393126004311	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
393126004312	arginine repressor; Provisional; Region: PRK04280
393126004313	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
393126004314	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
393126004315	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
393126004316	Walker A/P-loop; other site
393126004317	ATP binding site [chemical binding]; other site
393126004318	Q-loop/lid; other site
393126004319	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
393126004320	ABC transporter signature motif; other site
393126004321	Walker B; other site
393126004322	D-loop; other site
393126004323	H-loop/switch region; other site
393126004324	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
393126004325	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126004326	nucleotide binding site [chemical binding]; other site
393126004327	Acetokinase family; Region: Acetate_kinase; cl17229
393126004328	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
393126004329	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126004330	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393126004331	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
393126004332	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
393126004333	tetramer interface [polypeptide binding]; other site
393126004334	TPP-binding site [chemical binding]; other site
393126004335	heterodimer interface [polypeptide binding]; other site
393126004336	phosphorylation loop region [posttranslational modification]
393126004337	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
393126004338	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
393126004339	alpha subunit interface [polypeptide binding]; other site
393126004340	TPP binding site [chemical binding]; other site
393126004341	heterodimer interface [polypeptide binding]; other site
393126004342	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393126004343	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
393126004344	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393126004345	E3 interaction surface; other site
393126004346	lipoyl attachment site [posttranslational modification]; other site
393126004347	e3 binding domain; Region: E3_binding; pfam02817
393126004348	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
393126004349	peptidase T-like protein; Region: PepT-like; TIGR01883
393126004350	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
393126004351	metal binding site [ion binding]; metal-binding site
393126004352	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
393126004353	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
393126004354	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
393126004355	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126004356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126004357	active site
393126004358	phosphorylation site [posttranslational modification]
393126004359	intermolecular recognition site; other site
393126004360	dimerization interface [polypeptide binding]; other site
393126004361	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126004362	DNA binding site [nucleotide binding]
393126004363	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393126004364	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126004365	dimerization interface [polypeptide binding]; other site
393126004366	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126004367	dimer interface [polypeptide binding]; other site
393126004368	phosphorylation site [posttranslational modification]
393126004369	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126004370	ATP binding site [chemical binding]; other site
393126004371	Mg2+ binding site [ion binding]; other site
393126004372	G-X-G motif; other site
393126004373	OxaA-like protein precursor; Validated; Region: PRK01622
393126004374	acylphosphatase; Provisional; Region: PRK14443
393126004375	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
393126004376	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
393126004377	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
393126004378	homotetramer interface [polypeptide binding]; other site
393126004379	FMN binding site [chemical binding]; other site
393126004380	homodimer contacts [polypeptide binding]; other site
393126004381	putative active site [active]
393126004382	putative substrate binding site [chemical binding]; other site
393126004383	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
393126004384	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
393126004385	active site residue [active]
393126004386	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
393126004387	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393126004388	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126004389	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126004390	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
393126004391	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
393126004392	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393126004393	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
393126004394	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
393126004395	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
393126004396	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
393126004397	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
393126004398	ligand binding site [chemical binding]; other site
393126004399	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
393126004400	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
393126004401	Walker A/P-loop; other site
393126004402	ATP binding site [chemical binding]; other site
393126004403	Q-loop/lid; other site
393126004404	ABC transporter signature motif; other site
393126004405	Walker B; other site
393126004406	D-loop; other site
393126004407	H-loop/switch region; other site
393126004408	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
393126004409	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
393126004410	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
393126004411	TM-ABC transporter signature motif; other site
393126004412	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
393126004413	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
393126004414	TM-ABC transporter signature motif; other site
393126004415	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
393126004416	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
393126004417	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
393126004418	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
393126004419	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
393126004420	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
393126004421	classical (c) SDRs; Region: SDR_c; cd05233
393126004422	NAD(P) binding site [chemical binding]; other site
393126004423	active site
393126004424	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
393126004425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126004426	non-specific DNA binding site [nucleotide binding]; other site
393126004427	salt bridge; other site
393126004428	sequence-specific DNA binding site [nucleotide binding]; other site
393126004429	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
393126004430	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
393126004431	competence damage-inducible protein A; Provisional; Region: PRK00549
393126004432	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
393126004433	putative MPT binding site; other site
393126004434	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
393126004435	recombinase A; Provisional; Region: recA; PRK09354
393126004436	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
393126004437	hexamer interface [polypeptide binding]; other site
393126004438	Walker A motif; other site
393126004439	ATP binding site [chemical binding]; other site
393126004440	Walker B motif; other site
393126004441	phosphodiesterase; Provisional; Region: PRK12704
393126004442	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126004443	Zn2+ binding site [ion binding]; other site
393126004444	Mg2+ binding site [ion binding]; other site
393126004445	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
393126004446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126004447	Coenzyme A binding pocket [chemical binding]; other site
393126004448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393126004449	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
393126004450	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393126004451	putative active site [active]
393126004452	metal binding site [ion binding]; metal-binding site
393126004453	homodimer binding site [polypeptide binding]; other site
393126004454	Predicted membrane protein [Function unknown]; Region: COG4550
393126004455	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
393126004456	MutS domain I; Region: MutS_I; pfam01624
393126004457	MutS domain II; Region: MutS_II; pfam05188
393126004458	MutS domain III; Region: MutS_III; pfam05192
393126004459	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
393126004460	Walker A/P-loop; other site
393126004461	ATP binding site [chemical binding]; other site
393126004462	Q-loop/lid; other site
393126004463	ABC transporter signature motif; other site
393126004464	Walker B; other site
393126004465	D-loop; other site
393126004466	H-loop/switch region; other site
393126004467	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
393126004468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126004469	ATP binding site [chemical binding]; other site
393126004470	Mg2+ binding site [ion binding]; other site
393126004471	G-X-G motif; other site
393126004472	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
393126004473	ATP binding site [chemical binding]; other site
393126004474	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
393126004475	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
393126004476	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
393126004477	Pyruvate formate lyase 1; Region: PFL1; cd01678
393126004478	coenzyme A binding site [chemical binding]; other site
393126004479	active site
393126004480	catalytic residues [active]
393126004481	glycine loop; other site
393126004482	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
393126004483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393126004484	FeS/SAM binding site; other site
393126004485	Predicted transcriptional regulators [Transcription]; Region: COG1695
393126004486	Transcriptional regulator PadR-like family; Region: PadR; cl17335
393126004487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126004488	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126004489	putative substrate translocation pore; other site
393126004490	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126004491	non-specific DNA binding site [nucleotide binding]; other site
393126004492	salt bridge; other site
393126004493	sequence-specific DNA binding site [nucleotide binding]; other site
393126004494	topology modulation protein; Provisional; Region: PRK07261
393126004495	AAA domain; Region: AAA_17; pfam13207
393126004496	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126004497	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126004498	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126004499	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126004500	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
393126004501	dimer interface [polypeptide binding]; other site
393126004502	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
393126004503	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
393126004504	dimer interface [polypeptide binding]; other site
393126004505	active site
393126004506	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
393126004507	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
393126004508	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126004509	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
393126004510	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
393126004511	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393126004512	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393126004513	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
393126004514	FAD binding domain; Region: FAD_binding_4; pfam01565
393126004515	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
393126004516	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
393126004517	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
393126004518	Walker A/P-loop; other site
393126004519	ATP binding site [chemical binding]; other site
393126004520	Q-loop/lid; other site
393126004521	ABC transporter signature motif; other site
393126004522	Walker B; other site
393126004523	D-loop; other site
393126004524	H-loop/switch region; other site
393126004525	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393126004526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126004527	dimer interface [polypeptide binding]; other site
393126004528	conserved gate region; other site
393126004529	ABC-ATPase subunit interface; other site
393126004530	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
393126004531	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
393126004532	manganese transport protein MntH; Reviewed; Region: PRK00701
393126004533	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
393126004534	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126004535	dimer interface [polypeptide binding]; other site
393126004536	conserved gate region; other site
393126004537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
393126004538	ABC-ATPase subunit interface; other site
393126004539	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393126004540	LysR substrate binding domain; Region: LysR_substrate; pfam03466
393126004541	dimerization interface [polypeptide binding]; other site
393126004542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126004543	dimer interface [polypeptide binding]; other site
393126004544	conserved gate region; other site
393126004545	putative PBP binding loops; other site
393126004546	ABC-ATPase subunit interface; other site
393126004547	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
393126004548	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
393126004549	Walker A/P-loop; other site
393126004550	ATP binding site [chemical binding]; other site
393126004551	Q-loop/lid; other site
393126004552	ABC transporter signature motif; other site
393126004553	Walker B; other site
393126004554	D-loop; other site
393126004555	H-loop/switch region; other site
393126004556	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
393126004557	Predicted membrane protein [Function unknown]; Region: COG3859
393126004558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
393126004559	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
393126004560	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126004561	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126004562	ABC transporter; Region: ABC_tran_2; pfam12848
393126004563	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126004564	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
393126004565	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126004566	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126004567	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393126004568	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
393126004569	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126004570	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
393126004571	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
393126004572	dihydrodipicolinate synthase; Region: dapA; TIGR00674
393126004573	dimer interface [polypeptide binding]; other site
393126004574	active site
393126004575	catalytic residue [active]
393126004576	aspartate kinase I; Reviewed; Region: PRK08210
393126004577	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
393126004578	nucleotide binding site [chemical binding]; other site
393126004579	substrate binding site [chemical binding]; other site
393126004580	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
393126004581	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
393126004582	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
393126004583	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
393126004584	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
393126004585	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393126004586	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393126004587	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
393126004588	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
393126004589	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
393126004590	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
393126004591	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
393126004592	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
393126004593	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
393126004594	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
393126004595	Predicted membrane protein [Function unknown]; Region: COG4392
393126004596	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
393126004597	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
393126004598	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393126004599	metal binding site 2 [ion binding]; metal-binding site
393126004600	putative DNA binding helix; other site
393126004601	metal binding site 1 [ion binding]; metal-binding site
393126004602	dimer interface [polypeptide binding]; other site
393126004603	structural Zn2+ binding site [ion binding]; other site
393126004604	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393126004605	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126004606	ABC-ATPase subunit  interface; other site
393126004607	dimer interface [polypeptide binding]; other site
393126004608	putative PBP binding regions; other site
393126004609	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
393126004610	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393126004611	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
393126004612	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393126004613	DHHA2 domain; Region: DHHA2; pfam02833
393126004614	endonuclease IV; Provisional; Region: PRK01060
393126004615	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
393126004616	AP (apurinic/apyrimidinic) site pocket; other site
393126004617	DNA interaction; other site
393126004618	Metal-binding active site; metal-binding site
393126004619	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393126004620	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393126004621	ATP binding site [chemical binding]; other site
393126004622	Mg++ binding site [ion binding]; other site
393126004623	motif III; other site
393126004624	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126004625	nucleotide binding region [chemical binding]; other site
393126004626	ATP-binding site [chemical binding]; other site
393126004627	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
393126004628	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
393126004629	Uncharacterized conserved protein [Function unknown]; Region: COG0327
393126004630	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
393126004631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
393126004632	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
393126004633	Uncharacterized conserved protein [Function unknown]; Region: COG0327
393126004634	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
393126004635	Family of unknown function (DUF633); Region: DUF633; pfam04816
393126004636	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
393126004637	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
393126004638	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
393126004639	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393126004640	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
393126004641	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393126004642	DNA binding residues [nucleotide binding]
393126004643	DNA primase; Validated; Region: dnaG; PRK05667
393126004644	CHC2 zinc finger; Region: zf-CHC2; pfam01807
393126004645	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
393126004646	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
393126004647	active site
393126004648	metal binding site [ion binding]; metal-binding site
393126004649	interdomain interaction site; other site
393126004650	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
393126004651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
393126004652	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
393126004653	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
393126004654	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
393126004655	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
393126004656	dimer interface [polypeptide binding]; other site
393126004657	motif 1; other site
393126004658	active site
393126004659	motif 2; other site
393126004660	motif 3; other site
393126004661	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
393126004662	Recombination protein O N terminal; Region: RecO_N; pfam11967
393126004663	Recombination protein O C terminal; Region: RecO_C; pfam02565
393126004664	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
393126004665	GTPase Era; Reviewed; Region: era; PRK00089
393126004666	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
393126004667	G1 box; other site
393126004668	GTP/Mg2+ binding site [chemical binding]; other site
393126004669	Switch I region; other site
393126004670	G2 box; other site
393126004671	Switch II region; other site
393126004672	G3 box; other site
393126004673	G4 box; other site
393126004674	G5 box; other site
393126004675	KH domain; Region: KH_2; pfam07650
393126004676	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
393126004677	active site
393126004678	catalytic motif [active]
393126004679	Zn binding site [ion binding]; other site
393126004680	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
393126004681	metal-binding heat shock protein; Provisional; Region: PRK00016
393126004682	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
393126004683	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
393126004684	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126004685	Zn2+ binding site [ion binding]; other site
393126004686	Mg2+ binding site [ion binding]; other site
393126004687	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
393126004688	PhoH-like protein; Region: PhoH; pfam02562
393126004689	Yqey-like protein; Region: YqeY; pfam09424
393126004690	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
393126004691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
393126004692	RNA methyltransferase, RsmE family; Region: TIGR00046
393126004693	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
393126004694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126004695	S-adenosylmethionine binding site [chemical binding]; other site
393126004696	chaperone protein DnaJ; Provisional; Region: PRK14280
393126004697	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
393126004698	HSP70 interaction site [polypeptide binding]; other site
393126004699	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
393126004700	substrate binding site [polypeptide binding]; other site
393126004701	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
393126004702	Zn binding sites [ion binding]; other site
393126004703	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
393126004704	dimer interface [polypeptide binding]; other site
393126004705	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
393126004706	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
393126004707	nucleotide binding site [chemical binding]; other site
393126004708	NEF interaction site [polypeptide binding]; other site
393126004709	SBD interface [polypeptide binding]; other site
393126004710	heat shock protein GrpE; Provisional; Region: PRK14140
393126004711	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
393126004712	dimer interface [polypeptide binding]; other site
393126004713	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
393126004714	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
393126004715	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
393126004716	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
393126004717	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393126004718	FeS/SAM binding site; other site
393126004719	HemN C-terminal domain; Region: HemN_C; pfam06969
393126004720	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
393126004721	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
393126004722	NADP binding site [chemical binding]; other site
393126004723	putative substrate binding site [chemical binding]; other site
393126004724	active site
393126004725	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126004726	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126004727	DNA binding residues [nucleotide binding]
393126004728	putative dimer interface [polypeptide binding]; other site
393126004729	GTP-binding protein LepA; Provisional; Region: PRK05433
393126004730	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
393126004731	G1 box; other site
393126004732	putative GEF interaction site [polypeptide binding]; other site
393126004733	GTP/Mg2+ binding site [chemical binding]; other site
393126004734	Switch I region; other site
393126004735	G2 box; other site
393126004736	G3 box; other site
393126004737	Switch II region; other site
393126004738	G4 box; other site
393126004739	G5 box; other site
393126004740	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
393126004741	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
393126004742	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
393126004743	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
393126004744	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
393126004745	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
393126004746	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
393126004747	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
393126004748	Competence protein; Region: Competence; pfam03772
393126004749	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126004750	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
393126004751	catalytic motif [active]
393126004752	Zn binding site [ion binding]; other site
393126004753	SLBB domain; Region: SLBB; pfam10531
393126004754	comEA protein; Region: comE; TIGR01259
393126004755	Helix-hairpin-helix motif; Region: HHH; pfam00633
393126004756	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393126004757	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126004758	S-adenosylmethionine binding site [chemical binding]; other site
393126004759	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
393126004760	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126004761	Zn2+ binding site [ion binding]; other site
393126004762	Mg2+ binding site [ion binding]; other site
393126004763	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
393126004764	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
393126004765	active site
393126004766	(T/H)XGH motif; other site
393126004767	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
393126004768	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
393126004769	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393126004770	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393126004771	shikimate binding site; other site
393126004772	NAD(P) binding site [chemical binding]; other site
393126004773	GTPase YqeH; Provisional; Region: PRK13796
393126004774	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
393126004775	GTP/Mg2+ binding site [chemical binding]; other site
393126004776	G4 box; other site
393126004777	G5 box; other site
393126004778	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
393126004779	G1 box; other site
393126004780	G1 box; other site
393126004781	GTP/Mg2+ binding site [chemical binding]; other site
393126004782	G2 box; other site
393126004783	Switch I region; other site
393126004784	G2 box; other site
393126004785	Switch I region; other site
393126004786	G3 box; other site
393126004787	G3 box; other site
393126004788	Switch II region; other site
393126004789	Switch II region; other site
393126004790	G4 box; other site
393126004791	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
393126004792	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126004793	motif II; other site
393126004794	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
393126004795	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
393126004796	active site
393126004797	Zn binding site [ion binding]; other site
393126004798	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
393126004799	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
393126004800	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
393126004801	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
393126004802	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
393126004803	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
393126004804	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
393126004805	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
393126004806	Sugar specificity; other site
393126004807	Pyrimidine base specificity; other site
393126004808	ATP-binding site [chemical binding]; other site
393126004809	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
393126004810	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126004811	S-adenosylmethionine binding site [chemical binding]; other site
393126004812	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
393126004813	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
393126004814	dimerization interface [polypeptide binding]; other site
393126004815	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393126004816	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393126004817	hypothetical protein; Provisional; Region: PRK13678
393126004818	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
393126004819	hypothetical protein; Provisional; Region: PRK05473
393126004820	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
393126004821	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
393126004822	motif 1; other site
393126004823	active site
393126004824	motif 2; other site
393126004825	motif 3; other site
393126004826	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
393126004827	DHHA1 domain; Region: DHHA1; pfam02272
393126004828	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126004829	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126004830	Walker A/P-loop; other site
393126004831	ATP binding site [chemical binding]; other site
393126004832	Q-loop/lid; other site
393126004833	ABC transporter signature motif; other site
393126004834	Walker B; other site
393126004835	D-loop; other site
393126004836	H-loop/switch region; other site
393126004837	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126004838	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393126004839	FtsX-like permease family; Region: FtsX; pfam02687
393126004840	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126004841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126004842	active site
393126004843	phosphorylation site [posttranslational modification]
393126004844	intermolecular recognition site; other site
393126004845	dimerization interface [polypeptide binding]; other site
393126004846	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126004847	DNA binding site [nucleotide binding]
393126004848	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
393126004849	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126004850	dimerization interface [polypeptide binding]; other site
393126004851	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126004852	dimer interface [polypeptide binding]; other site
393126004853	phosphorylation site [posttranslational modification]
393126004854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126004855	ATP binding site [chemical binding]; other site
393126004856	Mg2+ binding site [ion binding]; other site
393126004857	G-X-G motif; other site
393126004858	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
393126004859	AAA domain; Region: AAA_30; pfam13604
393126004860	Family description; Region: UvrD_C_2; pfam13538
393126004861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126004862	binding surface
393126004863	TPR motif; other site
393126004864	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
393126004865	TPR repeat; Region: TPR_11; pfam13414
393126004866	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126004867	binding surface
393126004868	TPR motif; other site
393126004869	TPR repeat; Region: TPR_11; pfam13414
393126004870	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
393126004871	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
393126004872	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
393126004873	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393126004874	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393126004875	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126004876	catalytic residue [active]
393126004877	recombination factor protein RarA; Reviewed; Region: PRK13342
393126004878	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126004879	Walker A motif; other site
393126004880	ATP binding site [chemical binding]; other site
393126004881	Walker B motif; other site
393126004882	arginine finger; other site
393126004883	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
393126004884	Predicted transcriptional regulator [Transcription]; Region: COG1959
393126004885	Transcriptional regulator; Region: Rrf2; pfam02082
393126004886	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
393126004887	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
393126004888	Nitrogen regulatory protein P-II; Region: P-II; smart00938
393126004889	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
393126004890	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
393126004891	dimer interface [polypeptide binding]; other site
393126004892	anticodon binding site; other site
393126004893	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
393126004894	homodimer interface [polypeptide binding]; other site
393126004895	motif 1; other site
393126004896	active site
393126004897	motif 2; other site
393126004898	GAD domain; Region: GAD; pfam02938
393126004899	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
393126004900	active site
393126004901	motif 3; other site
393126004902	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
393126004903	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
393126004904	dimer interface [polypeptide binding]; other site
393126004905	motif 1; other site
393126004906	active site
393126004907	motif 2; other site
393126004908	motif 3; other site
393126004909	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
393126004910	anticodon binding site; other site
393126004911	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
393126004912	Bacterial SH3 domain; Region: SH3_3; pfam08239
393126004913	Bacterial SH3 domain; Region: SH3_3; pfam08239
393126004914	Bacterial SH3 domain homologues; Region: SH3b; smart00287
393126004915	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
393126004916	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
393126004917	active site
393126004918	metal binding site [ion binding]; metal-binding site
393126004919	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
393126004920	putative active site [active]
393126004921	dimerization interface [polypeptide binding]; other site
393126004922	putative tRNAtyr binding site [nucleotide binding]; other site
393126004923	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393126004924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126004925	Zn2+ binding site [ion binding]; other site
393126004926	Mg2+ binding site [ion binding]; other site
393126004927	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393126004928	synthetase active site [active]
393126004929	NTP binding site [chemical binding]; other site
393126004930	metal binding site [ion binding]; metal-binding site
393126004931	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
393126004932	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
393126004933	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126004934	active site
393126004935	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
393126004936	DHH family; Region: DHH; pfam01368
393126004937	DHHA1 domain; Region: DHHA1; pfam02272
393126004938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
393126004939	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
393126004940	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
393126004941	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
393126004942	Protein export membrane protein; Region: SecD_SecF; cl14618
393126004943	Protein export membrane protein; Region: SecD_SecF; pfam02355
393126004944	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
393126004945	Preprotein translocase subunit; Region: YajC; pfam02699
393126004946	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
393126004947	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
393126004948	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
393126004949	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
393126004950	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
393126004951	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126004952	Walker A motif; other site
393126004953	ATP binding site [chemical binding]; other site
393126004954	Walker B motif; other site
393126004955	arginine finger; other site
393126004956	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
393126004957	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
393126004958	RuvA N terminal domain; Region: RuvA_N; pfam01330
393126004959	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
393126004960	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393126004961	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126004962	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
393126004963	NAD binding site [chemical binding]; other site
393126004964	dimer interface [polypeptide binding]; other site
393126004965	substrate binding site [chemical binding]; other site
393126004966	hypothetical protein; Validated; Region: PRK00110
393126004967	prephenate dehydratase; Provisional; Region: PRK11898
393126004968	Prephenate dehydratase; Region: PDT; pfam00800
393126004969	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
393126004970	putative L-Phe binding site [chemical binding]; other site
393126004971	GTPase CgtA; Reviewed; Region: obgE; PRK12297
393126004972	GTP1/OBG; Region: GTP1_OBG; pfam01018
393126004973	Obg GTPase; Region: Obg; cd01898
393126004974	G1 box; other site
393126004975	GTP/Mg2+ binding site [chemical binding]; other site
393126004976	Switch I region; other site
393126004977	G2 box; other site
393126004978	G3 box; other site
393126004979	Switch II region; other site
393126004980	G4 box; other site
393126004981	G5 box; other site
393126004982	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
393126004983	glycerol kinase; Provisional; Region: glpK; PRK00047
393126004984	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
393126004985	N- and C-terminal domain interface [polypeptide binding]; other site
393126004986	active site
393126004987	MgATP binding site [chemical binding]; other site
393126004988	catalytic site [active]
393126004989	metal binding site [ion binding]; metal-binding site
393126004990	glycerol binding site [chemical binding]; other site
393126004991	homotetramer interface [polypeptide binding]; other site
393126004992	homodimer interface [polypeptide binding]; other site
393126004993	FBP binding site [chemical binding]; other site
393126004994	protein IIAGlc interface [polypeptide binding]; other site
393126004995	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
393126004996	amphipathic channel; other site
393126004997	Asn-Pro-Ala signature motifs; other site
393126004998	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
393126004999	hypothetical protein; Provisional; Region: PRK14553
393126005000	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
393126005001	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
393126005002	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
393126005003	homodimer interface [polypeptide binding]; other site
393126005004	oligonucleotide binding site [chemical binding]; other site
393126005005	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
393126005006	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
393126005007	Switch I; other site
393126005008	Switch II; other site
393126005009	septum formation inhibitor; Reviewed; Region: minC; PRK00513
393126005010	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
393126005011	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
393126005012	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
393126005013	Protein of unknown function (DUF972); Region: DUF972; pfam06156
393126005014	rod shape-determining protein MreC; Region: MreC; pfam04085
393126005015	rod shape-determining protein MreB; Provisional; Region: PRK13927
393126005016	MreB and similar proteins; Region: MreB_like; cd10225
393126005017	nucleotide binding site [chemical binding]; other site
393126005018	Mg binding site [ion binding]; other site
393126005019	putative protofilament interaction site [polypeptide binding]; other site
393126005020	RodZ interaction site [polypeptide binding]; other site
393126005021	hypothetical protein; Reviewed; Region: PRK00024
393126005022	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
393126005023	MPN+ (JAMM) motif; other site
393126005024	Zinc-binding site [ion binding]; other site
393126005025	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
393126005026	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
393126005027	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
393126005028	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393126005029	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393126005030	AAA domain; Region: AAA_14; pfam13173
393126005031	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
393126005032	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
393126005033	active site
393126005034	HIGH motif; other site
393126005035	nucleotide binding site [chemical binding]; other site
393126005036	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
393126005037	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
393126005038	active site
393126005039	KMSKS motif; other site
393126005040	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
393126005041	tRNA binding surface [nucleotide binding]; other site
393126005042	anticodon binding site; other site
393126005043	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
393126005044	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
393126005045	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393126005046	inhibitor-cofactor binding pocket; inhibition site
393126005047	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005048	catalytic residue [active]
393126005049	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
393126005050	dimer interface [polypeptide binding]; other site
393126005051	active site
393126005052	Schiff base residues; other site
393126005053	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
393126005054	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
393126005055	active site
393126005056	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
393126005057	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
393126005058	domain interfaces; other site
393126005059	active site
393126005060	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
393126005061	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
393126005062	tRNA; other site
393126005063	putative tRNA binding site [nucleotide binding]; other site
393126005064	putative NADP binding site [chemical binding]; other site
393126005065	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
393126005066	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
393126005067	G1 box; other site
393126005068	GTP/Mg2+ binding site [chemical binding]; other site
393126005069	Switch I region; other site
393126005070	G2 box; other site
393126005071	G3 box; other site
393126005072	Switch II region; other site
393126005073	G4 box; other site
393126005074	G5 box; other site
393126005075	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
393126005076	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
393126005077	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
393126005078	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
393126005079	active site
393126005080	dimer interface [polypeptide binding]; other site
393126005081	motif 1; other site
393126005082	motif 2; other site
393126005083	motif 3; other site
393126005084	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
393126005085	anticodon binding site; other site
393126005086	primosomal protein DnaI; Reviewed; Region: PRK08939
393126005087	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
393126005088	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
393126005089	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
393126005090	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
393126005091	ATP cone domain; Region: ATP-cone; pfam03477
393126005092	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
393126005093	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
393126005094	CoA-binding site [chemical binding]; other site
393126005095	ATP-binding [chemical binding]; other site
393126005096	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
393126005097	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
393126005098	DNA binding site [nucleotide binding]
393126005099	catalytic residue [active]
393126005100	H2TH interface [polypeptide binding]; other site
393126005101	putative catalytic residues [active]
393126005102	turnover-facilitating residue; other site
393126005103	intercalation triad [nucleotide binding]; other site
393126005104	8OG recognition residue [nucleotide binding]; other site
393126005105	putative reading head residues; other site
393126005106	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
393126005107	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
393126005108	DNA polymerase I; Provisional; Region: PRK05755
393126005109	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
393126005110	active site
393126005111	metal binding site 1 [ion binding]; metal-binding site
393126005112	putative 5' ssDNA interaction site; other site
393126005113	metal binding site 3; metal-binding site
393126005114	metal binding site 2 [ion binding]; metal-binding site
393126005115	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
393126005116	putative DNA binding site [nucleotide binding]; other site
393126005117	putative metal binding site [ion binding]; other site
393126005118	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
393126005119	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
393126005120	active site
393126005121	DNA binding site [nucleotide binding]
393126005122	catalytic site [active]
393126005123	isocitrate dehydrogenase; Reviewed; Region: PRK07006
393126005124	isocitrate dehydrogenase; Validated; Region: PRK07362
393126005125	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
393126005126	dimer interface [polypeptide binding]; other site
393126005127	Citrate synthase; Region: Citrate_synt; pfam00285
393126005128	active site
393126005129	citrylCoA binding site [chemical binding]; other site
393126005130	oxalacetate/citrate binding site [chemical binding]; other site
393126005131	coenzyme A binding site [chemical binding]; other site
393126005132	catalytic triad [active]
393126005133	Protein of unknown function (DUF441); Region: DUF441; pfam04284
393126005134	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
393126005135	pyruvate kinase; Provisional; Region: PRK06354
393126005136	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
393126005137	domain interfaces; other site
393126005138	active site
393126005139	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
393126005140	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
393126005141	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
393126005142	active site
393126005143	ADP/pyrophosphate binding site [chemical binding]; other site
393126005144	dimerization interface [polypeptide binding]; other site
393126005145	allosteric effector site; other site
393126005146	fructose-1,6-bisphosphate binding site; other site
393126005147	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
393126005148	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
393126005149	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
393126005150	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
393126005151	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
393126005152	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
393126005153	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
393126005154	active site
393126005155	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
393126005156	generic binding surface I; other site
393126005157	generic binding surface II; other site
393126005158	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
393126005159	DHH family; Region: DHH; pfam01368
393126005160	DHHA1 domain; Region: DHHA1; pfam02272
393126005161	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
393126005162	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
393126005163	DNA-binding site [nucleotide binding]; DNA binding site
393126005164	DRTGG domain; Region: DRTGG; pfam07085
393126005165	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
393126005166	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
393126005167	active site 2 [active]
393126005168	active site 1 [active]
393126005169	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
393126005170	metal-dependent hydrolase; Provisional; Region: PRK00685
393126005171	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
393126005172	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
393126005173	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
393126005174	active site
393126005175	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
393126005176	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
393126005177	hexamer interface [polypeptide binding]; other site
393126005178	ligand binding site [chemical binding]; other site
393126005179	putative active site [active]
393126005180	NAD(P) binding site [chemical binding]; other site
393126005181	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393126005182	Ligand Binding Site [chemical binding]; other site
393126005183	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
393126005184	propionate/acetate kinase; Provisional; Region: PRK12379
393126005185	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
393126005186	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005187	S-adenosylmethionine binding site [chemical binding]; other site
393126005188	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
393126005189	dimer interface [polypeptide binding]; other site
393126005190	catalytic triad [active]
393126005191	peroxidatic and resolving cysteines [active]
393126005192	RDD family; Region: RDD; pfam06271
393126005193	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
393126005194	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
393126005195	tandem repeat interface [polypeptide binding]; other site
393126005196	oligomer interface [polypeptide binding]; other site
393126005197	active site residues [active]
393126005198	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
393126005199	ATP-NAD kinase; Region: NAD_kinase; pfam01513
393126005200	ornithine carbamoyltransferase; Provisional; Region: PRK00779
393126005201	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393126005202	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393126005203	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
393126005204	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393126005205	inhibitor-cofactor binding pocket; inhibition site
393126005206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005207	catalytic residue [active]
393126005208	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
393126005209	nucleotide binding site [chemical binding]; other site
393126005210	N-acetyl-L-glutamate binding site [chemical binding]; other site
393126005211	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
393126005212	heterotetramer interface [polypeptide binding]; other site
393126005213	active site pocket [active]
393126005214	cleavage site
393126005215	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
393126005216	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
393126005217	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
393126005218	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
393126005219	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
393126005220	Ligand Binding Site [chemical binding]; other site
393126005221	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393126005222	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393126005223	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126005224	catalytic residue [active]
393126005225	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
393126005226	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
393126005227	GAF domain; Region: GAF_2; pfam13185
393126005228	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
393126005229	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
393126005230	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126005231	RNA binding surface [nucleotide binding]; other site
393126005232	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
393126005233	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
393126005234	active site
393126005235	HIGH motif; other site
393126005236	dimer interface [polypeptide binding]; other site
393126005237	KMSKS motif; other site
393126005238	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126005239	RNA binding surface [nucleotide binding]; other site
393126005240	catabolite control protein A; Region: ccpA; TIGR01481
393126005241	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126005242	DNA binding site [nucleotide binding]
393126005243	domain linker motif; other site
393126005244	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
393126005245	dimerization interface [polypeptide binding]; other site
393126005246	effector binding site; other site
393126005247	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
393126005248	Chorismate mutase type II; Region: CM_2; cl00693
393126005249	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
393126005250	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
393126005251	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
393126005252	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
393126005253	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
393126005254	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
393126005255	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
393126005256	dimer interface [polypeptide binding]; other site
393126005257	decamer (pentamer of dimers) interface [polypeptide binding]; other site
393126005258	catalytic triad [active]
393126005259	peroxidatic and resolving cysteines [active]
393126005260	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
393126005261	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393126005262	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393126005263	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393126005264	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
393126005265	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393126005266	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
393126005267	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
393126005268	putative tRNA-binding site [nucleotide binding]; other site
393126005269	hypothetical protein; Provisional; Region: PRK13668
393126005270	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126005271	catalytic residues [active]
393126005272	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393126005273	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
393126005274	oligomer interface [polypeptide binding]; other site
393126005275	active site
393126005276	metal binding site [ion binding]; metal-binding site
393126005277	Predicted small secreted protein [Function unknown]; Region: COG5584
393126005278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
393126005279	putative homodimer interface [polypeptide binding]; other site
393126005280	putative homotetramer interface [polypeptide binding]; other site
393126005281	putative allosteric switch controlling residues; other site
393126005282	putative metal binding site [ion binding]; other site
393126005283	putative homodimer-homodimer interface [polypeptide binding]; other site
393126005284	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126005285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005286	S-adenosylmethionine binding site [chemical binding]; other site
393126005287	Phosphotransferase enzyme family; Region: APH; pfam01636
393126005288	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
393126005289	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
393126005290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126005291	putative substrate translocation pore; other site
393126005292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126005293	MarR family; Region: MarR; pfam01047
393126005294	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
393126005295	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
393126005296	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
393126005297	homodimer interface [polypeptide binding]; other site
393126005298	substrate-cofactor binding pocket; other site
393126005299	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005300	catalytic residue [active]
393126005301	dipeptidase PepV; Reviewed; Region: PRK07318
393126005302	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
393126005303	active site
393126005304	metal binding site [ion binding]; metal-binding site
393126005305	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
393126005306	nudix motif; other site
393126005307	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
393126005308	putative substrate binding site [chemical binding]; other site
393126005309	putative ATP binding site [chemical binding]; other site
393126005310	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
393126005311	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
393126005312	active site
393126005313	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393126005314	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393126005315	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393126005316	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393126005317	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
393126005318	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
393126005319	substrate binding site [chemical binding]; other site
393126005320	active site
393126005321	catalytic residues [active]
393126005322	heterodimer interface [polypeptide binding]; other site
393126005323	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
393126005324	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
393126005325	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005326	catalytic residue [active]
393126005327	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
393126005328	active site
393126005329	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
393126005330	active site
393126005331	ribulose/triose binding site [chemical binding]; other site
393126005332	phosphate binding site [ion binding]; other site
393126005333	substrate (anthranilate) binding pocket [chemical binding]; other site
393126005334	product (indole) binding pocket [chemical binding]; other site
393126005335	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
393126005336	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
393126005337	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
393126005338	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
393126005339	Glutamine amidotransferase class-I; Region: GATase; pfam00117
393126005340	glutamine binding [chemical binding]; other site
393126005341	catalytic triad [active]
393126005342	anthranilate synthase component I; Provisional; Region: PRK13570
393126005343	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
393126005344	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
393126005345	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
393126005346	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
393126005347	putative catalytic cysteine [active]
393126005348	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
393126005349	putative active site [active]
393126005350	metal binding site [ion binding]; metal-binding site
393126005351	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393126005352	dimer interface [polypeptide binding]; other site
393126005353	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126005354	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126005355	Walker A/P-loop; other site
393126005356	ATP binding site [chemical binding]; other site
393126005357	Q-loop/lid; other site
393126005358	ABC transporter signature motif; other site
393126005359	Walker B; other site
393126005360	D-loop; other site
393126005361	H-loop/switch region; other site
393126005362	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393126005363	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
393126005364	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
393126005365	putative dimer interface [polypeptide binding]; other site
393126005366	catalytic triad [active]
393126005367	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
393126005368	aconitate hydratase; Validated; Region: PRK09277
393126005369	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
393126005370	substrate binding site [chemical binding]; other site
393126005371	ligand binding site [chemical binding]; other site
393126005372	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
393126005373	substrate binding site [chemical binding]; other site
393126005374	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126005375	Heat induced stress protein YflT; Region: YflT; pfam11181
393126005376	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
393126005377	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
393126005378	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126005379	ATP binding site [chemical binding]; other site
393126005380	putative Mg++ binding site [ion binding]; other site
393126005381	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126005382	nucleotide binding region [chemical binding]; other site
393126005383	ATP-binding site [chemical binding]; other site
393126005384	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
393126005385	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
393126005386	Walker A/P-loop; other site
393126005387	ATP binding site [chemical binding]; other site
393126005388	Q-loop/lid; other site
393126005389	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
393126005390	ABC transporter signature motif; other site
393126005391	Walker B; other site
393126005392	D-loop; other site
393126005393	H-loop/switch region; other site
393126005394	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
393126005395	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
393126005396	active site
393126005397	metal binding site [ion binding]; metal-binding site
393126005398	DNA binding site [nucleotide binding]
393126005399	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
393126005400	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
393126005401	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
393126005402	putative acyl-acceptor binding pocket; other site
393126005403	Domain of unknown function (DUF4259); Region: DUF4259; pfam14078
393126005404	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
393126005405	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126005406	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126005407	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
393126005408	Walker A/P-loop; other site
393126005409	ATP binding site [chemical binding]; other site
393126005410	Q-loop/lid; other site
393126005411	ABC transporter signature motif; other site
393126005412	Walker B; other site
393126005413	D-loop; other site
393126005414	H-loop/switch region; other site
393126005415	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126005416	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
393126005417	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126005418	Walker A/P-loop; other site
393126005419	ATP binding site [chemical binding]; other site
393126005420	Q-loop/lid; other site
393126005421	ABC transporter signature motif; other site
393126005422	Walker B; other site
393126005423	D-loop; other site
393126005424	H-loop/switch region; other site
393126005425	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
393126005426	active site
393126005427	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
393126005428	elongation factor Ts; Provisional; Region: tsf; PRK09377
393126005429	UBA/TS-N domain; Region: UBA; pfam00627
393126005430	Elongation factor TS; Region: EF_TS; pfam00889
393126005431	Elongation factor TS; Region: EF_TS; pfam00889
393126005432	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
393126005433	rRNA interaction site [nucleotide binding]; other site
393126005434	S8 interaction site; other site
393126005435	putative laminin-1 binding site; other site
393126005436	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
393126005437	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
393126005438	HIGH motif; other site
393126005439	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
393126005440	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
393126005441	active site
393126005442	KMSKS motif; other site
393126005443	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
393126005444	tRNA binding surface [nucleotide binding]; other site
393126005445	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
393126005446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005447	S-adenosylmethionine binding site [chemical binding]; other site
393126005448	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
393126005449	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
393126005450	active site
393126005451	dimer interface [polypeptide binding]; other site
393126005452	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
393126005453	Ligand Binding Site [chemical binding]; other site
393126005454	Molecular Tunnel; other site
393126005455	S-adenosylmethionine synthetase; Validated; Region: PRK05250
393126005456	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
393126005457	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
393126005458	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
393126005459	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126005460	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393126005461	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393126005462	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126005463	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
393126005464	NAD binding site [chemical binding]; other site
393126005465	dimer interface [polypeptide binding]; other site
393126005466	substrate binding site [chemical binding]; other site
393126005467	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
393126005468	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
393126005469	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
393126005470	nudix motif; other site
393126005471	Uncharacterized conserved protein [Function unknown]; Region: COG0759
393126005472	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393126005473	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
393126005474	metal binding site [ion binding]; metal-binding site
393126005475	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
393126005476	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
393126005477	acyl-activating enzyme (AAE) consensus motif; other site
393126005478	putative AMP binding site [chemical binding]; other site
393126005479	putative active site [active]
393126005480	putative CoA binding site [chemical binding]; other site
393126005481	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
393126005482	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
393126005483	substrate binding site [chemical binding]; other site
393126005484	oxyanion hole (OAH) forming residues; other site
393126005485	trimer interface [polypeptide binding]; other site
393126005486	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
393126005487	Serine hydrolase (FSH1); Region: FSH1; pfam03959
393126005488	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
393126005489	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
393126005490	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
393126005491	dimer interface [polypeptide binding]; other site
393126005492	tetramer interface [polypeptide binding]; other site
393126005493	PYR/PP interface [polypeptide binding]; other site
393126005494	TPP binding site [chemical binding]; other site
393126005495	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
393126005496	TPP-binding site; other site
393126005497	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
393126005498	chorismate binding enzyme; Region: Chorismate_bind; cl10555
393126005499	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
393126005500	UbiA prenyltransferase family; Region: UbiA; pfam01040
393126005501	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
393126005502	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
393126005503	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
393126005504	FAD binding site [chemical binding]; other site
393126005505	cystathionine beta-lyase; Provisional; Region: PRK08064
393126005506	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393126005507	homodimer interface [polypeptide binding]; other site
393126005508	substrate-cofactor binding pocket; other site
393126005509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005510	catalytic residue [active]
393126005511	cystathionine gamma-synthase; Reviewed; Region: PRK08247
393126005512	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393126005513	homodimer interface [polypeptide binding]; other site
393126005514	substrate-cofactor binding pocket; other site
393126005515	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005516	catalytic residue [active]
393126005517	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
393126005518	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
393126005519	THF binding site; other site
393126005520	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
393126005521	substrate binding site [chemical binding]; other site
393126005522	THF binding site; other site
393126005523	zinc-binding site [ion binding]; other site
393126005524	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126005525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126005526	putative substrate translocation pore; other site
393126005527	ferric uptake regulator; Provisional; Region: fur; PRK09462
393126005528	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393126005529	metal binding site 2 [ion binding]; metal-binding site
393126005530	putative DNA binding helix; other site
393126005531	metal binding site 1 [ion binding]; metal-binding site
393126005532	dimer interface [polypeptide binding]; other site
393126005533	structural Zn2+ binding site [ion binding]; other site
393126005534	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
393126005535	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
393126005536	NAD binding site [chemical binding]; other site
393126005537	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
393126005538	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393126005539	inhibitor-cofactor binding pocket; inhibition site
393126005540	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126005541	catalytic residue [active]
393126005542	Predicted membrane protein [Function unknown]; Region: COG4129
393126005543	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
393126005544	hypothetical protein; Provisional; Region: PRK13662
393126005545	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
393126005546	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
393126005547	putative NAD(P) binding site [chemical binding]; other site
393126005548	active site
393126005549	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
393126005550	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393126005551	minor groove reading motif; other site
393126005552	helix-hairpin-helix signature motif; other site
393126005553	substrate binding pocket [chemical binding]; other site
393126005554	active site
393126005555	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
393126005556	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
393126005557	DNA binding and oxoG recognition site [nucleotide binding]
393126005558	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
393126005559	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
393126005560	trimer interface [polypeptide binding]; other site
393126005561	active site
393126005562	WVELL protein; Region: WVELL; pfam14043
393126005563	recombination regulator RecX; Provisional; Region: recX; PRK14135
393126005564	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393126005565	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
393126005566	NAD(P) binding site [chemical binding]; other site
393126005567	active site
393126005568	Predicted integral membrane protein [Function unknown]; Region: COG0392
393126005569	Uncharacterized conserved protein [Function unknown]; Region: COG2898
393126005570	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
393126005571	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
393126005572	Cation efflux family; Region: Cation_efflux; pfam01545
393126005573	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393126005574	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393126005575	PAS fold; Region: PAS_4; pfam08448
393126005576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393126005577	putative active site [active]
393126005578	heme pocket [chemical binding]; other site
393126005579	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
393126005580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
393126005581	dimer interface [polypeptide binding]; other site
393126005582	putative CheW interface [polypeptide binding]; other site
393126005583	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
393126005584	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
393126005585	dimer interface [polypeptide binding]; other site
393126005586	active site
393126005587	Mn binding site [ion binding]; other site
393126005588	TRAM domain; Region: TRAM; cl01282
393126005589	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
393126005590	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005591	S-adenosylmethionine binding site [chemical binding]; other site
393126005592	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
393126005593	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
393126005594	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
393126005595	Substrate-binding site [chemical binding]; other site
393126005596	Substrate specificity [chemical binding]; other site
393126005597	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
393126005598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
393126005599	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
393126005600	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
393126005601	active site
393126005602	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
393126005603	flavodoxin, short chain; Region: flav_short; TIGR01753
393126005604	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
393126005605	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
393126005606	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126005607	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126005608	putative substrate translocation pore; other site
393126005609	rod-share determining protein MreBH; Provisional; Region: PRK13929
393126005610	MreB and similar proteins; Region: MreB_like; cd10225
393126005611	nucleotide binding site [chemical binding]; other site
393126005612	Mg binding site [ion binding]; other site
393126005613	putative protofilament interaction site [polypeptide binding]; other site
393126005614	RodZ interaction site [polypeptide binding]; other site
393126005615	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393126005616	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005617	S-adenosylmethionine binding site [chemical binding]; other site
393126005618	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126005619	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126005620	Uncharacterized conserved protein [Function unknown]; Region: COG4748
393126005621	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
393126005622	Uncharacterized conserved protein [Function unknown]; Region: COG3589
393126005623	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
393126005624	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126005625	methionine cluster; other site
393126005626	active site
393126005627	phosphorylation site [posttranslational modification]
393126005628	metal binding site [ion binding]; metal-binding site
393126005629	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126005630	active site
393126005631	P-loop; other site
393126005632	phosphorylation site [posttranslational modification]
393126005633	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
393126005634	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
393126005635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126005636	Walker A motif; other site
393126005637	ATP binding site [chemical binding]; other site
393126005638	Walker B motif; other site
393126005639	arginine finger; other site
393126005640	Transcriptional antiterminator [Transcription]; Region: COG3933
393126005641	PRD domain; Region: PRD; pfam00874
393126005642	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126005643	active pocket/dimerization site; other site
393126005644	active site
393126005645	phosphorylation site [posttranslational modification]
393126005646	PRD domain; Region: PRD; pfam00874
393126005647	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
393126005648	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393126005649	ATP binding site [chemical binding]; other site
393126005650	putative Mg++ binding site [ion binding]; other site
393126005651	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126005652	nucleotide binding region [chemical binding]; other site
393126005653	ATP-binding site [chemical binding]; other site
393126005654	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393126005655	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126005656	Walker A/P-loop; other site
393126005657	ATP binding site [chemical binding]; other site
393126005658	Q-loop/lid; other site
393126005659	ABC transporter signature motif; other site
393126005660	Walker B; other site
393126005661	D-loop; other site
393126005662	H-loop/switch region; other site
393126005663	Predicted transcriptional regulators [Transcription]; Region: COG1725
393126005664	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126005665	DNA-binding site [nucleotide binding]; DNA binding site
393126005666	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126005667	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126005668	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126005669	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126005670	DNA binding site [nucleotide binding]
393126005671	domain linker motif; other site
393126005672	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126005673	dimerization interface [polypeptide binding]; other site
393126005674	ligand binding site [chemical binding]; other site
393126005675	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
393126005676	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
393126005677	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
393126005678	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
393126005679	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393126005680	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126005681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126005682	dimer interface [polypeptide binding]; other site
393126005683	conserved gate region; other site
393126005684	putative PBP binding loops; other site
393126005685	ABC-ATPase subunit interface; other site
393126005686	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126005687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126005688	dimer interface [polypeptide binding]; other site
393126005689	conserved gate region; other site
393126005690	putative PBP binding loops; other site
393126005691	ABC-ATPase subunit interface; other site
393126005692	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
393126005693	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393126005694	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
393126005695	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
393126005696	active site
393126005697	dimer interface [polypeptide binding]; other site
393126005698	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
393126005699	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
393126005700	active site
393126005701	FMN binding site [chemical binding]; other site
393126005702	substrate binding site [chemical binding]; other site
393126005703	3Fe-4S cluster binding site [ion binding]; other site
393126005704	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
393126005705	domain interface; other site
393126005706	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126005707	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126005708	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393126005709	putative dimerization interface [polypeptide binding]; other site
393126005710	Predicted acetyltransferase [General function prediction only]; Region: COG3153
393126005711	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
393126005712	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
393126005713	putative active site [active]
393126005714	metal binding site [ion binding]; metal-binding site
393126005715	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393126005716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393126005717	substrate binding pocket [chemical binding]; other site
393126005718	membrane-bound complex binding site; other site
393126005719	hinge residues; other site
393126005720	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126005721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126005722	Walker A/P-loop; other site
393126005723	ATP binding site [chemical binding]; other site
393126005724	Q-loop/lid; other site
393126005725	ABC transporter signature motif; other site
393126005726	Walker B; other site
393126005727	D-loop; other site
393126005728	H-loop/switch region; other site
393126005729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126005730	dimer interface [polypeptide binding]; other site
393126005731	conserved gate region; other site
393126005732	putative PBP binding loops; other site
393126005733	ABC-ATPase subunit interface; other site
393126005734	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393126005735	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
393126005736	dimer interface [polypeptide binding]; other site
393126005737	phosphorylation site [posttranslational modification]
393126005738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126005739	ATP binding site [chemical binding]; other site
393126005740	Mg2+ binding site [ion binding]; other site
393126005741	G-X-G motif; other site
393126005742	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
393126005743	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393126005744	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
393126005745	active site
393126005746	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
393126005747	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
393126005748	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
393126005749	putative NAD(P) binding site [chemical binding]; other site
393126005750	active site
393126005751	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126005752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126005753	active site
393126005754	phosphorylation site [posttranslational modification]
393126005755	intermolecular recognition site; other site
393126005756	dimerization interface [polypeptide binding]; other site
393126005757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126005758	DNA binding site [nucleotide binding]
393126005759	FtsX-like permease family; Region: FtsX; pfam02687
393126005760	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393126005761	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126005762	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126005763	Walker A/P-loop; other site
393126005764	ATP binding site [chemical binding]; other site
393126005765	Q-loop/lid; other site
393126005766	ABC transporter signature motif; other site
393126005767	Walker B; other site
393126005768	D-loop; other site
393126005769	H-loop/switch region; other site
393126005770	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
393126005771	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
393126005772	ADP binding site [chemical binding]; other site
393126005773	magnesium binding site [ion binding]; other site
393126005774	putative shikimate binding site; other site
393126005775	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
393126005776	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
393126005777	TRAM domain; Region: TRAM; pfam01938
393126005778	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126005779	S-adenosylmethionine binding site [chemical binding]; other site
393126005780	putative lipid kinase; Reviewed; Region: PRK13337
393126005781	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393126005782	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
393126005783	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
393126005784	GatB domain; Region: GatB_Yqey; pfam02637
393126005785	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
393126005786	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
393126005787	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
393126005788	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
393126005789	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
393126005790	putative dimer interface [polypeptide binding]; other site
393126005791	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
393126005792	putative dimer interface [polypeptide binding]; other site
393126005793	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
393126005794	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
393126005795	nucleotide binding pocket [chemical binding]; other site
393126005796	K-X-D-G motif; other site
393126005797	catalytic site [active]
393126005798	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
393126005799	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
393126005800	Dimer interface [polypeptide binding]; other site
393126005801	BRCT sequence motif; other site
393126005802	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
393126005803	Part of AAA domain; Region: AAA_19; pfam13245
393126005804	Family description; Region: UvrD_C_2; pfam13538
393126005805	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
393126005806	PcrB family; Region: PcrB; pfam01884
393126005807	substrate binding site [chemical binding]; other site
393126005808	putative active site [active]
393126005809	dimer interface [polypeptide binding]; other site
393126005810	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
393126005811	Na2 binding site [ion binding]; other site
393126005812	putative substrate binding site 1 [chemical binding]; other site
393126005813	Na binding site 1 [ion binding]; other site
393126005814	putative substrate binding site 2 [chemical binding]; other site
393126005815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
393126005816	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
393126005817	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
393126005818	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
393126005819	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
393126005820	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
393126005821	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
393126005822	purine monophosphate binding site [chemical binding]; other site
393126005823	dimer interface [polypeptide binding]; other site
393126005824	putative catalytic residues [active]
393126005825	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
393126005826	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
393126005827	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
393126005828	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
393126005829	active site
393126005830	substrate binding site [chemical binding]; other site
393126005831	cosubstrate binding site; other site
393126005832	catalytic site [active]
393126005833	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
393126005834	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
393126005835	dimerization interface [polypeptide binding]; other site
393126005836	putative ATP binding site [chemical binding]; other site
393126005837	amidophosphoribosyltransferase; Provisional; Region: PRK06781
393126005838	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
393126005839	active site
393126005840	tetramer interface [polypeptide binding]; other site
393126005841	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126005842	active site
393126005843	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
393126005844	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
393126005845	dimerization interface [polypeptide binding]; other site
393126005846	ATP binding site [chemical binding]; other site
393126005847	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
393126005848	dimerization interface [polypeptide binding]; other site
393126005849	ATP binding site [chemical binding]; other site
393126005850	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
393126005851	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
393126005852	putative active site [active]
393126005853	catalytic triad [active]
393126005854	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
393126005855	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
393126005856	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
393126005857	ATP binding site [chemical binding]; other site
393126005858	active site
393126005859	substrate binding site [chemical binding]; other site
393126005860	adenylosuccinate lyase; Provisional; Region: PRK07492
393126005861	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
393126005862	tetramer interface [polypeptide binding]; other site
393126005863	active site
393126005864	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
393126005865	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
393126005866	NAD binding site [chemical binding]; other site
393126005867	ATP-grasp domain; Region: ATP-grasp; pfam02222
393126005868	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
393126005869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
393126005870	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126005871	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
393126005872	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126005873	Zn2+ binding site [ion binding]; other site
393126005874	Mg2+ binding site [ion binding]; other site
393126005875	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393126005876	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393126005877	Walker A/P-loop; other site
393126005878	ATP binding site [chemical binding]; other site
393126005879	Q-loop/lid; other site
393126005880	ABC transporter signature motif; other site
393126005881	Walker B; other site
393126005882	D-loop; other site
393126005883	H-loop/switch region; other site
393126005884	peptidase T; Region: peptidase-T; TIGR01882
393126005885	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
393126005886	metal binding site [ion binding]; metal-binding site
393126005887	dimer interface [polypeptide binding]; other site
393126005888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
393126005889	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
393126005890	active site
393126005891	putative catalytic site [active]
393126005892	DNA binding site [nucleotide binding]
393126005893	putative phosphate binding site [ion binding]; other site
393126005894	metal binding site A [ion binding]; metal-binding site
393126005895	AP binding site [nucleotide binding]; other site
393126005896	metal binding site B [ion binding]; metal-binding site
393126005897	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
393126005898	23S rRNA binding site [nucleotide binding]; other site
393126005899	L21 binding site [polypeptide binding]; other site
393126005900	L13 binding site [polypeptide binding]; other site
393126005901	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
393126005902	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
393126005903	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
393126005904	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
393126005905	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126005906	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126005907	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126005908	Substrate binding site [chemical binding]; other site
393126005909	Leucine rich repeat; Region: LRR_8; pfam13855
393126005910	LRR adjacent; Region: LRR_adjacent; pfam08191
393126005911	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
393126005912	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
393126005913	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393126005914	DNA binding residues [nucleotide binding]
393126005915	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393126005916	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393126005917	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126005918	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
393126005919	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
393126005920	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
393126005921	RimM N-terminal domain; Region: RimM; pfam01782
393126005922	PRC-barrel domain; Region: PRC; pfam05239
393126005923	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
393126005924	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
393126005925	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
393126005926	catalytic triad [active]
393126005927	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
393126005928	KH domain; Region: KH_4; pfam13083
393126005929	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
393126005930	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
393126005931	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
393126005932	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
393126005933	signal recognition particle protein; Provisional; Region: PRK10867
393126005934	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
393126005935	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
393126005936	P loop; other site
393126005937	GTP binding site [chemical binding]; other site
393126005938	Signal peptide binding domain; Region: SRP_SPB; pfam02978
393126005939	putative DNA-binding protein; Validated; Region: PRK00118
393126005940	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
393126005941	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
393126005942	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
393126005943	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
393126005944	P loop; other site
393126005945	GTP binding site [chemical binding]; other site
393126005946	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
393126005947	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
393126005948	Walker A/P-loop; other site
393126005949	ATP binding site [chemical binding]; other site
393126005950	Q-loop/lid; other site
393126005951	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
393126005952	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
393126005953	ABC transporter signature motif; other site
393126005954	Walker B; other site
393126005955	D-loop; other site
393126005956	H-loop/switch region; other site
393126005957	ribonuclease III; Reviewed; Region: rnc; PRK00102
393126005958	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
393126005959	dimerization interface [polypeptide binding]; other site
393126005960	active site
393126005961	metal binding site [ion binding]; metal-binding site
393126005962	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
393126005963	dsRNA binding site [nucleotide binding]; other site
393126005964	acyl carrier protein; Provisional; Region: acpP; PRK00982
393126005965	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
393126005966	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
393126005967	NAD(P) binding site [chemical binding]; other site
393126005968	homotetramer interface [polypeptide binding]; other site
393126005969	homodimer interface [polypeptide binding]; other site
393126005970	active site
393126005971	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
393126005972	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
393126005973	putative phosphate acyltransferase; Provisional; Region: PRK05331
393126005974	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
393126005975	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
393126005976	active site 2 [active]
393126005977	active site 1 [active]
393126005978	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
393126005979	Y-family of DNA polymerases; Region: PolY; cl12025
393126005980	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
393126005981	generic binding surface II; other site
393126005982	ssDNA binding site; other site
393126005983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126005984	ATP binding site [chemical binding]; other site
393126005985	putative Mg++ binding site [ion binding]; other site
393126005986	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126005987	nucleotide binding region [chemical binding]; other site
393126005988	ATP-binding site [chemical binding]; other site
393126005989	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
393126005990	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
393126005991	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
393126005992	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
393126005993	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
393126005994	putative L-serine binding site [chemical binding]; other site
393126005995	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
393126005996	DAK2 domain; Region: Dak2; pfam02734
393126005997	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
393126005998	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
393126005999	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
393126006000	Thiamine pyrophosphokinase; Region: TPK; cd07995
393126006001	active site
393126006002	dimerization interface [polypeptide binding]; other site
393126006003	thiamine binding site [chemical binding]; other site
393126006004	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126006005	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126006006	substrate binding site [chemical binding]; other site
393126006007	hexamer interface [polypeptide binding]; other site
393126006008	metal binding site [ion binding]; metal-binding site
393126006009	GTPase RsgA; Reviewed; Region: PRK00098
393126006010	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
393126006011	RNA binding site [nucleotide binding]; other site
393126006012	homodimer interface [polypeptide binding]; other site
393126006013	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
393126006014	GTPase/Zn-binding domain interface [polypeptide binding]; other site
393126006015	GTP/Mg2+ binding site [chemical binding]; other site
393126006016	G4 box; other site
393126006017	G1 box; other site
393126006018	Switch I region; other site
393126006019	G2 box; other site
393126006020	G3 box; other site
393126006021	Switch II region; other site
393126006022	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
393126006023	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
393126006024	active site
393126006025	ATP binding site [chemical binding]; other site
393126006026	substrate binding site [chemical binding]; other site
393126006027	activation loop (A-loop); other site
393126006028	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
393126006029	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393126006030	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393126006031	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393126006032	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
393126006033	Protein phosphatase 2C; Region: PP2C; pfam00481
393126006034	active site
393126006035	16S rRNA methyltransferase B; Provisional; Region: PRK14902
393126006036	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
393126006037	putative RNA binding site [nucleotide binding]; other site
393126006038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126006039	S-adenosylmethionine binding site [chemical binding]; other site
393126006040	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
393126006041	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
393126006042	putative active site [active]
393126006043	substrate binding site [chemical binding]; other site
393126006044	putative cosubstrate binding site; other site
393126006045	catalytic site [active]
393126006046	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
393126006047	substrate binding site [chemical binding]; other site
393126006048	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
393126006049	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126006050	ATP binding site [chemical binding]; other site
393126006051	putative Mg++ binding site [ion binding]; other site
393126006052	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126006053	ATP-binding site [chemical binding]; other site
393126006054	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
393126006055	Flavoprotein; Region: Flavoprotein; pfam02441
393126006056	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
393126006057	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
393126006058	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
393126006059	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
393126006060	catalytic site [active]
393126006061	G-X2-G-X-G-K; other site
393126006062	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
393126006063	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
393126006064	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
393126006065	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
393126006066	Domain of unknown function (DUF814); Region: DUF814; pfam05670
393126006067	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
393126006068	putative NAD(P) binding site [chemical binding]; other site
393126006069	homodimer interface [polypeptide binding]; other site
393126006070	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126006071	active site
393126006072	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
393126006073	active site
393126006074	dimer interface [polypeptide binding]; other site
393126006075	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
393126006076	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
393126006077	heterodimer interface [polypeptide binding]; other site
393126006078	active site
393126006079	FMN binding site [chemical binding]; other site
393126006080	homodimer interface [polypeptide binding]; other site
393126006081	substrate binding site [chemical binding]; other site
393126006082	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
393126006083	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
393126006084	FAD binding pocket [chemical binding]; other site
393126006085	FAD binding motif [chemical binding]; other site
393126006086	phosphate binding motif [ion binding]; other site
393126006087	beta-alpha-beta structure motif; other site
393126006088	NAD binding pocket [chemical binding]; other site
393126006089	Iron coordination center [ion binding]; other site
393126006090	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
393126006091	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393126006092	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
393126006093	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
393126006094	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393126006095	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393126006096	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
393126006097	IMP binding site; other site
393126006098	dimer interface [polypeptide binding]; other site
393126006099	interdomain contacts; other site
393126006100	partial ornithine binding site; other site
393126006101	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
393126006102	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
393126006103	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
393126006104	catalytic site [active]
393126006105	subunit interface [polypeptide binding]; other site
393126006106	dihydroorotase; Validated; Region: pyrC; PRK09357
393126006107	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393126006108	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
393126006109	active site
393126006110	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
393126006111	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393126006112	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393126006113	uracil transporter; Provisional; Region: PRK10720
393126006114	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
393126006115	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126006116	active site
393126006117	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393126006118	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393126006119	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126006120	RNA binding surface [nucleotide binding]; other site
393126006121	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393126006122	active site
393126006123	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
393126006124	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393126006125	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393126006126	multidrug efflux protein; Reviewed; Region: PRK01766
393126006127	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
393126006128	cation binding site [ion binding]; other site
393126006129	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393126006130	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
393126006131	metal binding site [ion binding]; metal-binding site
393126006132	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393126006133	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126006134	ABC-ATPase subunit  interface; other site
393126006135	dimer interface [polypeptide binding]; other site
393126006136	putative PBP binding regions; other site
393126006137	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
393126006138	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393126006139	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126006140	MarR family; Region: MarR; pfam01047
393126006141	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
393126006142	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
393126006143	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
393126006144	protein binding site [polypeptide binding]; other site
393126006145	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
393126006146	Catalytic dyad [active]
393126006147	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
393126006148	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
393126006149	metal-binding site [ion binding]
393126006150	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
393126006151	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
393126006152	metal-binding site [ion binding]
393126006153	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126006154	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126006155	motif II; other site
393126006156	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
393126006157	putative homodimer interface [polypeptide binding]; other site
393126006158	putative homotetramer interface [polypeptide binding]; other site
393126006159	putative allosteric switch controlling residues; other site
393126006160	putative metal binding site [ion binding]; other site
393126006161	putative homodimer-homodimer interface [polypeptide binding]; other site
393126006162	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
393126006163	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
393126006164	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
393126006165	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
393126006166	hypothetical protein; Provisional; Region: PRK13672
393126006167	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126006168	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126006169	methionine sulfoxide reductase B; Provisional; Region: PRK00222
393126006170	SelR domain; Region: SelR; pfam01641
393126006171	methionine sulfoxide reductase A; Provisional; Region: PRK14054
393126006172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
393126006173	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
393126006174	active site
393126006175	catalytic triad [active]
393126006176	oxyanion hole [active]
393126006177	EDD domain protein, DegV family; Region: DegV; TIGR00762
393126006178	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393126006179	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
393126006180	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
393126006181	HTH domain; Region: HTH_11; pfam08279
393126006182	FOG: CBS domain [General function prediction only]; Region: COG0517
393126006183	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
393126006184	PEP synthetase regulatory protein; Provisional; Region: PRK05339
393126006185	pyruvate phosphate dikinase; Provisional; Region: PRK09279
393126006186	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
393126006187	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393126006188	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
393126006189	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126006190	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
393126006191	Predicted membrane protein [Function unknown]; Region: COG4129
393126006192	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
393126006193	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
393126006194	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393126006195	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393126006196	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
393126006197	active site
393126006198	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
393126006199	substrate binding site [chemical binding]; other site
393126006200	metal binding site [ion binding]; metal-binding site
393126006201	Methyltransferase domain; Region: Methyltransf_23; pfam13489
393126006202	Methyltransferase domain; Region: Methyltransf_18; pfam12847
393126006203	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
393126006204	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
393126006205	folate binding site [chemical binding]; other site
393126006206	NADP+ binding site [chemical binding]; other site
393126006207	thymidylate synthase; Region: thym_sym; TIGR03284
393126006208	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
393126006209	dimerization interface [polypeptide binding]; other site
393126006210	active site
393126006211	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393126006212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126006213	Walker A/P-loop; other site
393126006214	ATP binding site [chemical binding]; other site
393126006215	Q-loop/lid; other site
393126006216	ABC transporter signature motif; other site
393126006217	Walker B; other site
393126006218	D-loop; other site
393126006219	H-loop/switch region; other site
393126006220	ABC transporter; Region: ABC_tran_2; pfam12848
393126006221	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126006222	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
393126006223	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
393126006224	Potassium binding sites [ion binding]; other site
393126006225	Cesium cation binding sites [ion binding]; other site
393126006226	manganese transport transcriptional regulator; Provisional; Region: PRK03902
393126006227	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
393126006228	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
393126006229	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393126006230	DNA-binding site [nucleotide binding]; DNA binding site
393126006231	RNA-binding motif; other site
393126006232	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
393126006233	RNA/DNA hybrid binding site [nucleotide binding]; other site
393126006234	active site
393126006235	5'-3' exonuclease; Region: 53EXOc; smart00475
393126006236	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
393126006237	active site
393126006238	metal binding site 1 [ion binding]; metal-binding site
393126006239	putative 5' ssDNA interaction site; other site
393126006240	metal binding site 3; metal-binding site
393126006241	metal binding site 2 [ion binding]; metal-binding site
393126006242	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
393126006243	putative DNA binding site [nucleotide binding]; other site
393126006244	putative metal binding site [ion binding]; other site
393126006245	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
393126006246	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
393126006247	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
393126006248	putative active site [active]
393126006249	xanthine permease; Region: pbuX; TIGR03173
393126006250	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126006251	active site
393126006252	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
393126006253	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
393126006254	active site
393126006255	Zn binding site [ion binding]; other site
393126006256	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
393126006257	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
393126006258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393126006259	cell division protein GpsB; Provisional; Region: PRK14127
393126006260	DivIVA domain; Region: DivI1A_domain; TIGR03544
393126006261	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
393126006262	hypothetical protein; Provisional; Region: PRK13660
393126006263	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
393126006264	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
393126006265	Transglycosylase; Region: Transgly; pfam00912
393126006266	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
393126006267	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393126006268	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
393126006269	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393126006270	minor groove reading motif; other site
393126006271	helix-hairpin-helix signature motif; other site
393126006272	substrate binding pocket [chemical binding]; other site
393126006273	active site
393126006274	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
393126006275	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
393126006276	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
393126006277	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
393126006278	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
393126006279	putative dimer interface [polypeptide binding]; other site
393126006280	putative anticodon binding site; other site
393126006281	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
393126006282	homodimer interface [polypeptide binding]; other site
393126006283	motif 1; other site
393126006284	motif 2; other site
393126006285	active site
393126006286	motif 3; other site
393126006287	aspartate aminotransferase; Provisional; Region: PRK05764
393126006288	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126006289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126006290	homodimer interface [polypeptide binding]; other site
393126006291	catalytic residue [active]
393126006292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
393126006293	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393126006294	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
393126006295	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
393126006296	active site
393126006297	catalytic site [active]
393126006298	substrate binding site [chemical binding]; other site
393126006299	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
393126006300	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393126006301	putative Mg++ binding site [ion binding]; other site
393126006302	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
393126006303	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
393126006304	tetramerization interface [polypeptide binding]; other site
393126006305	active site
393126006306	pantoate--beta-alanine ligase; Region: panC; TIGR00018
393126006307	Pantoate-beta-alanine ligase; Region: PanC; cd00560
393126006308	active site
393126006309	ATP-binding site [chemical binding]; other site
393126006310	pantoate-binding site; other site
393126006311	HXXH motif; other site
393126006312	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
393126006313	active site
393126006314	oligomerization interface [polypeptide binding]; other site
393126006315	metal binding site [ion binding]; metal-binding site
393126006316	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126006317	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393126006318	catalytic residues [active]
393126006319	Biotin operon repressor [Transcription]; Region: BirA; COG1654
393126006320	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
393126006321	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
393126006322	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
393126006323	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
393126006324	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
393126006325	active site
393126006326	NTP binding site [chemical binding]; other site
393126006327	metal binding triad [ion binding]; metal-binding site
393126006328	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
393126006329	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
393126006330	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
393126006331	active site
393126006332	dimer interfaces [polypeptide binding]; other site
393126006333	catalytic residues [active]
393126006334	dihydrodipicolinate reductase; Provisional; Region: PRK00048
393126006335	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
393126006336	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
393126006337	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
393126006338	homodimer interface [polypeptide binding]; other site
393126006339	metal binding site [ion binding]; metal-binding site
393126006340	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393126006341	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126006342	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126006343	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126006344	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
393126006345	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393126006346	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393126006347	metal binding site [ion binding]; metal-binding site
393126006348	active site
393126006349	I-site; other site
393126006350	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
393126006351	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393126006352	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393126006353	metal binding site [ion binding]; metal-binding site
393126006354	active site
393126006355	I-site; other site
393126006356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393126006357	malate dehydrogenase; Provisional; Region: PRK13529
393126006358	Malic enzyme, N-terminal domain; Region: malic; pfam00390
393126006359	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
393126006360	NAD(P) binding pocket [chemical binding]; other site
393126006361	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
393126006362	Beta-lactamase; Region: Beta-lactamase; pfam00144
393126006363	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
393126006364	Pyruvate formate lyase 1; Region: PFL1; cd01678
393126006365	coenzyme A binding site [chemical binding]; other site
393126006366	active site
393126006367	catalytic residues [active]
393126006368	glycine loop; other site
393126006369	HI0933-like protein; Region: HI0933_like; pfam03486
393126006370	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126006371	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
393126006372	Predicted membrane protein [Function unknown]; Region: COG4347
393126006373	hypothetical protein; Provisional; Region: PRK03636
393126006374	UPF0302 domain; Region: UPF0302; pfam08864
393126006375	IDEAL domain; Region: IDEAL; pfam08858
393126006376	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
393126006377	binding surface
393126006378	TPR motif; other site
393126006379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126006380	binding surface
393126006381	Tetratricopeptide repeat; Region: TPR_16; pfam13432
393126006382	TPR motif; other site
393126006383	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
393126006384	binding surface
393126006385	TPR motif; other site
393126006386	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
393126006387	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
393126006388	hinge; other site
393126006389	active site
393126006390	prephenate dehydrogenase; Validated; Region: PRK06545
393126006391	prephenate dehydrogenase; Validated; Region: PRK08507
393126006392	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
393126006393	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
393126006394	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126006395	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126006396	homodimer interface [polypeptide binding]; other site
393126006397	catalytic residue [active]
393126006398	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
393126006399	homotrimer interaction site [polypeptide binding]; other site
393126006400	active site
393126006401	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
393126006402	active site
393126006403	dimer interface [polypeptide binding]; other site
393126006404	metal binding site [ion binding]; metal-binding site
393126006405	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
393126006406	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
393126006407	Tetramer interface [polypeptide binding]; other site
393126006408	active site
393126006409	FMN-binding site [chemical binding]; other site
393126006410	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
393126006411	active site
393126006412	multimer interface [polypeptide binding]; other site
393126006413	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393126006414	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393126006415	substrate binding pocket [chemical binding]; other site
393126006416	chain length determination region; other site
393126006417	substrate-Mg2+ binding site; other site
393126006418	catalytic residues [active]
393126006419	aspartate-rich region 1; other site
393126006420	active site lid residues [active]
393126006421	aspartate-rich region 2; other site
393126006422	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
393126006423	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126006424	S-adenosylmethionine binding site [chemical binding]; other site
393126006425	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
393126006426	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
393126006427	homodecamer interface [polypeptide binding]; other site
393126006428	GTP cyclohydrolase I; Provisional; Region: PLN03044
393126006429	active site
393126006430	putative catalytic site residues [active]
393126006431	zinc binding site [ion binding]; other site
393126006432	GTP-CH-I/GFRP interaction surface; other site
393126006433	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
393126006434	IHF dimer interface [polypeptide binding]; other site
393126006435	IHF - DNA interface [nucleotide binding]; other site
393126006436	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
393126006437	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
393126006438	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
393126006439	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
393126006440	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
393126006441	GTP-binding protein Der; Reviewed; Region: PRK00093
393126006442	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
393126006443	G1 box; other site
393126006444	GTP/Mg2+ binding site [chemical binding]; other site
393126006445	Switch I region; other site
393126006446	G2 box; other site
393126006447	Switch II region; other site
393126006448	G3 box; other site
393126006449	G4 box; other site
393126006450	G5 box; other site
393126006451	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
393126006452	G1 box; other site
393126006453	GTP/Mg2+ binding site [chemical binding]; other site
393126006454	Switch I region; other site
393126006455	G2 box; other site
393126006456	G3 box; other site
393126006457	Switch II region; other site
393126006458	G4 box; other site
393126006459	G5 box; other site
393126006460	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
393126006461	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
393126006462	RNA binding site [nucleotide binding]; other site
393126006463	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
393126006464	RNA binding site [nucleotide binding]; other site
393126006465	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
393126006466	RNA binding site [nucleotide binding]; other site
393126006467	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393126006468	RNA binding site [nucleotide binding]; other site
393126006469	cytidylate kinase; Provisional; Region: cmk; PRK00023
393126006470	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
393126006471	CMP-binding site; other site
393126006472	The sites determining sugar specificity; other site
393126006473	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
393126006474	active site
393126006475	homotetramer interface [polypeptide binding]; other site
393126006476	homodimer interface [polypeptide binding]; other site
393126006477	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126006478	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
393126006479	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
393126006480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126006481	ATP binding site [chemical binding]; other site
393126006482	putative Mg++ binding site [ion binding]; other site
393126006483	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126006484	nucleotide binding region [chemical binding]; other site
393126006485	ATP-binding site [chemical binding]; other site
393126006486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
393126006487	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
393126006488	Predicted membrane protein [Function unknown]; Region: COG3601
393126006489	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
393126006490	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
393126006491	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126006492	dimerization interface [polypeptide binding]; other site
393126006493	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
393126006494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126006495	dimer interface [polypeptide binding]; other site
393126006496	phosphorylation site [posttranslational modification]
393126006497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126006498	ATP binding site [chemical binding]; other site
393126006499	Mg2+ binding site [ion binding]; other site
393126006500	G-X-G motif; other site
393126006501	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126006502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126006503	active site
393126006504	phosphorylation site [posttranslational modification]
393126006505	intermolecular recognition site; other site
393126006506	dimerization interface [polypeptide binding]; other site
393126006507	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126006508	DNA binding site [nucleotide binding]
393126006509	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
393126006510	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126006511	RNA binding surface [nucleotide binding]; other site
393126006512	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
393126006513	active site
393126006514	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
393126006515	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
393126006516	diaminopimelate decarboxylase; Region: lysA; TIGR01048
393126006517	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
393126006518	active site
393126006519	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393126006520	substrate binding site [chemical binding]; other site
393126006521	catalytic residues [active]
393126006522	dimer interface [polypeptide binding]; other site
393126006523	purine nucleoside phosphorylase; Provisional; Region: PRK08202
393126006524	phosphopentomutase; Provisional; Region: PRK05362
393126006525	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
393126006526	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
393126006527	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
393126006528	active site
393126006529	Int/Topo IB signature motif; other site
393126006530	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393126006531	metal binding site 2 [ion binding]; metal-binding site
393126006532	putative DNA binding helix; other site
393126006533	metal binding site 1 [ion binding]; metal-binding site
393126006534	dimer interface [polypeptide binding]; other site
393126006535	structural Zn2+ binding site [ion binding]; other site
393126006536	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393126006537	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126006538	ABC-ATPase subunit  interface; other site
393126006539	dimer interface [polypeptide binding]; other site
393126006540	putative PBP binding regions; other site
393126006541	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393126006542	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126006543	ABC-ATPase subunit  interface; other site
393126006544	dimer interface [polypeptide binding]; other site
393126006545	putative PBP binding regions; other site
393126006546	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
393126006547	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
393126006548	putative ligand binding residues [chemical binding]; other site
393126006549	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393126006550	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393126006551	Walker A/P-loop; other site
393126006552	ATP binding site [chemical binding]; other site
393126006553	Q-loop/lid; other site
393126006554	ABC transporter signature motif; other site
393126006555	Walker B; other site
393126006556	D-loop; other site
393126006557	H-loop/switch region; other site
393126006558	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
393126006559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126006560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126006561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126006562	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
393126006563	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393126006564	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126006565	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126006566	Walker A/P-loop; other site
393126006567	ATP binding site [chemical binding]; other site
393126006568	Q-loop/lid; other site
393126006569	ABC transporter signature motif; other site
393126006570	Walker B; other site
393126006571	D-loop; other site
393126006572	H-loop/switch region; other site
393126006573	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
393126006574	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
393126006575	dimer interface [polypeptide binding]; other site
393126006576	ADP-ribose binding site [chemical binding]; other site
393126006577	active site
393126006578	nudix motif; other site
393126006579	metal binding site [ion binding]; metal-binding site
393126006580	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
393126006581	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
393126006582	Creatinine amidohydrolase; Region: Creatininase; pfam02633
393126006583	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
393126006584	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
393126006585	active site
393126006586	intersubunit interface [polypeptide binding]; other site
393126006587	catalytic residue [active]
393126006588	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
393126006589	active site
393126006590	substrate binding pocket [chemical binding]; other site
393126006591	homodimer interaction site [polypeptide binding]; other site
393126006592	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
393126006593	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
393126006594	active site
393126006595	P-loop; other site
393126006596	phosphorylation site [posttranslational modification]
393126006597	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126006598	active site
393126006599	phosphorylation site [posttranslational modification]
393126006600	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126006601	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126006602	DNA-binding site [nucleotide binding]; DNA binding site
393126006603	UTRA domain; Region: UTRA; pfam07702
393126006604	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
393126006605	active site
393126006606	DNA polymerase IV; Validated; Region: PRK02406
393126006607	DNA binding site [nucleotide binding]
393126006608	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
393126006609	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393126006610	NAD(P) binding site [chemical binding]; other site
393126006611	active site
393126006612	ribonuclease Z; Region: RNase_Z; TIGR02651
393126006613	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
393126006614	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
393126006615	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
393126006616	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
393126006617	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
393126006618	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393126006619	Coenzyme A binding pocket [chemical binding]; other site
393126006620	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
393126006621	6-phosphogluconate dehydratase; Region: edd; TIGR01196
393126006622	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
393126006623	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393126006624	PYR/PP interface [polypeptide binding]; other site
393126006625	dimer interface [polypeptide binding]; other site
393126006626	TPP binding site [chemical binding]; other site
393126006627	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393126006628	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
393126006629	TPP-binding site [chemical binding]; other site
393126006630	dimer interface [polypeptide binding]; other site
393126006631	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
393126006632	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
393126006633	putative valine binding site [chemical binding]; other site
393126006634	dimer interface [polypeptide binding]; other site
393126006635	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
393126006636	ketol-acid reductoisomerase; Provisional; Region: PRK05479
393126006637	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
393126006638	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
393126006639	2-isopropylmalate synthase; Validated; Region: PRK00915
393126006640	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
393126006641	active site
393126006642	catalytic residues [active]
393126006643	metal binding site [ion binding]; metal-binding site
393126006644	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
393126006645	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
393126006646	tartrate dehydrogenase; Region: TTC; TIGR02089
393126006647	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
393126006648	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
393126006649	substrate binding site [chemical binding]; other site
393126006650	ligand binding site [chemical binding]; other site
393126006651	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
393126006652	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
393126006653	substrate binding site [chemical binding]; other site
393126006654	threonine dehydratase; Validated; Region: PRK08639
393126006655	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
393126006656	tetramer interface [polypeptide binding]; other site
393126006657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126006658	catalytic residue [active]
393126006659	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
393126006660	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
393126006661	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
393126006662	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
393126006663	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
393126006664	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
393126006665	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126006666	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126006667	DNA binding site [nucleotide binding]
393126006668	domain linker motif; other site
393126006669	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126006670	dimerization interface [polypeptide binding]; other site
393126006671	ligand binding site [chemical binding]; other site
393126006672	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
393126006673	intersubunit interface [polypeptide binding]; other site
393126006674	active site
393126006675	catalytic residue [active]
393126006676	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393126006677	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
393126006678	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393126006679	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393126006680	active pocket/dimerization site; other site
393126006681	active site
393126006682	phosphorylation site [posttranslational modification]
393126006683	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393126006684	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
393126006685	putative active site [active]
393126006686	SIS domain; Region: SIS; pfam01380
393126006687	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393126006688	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393126006689	dimer interface [polypeptide binding]; other site
393126006690	active site
393126006691	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393126006692	dimer interface [polypeptide binding]; other site
393126006693	active site
393126006694	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
393126006695	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
393126006696	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393126006697	active site
393126006698	phosphorylation site [posttranslational modification]
393126006699	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126006700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126006701	DNA-binding site [nucleotide binding]; DNA binding site
393126006702	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393126006703	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126006704	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126006705	DNA-binding site [nucleotide binding]; DNA binding site
393126006706	UTRA domain; Region: UTRA; pfam07702
393126006707	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126006708	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126006709	active site
393126006710	catalytic tetrad [active]
393126006711	acetolactate synthase; Reviewed; Region: PRK08617
393126006712	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393126006713	PYR/PP interface [polypeptide binding]; other site
393126006714	dimer interface [polypeptide binding]; other site
393126006715	TPP binding site [chemical binding]; other site
393126006716	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393126006717	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
393126006718	TPP-binding site [chemical binding]; other site
393126006719	dimer interface [polypeptide binding]; other site
393126006720	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126006721	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
393126006722	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
393126006723	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126006724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126006725	dimer interface [polypeptide binding]; other site
393126006726	conserved gate region; other site
393126006727	ABC-ATPase subunit interface; other site
393126006728	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393126006729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126006730	dimer interface [polypeptide binding]; other site
393126006731	conserved gate region; other site
393126006732	ABC-ATPase subunit interface; other site
393126006733	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
393126006734	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126006735	active site
393126006736	phosphorylation site [posttranslational modification]
393126006737	intermolecular recognition site; other site
393126006738	dimerization interface [polypeptide binding]; other site
393126006739	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126006740	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
393126006741	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126006742	dimerization interface [polypeptide binding]; other site
393126006743	Histidine kinase; Region: His_kinase; pfam06580
393126006744	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126006745	ATP binding site [chemical binding]; other site
393126006746	Mg2+ binding site [ion binding]; other site
393126006747	G-X-G motif; other site
393126006748	Predicted integral membrane protein [Function unknown]; Region: COG5578
393126006749	Uncharacterized conserved protein [Function unknown]; Region: COG3538
393126006750	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
393126006751	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393126006752	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
393126006753	active site
393126006754	metal binding site [ion binding]; metal-binding site
393126006755	homodimer interface [polypeptide binding]; other site
393126006756	catalytic site [active]
393126006757	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393126006758	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393126006759	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
393126006760	active site
393126006761	catalytic site [active]
393126006762	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393126006763	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393126006764	DNA-binding site [nucleotide binding]; DNA binding site
393126006765	RNA-binding motif; other site
393126006766	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
393126006767	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
393126006768	active site
393126006769	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
393126006770	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393126006771	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393126006772	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
393126006773	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
393126006774	HIGH motif; other site
393126006775	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
393126006776	active site
393126006777	KMSKS motif; other site
393126006778	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
393126006779	tRNA binding surface [nucleotide binding]; other site
393126006780	anticodon binding site; other site
393126006781	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
393126006782	DivIVA protein; Region: DivIVA; pfam05103
393126006783	DivIVA domain; Region: DivI1A_domain; TIGR03544
393126006784	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
393126006785	HTH domain; Region: HTH_11; pfam08279
393126006786	3H domain; Region: 3H; pfam02829
393126006787	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393126006788	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393126006789	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126006790	catalytic residue [active]
393126006791	L-aspartate oxidase; Provisional; Region: PRK08071
393126006792	L-aspartate oxidase; Provisional; Region: PRK06175
393126006793	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
393126006794	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
393126006795	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
393126006796	dimerization interface [polypeptide binding]; other site
393126006797	active site
393126006798	quinolinate synthetase; Provisional; Region: PRK09375
393126006799	Leucine rich repeat; Region: LRR_8; pfam13855
393126006800	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126006801	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126006802	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393126006803	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126006804	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126006805	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
393126006806	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126006807	RNA binding surface [nucleotide binding]; other site
393126006808	YGGT family; Region: YGGT; pfam02325
393126006809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
393126006810	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
393126006811	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393126006812	catalytic residue [active]
393126006813	cell division protein FtsZ; Validated; Region: PRK09330
393126006814	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
393126006815	nucleotide binding site [chemical binding]; other site
393126006816	SulA interaction site; other site
393126006817	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
393126006818	Cell division protein FtsA; Region: FtsA; smart00842
393126006819	Cell division protein FtsA; Region: FtsA; pfam14450
393126006820	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
393126006821	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
393126006822	Cell division protein FtsQ; Region: FtsQ; pfam03799
393126006823	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
393126006824	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
393126006825	active site
393126006826	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
393126006827	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393126006828	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393126006829	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
393126006830	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
393126006831	Mg++ binding site [ion binding]; other site
393126006832	putative catalytic motif [active]
393126006833	putative substrate binding site [chemical binding]; other site
393126006834	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
393126006835	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393126006836	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393126006837	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393126006838	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
393126006839	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393126006840	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393126006841	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
393126006842	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
393126006843	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
393126006844	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
393126006845	MraW methylase family; Region: Methyltransf_5; pfam01795
393126006846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
393126006847	MraZ protein; Region: MraZ; pfam02381
393126006848	MraZ protein; Region: MraZ; pfam02381
393126006849	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126006850	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126006851	putative substrate translocation pore; other site
393126006852	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
393126006853	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
393126006854	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
393126006855	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
393126006856	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
393126006857	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
393126006858	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
393126006859	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
393126006860	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
393126006861	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
393126006862	hypothetical protein; Provisional; Region: PRK13670
393126006863	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393126006864	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393126006865	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
393126006866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126006867	Walker A/P-loop; other site
393126006868	ATP binding site [chemical binding]; other site
393126006869	Q-loop/lid; other site
393126006870	ABC transporter signature motif; other site
393126006871	Walker B; other site
393126006872	D-loop; other site
393126006873	H-loop/switch region; other site
393126006874	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
393126006875	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
393126006876	protein binding site [polypeptide binding]; other site
393126006877	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
393126006878	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
393126006879	active site
393126006880	(T/H)XGH motif; other site
393126006881	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
393126006882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126006883	S-adenosylmethionine binding site [chemical binding]; other site
393126006884	hypothetical protein; Provisional; Region: PRK02886
393126006885	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
393126006886	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
393126006887	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
393126006888	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
393126006889	UbiA prenyltransferase family; Region: UbiA; pfam01040
393126006890	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
393126006891	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
393126006892	Ion transport protein; Region: Ion_trans; pfam00520
393126006893	Ion channel; Region: Ion_trans_2; pfam07885
393126006894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
393126006895	MOSC domain; Region: MOSC; pfam03473
393126006896	3-alpha domain; Region: 3-alpha; pfam03475
393126006897	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
393126006898	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
393126006899	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
393126006900	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
393126006901	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
393126006902	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
393126006903	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
393126006904	active site
393126006905	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
393126006906	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
393126006907	ring oligomerisation interface [polypeptide binding]; other site
393126006908	ATP/Mg binding site [chemical binding]; other site
393126006909	stacking interactions; other site
393126006910	hinge regions; other site
393126006911	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
393126006912	oligomerisation interface [polypeptide binding]; other site
393126006913	mobile loop; other site
393126006914	roof hairpin; other site
393126006915	CAAX protease self-immunity; Region: Abi; pfam02517
393126006916	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
393126006917	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
393126006918	CoA binding domain; Region: CoA_binding; pfam02629
393126006919	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393126006920	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126006921	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126006922	ABC transporter; Region: ABC_tran_2; pfam12848
393126006923	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126006924	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393126006925	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
393126006926	UGMP family protein; Validated; Region: PRK09604
393126006927	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
393126006928	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
393126006929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126006930	Coenzyme A binding pocket [chemical binding]; other site
393126006931	Glycoprotease family; Region: Peptidase_M22; pfam00814
393126006932	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
393126006933	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
393126006934	camphor resistance protein CrcB; Provisional; Region: PRK14214
393126006935	camphor resistance protein CrcB; Provisional; Region: PRK14231
393126006936	Uncharacterized conserved protein [Function unknown]; Region: COG4832
393126006937	Phosphotransferase enzyme family; Region: APH; pfam01636
393126006938	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
393126006939	active site
393126006940	substrate binding site [chemical binding]; other site
393126006941	ATP binding site [chemical binding]; other site
393126006942	Cna protein B-type domain; Region: Cna_B; pfam05738
393126006943	Cna protein B-type domain; Region: Cna_B; pfam05738
393126006944	Cna protein B-type domain; Region: Cna_B; pfam05738
393126006945	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126006946	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126006947	non-specific DNA binding site [nucleotide binding]; other site
393126006948	salt bridge; other site
393126006949	sequence-specific DNA binding site [nucleotide binding]; other site
393126006950	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393126006951	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393126006952	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126006953	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126006954	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
393126006955	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
393126006956	substrate binding pocket [chemical binding]; other site
393126006957	argininosuccinate synthase; Provisional; Region: PRK13820
393126006958	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
393126006959	ANP binding site [chemical binding]; other site
393126006960	Substrate Binding Site II [chemical binding]; other site
393126006961	Substrate Binding Site I [chemical binding]; other site
393126006962	argininosuccinate lyase; Provisional; Region: PRK00855
393126006963	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
393126006964	active sites [active]
393126006965	tetramer interface [polypeptide binding]; other site
393126006966	BCCT family transporter; Region: BCCT; pfam02028
393126006967	hypothetical protein; Provisional; Region: PRK06357
393126006968	active site
393126006969	intersubunit interface [polypeptide binding]; other site
393126006970	Zn2+ binding site [ion binding]; other site
393126006971	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
393126006972	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
393126006973	putative substrate binding site [chemical binding]; other site
393126006974	putative ATP binding site [chemical binding]; other site
393126006975	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393126006976	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393126006977	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393126006978	active site
393126006979	P-loop; other site
393126006980	phosphorylation site [posttranslational modification]
393126006981	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126006982	active site
393126006983	phosphorylation site [posttranslational modification]
393126006984	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126006985	PRD domain; Region: PRD; pfam00874
393126006986	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126006987	active site
393126006988	P-loop; other site
393126006989	phosphorylation site [posttranslational modification]
393126006990	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
393126006991	active site
393126006992	phosphorylation site [posttranslational modification]
393126006993	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
393126006994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126006995	DNA-binding site [nucleotide binding]; DNA binding site
393126006996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126006997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126006998	homodimer interface [polypeptide binding]; other site
393126006999	catalytic residue [active]
393126007000	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
393126007001	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
393126007002	active site
393126007003	multimer interface [polypeptide binding]; other site
393126007004	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
393126007005	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
393126007006	predicted active site [active]
393126007007	catalytic triad [active]
393126007008	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
393126007009	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
393126007010	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
393126007011	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
393126007012	G1 box; other site
393126007013	GTP/Mg2+ binding site [chemical binding]; other site
393126007014	Switch I region; other site
393126007015	G2 box; other site
393126007016	G3 box; other site
393126007017	Switch II region; other site
393126007018	G4 box; other site
393126007019	G5 box; other site
393126007020	Nucleoside recognition; Region: Gate; pfam07670
393126007021	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
393126007022	Nucleoside recognition; Region: Gate; pfam07670
393126007023	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
393126007024	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393126007025	putative active site [active]
393126007026	putative metal binding site [ion binding]; other site
393126007027	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126007028	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
393126007029	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126007030	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
393126007031	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
393126007032	active site
393126007033	dimer interface [polypeptide binding]; other site
393126007034	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393126007035	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
393126007036	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
393126007037	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393126007038	dimer interface [polypeptide binding]; other site
393126007039	FMN binding site [chemical binding]; other site
393126007040	NADPH bind site [chemical binding]; other site
393126007041	Helix-turn-helix domain; Region: HTH_17; pfam12728
393126007042	putative heme peroxidase; Provisional; Region: PRK12276
393126007043	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126007044	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126007045	Walker A/P-loop; other site
393126007046	ATP binding site [chemical binding]; other site
393126007047	Q-loop/lid; other site
393126007048	ABC transporter signature motif; other site
393126007049	Walker B; other site
393126007050	D-loop; other site
393126007051	H-loop/switch region; other site
393126007052	FtsX-like permease family; Region: FtsX; pfam02687
393126007053	FtsX-like permease family; Region: FtsX; pfam02687
393126007054	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126007055	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126007056	Coenzyme A binding pocket [chemical binding]; other site
393126007057	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
393126007058	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
393126007059	active site
393126007060	substrate binding site [chemical binding]; other site
393126007061	metal binding site [ion binding]; metal-binding site
393126007062	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
393126007063	YbbR-like protein; Region: YbbR; pfam07949
393126007064	YbbR-like protein; Region: YbbR; pfam07949
393126007065	YbbR-like protein; Region: YbbR; pfam07949
393126007066	Uncharacterized conserved protein [Function unknown]; Region: COG1624
393126007067	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
393126007068	maltose phosphorylase; Provisional; Region: PRK13807
393126007069	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
393126007070	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
393126007071	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
393126007072	Predicted integral membrane protein [Function unknown]; Region: COG5521
393126007073	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126007074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007075	dimer interface [polypeptide binding]; other site
393126007076	conserved gate region; other site
393126007077	putative PBP binding loops; other site
393126007078	ABC-ATPase subunit interface; other site
393126007079	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007080	dimer interface [polypeptide binding]; other site
393126007081	conserved gate region; other site
393126007082	putative PBP binding loops; other site
393126007083	ABC-ATPase subunit interface; other site
393126007084	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
393126007085	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126007086	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
393126007087	homodimer interface [polypeptide binding]; other site
393126007088	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
393126007089	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
393126007090	active site
393126007091	homodimer interface [polypeptide binding]; other site
393126007092	catalytic site [active]
393126007093	CAAX protease self-immunity; Region: Abi; cl00558
393126007094	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126007095	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126007096	DNA binding site [nucleotide binding]
393126007097	domain linker motif; other site
393126007098	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393126007099	ligand binding site [chemical binding]; other site
393126007100	dimerization interface [polypeptide binding]; other site
393126007101	Amino acid permease; Region: AA_permease_2; pfam13520
393126007102	K+ potassium transporter; Region: K_trans; cl15781
393126007103	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126007104	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126007105	ligand binding site [chemical binding]; other site
393126007106	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126007107	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393126007108	ligand binding site [chemical binding]; other site
393126007109	flexible hinge region; other site
393126007110	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126007111	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393126007112	intersubunit interface [polypeptide binding]; other site
393126007113	active site
393126007114	zinc binding site [ion binding]; other site
393126007115	Na+ binding site [ion binding]; other site
393126007116	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393126007117	intersubunit interface [polypeptide binding]; other site
393126007118	active site
393126007119	zinc binding site [ion binding]; other site
393126007120	Na+ binding site [ion binding]; other site
393126007121	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126007122	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126007123	active site
393126007124	P-loop; other site
393126007125	phosphorylation site [posttranslational modification]
393126007126	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126007127	active site
393126007128	phosphorylation site [posttranslational modification]
393126007129	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126007130	HTH domain; Region: HTH_11; pfam08279
393126007131	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126007132	PRD domain; Region: PRD; pfam00874
393126007133	PRD domain; Region: PRD; pfam00874
393126007134	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126007135	active site
393126007136	P-loop; other site
393126007137	phosphorylation site [posttranslational modification]
393126007138	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
393126007139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126007140	Walker A/P-loop; other site
393126007141	ATP binding site [chemical binding]; other site
393126007142	Q-loop/lid; other site
393126007143	ABC transporter signature motif; other site
393126007144	Walker B; other site
393126007145	D-loop; other site
393126007146	H-loop/switch region; other site
393126007147	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
393126007148	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
393126007149	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
393126007150	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126007151	Coenzyme A binding pocket [chemical binding]; other site
393126007152	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393126007153	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
393126007154	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
393126007155	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393126007156	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126007157	DNA-binding site [nucleotide binding]; DNA binding site
393126007158	UTRA domain; Region: UTRA; pfam07702
393126007159	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
393126007160	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
393126007161	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126007162	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126007163	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
393126007164	putative dimerization interface [polypeptide binding]; other site
393126007165	Predicted membrane protein [Function unknown]; Region: COG2855
393126007166	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
393126007167	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
393126007168	putative metal binding site [ion binding]; other site
393126007169	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
393126007170	homodimer interface [polypeptide binding]; other site
393126007171	chemical substrate binding site [chemical binding]; other site
393126007172	oligomer interface [polypeptide binding]; other site
393126007173	metal binding site [ion binding]; metal-binding site
393126007174	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126007175	catalytic residues [active]
393126007176	flavodoxin; Provisional; Region: PRK09271
393126007177	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
393126007178	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
393126007179	dimer interface [polypeptide binding]; other site
393126007180	putative radical transfer pathway; other site
393126007181	diiron center [ion binding]; other site
393126007182	tyrosyl radical; other site
393126007183	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
393126007184	Class I ribonucleotide reductase; Region: RNR_I; cd01679
393126007185	active site
393126007186	dimer interface [polypeptide binding]; other site
393126007187	catalytic residues [active]
393126007188	effector binding site; other site
393126007189	R2 peptide binding site; other site
393126007190	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
393126007191	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
393126007192	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393126007193	CsbD-like; Region: CsbD; cl17424
393126007194	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126007195	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126007196	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393126007197	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393126007198	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
393126007199	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
393126007200	conserved cys residue [active]
393126007201	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393126007202	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126007203	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126007204	Cupin domain; Region: Cupin_2; cl17218
393126007205	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126007206	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126007207	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126007208	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
393126007209	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126007210	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126007211	ligand binding site [chemical binding]; other site
393126007212	flexible hinge region; other site
393126007213	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
393126007214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393126007215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126007216	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
393126007217	dimer interface [polypeptide binding]; other site
393126007218	active site
393126007219	metal binding site [ion binding]; metal-binding site
393126007220	glutathione binding site [chemical binding]; other site
393126007221	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
393126007222	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
393126007223	FMN binding site [chemical binding]; other site
393126007224	substrate binding site [chemical binding]; other site
393126007225	putative catalytic residue [active]
393126007226	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
393126007227	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
393126007228	Coenzyme A transferase; Region: CoA_trans; smart00882
393126007229	Coenzyme A transferase; Region: CoA_trans; cl17247
393126007230	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126007231	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
393126007232	Walker A motif; other site
393126007233	ATP binding site [chemical binding]; other site
393126007234	Walker B motif; other site
393126007235	arginine finger; other site
393126007236	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
393126007237	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
393126007238	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393126007239	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393126007240	metal binding site [ion binding]; metal-binding site
393126007241	active site
393126007242	I-site; other site
393126007243	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
393126007244	classical (c) SDRs; Region: SDR_c; cd05233
393126007245	NAD(P) binding site [chemical binding]; other site
393126007246	active site
393126007247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126007248	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126007249	Tic20-like protein; Region: Tic20; pfam09685
393126007250	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393126007251	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007252	Collagen binding domain; Region: Collagen_bind; pfam05737
393126007253	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007254	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007255	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007256	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007257	Cna protein B-type domain; Region: Cna_B; pfam05738
393126007258	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007259	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007260	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007261	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
393126007262	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
393126007263	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
393126007264	active site
393126007265	catalytic site [active]
393126007266	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393126007267	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393126007268	Walker A/P-loop; other site
393126007269	ATP binding site [chemical binding]; other site
393126007270	Q-loop/lid; other site
393126007271	ABC transporter signature motif; other site
393126007272	Walker B; other site
393126007273	D-loop; other site
393126007274	H-loop/switch region; other site
393126007275	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393126007276	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126007277	ABC-ATPase subunit  interface; other site
393126007278	dimer interface [polypeptide binding]; other site
393126007279	putative PBP binding regions; other site
393126007280	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
393126007281	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
393126007282	putative ligand binding residues [chemical binding]; other site
393126007283	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393126007284	heme-binding site [chemical binding]; other site
393126007285	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
393126007286	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393126007287	heme-binding site [chemical binding]; other site
393126007288	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393126007289	heme-binding site [chemical binding]; other site
393126007290	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
393126007291	heme uptake protein IsdC; Region: IsdC; TIGR03656
393126007292	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393126007293	heme-binding site [chemical binding]; other site
393126007294	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
393126007295	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393126007296	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
393126007297	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
393126007298	active site
393126007299	Zn binding site [ion binding]; other site
393126007300	Competence protein CoiA-like family; Region: CoiA; cl11541
393126007301	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
393126007302	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
393126007303	ArsC family; Region: ArsC; pfam03960
393126007304	putative catalytic residues [active]
393126007305	thiol/disulfide switch; other site
393126007306	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
393126007307	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
393126007308	Walker A/P-loop; other site
393126007309	ATP binding site [chemical binding]; other site
393126007310	Q-loop/lid; other site
393126007311	ABC transporter signature motif; other site
393126007312	Walker B; other site
393126007313	D-loop; other site
393126007314	H-loop/switch region; other site
393126007315	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
393126007316	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
393126007317	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
393126007318	Walker A/P-loop; other site
393126007319	ATP binding site [chemical binding]; other site
393126007320	Q-loop/lid; other site
393126007321	ABC transporter signature motif; other site
393126007322	Walker B; other site
393126007323	D-loop; other site
393126007324	H-loop/switch region; other site
393126007325	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
393126007326	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393126007327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007328	dimer interface [polypeptide binding]; other site
393126007329	conserved gate region; other site
393126007330	putative PBP binding loops; other site
393126007331	ABC-ATPase subunit interface; other site
393126007332	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393126007333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007334	dimer interface [polypeptide binding]; other site
393126007335	conserved gate region; other site
393126007336	putative PBP binding loops; other site
393126007337	ABC-ATPase subunit interface; other site
393126007338	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393126007339	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393126007340	peptide binding site [polypeptide binding]; other site
393126007341	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
393126007342	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
393126007343	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
393126007344	active site
393126007345	HIGH motif; other site
393126007346	dimer interface [polypeptide binding]; other site
393126007347	KMSKS motif; other site
393126007348	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
393126007349	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126007350	MarR family; Region: MarR; pfam01047
393126007351	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
393126007352	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
393126007353	dimer interface [polypeptide binding]; other site
393126007354	active site
393126007355	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
393126007356	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
393126007357	dimer interface [polypeptide binding]; other site
393126007358	active site
393126007359	CoA binding pocket [chemical binding]; other site
393126007360	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126007361	SH3-like domain; Region: SH3_8; pfam13457
393126007362	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
393126007363	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126007364	catalytic core [active]
393126007365	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393126007366	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
393126007367	Clp amino terminal domain; Region: Clp_N; pfam02861
393126007368	Clp amino terminal domain; Region: Clp_N; pfam02861
393126007369	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126007370	Walker A motif; other site
393126007371	ATP binding site [chemical binding]; other site
393126007372	Walker B motif; other site
393126007373	arginine finger; other site
393126007374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126007375	Walker A motif; other site
393126007376	ATP binding site [chemical binding]; other site
393126007377	Walker B motif; other site
393126007378	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
393126007379	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
393126007380	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
393126007381	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126007382	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007383	active site
393126007384	motif I; other site
393126007385	motif II; other site
393126007386	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393126007387	Predicted acetyltransferase [General function prediction only]; Region: COG3393
393126007388	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
393126007389	ferrochelatase; Provisional; Region: PRK12435
393126007390	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
393126007391	C-terminal domain interface [polypeptide binding]; other site
393126007392	active site
393126007393	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
393126007394	active site
393126007395	N-terminal domain interface [polypeptide binding]; other site
393126007396	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
393126007397	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
393126007398	substrate binding site [chemical binding]; other site
393126007399	active site
393126007400	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
393126007401	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
393126007402	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393126007403	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126007404	Walker A/P-loop; other site
393126007405	ATP binding site [chemical binding]; other site
393126007406	Q-loop/lid; other site
393126007407	ABC transporter signature motif; other site
393126007408	Walker B; other site
393126007409	D-loop; other site
393126007410	H-loop/switch region; other site
393126007411	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
393126007412	HIT family signature motif; other site
393126007413	catalytic residue [active]
393126007414	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
393126007415	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
393126007416	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
393126007417	SurA N-terminal domain; Region: SurA_N_3; cl07813
393126007418	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
393126007419	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
393126007420	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
393126007421	generic binding surface II; other site
393126007422	generic binding surface I; other site
393126007423	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126007424	Zn2+ binding site [ion binding]; other site
393126007425	Mg2+ binding site [ion binding]; other site
393126007426	Uncharacterized conserved protein [Function unknown]; Region: COG4717
393126007427	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
393126007428	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
393126007429	active site
393126007430	metal binding site [ion binding]; metal-binding site
393126007431	DNA binding site [nucleotide binding]
393126007432	hypothetical protein; Provisional; Region: PRK13676
393126007433	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
393126007434	fumarate hydratase; Reviewed; Region: fumC; PRK00485
393126007435	Class II fumarases; Region: Fumarase_classII; cd01362
393126007436	active site
393126007437	tetramer interface [polypeptide binding]; other site
393126007438	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
393126007439	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126007440	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126007441	Walker A/P-loop; other site
393126007442	ATP binding site [chemical binding]; other site
393126007443	Q-loop/lid; other site
393126007444	ABC transporter signature motif; other site
393126007445	Walker B; other site
393126007446	D-loop; other site
393126007447	H-loop/switch region; other site
393126007448	Transglycosylase; Region: Transgly; pfam00912
393126007449	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
393126007450	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393126007451	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393126007452	Low molecular weight phosphatase family; Region: LMWPc; cl00105
393126007453	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393126007454	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
393126007455	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393126007456	Domain of unknown function DUF21; Region: DUF21; pfam01595
393126007457	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393126007458	Transporter associated domain; Region: CorC_HlyC; smart01091
393126007459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126007460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126007461	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393126007462	putative dimerization interface [polypeptide binding]; other site
393126007463	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
393126007464	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
393126007465	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
393126007466	active site
393126007467	FMN binding site [chemical binding]; other site
393126007468	substrate binding site [chemical binding]; other site
393126007469	putative catalytic residue [active]
393126007470	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126007471	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126007472	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
393126007473	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393126007474	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393126007475	shikimate binding site; other site
393126007476	NAD(P) binding site [chemical binding]; other site
393126007477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126007478	putative substrate translocation pore; other site
393126007479	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126007480	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126007481	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126007482	putative substrate translocation pore; other site
393126007483	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393126007484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126007485	Walker A/P-loop; other site
393126007486	ATP binding site [chemical binding]; other site
393126007487	Q-loop/lid; other site
393126007488	ABC transporter signature motif; other site
393126007489	Walker B; other site
393126007490	D-loop; other site
393126007491	H-loop/switch region; other site
393126007492	Predicted transcriptional regulators [Transcription]; Region: COG1725
393126007493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393126007494	DNA-binding site [nucleotide binding]; DNA binding site
393126007495	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393126007496	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393126007497	DNA binding site [nucleotide binding]
393126007498	active site
393126007499	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
393126007500	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
393126007501	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126007502	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126007503	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393126007504	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393126007505	active site
393126007506	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
393126007507	putative dimer interface [polypeptide binding]; other site
393126007508	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126007509	ligand binding site [chemical binding]; other site
393126007510	Zn binding site [ion binding]; other site
393126007511	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
393126007512	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
393126007513	active site
393126007514	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126007515	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126007516	active site
393126007517	catalytic tetrad [active]
393126007518	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
393126007519	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
393126007520	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393126007521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393126007522	substrate binding pocket [chemical binding]; other site
393126007523	membrane-bound complex binding site; other site
393126007524	hinge residues; other site
393126007525	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393126007526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007527	dimer interface [polypeptide binding]; other site
393126007528	conserved gate region; other site
393126007529	putative PBP binding loops; other site
393126007530	ABC-ATPase subunit interface; other site
393126007531	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393126007532	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393126007533	Walker A/P-loop; other site
393126007534	ATP binding site [chemical binding]; other site
393126007535	Q-loop/lid; other site
393126007536	ABC transporter signature motif; other site
393126007537	Walker B; other site
393126007538	D-loop; other site
393126007539	H-loop/switch region; other site
393126007540	aspartate aminotransferase; Provisional; Region: PRK06348
393126007541	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126007542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126007543	homodimer interface [polypeptide binding]; other site
393126007544	catalytic residue [active]
393126007545	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
393126007546	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393126007547	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007548	motif II; other site
393126007549	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393126007550	intracellular protease, PfpI family; Region: PfpI; TIGR01382
393126007551	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
393126007552	proposed catalytic triad [active]
393126007553	conserved cys residue [active]
393126007554	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
393126007555	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126007556	methionine cluster; other site
393126007557	active site
393126007558	phosphorylation site [posttranslational modification]
393126007559	metal binding site [ion binding]; metal-binding site
393126007560	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
393126007561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126007562	Coenzyme A binding pocket [chemical binding]; other site
393126007563	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
393126007564	esterase; Provisional; Region: PRK10566
393126007565	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
393126007566	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126007567	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
393126007568	motif II; other site
393126007569	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007570	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393126007571	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126007572	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126007573	hypothetical protein; Provisional; Region: PRK13673
393126007574	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
393126007575	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
393126007576	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
393126007577	Part of AAA domain; Region: AAA_19; pfam13245
393126007578	Family description; Region: UvrD_C_2; pfam13538
393126007579	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
393126007580	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
393126007581	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
393126007582	IDEAL domain; Region: IDEAL; pfam08858
393126007583	ComK protein; Region: ComK; cl11560
393126007584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
393126007585	AP2 domain; Region: AP2; pfam00847
393126007586	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
393126007587	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
393126007588	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
393126007589	Bacteriophage holin; Region: Phage_holin_1; pfam04531
393126007590	OPT oligopeptide transporter protein; Region: OPT; cl14607
393126007591	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
393126007592	Phage tail protein; Region: Sipho_tail; cl17486
393126007593	Phage-related tail protein [Function unknown]; Region: COG5283
393126007594	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
393126007595	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
393126007596	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
393126007597	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
393126007598	Phage terminase large subunit; Region: Terminase_3; cl12054
393126007599	Terminase-like family; Region: Terminase_6; pfam03237
393126007600	Terminase small subunit; Region: Terminase_2; cl01513
393126007601	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
393126007602	Recombination protein U; Region: RecU; cl01314
393126007603	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393126007604	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393126007605	dimer interface [polypeptide binding]; other site
393126007606	ssDNA binding site [nucleotide binding]; other site
393126007607	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126007608	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
393126007609	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126007610	S-adenosylmethionine binding site [chemical binding]; other site
393126007611	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
393126007612	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393126007613	Methyltransferase domain; Region: Methyltransf_25; pfam13649
393126007614	S-adenosylmethionine binding site [chemical binding]; other site
393126007615	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
393126007616	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
393126007617	Mitochondrial K+-H+ exchange-related; Region: Mit_KHE1; pfam10173
393126007618	ERF superfamily; Region: ERF; pfam04404
393126007619	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
393126007620	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
393126007621	Prophage antirepressor [Transcription]; Region: COG3617
393126007622	BRO family, N-terminal domain; Region: Bro-N; smart01040
393126007623	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645
393126007624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126007625	non-specific DNA binding site [nucleotide binding]; other site
393126007626	salt bridge; other site
393126007627	sequence-specific DNA binding site [nucleotide binding]; other site
393126007628	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126007629	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126007630	non-specific DNA binding site [nucleotide binding]; other site
393126007631	salt bridge; other site
393126007632	sequence-specific DNA binding site [nucleotide binding]; other site
393126007633	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
393126007634	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
393126007635	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
393126007636	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
393126007637	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
393126007638	catalytic residues [active]
393126007639	catalytic nucleophile [active]
393126007640	Presynaptic Site I dimer interface [polypeptide binding]; other site
393126007641	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
393126007642	Synaptic Flat tetramer interface [polypeptide binding]; other site
393126007643	Synaptic Site I dimer interface [polypeptide binding]; other site
393126007644	DNA binding site [nucleotide binding]
393126007645	Recombinase; Region: Recombinase; pfam07508
393126007646	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
393126007647	ComK protein; Region: ComK; cl11560
393126007648	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393126007649	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126007650	non-specific DNA binding site [nucleotide binding]; other site
393126007651	salt bridge; other site
393126007652	sequence-specific DNA binding site [nucleotide binding]; other site
393126007653	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
393126007654	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126007655	active site
393126007656	phosphorylation site [posttranslational modification]
393126007657	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126007658	active site
393126007659	P-loop; other site
393126007660	phosphorylation site [posttranslational modification]
393126007661	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126007662	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
393126007663	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
393126007664	putative substrate binding site [chemical binding]; other site
393126007665	putative ATP binding site [chemical binding]; other site
393126007666	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126007667	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393126007668	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126007669	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
393126007670	trimer interface [polypeptide binding]; other site
393126007671	active site
393126007672	G bulge; other site
393126007673	Uncharacterized conserved protein [Function unknown]; Region: COG1683
393126007674	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
393126007675	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393126007676	non-specific DNA interactions [nucleotide binding]; other site
393126007677	DNA binding site [nucleotide binding]
393126007678	sequence specific DNA binding site [nucleotide binding]; other site
393126007679	putative cAMP binding site [chemical binding]; other site
393126007680	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
393126007681	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
393126007682	substrate binding site [chemical binding]; other site
393126007683	ATP binding site [chemical binding]; other site
393126007684	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
393126007685	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393126007686	RNA binding surface [nucleotide binding]; other site
393126007687	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
393126007688	active site
393126007689	uracil binding [chemical binding]; other site
393126007690	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
393126007691	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
393126007692	active site
393126007693	non-prolyl cis peptide bond; other site
393126007694	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
393126007695	catalytic residues [active]
393126007696	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
393126007697	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
393126007698	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393126007699	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393126007700	Walker A/P-loop; other site
393126007701	ATP binding site [chemical binding]; other site
393126007702	Q-loop/lid; other site
393126007703	ABC transporter signature motif; other site
393126007704	Walker B; other site
393126007705	D-loop; other site
393126007706	H-loop/switch region; other site
393126007707	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393126007708	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007709	dimer interface [polypeptide binding]; other site
393126007710	conserved gate region; other site
393126007711	putative PBP binding loops; other site
393126007712	ABC-ATPase subunit interface; other site
393126007713	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393126007714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007715	dimer interface [polypeptide binding]; other site
393126007716	conserved gate region; other site
393126007717	putative PBP binding loops; other site
393126007718	ABC-ATPase subunit interface; other site
393126007719	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393126007720	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393126007721	substrate binding pocket [chemical binding]; other site
393126007722	membrane-bound complex binding site; other site
393126007723	hinge residues; other site
393126007724	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126007725	Coenzyme A binding pocket [chemical binding]; other site
393126007726	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393126007727	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393126007728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393126007729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393126007730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393126007731	dimerization interface [polypeptide binding]; other site
393126007732	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
393126007733	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393126007734	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
393126007735	active site
393126007736	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126007737	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126007738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126007739	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126007740	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
393126007741	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393126007742	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393126007743	active site
393126007744	trimer interface [polypeptide binding]; other site
393126007745	allosteric site; other site
393126007746	active site lid [active]
393126007747	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393126007748	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126007749	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007750	active site
393126007751	motif I; other site
393126007752	motif II; other site
393126007753	Predicted membrane protein [Function unknown]; Region: COG1511
393126007754	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393126007755	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
393126007756	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
393126007757	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
393126007758	Predicted transcriptional regulator [Transcription]; Region: COG1959
393126007759	Transcriptional regulator; Region: Rrf2; pfam02082
393126007760	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
393126007761	L-tyrosine decarboxylase; Provisional; Region: PRK13520
393126007762	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
393126007763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126007764	catalytic residue [active]
393126007765	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
393126007766	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126007767	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
393126007768	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393126007769	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393126007770	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393126007771	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
393126007772	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
393126007773	active site
393126007774	dimer interface [polypeptide binding]; other site
393126007775	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
393126007776	dimer interface [polypeptide binding]; other site
393126007777	active site
393126007778	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
393126007779	nudix motif; other site
393126007780	general stress protein 13; Validated; Region: PRK08059
393126007781	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393126007782	RNA binding site [nucleotide binding]; other site
393126007783	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
393126007784	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393126007785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126007786	homodimer interface [polypeptide binding]; other site
393126007787	catalytic residue [active]
393126007788	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
393126007789	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126007790	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126007791	Walker A/P-loop; other site
393126007792	ATP binding site [chemical binding]; other site
393126007793	Q-loop/lid; other site
393126007794	ABC transporter signature motif; other site
393126007795	Walker B; other site
393126007796	D-loop; other site
393126007797	H-loop/switch region; other site
393126007798	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126007799	active site
393126007800	P-loop; other site
393126007801	phosphorylation site [posttranslational modification]
393126007802	aspartate kinase; Reviewed; Region: PRK09034
393126007803	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
393126007804	putative catalytic residues [active]
393126007805	putative nucleotide binding site [chemical binding]; other site
393126007806	putative aspartate binding site [chemical binding]; other site
393126007807	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
393126007808	allosteric regulatory residue; other site
393126007809	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
393126007810	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
393126007811	active site
393126007812	drug efflux system protein MdtG; Provisional; Region: PRK09874
393126007813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126007814	putative substrate translocation pore; other site
393126007815	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
393126007816	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
393126007817	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
393126007818	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
393126007819	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
393126007820	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
393126007821	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
393126007822	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
393126007823	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
393126007824	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
393126007825	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
393126007826	CoenzymeA binding site [chemical binding]; other site
393126007827	subunit interaction site [polypeptide binding]; other site
393126007828	PHB binding site; other site
393126007829	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
393126007830	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
393126007831	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
393126007832	Cl- selectivity filter; other site
393126007833	Cl- binding residues [ion binding]; other site
393126007834	pore gating glutamate residue; other site
393126007835	dimer interface [polypeptide binding]; other site
393126007836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
393126007837	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
393126007838	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126007839	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
393126007840	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126007841	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126007842	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
393126007843	NADH(P)-binding; Region: NAD_binding_10; pfam13460
393126007844	NAD(P) binding site [chemical binding]; other site
393126007845	putative active site [active]
393126007846	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
393126007847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
393126007848	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126007849	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007850	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007851	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007852	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007853	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007854	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007855	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126007856	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
393126007857	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
393126007858	tetramer interfaces [polypeptide binding]; other site
393126007859	binuclear metal-binding site [ion binding]; other site
393126007860	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393126007861	Domain of unknown function DUF21; Region: DUF21; pfam01595
393126007862	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393126007863	Transporter associated domain; Region: CorC_HlyC; smart01091
393126007864	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393126007865	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126007866	Coenzyme A binding pocket [chemical binding]; other site
393126007867	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
393126007868	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007869	active site
393126007870	motif I; other site
393126007871	motif II; other site
393126007872	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126007873	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
393126007874	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
393126007875	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
393126007876	active site
393126007877	metal binding site [ion binding]; metal-binding site
393126007878	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
393126007879	Predicted permeases [General function prediction only]; Region: COG0730
393126007880	Predicted membrane protein [Function unknown]; Region: COG4272
393126007881	Uncharacterized conserved protein [Function unknown]; Region: COG1801
393126007882	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126007883	non-specific DNA binding site [nucleotide binding]; other site
393126007884	salt bridge; other site
393126007885	sequence-specific DNA binding site [nucleotide binding]; other site
393126007886	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
393126007887	FeS assembly protein SufB; Region: sufB; TIGR01980
393126007888	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
393126007889	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
393126007890	trimerization site [polypeptide binding]; other site
393126007891	active site
393126007892	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
393126007893	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
393126007894	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126007895	catalytic residue [active]
393126007896	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
393126007897	FeS assembly protein SufD; Region: sufD; TIGR01981
393126007898	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
393126007899	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
393126007900	Walker A/P-loop; other site
393126007901	ATP binding site [chemical binding]; other site
393126007902	Q-loop/lid; other site
393126007903	ABC transporter signature motif; other site
393126007904	Walker B; other site
393126007905	D-loop; other site
393126007906	H-loop/switch region; other site
393126007907	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
393126007908	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
393126007909	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126007910	ABC-ATPase subunit interface; other site
393126007911	putative PBP binding loops; other site
393126007912	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
393126007913	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
393126007914	Walker A/P-loop; other site
393126007915	ATP binding site [chemical binding]; other site
393126007916	Q-loop/lid; other site
393126007917	ABC transporter signature motif; other site
393126007918	Walker B; other site
393126007919	D-loop; other site
393126007920	H-loop/switch region; other site
393126007921	NIL domain; Region: NIL; pfam09383
393126007922	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126007923	dimer interface [polypeptide binding]; other site
393126007924	phosphorylation site [posttranslational modification]
393126007925	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126007926	ATP binding site [chemical binding]; other site
393126007927	Mg2+ binding site [ion binding]; other site
393126007928	G-X-G motif; other site
393126007929	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126007930	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126007931	active site
393126007932	phosphorylation site [posttranslational modification]
393126007933	intermolecular recognition site; other site
393126007934	dimerization interface [polypeptide binding]; other site
393126007935	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126007936	DNA binding site [nucleotide binding]
393126007937	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393126007938	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
393126007939	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126007940	catalytic residues [active]
393126007941	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
393126007942	lipoyl attachment site [posttranslational modification]; other site
393126007943	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
393126007944	ArsC family; Region: ArsC; pfam03960
393126007945	putative ArsC-like catalytic residues; other site
393126007946	putative TRX-like catalytic residues [active]
393126007947	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
393126007948	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
393126007949	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393126007950	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393126007951	Walker A/P-loop; other site
393126007952	ATP binding site [chemical binding]; other site
393126007953	Q-loop/lid; other site
393126007954	ABC transporter signature motif; other site
393126007955	Walker B; other site
393126007956	D-loop; other site
393126007957	H-loop/switch region; other site
393126007958	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393126007959	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393126007960	ABC-ATPase subunit  interface; other site
393126007961	dimer interface [polypeptide binding]; other site
393126007962	putative PBP binding regions; other site
393126007963	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
393126007964	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
393126007965	intersubunit interface [polypeptide binding]; other site
393126007966	Predicted esterase [General function prediction only]; Region: COG0627
393126007967	S-formylglutathione hydrolase; Region: PLN02442
393126007968	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
393126007969	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126007970	catalytic residue [active]
393126007971	SdpI/YhfL protein family; Region: SdpI; pfam13630
393126007972	CAT RNA binding domain; Region: CAT_RBD; smart01061
393126007973	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393126007974	PRD domain; Region: PRD; pfam00874
393126007975	PRD domain; Region: PRD; pfam00874
393126007976	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
393126007977	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
393126007978	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
393126007979	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
393126007980	Predicted transcriptional regulator [Transcription]; Region: COG2378
393126007981	HTH domain; Region: HTH_11; pfam08279
393126007982	WYL domain; Region: WYL; pfam13280
393126007983	Uncharacterized conserved protein [Function unknown]; Region: COG1434
393126007984	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
393126007985	putative active site [active]
393126007986	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393126007987	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
393126007988	active site
393126007989	catalytic site [active]
393126007990	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393126007991	putative metal binding site [ion binding]; other site
393126007992	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393126007993	putative metal binding site [ion binding]; other site
393126007994	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126007995	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393126007996	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393126007997	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
393126007998	active site
393126007999	catalytic site [active]
393126008000	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393126008001	putative metal binding site [ion binding]; other site
393126008002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126008003	non-specific DNA binding site [nucleotide binding]; other site
393126008004	salt bridge; other site
393126008005	sequence-specific DNA binding site [nucleotide binding]; other site
393126008006	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393126008007	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
393126008008	SmpB-tmRNA interface; other site
393126008009	ribonuclease R; Region: RNase_R; TIGR02063
393126008010	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
393126008011	RNB domain; Region: RNB; pfam00773
393126008012	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
393126008013	RNA binding site [nucleotide binding]; other site
393126008014	Esterase/lipase [General function prediction only]; Region: COG1647
393126008015	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393126008016	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
393126008017	Preprotein translocase SecG subunit; Region: SecG; cl09123
393126008018	Esterase/lipase [General function prediction only]; Region: COG1647
393126008019	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393126008020	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
393126008021	PGAP1-like protein; Region: PGAP1; pfam07819
393126008022	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
393126008023	enolase; Provisional; Region: eno; PRK00077
393126008024	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
393126008025	dimer interface [polypeptide binding]; other site
393126008026	metal binding site [ion binding]; metal-binding site
393126008027	substrate binding pocket [chemical binding]; other site
393126008028	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
393126008029	phosphoglyceromutase; Provisional; Region: PRK05434
393126008030	triosephosphate isomerase; Provisional; Region: PRK14567
393126008031	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
393126008032	substrate binding site [chemical binding]; other site
393126008033	dimer interface [polypeptide binding]; other site
393126008034	catalytic triad [active]
393126008035	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
393126008036	Phosphoglycerate kinase; Region: PGK; pfam00162
393126008037	substrate binding site [chemical binding]; other site
393126008038	hinge regions; other site
393126008039	ADP binding site [chemical binding]; other site
393126008040	catalytic site [active]
393126008041	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
393126008042	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
393126008043	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
393126008044	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393126008045	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393126008046	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
393126008047	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
393126008048	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
393126008049	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126008050	DNA binding site [nucleotide binding]
393126008051	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
393126008052	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
393126008053	active site
393126008054	dimer interface [polypeptide binding]; other site
393126008055	MMPL family; Region: MMPL; pfam03176
393126008056	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
393126008057	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126008058	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126008059	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
393126008060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
393126008061	Chitin binding domain; Region: Chitin_bind_3; pfam03067
393126008062	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
393126008063	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
393126008064	Interdomain contacts; other site
393126008065	Cytokine receptor motif; other site
393126008066	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393126008067	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393126008068	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393126008069	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393126008070	Clp protease; Region: CLP_protease; pfam00574
393126008071	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
393126008072	oligomer interface [polypeptide binding]; other site
393126008073	active site residues [active]
393126008074	amino acid transporter; Region: 2A0306; TIGR00909
393126008075	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
393126008076	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393126008077	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126008078	Substrate binding site [chemical binding]; other site
393126008079	Leucine rich repeat; Region: LRR_8; pfam13855
393126008080	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126008081	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
393126008082	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
393126008083	active site
393126008084	FMN binding site [chemical binding]; other site
393126008085	substrate binding site [chemical binding]; other site
393126008086	homotetramer interface [polypeptide binding]; other site
393126008087	catalytic residue [active]
393126008088	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
393126008089	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
393126008090	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
393126008091	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
393126008092	phosphate binding site [ion binding]; other site
393126008093	putative substrate binding pocket [chemical binding]; other site
393126008094	dimer interface [polypeptide binding]; other site
393126008095	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
393126008096	AAA domain; Region: AAA_18; pfam13238
393126008097	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
393126008098	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
393126008099	active site
393126008100	substrate binding site [chemical binding]; other site
393126008101	metal binding site [ion binding]; metal-binding site
393126008102	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
393126008103	active site
393126008104	catalytic residues [active]
393126008105	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
393126008106	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
393126008107	NAD binding site [chemical binding]; other site
393126008108	homodimer interface [polypeptide binding]; other site
393126008109	active site
393126008110	substrate binding site [chemical binding]; other site
393126008111	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
393126008112	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393126008113	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126008114	TPR repeat; Region: TPR_11; pfam13414
393126008115	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126008116	binding surface
393126008117	TPR motif; other site
393126008118	Tetratricopeptide repeat; Region: TPR_12; pfam13424
393126008119	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393126008120	binding surface
393126008121	TPR motif; other site
393126008122	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
393126008123	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393126008124	putative trimer interface [polypeptide binding]; other site
393126008125	putative CoA binding site [chemical binding]; other site
393126008126	pyrophosphatase PpaX; Provisional; Region: PRK13288
393126008127	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393126008128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126008129	motif II; other site
393126008130	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
393126008131	HPr kinase/phosphorylase; Provisional; Region: PRK05428
393126008132	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
393126008133	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
393126008134	Hpr binding site; other site
393126008135	active site
393126008136	homohexamer subunit interaction site [polypeptide binding]; other site
393126008137	Predicted membrane protein [Function unknown]; Region: COG1950
393126008138	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
393126008139	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
393126008140	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393126008141	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393126008142	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393126008143	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393126008144	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
393126008145	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393126008146	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393126008147	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
393126008148	excinuclease ABC subunit B; Provisional; Region: PRK05298
393126008149	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126008150	ATP binding site [chemical binding]; other site
393126008151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126008152	nucleotide binding region [chemical binding]; other site
393126008153	ATP-binding site [chemical binding]; other site
393126008154	Ultra-violet resistance protein B; Region: UvrB; pfam12344
393126008155	UvrB/uvrC motif; Region: UVR; pfam02151
393126008156	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
393126008157	HD containing hydrolase-like enzyme; Region: HD_2; pfam12917
393126008158	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126008159	dimerization interface [polypeptide binding]; other site
393126008160	putative DNA binding site [nucleotide binding]; other site
393126008161	putative Zn2+ binding site [ion binding]; other site
393126008162	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
393126008163	PhoU domain; Region: PhoU; pfam01895
393126008164	PhoU domain; Region: PhoU; pfam01895
393126008165	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
393126008166	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
393126008167	Walker A/P-loop; other site
393126008168	ATP binding site [chemical binding]; other site
393126008169	Q-loop/lid; other site
393126008170	ABC transporter signature motif; other site
393126008171	Walker B; other site
393126008172	D-loop; other site
393126008173	H-loop/switch region; other site
393126008174	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
393126008175	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
393126008176	Walker A/P-loop; other site
393126008177	ATP binding site [chemical binding]; other site
393126008178	Q-loop/lid; other site
393126008179	ABC transporter signature motif; other site
393126008180	Walker B; other site
393126008181	D-loop; other site
393126008182	H-loop/switch region; other site
393126008183	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
393126008184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126008185	dimer interface [polypeptide binding]; other site
393126008186	conserved gate region; other site
393126008187	putative PBP binding loops; other site
393126008188	ABC-ATPase subunit interface; other site
393126008189	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
393126008190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126008191	dimer interface [polypeptide binding]; other site
393126008192	conserved gate region; other site
393126008193	putative PBP binding loops; other site
393126008194	ABC-ATPase subunit interface; other site
393126008195	PBP superfamily domain; Region: PBP_like_2; cl17296
393126008196	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
393126008197	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
393126008198	HAMP domain; Region: HAMP; pfam00672
393126008199	dimerization interface [polypeptide binding]; other site
393126008200	PAS domain; Region: PAS; smart00091
393126008201	putative active site [active]
393126008202	heme pocket [chemical binding]; other site
393126008203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126008204	dimer interface [polypeptide binding]; other site
393126008205	phosphorylation site [posttranslational modification]
393126008206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126008207	ATP binding site [chemical binding]; other site
393126008208	Mg2+ binding site [ion binding]; other site
393126008209	G-X-G motif; other site
393126008210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126008211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126008212	active site
393126008213	phosphorylation site [posttranslational modification]
393126008214	intermolecular recognition site; other site
393126008215	dimerization interface [polypeptide binding]; other site
393126008216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126008217	DNA binding site [nucleotide binding]
393126008218	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
393126008219	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
393126008220	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
393126008221	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
393126008222	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
393126008223	putative active site [active]
393126008224	catalytic site [active]
393126008225	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
393126008226	putative active site [active]
393126008227	catalytic site [active]
393126008228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
393126008229	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
393126008230	Peptidase family M23; Region: Peptidase_M23; pfam01551
393126008231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
393126008232	NlpC/P60 family; Region: NLPC_P60; pfam00877
393126008233	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
393126008234	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
393126008235	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
393126008236	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126008237	Walker A/P-loop; other site
393126008238	ATP binding site [chemical binding]; other site
393126008239	Q-loop/lid; other site
393126008240	ABC transporter signature motif; other site
393126008241	Walker B; other site
393126008242	D-loop; other site
393126008243	H-loop/switch region; other site
393126008244	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393126008245	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126008246	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393126008247	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393126008248	peptide chain release factor 2; Validated; Region: prfB; PRK00578
393126008249	This domain is found in peptide chain release factors; Region: PCRF; smart00937
393126008250	RF-1 domain; Region: RF-1; pfam00472
393126008251	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
393126008252	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
393126008253	nucleotide binding region [chemical binding]; other site
393126008254	helicase superfamily c-terminal domain; Region: HELICc; smart00490
393126008255	ATP-binding site [chemical binding]; other site
393126008256	SEC-C motif; Region: SEC-C; pfam02810
393126008257	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
393126008258	30S subunit binding site; other site
393126008259	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
393126008260	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126008261	active site
393126008262	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
393126008263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126008264	ATP binding site [chemical binding]; other site
393126008265	putative Mg++ binding site [ion binding]; other site
393126008266	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126008267	nucleotide binding region [chemical binding]; other site
393126008268	ATP-binding site [chemical binding]; other site
393126008269	EDD domain protein, DegV family; Region: DegV; TIGR00762
393126008270	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393126008271	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
393126008272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126008273	active site
393126008274	phosphorylation site [posttranslational modification]
393126008275	intermolecular recognition site; other site
393126008276	dimerization interface [polypeptide binding]; other site
393126008277	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
393126008278	DNA binding residues [nucleotide binding]
393126008279	dimerization interface [polypeptide binding]; other site
393126008280	Uncharacterized conserved protein [Function unknown]; Region: COG1739
393126008281	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
393126008282	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
393126008283	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393126008284	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393126008285	Transcriptional regulator [Transcription]; Region: LytR; COG1316
393126008286	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
393126008287	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
393126008288	Mg++ binding site [ion binding]; other site
393126008289	putative catalytic motif [active]
393126008290	substrate binding site [chemical binding]; other site
393126008291	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
393126008292	metal binding site [ion binding]; metal-binding site
393126008293	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
393126008294	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
393126008295	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008296	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008297	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
393126008298	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393126008299	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393126008300	dimer interface [polypeptide binding]; other site
393126008301	ssDNA binding site [nucleotide binding]; other site
393126008302	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393126008303	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
393126008304	rod shape-determining protein Mbl; Provisional; Region: PRK13928
393126008305	MreB and similar proteins; Region: MreB_like; cd10225
393126008306	nucleotide binding site [chemical binding]; other site
393126008307	Mg binding site [ion binding]; other site
393126008308	putative protofilament interaction site [polypeptide binding]; other site
393126008309	RodZ interaction site [polypeptide binding]; other site
393126008310	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
393126008311	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
393126008312	hinge; other site
393126008313	active site
393126008314	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
393126008315	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
393126008316	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
393126008317	gamma subunit interface [polypeptide binding]; other site
393126008318	epsilon subunit interface [polypeptide binding]; other site
393126008319	LBP interface [polypeptide binding]; other site
393126008320	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
393126008321	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393126008322	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
393126008323	alpha subunit interaction interface [polypeptide binding]; other site
393126008324	Walker A motif; other site
393126008325	ATP binding site [chemical binding]; other site
393126008326	Walker B motif; other site
393126008327	inhibitor binding site; inhibition site
393126008328	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393126008329	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
393126008330	core domain interface [polypeptide binding]; other site
393126008331	delta subunit interface [polypeptide binding]; other site
393126008332	epsilon subunit interface [polypeptide binding]; other site
393126008333	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
393126008334	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393126008335	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
393126008336	beta subunit interaction interface [polypeptide binding]; other site
393126008337	Walker A motif; other site
393126008338	ATP binding site [chemical binding]; other site
393126008339	Walker B motif; other site
393126008340	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393126008341	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
393126008342	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
393126008343	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
393126008344	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
393126008345	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
393126008346	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
393126008347	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
393126008348	ATP synthase I chain; Region: ATP_synt_I; pfam03899
393126008349	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
393126008350	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
393126008351	active site
393126008352	homodimer interface [polypeptide binding]; other site
393126008353	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393126008354	active site
393126008355	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
393126008356	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
393126008357	dimer interface [polypeptide binding]; other site
393126008358	active site
393126008359	glycine-pyridoxal phosphate binding site [chemical binding]; other site
393126008360	folate binding site [chemical binding]; other site
393126008361	Low molecular weight phosphatase family; Region: LMWPc; cd00115
393126008362	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393126008363	active site
393126008364	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
393126008365	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
393126008366	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
393126008367	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126008368	S-adenosylmethionine binding site [chemical binding]; other site
393126008369	peptide chain release factor 1; Validated; Region: prfA; PRK00591
393126008370	This domain is found in peptide chain release factors; Region: PCRF; smart00937
393126008371	RF-1 domain; Region: RF-1; pfam00472
393126008372	thymidine kinase; Provisional; Region: PRK04296
393126008373	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393126008374	ATP binding site [chemical binding]; other site
393126008375	Walker A motif; other site
393126008376	Walker B motif; other site
393126008377	homoserine kinase; Provisional; Region: PRK01212
393126008378	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393126008379	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393126008380	threonine synthase; Reviewed; Region: PRK06721
393126008381	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
393126008382	homodimer interface [polypeptide binding]; other site
393126008383	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126008384	catalytic residue [active]
393126008385	homoserine dehydrogenase; Provisional; Region: PRK06349
393126008386	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
393126008387	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
393126008388	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
393126008389	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
393126008390	Predicted membrane protein [Function unknown]; Region: COG2246
393126008391	GtrA-like protein; Region: GtrA; pfam04138
393126008392	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
393126008393	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
393126008394	Ligand binding site; other site
393126008395	Putative Catalytic site; other site
393126008396	DXD motif; other site
393126008397	transcription termination factor Rho; Provisional; Region: rho; PRK09376
393126008398	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
393126008399	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
393126008400	multimer interface [polypeptide binding]; other site
393126008401	Walker A motif; other site
393126008402	ATP binding site [chemical binding]; other site
393126008403	Walker B motif; other site
393126008404	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
393126008405	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
393126008406	hinge; other site
393126008407	active site
393126008408	Predicted integral membrane protein [Function unknown]; Region: COG0392
393126008409	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
393126008410	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
393126008411	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
393126008412	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
393126008413	putative ADP-binding pocket [chemical binding]; other site
393126008414	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
393126008415	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393126008416	intersubunit interface [polypeptide binding]; other site
393126008417	active site
393126008418	zinc binding site [ion binding]; other site
393126008419	Na+ binding site [ion binding]; other site
393126008420	putative lipid kinase; Reviewed; Region: PRK13055
393126008421	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393126008422	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
393126008423	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
393126008424	amidase catalytic site [active]
393126008425	Zn binding residues [ion binding]; other site
393126008426	substrate binding site [chemical binding]; other site
393126008427	SH3-like domain; Region: SH3_8; pfam13457
393126008428	SH3-like domain; Region: SH3_8; pfam13457
393126008429	SH3-like domain; Region: SH3_8; pfam13457
393126008430	SH3-like domain; Region: SH3_8; pfam13457
393126008431	CTP synthetase; Validated; Region: pyrG; PRK05380
393126008432	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
393126008433	Catalytic site [active]
393126008434	active site
393126008435	UTP binding site [chemical binding]; other site
393126008436	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
393126008437	active site
393126008438	putative oxyanion hole; other site
393126008439	catalytic triad [active]
393126008440	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
393126008441	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
393126008442	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
393126008443	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
393126008444	active site
393126008445	HIGH motif; other site
393126008446	KMSK motif region; other site
393126008447	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
393126008448	tRNA binding surface [nucleotide binding]; other site
393126008449	anticodon binding site; other site
393126008450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
393126008451	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
393126008452	Peptidase family M50; Region: Peptidase_M50; pfam02163
393126008453	active site
393126008454	putative substrate binding region [chemical binding]; other site
393126008455	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
393126008456	active site 1 [active]
393126008457	dimer interface [polypeptide binding]; other site
393126008458	hexamer interface [polypeptide binding]; other site
393126008459	active site 2 [active]
393126008460	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
393126008461	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126008462	Zn2+ binding site [ion binding]; other site
393126008463	Mg2+ binding site [ion binding]; other site
393126008464	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393126008465	conserved hypothetical protein TIGR01655; Region: yxeA_fam
393126008466	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393126008467	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393126008468	peptide binding site [polypeptide binding]; other site
393126008469	Predicted integral membrane protein [Function unknown]; Region: COG5658
393126008470	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
393126008471	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
393126008472	catalytic triad [active]
393126008473	metal binding site [ion binding]; metal-binding site
393126008474	conserved cis-peptide bond; other site
393126008475	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
393126008476	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
393126008477	folate binding site [chemical binding]; other site
393126008478	NADP+ binding site [chemical binding]; other site
393126008479	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
393126008480	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
393126008481	putative NAD(P) binding site [chemical binding]; other site
393126008482	dimer interface [polypeptide binding]; other site
393126008483	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
393126008484	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393126008485	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393126008486	Collagen binding domain; Region: Collagen_bind; pfam05737
393126008487	Collagen binding domain; Region: Collagen_bind; pfam05737
393126008488	Collagen binding domain; Region: Collagen_bind; pfam05737
393126008489	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008490	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008491	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008492	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008493	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008494	Cna protein B-type domain; Region: Cna_B; pfam05738
393126008495	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126008496	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126008497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126008498	active site
393126008499	motif I; other site
393126008500	motif II; other site
393126008501	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
393126008502	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393126008503	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393126008504	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126008505	Walker A/P-loop; other site
393126008506	ATP binding site [chemical binding]; other site
393126008507	Q-loop/lid; other site
393126008508	ABC transporter signature motif; other site
393126008509	Walker B; other site
393126008510	D-loop; other site
393126008511	H-loop/switch region; other site
393126008512	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393126008513	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393126008514	FtsX-like permease family; Region: FtsX; pfam02687
393126008515	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393126008516	dimerization interface [polypeptide binding]; other site
393126008517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126008518	dimer interface [polypeptide binding]; other site
393126008519	phosphorylation site [posttranslational modification]
393126008520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126008521	ATP binding site [chemical binding]; other site
393126008522	Mg2+ binding site [ion binding]; other site
393126008523	G-X-G motif; other site
393126008524	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126008525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126008526	active site
393126008527	phosphorylation site [posttranslational modification]
393126008528	intermolecular recognition site; other site
393126008529	dimerization interface [polypeptide binding]; other site
393126008530	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126008531	DNA binding site [nucleotide binding]
393126008532	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
393126008533	Uncharacterized conserved protein [Function unknown]; Region: COG2427
393126008534	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
393126008535	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
393126008536	catalytic loop [active]
393126008537	iron binding site [ion binding]; other site
393126008538	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
393126008539	4Fe-4S binding domain; Region: Fer4; pfam00037
393126008540	4Fe-4S binding domain; Region: Fer4; pfam00037
393126008541	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
393126008542	[4Fe-4S] binding site [ion binding]; other site
393126008543	molybdopterin cofactor binding site; other site
393126008544	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
393126008545	molybdopterin cofactor binding site; other site
393126008546	Uncharacterized conserved protein [Function unknown]; Region: COG1912
393126008547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126008548	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126008549	putative substrate translocation pore; other site
393126008550	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126008551	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126008552	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
393126008553	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
393126008554	Walker A motif; other site
393126008555	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126008556	SH3-like domain; Region: SH3_8; pfam13457
393126008557	SH3-like domain; Region: SH3_8; pfam13457
393126008558	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126008559	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126008560	active site
393126008561	catalytic tetrad [active]
393126008562	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126008563	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126008564	DNA binding residues [nucleotide binding]
393126008565	putative dimer interface [polypeptide binding]; other site
393126008566	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
393126008567	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
393126008568	23S rRNA interface [nucleotide binding]; other site
393126008569	L3 interface [polypeptide binding]; other site
393126008570	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
393126008571	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
393126008572	dimerization interface 3.5A [polypeptide binding]; other site
393126008573	active site
393126008574	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
393126008575	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
393126008576	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393126008577	Walker A/P-loop; other site
393126008578	ATP binding site [chemical binding]; other site
393126008579	Q-loop/lid; other site
393126008580	ABC transporter signature motif; other site
393126008581	Walker B; other site
393126008582	D-loop; other site
393126008583	H-loop/switch region; other site
393126008584	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
393126008585	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393126008586	Walker A/P-loop; other site
393126008587	ATP binding site [chemical binding]; other site
393126008588	Q-loop/lid; other site
393126008589	ABC transporter signature motif; other site
393126008590	Walker B; other site
393126008591	D-loop; other site
393126008592	H-loop/switch region; other site
393126008593	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
393126008594	MgtC family; Region: MgtC; pfam02308
393126008595	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
393126008596	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
393126008597	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
393126008598	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
393126008599	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
393126008600	alphaNTD - beta interaction site [polypeptide binding]; other site
393126008601	alphaNTD homodimer interface [polypeptide binding]; other site
393126008602	alphaNTD - beta' interaction site [polypeptide binding]; other site
393126008603	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
393126008604	30S ribosomal protein S11; Validated; Region: PRK05309
393126008605	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
393126008606	30S ribosomal protein S13; Region: bact_S13; TIGR03631
393126008607	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
393126008608	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
393126008609	rRNA binding site [nucleotide binding]; other site
393126008610	predicted 30S ribosome binding site; other site
393126008611	adenylate kinase; Reviewed; Region: adk; PRK00279
393126008612	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
393126008613	AMP-binding site [chemical binding]; other site
393126008614	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
393126008615	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
393126008616	SecY translocase; Region: SecY; pfam00344
393126008617	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
393126008618	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
393126008619	23S rRNA binding site [nucleotide binding]; other site
393126008620	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
393126008621	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
393126008622	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
393126008623	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
393126008624	5S rRNA interface [nucleotide binding]; other site
393126008625	L27 interface [polypeptide binding]; other site
393126008626	23S rRNA interface [nucleotide binding]; other site
393126008627	L5 interface [polypeptide binding]; other site
393126008628	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
393126008629	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
393126008630	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
393126008631	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
393126008632	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
393126008633	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
393126008634	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
393126008635	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
393126008636	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
393126008637	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
393126008638	RNA binding site [nucleotide binding]; other site
393126008639	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
393126008640	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
393126008641	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
393126008642	23S rRNA interface [nucleotide binding]; other site
393126008643	putative translocon interaction site; other site
393126008644	signal recognition particle (SRP54) interaction site; other site
393126008645	L23 interface [polypeptide binding]; other site
393126008646	trigger factor interaction site; other site
393126008647	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
393126008648	23S rRNA interface [nucleotide binding]; other site
393126008649	5S rRNA interface [nucleotide binding]; other site
393126008650	putative antibiotic binding site [chemical binding]; other site
393126008651	L25 interface [polypeptide binding]; other site
393126008652	L27 interface [polypeptide binding]; other site
393126008653	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
393126008654	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
393126008655	G-X-X-G motif; other site
393126008656	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
393126008657	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
393126008658	putative translocon binding site; other site
393126008659	protein-rRNA interface [nucleotide binding]; other site
393126008660	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
393126008661	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
393126008662	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
393126008663	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
393126008664	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
393126008665	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
393126008666	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
393126008667	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
393126008668	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
393126008669	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
393126008670	UbiA prenyltransferase family; Region: UbiA; pfam01040
393126008671	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
393126008672	ApbE family; Region: ApbE; pfam02424
393126008673	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
393126008674	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
393126008675	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
393126008676	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
393126008677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393126008678	Predicted membrane protein [Function unknown]; Region: COG2259
393126008679	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
393126008680	Predicted membrane protein [Function unknown]; Region: COG4769
393126008681	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393126008682	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393126008683	substrate binding pocket [chemical binding]; other site
393126008684	chain length determination region; other site
393126008685	substrate-Mg2+ binding site; other site
393126008686	catalytic residues [active]
393126008687	aspartate-rich region 1; other site
393126008688	active site lid residues [active]
393126008689	aspartate-rich region 2; other site
393126008690	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
393126008691	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
393126008692	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
393126008693	active site
393126008694	metal binding site [ion binding]; metal-binding site
393126008695	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
393126008696	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
393126008697	hypothetical protein; Provisional; Region: PRK02947
393126008698	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126008699	putative active site [active]
393126008700	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
393126008701	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
393126008702	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
393126008703	active site
393126008704	substrate binding pocket [chemical binding]; other site
393126008705	homodimer interaction site [polypeptide binding]; other site
393126008706	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
393126008707	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
393126008708	active site
393126008709	P-loop; other site
393126008710	phosphorylation site [posttranslational modification]
393126008711	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126008712	active site
393126008713	phosphorylation site [posttranslational modification]
393126008714	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126008715	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126008716	PRD domain; Region: PRD; pfam00874
393126008717	PRD domain; Region: PRD; pfam00874
393126008718	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126008719	active site
393126008720	P-loop; other site
393126008721	phosphorylation site [posttranslational modification]
393126008722	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126008723	active site
393126008724	phosphorylation site [posttranslational modification]
393126008725	elongation factor Tu; Reviewed; Region: PRK00049
393126008726	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
393126008727	G1 box; other site
393126008728	GEF interaction site [polypeptide binding]; other site
393126008729	GTP/Mg2+ binding site [chemical binding]; other site
393126008730	Switch I region; other site
393126008731	G2 box; other site
393126008732	G3 box; other site
393126008733	Switch II region; other site
393126008734	G4 box; other site
393126008735	G5 box; other site
393126008736	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
393126008737	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
393126008738	Antibiotic Binding Site [chemical binding]; other site
393126008739	elongation factor G; Reviewed; Region: PRK00007
393126008740	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
393126008741	G1 box; other site
393126008742	putative GEF interaction site [polypeptide binding]; other site
393126008743	GTP/Mg2+ binding site [chemical binding]; other site
393126008744	Switch I region; other site
393126008745	G2 box; other site
393126008746	G3 box; other site
393126008747	Switch II region; other site
393126008748	G4 box; other site
393126008749	G5 box; other site
393126008750	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
393126008751	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
393126008752	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
393126008753	30S ribosomal protein S7; Validated; Region: PRK05302
393126008754	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
393126008755	S17 interaction site [polypeptide binding]; other site
393126008756	S8 interaction site; other site
393126008757	16S rRNA interaction site [nucleotide binding]; other site
393126008758	streptomycin interaction site [chemical binding]; other site
393126008759	23S rRNA interaction site [nucleotide binding]; other site
393126008760	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
393126008761	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
393126008762	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393126008763	Zn2+ binding site [ion binding]; other site
393126008764	Mg2+ binding site [ion binding]; other site
393126008765	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
393126008766	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126008767	Coenzyme A binding pocket [chemical binding]; other site
393126008768	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126008769	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126008770	substrate binding site [chemical binding]; other site
393126008771	hexamer interface [polypeptide binding]; other site
393126008772	metal binding site [ion binding]; metal-binding site
393126008773	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393126008774	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393126008775	TPP-binding site [chemical binding]; other site
393126008776	dimer interface [polypeptide binding]; other site
393126008777	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393126008778	PYR/PP interface [polypeptide binding]; other site
393126008779	dimer interface [polypeptide binding]; other site
393126008780	TPP binding site [chemical binding]; other site
393126008781	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393126008782	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393126008783	substrate binding site [chemical binding]; other site
393126008784	hexamer interface [polypeptide binding]; other site
393126008785	metal binding site [ion binding]; metal-binding site
393126008786	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393126008787	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393126008788	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
393126008789	putative NAD(P) binding site [chemical binding]; other site
393126008790	catalytic Zn binding site [ion binding]; other site
393126008791	structural Zn binding site [ion binding]; other site
393126008792	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393126008793	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
393126008794	putative NAD(P) binding site [chemical binding]; other site
393126008795	catalytic Zn binding site [ion binding]; other site
393126008796	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393126008797	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393126008798	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393126008799	active site
393126008800	P-loop; other site
393126008801	phosphorylation site [posttranslational modification]
393126008802	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126008803	active site
393126008804	phosphorylation site [posttranslational modification]
393126008805	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126008806	PRD domain; Region: PRD; pfam00874
393126008807	PRD domain; Region: PRD; pfam00874
393126008808	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126008809	active site
393126008810	P-loop; other site
393126008811	phosphorylation site [posttranslational modification]
393126008812	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126008813	active site
393126008814	phosphorylation site [posttranslational modification]
393126008815	Predicted membrane protein [Function unknown]; Region: COG4905
393126008816	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
393126008817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
393126008818	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
393126008819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393126008820	active site
393126008821	Helix-turn-helix domain; Region: HTH_18; pfam12833
393126008822	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393126008823	Ligand Binding Site [chemical binding]; other site
393126008824	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
393126008825	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
393126008826	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
393126008827	active site
393126008828	DNA binding site [nucleotide binding]
393126008829	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
393126008830	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
393126008831	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
393126008832	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
393126008833	active site
393126008834	DNA binding site [nucleotide binding]
393126008835	Int/Topo IB signature motif; other site
393126008836	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
393126008837	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
393126008838	active site
393126008839	DNA binding site [nucleotide binding]
393126008840	Int/Topo IB signature motif; other site
393126008841	Chibby, a nuclear inhibitor of Wnt/beta-catenin mediated transcription, and similar proteins; Region: Cby_like; cd07429
393126008842	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
393126008843	DNA polymerase IV; Reviewed; Region: PRK03103
393126008844	active site
393126008845	DNA binding site [nucleotide binding]
393126008846	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
393126008847	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393126008848	Low molecular weight phosphatase family; Region: LMWPc; cd00115
393126008849	active site
393126008850	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
393126008851	Sodium Bile acid symporter family; Region: SBF; cl17470
393126008852	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
393126008853	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
393126008854	P loop; other site
393126008855	Nucleotide binding site [chemical binding]; other site
393126008856	DTAP/Switch II; other site
393126008857	Switch I; other site
393126008858	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
393126008859	P loop; other site
393126008860	Nucleotide binding site [chemical binding]; other site
393126008861	DTAP/Switch II; other site
393126008862	Switch I; other site
393126008863	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
393126008864	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393126008865	dimerization interface [polypeptide binding]; other site
393126008866	putative DNA binding site [nucleotide binding]; other site
393126008867	putative Zn2+ binding site [ion binding]; other site
393126008868	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393126008869	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393126008870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393126008871	active site
393126008872	phosphorylation site [posttranslational modification]
393126008873	intermolecular recognition site; other site
393126008874	dimerization interface [polypeptide binding]; other site
393126008875	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393126008876	DNA binding site [nucleotide binding]
393126008877	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
393126008878	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
393126008879	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
393126008880	Ligand Binding Site [chemical binding]; other site
393126008881	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
393126008882	GAF domain; Region: GAF_3; pfam13492
393126008883	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393126008884	dimer interface [polypeptide binding]; other site
393126008885	phosphorylation site [posttranslational modification]
393126008886	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393126008887	ATP binding site [chemical binding]; other site
393126008888	Mg2+ binding site [ion binding]; other site
393126008889	G-X-G motif; other site
393126008890	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
393126008891	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
393126008892	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126008893	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
393126008894	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126008895	active site
393126008896	P-loop; other site
393126008897	phosphorylation site [posttranslational modification]
393126008898	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126008899	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126008900	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126008901	methionine cluster; other site
393126008902	active site
393126008903	phosphorylation site [posttranslational modification]
393126008904	metal binding site [ion binding]; metal-binding site
393126008905	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393126008906	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393126008907	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
393126008908	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
393126008909	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393126008910	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393126008911	Soluble P-type ATPase [General function prediction only]; Region: COG4087
393126008912	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393126008913	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126008914	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126008915	autolysin; Reviewed; Region: PRK06347
393126008916	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393126008917	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008918	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008919	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008920	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393126008921	Protein of unknown function (DUF970); Region: DUF970; pfam06153
393126008922	thymidylate kinase; Validated; Region: tmk; PRK00698
393126008923	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
393126008924	TMP-binding site; other site
393126008925	ATP-binding site [chemical binding]; other site
393126008926	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
393126008927	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
393126008928	homodimer interface [polypeptide binding]; other site
393126008929	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126008930	catalytic residue [active]
393126008931	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
393126008932	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
393126008933	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393126008934	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393126008935	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
393126008936	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
393126008937	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126008938	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126008939	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126008940	putative active site [active]
393126008941	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393126008942	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126008943	active site
393126008944	motif I; other site
393126008945	motif II; other site
393126008946	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393126008947	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393126008948	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393126008949	active site
393126008950	catalytic tetrad [active]
393126008951	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
393126008952	recombination protein RecR; Reviewed; Region: recR; PRK00076
393126008953	RecR protein; Region: RecR; pfam02132
393126008954	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
393126008955	putative active site [active]
393126008956	putative metal-binding site [ion binding]; other site
393126008957	tetramer interface [polypeptide binding]; other site
393126008958	hypothetical protein; Validated; Region: PRK00153
393126008959	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
393126008960	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393126008961	Walker A motif; other site
393126008962	ATP binding site [chemical binding]; other site
393126008963	Walker B motif; other site
393126008964	arginine finger; other site
393126008965	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
393126008966	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
393126008967	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
393126008968	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126008969	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126008970	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
393126008971	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
393126008972	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
393126008973	N- and C-terminal domain interface [polypeptide binding]; other site
393126008974	active site
393126008975	catalytic site [active]
393126008976	metal binding site [ion binding]; metal-binding site
393126008977	carbohydrate binding site [chemical binding]; other site
393126008978	ATP binding site [chemical binding]; other site
393126008979	SH3-like domain; Region: SH3_8; pfam13457
393126008980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
393126008981	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
393126008982	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126008983	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
393126008984	Walker A/P-loop; other site
393126008985	ATP binding site [chemical binding]; other site
393126008986	Q-loop/lid; other site
393126008987	ABC transporter signature motif; other site
393126008988	Walker B; other site
393126008989	D-loop; other site
393126008990	H-loop/switch region; other site
393126008991	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
393126008992	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126008993	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126008994	Walker A/P-loop; other site
393126008995	ATP binding site [chemical binding]; other site
393126008996	Q-loop/lid; other site
393126008997	ABC transporter signature motif; other site
393126008998	Walker B; other site
393126008999	D-loop; other site
393126009000	H-loop/switch region; other site
393126009001	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
393126009002	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
393126009003	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
393126009004	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
393126009005	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
393126009006	nucleoside/Zn binding site; other site
393126009007	dimer interface [polypeptide binding]; other site
393126009008	catalytic motif [active]
393126009009	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
393126009010	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
393126009011	active site
393126009012	acyl-activating enzyme (AAE) consensus motif; other site
393126009013	putative CoA binding site [chemical binding]; other site
393126009014	AMP binding site [chemical binding]; other site
393126009015	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393126009016	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393126009017	active site
393126009018	trimer interface [polypeptide binding]; other site
393126009019	allosteric site; other site
393126009020	active site lid [active]
393126009021	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393126009022	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
393126009023	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393126009024	DNA binding residues [nucleotide binding]
393126009025	drug binding residues [chemical binding]; other site
393126009026	dimer interface [polypeptide binding]; other site
393126009027	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393126009028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393126009029	Coenzyme A binding pocket [chemical binding]; other site
393126009030	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393126009031	dimer interface [polypeptide binding]; other site
393126009032	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393126009033	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393126009034	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393126009035	MarR family; Region: MarR; pfam01047
393126009036	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
393126009037	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
393126009038	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393126009039	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393126009040	DNA binding residues [nucleotide binding]
393126009041	putative dimer interface [polypeptide binding]; other site
393126009042	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
393126009043	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
393126009044	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126009045	active site
393126009046	motif I; other site
393126009047	motif II; other site
393126009048	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126009049	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126009050	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126009051	putative active site [active]
393126009052	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
393126009053	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126009054	active site
393126009055	phosphorylation site [posttranslational modification]
393126009056	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393126009057	active site
393126009058	P-loop; other site
393126009059	phosphorylation site [posttranslational modification]
393126009060	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393126009061	alpha-mannosidase; Provisional; Region: PRK09819
393126009062	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393126009063	active site
393126009064	metal binding site [ion binding]; metal-binding site
393126009065	catalytic site [active]
393126009066	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
393126009067	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
393126009068	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
393126009069	active site
393126009070	homodimer interface [polypeptide binding]; other site
393126009071	catalytic site [active]
393126009072	glycerate kinase; Region: TIGR00045
393126009073	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126009074	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126009075	DNA binding site [nucleotide binding]
393126009076	domain linker motif; other site
393126009077	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
393126009078	putative dimerization interface [polypeptide binding]; other site
393126009079	putative ligand binding site [chemical binding]; other site
393126009080	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393126009081	Domain of unknown function DUF21; Region: DUF21; pfam01595
393126009082	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393126009083	Transporter associated domain; Region: CorC_HlyC; pfam03471
393126009084	NAD-dependent deacetylase; Provisional; Region: PRK00481
393126009085	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
393126009086	NAD+ binding site [chemical binding]; other site
393126009087	substrate binding site [chemical binding]; other site
393126009088	putative Zn binding site [ion binding]; other site
393126009089	Pathogenicity locus; Region: Cdd1; pfam11731
393126009090	drug efflux system protein MdtG; Provisional; Region: PRK09874
393126009091	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009092	putative substrate translocation pore; other site
393126009093	Src Homology 3 domain superfamily; Region: SH3; cl17036
393126009094	Variant SH3 domain; Region: SH3_2; pfam07653
393126009095	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
393126009096	active site
393126009097	intersubunit interactions; other site
393126009098	catalytic residue [active]
393126009099	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393126009100	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393126009101	ligand binding site [chemical binding]; other site
393126009102	flexible hinge region; other site
393126009103	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393126009104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126009105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126009106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126009107	Walker A/P-loop; other site
393126009108	ATP binding site [chemical binding]; other site
393126009109	Q-loop/lid; other site
393126009110	ABC transporter signature motif; other site
393126009111	Walker B; other site
393126009112	D-loop; other site
393126009113	H-loop/switch region; other site
393126009114	TfoX C-terminal domain; Region: TfoX_C; pfam04994
393126009115	seryl-tRNA synthetase; Provisional; Region: PRK05431
393126009116	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
393126009117	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
393126009118	dimer interface [polypeptide binding]; other site
393126009119	active site
393126009120	motif 1; other site
393126009121	motif 2; other site
393126009122	motif 3; other site
393126009123	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
393126009124	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
393126009125	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
393126009126	Glutamine amidotransferase class-I; Region: GATase; pfam00117
393126009127	glutamine binding [chemical binding]; other site
393126009128	catalytic triad [active]
393126009129	chorismate binding enzyme; Region: Chorismate_bind; cl10555
393126009130	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
393126009131	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
393126009132	substrate-cofactor binding pocket; other site
393126009133	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
393126009134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393126009135	catalytic residue [active]
393126009136	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126009137	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126009138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126009139	Walker A/P-loop; other site
393126009140	ATP binding site [chemical binding]; other site
393126009141	Q-loop/lid; other site
393126009142	ABC transporter signature motif; other site
393126009143	Walker B; other site
393126009144	D-loop; other site
393126009145	H-loop/switch region; other site
393126009146	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393126009147	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393126009148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393126009149	Walker A/P-loop; other site
393126009150	ATP binding site [chemical binding]; other site
393126009151	Q-loop/lid; other site
393126009152	ABC transporter signature motif; other site
393126009153	Walker B; other site
393126009154	D-loop; other site
393126009155	H-loop/switch region; other site
393126009156	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
393126009157	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
393126009158	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
393126009159	Predicted acyl esterases [General function prediction only]; Region: COG2936
393126009160	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
393126009161	DNA topoisomerase III; Provisional; Region: PRK07726
393126009162	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
393126009163	active site
393126009164	putative interdomain interaction site [polypeptide binding]; other site
393126009165	putative metal-binding site [ion binding]; other site
393126009166	putative nucleotide binding site [chemical binding]; other site
393126009167	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
393126009168	domain I; other site
393126009169	DNA binding groove [nucleotide binding]
393126009170	phosphate binding site [ion binding]; other site
393126009171	domain II; other site
393126009172	domain III; other site
393126009173	nucleotide binding site [chemical binding]; other site
393126009174	catalytic site [active]
393126009175	domain IV; other site
393126009176	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
393126009177	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
393126009178	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393126009179	ATP binding site [chemical binding]; other site
393126009180	putative Mg++ binding site [ion binding]; other site
393126009181	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393126009182	nucleotide binding region [chemical binding]; other site
393126009183	ATP-binding site [chemical binding]; other site
393126009184	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
393126009185	HRDC domain; Region: HRDC; pfam00570
393126009186	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
393126009187	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
393126009188	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
393126009189	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
393126009190	active site
393126009191	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
393126009192	putative ADP-ribose binding site [chemical binding]; other site
393126009193	putative active site [active]
393126009194	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393126009195	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126009196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126009197	ABC transporter; Region: ABC_tran_2; pfam12848
393126009198	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393126009199	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393126009200	beta-galactosidase; Region: BGL; TIGR03356
393126009201	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126009202	active site
393126009203	P-loop; other site
393126009204	phosphorylation site [posttranslational modification]
393126009205	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393126009206	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126009207	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126009208	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126009209	nucleotide binding site [chemical binding]; other site
393126009210	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126009211	methionine cluster; other site
393126009212	active site
393126009213	phosphorylation site [posttranslational modification]
393126009214	metal binding site [ion binding]; metal-binding site
393126009215	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126009216	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126009217	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126009218	putative active site [active]
393126009219	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
393126009220	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393126009221	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
393126009222	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393126009223	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393126009224	Walker A/P-loop; other site
393126009225	ATP binding site [chemical binding]; other site
393126009226	Q-loop/lid; other site
393126009227	ABC transporter signature motif; other site
393126009228	Walker B; other site
393126009229	D-loop; other site
393126009230	H-loop/switch region; other site
393126009231	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
393126009232	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
393126009233	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393126009234	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
393126009235	beta-galactosidase; Region: BGL; TIGR03356
393126009236	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393126009237	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126009238	active site turn [active]
393126009239	phosphorylation site [posttranslational modification]
393126009240	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126009241	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393126009242	HPr interaction site; other site
393126009243	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126009244	active site
393126009245	phosphorylation site [posttranslational modification]
393126009246	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393126009247	CAT RNA binding domain; Region: CAT_RBD; smart01061
393126009248	PRD domain; Region: PRD; pfam00874
393126009249	PRD domain; Region: PRD; pfam00874
393126009250	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393126009251	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
393126009252	Walker A/P-loop; other site
393126009253	ATP binding site [chemical binding]; other site
393126009254	Q-loop/lid; other site
393126009255	ABC transporter signature motif; other site
393126009256	Walker B; other site
393126009257	D-loop; other site
393126009258	H-loop/switch region; other site
393126009259	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
393126009260	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
393126009261	bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653
393126009262	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
393126009263	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009264	putative substrate translocation pore; other site
393126009265	GTP-binding protein YchF; Reviewed; Region: PRK09601
393126009266	YchF GTPase; Region: YchF; cd01900
393126009267	G1 box; other site
393126009268	GTP/Mg2+ binding site [chemical binding]; other site
393126009269	Switch I region; other site
393126009270	G2 box; other site
393126009271	Switch II region; other site
393126009272	G3 box; other site
393126009273	G4 box; other site
393126009274	G5 box; other site
393126009275	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
393126009276	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393126009277	methionine cluster; other site
393126009278	active site
393126009279	phosphorylation site [posttranslational modification]
393126009280	metal binding site [ion binding]; metal-binding site
393126009281	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
393126009282	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
393126009283	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
393126009284	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393126009285	active site
393126009286	P-loop; other site
393126009287	phosphorylation site [posttranslational modification]
393126009288	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393126009289	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
393126009290	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393126009291	HTH domain; Region: HTH_11; pfam08279
393126009292	Mga helix-turn-helix domain; Region: Mga; pfam05043
393126009293	PRD domain; Region: PRD; pfam00874
393126009294	PRD domain; Region: PRD; pfam00874
393126009295	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393126009296	active site
393126009297	P-loop; other site
393126009298	phosphorylation site [posttranslational modification]
393126009299	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126009300	active site
393126009301	phosphorylation site [posttranslational modification]
393126009302	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
393126009303	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
393126009304	tetramer interface [polypeptide binding]; other site
393126009305	heme binding pocket [chemical binding]; other site
393126009306	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
393126009307	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393126009308	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393126009309	active site turn [active]
393126009310	phosphorylation site [posttranslational modification]
393126009311	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393126009312	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
393126009313	HPr interaction site; other site
393126009314	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393126009315	active site
393126009316	phosphorylation site [posttranslational modification]
393126009317	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393126009318	CAT RNA binding domain; Region: CAT_RBD; pfam03123
393126009319	PRD domain; Region: PRD; pfam00874
393126009320	PRD domain; Region: PRD; pfam00874
393126009321	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
393126009322	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
393126009323	ParB-like nuclease domain; Region: ParB; smart00470
393126009324	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
393126009325	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
393126009326	P-loop; other site
393126009327	Magnesium ion binding site [ion binding]; other site
393126009328	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
393126009329	Magnesium ion binding site [ion binding]; other site
393126009330	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393126009331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393126009332	non-specific DNA binding site [nucleotide binding]; other site
393126009333	salt bridge; other site
393126009334	sequence-specific DNA binding site [nucleotide binding]; other site
393126009335	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
393126009336	ParB-like nuclease domain; Region: ParBc; pfam02195
393126009337	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393126009338	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393126009339	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393126009340	putative active site [active]
393126009341	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393126009342	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393126009343	nucleotide binding site [chemical binding]; other site
393126009344	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393126009345	active site
393126009346	phosphorylation site [posttranslational modification]
393126009347	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
393126009348	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126009349	motif II; other site
393126009350	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
393126009351	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
393126009352	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
393126009353	active site
393126009354	P-loop; other site
393126009355	phosphorylation site [posttranslational modification]
393126009356	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126009357	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126009358	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393126009359	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
393126009360	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
393126009361	putative active site cavity [active]
393126009362	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
393126009363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393126009364	S-adenosylmethionine binding site [chemical binding]; other site
393126009365	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393126009366	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393126009367	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393126009368	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393126009369	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393126009370	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
393126009371	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
393126009372	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
393126009373	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
393126009374	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
393126009375	trmE is a tRNA modification GTPase; Region: trmE; cd04164
393126009376	G1 box; other site
393126009377	GTP/Mg2+ binding site [chemical binding]; other site
393126009378	Switch I region; other site
393126009379	G2 box; other site
393126009380	Switch II region; other site
393126009381	G3 box; other site
393126009382	G4 box; other site
393126009383	G5 box; other site
393126009384	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
393126009385	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
393126009386	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
393126009387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393126009388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393126009389	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
393126009390	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
393126009391	NADP binding site [chemical binding]; other site
393126009392	homodimer interface [polypeptide binding]; other site
393126009393	active site
393126009394	substrate binding site [chemical binding]; other site
393126009395	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009396	D-galactonate transporter; Region: 2A0114; TIGR00893
393126009397	putative substrate translocation pore; other site
393126009398	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393126009399	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
393126009400	metal binding site [ion binding]; metal-binding site
393126009401	dimer interface [polypeptide binding]; other site
393126009402	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
393126009403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
393126009404	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393126009405	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
393126009406	metal binding site [ion binding]; metal-binding site
393126009407	dimer interface [polypeptide binding]; other site
393126009408	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126009409	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393126009410	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
393126009411	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393126009412	Leucine-rich repeats; other site
393126009413	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126009414	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126009415	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393126009416	Substrate binding site [chemical binding]; other site
393126009417	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126009418	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126009419	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126009420	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393126009421	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393126009422	Uncharacterized conserved protein [Function unknown]; Region: COG4198
393126009423	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
393126009424	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
393126009425	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
393126009426	putative ligand binding site [chemical binding]; other site
393126009427	putative NAD binding site [chemical binding]; other site
393126009428	putative catalytic site [active]
393126009429	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
393126009430	L-serine binding site [chemical binding]; other site
393126009431	ACT domain interface; other site
393126009432	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
393126009433	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393126009434	catalytic residue [active]
393126009435	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009436	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126009437	putative substrate translocation pore; other site
393126009438	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393126009439	MarR family; Region: MarR_2; pfam12802
393126009440	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
393126009441	dimer interface [polypeptide binding]; other site
393126009442	FMN binding site [chemical binding]; other site
393126009443	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393126009444	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393126009445	catalytic residues [active]
393126009446	beta-phosphoglucomutase; Region: bPGM; TIGR01990
393126009447	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393126009448	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393126009449	motif II; other site
393126009450	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
393126009451	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
393126009452	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
393126009453	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
393126009454	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
393126009455	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393126009456	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393126009457	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393126009458	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393126009459	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393126009460	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
393126009461	putative NAD(P) binding site [chemical binding]; other site
393126009462	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393126009463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126009464	dimer interface [polypeptide binding]; other site
393126009465	conserved gate region; other site
393126009466	putative PBP binding loops; other site
393126009467	ABC-ATPase subunit interface; other site
393126009468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393126009469	dimer interface [polypeptide binding]; other site
393126009470	conserved gate region; other site
393126009471	putative PBP binding loops; other site
393126009472	ABC-ATPase subunit interface; other site
393126009473	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393126009474	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393126009475	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
393126009476	sucrose phosphorylase; Provisional; Region: PRK13840
393126009477	active site
393126009478	homodimer interface [polypeptide binding]; other site
393126009479	catalytic site [active]
393126009480	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393126009481	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393126009482	DNA binding site [nucleotide binding]
393126009483	domain linker motif; other site
393126009484	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
393126009485	putative dimerization interface [polypeptide binding]; other site
393126009486	putative ligand binding site [chemical binding]; other site
393126009487	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
393126009488	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393126009489	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393126009490	Coenzyme A binding pocket [chemical binding]; other site
393126009491	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009492	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126009493	putative substrate translocation pore; other site
393126009494	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009495	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
393126009496	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
393126009497	intersubunit interface [polypeptide binding]; other site
393126009498	active site
393126009499	Zn2+ binding site [ion binding]; other site
393126009500	L-rhamnose isomerase; Provisional; Region: PRK01076
393126009501	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
393126009502	N- and C-terminal domain interface [polypeptide binding]; other site
393126009503	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
393126009504	active site
393126009505	putative catalytic site [active]
393126009506	metal binding site [ion binding]; metal-binding site
393126009507	ATP binding site [chemical binding]; other site
393126009508	carbohydrate binding site [chemical binding]; other site
393126009509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393126009510	putative substrate translocation pore; other site
393126009511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393126009512	Cupin domain; Region: Cupin_2; pfam07883
393126009513	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393126009514	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
393126009515	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
393126009516	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
393126009517	G-X-X-G motif; other site
393126009518	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
393126009519	RxxxH motif; other site
393126009520	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
393126009521	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
393126009522	ribonuclease P; Reviewed; Region: rnpA; PRK00499
393126009523	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399