-- dump date 20140619_132523 -- class Genbank::misc_feature -- table misc_feature_note -- id note 393127000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 393127000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 393127000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127000004 Walker A motif; other site 393127000005 ATP binding site [chemical binding]; other site 393127000006 Walker B motif; other site 393127000007 arginine finger; other site 393127000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 393127000009 DnaA box-binding interface [nucleotide binding]; other site 393127000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 393127000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 393127000012 putative DNA binding surface [nucleotide binding]; other site 393127000013 dimer interface [polypeptide binding]; other site 393127000014 beta-clamp/clamp loader binding surface; other site 393127000015 beta-clamp/translesion DNA polymerase binding surface; other site 393127000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393127000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 393127000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 393127000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 393127000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 393127000021 Walker A/P-loop; other site 393127000022 ATP binding site [chemical binding]; other site 393127000023 Q-loop/lid; other site 393127000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127000025 ABC transporter signature motif; other site 393127000026 Walker B; other site 393127000027 D-loop; other site 393127000028 H-loop/switch region; other site 393127000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 393127000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127000031 Mg2+ binding site [ion binding]; other site 393127000032 G-X-G motif; other site 393127000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393127000034 anchoring element; other site 393127000035 dimer interface [polypeptide binding]; other site 393127000036 ATP binding site [chemical binding]; other site 393127000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 393127000038 active site 393127000039 putative metal-binding site [ion binding]; other site 393127000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393127000041 DNA gyrase subunit A; Validated; Region: PRK05560 393127000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393127000043 CAP-like domain; other site 393127000044 active site 393127000045 primary dimer interface [polypeptide binding]; other site 393127000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127000051 cardiolipin synthetase; Reviewed; Region: PRK12452 393127000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 393127000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 393127000054 putative active site [active] 393127000055 catalytic site [active] 393127000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 393127000057 putative active site [active] 393127000058 catalytic site [active] 393127000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393127000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127000061 Coenzyme A binding pocket [chemical binding]; other site 393127000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 393127000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393127000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393127000065 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 393127000066 diphosphomevalonate decarboxylase; Region: PLN02407 393127000067 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 393127000068 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393127000069 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 393127000070 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 393127000071 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 393127000072 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 393127000073 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 393127000074 D-pathway; other site 393127000075 Putative ubiquinol binding site [chemical binding]; other site 393127000076 Low-spin heme (heme b) binding site [chemical binding]; other site 393127000077 Putative water exit pathway; other site 393127000078 Binuclear center (heme o3/CuB) [ion binding]; other site 393127000079 K-pathway; other site 393127000080 Putative proton exit pathway; other site 393127000081 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 393127000082 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 393127000083 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 393127000084 putative active site [active] 393127000085 putative metal binding site [ion binding]; other site 393127000086 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 393127000087 beta-galactosidase; Region: BGL; TIGR03356 393127000088 Bacterial SH3 domain; Region: SH3_3; pfam08239 393127000089 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 393127000090 putative active site [active] 393127000091 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127000092 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127000093 DNA-binding site [nucleotide binding]; DNA binding site 393127000094 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393127000095 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127000096 active site 393127000097 active pocket/dimerization site; other site 393127000098 phosphorylation site [posttranslational modification] 393127000099 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393127000100 active site 393127000101 phosphorylation site [posttranslational modification] 393127000102 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 393127000103 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 393127000104 hypothetical protein; Provisional; Region: PRK02947 393127000105 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127000106 putative active site [active] 393127000107 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 393127000108 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 393127000109 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127000110 active site turn [active] 393127000111 phosphorylation site [posttranslational modification] 393127000112 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127000113 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393127000114 HPr interaction site; other site 393127000115 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127000116 active site 393127000117 phosphorylation site [posttranslational modification] 393127000118 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 393127000119 putative dimer interface [polypeptide binding]; other site 393127000120 catalytic triad [active] 393127000121 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393127000122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127000123 Walker A/P-loop; other site 393127000124 ATP binding site [chemical binding]; other site 393127000125 Q-loop/lid; other site 393127000126 ABC transporter signature motif; other site 393127000127 Walker B; other site 393127000128 D-loop; other site 393127000129 H-loop/switch region; other site 393127000130 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 393127000131 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 393127000132 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127000133 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000134 active site 393127000135 motif I; other site 393127000136 motif II; other site 393127000137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127000139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127000140 DNA binding site [nucleotide binding] 393127000141 domain linker motif; other site 393127000142 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 393127000143 dimerization interface [polypeptide binding]; other site 393127000144 putative ligand binding site [chemical binding]; other site 393127000145 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127000146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127000147 nucleotide binding site [chemical binding]; other site 393127000148 Butyrate kinase [Energy production and conversion]; Region: COG3426 393127000149 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 393127000150 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127000151 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127000152 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393127000153 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393127000154 dimer interface [polypeptide binding]; other site 393127000155 active site 393127000156 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393127000157 dimer interface [polypeptide binding]; other site 393127000158 active site 393127000159 putrescine carbamoyltransferase; Provisional; Region: PRK02255 393127000160 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393127000161 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393127000162 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 393127000163 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 393127000164 agmatine deiminase; Provisional; Region: PRK13551 393127000165 agmatine deiminase; Region: agmatine_aguA; TIGR03380 393127000166 carbamate kinase; Reviewed; Region: PRK12686 393127000167 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 393127000168 putative substrate binding site [chemical binding]; other site 393127000169 nucleotide binding site [chemical binding]; other site 393127000170 nucleotide binding site [chemical binding]; other site 393127000171 homodimer interface [polypeptide binding]; other site 393127000172 agmatine deiminase; Provisional; Region: PRK13551 393127000173 agmatine deiminase; Region: agmatine_aguA; TIGR03380 393127000174 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127000175 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127000176 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127000177 putative active site [active] 393127000178 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 393127000179 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393127000180 arginine deiminase; Provisional; Region: PRK01388 393127000181 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 393127000182 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 393127000183 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 393127000184 dimer interface [polypeptide binding]; other site 393127000185 ssDNA binding site [nucleotide binding]; other site 393127000186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127000187 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 393127000188 Predicted membrane protein [Function unknown]; Region: COG3212 393127000189 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393127000190 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393127000191 putative accessory gene regulator protein; Provisional; Region: PRK01100 393127000192 Staphylococcal AgrD protein; Region: AgrD; cl05477 393127000193 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 393127000194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127000195 ATP binding site [chemical binding]; other site 393127000196 Mg2+ binding site [ion binding]; other site 393127000197 G-X-G motif; other site 393127000198 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 393127000199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127000200 active site 393127000201 phosphorylation site [posttranslational modification] 393127000202 intermolecular recognition site; other site 393127000203 LytTr DNA-binding domain; Region: LytTR; pfam04397 393127000204 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 393127000205 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 393127000206 DHH family; Region: DHH; pfam01368 393127000207 DHHA1 domain; Region: DHHA1; pfam02272 393127000208 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 393127000209 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 393127000210 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 393127000211 replicative DNA helicase; Provisional; Region: PRK05748 393127000212 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 393127000213 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 393127000214 Walker A motif; other site 393127000215 ATP binding site [chemical binding]; other site 393127000216 Walker B motif; other site 393127000217 DNA binding loops [nucleotide binding] 393127000218 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 393127000219 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 393127000220 GDP-binding site [chemical binding]; other site 393127000221 ACT binding site; other site 393127000222 IMP binding site; other site 393127000223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 393127000224 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393127000225 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 393127000226 Predicted membrane protein [Function unknown]; Region: COG1511 393127000227 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 393127000228 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 393127000229 Uncharacterized small protein [Function unknown]; Region: COG5417 393127000230 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 393127000231 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 393127000232 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 393127000233 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 393127000234 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393127000235 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393127000236 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393127000237 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2; Region: Mfa2; pfam08842 393127000238 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 393127000239 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 393127000240 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 393127000241 tetramer interface [polypeptide binding]; other site 393127000242 active site 393127000243 Mg2+/Mn2+ binding site [ion binding]; other site 393127000244 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 393127000245 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 393127000246 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393127000247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393127000248 DNA binding site [nucleotide binding] 393127000249 active site 393127000250 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 393127000251 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 393127000252 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 393127000253 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 393127000254 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 393127000255 putative ligand binding site [chemical binding]; other site 393127000256 putative NAD binding site [chemical binding]; other site 393127000257 catalytic site [active] 393127000258 LXG domain of WXG superfamily; Region: LXG; pfam04740 393127000259 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127000260 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127000261 DNA binding residues [nucleotide binding] 393127000262 putative dimer interface [polypeptide binding]; other site 393127000263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127000264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127000265 active site 393127000266 catalytic tetrad [active] 393127000267 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000268 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127000269 ATP synthase subunit C; Region: ATP-synt_C; cl00466 393127000270 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 393127000271 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 393127000272 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393127000273 Walker A motif; other site 393127000274 ATP binding site [chemical binding]; other site 393127000275 Walker B motif; other site 393127000276 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393127000277 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 393127000278 core domain interface [polypeptide binding]; other site 393127000279 delta subunit interface [polypeptide binding]; other site 393127000280 epsilon subunit interface [polypeptide binding]; other site 393127000281 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 393127000282 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393127000283 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 393127000284 alpha subunit interaction interface [polypeptide binding]; other site 393127000285 Walker A motif; other site 393127000286 ATP binding site [chemical binding]; other site 393127000287 Walker B motif; other site 393127000288 inhibitor binding site; inhibition site 393127000289 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393127000290 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 393127000291 gamma subunit interface [polypeptide binding]; other site 393127000292 epsilon subunit interface [polypeptide binding]; other site 393127000293 LBP interface [polypeptide binding]; other site 393127000294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000295 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 393127000296 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127000297 active pocket/dimerization site; other site 393127000298 active site 393127000299 phosphorylation site [posttranslational modification] 393127000300 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393127000301 active site 393127000302 phosphorylation site [posttranslational modification] 393127000303 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 393127000304 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 393127000305 Domain of unknown function (DUF956); Region: DUF956; pfam06115 393127000306 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 393127000307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127000308 dimerization interface [polypeptide binding]; other site 393127000309 putative DNA binding site [nucleotide binding]; other site 393127000310 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393127000311 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 393127000312 dimer interface [polypeptide binding]; other site 393127000313 FMN binding site [chemical binding]; other site 393127000314 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 393127000315 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 393127000316 active site 393127000317 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 393127000318 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 393127000319 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393127000320 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393127000321 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127000322 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127000323 nucleotide binding site [chemical binding]; other site 393127000324 butyrate kinase; Region: butyr_kinase; TIGR02707 393127000325 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127000326 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127000327 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393127000328 Walker A/P-loop; other site 393127000329 ATP binding site [chemical binding]; other site 393127000330 Q-loop/lid; other site 393127000331 ABC transporter signature motif; other site 393127000332 Walker B; other site 393127000333 D-loop; other site 393127000334 H-loop/switch region; other site 393127000335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127000336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127000337 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393127000338 Walker A/P-loop; other site 393127000339 ATP binding site [chemical binding]; other site 393127000340 Q-loop/lid; other site 393127000341 ABC transporter signature motif; other site 393127000342 Walker B; other site 393127000343 D-loop; other site 393127000344 H-loop/switch region; other site 393127000345 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 393127000346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127000347 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127000348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127000349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 393127000350 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393127000351 substrate binding pocket [chemical binding]; other site 393127000352 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393127000353 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000354 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393127000355 ligand binding site [chemical binding]; other site 393127000356 flexible hinge region; other site 393127000357 Domain of unknown function (DUF955); Region: DUF955; pfam06114 393127000358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127000359 non-specific DNA binding site [nucleotide binding]; other site 393127000360 salt bridge; other site 393127000361 sequence-specific DNA binding site [nucleotide binding]; other site 393127000362 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 393127000363 Predicted secreted protein [Function unknown]; Region: COG5437 393127000364 Phage-related protein [Function unknown]; Region: COG5412 393127000365 Phage tail protein; Region: Sipho_tail; pfam05709 393127000366 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 393127000367 Predicted membrane protein [Function unknown]; Region: COG1511 393127000368 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 393127000369 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 393127000370 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 393127000371 active site 393127000372 metal binding site [ion binding]; metal-binding site 393127000373 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 393127000374 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 393127000375 putative active site [active] 393127000376 putative metal binding site [ion binding]; other site 393127000377 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 393127000378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393127000379 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 393127000380 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 393127000381 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 393127000382 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 393127000383 active site 393127000384 Uncharacterized conserved protein [Function unknown]; Region: COG3592 393127000385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127000386 Coenzyme A binding pocket [chemical binding]; other site 393127000387 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 393127000388 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 393127000389 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393127000390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000391 dimer interface [polypeptide binding]; other site 393127000392 conserved gate region; other site 393127000393 putative PBP binding loops; other site 393127000394 ABC-ATPase subunit interface; other site 393127000395 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393127000396 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 393127000397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000398 dimer interface [polypeptide binding]; other site 393127000399 conserved gate region; other site 393127000400 putative PBP binding loops; other site 393127000401 ABC-ATPase subunit interface; other site 393127000402 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 393127000403 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 393127000404 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393127000405 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393127000406 peptide binding site [polypeptide binding]; other site 393127000407 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393127000408 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 393127000409 metal binding site [ion binding]; metal-binding site 393127000410 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 393127000411 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393127000412 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393127000413 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127000414 ABC-ATPase subunit interface; other site 393127000415 dimer interface [polypeptide binding]; other site 393127000416 putative PBP binding regions; other site 393127000417 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000418 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127000419 ligand binding site [chemical binding]; other site 393127000420 flexible hinge region; other site 393127000421 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 393127000422 DEAD_2; Region: DEAD_2; pfam06733 393127000423 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 393127000424 sugar phosphate phosphatase; Provisional; Region: PRK10513 393127000425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000426 active site 393127000427 motif I; other site 393127000428 motif II; other site 393127000429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000430 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393127000431 Collagen binding domain; Region: Collagen_bind; pfam05737 393127000432 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000433 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000434 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000435 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000436 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393127000437 Collagen binding domain; Region: Collagen_bind; pfam05737 393127000438 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000439 Cna protein B-type domain; Region: Cna_B; pfam05738 393127000440 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127000441 DNA polymerase III subunit delta'; Validated; Region: PRK08058 393127000442 DNA polymerase III subunit delta'; Validated; Region: PRK08485 393127000443 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 393127000444 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 393127000445 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 393127000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127000447 S-adenosylmethionine binding site [chemical binding]; other site 393127000448 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 393127000449 GIY-YIG motif/motif A; other site 393127000450 putative active site [active] 393127000451 putative metal binding site [ion binding]; other site 393127000452 Predicted methyltransferases [General function prediction only]; Region: COG0313 393127000453 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 393127000454 putative SAM binding site [chemical binding]; other site 393127000455 putative homodimer interface [polypeptide binding]; other site 393127000456 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 393127000457 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 393127000458 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393127000459 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393127000460 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393127000461 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 393127000462 Leucine rich repeat; Region: LRR_8; pfam13855 393127000463 LRR adjacent; Region: LRR_adjacent; pfam08191 393127000464 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127000465 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127000466 HTH-like domain; Region: HTH_21; pfam13276 393127000467 Integrase core domain; Region: rve; pfam00665 393127000468 Integrase core domain; Region: rve_3; cl15866 393127000469 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393127000470 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393127000471 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127000472 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393127000473 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 393127000474 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 393127000475 active site 393127000476 HIGH motif; other site 393127000477 KMSKS motif; other site 393127000478 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 393127000479 tRNA binding surface [nucleotide binding]; other site 393127000480 anticodon binding site; other site 393127000481 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 393127000482 dimer interface [polypeptide binding]; other site 393127000483 putative tRNA-binding site [nucleotide binding]; other site 393127000484 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 393127000485 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127000486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127000487 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393127000488 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393127000489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000490 dimer interface [polypeptide binding]; other site 393127000491 conserved gate region; other site 393127000492 putative PBP binding loops; other site 393127000493 ABC-ATPase subunit interface; other site 393127000494 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127000495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000496 dimer interface [polypeptide binding]; other site 393127000497 conserved gate region; other site 393127000498 putative PBP binding loops; other site 393127000499 ABC-ATPase subunit interface; other site 393127000500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393127000501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127000502 alpha-glucosidase; Provisional; Region: PRK10426 393127000503 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393127000504 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 393127000505 active site 393127000506 catalytic site [active] 393127000507 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393127000508 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393127000509 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 393127000510 trimer interface [polypeptide binding]; other site 393127000511 active site 393127000512 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 393127000513 catalytic site [active] 393127000514 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393127000515 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393127000516 Ca binding site [ion binding]; other site 393127000517 active site 393127000518 catalytic site [active] 393127000519 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 393127000520 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 393127000521 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 393127000522 active site 393127000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 393127000524 Domain of unknown function (DUF348); Region: DUF348; pfam03990 393127000525 Domain of unknown function (DUF348); Region: DUF348; pfam03990 393127000526 G5 domain; Region: G5; pfam07501 393127000527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 393127000528 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 393127000529 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 393127000530 putative active site [active] 393127000531 putative metal binding site [ion binding]; other site 393127000532 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 393127000533 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 393127000534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127000535 S-adenosylmethionine binding site [chemical binding]; other site 393127000536 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 393127000537 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 393127000538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393127000539 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 393127000540 putative active site [active] 393127000541 YdjC motif; other site 393127000542 Mg binding site [ion binding]; other site 393127000543 putative homodimer interface [polypeptide binding]; other site 393127000544 pur operon repressor; Provisional; Region: PRK09213 393127000545 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 393127000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127000547 active site 393127000548 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 393127000549 HlyD family secretion protein; Region: HlyD_3; pfam13437 393127000550 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127000551 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127000552 Walker A/P-loop; other site 393127000553 ATP binding site [chemical binding]; other site 393127000554 Q-loop/lid; other site 393127000555 ABC transporter signature motif; other site 393127000556 Walker B; other site 393127000557 D-loop; other site 393127000558 H-loop/switch region; other site 393127000559 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127000560 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127000561 FtsX-like permease family; Region: FtsX; pfam02687 393127000562 regulatory protein SpoVG; Reviewed; Region: PRK13259 393127000563 regulatory protein SpoVG; Reviewed; Region: PRK13259 393127000564 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 393127000565 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 393127000566 Substrate binding site; other site 393127000567 Mg++ binding site; other site 393127000568 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 393127000569 active site 393127000570 substrate binding site [chemical binding]; other site 393127000571 CoA binding site [chemical binding]; other site 393127000572 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 393127000573 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 393127000574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127000575 active site 393127000576 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000577 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127000578 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127000579 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 393127000580 active site 393127000581 catalytic site [active] 393127000582 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 393127000583 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 393127000584 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 393127000585 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393127000586 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 393127000587 active site 393127000588 Zn binding site [ion binding]; other site 393127000589 ActA Protein; Region: ActA; pfam05058 393127000590 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 393127000591 Zn binding site [ion binding]; other site 393127000592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 393127000593 hypothetical protein; Provisional; Region: PRK01119 393127000594 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 393127000595 A new structural DNA glycosylase; Region: AlkD_like; cd06561 393127000596 active site 393127000597 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 393127000598 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393127000599 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127000600 NAD binding site [chemical binding]; other site 393127000601 dimer interface [polypeptide binding]; other site 393127000602 substrate binding site [chemical binding]; other site 393127000603 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 393127000604 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 393127000605 5S rRNA interface [nucleotide binding]; other site 393127000606 CTC domain interface [polypeptide binding]; other site 393127000607 L16 interface [polypeptide binding]; other site 393127000608 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127000609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127000610 Coenzyme A binding pocket [chemical binding]; other site 393127000611 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 393127000612 putative active site [active] 393127000613 catalytic residue [active] 393127000614 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 393127000615 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 393127000616 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127000617 ATP binding site [chemical binding]; other site 393127000618 putative Mg++ binding site [ion binding]; other site 393127000619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127000620 nucleotide binding region [chemical binding]; other site 393127000621 ATP-binding site [chemical binding]; other site 393127000622 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 393127000623 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393127000624 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393127000625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127000626 RNA binding surface [nucleotide binding]; other site 393127000627 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 393127000628 Septum formation initiator; Region: DivIC; pfam04977 393127000629 hypothetical protein; Provisional; Region: PRK08582 393127000630 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393127000631 RNA binding site [nucleotide binding]; other site 393127000632 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 393127000633 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 393127000634 Ligand Binding Site [chemical binding]; other site 393127000635 TilS substrate C-terminal domain; Region: TilS_C; smart00977 393127000636 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 393127000637 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127000638 active site 393127000639 FtsH Extracellular; Region: FtsH_ext; pfam06480 393127000640 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 393127000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127000642 Walker A motif; other site 393127000643 ATP binding site [chemical binding]; other site 393127000644 Walker B motif; other site 393127000645 arginine finger; other site 393127000646 Peptidase family M41; Region: Peptidase_M41; pfam01434 393127000647 pantothenate kinase; Reviewed; Region: PRK13318 393127000648 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 393127000649 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 393127000650 dimerization interface [polypeptide binding]; other site 393127000651 domain crossover interface; other site 393127000652 redox-dependent activation switch; other site 393127000653 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 393127000654 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 393127000655 dimer interface [polypeptide binding]; other site 393127000656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127000657 catalytic residue [active] 393127000658 dihydropteroate synthase; Region: DHPS; TIGR01496 393127000659 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 393127000660 substrate binding pocket [chemical binding]; other site 393127000661 dimer interface [polypeptide binding]; other site 393127000662 inhibitor binding site; inhibition site 393127000663 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 393127000664 homooctamer interface [polypeptide binding]; other site 393127000665 active site 393127000666 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 393127000667 catalytic center binding site [active] 393127000668 ATP binding site [chemical binding]; other site 393127000669 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 393127000670 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 393127000671 FMN binding site [chemical binding]; other site 393127000672 active site 393127000673 catalytic residues [active] 393127000674 substrate binding site [chemical binding]; other site 393127000675 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 393127000676 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 393127000677 dimer interface [polypeptide binding]; other site 393127000678 putative anticodon binding site; other site 393127000679 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 393127000680 motif 1; other site 393127000681 active site 393127000682 motif 2; other site 393127000683 motif 3; other site 393127000684 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 393127000685 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 393127000686 UvrB/uvrC motif; Region: UVR; pfam02151 393127000687 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 393127000688 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 393127000689 ADP binding site [chemical binding]; other site 393127000690 phosphagen binding site; other site 393127000691 substrate specificity loop; other site 393127000692 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 393127000693 Clp amino terminal domain; Region: Clp_N; pfam02861 393127000694 Clp amino terminal domain; Region: Clp_N; pfam02861 393127000695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127000696 Walker A motif; other site 393127000697 ATP binding site [chemical binding]; other site 393127000698 Walker B motif; other site 393127000699 arginine finger; other site 393127000700 UvrB/uvrC motif; Region: UVR; pfam02151 393127000701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127000702 Walker A motif; other site 393127000703 ATP binding site [chemical binding]; other site 393127000704 Walker B motif; other site 393127000705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393127000706 DNA repair protein RadA; Provisional; Region: PRK11823 393127000707 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 393127000708 Walker A motif/ATP binding site; other site 393127000709 ATP binding site [chemical binding]; other site 393127000710 Walker B motif; other site 393127000711 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 393127000712 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 393127000713 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 393127000714 putative active site [active] 393127000715 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 393127000716 substrate binding site; other site 393127000717 dimer interface; other site 393127000718 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 393127000719 homotrimer interaction site [polypeptide binding]; other site 393127000720 zinc binding site [ion binding]; other site 393127000721 CDP-binding sites; other site 393127000722 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 393127000723 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393127000724 HIGH motif; other site 393127000725 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 393127000726 active site 393127000727 KMSKS motif; other site 393127000728 serine O-acetyltransferase; Region: cysE; TIGR01172 393127000729 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 393127000730 trimer interface [polypeptide binding]; other site 393127000731 active site 393127000732 substrate binding site [chemical binding]; other site 393127000733 CoA binding site [chemical binding]; other site 393127000734 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 393127000735 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393127000736 active site 393127000737 HIGH motif; other site 393127000738 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 393127000739 KMSKS motif; other site 393127000740 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 393127000741 tRNA binding surface [nucleotide binding]; other site 393127000742 anticodon binding site; other site 393127000743 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 393127000744 active site 393127000745 metal binding site [ion binding]; metal-binding site 393127000746 dimerization interface [polypeptide binding]; other site 393127000747 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 393127000748 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 393127000749 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393127000750 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 393127000751 RNA polymerase factor sigma-70; Validated; Region: PRK08295 393127000752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393127000753 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 393127000754 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 393127000755 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 393127000756 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 393127000757 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 393127000758 putative homodimer interface [polypeptide binding]; other site 393127000759 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 393127000760 heterodimer interface [polypeptide binding]; other site 393127000761 homodimer interface [polypeptide binding]; other site 393127000762 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 393127000763 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 393127000764 23S rRNA interface [nucleotide binding]; other site 393127000765 L7/L12 interface [polypeptide binding]; other site 393127000766 putative thiostrepton binding site; other site 393127000767 L25 interface [polypeptide binding]; other site 393127000768 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 393127000769 mRNA/rRNA interface [nucleotide binding]; other site 393127000770 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 393127000771 23S rRNA interface [nucleotide binding]; other site 393127000772 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 393127000773 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 393127000774 core dimer interface [polypeptide binding]; other site 393127000775 peripheral dimer interface [polypeptide binding]; other site 393127000776 L10 interface [polypeptide binding]; other site 393127000777 L11 interface [polypeptide binding]; other site 393127000778 putative EF-Tu interaction site [polypeptide binding]; other site 393127000779 putative EF-G interaction site [polypeptide binding]; other site 393127000780 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393127000781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127000782 S-adenosylmethionine binding site [chemical binding]; other site 393127000783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 393127000784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127000785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127000786 DNA binding site [nucleotide binding] 393127000787 domain linker motif; other site 393127000788 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 393127000789 putative dimerization interface [polypeptide binding]; other site 393127000790 putative ligand binding site [chemical binding]; other site 393127000791 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 393127000792 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127000793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393127000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000795 dimer interface [polypeptide binding]; other site 393127000796 conserved gate region; other site 393127000797 putative PBP binding loops; other site 393127000798 ABC-ATPase subunit interface; other site 393127000799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127000800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000801 dimer interface [polypeptide binding]; other site 393127000802 conserved gate region; other site 393127000803 putative PBP binding loops; other site 393127000804 ABC-ATPase subunit interface; other site 393127000805 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393127000806 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393127000807 Ca binding site [ion binding]; other site 393127000808 active site 393127000809 catalytic site [active] 393127000810 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 393127000811 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 393127000812 active site 393127000813 homodimer interface [polypeptide binding]; other site 393127000814 catalytic site [active] 393127000815 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 393127000816 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393127000817 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393127000818 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 393127000819 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 393127000820 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 393127000821 RPB10 interaction site [polypeptide binding]; other site 393127000822 RPB1 interaction site [polypeptide binding]; other site 393127000823 RPB11 interaction site [polypeptide binding]; other site 393127000824 RPB3 interaction site [polypeptide binding]; other site 393127000825 RPB12 interaction site [polypeptide binding]; other site 393127000826 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 393127000827 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 393127000828 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 393127000829 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 393127000830 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 393127000831 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 393127000832 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 393127000833 G-loop; other site 393127000834 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 393127000835 DNA binding site [nucleotide binding] 393127000836 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 393127000837 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 393127000838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000839 active site 393127000840 motif I; other site 393127000841 motif II; other site 393127000842 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127000843 beta-galactosidase; Region: BGL; TIGR03356 393127000844 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127000845 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127000846 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000847 Substrate binding site [chemical binding]; other site 393127000848 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000849 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000850 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000851 LRR adjacent; Region: LRR_adjacent; pfam08191 393127000852 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000853 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000854 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127000855 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127000856 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127000857 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000858 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000859 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000860 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000861 LRR adjacent; Region: LRR_adjacent; pfam08191 393127000862 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000863 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000864 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127000865 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127000866 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000867 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000868 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000870 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000871 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000872 LRR adjacent; Region: LRR_adjacent; pfam08191 393127000873 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000874 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000875 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127000876 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000877 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000878 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127000881 LRR adjacent; Region: LRR_adjacent; pfam08191 393127000882 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127000883 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127000884 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 393127000885 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 393127000886 metal binding site [ion binding]; metal-binding site 393127000887 dimer interface [polypeptide binding]; other site 393127000888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127000889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127000890 putative Zn2+ binding site [ion binding]; other site 393127000891 putative DNA binding site [nucleotide binding]; other site 393127000892 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393127000893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127000894 Zn binding site [ion binding]; other site 393127000895 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393127000896 Zn binding site [ion binding]; other site 393127000897 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127000898 catalytic core [active] 393127000899 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393127000900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000901 dimer interface [polypeptide binding]; other site 393127000902 conserved gate region; other site 393127000903 putative PBP binding loops; other site 393127000904 ABC-ATPase subunit interface; other site 393127000905 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393127000906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000907 dimer interface [polypeptide binding]; other site 393127000908 conserved gate region; other site 393127000909 ABC-ATPase subunit interface; other site 393127000910 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 393127000911 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127000912 beta-galactosidase; Region: BGL; TIGR03356 393127000913 sugar phosphate phosphatase; Provisional; Region: PRK10513 393127000914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000915 active site 393127000916 motif I; other site 393127000917 motif II; other site 393127000918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127000920 Coenzyme A binding pocket [chemical binding]; other site 393127000921 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000922 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127000923 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 393127000924 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393127000925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000926 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 393127000927 active site 393127000928 motif I; other site 393127000929 motif II; other site 393127000930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127000931 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127000932 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127000933 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393127000934 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 393127000935 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 393127000936 Walker A/P-loop; other site 393127000937 ATP binding site [chemical binding]; other site 393127000938 Q-loop/lid; other site 393127000939 ABC transporter signature motif; other site 393127000940 Walker B; other site 393127000941 D-loop; other site 393127000942 H-loop/switch region; other site 393127000943 TOBE domain; Region: TOBE; pfam03459 393127000944 ATP cone domain; Region: ATP-cone; pfam03477 393127000945 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 393127000946 Class III ribonucleotide reductase; Region: RNR_III; cd01675 393127000947 effector binding site; other site 393127000948 active site 393127000949 Zn binding site [ion binding]; other site 393127000950 glycine loop; other site 393127000951 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 393127000952 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 393127000953 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127000954 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127000955 ligand binding site [chemical binding]; other site 393127000956 flexible hinge region; other site 393127000957 Predicted amidohydrolase [General function prediction only]; Region: COG0388 393127000958 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 393127000959 putative active site [active] 393127000960 catalytic triad [active] 393127000961 putative dimer interface [polypeptide binding]; other site 393127000962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127000963 dimer interface [polypeptide binding]; other site 393127000964 conserved gate region; other site 393127000965 ABC-ATPase subunit interface; other site 393127000966 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 393127000967 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 393127000968 Walker A/P-loop; other site 393127000969 ATP binding site [chemical binding]; other site 393127000970 Q-loop/lid; other site 393127000971 ABC transporter signature motif; other site 393127000972 Walker B; other site 393127000973 D-loop; other site 393127000974 H-loop/switch region; other site 393127000975 NIL domain; Region: NIL; pfam09383 393127000976 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 393127000977 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 393127000978 transaminase; Reviewed; Region: PRK08068 393127000979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127000980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127000981 homodimer interface [polypeptide binding]; other site 393127000982 catalytic residue [active] 393127000983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127000984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127000985 active site 393127000986 phosphorylation site [posttranslational modification] 393127000987 intermolecular recognition site; other site 393127000988 dimerization interface [polypeptide binding]; other site 393127000989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127000990 DNA binding site [nucleotide binding] 393127000991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 393127000992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127000993 dimerization interface [polypeptide binding]; other site 393127000994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393127000995 putative active site [active] 393127000996 heme pocket [chemical binding]; other site 393127000997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127000998 dimer interface [polypeptide binding]; other site 393127000999 phosphorylation site [posttranslational modification] 393127001000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127001001 ATP binding site [chemical binding]; other site 393127001002 Mg2+ binding site [ion binding]; other site 393127001003 G-X-G motif; other site 393127001004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 393127001005 YycH protein; Region: YycH; pfam07435 393127001006 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 393127001007 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 393127001008 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 393127001009 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 393127001010 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 393127001011 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 393127001012 protein binding site [polypeptide binding]; other site 393127001013 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 393127001014 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127001015 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127001016 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393127001017 dimerization interface [polypeptide binding]; other site 393127001018 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 393127001019 dimer interface [polypeptide binding]; other site 393127001020 FMN binding site [chemical binding]; other site 393127001021 NADPH bind site [chemical binding]; other site 393127001022 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127001023 HTH domain; Region: HTH_11; pfam08279 393127001024 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127001025 PRD domain; Region: PRD; pfam00874 393127001026 PRD domain; Region: PRD; pfam00874 393127001027 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127001028 active site 393127001029 P-loop; other site 393127001030 phosphorylation site [posttranslational modification] 393127001031 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001032 active site 393127001033 phosphorylation site [posttranslational modification] 393127001034 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127001035 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127001036 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127001037 active site 393127001038 P-loop; other site 393127001039 phosphorylation site [posttranslational modification] 393127001040 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127001041 beta-galactosidase; Region: BGL; TIGR03356 393127001042 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127001043 methionine cluster; other site 393127001044 active site 393127001045 phosphorylation site [posttranslational modification] 393127001046 metal binding site [ion binding]; metal-binding site 393127001047 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 393127001048 Mrr N-terminal domain; Region: Mrr_N; pfam14338 393127001049 Restriction endonuclease; Region: Mrr_cat; pfam04471 393127001050 Part of AAA domain; Region: AAA_19; pfam13245 393127001051 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 393127001052 AAA domain; Region: AAA_12; pfam13087 393127001053 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 393127001054 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 393127001055 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 393127001056 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 393127001057 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127001058 catalytic residue [active] 393127001059 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 393127001060 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 393127001061 putative active site [active] 393127001062 YdjC motif; other site 393127001063 Mg binding site [ion binding]; other site 393127001064 putative homodimer interface [polypeptide binding]; other site 393127001065 Putative transcription activator [Transcription]; Region: TenA; COG0819 393127001066 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 393127001067 substrate binding site [chemical binding]; other site 393127001068 multimerization interface [polypeptide binding]; other site 393127001069 ATP binding site [chemical binding]; other site 393127001070 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 393127001071 dimer interface [polypeptide binding]; other site 393127001072 substrate binding site [chemical binding]; other site 393127001073 ATP binding site [chemical binding]; other site 393127001074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 393127001075 thiamine phosphate binding site [chemical binding]; other site 393127001076 active site 393127001077 pyrophosphate binding site [ion binding]; other site 393127001078 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127001079 beta-galactosidase; Region: BGL; TIGR03356 393127001080 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127001081 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 393127001082 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 393127001083 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 393127001084 putative catalytic site [active] 393127001085 putative metal binding site [ion binding]; other site 393127001086 putative phosphate binding site [ion binding]; other site 393127001087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127001088 non-specific DNA binding site [nucleotide binding]; other site 393127001089 salt bridge; other site 393127001090 sequence-specific DNA binding site [nucleotide binding]; other site 393127001091 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393127001092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127001093 non-specific DNA binding site [nucleotide binding]; other site 393127001094 salt bridge; other site 393127001095 sequence-specific DNA binding site [nucleotide binding]; other site 393127001096 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393127001097 Leucine rich repeat; Region: LRR_8; pfam13855 393127001098 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001099 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001100 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001101 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001102 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001103 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001104 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001105 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001106 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001107 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001108 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001109 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001110 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001111 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001112 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001113 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 393127001114 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127001115 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127001116 Leucine-rich repeats; other site 393127001117 Substrate binding site [chemical binding]; other site 393127001118 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001119 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001120 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001121 Leucine rich repeat; Region: LRR_8; pfam13855 393127001122 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127001123 Leucine-rich repeats; other site 393127001124 Substrate binding site [chemical binding]; other site 393127001125 Leucine rich repeat; Region: LRR_8; pfam13855 393127001126 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001127 Leucine rich repeat; Region: LRR_8; pfam13855 393127001128 Leucine rich repeat; Region: LRR_8; pfam13855 393127001129 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001130 LRR adjacent; Region: LRR_adjacent; pfam08191 393127001131 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001132 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001133 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001134 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 393127001135 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 393127001136 LXG domain of WXG superfamily; Region: LXG; pfam04740 393127001137 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 393127001138 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 393127001139 Enterocin A Immunity; Region: EntA_Immun; pfam08951 393127001140 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393127001141 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393127001142 TPP-binding site [chemical binding]; other site 393127001143 dimer interface [polypeptide binding]; other site 393127001144 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393127001145 PYR/PP interface [polypeptide binding]; other site 393127001146 dimer interface [polypeptide binding]; other site 393127001147 TPP binding site [chemical binding]; other site 393127001148 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127001149 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 393127001150 active site 393127001151 intersubunit interactions; other site 393127001152 catalytic residue [active] 393127001153 short chain dehydrogenase; Provisional; Region: PRK06841 393127001154 classical (c) SDRs; Region: SDR_c; cd05233 393127001155 NAD(P) binding site [chemical binding]; other site 393127001156 active site 393127001157 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393127001158 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 393127001159 substrate binding site [chemical binding]; other site 393127001160 dimer interface [polypeptide binding]; other site 393127001161 catalytic triad [active] 393127001162 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393127001163 DAK2 domain; Region: Dak2; cl03685 393127001164 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 393127001165 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393127001166 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 393127001167 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127001168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127001169 putative DNA binding site [nucleotide binding]; other site 393127001170 putative Zn2+ binding site [ion binding]; other site 393127001171 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127001172 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127001173 Coenzyme A binding pocket [chemical binding]; other site 393127001174 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 393127001175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393127001176 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 393127001177 acyl-activating enzyme (AAE) consensus motif; other site 393127001178 acyl-activating enzyme (AAE) consensus motif; other site 393127001179 AMP binding site [chemical binding]; other site 393127001180 active site 393127001181 CoA binding site [chemical binding]; other site 393127001182 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 393127001183 L-aspartate oxidase; Provisional; Region: PRK06175 393127001184 putative oxidoreductase; Provisional; Region: PRK10206 393127001185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127001186 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393127001187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001188 active site 393127001189 phosphorylation site [posttranslational modification] 393127001190 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 393127001191 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127001192 active site 393127001193 P-loop; other site 393127001194 phosphorylation site [posttranslational modification] 393127001195 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127001196 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393127001197 intersubunit interface [polypeptide binding]; other site 393127001198 active site 393127001199 zinc binding site [ion binding]; other site 393127001200 Na+ binding site [ion binding]; other site 393127001201 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127001202 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 393127001203 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127001204 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 393127001205 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 393127001206 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 393127001207 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 393127001208 Imelysin; Region: Peptidase_M75; pfam09375 393127001209 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 393127001210 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 393127001211 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 393127001212 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 393127001213 nudix motif; other site 393127001214 hypothetical protein; Provisional; Region: PRK12378 393127001215 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 393127001216 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 393127001217 PhnA protein; Region: PhnA; pfam03831 393127001218 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127001219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127001220 DNA-binding site [nucleotide binding]; DNA binding site 393127001221 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393127001222 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127001223 beta-galactosidase; Region: BGL; TIGR03356 393127001224 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127001225 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 393127001226 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127001227 active site 393127001228 P-loop; other site 393127001229 phosphorylation site [posttranslational modification] 393127001230 Predicted transcriptional regulator [Transcription]; Region: COG2378 393127001231 HTH domain; Region: HTH_11; pfam08279 393127001232 WYL domain; Region: WYL; pfam13280 393127001233 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 393127001234 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127001235 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127001236 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 393127001237 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 393127001238 tetrameric interface [polypeptide binding]; other site 393127001239 NAD binding site [chemical binding]; other site 393127001240 catalytic residues [active] 393127001241 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 393127001242 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 393127001243 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 393127001244 substrate binding site [chemical binding]; other site 393127001245 ATP binding site [chemical binding]; other site 393127001246 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 393127001247 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393127001248 PYR/PP interface [polypeptide binding]; other site 393127001249 dimer interface [polypeptide binding]; other site 393127001250 TPP binding site [chemical binding]; other site 393127001251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393127001252 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 393127001253 TPP-binding site; other site 393127001254 Uncharacterized conserved protein [Function unknown]; Region: COG5646 393127001255 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 393127001256 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 393127001257 ligand binding site [chemical binding]; other site 393127001258 active site 393127001259 UGI interface [polypeptide binding]; other site 393127001260 catalytic site [active] 393127001261 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 393127001262 hypothetical protein; Provisional; Region: PRK13665 393127001263 NlpC/P60 family; Region: NLPC_P60; pfam00877 393127001264 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127001265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127001266 Coenzyme A binding pocket [chemical binding]; other site 393127001267 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 393127001268 pyrroline-5-carboxylate reductase; Region: PLN02688 393127001269 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 393127001270 putative hydrophobic ligand binding site [chemical binding]; other site 393127001271 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001272 active site 393127001273 phosphorylation site [posttranslational modification] 393127001274 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127001275 alpha-mannosidase; Provisional; Region: PRK09819 393127001276 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393127001277 active site 393127001278 metal binding site [ion binding]; metal-binding site 393127001279 catalytic site [active] 393127001280 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393127001281 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127001282 HTH domain; Region: HTH_11; pfam08279 393127001283 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127001284 PRD domain; Region: PRD; pfam00874 393127001285 PRD domain; Region: PRD; pfam00874 393127001286 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127001287 active site 393127001288 P-loop; other site 393127001289 phosphorylation site [posttranslational modification] 393127001290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001291 active site 393127001292 phosphorylation site [posttranslational modification] 393127001293 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 393127001294 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 393127001295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127001296 putative metal binding site [ion binding]; other site 393127001297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 393127001298 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 393127001299 trimer interface [polypeptide binding]; other site 393127001300 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127001301 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 393127001302 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127001303 Leucine-rich repeats; other site 393127001304 Substrate binding site [chemical binding]; other site 393127001305 LRR adjacent; Region: LRR_adjacent; pfam08191 393127001306 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127001307 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127001308 phosphoenolpyruvate synthase; Validated; Region: PRK06241 393127001309 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393127001310 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 393127001311 ZIP Zinc transporter; Region: Zip; pfam02535 393127001312 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 393127001313 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 393127001314 NodB motif; other site 393127001315 active site 393127001316 catalytic site [active] 393127001317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127001318 non-specific DNA binding site [nucleotide binding]; other site 393127001319 salt bridge; other site 393127001320 sequence-specific DNA binding site [nucleotide binding]; other site 393127001321 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 393127001322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001323 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 393127001324 active site 393127001325 motif I; other site 393127001326 motif II; other site 393127001327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001328 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393127001329 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 393127001330 Predicted transcriptional regulators [Transcription]; Region: COG1695 393127001331 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 393127001332 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393127001333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393127001334 DNA binding residues [nucleotide binding] 393127001335 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 393127001336 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127001337 HTH domain; Region: HTH_11; pfam08279 393127001338 PRD domain; Region: PRD; pfam00874 393127001339 PRD domain; Region: PRD; pfam00874 393127001340 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127001341 active site 393127001342 P-loop; other site 393127001343 phosphorylation site [posttranslational modification] 393127001344 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001345 active site 393127001346 phosphorylation site [posttranslational modification] 393127001347 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001348 active site 393127001349 phosphorylation site [posttranslational modification] 393127001350 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127001351 active site 393127001352 P-loop; other site 393127001353 phosphorylation site [posttranslational modification] 393127001354 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127001355 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393127001356 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393127001357 active site 393127001358 metal binding site [ion binding]; metal-binding site 393127001359 catalytic site [active] 393127001360 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 393127001361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127001362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127001363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393127001364 dimerization interface [polypeptide binding]; other site 393127001365 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 393127001366 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 393127001367 active site 393127001368 substrate binding site [chemical binding]; other site 393127001369 trimer interface [polypeptide binding]; other site 393127001370 CoA binding site [chemical binding]; other site 393127001371 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 393127001372 classical (c) SDRs; Region: SDR_c; cd05233 393127001373 NAD(P) binding site [chemical binding]; other site 393127001374 active site 393127001375 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127001376 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001377 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127001378 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001379 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001380 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001381 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001382 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001383 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001384 LRR adjacent; Region: LRR_adjacent; pfam08191 393127001385 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127001386 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127001387 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 393127001388 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127001389 Leucine rich repeat; Region: LRR_8; pfam13855 393127001390 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127001391 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001392 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001393 LRR adjacent; Region: LRR_adjacent; pfam08191 393127001394 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 393127001395 SH3-like domain; Region: SH3_8; pfam13457 393127001396 Predicted transcriptional regulator [Transcription]; Region: COG1959 393127001397 Transcriptional regulator; Region: Rrf2; pfam02082 393127001398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393127001399 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 393127001400 NAD(P) binding site [chemical binding]; other site 393127001401 active site 393127001402 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 393127001403 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 393127001404 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 393127001405 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 393127001406 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393127001407 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393127001408 Transcriptional regulator [Transcription]; Region: LytR; COG1316 393127001409 Predicted membrane protein [Function unknown]; Region: COG1511 393127001410 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393127001411 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 393127001412 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 393127001413 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 393127001414 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127001415 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 393127001416 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 393127001417 active site 393127001418 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393127001419 L-tyrosine decarboxylase; Provisional; Region: PRK13520 393127001420 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127001421 catalytic residue [active] 393127001422 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 393127001423 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 393127001424 Predicted membrane protein [Function unknown]; Region: COG3619 393127001425 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 393127001426 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 393127001427 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 393127001428 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 393127001429 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 393127001430 Protein of unknown function DUF58; Region: DUF58; pfam01882 393127001431 MoxR-like ATPases [General function prediction only]; Region: COG0714 393127001432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127001433 Walker A motif; other site 393127001434 ATP binding site [chemical binding]; other site 393127001435 Walker B motif; other site 393127001436 arginine finger; other site 393127001437 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 393127001438 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 393127001439 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 393127001440 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 393127001441 Na binding site [ion binding]; other site 393127001442 Uncharacterized conserved protein [Function unknown]; Region: COG3535 393127001443 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 393127001444 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127001445 nucleotide binding site [chemical binding]; other site 393127001446 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 393127001447 Protein of unknown function (DUF585); Region: DUF585; pfam04522 393127001448 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 393127001449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127001450 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 393127001451 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 393127001452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393127001453 FeS/SAM binding site; other site 393127001454 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 393127001455 VanZ like family; Region: VanZ; pfam04892 393127001456 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 393127001457 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 393127001458 putative FMN binding site [chemical binding]; other site 393127001459 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 393127001460 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 393127001461 nudix motif; other site 393127001462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127001463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127001464 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393127001465 putative dimerization interface [polypeptide binding]; other site 393127001466 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 393127001467 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 393127001468 active site 393127001469 FMN binding site [chemical binding]; other site 393127001470 substrate binding site [chemical binding]; other site 393127001471 putative catalytic residue [active] 393127001472 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 393127001473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127001474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127001475 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 393127001476 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393127001477 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393127001478 shikimate binding site; other site 393127001479 NAD(P) binding site [chemical binding]; other site 393127001480 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 393127001481 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 393127001482 active site 393127001483 catalytic residue [active] 393127001484 dimer interface [polypeptide binding]; other site 393127001485 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127001486 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127001487 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 393127001488 dimerization interface [polypeptide binding]; other site 393127001489 substrate binding pocket [chemical binding]; other site 393127001490 Predicted acyl esterases [General function prediction only]; Region: COG2936 393127001491 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 393127001492 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 393127001493 active site 393127001494 catalytic triad [active] 393127001495 oxyanion hole [active] 393127001496 EamA-like transporter family; Region: EamA; pfam00892 393127001497 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 393127001498 EamA-like transporter family; Region: EamA; pfam00892 393127001499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 393127001500 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393127001501 active site 393127001502 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393127001503 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127001504 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127001505 substrate binding site [chemical binding]; other site 393127001506 hexamer interface [polypeptide binding]; other site 393127001507 metal binding site [ion binding]; metal-binding site 393127001508 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 393127001509 catalytic residue [active] 393127001510 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127001511 PRD domain; Region: PRD; pfam00874 393127001512 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127001513 active site 393127001514 P-loop; other site 393127001515 phosphorylation site [posttranslational modification] 393127001516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001517 active site 393127001518 phosphorylation site [posttranslational modification] 393127001519 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 393127001520 putative active site [active] 393127001521 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001522 active site 393127001523 phosphorylation site [posttranslational modification] 393127001524 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127001525 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127001526 substrate binding site [chemical binding]; other site 393127001527 hexamer interface [polypeptide binding]; other site 393127001528 metal binding site [ion binding]; metal-binding site 393127001529 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393127001530 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 393127001531 putative NAD(P) binding site [chemical binding]; other site 393127001532 catalytic Zn binding site [ion binding]; other site 393127001533 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393127001534 active site 393127001535 P-loop; other site 393127001536 phosphorylation site [posttranslational modification] 393127001537 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393127001538 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393127001539 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 393127001540 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 393127001541 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127001542 active site 393127001543 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 393127001544 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 393127001545 catalytic triad [active] 393127001546 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 393127001547 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127001548 MarR family; Region: MarR_2; pfam12802 393127001549 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001550 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127001551 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393127001552 Ligand Binding Site [chemical binding]; other site 393127001553 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 393127001554 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 393127001555 putative active site [active] 393127001556 putative metal binding site [ion binding]; other site 393127001557 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127001558 catalytic core [active] 393127001559 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127001560 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 393127001561 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754 393127001562 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909 393127001563 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 393127001564 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 393127001565 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 393127001566 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 393127001567 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 393127001568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393127001569 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 393127001570 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 393127001571 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 393127001572 Predicted membrane protein [Function unknown]; Region: COG3759 393127001573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127001574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127001575 putative substrate translocation pore; other site 393127001576 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393127001577 non-specific DNA interactions [nucleotide binding]; other site 393127001578 DNA binding site [nucleotide binding] 393127001579 sequence specific DNA binding site [nucleotide binding]; other site 393127001580 putative cAMP binding site [chemical binding]; other site 393127001581 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127001582 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393127001583 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 393127001584 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 393127001585 NAD binding site [chemical binding]; other site 393127001586 sugar binding site [chemical binding]; other site 393127001587 divalent metal binding site [ion binding]; other site 393127001588 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127001589 dimer interface [polypeptide binding]; other site 393127001590 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127001591 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127001592 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127001593 putative active site [active] 393127001594 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 393127001595 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 393127001596 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393127001597 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 393127001598 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393127001599 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393127001600 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 393127001601 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 393127001602 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393127001603 DNA binding residues [nucleotide binding] 393127001604 dimer interface [polypeptide binding]; other site 393127001605 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 393127001606 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 393127001607 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 393127001608 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 393127001609 DXD motif; other site 393127001610 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 393127001611 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 393127001612 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393127001613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127001614 S-adenosylmethionine binding site [chemical binding]; other site 393127001615 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 393127001616 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 393127001617 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127001618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127001619 DNA binding site [nucleotide binding] 393127001620 domain linker motif; other site 393127001621 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 393127001622 putative dimerization interface [polypeptide binding]; other site 393127001623 putative ligand binding site [chemical binding]; other site 393127001624 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 393127001625 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 393127001626 NAD binding site [chemical binding]; other site 393127001627 sugar binding site [chemical binding]; other site 393127001628 divalent metal binding site [ion binding]; other site 393127001629 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127001630 dimer interface [polypeptide binding]; other site 393127001631 allantoate amidohydrolase; Reviewed; Region: PRK09290 393127001632 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 393127001633 active site 393127001634 metal binding site [ion binding]; metal-binding site 393127001635 dimer interface [polypeptide binding]; other site 393127001636 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393127001637 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 393127001638 metal binding site [ion binding]; metal-binding site 393127001639 putative dimer interface [polypeptide binding]; other site 393127001640 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 393127001641 Beta-lactamase; Region: Beta-lactamase; pfam00144 393127001642 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 393127001643 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 393127001644 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 393127001645 intersubunit interface [polypeptide binding]; other site 393127001646 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 393127001647 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 393127001648 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 393127001649 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 393127001650 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 393127001651 Glucitol operon activator protein (GutM); Region: GutM; cl01890 393127001652 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 393127001653 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127001654 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 393127001655 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393127001656 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393127001657 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127001658 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001659 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001660 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001661 WxL domain surface cell wall-binding; Region: WxL; pfam13731 393127001662 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127001663 WxL domain surface cell wall-binding; Region: WxL; pfam13731 393127001664 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 393127001665 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 393127001666 FOG: CBS domain [General function prediction only]; Region: COG0517 393127001667 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 393127001668 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 393127001669 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 393127001670 dimer interface [polypeptide binding]; other site 393127001671 active site 393127001672 metal binding site [ion binding]; metal-binding site 393127001673 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 393127001674 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127001675 putative substrate translocation pore; other site 393127001676 POT family; Region: PTR2; pfam00854 393127001677 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127001678 catalytic core [active] 393127001679 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127001680 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127001681 catalytic core [active] 393127001682 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 393127001683 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 393127001684 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393127001685 Cl binding site [ion binding]; other site 393127001686 oligomer interface [polypeptide binding]; other site 393127001687 glutamate dehydrogenase; Provisional; Region: PRK09414 393127001688 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 393127001689 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 393127001690 NAD(P) binding site [chemical binding]; other site 393127001691 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 393127001692 metal binding site [ion binding]; metal-binding site 393127001693 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 393127001694 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 393127001695 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 393127001696 substrate binding site [chemical binding]; other site 393127001697 glutamase interaction surface [polypeptide binding]; other site 393127001698 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 393127001699 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 393127001700 catalytic residues [active] 393127001701 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 393127001702 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 393127001703 putative active site [active] 393127001704 oxyanion strand; other site 393127001705 catalytic triad [active] 393127001706 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 393127001707 putative active site pocket [active] 393127001708 4-fold oligomerization interface [polypeptide binding]; other site 393127001709 metal binding residues [ion binding]; metal-binding site 393127001710 3-fold/trimer interface [polypeptide binding]; other site 393127001711 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 393127001712 histidinol dehydrogenase; Region: hisD; TIGR00069 393127001713 NAD binding site [chemical binding]; other site 393127001714 dimerization interface [polypeptide binding]; other site 393127001715 product binding site; other site 393127001716 substrate binding site [chemical binding]; other site 393127001717 zinc binding site [ion binding]; other site 393127001718 catalytic residues [active] 393127001719 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 393127001720 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 393127001721 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 393127001722 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 393127001723 dimer interface [polypeptide binding]; other site 393127001724 motif 1; other site 393127001725 active site 393127001726 motif 2; other site 393127001727 motif 3; other site 393127001728 histidinol-phosphatase; Reviewed; Region: PRK08123 393127001729 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 393127001730 active site 393127001731 dimer interface [polypeptide binding]; other site 393127001732 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393127001733 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393127001734 DNA binding site [nucleotide binding] 393127001735 active site 393127001736 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 393127001737 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393127001738 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127001739 beta-galactosidase; Region: BGL; TIGR03356 393127001740 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127001741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127001742 DNA-binding site [nucleotide binding]; DNA binding site 393127001743 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393127001744 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001745 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127001746 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 393127001747 Uncharacterized conserved protein [Function unknown]; Region: COG2966 393127001748 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 393127001749 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 393127001750 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 393127001751 Predicted esterase [General function prediction only]; Region: COG0400 393127001752 putative hydrolase; Provisional; Region: PRK11460 393127001753 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 393127001754 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 393127001755 putative RNA binding site [nucleotide binding]; other site 393127001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127001757 S-adenosylmethionine binding site [chemical binding]; other site 393127001758 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 393127001759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127001760 Bacterial SH3 domain; Region: SH3_3; pfam08239 393127001761 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127001762 NlpC/P60 family; Region: NLPC_P60; pfam00877 393127001763 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 393127001764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393127001765 ATP binding site [chemical binding]; other site 393127001766 putative Mg++ binding site [ion binding]; other site 393127001767 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 393127001768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 393127001769 nucleotide binding region [chemical binding]; other site 393127001770 ATP-binding site [chemical binding]; other site 393127001771 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393127001772 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393127001773 WxL domain surface cell wall-binding; Region: WxL; pfam13731 393127001774 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 393127001775 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 393127001776 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 393127001777 DNA photolyase; Region: DNA_photolyase; pfam00875 393127001778 Predicted membrane protein [Function unknown]; Region: COG4852 393127001779 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 393127001780 DAK2 domain; Region: Dak2; pfam02734 393127001781 EDD domain protein, DegV family; Region: DegV; TIGR00762 393127001782 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393127001783 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 393127001784 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 393127001785 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 393127001786 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 393127001787 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 393127001788 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393127001789 homodimer interface [polypeptide binding]; other site 393127001790 substrate-cofactor binding pocket; other site 393127001791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127001792 catalytic residue [active] 393127001793 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 393127001794 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127001795 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393127001796 ligand binding site [chemical binding]; other site 393127001797 flexible hinge region; other site 393127001798 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127001799 BioY family; Region: BioY; pfam02632 393127001800 Predicted transcriptional regulators [Transcription]; Region: COG1695 393127001801 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 393127001802 Predicted membrane protein [Function unknown]; Region: COG4709 393127001803 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393127001804 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127001805 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127001806 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127001807 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127001808 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393127001809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127001810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393127001811 Coenzyme A binding pocket [chemical binding]; other site 393127001812 Tic20-like protein; Region: Tic20; pfam09685 393127001813 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 393127001814 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393127001815 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393127001816 MarR family; Region: MarR_2; pfam12802 393127001817 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127001818 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127001819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127001820 Walker A/P-loop; other site 393127001821 ATP binding site [chemical binding]; other site 393127001822 Q-loop/lid; other site 393127001823 ABC transporter signature motif; other site 393127001824 Walker B; other site 393127001825 D-loop; other site 393127001826 H-loop/switch region; other site 393127001827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127001828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127001829 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 393127001830 Walker A/P-loop; other site 393127001831 ATP binding site [chemical binding]; other site 393127001832 Q-loop/lid; other site 393127001833 ABC transporter signature motif; other site 393127001834 Walker B; other site 393127001835 D-loop; other site 393127001836 H-loop/switch region; other site 393127001837 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393127001838 active site residue [active] 393127001839 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001840 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127001841 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393127001842 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393127001843 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393127001844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127001845 putative DNA binding site [nucleotide binding]; other site 393127001846 putative Zn2+ binding site [ion binding]; other site 393127001847 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 393127001848 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 393127001849 putative NAD(P) binding site [chemical binding]; other site 393127001850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393127001851 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393127001852 Coenzyme A binding pocket [chemical binding]; other site 393127001853 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 393127001854 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393127001855 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 393127001856 putative active site [active] 393127001857 catalytic site [active] 393127001858 putative metal binding site [ion binding]; other site 393127001859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 393127001860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 393127001861 active site 393127001862 ATP binding site [chemical binding]; other site 393127001863 substrate binding site [chemical binding]; other site 393127001864 activation loop (A-loop); other site 393127001865 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 393127001866 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 393127001867 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393127001868 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127001869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127001870 Coenzyme A binding pocket [chemical binding]; other site 393127001871 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 393127001872 active site 393127001873 catalytic triad [active] 393127001874 oxyanion hole [active] 393127001875 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393127001876 domain interaction interfaces [polypeptide binding]; other site 393127001877 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393127001878 domain interaction interfaces [polypeptide binding]; other site 393127001879 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393127001880 domain interaction interfaces [polypeptide binding]; other site 393127001881 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 393127001882 domain interaction interfaces [polypeptide binding]; other site 393127001883 Isochorismatase family; Region: Isochorismatase; pfam00857 393127001884 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 393127001885 catalytic triad [active] 393127001886 conserved cis-peptide bond; other site 393127001887 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127001888 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127001889 PRD domain; Region: PRD; pfam00874 393127001890 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127001891 active site 393127001892 P-loop; other site 393127001893 phosphorylation site [posttranslational modification] 393127001894 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 393127001895 active site 393127001896 phosphorylation site [posttranslational modification] 393127001897 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127001898 active site 393127001899 phosphorylation site [posttranslational modification] 393127001900 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 393127001901 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127001902 active site 393127001903 P-loop; other site 393127001904 phosphorylation site [posttranslational modification] 393127001905 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 393127001906 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 393127001907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001908 motif II; other site 393127001909 Predicted transcriptional regulator [Transcription]; Region: COG1959 393127001910 Transcriptional regulator; Region: Rrf2; pfam02082 393127001911 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393127001912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127001913 S-adenosylmethionine binding site [chemical binding]; other site 393127001914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393127001915 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 393127001916 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 393127001917 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127001918 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127001919 active site 393127001920 catalytic tetrad [active] 393127001921 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 393127001922 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127001923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001924 motif II; other site 393127001925 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 393127001926 catalytic residue [active] 393127001927 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 393127001928 Sulfatase; Region: Sulfatase; pfam00884 393127001929 amino acid transporter; Region: 2A0306; TIGR00909 393127001930 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 393127001931 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 393127001932 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 393127001933 putative metal binding site [ion binding]; other site 393127001934 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 393127001935 active site 393127001936 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 393127001937 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393127001938 Cl binding site [ion binding]; other site 393127001939 oligomer interface [polypeptide binding]; other site 393127001940 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393127001941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127001942 DNA-binding site [nucleotide binding]; DNA binding site 393127001943 Predicted membrane protein [Function unknown]; Region: COG1511 393127001944 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393127001945 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 393127001946 linker region; other site 393127001947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127001948 Transcriptional regulators [Transcription]; Region: FadR; COG2186 393127001949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127001950 DNA-binding site [nucleotide binding]; DNA binding site 393127001951 FCD domain; Region: FCD; cl11656 393127001952 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393127001953 Predicted integral membrane protein [Function unknown]; Region: COG5523 393127001954 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393127001955 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 393127001956 active site 393127001957 metal binding site [ion binding]; metal-binding site 393127001958 Predicted membrane protein [Function unknown]; Region: COG2322 393127001959 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 393127001960 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393127001961 minor groove reading motif; other site 393127001962 helix-hairpin-helix signature motif; other site 393127001963 substrate binding pocket [chemical binding]; other site 393127001964 active site 393127001965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127001966 non-specific DNA binding site [nucleotide binding]; other site 393127001967 salt bridge; other site 393127001968 sequence-specific DNA binding site [nucleotide binding]; other site 393127001969 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393127001970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393127001971 Helix-turn-helix domain; Region: HTH_28; pfam13518 393127001972 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 393127001973 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 393127001974 dimer interface [polypeptide binding]; other site 393127001975 substrate binding site [chemical binding]; other site 393127001976 ATP binding site [chemical binding]; other site 393127001977 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127001978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001979 active site 393127001980 motif I; other site 393127001981 motif II; other site 393127001982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127001983 maltose O-acetyltransferase; Provisional; Region: PRK10092 393127001984 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 393127001985 active site 393127001986 substrate binding site [chemical binding]; other site 393127001987 trimer interface [polypeptide binding]; other site 393127001988 CoA binding site [chemical binding]; other site 393127001989 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 393127001990 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127001991 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127001992 Walker A/P-loop; other site 393127001993 ATP binding site [chemical binding]; other site 393127001994 Q-loop/lid; other site 393127001995 ABC transporter signature motif; other site 393127001996 Walker B; other site 393127001997 D-loop; other site 393127001998 H-loop/switch region; other site 393127001999 inner membrane transport permease; Provisional; Region: PRK15066 393127002000 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393127002001 oxidoreductase; Provisional; Region: PRK07985 393127002002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393127002003 NAD(P) binding site [chemical binding]; other site 393127002004 active site 393127002005 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 393127002006 Predicted membrane protein [Function unknown]; Region: COG3152 393127002007 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 393127002008 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 393127002009 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 393127002010 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 393127002011 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 393127002012 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 393127002013 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 393127002014 FHIPEP family; Region: FHIPEP; pfam00771 393127002015 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 393127002016 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393127002017 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 393127002018 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393127002019 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 393127002020 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 393127002021 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 393127002022 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 393127002023 flagellar motor protein MotA; Validated; Region: PRK08124 393127002024 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 393127002025 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 393127002026 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 393127002027 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 393127002028 ligand binding site [chemical binding]; other site 393127002029 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 393127002030 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 393127002031 putative metal binding site; other site 393127002032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127002033 binding surface 393127002034 TPR motif; other site 393127002035 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 393127002036 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 393127002037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127002038 active site 393127002039 phosphorylation site [posttranslational modification] 393127002040 intermolecular recognition site; other site 393127002041 dimerization interface [polypeptide binding]; other site 393127002042 flagellin; Provisional; Region: PRK12805 393127002043 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 393127002044 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 393127002045 Response regulator receiver domain; Region: Response_reg; pfam00072 393127002046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127002047 active site 393127002048 phosphorylation site [posttranslational modification] 393127002049 intermolecular recognition site; other site 393127002050 dimerization interface [polypeptide binding]; other site 393127002051 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 393127002052 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 393127002053 putative binding surface; other site 393127002054 active site 393127002055 P2 response regulator binding domain; Region: P2; pfam07194 393127002056 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 393127002057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127002058 ATP binding site [chemical binding]; other site 393127002059 Mg2+ binding site [ion binding]; other site 393127002060 G-X-G motif; other site 393127002061 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 393127002062 flagellar motor switch protein; Validated; Region: PRK06788 393127002063 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 393127002064 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 393127002065 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 393127002066 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 393127002067 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 393127002068 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 393127002069 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393127002070 flagellar motor switch protein; Validated; Region: PRK06789 393127002071 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 393127002072 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 393127002073 flagellar motor switch protein; Reviewed; Region: PRK06782 393127002074 CheC-like family; Region: CheC; pfam04509 393127002075 CheC-like family; Region: CheC; pfam04509 393127002076 Chemotaxis phosphatase CheX; Region: CheX; cl15816 393127002077 CheC-like family; Region: CheC; pfam04509 393127002078 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 393127002079 Protein of unknown function (DUF327); Region: DUF327; pfam03885 393127002080 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 393127002081 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393127002082 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 393127002083 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 393127002084 flagellar capping protein; Validated; Region: fliD; PRK06798 393127002085 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 393127002086 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 393127002087 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 393127002088 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 393127002089 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 393127002090 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 393127002091 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 393127002092 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 393127002093 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 393127002094 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 393127002095 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 393127002096 FliG C-terminal domain; Region: FliG_C; pfam01706 393127002097 flagellar assembly protein H; Validated; Region: fliH; PRK06800 393127002098 Flagellar assembly protein FliH; Region: FliH; pfam02108 393127002099 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 393127002100 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393127002101 Walker A motif; other site 393127002102 ATP binding site [chemical binding]; other site 393127002103 Walker B motif; other site 393127002104 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 393127002105 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 393127002106 N-acetyl-D-glucosamine binding site [chemical binding]; other site 393127002107 catalytic residue [active] 393127002108 Predicted transcriptional regulators [Transcription]; Region: COG1695 393127002109 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 393127002110 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 393127002111 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 393127002112 pyruvate oxidase; Provisional; Region: PRK08611 393127002113 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 393127002114 PYR/PP interface [polypeptide binding]; other site 393127002115 dimer interface [polypeptide binding]; other site 393127002116 tetramer interface [polypeptide binding]; other site 393127002117 TPP binding site [chemical binding]; other site 393127002118 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393127002119 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 393127002120 TPP-binding site [chemical binding]; other site 393127002121 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 393127002122 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 393127002123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127002124 dimerization interface [polypeptide binding]; other site 393127002125 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 393127002126 dimer interface [polypeptide binding]; other site 393127002127 putative CheW interface [polypeptide binding]; other site 393127002128 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 393127002129 putative active site [active] 393127002130 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 393127002131 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 393127002132 glutaminase active site [active] 393127002133 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393127002134 dimer interface [polypeptide binding]; other site 393127002135 active site 393127002136 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393127002137 dimer interface [polypeptide binding]; other site 393127002138 active site 393127002139 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 393127002140 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 393127002141 active site 393127002142 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 393127002143 GIY-YIG motif/motif A; other site 393127002144 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127002145 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127002146 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393127002148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127002149 non-specific DNA binding site [nucleotide binding]; other site 393127002150 salt bridge; other site 393127002151 sequence-specific DNA binding site [nucleotide binding]; other site 393127002152 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127002153 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127002154 DNA binding site [nucleotide binding] 393127002155 domain linker motif; other site 393127002156 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127002157 ligand binding site [chemical binding]; other site 393127002158 dimerization interface [polypeptide binding]; other site 393127002159 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127002160 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127002161 substrate binding site [chemical binding]; other site 393127002162 hexamer interface [polypeptide binding]; other site 393127002163 metal binding site [ion binding]; metal-binding site 393127002164 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 393127002165 BtpA family; Region: BtpA; cl00440 393127002166 Protein of unknown function (DUF556); Region: DUF556; cl00822 393127002167 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393127002168 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127002169 active site turn [active] 393127002170 phosphorylation site [posttranslational modification] 393127002171 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127002172 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393127002173 HPr interaction site; other site 393127002174 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127002175 active site 393127002176 phosphorylation site [posttranslational modification] 393127002177 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127002178 beta-galactosidase; Region: BGL; TIGR03356 393127002179 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127002180 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127002181 ligand binding site [chemical binding]; other site 393127002182 flexible hinge region; other site 393127002183 Predicted transcriptional regulators [Transcription]; Region: COG1725 393127002184 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002185 DNA-binding site [nucleotide binding]; DNA binding site 393127002186 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393127002187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127002188 Walker A/P-loop; other site 393127002189 ATP binding site [chemical binding]; other site 393127002190 Q-loop/lid; other site 393127002191 ABC transporter signature motif; other site 393127002192 Walker B; other site 393127002193 D-loop; other site 393127002194 H-loop/switch region; other site 393127002195 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127002196 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127002197 Walker A/P-loop; other site 393127002198 ATP binding site [chemical binding]; other site 393127002199 Q-loop/lid; other site 393127002200 ABC transporter signature motif; other site 393127002201 Walker B; other site 393127002202 D-loop; other site 393127002203 H-loop/switch region; other site 393127002204 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127002205 FtsX-like permease family; Region: FtsX; pfam02687 393127002206 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393127002207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127002208 non-specific DNA binding site [nucleotide binding]; other site 393127002209 salt bridge; other site 393127002210 sequence-specific DNA binding site [nucleotide binding]; other site 393127002211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393127002212 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127002213 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393127002214 ligand binding site [chemical binding]; other site 393127002215 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393127002216 non-specific DNA interactions [nucleotide binding]; other site 393127002217 DNA binding site [nucleotide binding] 393127002218 sequence specific DNA binding site [nucleotide binding]; other site 393127002219 putative cAMP binding site [chemical binding]; other site 393127002220 SnoaL-like domain; Region: SnoaL_4; pfam13577 393127002221 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 393127002222 active site 393127002223 catalytic triad [active] 393127002224 oxyanion hole [active] 393127002225 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127002226 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127002227 Walker A/P-loop; other site 393127002228 ATP binding site [chemical binding]; other site 393127002229 Q-loop/lid; other site 393127002230 ABC transporter signature motif; other site 393127002231 Walker B; other site 393127002232 D-loop; other site 393127002233 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393127002234 H-loop/switch region; other site 393127002235 active site 393127002236 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 393127002237 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393127002238 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393127002239 Zn binding site [ion binding]; other site 393127002240 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393127002241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127002242 Zn binding site [ion binding]; other site 393127002243 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 393127002244 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127002245 Zn binding site [ion binding]; other site 393127002246 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 393127002247 Zn binding site [ion binding]; other site 393127002248 Predicted esterase [General function prediction only]; Region: COG0400 393127002249 putative hydrolase; Provisional; Region: PRK11460 393127002250 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 393127002251 GTPases [General function prediction only]; Region: HflX; COG2262 393127002252 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 393127002253 HflX GTPase family; Region: HflX; cd01878 393127002254 G1 box; other site 393127002255 GTP/Mg2+ binding site [chemical binding]; other site 393127002256 Switch I region; other site 393127002257 G2 box; other site 393127002258 G3 box; other site 393127002259 Switch II region; other site 393127002260 G4 box; other site 393127002261 G5 box; other site 393127002262 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 393127002263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393127002264 putative active site [active] 393127002265 putative metal binding site [ion binding]; other site 393127002266 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 393127002267 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393127002268 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 393127002269 Uncharacterized conserved protein [Function unknown]; Region: COG3538 393127002270 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 393127002271 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393127002272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002273 dimer interface [polypeptide binding]; other site 393127002274 conserved gate region; other site 393127002275 putative PBP binding loops; other site 393127002276 ABC-ATPase subunit interface; other site 393127002277 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127002278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002279 dimer interface [polypeptide binding]; other site 393127002280 conserved gate region; other site 393127002281 putative PBP binding loops; other site 393127002282 ABC-ATPase subunit interface; other site 393127002283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393127002284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 393127002285 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 393127002286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002287 DNA-binding site [nucleotide binding]; DNA binding site 393127002288 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127002289 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127002290 ligand binding site [chemical binding]; other site 393127002291 dimerization interface [polypeptide binding]; other site 393127002292 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393127002293 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002294 DNA-binding site [nucleotide binding]; DNA binding site 393127002295 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 393127002296 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 393127002297 putative NADP binding site [chemical binding]; other site 393127002298 putative dimer interface [polypeptide binding]; other site 393127002299 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 393127002300 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393127002301 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127002302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127002303 nucleotide binding site [chemical binding]; other site 393127002304 Predicted membrane protein [Function unknown]; Region: COG4811 393127002305 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 393127002306 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 393127002307 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393127002308 active site 393127002309 phosphorylation site [posttranslational modification] 393127002310 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127002311 active pocket/dimerization site; other site 393127002312 active site 393127002313 phosphorylation site [posttranslational modification] 393127002314 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 393127002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127002316 Walker A motif; other site 393127002317 ATP binding site [chemical binding]; other site 393127002318 Walker B motif; other site 393127002319 arginine finger; other site 393127002320 Transcriptional antiterminator [Transcription]; Region: COG3933 393127002321 PRD domain; Region: PRD; pfam00874 393127002322 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127002323 active pocket/dimerization site; other site 393127002324 active site 393127002325 phosphorylation site [posttranslational modification] 393127002326 PRD domain; Region: PRD; pfam00874 393127002327 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 393127002328 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393127002329 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 393127002330 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393127002331 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 393127002332 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393127002333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 393127002334 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 393127002335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 393127002336 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 393127002337 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393127002338 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 393127002339 putative deacylase active site [active] 393127002340 Predicted amidohydrolase [General function prediction only]; Region: COG0388 393127002341 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 393127002342 active site 393127002343 catalytic triad [active] 393127002344 dimer interface [polypeptide binding]; other site 393127002345 Protein of unknown function (DUF554); Region: DUF554; pfam04474 393127002346 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 393127002347 NADH(P)-binding; Region: NAD_binding_10; pfam13460 393127002348 NAD binding site [chemical binding]; other site 393127002349 substrate binding site [chemical binding]; other site 393127002350 putative active site [active] 393127002351 Predicted permeases [General function prediction only]; Region: RarD; COG2962 393127002352 EamA-like transporter family; Region: EamA; pfam00892 393127002353 Uncharacterized conserved protein [Function unknown]; Region: COG2353 393127002354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393127002355 MarR family; Region: MarR_2; pfam12802 393127002356 lysine transporter; Provisional; Region: PRK10836 393127002357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393127002358 PAS domain; Region: PAS_9; pfam13426 393127002359 putative active site [active] 393127002360 heme pocket [chemical binding]; other site 393127002361 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127002362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 393127002363 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393127002364 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393127002365 synthetase active site [active] 393127002366 NTP binding site [chemical binding]; other site 393127002367 metal binding site [ion binding]; metal-binding site 393127002368 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393127002369 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 393127002370 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393127002371 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127002372 non-specific DNA binding site [nucleotide binding]; other site 393127002373 salt bridge; other site 393127002374 sequence-specific DNA binding site [nucleotide binding]; other site 393127002375 Cupin domain; Region: Cupin_2; pfam07883 393127002376 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 393127002377 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 393127002378 Walker A/P-loop; other site 393127002379 ATP binding site [chemical binding]; other site 393127002380 Q-loop/lid; other site 393127002381 ABC transporter signature motif; other site 393127002382 Walker B; other site 393127002383 D-loop; other site 393127002384 H-loop/switch region; other site 393127002385 TOBE domain; Region: TOBE_2; pfam08402 393127002386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 393127002387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002388 putative PBP binding loops; other site 393127002389 ABC-ATPase subunit interface; other site 393127002390 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 393127002391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002392 dimer interface [polypeptide binding]; other site 393127002393 conserved gate region; other site 393127002394 putative PBP binding loops; other site 393127002395 ABC-ATPase subunit interface; other site 393127002396 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 393127002397 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 393127002398 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 393127002399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127002400 Walker A motif; other site 393127002401 ATP binding site [chemical binding]; other site 393127002402 Walker B motif; other site 393127002403 arginine finger; other site 393127002404 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 393127002405 active site 393127002406 catalytic triad [active] 393127002407 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 393127002408 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 393127002409 putative active site [active] 393127002410 putative NTP binding site [chemical binding]; other site 393127002411 putative nucleic acid binding site [nucleotide binding]; other site 393127002412 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 393127002413 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 393127002414 active site 393127002415 zinc binding site [ion binding]; other site 393127002416 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393127002417 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127002418 Zn2+ binding site [ion binding]; other site 393127002419 Mg2+ binding site [ion binding]; other site 393127002420 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127002421 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127002422 nucleotide binding site [chemical binding]; other site 393127002423 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 393127002424 FMN binding site [chemical binding]; other site 393127002425 substrate binding site [chemical binding]; other site 393127002426 putative catalytic residue [active] 393127002427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127002428 MarR family; Region: MarR_2; pfam12802 393127002429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393127002430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127002431 Coenzyme A binding pocket [chemical binding]; other site 393127002432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393127002433 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393127002434 dimer interface [polypeptide binding]; other site 393127002435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127002436 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 393127002437 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393127002438 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127002439 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393127002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127002441 motif II; other site 393127002442 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393127002443 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127002444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127002445 Coenzyme A binding pocket [chemical binding]; other site 393127002446 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 393127002447 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127002448 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127002449 DNA binding residues [nucleotide binding] 393127002450 putative dimer interface [polypeptide binding]; other site 393127002451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127002452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127002453 active site 393127002454 catalytic tetrad [active] 393127002455 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 393127002456 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 393127002457 homodimer interface [polypeptide binding]; other site 393127002458 catalytic residues [active] 393127002459 NAD binding site [chemical binding]; other site 393127002460 substrate binding pocket [chemical binding]; other site 393127002461 flexible flap; other site 393127002462 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 393127002463 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 393127002464 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 393127002465 PhoU domain; Region: PhoU; pfam01895 393127002466 PhoU domain; Region: PhoU; pfam01895 393127002467 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 393127002468 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 393127002469 dimer interface [polypeptide binding]; other site 393127002470 PYR/PP interface [polypeptide binding]; other site 393127002471 TPP binding site [chemical binding]; other site 393127002472 substrate binding site [chemical binding]; other site 393127002473 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 393127002474 Domain of unknown function; Region: EKR; smart00890 393127002475 4Fe-4S binding domain; Region: Fer4_6; pfam12837 393127002476 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 393127002477 TPP-binding site [chemical binding]; other site 393127002478 dimer interface [polypeptide binding]; other site 393127002479 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 393127002480 Predicted permeases [General function prediction only]; Region: COG0679 393127002481 Helix-turn-helix domain; Region: HTH_28; pfam13518 393127002482 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127002483 non-specific DNA binding site [nucleotide binding]; other site 393127002484 salt bridge; other site 393127002485 sequence-specific DNA binding site [nucleotide binding]; other site 393127002486 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393127002487 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127002488 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127002489 Predicted membrane protein [Function unknown]; Region: COG3223 393127002490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127002491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127002492 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 393127002493 Walker A/P-loop; other site 393127002494 ATP binding site [chemical binding]; other site 393127002495 Q-loop/lid; other site 393127002496 ABC transporter signature motif; other site 393127002497 Walker B; other site 393127002498 D-loop; other site 393127002499 H-loop/switch region; other site 393127002500 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 393127002501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002502 putative substrate translocation pore; other site 393127002503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127002506 putative substrate translocation pore; other site 393127002507 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127002508 MarR family; Region: MarR; pfam01047 393127002509 MarR family; Region: MarR_2; cl17246 393127002510 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 393127002511 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393127002512 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127002513 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393127002514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127002515 motif II; other site 393127002516 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393127002517 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002518 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002519 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002520 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002521 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002522 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002523 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127002524 Predicted membrane protein [Function unknown]; Region: COG3326 393127002525 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 393127002526 homotrimer interaction site [polypeptide binding]; other site 393127002527 putative active site [active] 393127002528 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 393127002529 substrate binding site [chemical binding]; other site 393127002530 zinc-binding site [ion binding]; other site 393127002531 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 393127002532 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 393127002533 GIY-YIG motif/motif A; other site 393127002534 active site 393127002535 catalytic site [active] 393127002536 putative DNA binding site [nucleotide binding]; other site 393127002537 metal binding site [ion binding]; metal-binding site 393127002538 UvrB/uvrC motif; Region: UVR; pfam02151 393127002539 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393127002540 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393127002541 substrate binding pocket [chemical binding]; other site 393127002542 membrane-bound complex binding site; other site 393127002543 hinge residues; other site 393127002544 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393127002545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002546 dimer interface [polypeptide binding]; other site 393127002547 conserved gate region; other site 393127002548 putative PBP binding loops; other site 393127002549 ABC-ATPase subunit interface; other site 393127002550 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393127002551 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393127002552 Walker A/P-loop; other site 393127002553 ATP binding site [chemical binding]; other site 393127002554 Q-loop/lid; other site 393127002555 ABC transporter signature motif; other site 393127002556 Walker B; other site 393127002557 D-loop; other site 393127002558 H-loop/switch region; other site 393127002559 amidase; Provisional; Region: PRK11910 393127002560 Amidase; Region: Amidase; cl11426 393127002561 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127002562 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127002563 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 393127002564 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 393127002565 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 393127002566 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 393127002567 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 393127002568 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 393127002569 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393127002570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393127002571 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 393127002572 Esterase/lipase [General function prediction only]; Region: COG1647 393127002573 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127002574 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127002575 DNA binding site [nucleotide binding] 393127002576 domain linker motif; other site 393127002577 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 393127002578 putative dimerization interface [polypeptide binding]; other site 393127002579 putative ligand binding site [chemical binding]; other site 393127002580 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393127002581 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127002582 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 393127002583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002584 dimer interface [polypeptide binding]; other site 393127002585 conserved gate region; other site 393127002586 putative PBP binding loops; other site 393127002587 ABC-ATPase subunit interface; other site 393127002588 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127002589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127002590 dimer interface [polypeptide binding]; other site 393127002591 conserved gate region; other site 393127002592 ABC-ATPase subunit interface; other site 393127002593 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393127002594 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393127002595 Ca binding site [ion binding]; other site 393127002596 active site 393127002597 catalytic site [active] 393127002598 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 393127002599 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 393127002600 active site 393127002601 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 393127002602 active site 393127002603 substrate binding site [chemical binding]; other site 393127002604 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 393127002605 metal binding site [ion binding]; metal-binding site 393127002606 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393127002607 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393127002608 ATP binding site [chemical binding]; other site 393127002609 Mg++ binding site [ion binding]; other site 393127002610 motif III; other site 393127002611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127002612 nucleotide binding region [chemical binding]; other site 393127002613 ATP-binding site [chemical binding]; other site 393127002614 Predicted membrane protein [Function unknown]; Region: COG4708 393127002615 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 393127002616 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 393127002617 Predicted transcriptional regulators [Transcription]; Region: COG1733 393127002618 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 393127002619 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 393127002620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002621 putative substrate translocation pore; other site 393127002622 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127002623 PRD domain; Region: PRD; pfam00874 393127002624 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127002625 active site 393127002626 P-loop; other site 393127002627 phosphorylation site [posttranslational modification] 393127002628 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127002629 active site 393127002630 phosphorylation site [posttranslational modification] 393127002631 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127002632 methionine cluster; other site 393127002633 active site 393127002634 phosphorylation site [posttranslational modification] 393127002635 metal binding site [ion binding]; metal-binding site 393127002636 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127002637 active site 393127002638 P-loop; other site 393127002639 phosphorylation site [posttranslational modification] 393127002640 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127002641 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127002642 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393127002643 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393127002644 active site 393127002645 trimer interface [polypeptide binding]; other site 393127002646 allosteric site; other site 393127002647 active site lid [active] 393127002648 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393127002649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127002650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127002651 active site 393127002652 catalytic tetrad [active] 393127002653 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 393127002654 Collagen binding domain; Region: Collagen_bind; pfam05737 393127002655 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 393127002656 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127002657 Uncharacterized conserved protein [Function unknown]; Region: COG3402 393127002658 Predicted membrane protein [Function unknown]; Region: COG3428 393127002659 Bacterial PH domain; Region: DUF304; pfam03703 393127002660 Bacterial PH domain; Region: DUF304; pfam03703 393127002661 Bacterial PH domain; Region: DUF304; pfam03703 393127002662 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 393127002663 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 393127002664 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 393127002665 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 393127002666 active site 393127002667 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393127002668 dimer interface [polypeptide binding]; other site 393127002669 substrate binding site [chemical binding]; other site 393127002670 catalytic residues [active] 393127002671 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 393127002672 PemK-like protein; Region: PemK; pfam02452 393127002673 Rsbr N terminal; Region: Rsbr_N; pfam08678 393127002674 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127002675 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127002676 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 393127002677 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 393127002678 ATP binding site [chemical binding]; other site 393127002679 Mg2+ binding site [ion binding]; other site 393127002680 G-X-G motif; other site 393127002681 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 393127002682 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 393127002683 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 393127002684 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 393127002685 anti sigma factor interaction site; other site 393127002686 regulatory phosphorylation site [posttranslational modification]; other site 393127002687 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 393127002688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127002689 ATP binding site [chemical binding]; other site 393127002690 Mg2+ binding site [ion binding]; other site 393127002691 G-X-G motif; other site 393127002692 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 393127002693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393127002694 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 393127002695 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393127002696 DNA binding residues [nucleotide binding] 393127002697 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 393127002698 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 393127002699 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 393127002700 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393127002701 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 393127002702 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 393127002703 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 393127002704 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 393127002705 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 393127002706 RNA binding site [nucleotide binding]; other site 393127002707 hypothetical protein; Provisional; Region: PRK04351 393127002708 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 393127002709 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 393127002710 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 393127002711 Uncharacterized conserved protein [Function unknown]; Region: COG5646 393127002712 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127002713 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127002714 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127002715 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002716 DNA-binding site [nucleotide binding]; DNA binding site 393127002717 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393127002718 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 393127002719 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 393127002720 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 393127002721 glutathione reductase; Validated; Region: PRK06116 393127002722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127002723 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127002724 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393127002725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127002726 catalytic core [active] 393127002727 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393127002728 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393127002729 Predicted transcriptional regulators [Transcription]; Region: COG1725 393127002730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002731 DNA-binding site [nucleotide binding]; DNA binding site 393127002732 Predicted membrane protein [General function prediction only]; Region: COG4194 393127002733 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 393127002734 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 393127002735 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 393127002736 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 393127002737 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 393127002738 tetramerization interface [polypeptide binding]; other site 393127002739 NAD(P) binding site [chemical binding]; other site 393127002740 catalytic residues [active] 393127002741 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 393127002742 active site 393127002743 P-loop; other site 393127002744 phosphorylation site [posttranslational modification] 393127002745 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127002746 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127002747 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127002748 methionine cluster; other site 393127002749 active site 393127002750 phosphorylation site [posttranslational modification] 393127002751 metal binding site [ion binding]; metal-binding site 393127002752 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127002753 beta-galactosidase; Region: BGL; TIGR03356 393127002754 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127002755 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127002756 PRD domain; Region: PRD; pfam00874 393127002757 PRD domain; Region: PRD; pfam00874 393127002758 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127002759 active site 393127002760 phosphorylation site [posttranslational modification] 393127002761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127002762 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 393127002763 ABC transporter; Region: ABC_tran_2; pfam12848 393127002764 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127002765 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 393127002766 Predicted permeases [General function prediction only]; Region: COG0701 393127002767 Predicted membrane protein [Function unknown]; Region: COG3689 393127002768 pantothenate kinase; Provisional; Region: PRK05439 393127002769 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 393127002770 ATP-binding site [chemical binding]; other site 393127002771 CoA-binding site [chemical binding]; other site 393127002772 Mg2+-binding site [ion binding]; other site 393127002773 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 393127002774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127002775 Walker A/P-loop; other site 393127002776 ATP binding site [chemical binding]; other site 393127002777 Q-loop/lid; other site 393127002778 ABC transporter signature motif; other site 393127002779 Walker B; other site 393127002780 D-loop; other site 393127002781 H-loop/switch region; other site 393127002782 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393127002783 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393127002784 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127002785 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127002786 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 393127002787 Domain of unknown function (DUF373); Region: DUF373; cl12079 393127002788 Sulfatase; Region: Sulfatase; pfam00884 393127002789 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 393127002790 active site 393127002791 DNA binding site [nucleotide binding] 393127002792 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 393127002793 active site 393127002794 catalytic site [active] 393127002795 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 393127002796 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393127002797 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 393127002798 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 393127002799 Uncharacterized conserved protein [Function unknown]; Region: COG0398 393127002800 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393127002801 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393127002802 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393127002803 Ligand binding site; other site 393127002804 Putative Catalytic site; other site 393127002805 DXD motif; other site 393127002806 epoxyqueuosine reductase; Region: TIGR00276 393127002807 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 393127002808 A new structural DNA glycosylase; Region: AlkD_like; cl11434 393127002809 active site 393127002810 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 393127002811 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 393127002812 dimer interface [polypeptide binding]; other site 393127002813 FMN binding site [chemical binding]; other site 393127002814 NADPH bind site [chemical binding]; other site 393127002815 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393127002816 Low molecular weight phosphatase family; Region: LMWPc; cd00115 393127002817 active site 393127002818 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 393127002819 HSP90 family protein; Provisional; Region: PRK14083 393127002820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127002821 ATP binding site [chemical binding]; other site 393127002822 Mg2+ binding site [ion binding]; other site 393127002823 G-X-G motif; other site 393127002824 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 393127002825 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 393127002826 dimerization interface [polypeptide binding]; other site 393127002827 DPS ferroxidase diiron center [ion binding]; other site 393127002828 ion pore; other site 393127002829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 393127002830 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 393127002831 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127002832 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 393127002833 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 393127002834 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 393127002835 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 393127002836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002837 putative substrate translocation pore; other site 393127002838 Transcriptional regulators [Transcription]; Region: FadR; COG2186 393127002839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002840 DNA-binding site [nucleotide binding]; DNA binding site 393127002841 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 393127002842 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393127002843 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393127002844 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 393127002845 PGAP1-like protein; Region: PGAP1; pfam07819 393127002846 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 393127002847 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 393127002848 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 393127002849 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 393127002850 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 393127002851 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 393127002852 active site 393127002853 dimer interface [polypeptide binding]; other site 393127002854 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393127002855 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393127002856 active site 393127002857 trimer interface [polypeptide binding]; other site 393127002858 allosteric site; other site 393127002859 active site lid [active] 393127002860 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393127002861 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127002862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127002863 DNA-binding site [nucleotide binding]; DNA binding site 393127002864 UTRA domain; Region: UTRA; pfam07702 393127002865 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 393127002866 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 393127002867 Mg++ binding site [ion binding]; other site 393127002868 putative catalytic motif [active] 393127002869 substrate binding site [chemical binding]; other site 393127002870 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 393127002871 Peptidase family U32; Region: Peptidase_U32; pfam01136 393127002872 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 393127002873 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393127002874 Peptidase family U32; Region: Peptidase_U32; pfam01136 393127002875 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 393127002876 heat shock protein HtpX; Provisional; Region: PRK04897 393127002877 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 393127002878 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 393127002879 catalytic residues [active] 393127002880 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 393127002881 putative active site [active] 393127002882 putative metal binding residues [ion binding]; other site 393127002883 signature motif; other site 393127002884 putative triphosphate binding site [ion binding]; other site 393127002885 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127002886 TPR motif; other site 393127002887 binding surface 393127002888 TPR repeat; Region: TPR_11; pfam13414 393127002889 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393127002890 synthetase active site [active] 393127002891 NTP binding site [chemical binding]; other site 393127002892 metal binding site [ion binding]; metal-binding site 393127002893 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 393127002894 ATP-NAD kinase; Region: NAD_kinase; pfam01513 393127002895 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393127002896 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393127002897 active site 393127002898 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 393127002899 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 393127002900 NAD binding site [chemical binding]; other site 393127002901 homotetramer interface [polypeptide binding]; other site 393127002902 homodimer interface [polypeptide binding]; other site 393127002903 substrate binding site [chemical binding]; other site 393127002904 active site 393127002905 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 393127002906 DltD N-terminal region; Region: DltD_N; pfam04915 393127002907 DltD central region; Region: DltD_M; pfam04918 393127002908 DltD C-terminal region; Region: DltD_C; pfam04914 393127002909 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 393127002910 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 393127002911 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 393127002912 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 393127002913 acyl-activating enzyme (AAE) consensus motif; other site 393127002914 AMP binding site [chemical binding]; other site 393127002915 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 393127002916 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127002917 active site 393127002918 dimer interface [polypeptide binding]; other site 393127002919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127002920 Coenzyme A binding pocket [chemical binding]; other site 393127002921 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 393127002922 Putative esterase; Region: Esterase; pfam00756 393127002923 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 393127002924 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 393127002925 homodimer interface [polypeptide binding]; other site 393127002926 substrate-cofactor binding pocket; other site 393127002927 catalytic residue [active] 393127002928 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393127002929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127002930 Walker A/P-loop; other site 393127002931 ATP binding site [chemical binding]; other site 393127002932 Q-loop/lid; other site 393127002933 ABC transporter signature motif; other site 393127002934 Walker B; other site 393127002935 D-loop; other site 393127002936 H-loop/switch region; other site 393127002937 ABC-2 type transporter; Region: ABC2_membrane; cl17235 393127002938 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 393127002939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127002940 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127002941 putative substrate translocation pore; other site 393127002942 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393127002943 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 393127002944 putative oligomer interface [polypeptide binding]; other site 393127002945 putative active site [active] 393127002946 metal binding site [ion binding]; metal-binding site 393127002947 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 393127002948 catalytic residues [active] 393127002949 dimer interface [polypeptide binding]; other site 393127002950 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 393127002951 LytTr DNA-binding domain; Region: LytTR; pfam04397 393127002952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127002954 Walker A/P-loop; other site 393127002955 ATP binding site [chemical binding]; other site 393127002956 Q-loop/lid; other site 393127002957 ABC transporter signature motif; other site 393127002958 Walker B; other site 393127002959 D-loop; other site 393127002960 H-loop/switch region; other site 393127002961 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 393127002962 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393127002963 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 393127002964 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 393127002965 G1 box; other site 393127002966 putative GEF interaction site [polypeptide binding]; other site 393127002967 GTP/Mg2+ binding site [chemical binding]; other site 393127002968 Switch I region; other site 393127002969 G2 box; other site 393127002970 G3 box; other site 393127002971 Switch II region; other site 393127002972 G4 box; other site 393127002973 G5 box; other site 393127002974 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 393127002975 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127002976 MarR family; Region: MarR_2; cl17246 393127002977 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393127002978 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393127002979 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 393127002980 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 393127002981 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 393127002982 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 393127002983 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 393127002984 Acyltransferase family; Region: Acyl_transf_3; pfam01757 393127002985 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393127002986 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393127002987 DNA binding site [nucleotide binding] 393127002988 active site 393127002989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127002990 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 393127002991 Walker A motif; other site 393127002992 ATP binding site [chemical binding]; other site 393127002993 Walker B motif; other site 393127002994 arginine finger; other site 393127002995 UvrB/uvrC motif; Region: UVR; pfam02151 393127002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127002997 Walker A motif; other site 393127002998 ATP binding site [chemical binding]; other site 393127002999 Walker B motif; other site 393127003000 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 393127003001 CAAX protease self-immunity; Region: Abi; pfam02517 393127003002 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 393127003003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393127003004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 393127003005 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 393127003006 dimerization domain swap beta strand [polypeptide binding]; other site 393127003007 regulatory protein interface [polypeptide binding]; other site 393127003008 active site 393127003009 regulatory phosphorylation site [posttranslational modification]; other site 393127003010 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 393127003011 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 393127003012 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393127003013 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 393127003014 putative transposase OrfB; Reviewed; Region: PHA02517 393127003015 HTH-like domain; Region: HTH_21; pfam13276 393127003016 Integrase core domain; Region: rve; pfam00665 393127003017 Integrase core domain; Region: rve_3; cl15866 393127003018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 393127003019 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 393127003020 Uncharacterized conserved protein [Function unknown]; Region: COG1434 393127003021 putative active site [active] 393127003022 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 393127003023 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 393127003024 aminotransferase A; Validated; Region: PRK07683 393127003025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127003026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127003027 homodimer interface [polypeptide binding]; other site 393127003028 catalytic residue [active] 393127003029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 393127003030 FOG: CBS domain [General function prediction only]; Region: COG0517 393127003031 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 393127003032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127003033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127003034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393127003035 dimerization interface [polypeptide binding]; other site 393127003036 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 393127003037 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 393127003038 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393127003039 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393127003040 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393127003041 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 393127003042 metal binding site [ion binding]; metal-binding site 393127003043 putative dimer interface [polypeptide binding]; other site 393127003044 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 393127003045 Mechanosensitive ion channel; Region: MS_channel; pfam00924 393127003046 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 393127003047 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127003048 Walker A/P-loop; other site 393127003049 ATP binding site [chemical binding]; other site 393127003050 Q-loop/lid; other site 393127003051 ABC transporter signature motif; other site 393127003052 Walker B; other site 393127003053 D-loop; other site 393127003054 H-loop/switch region; other site 393127003055 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393127003056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127003057 dimer interface [polypeptide binding]; other site 393127003058 conserved gate region; other site 393127003059 putative PBP binding loops; other site 393127003060 ABC-ATPase subunit interface; other site 393127003061 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 393127003062 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393127003063 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393127003064 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 393127003065 HPr interaction site; other site 393127003066 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127003067 active site 393127003068 phosphorylation site [posttranslational modification] 393127003069 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 393127003070 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 393127003071 S1 domain; Region: S1_2; pfam13509 393127003072 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 393127003073 RNA binding site [nucleotide binding]; other site 393127003074 Predicted membrane protein [Function unknown]; Region: COG4758 393127003075 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 393127003076 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 393127003077 Histidine kinase; Region: HisKA_3; pfam07730 393127003078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127003079 ATP binding site [chemical binding]; other site 393127003080 Mg2+ binding site [ion binding]; other site 393127003081 G-X-G motif; other site 393127003082 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 393127003083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127003084 active site 393127003085 phosphorylation site [posttranslational modification] 393127003086 intermolecular recognition site; other site 393127003087 dimerization interface [polypeptide binding]; other site 393127003088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 393127003089 DNA binding residues [nucleotide binding] 393127003090 dimerization interface [polypeptide binding]; other site 393127003091 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 393127003092 TrkA-N domain; Region: TrkA_N; pfam02254 393127003093 TrkA-C domain; Region: TrkA_C; pfam02080 393127003094 Predicted membrane protein [Function unknown]; Region: COG1289 393127003095 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 393127003096 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 393127003097 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 393127003098 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393127003099 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 393127003100 hypothetical protein; Provisional; Region: PRK13667 393127003101 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127003102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127003103 active site 393127003104 motif I; other site 393127003105 motif II; other site 393127003106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127003107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127003108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127003109 DNA binding site [nucleotide binding] 393127003110 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127003111 ligand binding site [chemical binding]; other site 393127003112 dimerization interface [polypeptide binding]; other site 393127003113 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 393127003114 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393127003115 trimer interface [polypeptide binding]; other site 393127003116 substrate binding site [chemical binding]; other site 393127003117 Mn binding site [ion binding]; other site 393127003118 transketolase; Reviewed; Region: PRK05899 393127003119 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393127003120 TPP-binding site [chemical binding]; other site 393127003121 dimer interface [polypeptide binding]; other site 393127003122 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 393127003123 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393127003124 PYR/PP interface [polypeptide binding]; other site 393127003125 dimer interface [polypeptide binding]; other site 393127003126 TPP binding site [chemical binding]; other site 393127003127 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127003128 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 393127003129 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 393127003130 nucleotide binding site [chemical binding]; other site 393127003131 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393127003132 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127003133 active site turn [active] 393127003134 phosphorylation site [posttranslational modification] 393127003135 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127003136 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393127003137 HPr interaction site; other site 393127003138 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127003139 active site 393127003140 phosphorylation site [posttranslational modification] 393127003141 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 393127003142 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 393127003143 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 393127003144 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 393127003145 GTP binding site; other site 393127003146 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 393127003147 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 393127003148 Walker A/P-loop; other site 393127003149 ATP binding site [chemical binding]; other site 393127003150 Q-loop/lid; other site 393127003151 ABC transporter signature motif; other site 393127003152 Walker B; other site 393127003153 D-loop; other site 393127003154 H-loop/switch region; other site 393127003155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127003156 dimer interface [polypeptide binding]; other site 393127003157 conserved gate region; other site 393127003158 putative PBP binding loops; other site 393127003159 ABC-ATPase subunit interface; other site 393127003160 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 393127003161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 393127003162 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 393127003163 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 393127003164 dimer interface [polypeptide binding]; other site 393127003165 putative functional site; other site 393127003166 putative MPT binding site; other site 393127003167 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 393127003168 Walker A motif; other site 393127003169 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 393127003170 MoaE homodimer interface [polypeptide binding]; other site 393127003171 MoaD interaction [polypeptide binding]; other site 393127003172 active site residues [active] 393127003173 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 393127003174 MoaE interaction surface [polypeptide binding]; other site 393127003175 MoeB interaction surface [polypeptide binding]; other site 393127003176 thiocarboxylated glycine; other site 393127003177 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 393127003178 trimer interface [polypeptide binding]; other site 393127003179 dimer interface [polypeptide binding]; other site 393127003180 putative active site [active] 393127003181 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 393127003182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393127003183 FeS/SAM binding site; other site 393127003184 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 393127003185 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 393127003186 MPT binding site; other site 393127003187 trimer interface [polypeptide binding]; other site 393127003188 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 393127003189 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 393127003190 ATP binding site [chemical binding]; other site 393127003191 substrate interface [chemical binding]; other site 393127003192 Flavin Reductases; Region: FlaRed; cl00801 393127003193 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 393127003194 active site 393127003195 catalytic residues [active] 393127003196 metal binding site [ion binding]; metal-binding site 393127003197 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 393127003198 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 393127003199 TPP-binding site [chemical binding]; other site 393127003200 tetramer interface [polypeptide binding]; other site 393127003201 heterodimer interface [polypeptide binding]; other site 393127003202 phosphorylation loop region [posttranslational modification] 393127003203 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 393127003204 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 393127003205 alpha subunit interface [polypeptide binding]; other site 393127003206 TPP binding site [chemical binding]; other site 393127003207 heterodimer interface [polypeptide binding]; other site 393127003208 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127003209 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 393127003210 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393127003211 E3 interaction surface; other site 393127003212 lipoyl attachment site [posttranslational modification]; other site 393127003213 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393127003214 E3 interaction surface; other site 393127003215 lipoyl attachment site [posttranslational modification]; other site 393127003216 e3 binding domain; Region: E3_binding; pfam02817 393127003217 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393127003218 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 393127003219 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393127003220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127003221 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393127003222 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 393127003223 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 393127003224 NAD(P) binding site [chemical binding]; other site 393127003225 LDH/MDH dimer interface [polypeptide binding]; other site 393127003226 substrate binding site [chemical binding]; other site 393127003227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 393127003228 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 393127003229 Thioredoxin; Region: Thioredoxin_4; pfam13462 393127003230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127003231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127003232 active site 393127003233 phosphorylation site [posttranslational modification] 393127003234 intermolecular recognition site; other site 393127003235 dimerization interface [polypeptide binding]; other site 393127003236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127003237 DNA binding site [nucleotide binding] 393127003238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393127003239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127003240 dimerization interface [polypeptide binding]; other site 393127003241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127003242 dimer interface [polypeptide binding]; other site 393127003243 phosphorylation site [posttranslational modification] 393127003244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127003245 ATP binding site [chemical binding]; other site 393127003246 Mg2+ binding site [ion binding]; other site 393127003247 G-X-G motif; other site 393127003248 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127003249 FtsX-like permease family; Region: FtsX; pfam02687 393127003250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127003251 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127003252 Walker A/P-loop; other site 393127003253 ATP binding site [chemical binding]; other site 393127003254 Q-loop/lid; other site 393127003255 ABC transporter signature motif; other site 393127003256 Walker B; other site 393127003257 D-loop; other site 393127003258 H-loop/switch region; other site 393127003259 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 393127003260 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 393127003261 Cl binding site [ion binding]; other site 393127003262 oligomer interface [polypeptide binding]; other site 393127003263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 393127003264 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 393127003265 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 393127003266 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 393127003267 active site 393127003268 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 393127003269 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 393127003270 G1 box; other site 393127003271 putative GEF interaction site [polypeptide binding]; other site 393127003272 GTP/Mg2+ binding site [chemical binding]; other site 393127003273 Switch I region; other site 393127003274 G2 box; other site 393127003275 G3 box; other site 393127003276 Switch II region; other site 393127003277 G4 box; other site 393127003278 G5 box; other site 393127003279 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 393127003280 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 393127003281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 393127003282 hypothetical protein; Provisional; Region: PRK13666 393127003283 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393127003284 pyruvate carboxylase; Reviewed; Region: PRK12999 393127003285 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393127003286 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393127003287 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 393127003288 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 393127003289 active site 393127003290 catalytic residues [active] 393127003291 metal binding site [ion binding]; metal-binding site 393127003292 homodimer binding site [polypeptide binding]; other site 393127003293 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 393127003294 carboxyltransferase (CT) interaction site; other site 393127003295 biotinylation site [posttranslational modification]; other site 393127003296 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 393127003297 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 393127003298 putative binding site residues; other site 393127003299 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 393127003300 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 393127003301 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 393127003302 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 393127003303 Walker A/P-loop; other site 393127003304 ATP binding site [chemical binding]; other site 393127003305 Q-loop/lid; other site 393127003306 ABC transporter signature motif; other site 393127003307 Walker B; other site 393127003308 D-loop; other site 393127003309 H-loop/switch region; other site 393127003310 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127003311 SH3-like domain; Region: SH3_8; pfam13457 393127003312 SH3-like domain; Region: SH3_8; pfam13457 393127003313 SH3-like domain; Region: SH3_8; pfam13457 393127003314 SH3-like domain; Region: SH3_8; pfam13457 393127003315 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393127003316 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 393127003317 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 393127003318 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 393127003319 active site 393127003320 tetramer interface; other site 393127003321 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 393127003322 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 393127003323 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 393127003324 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393127003325 active site 393127003326 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 393127003327 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 393127003328 substrate binding site; other site 393127003329 tetramer interface; other site 393127003330 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 393127003331 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 393127003332 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 393127003333 NAD binding site [chemical binding]; other site 393127003334 substrate binding site [chemical binding]; other site 393127003335 homodimer interface [polypeptide binding]; other site 393127003336 active site 393127003337 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 393127003338 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 393127003339 NADP binding site [chemical binding]; other site 393127003340 active site 393127003341 putative substrate binding site [chemical binding]; other site 393127003342 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393127003343 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 393127003344 substrate binding site; other site 393127003345 dimer interface; other site 393127003346 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 393127003347 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393127003348 putative NAD(P) binding site [chemical binding]; other site 393127003349 putative catalytic Zn binding site [ion binding]; other site 393127003350 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 393127003351 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 393127003352 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 393127003353 active site 393127003354 putative glycosyl transferase; Provisional; Region: PRK10073 393127003355 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393127003356 active site 393127003357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 393127003358 active site 393127003359 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 393127003360 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 393127003361 active site 393127003362 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 393127003363 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 393127003364 homodimer interface [polypeptide binding]; other site 393127003365 NAD binding pocket [chemical binding]; other site 393127003366 ATP binding pocket [chemical binding]; other site 393127003367 Mg binding site [ion binding]; other site 393127003368 active-site loop [active] 393127003369 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393127003370 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 393127003371 active site 393127003372 P-loop; other site 393127003373 phosphorylation site [posttranslational modification] 393127003374 GMP synthase; Reviewed; Region: guaA; PRK00074 393127003375 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 393127003376 AMP/PPi binding site [chemical binding]; other site 393127003377 candidate oxyanion hole; other site 393127003378 catalytic triad [active] 393127003379 potential glutamine specificity residues [chemical binding]; other site 393127003380 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 393127003381 ATP Binding subdomain [chemical binding]; other site 393127003382 Dimerization subdomain; other site 393127003383 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 393127003384 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 393127003385 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 393127003386 Int/Topo IB signature motif; other site 393127003387 LXG domain of WXG superfamily; Region: LXG; pfam04740 393127003388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393127003389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393127003390 MepB protein; Region: MepB; cl01985 393127003391 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 393127003392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127003393 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127003394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127003395 Coenzyme A binding pocket [chemical binding]; other site 393127003396 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127003397 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 393127003398 DNA binding residues [nucleotide binding] 393127003399 drug binding residues [chemical binding]; other site 393127003400 dimer interface [polypeptide binding]; other site 393127003401 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 393127003402 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127003403 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127003404 Walker A/P-loop; other site 393127003405 ATP binding site [chemical binding]; other site 393127003406 Q-loop/lid; other site 393127003407 ABC transporter signature motif; other site 393127003408 Walker B; other site 393127003409 D-loop; other site 393127003410 H-loop/switch region; other site 393127003411 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127003412 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127003413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127003414 Walker A/P-loop; other site 393127003415 ATP binding site [chemical binding]; other site 393127003416 Q-loop/lid; other site 393127003417 ABC transporter signature motif; other site 393127003418 Walker B; other site 393127003419 D-loop; other site 393127003420 H-loop/switch region; other site 393127003421 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 393127003422 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127003423 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127003424 DNA binding residues [nucleotide binding] 393127003425 putative dimer interface [polypeptide binding]; other site 393127003426 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127003427 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 393127003428 LRR adjacent; Region: LRR_adjacent; pfam08191 393127003429 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127003430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 393127003431 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 393127003432 Clp protease; Region: CLP_protease; pfam00574 393127003433 oligomer interface [polypeptide binding]; other site 393127003434 active site residues [active] 393127003435 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393127003436 dimer interface [polypeptide binding]; other site 393127003437 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127003438 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 393127003439 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 393127003440 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 393127003441 SLBB domain; Region: SLBB; pfam10531 393127003442 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 393127003443 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 393127003444 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003445 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 393127003446 putative hexamer interface [polypeptide binding]; other site 393127003447 putative hexagonal pore; other site 393127003448 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 393127003449 putative hexamer interface [polypeptide binding]; other site 393127003450 putative hexagonal pore; other site 393127003451 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 393127003452 putative hexamer interface [polypeptide binding]; other site 393127003453 putative hexagonal pore; other site 393127003454 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 393127003455 G1 box; other site 393127003456 GTP/Mg2+ binding site [chemical binding]; other site 393127003457 G2 box; other site 393127003458 Switch I region; other site 393127003459 G3 box; other site 393127003460 Switch II region; other site 393127003461 G4 box; other site 393127003462 G5 box; other site 393127003463 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 393127003464 homotrimer interface [polypeptide binding]; other site 393127003465 Walker A motif; other site 393127003466 GTP binding site [chemical binding]; other site 393127003467 Walker B motif; other site 393127003468 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 393127003469 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127003470 catalytic core [active] 393127003471 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 393127003472 Sensory domain found in PocR; Region: PocR; pfam10114 393127003473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127003474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127003475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127003476 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003477 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393127003478 Hexamer interface [polypeptide binding]; other site 393127003479 Hexagonal pore residue; other site 393127003480 propanediol utilization protein PduB; Provisional; Region: PRK15415 393127003481 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 393127003482 putative hexamer interface [polypeptide binding]; other site 393127003483 putative hexagonal pore; other site 393127003484 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 393127003485 putative hexamer interface [polypeptide binding]; other site 393127003486 putative hexagonal pore; other site 393127003487 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 393127003488 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 393127003489 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 393127003490 alpha-beta subunit interface [polypeptide binding]; other site 393127003491 alpha-gamma subunit interface [polypeptide binding]; other site 393127003492 active site 393127003493 substrate and K+ binding site; other site 393127003494 K+ binding site [ion binding]; other site 393127003495 cobalamin binding site [chemical binding]; other site 393127003496 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 393127003497 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 393127003498 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 393127003499 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 393127003500 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003501 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 393127003502 putative hexamer interface [polypeptide binding]; other site 393127003503 putative hexagonal pore; other site 393127003504 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003505 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393127003506 Hexamer interface [polypeptide binding]; other site 393127003507 Hexagonal pore residue; other site 393127003508 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 393127003509 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393127003510 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393127003511 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 393127003512 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127003513 nucleotide binding site [chemical binding]; other site 393127003514 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 393127003515 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 393127003516 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 393127003517 Hexamer/Pentamer interface [polypeptide binding]; other site 393127003518 central pore; other site 393127003519 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 393127003520 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 393127003521 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 393127003522 putative catalytic cysteine [active] 393127003523 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 393127003524 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 393127003525 putative active site [active] 393127003526 metal binding site [ion binding]; metal-binding site 393127003527 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 393127003528 amphipathic channel; other site 393127003529 Asn-Pro-Ala signature motifs; other site 393127003530 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 393127003531 propionate/acetate kinase; Provisional; Region: PRK12379 393127003532 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 393127003533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127003534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127003535 homodimer interface [polypeptide binding]; other site 393127003536 catalytic residue [active] 393127003537 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 393127003538 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 393127003539 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 393127003540 putative active site [active] 393127003541 metal binding site [ion binding]; metal-binding site 393127003542 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 393127003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127003544 active site 393127003545 phosphorylation site [posttranslational modification] 393127003546 intermolecular recognition site; other site 393127003547 dimerization interface [polypeptide binding]; other site 393127003548 ANTAR domain; Region: ANTAR; pfam03861 393127003549 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 393127003550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 393127003551 Histidine kinase; Region: HisKA_2; pfam07568 393127003552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127003553 ATP binding site [chemical binding]; other site 393127003554 Mg2+ binding site [ion binding]; other site 393127003555 G-X-G motif; other site 393127003556 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 393127003557 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 393127003558 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 393127003559 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 393127003560 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 393127003561 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 393127003562 putative hexamer interface [polypeptide binding]; other site 393127003563 putative hexagonal pore; other site 393127003564 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 393127003565 putative hexamer interface [polypeptide binding]; other site 393127003566 putative hexagonal pore; other site 393127003567 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003568 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 393127003569 Hexamer interface [polypeptide binding]; other site 393127003570 Hexagonal pore residue; other site 393127003571 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 393127003572 putative catalytic cysteine [active] 393127003573 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 393127003574 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 393127003575 Hexamer interface [polypeptide binding]; other site 393127003576 Putative hexagonal pore residue; other site 393127003577 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 393127003578 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 393127003579 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393127003580 Propanediol utilisation protein PduL; Region: PduL; pfam06130 393127003581 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 393127003582 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 393127003583 Hexamer/Pentamer interface [polypeptide binding]; other site 393127003584 central pore; other site 393127003585 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 393127003586 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 393127003587 putative hexamer interface [polypeptide binding]; other site 393127003588 putative hexagonal pore; other site 393127003589 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 393127003590 putative hexamer interface [polypeptide binding]; other site 393127003591 putative hexagonal pore; other site 393127003592 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 393127003593 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 393127003594 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 393127003595 hypothetical protein; Region: PHA01818 393127003596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127003597 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127003598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127003599 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 393127003600 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 393127003601 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 393127003602 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 393127003603 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 393127003604 catalytic triad [active] 393127003605 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 393127003606 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 393127003607 Precorrin-8X methylmutase; Region: CbiC; pfam02570 393127003608 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 393127003609 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 393127003610 active site 393127003611 putative homodimer interface [polypeptide binding]; other site 393127003612 SAM binding site [chemical binding]; other site 393127003613 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 393127003614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127003615 S-adenosylmethionine binding site [chemical binding]; other site 393127003616 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 393127003617 active site 393127003618 SAM binding site [chemical binding]; other site 393127003619 homodimer interface [polypeptide binding]; other site 393127003620 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 393127003621 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 393127003622 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 393127003623 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 393127003624 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 393127003625 active site 393127003626 SAM binding site [chemical binding]; other site 393127003627 homodimer interface [polypeptide binding]; other site 393127003628 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 393127003629 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 393127003630 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 393127003631 active site 393127003632 SAM binding site [chemical binding]; other site 393127003633 homodimer interface [polypeptide binding]; other site 393127003634 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 393127003635 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 393127003636 active site 393127003637 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 393127003638 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 393127003639 active site 393127003640 C-terminal domain interface [polypeptide binding]; other site 393127003641 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 393127003642 active site 393127003643 N-terminal domain interface [polypeptide binding]; other site 393127003644 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 393127003645 active site 393127003646 SAM binding site [chemical binding]; other site 393127003647 homodimer interface [polypeptide binding]; other site 393127003648 cobalt transport protein CbiM; Validated; Region: PRK08319 393127003649 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 393127003650 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 393127003651 cobalt transport protein CbiQ; Provisional; Region: PRK15485 393127003652 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 393127003653 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393127003654 Walker A/P-loop; other site 393127003655 ATP binding site [chemical binding]; other site 393127003656 Q-loop/lid; other site 393127003657 ABC transporter signature motif; other site 393127003658 Walker B; other site 393127003659 D-loop; other site 393127003660 H-loop/switch region; other site 393127003661 cobyric acid synthase; Provisional; Region: PRK00784 393127003662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393127003663 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393127003664 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 393127003665 catalytic triad [active] 393127003666 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 393127003667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 393127003668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 393127003669 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 393127003670 AAA domain; Region: AAA_17; pfam13207 393127003671 Predicted transcriptional regulators [Transcription]; Region: COG1695 393127003672 Transcriptional regulator PadR-like family; Region: PadR; cl17335 393127003673 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 393127003674 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127003675 SH3-like domain; Region: SH3_8; pfam13457 393127003676 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127003677 SH3-like domain; Region: SH3_8; pfam13457 393127003678 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393127003679 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 393127003680 oligomer interface [polypeptide binding]; other site 393127003681 active site 393127003682 metal binding site [ion binding]; metal-binding site 393127003683 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 393127003684 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 393127003685 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 393127003686 Predicted transcriptional regulators [Transcription]; Region: COG1733 393127003687 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 393127003688 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 393127003689 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 393127003690 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 393127003691 dimer interface [polypeptide binding]; other site 393127003692 motif 1; other site 393127003693 active site 393127003694 motif 2; other site 393127003695 motif 3; other site 393127003696 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 393127003697 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 393127003698 putative tRNA-binding site [nucleotide binding]; other site 393127003699 B3/4 domain; Region: B3_4; pfam03483 393127003700 tRNA synthetase B5 domain; Region: B5; smart00874 393127003701 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 393127003702 dimer interface [polypeptide binding]; other site 393127003703 motif 1; other site 393127003704 motif 3; other site 393127003705 motif 2; other site 393127003706 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 393127003707 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127003708 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127003709 Walker A/P-loop; other site 393127003710 ATP binding site [chemical binding]; other site 393127003711 Q-loop/lid; other site 393127003712 ABC transporter signature motif; other site 393127003713 Walker B; other site 393127003714 D-loop; other site 393127003715 H-loop/switch region; other site 393127003716 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127003717 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 393127003718 FtsX-like permease family; Region: FtsX; pfam02687 393127003719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127003720 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127003721 FtsX-like permease family; Region: FtsX; pfam02687 393127003722 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393127003723 MarR family; Region: MarR_2; pfam12802 393127003724 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 393127003725 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 393127003726 ligand binding site [chemical binding]; other site 393127003727 active site 393127003728 UGI interface [polypeptide binding]; other site 393127003729 catalytic site [active] 393127003730 ribonuclease HIII; Provisional; Region: PRK00996 393127003731 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 393127003732 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 393127003733 RNA/DNA hybrid binding site [nucleotide binding]; other site 393127003734 active site 393127003735 Cell division protein ZapA; Region: ZapA; cl01146 393127003736 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 393127003737 Colicin V production protein; Region: Colicin_V; pfam02674 393127003738 hypothetical protein; Provisional; Region: PRK08609 393127003739 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 393127003740 active site 393127003741 primer binding site [nucleotide binding]; other site 393127003742 NTP binding site [chemical binding]; other site 393127003743 metal binding triad [ion binding]; metal-binding site 393127003744 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 393127003745 active site 393127003746 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 393127003747 MutS domain III; Region: MutS_III; pfam05192 393127003748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127003749 Walker A/P-loop; other site 393127003750 ATP binding site [chemical binding]; other site 393127003751 Q-loop/lid; other site 393127003752 ABC transporter signature motif; other site 393127003753 Walker B; other site 393127003754 D-loop; other site 393127003755 H-loop/switch region; other site 393127003756 Smr domain; Region: Smr; pfam01713 393127003757 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127003758 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393127003759 catalytic residues [active] 393127003760 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 393127003761 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 393127003762 GIY-YIG motif/motif A; other site 393127003763 active site 393127003764 catalytic site [active] 393127003765 putative DNA binding site [nucleotide binding]; other site 393127003766 metal binding site [ion binding]; metal-binding site 393127003767 UvrB/uvrC motif; Region: UVR; pfam02151 393127003768 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 393127003769 aspartate kinase; Reviewed; Region: PRK06635 393127003770 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 393127003771 putative nucleotide binding site [chemical binding]; other site 393127003772 putative catalytic residues [active] 393127003773 putative Mg ion binding site [ion binding]; other site 393127003774 putative aspartate binding site [chemical binding]; other site 393127003775 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 393127003776 putative allosteric regulatory site; other site 393127003777 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 393127003778 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 393127003779 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 393127003780 ribonuclease PH; Reviewed; Region: rph; PRK00173 393127003781 Ribonuclease PH; Region: RNase_PH_bact; cd11362 393127003782 hexamer interface [polypeptide binding]; other site 393127003783 active site 393127003784 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 393127003785 active site 393127003786 dimerization interface [polypeptide binding]; other site 393127003787 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 393127003788 active site 393127003789 metal binding site [ion binding]; metal-binding site 393127003790 homotetramer interface [polypeptide binding]; other site 393127003791 Uncharacterized conserved protein [Function unknown]; Region: COG5361 393127003792 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 393127003793 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 393127003794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 393127003795 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 393127003796 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 393127003797 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393127003798 dimer interface [polypeptide binding]; other site 393127003799 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 393127003800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127003801 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 393127003802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393127003803 ATP binding site [chemical binding]; other site 393127003804 Mg++ binding site [ion binding]; other site 393127003805 motif III; other site 393127003806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127003807 nucleotide binding region [chemical binding]; other site 393127003808 ATP-binding site [chemical binding]; other site 393127003809 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 393127003810 RNA binding site [nucleotide binding]; other site 393127003811 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393127003812 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 393127003813 putative active site [active] 393127003814 nucleotide binding site [chemical binding]; other site 393127003815 nudix motif; other site 393127003816 putative metal binding site [ion binding]; other site 393127003817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127003818 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127003819 putative substrate translocation pore; other site 393127003820 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127003821 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127003822 ligand binding site [chemical binding]; other site 393127003823 flexible hinge region; other site 393127003824 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127003825 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393127003826 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127003827 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127003828 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 393127003829 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127003830 DNA-binding site [nucleotide binding]; DNA binding site 393127003831 UTRA domain; Region: UTRA; pfam07702 393127003832 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 393127003833 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 393127003834 Ca binding site [ion binding]; other site 393127003835 active site 393127003836 catalytic site [active] 393127003837 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127003838 active site turn [active] 393127003839 phosphorylation site [posttranslational modification] 393127003840 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 393127003841 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127003842 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 393127003843 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 393127003844 nudix motif; other site 393127003845 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 393127003846 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127003847 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 393127003848 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 393127003849 putative catalytic cysteine [active] 393127003850 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 393127003851 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 393127003852 nucleotide binding site [chemical binding]; other site 393127003853 homotetrameric interface [polypeptide binding]; other site 393127003854 putative phosphate binding site [ion binding]; other site 393127003855 putative allosteric binding site; other site 393127003856 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 393127003857 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 393127003858 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393127003859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127003860 non-specific DNA binding site [nucleotide binding]; other site 393127003861 salt bridge; other site 393127003862 sequence-specific DNA binding site [nucleotide binding]; other site 393127003863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127003864 non-specific DNA binding site [nucleotide binding]; other site 393127003865 salt bridge; other site 393127003866 sequence-specific DNA binding site [nucleotide binding]; other site 393127003867 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 393127003868 active site 393127003869 trigger factor; Provisional; Region: tig; PRK01490 393127003870 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 393127003871 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 393127003872 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 393127003873 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 393127003874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127003875 Walker A motif; other site 393127003876 ATP binding site [chemical binding]; other site 393127003877 Walker B motif; other site 393127003878 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393127003879 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 393127003880 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393127003881 Catalytic site [active] 393127003882 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393127003883 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 393127003884 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393127003885 Catalytic site [active] 393127003886 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 393127003887 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 393127003888 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393127003889 Catalytic site [active] 393127003890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 393127003891 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 393127003892 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 393127003893 GTP/Mg2+ binding site [chemical binding]; other site 393127003894 G4 box; other site 393127003895 G5 box; other site 393127003896 G1 box; other site 393127003897 Switch I region; other site 393127003898 G2 box; other site 393127003899 G3 box; other site 393127003900 Switch II region; other site 393127003901 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 393127003902 RNA/DNA hybrid binding site [nucleotide binding]; other site 393127003903 active site 393127003904 DNA protecting protein DprA; Region: dprA; TIGR00732 393127003905 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 393127003906 DNA topoisomerase I; Validated; Region: PRK05582 393127003907 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 393127003908 active site 393127003909 interdomain interaction site; other site 393127003910 putative metal-binding site [ion binding]; other site 393127003911 nucleotide binding site [chemical binding]; other site 393127003912 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 393127003913 domain I; other site 393127003914 DNA binding groove [nucleotide binding] 393127003915 phosphate binding site [ion binding]; other site 393127003916 domain II; other site 393127003917 domain III; other site 393127003918 nucleotide binding site [chemical binding]; other site 393127003919 catalytic site [active] 393127003920 domain IV; other site 393127003921 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393127003922 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 393127003923 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 393127003924 Glucose inhibited division protein A; Region: GIDA; pfam01134 393127003925 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 393127003926 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 393127003927 active site 393127003928 DNA binding site [nucleotide binding] 393127003929 Int/Topo IB signature motif; other site 393127003930 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 393127003931 active site 393127003932 HslU subunit interaction site [polypeptide binding]; other site 393127003933 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 393127003934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127003935 Walker A motif; other site 393127003936 ATP binding site [chemical binding]; other site 393127003937 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 393127003938 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 393127003939 transcriptional repressor CodY; Validated; Region: PRK04158 393127003940 CodY GAF-like domain; Region: CodY; pfam06018 393127003941 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 393127003942 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 393127003943 active site 393127003944 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 393127003945 active site 393127003946 catalytic residues [active] 393127003947 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 393127003948 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 393127003949 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 393127003950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127003951 Mg2+ binding site [ion binding]; other site 393127003952 G-X-G motif; other site 393127003953 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 393127003954 anchoring element; other site 393127003955 dimer interface [polypeptide binding]; other site 393127003956 ATP binding site [chemical binding]; other site 393127003957 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 393127003958 active site 393127003959 putative metal-binding site [ion binding]; other site 393127003960 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 393127003961 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 393127003962 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 393127003963 CAP-like domain; other site 393127003964 active site 393127003965 primary dimer interface [polypeptide binding]; other site 393127003966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 393127003967 S-ribosylhomocysteinase; Provisional; Region: PRK02260 393127003968 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127003969 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127003970 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 393127003971 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 393127003972 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 393127003973 catalytic triad [active] 393127003974 catalytic triad [active] 393127003975 oxyanion hole [active] 393127003976 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 393127003977 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 393127003978 active site 393127003979 catalytic site [active] 393127003980 metal binding site [ion binding]; metal-binding site 393127003981 dimer interface [polypeptide binding]; other site 393127003982 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 393127003983 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 393127003984 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 393127003985 bacterial Hfq-like; Region: Hfq; cd01716 393127003986 hexamer interface [polypeptide binding]; other site 393127003987 Sm1 motif; other site 393127003988 RNA binding site [nucleotide binding]; other site 393127003989 Sm2 motif; other site 393127003990 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 393127003991 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 393127003992 HflX GTPase family; Region: HflX; cd01878 393127003993 G1 box; other site 393127003994 GTP/Mg2+ binding site [chemical binding]; other site 393127003995 Switch I region; other site 393127003996 G2 box; other site 393127003997 G3 box; other site 393127003998 Switch II region; other site 393127003999 G4 box; other site 393127004000 G5 box; other site 393127004001 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 393127004002 Aluminium resistance protein; Region: Alum_res; pfam06838 393127004003 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 393127004004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393127004005 DNA binding residues [nucleotide binding] 393127004006 putative dimer interface [polypeptide binding]; other site 393127004007 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 393127004008 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 393127004009 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 393127004010 arsenical pump membrane protein; Provisional; Region: PRK15445 393127004011 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 393127004012 transmembrane helices; other site 393127004013 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393127004014 LexA repressor; Validated; Region: PRK00215 393127004015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127004016 putative DNA binding site [nucleotide binding]; other site 393127004017 putative Zn2+ binding site [ion binding]; other site 393127004018 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 393127004019 Catalytic site [active] 393127004020 cell division suppressor protein YneA; Provisional; Region: PRK14125 393127004021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 393127004022 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 393127004023 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393127004024 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393127004025 TPP-binding site [chemical binding]; other site 393127004026 dimer interface [polypeptide binding]; other site 393127004027 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393127004028 PYR/PP interface [polypeptide binding]; other site 393127004029 dimer interface [polypeptide binding]; other site 393127004030 TPP binding site [chemical binding]; other site 393127004031 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127004032 hypothetical protein; Provisional; Region: PRK01844 393127004033 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 393127004034 Protein of unknown function (DUF970); Region: DUF970; cl17525 393127004035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393127004036 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393127004037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127004038 S-adenosylmethionine binding site [chemical binding]; other site 393127004039 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 393127004040 ParB-like nuclease domain; Region: ParBc; pfam02195 393127004041 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 393127004042 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 393127004043 Active Sites [active] 393127004044 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 393127004045 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393127004046 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 393127004047 putative nucleotide binding site [chemical binding]; other site 393127004048 uridine monophosphate binding site [chemical binding]; other site 393127004049 homohexameric interface [polypeptide binding]; other site 393127004050 ribosome recycling factor; Reviewed; Region: frr; PRK00083 393127004051 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 393127004052 hinge region; other site 393127004053 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 393127004054 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 393127004055 catalytic residue [active] 393127004056 putative FPP diphosphate binding site; other site 393127004057 putative FPP binding hydrophobic cleft; other site 393127004058 dimer interface [polypeptide binding]; other site 393127004059 putative IPP diphosphate binding site; other site 393127004060 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 393127004061 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 393127004062 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 393127004063 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 393127004064 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 393127004065 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 393127004066 RIP metalloprotease RseP; Region: TIGR00054 393127004067 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 393127004068 active site 393127004069 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 393127004070 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 393127004071 protein binding site [polypeptide binding]; other site 393127004072 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 393127004073 putative substrate binding region [chemical binding]; other site 393127004074 prolyl-tRNA synthetase; Provisional; Region: PRK09194 393127004075 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 393127004076 dimer interface [polypeptide binding]; other site 393127004077 motif 1; other site 393127004078 active site 393127004079 motif 2; other site 393127004080 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 393127004081 putative deacylase active site [active] 393127004082 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 393127004083 active site 393127004084 motif 3; other site 393127004085 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 393127004086 anticodon binding site; other site 393127004087 DNA polymerase III PolC; Validated; Region: polC; PRK00448 393127004088 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 393127004089 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 393127004090 generic binding surface II; other site 393127004091 generic binding surface I; other site 393127004092 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 393127004093 active site 393127004094 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 393127004095 active site 393127004096 catalytic site [active] 393127004097 substrate binding site [chemical binding]; other site 393127004098 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 393127004099 ribosome maturation protein RimP; Reviewed; Region: PRK00092 393127004100 Sm and related proteins; Region: Sm_like; cl00259 393127004101 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 393127004102 putative oligomer interface [polypeptide binding]; other site 393127004103 putative RNA binding site [nucleotide binding]; other site 393127004104 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 393127004105 NusA N-terminal domain; Region: NusA_N; pfam08529 393127004106 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 393127004107 RNA binding site [nucleotide binding]; other site 393127004108 homodimer interface [polypeptide binding]; other site 393127004109 NusA-like KH domain; Region: KH_5; pfam13184 393127004110 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 393127004111 G-X-X-G motif; other site 393127004112 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 393127004113 putative RNA binding cleft [nucleotide binding]; other site 393127004114 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 393127004115 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393127004116 translation initiation factor IF-2; Region: IF-2; TIGR00487 393127004117 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 393127004118 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 393127004119 G1 box; other site 393127004120 putative GEF interaction site [polypeptide binding]; other site 393127004121 GTP/Mg2+ binding site [chemical binding]; other site 393127004122 Switch I region; other site 393127004123 G2 box; other site 393127004124 G3 box; other site 393127004125 Switch II region; other site 393127004126 G4 box; other site 393127004127 G5 box; other site 393127004128 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 393127004129 Translation-initiation factor 2; Region: IF-2; pfam11987 393127004130 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 393127004131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 393127004132 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 393127004133 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 393127004134 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 393127004135 RNA binding site [nucleotide binding]; other site 393127004136 active site 393127004137 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 393127004138 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 393127004139 active site 393127004140 Riboflavin kinase; Region: Flavokinase; smart00904 393127004141 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 393127004142 16S/18S rRNA binding site [nucleotide binding]; other site 393127004143 S13e-L30e interaction site [polypeptide binding]; other site 393127004144 25S rRNA binding site [nucleotide binding]; other site 393127004145 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 393127004146 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 393127004147 RNase E interface [polypeptide binding]; other site 393127004148 trimer interface [polypeptide binding]; other site 393127004149 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 393127004150 RNase E interface [polypeptide binding]; other site 393127004151 trimer interface [polypeptide binding]; other site 393127004152 active site 393127004153 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 393127004154 putative nucleic acid binding region [nucleotide binding]; other site 393127004155 G-X-X-G motif; other site 393127004156 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 393127004157 RNA binding site [nucleotide binding]; other site 393127004158 domain interface; other site 393127004159 GTPase RsgA; Reviewed; Region: PRK01889 393127004160 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393127004161 RNA binding site [nucleotide binding]; other site 393127004162 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 393127004163 GTPase/Zn-binding domain interface [polypeptide binding]; other site 393127004164 GTP/Mg2+ binding site [chemical binding]; other site 393127004165 G4 box; other site 393127004166 G5 box; other site 393127004167 G1 box; other site 393127004168 Switch I region; other site 393127004169 G2 box; other site 393127004170 G3 box; other site 393127004171 Switch II region; other site 393127004172 YceG-like family; Region: YceG; pfam02618 393127004173 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 393127004174 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 393127004175 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 393127004176 Rhomboid family; Region: Rhomboid; pfam01694 393127004177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127004178 TPR motif; other site 393127004179 TPR repeat; Region: TPR_11; pfam13414 393127004180 binding surface 393127004181 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 393127004182 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 393127004183 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127004184 nucleotide binding site [chemical binding]; other site 393127004185 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 393127004186 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 393127004187 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 393127004188 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 393127004189 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393127004190 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 393127004191 Type II/IV secretion system protein; Region: T2SE; pfam00437 393127004192 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393127004193 Walker A motif; other site 393127004194 ATP binding site [chemical binding]; other site 393127004195 Walker B motif; other site 393127004196 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 393127004197 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 393127004198 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 393127004199 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 393127004200 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393127004201 tetramer interface [polypeptide binding]; other site 393127004202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127004203 catalytic residue [active] 393127004204 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 393127004205 tetramer interface [polypeptide binding]; other site 393127004206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127004207 catalytic residue [active] 393127004208 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 393127004209 active site residue [active] 393127004210 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 393127004211 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 393127004212 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 393127004213 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 393127004214 active site 393127004215 elongation factor P; Validated; Region: PRK00529 393127004216 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 393127004217 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 393127004218 RNA binding site [nucleotide binding]; other site 393127004219 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 393127004220 RNA binding site [nucleotide binding]; other site 393127004221 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 393127004222 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 393127004223 carboxyltransferase (CT) interaction site; other site 393127004224 biotinylation site [posttranslational modification]; other site 393127004225 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 393127004226 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393127004227 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393127004228 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 393127004229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 393127004230 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 393127004231 putative RNA binding site [nucleotide binding]; other site 393127004232 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 393127004233 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 393127004234 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 393127004235 homodimer interface [polypeptide binding]; other site 393127004236 NADP binding site [chemical binding]; other site 393127004237 substrate binding site [chemical binding]; other site 393127004238 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 393127004239 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 393127004240 generic binding surface II; other site 393127004241 generic binding surface I; other site 393127004242 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 393127004243 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393127004244 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393127004245 substrate binding pocket [chemical binding]; other site 393127004246 chain length determination region; other site 393127004247 substrate-Mg2+ binding site; other site 393127004248 catalytic residues [active] 393127004249 aspartate-rich region 1; other site 393127004250 active site lid residues [active] 393127004251 aspartate-rich region 2; other site 393127004252 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393127004253 DNA-binding site [nucleotide binding]; DNA binding site 393127004254 RNA-binding motif; other site 393127004255 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 393127004256 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 393127004257 TPP-binding site; other site 393127004258 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393127004259 PYR/PP interface [polypeptide binding]; other site 393127004260 dimer interface [polypeptide binding]; other site 393127004261 TPP binding site [chemical binding]; other site 393127004262 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127004263 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 393127004264 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127004265 RNA binding surface [nucleotide binding]; other site 393127004266 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 393127004267 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 393127004268 arginine repressor; Provisional; Region: PRK04280 393127004269 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 393127004270 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 393127004271 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393127004272 Walker A/P-loop; other site 393127004273 ATP binding site [chemical binding]; other site 393127004274 Q-loop/lid; other site 393127004275 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 393127004276 ABC transporter signature motif; other site 393127004277 Walker B; other site 393127004278 D-loop; other site 393127004279 H-loop/switch region; other site 393127004280 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 393127004281 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127004282 nucleotide binding site [chemical binding]; other site 393127004283 Acetokinase family; Region: Acetate_kinase; cl17229 393127004284 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 393127004285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127004286 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393127004287 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 393127004288 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 393127004289 tetramer interface [polypeptide binding]; other site 393127004290 TPP-binding site [chemical binding]; other site 393127004291 heterodimer interface [polypeptide binding]; other site 393127004292 phosphorylation loop region [posttranslational modification] 393127004293 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 393127004294 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 393127004295 alpha subunit interface [polypeptide binding]; other site 393127004296 TPP binding site [chemical binding]; other site 393127004297 heterodimer interface [polypeptide binding]; other site 393127004298 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 393127004299 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 393127004300 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 393127004301 E3 interaction surface; other site 393127004302 lipoyl attachment site [posttranslational modification]; other site 393127004303 e3 binding domain; Region: E3_binding; pfam02817 393127004304 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 393127004305 peptidase T-like protein; Region: PepT-like; TIGR01883 393127004306 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 393127004307 metal binding site [ion binding]; metal-binding site 393127004308 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 393127004309 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 393127004310 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 393127004311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127004312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127004313 active site 393127004314 phosphorylation site [posttranslational modification] 393127004315 intermolecular recognition site; other site 393127004316 dimerization interface [polypeptide binding]; other site 393127004317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127004318 DNA binding site [nucleotide binding] 393127004319 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 393127004320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127004321 dimerization interface [polypeptide binding]; other site 393127004322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127004323 dimer interface [polypeptide binding]; other site 393127004324 phosphorylation site [posttranslational modification] 393127004325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127004326 Mg2+ binding site [ion binding]; other site 393127004327 G-X-G motif; other site 393127004328 OxaA-like protein precursor; Validated; Region: PRK01622 393127004329 acylphosphatase; Provisional; Region: PRK14443 393127004330 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 393127004331 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 393127004332 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 393127004333 homotetramer interface [polypeptide binding]; other site 393127004334 FMN binding site [chemical binding]; other site 393127004335 homodimer contacts [polypeptide binding]; other site 393127004336 putative active site [active] 393127004337 putative substrate binding site [chemical binding]; other site 393127004338 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 393127004339 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 393127004340 active site residue [active] 393127004341 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 393127004342 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393127004343 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127004344 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127004345 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 393127004346 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 393127004347 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393127004348 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 393127004349 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 393127004350 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 393127004351 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 393127004352 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 393127004353 ligand binding site [chemical binding]; other site 393127004354 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 393127004355 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 393127004356 Walker A/P-loop; other site 393127004357 ATP binding site [chemical binding]; other site 393127004358 Q-loop/lid; other site 393127004359 ABC transporter signature motif; other site 393127004360 Walker B; other site 393127004361 D-loop; other site 393127004362 H-loop/switch region; other site 393127004363 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 393127004364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 393127004365 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 393127004366 TM-ABC transporter signature motif; other site 393127004367 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 393127004368 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 393127004369 TM-ABC transporter signature motif; other site 393127004370 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393127004371 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393127004372 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 393127004373 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 393127004374 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 393127004375 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 393127004376 classical (c) SDRs; Region: SDR_c; cd05233 393127004377 NAD(P) binding site [chemical binding]; other site 393127004378 active site 393127004379 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 393127004380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127004381 non-specific DNA binding site [nucleotide binding]; other site 393127004382 salt bridge; other site 393127004383 sequence-specific DNA binding site [nucleotide binding]; other site 393127004384 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 393127004385 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 393127004386 competence damage-inducible protein A; Provisional; Region: PRK00549 393127004387 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 393127004388 putative MPT binding site; other site 393127004389 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 393127004390 recombinase A; Provisional; Region: recA; PRK09354 393127004391 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 393127004392 hexamer interface [polypeptide binding]; other site 393127004393 Walker A motif; other site 393127004394 ATP binding site [chemical binding]; other site 393127004395 Walker B motif; other site 393127004396 phosphodiesterase; Provisional; Region: PRK12704 393127004397 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127004398 Zn2+ binding site [ion binding]; other site 393127004399 Mg2+ binding site [ion binding]; other site 393127004400 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 393127004401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127004402 Coenzyme A binding pocket [chemical binding]; other site 393127004403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393127004404 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 393127004405 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393127004406 putative active site [active] 393127004407 metal binding site [ion binding]; metal-binding site 393127004408 homodimer binding site [polypeptide binding]; other site 393127004409 Predicted membrane protein [Function unknown]; Region: COG4550 393127004410 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 393127004411 MutS domain I; Region: MutS_I; pfam01624 393127004412 MutS domain II; Region: MutS_II; pfam05188 393127004413 MutS domain III; Region: MutS_III; pfam05192 393127004414 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 393127004415 Walker A/P-loop; other site 393127004416 ATP binding site [chemical binding]; other site 393127004417 Q-loop/lid; other site 393127004418 ABC transporter signature motif; other site 393127004419 Walker B; other site 393127004420 D-loop; other site 393127004421 H-loop/switch region; other site 393127004422 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 393127004423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127004424 ATP binding site [chemical binding]; other site 393127004425 Mg2+ binding site [ion binding]; other site 393127004426 G-X-G motif; other site 393127004427 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 393127004428 ATP binding site [chemical binding]; other site 393127004429 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 393127004430 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 393127004431 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 393127004432 Pyruvate formate lyase 1; Region: PFL1; cd01678 393127004433 coenzyme A binding site [chemical binding]; other site 393127004434 active site 393127004435 catalytic residues [active] 393127004436 glycine loop; other site 393127004437 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 393127004438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393127004439 FeS/SAM binding site; other site 393127004440 Predicted transcriptional regulators [Transcription]; Region: COG1695 393127004441 Transcriptional regulator PadR-like family; Region: PadR; cl17335 393127004442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127004443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127004444 putative substrate translocation pore; other site 393127004445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127004446 non-specific DNA binding site [nucleotide binding]; other site 393127004447 salt bridge; other site 393127004448 sequence-specific DNA binding site [nucleotide binding]; other site 393127004449 topology modulation protein; Provisional; Region: PRK07261 393127004450 AAA domain; Region: AAA_17; pfam13207 393127004451 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127004452 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127004453 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127004454 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127004455 putative acyltransferase; Provisional; Region: PRK05790 393127004456 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 393127004457 dimer interface [polypeptide binding]; other site 393127004458 active site 393127004459 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 393127004460 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 393127004461 dimer interface [polypeptide binding]; other site 393127004462 active site 393127004463 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393127004464 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 393127004465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127004466 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 393127004467 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 393127004468 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 393127004469 Domain of unknown function DUF20; Region: UPF0118; pfam01594 393127004470 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 393127004471 FAD binding domain; Region: FAD_binding_4; pfam01565 393127004472 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 393127004473 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 393127004474 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 393127004475 Walker A/P-loop; other site 393127004476 ATP binding site [chemical binding]; other site 393127004477 Q-loop/lid; other site 393127004478 ABC transporter signature motif; other site 393127004479 Walker B; other site 393127004480 D-loop; other site 393127004481 H-loop/switch region; other site 393127004482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393127004483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127004484 dimer interface [polypeptide binding]; other site 393127004485 conserved gate region; other site 393127004486 ABC-ATPase subunit interface; other site 393127004487 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 393127004488 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 393127004489 manganese transport protein MntH; Reviewed; Region: PRK00701 393127004490 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 393127004491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127004492 dimer interface [polypeptide binding]; other site 393127004493 conserved gate region; other site 393127004494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 393127004495 ABC-ATPase subunit interface; other site 393127004496 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 393127004497 LysR substrate binding domain; Region: LysR_substrate; pfam03466 393127004498 dimerization interface [polypeptide binding]; other site 393127004499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127004500 dimer interface [polypeptide binding]; other site 393127004501 conserved gate region; other site 393127004502 putative PBP binding loops; other site 393127004503 ABC-ATPase subunit interface; other site 393127004504 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 393127004505 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 393127004506 Walker A/P-loop; other site 393127004507 ATP binding site [chemical binding]; other site 393127004508 Q-loop/lid; other site 393127004509 ABC transporter signature motif; other site 393127004510 Walker B; other site 393127004511 D-loop; other site 393127004512 H-loop/switch region; other site 393127004513 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 393127004514 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 393127004515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 393127004516 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 393127004517 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127004518 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127004519 ABC transporter; Region: ABC_tran_2; pfam12848 393127004520 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127004521 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 393127004522 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127004523 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127004524 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 393127004525 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 393127004526 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127004527 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 393127004528 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 393127004529 dihydrodipicolinate synthase; Region: dapA; TIGR00674 393127004530 dimer interface [polypeptide binding]; other site 393127004531 active site 393127004532 catalytic residue [active] 393127004533 aspartate kinase I; Reviewed; Region: PRK08210 393127004534 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 393127004535 nucleotide binding site [chemical binding]; other site 393127004536 substrate binding site [chemical binding]; other site 393127004537 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 393127004538 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 393127004539 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 393127004540 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 393127004541 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 393127004542 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393127004543 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393127004544 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 393127004545 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 393127004546 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 393127004547 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 393127004548 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 393127004549 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393127004550 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 393127004551 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 393127004552 Predicted membrane protein [Function unknown]; Region: COG4392 393127004553 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 393127004554 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 393127004555 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393127004556 metal binding site 2 [ion binding]; metal-binding site 393127004557 putative DNA binding helix; other site 393127004558 metal binding site 1 [ion binding]; metal-binding site 393127004559 dimer interface [polypeptide binding]; other site 393127004560 structural Zn2+ binding site [ion binding]; other site 393127004561 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393127004562 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127004563 ABC-ATPase subunit interface; other site 393127004564 dimer interface [polypeptide binding]; other site 393127004565 putative PBP binding regions; other site 393127004566 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 393127004567 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393127004568 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 393127004569 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 393127004570 DHHA2 domain; Region: DHHA2; pfam02833 393127004571 endonuclease IV; Provisional; Region: PRK01060 393127004572 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 393127004573 AP (apurinic/apyrimidinic) site pocket; other site 393127004574 DNA interaction; other site 393127004575 Metal-binding active site; metal-binding site 393127004576 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 393127004577 DEAD-like helicases superfamily; Region: DEXDc; smart00487 393127004578 ATP binding site [chemical binding]; other site 393127004579 Mg++ binding site [ion binding]; other site 393127004580 motif III; other site 393127004581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127004582 nucleotide binding region [chemical binding]; other site 393127004583 ATP-binding site [chemical binding]; other site 393127004584 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 393127004585 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 393127004586 Uncharacterized conserved protein [Function unknown]; Region: COG0327 393127004587 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 393127004588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 393127004589 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 393127004590 Uncharacterized conserved protein [Function unknown]; Region: COG0327 393127004591 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 393127004592 Family of unknown function (DUF633); Region: DUF633; pfam04816 393127004593 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 393127004594 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 393127004595 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 393127004596 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 393127004597 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 393127004598 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 393127004599 DNA binding residues [nucleotide binding] 393127004600 DNA primase; Validated; Region: dnaG; PRK05667 393127004601 CHC2 zinc finger; Region: zf-CHC2; pfam01807 393127004602 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 393127004603 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 393127004604 active site 393127004605 metal binding site [ion binding]; metal-binding site 393127004606 interdomain interaction site; other site 393127004607 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 393127004608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 393127004609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 393127004610 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 393127004611 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 393127004612 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 393127004613 dimer interface [polypeptide binding]; other site 393127004614 motif 1; other site 393127004615 active site 393127004616 motif 2; other site 393127004617 motif 3; other site 393127004618 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 393127004619 Recombination protein O N terminal; Region: RecO_N; pfam11967 393127004620 Recombination protein O C terminal; Region: RecO_C; pfam02565 393127004621 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 393127004622 GTPase Era; Reviewed; Region: era; PRK00089 393127004623 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 393127004624 G1 box; other site 393127004625 GTP/Mg2+ binding site [chemical binding]; other site 393127004626 Switch I region; other site 393127004627 G2 box; other site 393127004628 Switch II region; other site 393127004629 G3 box; other site 393127004630 G4 box; other site 393127004631 G5 box; other site 393127004632 KH domain; Region: KH_2; pfam07650 393127004633 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 393127004634 active site 393127004635 catalytic motif [active] 393127004636 Zn binding site [ion binding]; other site 393127004637 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 393127004638 metal-binding heat shock protein; Provisional; Region: PRK00016 393127004639 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 393127004640 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 393127004641 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127004642 Zn2+ binding site [ion binding]; other site 393127004643 Mg2+ binding site [ion binding]; other site 393127004644 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 393127004645 PhoH-like protein; Region: PhoH; pfam02562 393127004646 Yqey-like protein; Region: YqeY; pfam09424 393127004647 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 393127004648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 393127004649 RNA methyltransferase, RsmE family; Region: TIGR00046 393127004650 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 393127004651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127004652 S-adenosylmethionine binding site [chemical binding]; other site 393127004653 chaperone protein DnaJ; Provisional; Region: PRK14280 393127004654 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 393127004655 HSP70 interaction site [polypeptide binding]; other site 393127004656 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 393127004657 substrate binding site [polypeptide binding]; other site 393127004658 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 393127004659 Zn binding sites [ion binding]; other site 393127004660 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 393127004661 dimer interface [polypeptide binding]; other site 393127004662 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 393127004663 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 393127004664 nucleotide binding site [chemical binding]; other site 393127004665 NEF interaction site [polypeptide binding]; other site 393127004666 SBD interface [polypeptide binding]; other site 393127004667 heat shock protein GrpE; Provisional; Region: PRK14140 393127004668 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 393127004669 dimer interface [polypeptide binding]; other site 393127004670 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 393127004671 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 393127004672 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 393127004673 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 393127004674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 393127004675 FeS/SAM binding site; other site 393127004676 HemN C-terminal domain; Region: HemN_C; pfam06969 393127004677 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 393127004678 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 393127004679 NADP binding site [chemical binding]; other site 393127004680 putative substrate binding site [chemical binding]; other site 393127004681 active site 393127004682 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127004683 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393127004684 DNA binding residues [nucleotide binding] 393127004685 putative dimer interface [polypeptide binding]; other site 393127004686 GTP-binding protein LepA; Provisional; Region: PRK05433 393127004687 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 393127004688 G1 box; other site 393127004689 putative GEF interaction site [polypeptide binding]; other site 393127004690 GTP/Mg2+ binding site [chemical binding]; other site 393127004691 Switch I region; other site 393127004692 G2 box; other site 393127004693 G3 box; other site 393127004694 Switch II region; other site 393127004695 G4 box; other site 393127004696 G5 box; other site 393127004697 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 393127004698 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 393127004699 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 393127004700 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 393127004701 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 393127004702 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 393127004703 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 393127004704 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 393127004705 Competence protein; Region: Competence; pfam03772 393127004706 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127004707 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 393127004708 catalytic motif [active] 393127004709 Zn binding site [ion binding]; other site 393127004710 SLBB domain; Region: SLBB; pfam10531 393127004711 comEA protein; Region: comE; TIGR01259 393127004712 Helix-hairpin-helix motif; Region: HHH; pfam00633 393127004713 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393127004714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127004715 S-adenosylmethionine binding site [chemical binding]; other site 393127004716 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 393127004717 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127004718 Zn2+ binding site [ion binding]; other site 393127004719 Mg2+ binding site [ion binding]; other site 393127004720 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 393127004721 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 393127004722 active site 393127004723 (T/H)XGH motif; other site 393127004724 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 393127004725 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 393127004726 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393127004727 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393127004728 shikimate binding site; other site 393127004729 NAD(P) binding site [chemical binding]; other site 393127004730 GTPase YqeH; Provisional; Region: PRK13796 393127004731 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 393127004732 GTP/Mg2+ binding site [chemical binding]; other site 393127004733 G4 box; other site 393127004734 G5 box; other site 393127004735 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 393127004736 G1 box; other site 393127004737 G1 box; other site 393127004738 GTP/Mg2+ binding site [chemical binding]; other site 393127004739 G2 box; other site 393127004740 Switch I region; other site 393127004741 G2 box; other site 393127004742 Switch I region; other site 393127004743 G3 box; other site 393127004744 G3 box; other site 393127004745 Switch II region; other site 393127004746 Switch II region; other site 393127004747 G4 box; other site 393127004748 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 393127004749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127004750 motif II; other site 393127004751 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 393127004752 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 393127004753 active site 393127004754 Zn binding site [ion binding]; other site 393127004755 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 393127004756 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 393127004757 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 393127004758 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 393127004759 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 393127004760 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 393127004761 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 393127004762 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 393127004763 Sugar specificity; other site 393127004764 Pyrimidine base specificity; other site 393127004765 ATP-binding site [chemical binding]; other site 393127004766 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 393127004767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127004768 S-adenosylmethionine binding site [chemical binding]; other site 393127004769 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 393127004770 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 393127004771 dimerization interface [polypeptide binding]; other site 393127004772 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393127004773 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393127004774 hypothetical protein; Provisional; Region: PRK13678 393127004775 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 393127004776 hypothetical protein; Provisional; Region: PRK05473 393127004777 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 393127004778 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 393127004779 motif 1; other site 393127004780 active site 393127004781 motif 2; other site 393127004782 motif 3; other site 393127004783 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393127004784 DHHA1 domain; Region: DHHA1; pfam02272 393127004785 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127004786 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127004787 Walker A/P-loop; other site 393127004788 ATP binding site [chemical binding]; other site 393127004789 Q-loop/lid; other site 393127004790 ABC transporter signature motif; other site 393127004791 Walker B; other site 393127004792 D-loop; other site 393127004793 H-loop/switch region; other site 393127004794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127004795 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127004796 FtsX-like permease family; Region: FtsX; pfam02687 393127004797 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127004798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127004799 active site 393127004800 phosphorylation site [posttranslational modification] 393127004801 intermolecular recognition site; other site 393127004802 dimerization interface [polypeptide binding]; other site 393127004803 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127004804 DNA binding site [nucleotide binding] 393127004805 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 393127004806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127004807 dimerization interface [polypeptide binding]; other site 393127004808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127004809 dimer interface [polypeptide binding]; other site 393127004810 phosphorylation site [posttranslational modification] 393127004811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127004812 ATP binding site [chemical binding]; other site 393127004813 Mg2+ binding site [ion binding]; other site 393127004814 G-X-G motif; other site 393127004815 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 393127004816 AAA domain; Region: AAA_30; pfam13604 393127004817 Family description; Region: UvrD_C_2; pfam13538 393127004818 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127004819 binding surface 393127004820 TPR motif; other site 393127004821 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 393127004822 TPR repeat; Region: TPR_11; pfam13414 393127004823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127004824 binding surface 393127004825 TPR motif; other site 393127004826 TPR repeat; Region: TPR_11; pfam13414 393127004827 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 393127004828 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 393127004829 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 393127004830 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393127004831 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393127004832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127004833 catalytic residue [active] 393127004834 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 393127004835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127004836 Walker A motif; other site 393127004837 ATP binding site [chemical binding]; other site 393127004838 Walker B motif; other site 393127004839 arginine finger; other site 393127004840 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 393127004841 Predicted transcriptional regulator [Transcription]; Region: COG1959 393127004842 Transcriptional regulator; Region: Rrf2; pfam02082 393127004843 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 393127004844 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 393127004845 Nitrogen regulatory protein P-II; Region: P-II; smart00938 393127004846 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 393127004847 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 393127004848 anticodon binding site; other site 393127004849 Dimer interface [polypeptide binding]; other site 393127004850 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 393127004851 homodimer interface [polypeptide binding]; other site 393127004852 motif 1; other site 393127004853 active site 393127004854 motif 2; other site 393127004855 GAD domain; Region: GAD; pfam02938 393127004856 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 393127004857 motif 3; other site 393127004858 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 393127004859 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 393127004860 dimer interface [polypeptide binding]; other site 393127004861 motif 1; other site 393127004862 active site 393127004863 motif 2; other site 393127004864 motif 3; other site 393127004865 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 393127004866 anticodon binding site; other site 393127004867 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 393127004868 Bacterial SH3 domain; Region: SH3_3; pfam08239 393127004869 Bacterial SH3 domain; Region: SH3_3; pfam08239 393127004870 Bacterial SH3 domain homologues; Region: SH3b; smart00287 393127004871 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 393127004872 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 393127004873 active site 393127004874 metal binding site [ion binding]; metal-binding site 393127004875 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 393127004876 putative active site [active] 393127004877 dimerization interface [polypeptide binding]; other site 393127004878 putative tRNAtyr binding site [nucleotide binding]; other site 393127004879 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 393127004880 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127004881 Zn2+ binding site [ion binding]; other site 393127004882 Mg2+ binding site [ion binding]; other site 393127004883 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 393127004884 synthetase active site [active] 393127004885 NTP binding site [chemical binding]; other site 393127004886 metal binding site [ion binding]; metal-binding site 393127004887 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 393127004888 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 393127004889 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127004890 active site 393127004891 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 393127004892 DHH family; Region: DHH; pfam01368 393127004893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 393127004894 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 393127004895 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 393127004896 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 393127004897 Protein export membrane protein; Region: SecD_SecF; cl14618 393127004898 Protein export membrane protein; Region: SecD_SecF; pfam02355 393127004899 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 393127004900 Preprotein translocase subunit; Region: YajC; pfam02699 393127004901 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 393127004902 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 393127004903 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 393127004904 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 393127004905 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 393127004906 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127004907 Walker A motif; other site 393127004908 ATP binding site [chemical binding]; other site 393127004909 Walker B motif; other site 393127004910 arginine finger; other site 393127004911 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 393127004912 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 393127004913 RuvA N terminal domain; Region: RuvA_N; pfam01330 393127004914 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 393127004915 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393127004916 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127004917 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 393127004918 NAD binding site [chemical binding]; other site 393127004919 dimer interface [polypeptide binding]; other site 393127004920 substrate binding site [chemical binding]; other site 393127004921 hypothetical protein; Validated; Region: PRK00110 393127004922 prephenate dehydratase; Provisional; Region: PRK11898 393127004923 Prephenate dehydratase; Region: PDT; pfam00800 393127004924 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 393127004925 putative L-Phe binding site [chemical binding]; other site 393127004926 GTPase CgtA; Reviewed; Region: obgE; PRK12297 393127004927 GTP1/OBG; Region: GTP1_OBG; pfam01018 393127004928 Obg GTPase; Region: Obg; cd01898 393127004929 G1 box; other site 393127004930 GTP/Mg2+ binding site [chemical binding]; other site 393127004931 Switch I region; other site 393127004932 G2 box; other site 393127004933 G3 box; other site 393127004934 Switch II region; other site 393127004935 G4 box; other site 393127004936 G5 box; other site 393127004937 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 393127004938 glycerol kinase; Provisional; Region: glpK; PRK00047 393127004939 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 393127004940 N- and C-terminal domain interface [polypeptide binding]; other site 393127004941 active site 393127004942 MgATP binding site [chemical binding]; other site 393127004943 catalytic site [active] 393127004944 metal binding site [ion binding]; metal-binding site 393127004945 glycerol binding site [chemical binding]; other site 393127004946 homotetramer interface [polypeptide binding]; other site 393127004947 homodimer interface [polypeptide binding]; other site 393127004948 FBP binding site [chemical binding]; other site 393127004949 protein IIAGlc interface [polypeptide binding]; other site 393127004950 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 393127004951 amphipathic channel; other site 393127004952 Asn-Pro-Ala signature motifs; other site 393127004953 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 393127004954 hypothetical protein; Provisional; Region: PRK14553 393127004955 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 393127004956 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 393127004957 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 393127004958 homodimer interface [polypeptide binding]; other site 393127004959 oligonucleotide binding site [chemical binding]; other site 393127004960 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 393127004961 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 393127004962 Switch I; other site 393127004963 Switch II; other site 393127004964 septum formation inhibitor; Reviewed; Region: minC; PRK00513 393127004965 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 393127004966 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 393127004967 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 393127004968 Protein of unknown function (DUF972); Region: DUF972; pfam06156 393127004969 rod shape-determining protein MreC; Region: MreC; pfam04085 393127004970 rod shape-determining protein MreB; Provisional; Region: PRK13927 393127004971 MreB and similar proteins; Region: MreB_like; cd10225 393127004972 nucleotide binding site [chemical binding]; other site 393127004973 Mg binding site [ion binding]; other site 393127004974 putative protofilament interaction site [polypeptide binding]; other site 393127004975 RodZ interaction site [polypeptide binding]; other site 393127004976 hypothetical protein; Reviewed; Region: PRK00024 393127004977 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 393127004978 MPN+ (JAMM) motif; other site 393127004979 Zinc-binding site [ion binding]; other site 393127004980 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 393127004981 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 393127004982 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 393127004983 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393127004984 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393127004985 AAA domain; Region: AAA_14; pfam13173 393127004986 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 393127004987 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 393127004988 active site 393127004989 HIGH motif; other site 393127004990 nucleotide binding site [chemical binding]; other site 393127004991 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393127004992 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 393127004993 active site 393127004994 KMSKS motif; other site 393127004995 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 393127004996 tRNA binding surface [nucleotide binding]; other site 393127004997 anticodon binding site; other site 393127004998 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 393127004999 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 393127005000 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393127005001 inhibitor-cofactor binding pocket; inhibition site 393127005002 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005003 catalytic residue [active] 393127005004 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 393127005005 dimer interface [polypeptide binding]; other site 393127005006 active site 393127005007 Schiff base residues; other site 393127005008 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 393127005009 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 393127005010 active site 393127005011 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 393127005012 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 393127005013 domain interfaces; other site 393127005014 active site 393127005015 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 393127005016 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 393127005017 tRNA; other site 393127005018 putative tRNA binding site [nucleotide binding]; other site 393127005019 putative NADP binding site [chemical binding]; other site 393127005020 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 393127005021 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 393127005022 G1 box; other site 393127005023 GTP/Mg2+ binding site [chemical binding]; other site 393127005024 Switch I region; other site 393127005025 G2 box; other site 393127005026 G3 box; other site 393127005027 Switch II region; other site 393127005028 G4 box; other site 393127005029 G5 box; other site 393127005030 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 393127005031 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 393127005032 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 393127005033 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 393127005034 active site 393127005035 dimer interface [polypeptide binding]; other site 393127005036 motif 1; other site 393127005037 motif 2; other site 393127005038 motif 3; other site 393127005039 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 393127005040 anticodon binding site; other site 393127005041 primosomal protein DnaI; Reviewed; Region: PRK08939 393127005042 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 393127005043 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 393127005044 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 393127005045 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 393127005046 ATP cone domain; Region: ATP-cone; pfam03477 393127005047 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 393127005048 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 393127005049 CoA-binding site [chemical binding]; other site 393127005050 ATP-binding [chemical binding]; other site 393127005051 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 393127005052 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 393127005053 DNA binding site [nucleotide binding] 393127005054 catalytic residue [active] 393127005055 H2TH interface [polypeptide binding]; other site 393127005056 putative catalytic residues [active] 393127005057 turnover-facilitating residue; other site 393127005058 intercalation triad [nucleotide binding]; other site 393127005059 8OG recognition residue [nucleotide binding]; other site 393127005060 putative reading head residues; other site 393127005061 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 393127005062 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393127005063 DNA polymerase I; Provisional; Region: PRK05755 393127005064 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 393127005065 active site 393127005066 metal binding site 1 [ion binding]; metal-binding site 393127005067 putative 5' ssDNA interaction site; other site 393127005068 metal binding site 3; metal-binding site 393127005069 metal binding site 2 [ion binding]; metal-binding site 393127005070 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 393127005071 putative DNA binding site [nucleotide binding]; other site 393127005072 putative metal binding site [ion binding]; other site 393127005073 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 393127005074 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 393127005075 active site 393127005076 DNA binding site [nucleotide binding] 393127005077 catalytic site [active] 393127005078 isocitrate dehydrogenase; Reviewed; Region: PRK07006 393127005079 isocitrate dehydrogenase; Validated; Region: PRK07362 393127005080 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 393127005081 dimer interface [polypeptide binding]; other site 393127005082 Citrate synthase; Region: Citrate_synt; pfam00285 393127005083 active site 393127005084 citrylCoA binding site [chemical binding]; other site 393127005085 oxalacetate/citrate binding site [chemical binding]; other site 393127005086 coenzyme A binding site [chemical binding]; other site 393127005087 catalytic triad [active] 393127005088 Protein of unknown function (DUF441); Region: DUF441; pfam04284 393127005089 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 393127005090 pyruvate kinase; Provisional; Region: PRK06354 393127005091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 393127005092 active site 393127005093 domain interfaces; other site 393127005094 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 393127005095 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 393127005096 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 393127005097 active site 393127005098 ADP/pyrophosphate binding site [chemical binding]; other site 393127005099 dimerization interface [polypeptide binding]; other site 393127005100 allosteric effector site; other site 393127005101 fructose-1,6-bisphosphate binding site; other site 393127005102 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 393127005103 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 393127005104 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 393127005105 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 393127005106 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 393127005107 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 393127005108 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 393127005109 active site 393127005110 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 393127005111 generic binding surface I; other site 393127005112 generic binding surface II; other site 393127005113 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 393127005114 DHH family; Region: DHH; pfam01368 393127005115 DHHA1 domain; Region: DHHA1; pfam02272 393127005116 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 393127005117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 393127005118 DNA-binding site [nucleotide binding]; DNA binding site 393127005119 DRTGG domain; Region: DRTGG; pfam07085 393127005120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 393127005121 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 393127005122 active site 2 [active] 393127005123 active site 1 [active] 393127005124 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 393127005125 metal-dependent hydrolase; Provisional; Region: PRK00685 393127005126 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 393127005127 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 393127005128 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 393127005129 active site 393127005130 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 393127005131 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 393127005132 hexamer interface [polypeptide binding]; other site 393127005133 ligand binding site [chemical binding]; other site 393127005134 putative active site [active] 393127005135 NAD(P) binding site [chemical binding]; other site 393127005136 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393127005137 Ligand Binding Site [chemical binding]; other site 393127005138 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 393127005139 propionate/acetate kinase; Provisional; Region: PRK12379 393127005140 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 393127005141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005142 S-adenosylmethionine binding site [chemical binding]; other site 393127005143 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 393127005144 dimer interface [polypeptide binding]; other site 393127005145 catalytic triad [active] 393127005146 peroxidatic and resolving cysteines [active] 393127005147 RDD family; Region: RDD; pfam06271 393127005148 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 393127005149 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 393127005150 tandem repeat interface [polypeptide binding]; other site 393127005151 oligomer interface [polypeptide binding]; other site 393127005152 active site residues [active] 393127005153 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 393127005154 ATP-NAD kinase; Region: NAD_kinase; pfam01513 393127005155 ornithine carbamoyltransferase; Provisional; Region: PRK00779 393127005156 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393127005157 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393127005158 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 393127005159 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393127005160 inhibitor-cofactor binding pocket; inhibition site 393127005161 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005162 catalytic residue [active] 393127005163 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 393127005164 nucleotide binding site [chemical binding]; other site 393127005165 N-acetyl-L-glutamate binding site [chemical binding]; other site 393127005166 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 393127005167 heterotetramer interface [polypeptide binding]; other site 393127005168 active site pocket [active] 393127005169 cleavage site 393127005170 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 393127005171 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 393127005172 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 393127005173 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 393127005174 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 393127005175 Ligand Binding Site [chemical binding]; other site 393127005176 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393127005177 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393127005178 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127005179 catalytic residue [active] 393127005180 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 393127005181 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 393127005182 GAF domain; Region: GAF_2; pfam13185 393127005183 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 393127005184 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 393127005185 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127005186 RNA binding surface [nucleotide binding]; other site 393127005187 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 393127005188 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 393127005189 active site 393127005190 HIGH motif; other site 393127005191 dimer interface [polypeptide binding]; other site 393127005192 KMSKS motif; other site 393127005193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127005194 RNA binding surface [nucleotide binding]; other site 393127005195 catabolite control protein A; Region: ccpA; TIGR01481 393127005196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127005197 DNA binding site [nucleotide binding] 393127005198 domain linker motif; other site 393127005199 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 393127005200 dimerization interface [polypeptide binding]; other site 393127005201 effector binding site; other site 393127005202 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 393127005203 Chorismate mutase type II; Region: CM_2; cl00693 393127005204 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 393127005205 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 393127005206 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 393127005207 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 393127005208 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 393127005209 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 393127005210 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 393127005211 dimer interface [polypeptide binding]; other site 393127005212 decamer (pentamer of dimers) interface [polypeptide binding]; other site 393127005213 catalytic triad [active] 393127005214 peroxidatic and resolving cysteines [active] 393127005215 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 393127005216 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393127005217 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393127005218 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393127005219 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 393127005220 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 393127005221 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 393127005222 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 393127005223 putative tRNA-binding site [nucleotide binding]; other site 393127005224 hypothetical protein; Provisional; Region: PRK13668 393127005225 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127005226 catalytic residues [active] 393127005227 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 393127005228 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 393127005229 oligomer interface [polypeptide binding]; other site 393127005230 active site 393127005231 metal binding site [ion binding]; metal-binding site 393127005232 Predicted small secreted protein [Function unknown]; Region: COG5584 393127005233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 393127005234 putative homodimer interface [polypeptide binding]; other site 393127005235 putative homotetramer interface [polypeptide binding]; other site 393127005236 putative allosteric switch controlling residues; other site 393127005237 putative metal binding site [ion binding]; other site 393127005238 putative homodimer-homodimer interface [polypeptide binding]; other site 393127005239 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127005240 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005241 S-adenosylmethionine binding site [chemical binding]; other site 393127005242 Phosphotransferase enzyme family; Region: APH; pfam01636 393127005243 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 393127005244 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 393127005245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127005246 putative substrate translocation pore; other site 393127005247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127005248 MarR family; Region: MarR; pfam01047 393127005249 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 393127005250 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393127005251 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 393127005252 homodimer interface [polypeptide binding]; other site 393127005253 substrate-cofactor binding pocket; other site 393127005254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005255 catalytic residue [active] 393127005256 dipeptidase PepV; Reviewed; Region: PRK07318 393127005257 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 393127005258 active site 393127005259 metal binding site [ion binding]; metal-binding site 393127005260 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 393127005261 nudix motif; other site 393127005262 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 393127005263 putative substrate binding site [chemical binding]; other site 393127005264 putative ATP binding site [chemical binding]; other site 393127005265 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 393127005266 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 393127005267 active site 393127005268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393127005269 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393127005270 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 393127005271 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 393127005272 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 393127005273 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 393127005274 substrate binding site [chemical binding]; other site 393127005275 active site 393127005276 catalytic residues [active] 393127005277 heterodimer interface [polypeptide binding]; other site 393127005278 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 393127005279 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 393127005280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005281 catalytic residue [active] 393127005282 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 393127005283 active site 393127005284 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 393127005285 active site 393127005286 ribulose/triose binding site [chemical binding]; other site 393127005287 phosphate binding site [ion binding]; other site 393127005288 substrate (anthranilate) binding pocket [chemical binding]; other site 393127005289 product (indole) binding pocket [chemical binding]; other site 393127005290 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 393127005291 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 393127005292 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 393127005293 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393127005294 Glutamine amidotransferase class-I; Region: GATase; pfam00117 393127005295 glutamine binding [chemical binding]; other site 393127005296 catalytic triad [active] 393127005297 anthranilate synthase component I; Provisional; Region: PRK13570 393127005298 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 393127005299 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 393127005300 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 393127005301 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 393127005302 putative catalytic cysteine [active] 393127005303 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 393127005304 putative active site [active] 393127005305 metal binding site [ion binding]; metal-binding site 393127005306 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 393127005307 dimer interface [polypeptide binding]; other site 393127005308 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127005309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127005310 Walker A/P-loop; other site 393127005311 ATP binding site [chemical binding]; other site 393127005312 Q-loop/lid; other site 393127005313 ABC transporter signature motif; other site 393127005314 Walker B; other site 393127005315 D-loop; other site 393127005316 H-loop/switch region; other site 393127005317 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393127005318 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 393127005319 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 393127005320 putative dimer interface [polypeptide binding]; other site 393127005321 catalytic triad [active] 393127005322 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 393127005323 aconitate hydratase; Validated; Region: PRK09277 393127005324 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 393127005325 substrate binding site [chemical binding]; other site 393127005326 ligand binding site [chemical binding]; other site 393127005327 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 393127005328 substrate binding site [chemical binding]; other site 393127005329 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127005330 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 393127005331 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 393127005332 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127005333 ATP binding site [chemical binding]; other site 393127005334 putative Mg++ binding site [ion binding]; other site 393127005335 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127005336 nucleotide binding region [chemical binding]; other site 393127005337 ATP-binding site [chemical binding]; other site 393127005338 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 393127005339 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 393127005340 Walker A/P-loop; other site 393127005341 ATP binding site [chemical binding]; other site 393127005342 Q-loop/lid; other site 393127005343 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 393127005344 ABC transporter signature motif; other site 393127005345 Walker B; other site 393127005346 D-loop; other site 393127005347 H-loop/switch region; other site 393127005348 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 393127005349 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 393127005350 active site 393127005351 metal binding site [ion binding]; metal-binding site 393127005352 DNA binding site [nucleotide binding] 393127005353 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 393127005354 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 393127005355 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 393127005356 putative acyl-acceptor binding pocket; other site 393127005357 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 393127005358 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 393127005359 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127005360 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127005361 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 393127005362 Walker A/P-loop; other site 393127005363 ATP binding site [chemical binding]; other site 393127005364 Q-loop/lid; other site 393127005365 ABC transporter signature motif; other site 393127005366 Walker B; other site 393127005367 D-loop; other site 393127005368 H-loop/switch region; other site 393127005369 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127005370 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 393127005371 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127005372 Walker A/P-loop; other site 393127005373 ATP binding site [chemical binding]; other site 393127005374 Q-loop/lid; other site 393127005375 ABC transporter signature motif; other site 393127005376 Walker B; other site 393127005377 D-loop; other site 393127005378 H-loop/switch region; other site 393127005379 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 393127005380 active site 393127005381 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393127005382 elongation factor Ts; Provisional; Region: tsf; PRK09377 393127005383 UBA/TS-N domain; Region: UBA; pfam00627 393127005384 Elongation factor TS; Region: EF_TS; pfam00889 393127005385 Elongation factor TS; Region: EF_TS; pfam00889 393127005386 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 393127005387 rRNA interaction site [nucleotide binding]; other site 393127005388 S8 interaction site; other site 393127005389 putative laminin-1 binding site; other site 393127005390 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 393127005391 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393127005392 HIGH motif; other site 393127005393 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 393127005394 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 393127005395 active site 393127005396 KMSKS motif; other site 393127005397 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 393127005398 tRNA binding surface [nucleotide binding]; other site 393127005399 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 393127005400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005401 S-adenosylmethionine binding site [chemical binding]; other site 393127005402 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 393127005403 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 393127005404 active site 393127005405 dimer interface [polypeptide binding]; other site 393127005406 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 393127005407 Ligand Binding Site [chemical binding]; other site 393127005408 Molecular Tunnel; other site 393127005409 S-adenosylmethionine synthetase; Validated; Region: PRK05250 393127005410 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 393127005411 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 393127005412 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 393127005413 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393127005414 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393127005415 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 393127005416 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 393127005417 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127005418 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 393127005419 NAD binding site [chemical binding]; other site 393127005420 dimer interface [polypeptide binding]; other site 393127005421 substrate binding site [chemical binding]; other site 393127005422 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 393127005423 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 393127005424 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 393127005425 nudix motif; other site 393127005426 Uncharacterized conserved protein [Function unknown]; Region: COG0759 393127005427 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393127005428 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 393127005429 metal binding site [ion binding]; metal-binding site 393127005430 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 393127005431 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 393127005432 acyl-activating enzyme (AAE) consensus motif; other site 393127005433 putative AMP binding site [chemical binding]; other site 393127005434 putative active site [active] 393127005435 putative CoA binding site [chemical binding]; other site 393127005436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 393127005437 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 393127005438 substrate binding site [chemical binding]; other site 393127005439 oxyanion hole (OAH) forming residues; other site 393127005440 trimer interface [polypeptide binding]; other site 393127005441 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127005442 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 393127005443 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 393127005444 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 393127005445 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 393127005446 dimer interface [polypeptide binding]; other site 393127005447 tetramer interface [polypeptide binding]; other site 393127005448 PYR/PP interface [polypeptide binding]; other site 393127005449 TPP binding site [chemical binding]; other site 393127005450 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 393127005451 TPP-binding site; other site 393127005452 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 393127005453 chorismate binding enzyme; Region: Chorismate_bind; cl10555 393127005454 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 393127005455 UbiA prenyltransferase family; Region: UbiA; pfam01040 393127005456 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 393127005457 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 393127005458 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 393127005459 FAD binding site [chemical binding]; other site 393127005460 cystathionine beta-lyase; Provisional; Region: PRK08064 393127005461 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393127005462 homodimer interface [polypeptide binding]; other site 393127005463 substrate-cofactor binding pocket; other site 393127005464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005465 catalytic residue [active] 393127005466 cystathionine gamma-synthase; Reviewed; Region: PRK08247 393127005467 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 393127005468 homodimer interface [polypeptide binding]; other site 393127005469 substrate-cofactor binding pocket; other site 393127005470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005471 catalytic residue [active] 393127005472 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 393127005473 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 393127005474 THF binding site; other site 393127005475 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 393127005476 substrate binding site [chemical binding]; other site 393127005477 THF binding site; other site 393127005478 zinc-binding site [ion binding]; other site 393127005479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127005480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127005481 putative substrate translocation pore; other site 393127005482 ferric uptake regulator; Provisional; Region: fur; PRK09462 393127005483 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393127005484 metal binding site 2 [ion binding]; metal-binding site 393127005485 putative DNA binding helix; other site 393127005486 metal binding site 1 [ion binding]; metal-binding site 393127005487 dimer interface [polypeptide binding]; other site 393127005488 structural Zn2+ binding site [ion binding]; other site 393127005489 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 393127005490 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 393127005491 NAD binding site [chemical binding]; other site 393127005492 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 393127005493 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 393127005494 inhibitor-cofactor binding pocket; inhibition site 393127005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127005496 catalytic residue [active] 393127005497 Predicted membrane protein [Function unknown]; Region: COG4129 393127005498 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 393127005499 hypothetical protein; Provisional; Region: PRK13662 393127005500 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 393127005501 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 393127005502 putative NAD(P) binding site [chemical binding]; other site 393127005503 active site 393127005504 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 393127005505 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393127005506 minor groove reading motif; other site 393127005507 helix-hairpin-helix signature motif; other site 393127005508 substrate binding pocket [chemical binding]; other site 393127005509 active site 393127005510 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 393127005511 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 393127005512 DNA binding and oxoG recognition site [nucleotide binding] 393127005513 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 393127005514 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 393127005515 trimer interface [polypeptide binding]; other site 393127005516 active site 393127005517 WVELL protein; Region: WVELL; pfam14043 393127005518 recombination regulator RecX; Provisional; Region: recX; PRK14135 393127005519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393127005520 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 393127005521 NAD(P) binding site [chemical binding]; other site 393127005522 active site 393127005523 Predicted integral membrane protein [Function unknown]; Region: COG0392 393127005524 Uncharacterized conserved protein [Function unknown]; Region: COG2898 393127005525 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 393127005526 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 393127005527 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393127005528 Cation efflux family; Region: Cation_efflux; pfam01545 393127005529 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393127005530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 393127005531 PAS fold; Region: PAS_4; pfam08448 393127005532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 393127005533 putative active site [active] 393127005534 heme pocket [chemical binding]; other site 393127005535 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 393127005536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 393127005537 dimer interface [polypeptide binding]; other site 393127005538 putative CheW interface [polypeptide binding]; other site 393127005539 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 393127005540 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 393127005541 dimer interface [polypeptide binding]; other site 393127005542 active site 393127005543 Mn binding site [ion binding]; other site 393127005544 TRAM domain; Region: TRAM; cl01282 393127005545 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 393127005546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005547 S-adenosylmethionine binding site [chemical binding]; other site 393127005548 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 393127005549 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 393127005550 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 393127005551 Substrate-binding site [chemical binding]; other site 393127005552 Substrate specificity [chemical binding]; other site 393127005553 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 393127005554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 393127005555 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 393127005556 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 393127005557 active site 393127005558 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 393127005559 flavodoxin, short chain; Region: flav_short; TIGR01753 393127005560 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 393127005561 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 393127005562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127005563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127005564 putative substrate translocation pore; other site 393127005565 rod-share determining protein MreBH; Provisional; Region: PRK13929 393127005566 MreB and similar proteins; Region: MreB_like; cd10225 393127005567 nucleotide binding site [chemical binding]; other site 393127005568 Mg binding site [ion binding]; other site 393127005569 putative protofilament interaction site [polypeptide binding]; other site 393127005570 RodZ interaction site [polypeptide binding]; other site 393127005571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 393127005572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005573 S-adenosylmethionine binding site [chemical binding]; other site 393127005574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127005575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127005576 Uncharacterized conserved protein [Function unknown]; Region: COG4748 393127005577 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 393127005578 Uncharacterized conserved protein [Function unknown]; Region: COG3589 393127005579 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 393127005580 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127005581 methionine cluster; other site 393127005582 active site 393127005583 phosphorylation site [posttranslational modification] 393127005584 metal binding site [ion binding]; metal-binding site 393127005585 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127005586 active site 393127005587 P-loop; other site 393127005588 phosphorylation site [posttranslational modification] 393127005589 Transcriptional antiterminator [Transcription]; Region: COG3933 393127005590 PRD domain; Region: PRD; pfam00874 393127005591 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127005592 active pocket/dimerization site; other site 393127005593 active site 393127005594 phosphorylation site [posttranslational modification] 393127005595 PRD domain; Region: PRD; pfam00874 393127005596 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 393127005597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393127005598 ATP binding site [chemical binding]; other site 393127005599 putative Mg++ binding site [ion binding]; other site 393127005600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127005601 nucleotide binding region [chemical binding]; other site 393127005602 ATP-binding site [chemical binding]; other site 393127005603 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393127005604 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127005605 Walker A/P-loop; other site 393127005606 ATP binding site [chemical binding]; other site 393127005607 Q-loop/lid; other site 393127005608 ABC transporter signature motif; other site 393127005609 Walker B; other site 393127005610 D-loop; other site 393127005611 H-loop/switch region; other site 393127005612 Predicted transcriptional regulators [Transcription]; Region: COG1725 393127005613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127005614 DNA-binding site [nucleotide binding]; DNA binding site 393127005615 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127005616 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127005617 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127005618 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127005619 DNA binding site [nucleotide binding] 393127005620 domain linker motif; other site 393127005621 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127005622 dimerization interface [polypeptide binding]; other site 393127005623 ligand binding site [chemical binding]; other site 393127005624 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 393127005625 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 393127005626 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 393127005627 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 393127005628 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393127005629 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127005630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127005631 dimer interface [polypeptide binding]; other site 393127005632 conserved gate region; other site 393127005633 putative PBP binding loops; other site 393127005634 ABC-ATPase subunit interface; other site 393127005635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127005636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127005637 dimer interface [polypeptide binding]; other site 393127005638 conserved gate region; other site 393127005639 putative PBP binding loops; other site 393127005640 ABC-ATPase subunit interface; other site 393127005641 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 393127005642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 393127005643 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 393127005644 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 393127005645 active site 393127005646 dimer interface [polypeptide binding]; other site 393127005647 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 393127005648 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 393127005649 active site 393127005650 FMN binding site [chemical binding]; other site 393127005651 substrate binding site [chemical binding]; other site 393127005652 3Fe-4S cluster binding site [ion binding]; other site 393127005653 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 393127005654 domain interface; other site 393127005655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127005656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127005657 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393127005658 putative dimerization interface [polypeptide binding]; other site 393127005659 Predicted acetyltransferase [General function prediction only]; Region: COG3153 393127005660 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 393127005661 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 393127005662 putative active site [active] 393127005663 metal binding site [ion binding]; metal-binding site 393127005664 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393127005665 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393127005666 substrate binding pocket [chemical binding]; other site 393127005667 membrane-bound complex binding site; other site 393127005668 hinge residues; other site 393127005669 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127005670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127005671 Walker A/P-loop; other site 393127005672 ATP binding site [chemical binding]; other site 393127005673 Q-loop/lid; other site 393127005674 ABC transporter signature motif; other site 393127005675 Walker B; other site 393127005676 D-loop; other site 393127005677 H-loop/switch region; other site 393127005678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127005679 dimer interface [polypeptide binding]; other site 393127005680 conserved gate region; other site 393127005681 putative PBP binding loops; other site 393127005682 ABC-ATPase subunit interface; other site 393127005683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 393127005684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 393127005685 dimer interface [polypeptide binding]; other site 393127005686 phosphorylation site [posttranslational modification] 393127005687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127005688 ATP binding site [chemical binding]; other site 393127005689 Mg2+ binding site [ion binding]; other site 393127005690 G-X-G motif; other site 393127005691 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 393127005692 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393127005693 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 393127005694 active site 393127005695 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 393127005696 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 393127005697 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 393127005698 putative NAD(P) binding site [chemical binding]; other site 393127005699 active site 393127005700 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127005701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127005702 active site 393127005703 phosphorylation site [posttranslational modification] 393127005704 intermolecular recognition site; other site 393127005705 dimerization interface [polypeptide binding]; other site 393127005706 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127005707 DNA binding site [nucleotide binding] 393127005708 FtsX-like permease family; Region: FtsX; pfam02687 393127005709 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127005710 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127005711 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127005712 Walker A/P-loop; other site 393127005713 ATP binding site [chemical binding]; other site 393127005714 Q-loop/lid; other site 393127005715 ABC transporter signature motif; other site 393127005716 Walker B; other site 393127005717 D-loop; other site 393127005718 H-loop/switch region; other site 393127005719 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 393127005720 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 393127005721 ADP binding site [chemical binding]; other site 393127005722 magnesium binding site [ion binding]; other site 393127005723 putative shikimate binding site; other site 393127005724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 393127005725 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 393127005726 TRAM domain; Region: TRAM; pfam01938 393127005727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005728 S-adenosylmethionine binding site [chemical binding]; other site 393127005729 putative lipid kinase; Reviewed; Region: PRK13337 393127005730 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393127005731 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 393127005732 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 393127005733 GatB domain; Region: GatB_Yqey; pfam02637 393127005734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 393127005735 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 393127005736 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 393127005737 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 393127005738 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 393127005739 putative dimer interface [polypeptide binding]; other site 393127005740 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 393127005741 putative dimer interface [polypeptide binding]; other site 393127005742 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 393127005743 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 393127005744 nucleotide binding pocket [chemical binding]; other site 393127005745 K-X-D-G motif; other site 393127005746 catalytic site [active] 393127005747 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 393127005748 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 393127005749 Dimer interface [polypeptide binding]; other site 393127005750 BRCT sequence motif; other site 393127005751 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 393127005752 Part of AAA domain; Region: AAA_19; pfam13245 393127005753 Family description; Region: UvrD_C_2; pfam13538 393127005754 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 393127005755 PcrB family; Region: PcrB; pfam01884 393127005756 substrate binding site [chemical binding]; other site 393127005757 putative active site [active] 393127005758 dimer interface [polypeptide binding]; other site 393127005759 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 393127005760 Na2 binding site [ion binding]; other site 393127005761 putative substrate binding site 1 [chemical binding]; other site 393127005762 Na binding site 1 [ion binding]; other site 393127005763 putative substrate binding site 2 [chemical binding]; other site 393127005764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 393127005765 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 393127005766 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 393127005767 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 393127005768 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 393127005769 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 393127005770 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 393127005771 purine monophosphate binding site [chemical binding]; other site 393127005772 dimer interface [polypeptide binding]; other site 393127005773 putative catalytic residues [active] 393127005774 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 393127005775 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 393127005776 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 393127005777 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 393127005778 active site 393127005779 substrate binding site [chemical binding]; other site 393127005780 cosubstrate binding site; other site 393127005781 catalytic site [active] 393127005782 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 393127005783 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 393127005784 dimerization interface [polypeptide binding]; other site 393127005785 putative ATP binding site [chemical binding]; other site 393127005786 amidophosphoribosyltransferase; Provisional; Region: PRK06781 393127005787 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 393127005788 active site 393127005789 tetramer interface [polypeptide binding]; other site 393127005790 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127005791 active site 393127005792 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 393127005793 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 393127005794 dimerization interface [polypeptide binding]; other site 393127005795 ATP binding site [chemical binding]; other site 393127005796 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 393127005797 dimerization interface [polypeptide binding]; other site 393127005798 ATP binding site [chemical binding]; other site 393127005799 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 393127005800 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 393127005801 putative active site [active] 393127005802 catalytic triad [active] 393127005803 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 393127005804 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 393127005805 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 393127005806 ATP binding site [chemical binding]; other site 393127005807 active site 393127005808 substrate binding site [chemical binding]; other site 393127005809 adenylosuccinate lyase; Provisional; Region: PRK07492 393127005810 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 393127005811 tetramer interface [polypeptide binding]; other site 393127005812 active site 393127005813 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 393127005814 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 393127005815 NAD binding site [chemical binding]; other site 393127005816 ATP-grasp domain; Region: ATP-grasp; pfam02222 393127005817 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 393127005818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 393127005819 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127005820 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 393127005821 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127005822 Zn2+ binding site [ion binding]; other site 393127005823 Mg2+ binding site [ion binding]; other site 393127005824 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393127005825 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393127005826 Walker A/P-loop; other site 393127005827 ATP binding site [chemical binding]; other site 393127005828 Q-loop/lid; other site 393127005829 ABC transporter signature motif; other site 393127005830 Walker B; other site 393127005831 D-loop; other site 393127005832 H-loop/switch region; other site 393127005833 peptidase T; Region: peptidase-T; TIGR01882 393127005834 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 393127005835 metal binding site [ion binding]; metal-binding site 393127005836 dimer interface [polypeptide binding]; other site 393127005837 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 393127005838 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 393127005839 active site 393127005840 putative catalytic site [active] 393127005841 DNA binding site [nucleotide binding] 393127005842 putative phosphate binding site [ion binding]; other site 393127005843 metal binding site A [ion binding]; metal-binding site 393127005844 AP binding site [nucleotide binding]; other site 393127005845 metal binding site B [ion binding]; metal-binding site 393127005846 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 393127005847 23S rRNA binding site [nucleotide binding]; other site 393127005848 L21 binding site [polypeptide binding]; other site 393127005849 L13 binding site [polypeptide binding]; other site 393127005850 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 393127005851 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 393127005852 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 393127005853 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 393127005854 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127005855 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127005856 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127005857 Substrate binding site [chemical binding]; other site 393127005858 Leucine rich repeat; Region: LRR_8; pfam13855 393127005859 LRR adjacent; Region: LRR_adjacent; pfam08191 393127005860 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 393127005861 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 393127005862 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393127005863 DNA binding residues [nucleotide binding] 393127005864 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393127005865 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393127005866 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127005867 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 393127005868 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 393127005869 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 393127005870 RimM N-terminal domain; Region: RimM; pfam01782 393127005871 PRC-barrel domain; Region: PRC; pfam05239 393127005872 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 393127005873 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 393127005874 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 393127005875 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 393127005876 catalytic triad [active] 393127005877 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 393127005878 KH domain; Region: KH_4; pfam13083 393127005879 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 393127005880 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 393127005881 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 393127005882 signal recognition particle protein; Provisional; Region: PRK10867 393127005883 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 393127005884 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393127005885 P loop; other site 393127005886 GTP binding site [chemical binding]; other site 393127005887 Signal peptide binding domain; Region: SRP_SPB; pfam02978 393127005888 putative DNA-binding protein; Validated; Region: PRK00118 393127005889 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 393127005890 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 393127005891 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 393127005892 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 393127005893 P loop; other site 393127005894 GTP binding site [chemical binding]; other site 393127005895 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 393127005896 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 393127005897 Walker A/P-loop; other site 393127005898 ATP binding site [chemical binding]; other site 393127005899 Q-loop/lid; other site 393127005900 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 393127005901 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 393127005902 ABC transporter signature motif; other site 393127005903 Walker B; other site 393127005904 D-loop; other site 393127005905 H-loop/switch region; other site 393127005906 ribonuclease III; Reviewed; Region: rnc; PRK00102 393127005907 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 393127005908 dimerization interface [polypeptide binding]; other site 393127005909 active site 393127005910 metal binding site [ion binding]; metal-binding site 393127005911 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 393127005912 dsRNA binding site [nucleotide binding]; other site 393127005913 acyl carrier protein; Provisional; Region: acpP; PRK00982 393127005914 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 393127005915 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 393127005916 NAD(P) binding site [chemical binding]; other site 393127005917 homotetramer interface [polypeptide binding]; other site 393127005918 homodimer interface [polypeptide binding]; other site 393127005919 active site 393127005920 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 393127005921 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 393127005922 putative phosphate acyltransferase; Provisional; Region: PRK05331 393127005923 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 393127005924 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 393127005925 active site 2 [active] 393127005926 active site 1 [active] 393127005927 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 393127005928 Y-family of DNA polymerases; Region: PolY; cl12025 393127005929 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 393127005930 generic binding surface II; other site 393127005931 ssDNA binding site; other site 393127005932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127005933 ATP binding site [chemical binding]; other site 393127005934 putative Mg++ binding site [ion binding]; other site 393127005935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127005936 nucleotide binding region [chemical binding]; other site 393127005937 ATP-binding site [chemical binding]; other site 393127005938 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 393127005939 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 393127005940 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 393127005941 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 393127005942 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 393127005943 putative L-serine binding site [chemical binding]; other site 393127005944 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 393127005945 DAK2 domain; Region: Dak2; pfam02734 393127005946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 393127005947 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 393127005948 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 393127005949 Thiamine pyrophosphokinase; Region: TPK; cd07995 393127005950 active site 393127005951 dimerization interface [polypeptide binding]; other site 393127005952 thiamine binding site [chemical binding]; other site 393127005953 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127005954 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127005955 substrate binding site [chemical binding]; other site 393127005956 hexamer interface [polypeptide binding]; other site 393127005957 metal binding site [ion binding]; metal-binding site 393127005958 GTPase RsgA; Reviewed; Region: PRK00098 393127005959 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 393127005960 RNA binding site [nucleotide binding]; other site 393127005961 homodimer interface [polypeptide binding]; other site 393127005962 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 393127005963 GTPase/Zn-binding domain interface [polypeptide binding]; other site 393127005964 GTP/Mg2+ binding site [chemical binding]; other site 393127005965 G4 box; other site 393127005966 G1 box; other site 393127005967 Switch I region; other site 393127005968 G2 box; other site 393127005969 G3 box; other site 393127005970 Switch II region; other site 393127005971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 393127005972 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 393127005973 active site 393127005974 ATP binding site [chemical binding]; other site 393127005975 substrate binding site [chemical binding]; other site 393127005976 activation loop (A-loop); other site 393127005977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 393127005978 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393127005979 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393127005980 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 393127005981 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 393127005982 Protein phosphatase 2C; Region: PP2C; pfam00481 393127005983 active site 393127005984 16S rRNA methyltransferase B; Provisional; Region: PRK14902 393127005985 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 393127005986 putative RNA binding site [nucleotide binding]; other site 393127005987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127005988 S-adenosylmethionine binding site [chemical binding]; other site 393127005989 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 393127005990 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 393127005991 putative active site [active] 393127005992 substrate binding site [chemical binding]; other site 393127005993 putative cosubstrate binding site; other site 393127005994 catalytic site [active] 393127005995 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 393127005996 substrate binding site [chemical binding]; other site 393127005997 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 393127005998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127005999 ATP binding site [chemical binding]; other site 393127006000 putative Mg++ binding site [ion binding]; other site 393127006001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127006002 ATP-binding site [chemical binding]; other site 393127006003 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 393127006004 Flavoprotein; Region: Flavoprotein; pfam02441 393127006005 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 393127006006 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 393127006007 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 393127006008 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 393127006009 catalytic site [active] 393127006010 G-X2-G-X-G-K; other site 393127006011 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 393127006012 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 393127006013 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 393127006014 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 393127006015 Domain of unknown function (DUF814); Region: DUF814; pfam05670 393127006016 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 393127006017 putative NAD(P) binding site [chemical binding]; other site 393127006018 homodimer interface [polypeptide binding]; other site 393127006019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127006020 active site 393127006021 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 393127006022 active site 393127006023 dimer interface [polypeptide binding]; other site 393127006024 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 393127006025 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 393127006026 heterodimer interface [polypeptide binding]; other site 393127006027 active site 393127006028 FMN binding site [chemical binding]; other site 393127006029 homodimer interface [polypeptide binding]; other site 393127006030 substrate binding site [chemical binding]; other site 393127006031 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 393127006032 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 393127006033 FAD binding pocket [chemical binding]; other site 393127006034 FAD binding motif [chemical binding]; other site 393127006035 phosphate binding motif [ion binding]; other site 393127006036 beta-alpha-beta structure motif; other site 393127006037 NAD binding pocket [chemical binding]; other site 393127006038 Iron coordination center [ion binding]; other site 393127006039 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 393127006040 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393127006041 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 393127006042 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 393127006043 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 393127006044 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393127006045 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 393127006046 IMP binding site; other site 393127006047 dimer interface [polypeptide binding]; other site 393127006048 interdomain contacts; other site 393127006049 partial ornithine binding site; other site 393127006050 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 393127006051 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 393127006052 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 393127006053 catalytic site [active] 393127006054 subunit interface [polypeptide binding]; other site 393127006055 dihydroorotase; Validated; Region: pyrC; PRK09357 393127006056 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 393127006057 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 393127006058 active site 393127006059 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 393127006060 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 393127006061 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 393127006062 uracil transporter; Provisional; Region: PRK10720 393127006063 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 393127006064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127006065 active site 393127006066 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 393127006067 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393127006068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127006069 RNA binding surface [nucleotide binding]; other site 393127006070 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393127006071 active site 393127006072 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 393127006073 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393127006074 Sulfate transporter family; Region: Sulfate_transp; pfam00916 393127006075 multidrug efflux protein; Reviewed; Region: PRK01766 393127006076 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 393127006077 cation binding site [ion binding]; other site 393127006078 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 393127006079 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 393127006080 metal binding site [ion binding]; metal-binding site 393127006081 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 393127006082 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127006083 ABC-ATPase subunit interface; other site 393127006084 dimer interface [polypeptide binding]; other site 393127006085 putative PBP binding regions; other site 393127006086 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 393127006087 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 393127006088 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127006089 MarR family; Region: MarR; pfam01047 393127006090 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 393127006091 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 393127006092 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 393127006093 protein binding site [polypeptide binding]; other site 393127006094 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 393127006095 Catalytic dyad [active] 393127006096 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 393127006097 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 393127006098 metal-binding site [ion binding] 393127006099 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127006100 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 393127006101 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 393127006102 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127006103 motif II; other site 393127006104 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 393127006105 putative homodimer interface [polypeptide binding]; other site 393127006106 putative homotetramer interface [polypeptide binding]; other site 393127006107 putative allosteric switch controlling residues; other site 393127006108 putative metal binding site [ion binding]; other site 393127006109 putative homodimer-homodimer interface [polypeptide binding]; other site 393127006110 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 393127006111 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 393127006112 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 393127006113 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 393127006114 hypothetical protein; Provisional; Region: PRK13672 393127006115 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127006116 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127006117 methionine sulfoxide reductase B; Provisional; Region: PRK00222 393127006118 SelR domain; Region: SelR; pfam01641 393127006119 methionine sulfoxide reductase A; Provisional; Region: PRK14054 393127006120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 393127006121 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 393127006122 active site 393127006123 catalytic triad [active] 393127006124 oxyanion hole [active] 393127006125 EDD domain protein, DegV family; Region: DegV; TIGR00762 393127006126 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393127006127 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 393127006128 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 393127006129 HTH domain; Region: HTH_11; pfam08279 393127006130 FOG: CBS domain [General function prediction only]; Region: COG0517 393127006131 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 393127006132 PEP synthetase regulatory protein; Provisional; Region: PRK05339 393127006133 pyruvate phosphate dikinase; Provisional; Region: PRK09279 393127006134 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 393127006135 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 393127006136 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 393127006137 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127006138 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 393127006139 Predicted membrane protein [Function unknown]; Region: COG4129 393127006140 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 393127006141 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 393127006142 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 393127006143 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 393127006144 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 393127006145 active site 393127006146 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 393127006147 substrate binding site [chemical binding]; other site 393127006148 metal binding site [ion binding]; metal-binding site 393127006149 Methyltransferase domain; Region: Methyltransf_23; pfam13489 393127006150 Methyltransferase domain; Region: Methyltransf_18; pfam12847 393127006151 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 393127006152 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 393127006153 folate binding site [chemical binding]; other site 393127006154 NADP+ binding site [chemical binding]; other site 393127006155 thymidylate synthase; Region: thym_sym; TIGR03284 393127006156 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 393127006157 dimerization interface [polypeptide binding]; other site 393127006158 active site 393127006159 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393127006160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127006161 Walker A/P-loop; other site 393127006162 ATP binding site [chemical binding]; other site 393127006163 Q-loop/lid; other site 393127006164 ABC transporter signature motif; other site 393127006165 Walker B; other site 393127006166 D-loop; other site 393127006167 H-loop/switch region; other site 393127006168 ABC transporter; Region: ABC_tran_2; pfam12848 393127006169 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127006170 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 393127006171 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 393127006172 Potassium binding sites [ion binding]; other site 393127006173 Cesium cation binding sites [ion binding]; other site 393127006174 manganese transport transcriptional regulator; Provisional; Region: PRK03902 393127006175 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 393127006176 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 393127006177 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393127006178 DNA-binding site [nucleotide binding]; DNA binding site 393127006179 RNA-binding motif; other site 393127006180 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 393127006181 RNA/DNA hybrid binding site [nucleotide binding]; other site 393127006182 active site 393127006183 5'-3' exonuclease; Region: 53EXOc; smart00475 393127006184 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 393127006185 active site 393127006186 metal binding site 1 [ion binding]; metal-binding site 393127006187 putative 5' ssDNA interaction site; other site 393127006188 metal binding site 3; metal-binding site 393127006189 metal binding site 2 [ion binding]; metal-binding site 393127006190 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 393127006191 putative DNA binding site [nucleotide binding]; other site 393127006192 putative metal binding site [ion binding]; other site 393127006193 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 393127006194 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 393127006195 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 393127006196 putative active site [active] 393127006197 xanthine permease; Region: pbuX; TIGR03173 393127006198 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127006199 active site 393127006200 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 393127006201 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 393127006202 active site 393127006203 Zn binding site [ion binding]; other site 393127006204 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 393127006205 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 393127006206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 393127006207 cell division protein GpsB; Provisional; Region: PRK14127 393127006208 DivIVA domain; Region: DivI1A_domain; TIGR03544 393127006209 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 393127006210 hypothetical protein; Provisional; Region: PRK13660 393127006211 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 393127006212 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 393127006213 Transglycosylase; Region: Transgly; pfam00912 393127006214 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 393127006215 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393127006216 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 393127006217 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 393127006218 minor groove reading motif; other site 393127006219 helix-hairpin-helix signature motif; other site 393127006220 substrate binding pocket [chemical binding]; other site 393127006221 active site 393127006222 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 393127006223 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 393127006224 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 393127006225 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 393127006226 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 393127006227 putative dimer interface [polypeptide binding]; other site 393127006228 putative anticodon binding site; other site 393127006229 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 393127006230 homodimer interface [polypeptide binding]; other site 393127006231 motif 1; other site 393127006232 motif 2; other site 393127006233 active site 393127006234 motif 3; other site 393127006235 aspartate aminotransferase; Provisional; Region: PRK05764 393127006236 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127006237 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127006238 homodimer interface [polypeptide binding]; other site 393127006239 catalytic residue [active] 393127006240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 393127006241 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 393127006242 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 393127006243 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 393127006244 active site 393127006245 catalytic site [active] 393127006246 substrate binding site [chemical binding]; other site 393127006247 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 393127006248 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 393127006249 putative Mg++ binding site [ion binding]; other site 393127006250 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 393127006251 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 393127006252 tetramerization interface [polypeptide binding]; other site 393127006253 active site 393127006254 pantoate--beta-alanine ligase; Region: panC; TIGR00018 393127006255 Pantoate-beta-alanine ligase; Region: PanC; cd00560 393127006256 active site 393127006257 ATP-binding site [chemical binding]; other site 393127006258 pantoate-binding site; other site 393127006259 HXXH motif; other site 393127006260 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 393127006261 active site 393127006262 oligomerization interface [polypeptide binding]; other site 393127006263 metal binding site [ion binding]; metal-binding site 393127006264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127006265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393127006266 catalytic residues [active] 393127006267 Biotin operon repressor [Transcription]; Region: BirA; COG1654 393127006268 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 393127006269 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 393127006270 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 393127006271 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 393127006272 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 393127006273 active site 393127006274 NTP binding site [chemical binding]; other site 393127006275 metal binding triad [ion binding]; metal-binding site 393127006276 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 393127006277 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 393127006278 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 393127006279 active site 393127006280 dimer interfaces [polypeptide binding]; other site 393127006281 catalytic residues [active] 393127006282 dihydrodipicolinate reductase; Provisional; Region: PRK00048 393127006283 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 393127006284 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 393127006285 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 393127006286 homodimer interface [polypeptide binding]; other site 393127006287 metal binding site [ion binding]; metal-binding site 393127006288 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393127006289 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127006290 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127006291 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127006292 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 393127006293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393127006294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393127006295 metal binding site [ion binding]; metal-binding site 393127006296 active site 393127006297 I-site; other site 393127006298 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 393127006299 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393127006300 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393127006301 metal binding site [ion binding]; metal-binding site 393127006302 active site 393127006303 I-site; other site 393127006304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 393127006305 malate dehydrogenase; Provisional; Region: PRK13529 393127006306 Malic enzyme, N-terminal domain; Region: malic; pfam00390 393127006307 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 393127006308 NAD(P) binding pocket [chemical binding]; other site 393127006309 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 393127006310 Beta-lactamase; Region: Beta-lactamase; pfam00144 393127006311 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 393127006312 Pyruvate formate lyase 1; Region: PFL1; cd01678 393127006313 coenzyme A binding site [chemical binding]; other site 393127006314 active site 393127006315 catalytic residues [active] 393127006316 glycine loop; other site 393127006317 HI0933-like protein; Region: HI0933_like; pfam03486 393127006318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127006319 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 393127006320 Predicted membrane protein [Function unknown]; Region: COG4347 393127006321 hypothetical protein; Provisional; Region: PRK03636 393127006322 UPF0302 domain; Region: UPF0302; pfam08864 393127006323 IDEAL domain; Region: IDEAL; pfam08858 393127006324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 393127006325 binding surface 393127006326 TPR motif; other site 393127006327 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127006328 binding surface 393127006329 Tetratricopeptide repeat; Region: TPR_16; pfam13432 393127006330 TPR motif; other site 393127006331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 393127006332 binding surface 393127006333 TPR motif; other site 393127006334 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 393127006335 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 393127006336 hinge; other site 393127006337 active site 393127006338 prephenate dehydrogenase; Validated; Region: PRK06545 393127006339 prephenate dehydrogenase; Validated; Region: PRK08507 393127006340 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 393127006341 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 393127006342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127006343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127006344 homodimer interface [polypeptide binding]; other site 393127006345 catalytic residue [active] 393127006346 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 393127006347 homotrimer interaction site [polypeptide binding]; other site 393127006348 active site 393127006349 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 393127006350 active site 393127006351 dimer interface [polypeptide binding]; other site 393127006352 metal binding site [ion binding]; metal-binding site 393127006353 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 393127006354 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 393127006355 Tetramer interface [polypeptide binding]; other site 393127006356 active site 393127006357 FMN-binding site [chemical binding]; other site 393127006358 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 393127006359 active site 393127006360 multimer interface [polypeptide binding]; other site 393127006361 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393127006362 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393127006363 substrate binding pocket [chemical binding]; other site 393127006364 chain length determination region; other site 393127006365 substrate-Mg2+ binding site; other site 393127006366 catalytic residues [active] 393127006367 aspartate-rich region 1; other site 393127006368 active site lid residues [active] 393127006369 aspartate-rich region 2; other site 393127006370 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 393127006371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127006372 S-adenosylmethionine binding site [chemical binding]; other site 393127006373 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 393127006374 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 393127006375 homodecamer interface [polypeptide binding]; other site 393127006376 GTP cyclohydrolase I; Provisional; Region: PLN03044 393127006377 active site 393127006378 putative catalytic site residues [active] 393127006379 zinc binding site [ion binding]; other site 393127006380 GTP-CH-I/GFRP interaction surface; other site 393127006381 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 393127006382 IHF dimer interface [polypeptide binding]; other site 393127006383 IHF - DNA interface [nucleotide binding]; other site 393127006384 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 393127006385 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 393127006386 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 393127006387 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 393127006388 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 393127006389 GTP-binding protein Der; Reviewed; Region: PRK00093 393127006390 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 393127006391 G1 box; other site 393127006392 GTP/Mg2+ binding site [chemical binding]; other site 393127006393 Switch I region; other site 393127006394 G2 box; other site 393127006395 Switch II region; other site 393127006396 G3 box; other site 393127006397 G4 box; other site 393127006398 G5 box; other site 393127006399 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 393127006400 G1 box; other site 393127006401 GTP/Mg2+ binding site [chemical binding]; other site 393127006402 Switch I region; other site 393127006403 G2 box; other site 393127006404 G3 box; other site 393127006405 Switch II region; other site 393127006406 G4 box; other site 393127006407 G5 box; other site 393127006408 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 393127006409 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 393127006410 RNA binding site [nucleotide binding]; other site 393127006411 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 393127006412 RNA binding site [nucleotide binding]; other site 393127006413 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 393127006414 RNA binding site [nucleotide binding]; other site 393127006415 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393127006416 RNA binding site [nucleotide binding]; other site 393127006417 cytidylate kinase; Provisional; Region: cmk; PRK00023 393127006418 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 393127006419 CMP-binding site; other site 393127006420 The sites determining sugar specificity; other site 393127006421 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 393127006422 active site 393127006423 homotetramer interface [polypeptide binding]; other site 393127006424 homodimer interface [polypeptide binding]; other site 393127006425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127006426 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 393127006427 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 393127006428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127006429 ATP binding site [chemical binding]; other site 393127006430 putative Mg++ binding site [ion binding]; other site 393127006431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127006432 nucleotide binding region [chemical binding]; other site 393127006433 ATP-binding site [chemical binding]; other site 393127006434 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 393127006435 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 393127006436 Predicted membrane protein [Function unknown]; Region: COG3601 393127006437 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 393127006438 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 393127006439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127006440 dimerization interface [polypeptide binding]; other site 393127006441 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 393127006442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127006443 dimer interface [polypeptide binding]; other site 393127006444 phosphorylation site [posttranslational modification] 393127006445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127006446 ATP binding site [chemical binding]; other site 393127006447 Mg2+ binding site [ion binding]; other site 393127006448 G-X-G motif; other site 393127006449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127006450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127006451 active site 393127006452 phosphorylation site [posttranslational modification] 393127006453 intermolecular recognition site; other site 393127006454 dimerization interface [polypeptide binding]; other site 393127006455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127006456 DNA binding site [nucleotide binding] 393127006457 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 393127006458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127006459 RNA binding surface [nucleotide binding]; other site 393127006460 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 393127006461 active site 393127006462 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 393127006463 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 393127006464 diaminopimelate decarboxylase; Region: lysA; TIGR01048 393127006465 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 393127006466 active site 393127006467 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393127006468 substrate binding site [chemical binding]; other site 393127006469 catalytic residues [active] 393127006470 dimer interface [polypeptide binding]; other site 393127006471 purine nucleoside phosphorylase; Provisional; Region: PRK08202 393127006472 phosphopentomutase; Provisional; Region: PRK05362 393127006473 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 393127006474 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 393127006475 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 393127006476 active site 393127006477 Int/Topo IB signature motif; other site 393127006478 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 393127006479 metal binding site 2 [ion binding]; metal-binding site 393127006480 putative DNA binding helix; other site 393127006481 metal binding site 1 [ion binding]; metal-binding site 393127006482 dimer interface [polypeptide binding]; other site 393127006483 structural Zn2+ binding site [ion binding]; other site 393127006484 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393127006485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127006486 ABC-ATPase subunit interface; other site 393127006487 dimer interface [polypeptide binding]; other site 393127006488 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393127006489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127006490 ABC-ATPase subunit interface; other site 393127006491 dimer interface [polypeptide binding]; other site 393127006492 putative PBP binding regions; other site 393127006493 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 393127006494 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 393127006495 putative ligand binding residues [chemical binding]; other site 393127006496 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393127006497 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393127006498 Walker A/P-loop; other site 393127006499 ATP binding site [chemical binding]; other site 393127006500 Q-loop/lid; other site 393127006501 ABC transporter signature motif; other site 393127006502 Walker B; other site 393127006503 D-loop; other site 393127006504 H-loop/switch region; other site 393127006505 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 393127006506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127006507 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127006508 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127006509 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 393127006510 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393127006511 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127006512 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127006513 Walker A/P-loop; other site 393127006514 ATP binding site [chemical binding]; other site 393127006515 Q-loop/lid; other site 393127006516 ABC transporter signature motif; other site 393127006517 Walker B; other site 393127006518 D-loop; other site 393127006519 H-loop/switch region; other site 393127006520 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 393127006521 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 393127006522 dimer interface [polypeptide binding]; other site 393127006523 ADP-ribose binding site [chemical binding]; other site 393127006524 active site 393127006525 nudix motif; other site 393127006526 metal binding site [ion binding]; metal-binding site 393127006527 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 393127006528 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 393127006529 Creatinine amidohydrolase; Region: Creatininase; pfam02633 393127006530 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 393127006531 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 393127006532 active site 393127006533 intersubunit interface [polypeptide binding]; other site 393127006534 catalytic residue [active] 393127006535 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 393127006536 active site 393127006537 substrate binding pocket [chemical binding]; other site 393127006538 homodimer interaction site [polypeptide binding]; other site 393127006539 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 393127006540 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 393127006541 active site 393127006542 P-loop; other site 393127006543 phosphorylation site [posttranslational modification] 393127006544 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127006545 active site 393127006546 phosphorylation site [posttranslational modification] 393127006547 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127006548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127006549 DNA-binding site [nucleotide binding]; DNA binding site 393127006550 UTRA domain; Region: UTRA; pfam07702 393127006551 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 393127006552 active site 393127006553 DNA polymerase IV; Validated; Region: PRK02406 393127006554 DNA binding site [nucleotide binding] 393127006555 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 393127006556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 393127006557 NAD(P) binding site [chemical binding]; other site 393127006558 active site 393127006559 ribonuclease Z; Region: RNase_Z; TIGR02651 393127006560 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 393127006561 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 393127006562 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 393127006563 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 393127006564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393127006565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127006566 Coenzyme A binding pocket [chemical binding]; other site 393127006567 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 393127006568 6-phosphogluconate dehydratase; Region: edd; TIGR01196 393127006569 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 393127006570 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393127006571 PYR/PP interface [polypeptide binding]; other site 393127006572 dimer interface [polypeptide binding]; other site 393127006573 TPP binding site [chemical binding]; other site 393127006574 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393127006575 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 393127006576 TPP-binding site [chemical binding]; other site 393127006577 dimer interface [polypeptide binding]; other site 393127006578 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 393127006579 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 393127006580 putative valine binding site [chemical binding]; other site 393127006581 dimer interface [polypeptide binding]; other site 393127006582 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 393127006583 ketol-acid reductoisomerase; Provisional; Region: PRK05479 393127006584 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 393127006585 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 393127006586 2-isopropylmalate synthase; Validated; Region: PRK00915 393127006587 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 393127006588 active site 393127006589 catalytic residues [active] 393127006590 metal binding site [ion binding]; metal-binding site 393127006591 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 393127006592 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 393127006593 tartrate dehydrogenase; Region: TTC; TIGR02089 393127006594 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 393127006595 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 393127006596 substrate binding site [chemical binding]; other site 393127006597 ligand binding site [chemical binding]; other site 393127006598 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 393127006599 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 393127006600 substrate binding site [chemical binding]; other site 393127006601 threonine dehydratase; Validated; Region: PRK08639 393127006602 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 393127006603 tetramer interface [polypeptide binding]; other site 393127006604 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127006605 catalytic residue [active] 393127006606 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 393127006607 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 393127006608 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 393127006609 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 393127006610 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 393127006611 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 393127006612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127006613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127006614 DNA binding site [nucleotide binding] 393127006615 domain linker motif; other site 393127006616 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127006617 dimerization interface [polypeptide binding]; other site 393127006618 ligand binding site [chemical binding]; other site 393127006619 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 393127006620 intersubunit interface [polypeptide binding]; other site 393127006621 active site 393127006622 catalytic residue [active] 393127006623 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393127006624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 393127006625 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393127006626 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 393127006627 active pocket/dimerization site; other site 393127006628 active site 393127006629 phosphorylation site [posttranslational modification] 393127006630 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393127006631 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 393127006632 putative active site [active] 393127006633 SIS domain; Region: SIS; pfam01380 393127006634 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 393127006635 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 393127006636 dimer interface [polypeptide binding]; other site 393127006637 active site 393127006638 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 393127006639 dimer interface [polypeptide binding]; other site 393127006640 active site 393127006641 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 393127006642 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 393127006643 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 393127006644 active site 393127006645 phosphorylation site [posttranslational modification] 393127006646 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127006647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127006648 DNA-binding site [nucleotide binding]; DNA binding site 393127006649 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 393127006650 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127006651 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127006652 DNA-binding site [nucleotide binding]; DNA binding site 393127006653 UTRA domain; Region: UTRA; pfam07702 393127006654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127006655 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127006656 active site 393127006657 catalytic tetrad [active] 393127006658 acetolactate synthase; Reviewed; Region: PRK08617 393127006659 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 393127006660 PYR/PP interface [polypeptide binding]; other site 393127006661 dimer interface [polypeptide binding]; other site 393127006662 TPP binding site [chemical binding]; other site 393127006663 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 393127006664 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 393127006665 TPP-binding site [chemical binding]; other site 393127006666 dimer interface [polypeptide binding]; other site 393127006667 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127006668 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 393127006669 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 393127006670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127006671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127006672 dimer interface [polypeptide binding]; other site 393127006673 conserved gate region; other site 393127006674 ABC-ATPase subunit interface; other site 393127006675 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 393127006676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127006677 dimer interface [polypeptide binding]; other site 393127006678 conserved gate region; other site 393127006679 ABC-ATPase subunit interface; other site 393127006680 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 393127006681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127006682 active site 393127006683 phosphorylation site [posttranslational modification] 393127006684 intermolecular recognition site; other site 393127006685 dimerization interface [polypeptide binding]; other site 393127006686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127006687 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 393127006688 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127006689 dimerization interface [polypeptide binding]; other site 393127006690 Histidine kinase; Region: His_kinase; pfam06580 393127006691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127006692 ATP binding site [chemical binding]; other site 393127006693 Mg2+ binding site [ion binding]; other site 393127006694 G-X-G motif; other site 393127006695 Predicted integral membrane protein [Function unknown]; Region: COG5578 393127006696 Uncharacterized conserved protein [Function unknown]; Region: COG3538 393127006697 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 393127006698 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393127006699 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 393127006700 active site 393127006701 metal binding site [ion binding]; metal-binding site 393127006702 homodimer interface [polypeptide binding]; other site 393127006703 catalytic site [active] 393127006704 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393127006705 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 393127006706 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 393127006707 active site 393127006708 catalytic site [active] 393127006709 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 393127006710 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 393127006711 DNA-binding site [nucleotide binding]; DNA binding site 393127006712 RNA-binding motif; other site 393127006713 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 393127006714 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 393127006715 active site 393127006716 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 393127006717 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393127006718 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 393127006719 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 393127006720 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 393127006721 HIGH motif; other site 393127006722 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 393127006723 active site 393127006724 KMSKS motif; other site 393127006725 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 393127006726 tRNA binding surface [nucleotide binding]; other site 393127006727 anticodon binding site; other site 393127006728 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 393127006729 DivIVA protein; Region: DivIVA; pfam05103 393127006730 DivIVA domain; Region: DivI1A_domain; TIGR03544 393127006731 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 393127006732 HTH domain; Region: HTH_11; pfam08279 393127006733 3H domain; Region: 3H; pfam02829 393127006734 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 393127006735 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 393127006736 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127006737 catalytic residue [active] 393127006738 L-aspartate oxidase; Provisional; Region: PRK08071 393127006739 L-aspartate oxidase; Provisional; Region: PRK06175 393127006740 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 393127006741 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 393127006742 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 393127006743 dimerization interface [polypeptide binding]; other site 393127006744 active site 393127006745 quinolinate synthetase; Provisional; Region: PRK09375 393127006746 Leucine rich repeat; Region: LRR_8; pfam13855 393127006747 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127006748 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127006749 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 393127006750 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127006751 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127006752 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 393127006753 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127006754 RNA binding surface [nucleotide binding]; other site 393127006755 YGGT family; Region: YGGT; pfam02325 393127006756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 393127006757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 393127006758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 393127006759 catalytic residue [active] 393127006760 cell division protein FtsZ; Validated; Region: PRK09330 393127006761 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 393127006762 nucleotide binding site [chemical binding]; other site 393127006763 SulA interaction site; other site 393127006764 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 393127006765 Cell division protein FtsA; Region: FtsA; smart00842 393127006766 Cell division protein FtsA; Region: FtsA; pfam14450 393127006767 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 393127006768 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 393127006769 Cell division protein FtsQ; Region: FtsQ; pfam03799 393127006770 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 393127006771 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 393127006772 active site 393127006773 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 393127006774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393127006775 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393127006776 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 393127006777 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 393127006778 Mg++ binding site [ion binding]; other site 393127006779 putative catalytic motif [active] 393127006780 putative substrate binding site [chemical binding]; other site 393127006781 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 393127006782 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 393127006783 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 393127006784 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 393127006785 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 393127006786 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 393127006787 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393127006788 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 393127006789 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 393127006790 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 393127006791 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 393127006792 MraW methylase family; Region: Methyltransf_5; pfam01795 393127006793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 393127006794 MraZ protein; Region: MraZ; pfam02381 393127006795 MraZ protein; Region: MraZ; pfam02381 393127006796 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127006797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127006798 putative substrate translocation pore; other site 393127006799 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 393127006800 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 393127006801 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 393127006802 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 393127006803 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 393127006804 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 393127006805 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 393127006806 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 393127006807 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 393127006808 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 393127006809 hypothetical protein; Provisional; Region: PRK13670 393127006810 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393127006811 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393127006812 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 393127006813 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127006814 Walker A/P-loop; other site 393127006815 ATP binding site [chemical binding]; other site 393127006816 Q-loop/lid; other site 393127006817 ABC transporter signature motif; other site 393127006818 Walker B; other site 393127006819 D-loop; other site 393127006820 H-loop/switch region; other site 393127006821 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 393127006822 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 393127006823 protein binding site [polypeptide binding]; other site 393127006824 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 393127006825 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 393127006826 active site 393127006827 (T/H)XGH motif; other site 393127006828 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 393127006829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127006830 S-adenosylmethionine binding site [chemical binding]; other site 393127006831 hypothetical protein; Provisional; Region: PRK02886 393127006832 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 393127006833 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 393127006834 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 393127006835 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 393127006836 UbiA prenyltransferase family; Region: UbiA; pfam01040 393127006837 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 393127006838 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 393127006839 Ion transport protein; Region: Ion_trans; pfam00520 393127006840 Ion channel; Region: Ion_trans_2; pfam07885 393127006841 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 393127006842 MOSC domain; Region: MOSC; pfam03473 393127006843 3-alpha domain; Region: 3-alpha; pfam03475 393127006844 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 393127006845 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 393127006846 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 393127006847 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 393127006848 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 393127006849 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 393127006850 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 393127006851 active site 393127006852 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 393127006853 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 393127006854 ring oligomerisation interface [polypeptide binding]; other site 393127006855 ATP/Mg binding site [chemical binding]; other site 393127006856 stacking interactions; other site 393127006857 hinge regions; other site 393127006858 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 393127006859 oligomerisation interface [polypeptide binding]; other site 393127006860 mobile loop; other site 393127006861 roof hairpin; other site 393127006862 CAAX protease self-immunity; Region: Abi; pfam02517 393127006863 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 393127006864 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 393127006865 CoA binding domain; Region: CoA_binding; pfam02629 393127006866 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393127006867 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127006868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127006869 ABC transporter; Region: ABC_tran_2; pfam12848 393127006870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127006871 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127006872 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 393127006873 UGMP family protein; Validated; Region: PRK09604 393127006874 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 393127006875 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 393127006876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127006877 Coenzyme A binding pocket [chemical binding]; other site 393127006878 Glycoprotease family; Region: Peptidase_M22; pfam00814 393127006879 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 393127006880 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 393127006881 camphor resistance protein CrcB; Provisional; Region: PRK14214 393127006882 camphor resistance protein CrcB; Provisional; Region: PRK14231 393127006883 Uncharacterized conserved protein [Function unknown]; Region: COG4832 393127006884 Phosphotransferase enzyme family; Region: APH; pfam01636 393127006885 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 393127006886 active site 393127006887 substrate binding site [chemical binding]; other site 393127006888 ATP binding site [chemical binding]; other site 393127006889 Cna protein B-type domain; Region: Cna_B; pfam05738 393127006890 Cna protein B-type domain; Region: Cna_B; pfam05738 393127006891 Cna protein B-type domain; Region: Cna_B; pfam05738 393127006892 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127006893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127006894 non-specific DNA binding site [nucleotide binding]; other site 393127006895 salt bridge; other site 393127006896 sequence-specific DNA binding site [nucleotide binding]; other site 393127006897 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393127006898 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393127006899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127006900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127006901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 393127006902 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 393127006903 substrate binding pocket [chemical binding]; other site 393127006904 argininosuccinate synthase; Provisional; Region: PRK13820 393127006905 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 393127006906 ANP binding site [chemical binding]; other site 393127006907 Substrate Binding Site II [chemical binding]; other site 393127006908 Substrate Binding Site I [chemical binding]; other site 393127006909 argininosuccinate lyase; Provisional; Region: PRK00855 393127006910 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 393127006911 active sites [active] 393127006912 tetramer interface [polypeptide binding]; other site 393127006913 BCCT family transporter; Region: BCCT; pfam02028 393127006914 hypothetical protein; Provisional; Region: PRK06357 393127006915 active site 393127006916 intersubunit interface [polypeptide binding]; other site 393127006917 Zn2+ binding site [ion binding]; other site 393127006918 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 393127006919 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 393127006920 putative substrate binding site [chemical binding]; other site 393127006921 putative ATP binding site [chemical binding]; other site 393127006922 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393127006923 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393127006924 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393127006925 active site 393127006926 P-loop; other site 393127006927 phosphorylation site [posttranslational modification] 393127006928 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127006929 active site 393127006930 phosphorylation site [posttranslational modification] 393127006931 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127006932 PRD domain; Region: PRD; pfam00874 393127006933 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127006934 active site 393127006935 P-loop; other site 393127006936 phosphorylation site [posttranslational modification] 393127006937 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 393127006938 active site 393127006939 phosphorylation site [posttranslational modification] 393127006940 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 393127006941 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127006942 DNA-binding site [nucleotide binding]; DNA binding site 393127006943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127006944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127006945 homodimer interface [polypeptide binding]; other site 393127006946 catalytic residue [active] 393127006947 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 393127006948 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 393127006949 active site 393127006950 multimer interface [polypeptide binding]; other site 393127006951 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 393127006952 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 393127006953 predicted active site [active] 393127006954 catalytic triad [active] 393127006955 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 393127006956 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 393127006957 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 393127006958 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 393127006959 G1 box; other site 393127006960 GTP/Mg2+ binding site [chemical binding]; other site 393127006961 Switch I region; other site 393127006962 G2 box; other site 393127006963 G3 box; other site 393127006964 Switch II region; other site 393127006965 G4 box; other site 393127006966 G5 box; other site 393127006967 Nucleoside recognition; Region: Gate; pfam07670 393127006968 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 393127006969 Nucleoside recognition; Region: Gate; pfam07670 393127006970 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 393127006971 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 393127006972 putative active site [active] 393127006973 putative metal binding site [ion binding]; other site 393127006974 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127006975 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 393127006976 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127006977 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 393127006978 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 393127006979 active site 393127006980 dimer interface [polypeptide binding]; other site 393127006981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393127006982 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 393127006983 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 393127006984 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 393127006985 dimer interface [polypeptide binding]; other site 393127006986 FMN binding site [chemical binding]; other site 393127006987 NADPH bind site [chemical binding]; other site 393127006988 Helix-turn-helix domain; Region: HTH_17; pfam12728 393127006989 putative heme peroxidase; Provisional; Region: PRK12276 393127006990 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127006991 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127006992 Walker A/P-loop; other site 393127006993 ATP binding site [chemical binding]; other site 393127006994 Q-loop/lid; other site 393127006995 ABC transporter signature motif; other site 393127006996 Walker B; other site 393127006997 D-loop; other site 393127006998 H-loop/switch region; other site 393127006999 FtsX-like permease family; Region: FtsX; pfam02687 393127007000 FtsX-like permease family; Region: FtsX; pfam02687 393127007001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127007002 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127007003 Coenzyme A binding pocket [chemical binding]; other site 393127007004 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 393127007005 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 393127007006 active site 393127007007 substrate binding site [chemical binding]; other site 393127007008 metal binding site [ion binding]; metal-binding site 393127007009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 393127007010 YbbR-like protein; Region: YbbR; pfam07949 393127007011 YbbR-like protein; Region: YbbR; pfam07949 393127007012 YbbR-like protein; Region: YbbR; pfam07949 393127007013 Uncharacterized conserved protein [Function unknown]; Region: COG1624 393127007014 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 393127007015 maltose phosphorylase; Provisional; Region: PRK13807 393127007016 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 393127007017 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 393127007018 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 393127007019 Predicted integral membrane protein [Function unknown]; Region: COG5521 393127007020 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127007021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007022 dimer interface [polypeptide binding]; other site 393127007023 conserved gate region; other site 393127007024 putative PBP binding loops; other site 393127007025 ABC-ATPase subunit interface; other site 393127007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007027 dimer interface [polypeptide binding]; other site 393127007028 conserved gate region; other site 393127007029 putative PBP binding loops; other site 393127007030 ABC-ATPase subunit interface; other site 393127007031 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 393127007032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127007033 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 393127007034 homodimer interface [polypeptide binding]; other site 393127007035 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 393127007036 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 393127007037 active site 393127007038 homodimer interface [polypeptide binding]; other site 393127007039 catalytic site [active] 393127007040 CAAX protease self-immunity; Region: Abi; pfam02517 393127007041 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127007042 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127007043 DNA binding site [nucleotide binding] 393127007044 domain linker motif; other site 393127007045 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 393127007046 ligand binding site [chemical binding]; other site 393127007047 dimerization interface [polypeptide binding]; other site 393127007048 Amino acid permease; Region: AA_permease_2; pfam13520 393127007049 K+ potassium transporter; Region: K_trans; cl15781 393127007050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127007051 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127007052 ligand binding site [chemical binding]; other site 393127007053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127007054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 393127007055 ligand binding site [chemical binding]; other site 393127007056 flexible hinge region; other site 393127007057 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127007058 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393127007059 intersubunit interface [polypeptide binding]; other site 393127007060 active site 393127007061 zinc binding site [ion binding]; other site 393127007062 Na+ binding site [ion binding]; other site 393127007063 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393127007064 intersubunit interface [polypeptide binding]; other site 393127007065 active site 393127007066 zinc binding site [ion binding]; other site 393127007067 Na+ binding site [ion binding]; other site 393127007068 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127007069 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127007070 active site 393127007071 P-loop; other site 393127007072 phosphorylation site [posttranslational modification] 393127007073 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127007074 active site 393127007075 phosphorylation site [posttranslational modification] 393127007076 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127007077 HTH domain; Region: HTH_11; pfam08279 393127007078 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127007079 PRD domain; Region: PRD; pfam00874 393127007080 PRD domain; Region: PRD; pfam00874 393127007081 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127007082 active site 393127007083 P-loop; other site 393127007084 phosphorylation site [posttranslational modification] 393127007085 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 393127007086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127007087 Walker A/P-loop; other site 393127007088 ATP binding site [chemical binding]; other site 393127007089 Q-loop/lid; other site 393127007090 ABC transporter signature motif; other site 393127007091 Walker B; other site 393127007092 D-loop; other site 393127007093 H-loop/switch region; other site 393127007094 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 393127007095 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 393127007096 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 393127007097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127007098 Coenzyme A binding pocket [chemical binding]; other site 393127007099 Transcriptional regulators [Transcription]; Region: GntR; COG1802 393127007100 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 393127007101 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 393127007102 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 393127007103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127007104 DNA-binding site [nucleotide binding]; DNA binding site 393127007105 UTRA domain; Region: UTRA; pfam07702 393127007106 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 393127007107 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 393127007108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127007109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127007110 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 393127007111 putative dimerization interface [polypeptide binding]; other site 393127007112 Predicted membrane protein [Function unknown]; Region: COG2855 393127007113 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 393127007114 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 393127007115 putative metal binding site [ion binding]; other site 393127007116 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 393127007117 homodimer interface [polypeptide binding]; other site 393127007118 chemical substrate binding site [chemical binding]; other site 393127007119 oligomer interface [polypeptide binding]; other site 393127007120 metal binding site [ion binding]; metal-binding site 393127007121 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127007122 catalytic residues [active] 393127007123 flavodoxin; Provisional; Region: PRK09271 393127007124 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 393127007125 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 393127007126 dimer interface [polypeptide binding]; other site 393127007127 putative radical transfer pathway; other site 393127007128 diiron center [ion binding]; other site 393127007129 tyrosyl radical; other site 393127007130 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 393127007131 Class I ribonucleotide reductase; Region: RNR_I; cd01679 393127007132 active site 393127007133 dimer interface [polypeptide binding]; other site 393127007134 catalytic residues [active] 393127007135 effector binding site; other site 393127007136 R2 peptide binding site; other site 393127007137 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 393127007138 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 393127007139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 393127007140 CsbD-like; Region: CsbD; cl17424 393127007141 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127007142 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127007143 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393127007144 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393127007145 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 393127007146 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 393127007147 conserved cys residue [active] 393127007148 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393127007149 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127007150 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127007151 Cupin domain; Region: Cupin_2; cl17218 393127007152 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127007153 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127007154 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127007155 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 393127007156 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127007157 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127007158 ligand binding site [chemical binding]; other site 393127007159 flexible hinge region; other site 393127007160 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 393127007161 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 393127007162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127007163 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 393127007164 dimer interface [polypeptide binding]; other site 393127007165 active site 393127007166 metal binding site [ion binding]; metal-binding site 393127007167 glutathione binding site [chemical binding]; other site 393127007168 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 393127007169 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 393127007170 FMN binding site [chemical binding]; other site 393127007171 substrate binding site [chemical binding]; other site 393127007172 putative catalytic residue [active] 393127007173 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 393127007174 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 393127007175 putative substrate translocation pore; other site 393127007176 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 393127007177 Coenzyme A transferase; Region: CoA_trans; smart00882 393127007178 Coenzyme A transferase; Region: CoA_trans; cl17247 393127007179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127007180 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 393127007181 Walker A motif; other site 393127007182 ATP binding site [chemical binding]; other site 393127007183 Walker B motif; other site 393127007184 arginine finger; other site 393127007185 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 393127007186 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 393127007187 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 393127007188 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 393127007189 metal binding site [ion binding]; metal-binding site 393127007190 active site 393127007191 I-site; other site 393127007192 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 393127007193 classical (c) SDRs; Region: SDR_c; cd05233 393127007194 NAD(P) binding site [chemical binding]; other site 393127007195 active site 393127007196 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127007197 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127007198 Tic20-like protein; Region: Tic20; pfam09685 393127007199 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393127007200 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007201 Collagen binding domain; Region: Collagen_bind; pfam05737 393127007202 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007203 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007204 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007205 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007206 Cna protein B-type domain; Region: Cna_B; pfam05738 393127007207 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007208 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007209 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007210 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127007211 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 393127007212 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 393127007213 active site 393127007214 catalytic site [active] 393127007215 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393127007216 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393127007217 Walker A/P-loop; other site 393127007218 ATP binding site [chemical binding]; other site 393127007219 Q-loop/lid; other site 393127007220 ABC transporter signature motif; other site 393127007221 Walker B; other site 393127007222 D-loop; other site 393127007223 H-loop/switch region; other site 393127007224 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393127007225 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127007226 ABC-ATPase subunit interface; other site 393127007227 dimer interface [polypeptide binding]; other site 393127007228 putative PBP binding regions; other site 393127007229 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 393127007230 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 393127007231 putative ligand binding residues [chemical binding]; other site 393127007232 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393127007233 heme-binding site [chemical binding]; other site 393127007234 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 393127007235 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393127007236 heme-binding site [chemical binding]; other site 393127007237 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393127007238 heme-binding site [chemical binding]; other site 393127007239 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 393127007240 heme uptake protein IsdC; Region: IsdC; TIGR03656 393127007241 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 393127007242 heme-binding site [chemical binding]; other site 393127007243 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 393127007244 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 393127007245 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 393127007246 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 393127007247 active site 393127007248 Zn binding site [ion binding]; other site 393127007249 Competence protein CoiA-like family; Region: CoiA; cl11541 393127007250 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 393127007251 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 393127007252 ArsC family; Region: ArsC; pfam03960 393127007253 putative catalytic residues [active] 393127007254 thiol/disulfide switch; other site 393127007255 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 393127007256 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 393127007257 Walker A/P-loop; other site 393127007258 ATP binding site [chemical binding]; other site 393127007259 Q-loop/lid; other site 393127007260 ABC transporter signature motif; other site 393127007261 Walker B; other site 393127007262 D-loop; other site 393127007263 H-loop/switch region; other site 393127007264 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 393127007265 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 393127007266 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 393127007267 Walker A/P-loop; other site 393127007268 ATP binding site [chemical binding]; other site 393127007269 Q-loop/lid; other site 393127007270 ABC transporter signature motif; other site 393127007271 Walker B; other site 393127007272 D-loop; other site 393127007273 H-loop/switch region; other site 393127007274 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 393127007275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 393127007276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007277 dimer interface [polypeptide binding]; other site 393127007278 conserved gate region; other site 393127007279 putative PBP binding loops; other site 393127007280 ABC-ATPase subunit interface; other site 393127007281 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 393127007282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007283 dimer interface [polypeptide binding]; other site 393127007284 conserved gate region; other site 393127007285 putative PBP binding loops; other site 393127007286 ABC-ATPase subunit interface; other site 393127007287 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393127007288 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393127007289 peptide binding site [polypeptide binding]; other site 393127007290 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 393127007291 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 393127007292 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 393127007293 active site 393127007294 HIGH motif; other site 393127007295 dimer interface [polypeptide binding]; other site 393127007296 KMSKS motif; other site 393127007297 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 393127007298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127007299 MarR family; Region: MarR; pfam01047 393127007300 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 393127007301 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 393127007302 dimer interface [polypeptide binding]; other site 393127007303 active site 393127007304 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 393127007305 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 393127007306 dimer interface [polypeptide binding]; other site 393127007307 active site 393127007308 CoA binding pocket [chemical binding]; other site 393127007309 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127007310 SH3-like domain; Region: SH3_8; pfam13457 393127007311 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 393127007312 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127007313 catalytic core [active] 393127007314 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 393127007315 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 393127007316 Clp amino terminal domain; Region: Clp_N; pfam02861 393127007317 Clp amino terminal domain; Region: Clp_N; pfam02861 393127007318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127007319 Walker A motif; other site 393127007320 ATP binding site [chemical binding]; other site 393127007321 Walker B motif; other site 393127007322 arginine finger; other site 393127007323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127007324 Walker A motif; other site 393127007325 ATP binding site [chemical binding]; other site 393127007326 Walker B motif; other site 393127007327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 393127007328 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 393127007329 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 393127007330 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127007331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007332 active site 393127007333 motif I; other site 393127007334 motif II; other site 393127007335 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393127007336 Predicted acetyltransferase [General function prediction only]; Region: COG3393 393127007337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 393127007338 ferrochelatase; Provisional; Region: PRK12435 393127007339 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 393127007340 C-terminal domain interface [polypeptide binding]; other site 393127007341 active site 393127007342 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 393127007343 active site 393127007344 N-terminal domain interface [polypeptide binding]; other site 393127007345 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 393127007346 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 393127007347 substrate binding site [chemical binding]; other site 393127007348 active site 393127007349 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 393127007350 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 393127007351 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393127007352 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127007353 Walker A/P-loop; other site 393127007354 ATP binding site [chemical binding]; other site 393127007355 Q-loop/lid; other site 393127007356 ABC transporter signature motif; other site 393127007357 Walker B; other site 393127007358 D-loop; other site 393127007359 H-loop/switch region; other site 393127007360 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 393127007361 HIT family signature motif; other site 393127007362 catalytic residue [active] 393127007363 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 393127007364 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 393127007365 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 393127007366 SurA N-terminal domain; Region: SurA_N_3; cl07813 393127007367 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 393127007368 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 393127007369 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 393127007370 generic binding surface II; other site 393127007371 generic binding surface I; other site 393127007372 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127007373 Zn2+ binding site [ion binding]; other site 393127007374 Mg2+ binding site [ion binding]; other site 393127007375 Uncharacterized conserved protein [Function unknown]; Region: COG4717 393127007376 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 393127007377 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 393127007378 active site 393127007379 metal binding site [ion binding]; metal-binding site 393127007380 DNA binding site [nucleotide binding] 393127007381 hypothetical protein; Provisional; Region: PRK13676 393127007382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 393127007383 fumarate hydratase; Reviewed; Region: fumC; PRK00485 393127007384 Class II fumarases; Region: Fumarase_classII; cd01362 393127007385 active site 393127007386 tetramer interface [polypeptide binding]; other site 393127007387 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 393127007388 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127007389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127007390 Walker A/P-loop; other site 393127007391 ATP binding site [chemical binding]; other site 393127007392 Q-loop/lid; other site 393127007393 ABC transporter signature motif; other site 393127007394 Walker B; other site 393127007395 D-loop; other site 393127007396 H-loop/switch region; other site 393127007397 Transglycosylase; Region: Transgly; pfam00912 393127007398 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 393127007399 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 393127007400 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393127007401 Low molecular weight phosphatase family; Region: LMWPc; cl00105 393127007402 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393127007403 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 393127007404 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393127007405 Domain of unknown function DUF21; Region: DUF21; pfam01595 393127007406 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393127007407 Transporter associated domain; Region: CorC_HlyC; smart01091 393127007408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127007409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127007410 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 393127007411 putative dimerization interface [polypeptide binding]; other site 393127007412 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 393127007413 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 393127007414 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 393127007415 active site 393127007416 FMN binding site [chemical binding]; other site 393127007417 substrate binding site [chemical binding]; other site 393127007418 putative catalytic residue [active] 393127007419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127007420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127007421 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 393127007422 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 393127007423 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 393127007424 shikimate binding site; other site 393127007425 NAD(P) binding site [chemical binding]; other site 393127007426 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127007427 putative substrate translocation pore; other site 393127007428 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127007429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127007430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127007431 putative substrate translocation pore; other site 393127007432 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 393127007433 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127007434 Walker A/P-loop; other site 393127007435 ATP binding site [chemical binding]; other site 393127007436 Q-loop/lid; other site 393127007437 ABC transporter signature motif; other site 393127007438 Walker B; other site 393127007439 D-loop; other site 393127007440 H-loop/switch region; other site 393127007441 Predicted transcriptional regulators [Transcription]; Region: COG1725 393127007442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 393127007443 DNA-binding site [nucleotide binding]; DNA binding site 393127007444 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 393127007445 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 393127007446 DNA binding site [nucleotide binding] 393127007447 active site 393127007448 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 393127007449 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 393127007450 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127007451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127007452 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 393127007453 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 393127007454 active site 393127007455 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 393127007456 putative dimer interface [polypeptide binding]; other site 393127007457 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127007458 ligand binding site [chemical binding]; other site 393127007459 Zn binding site [ion binding]; other site 393127007460 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 393127007461 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 393127007462 active site 393127007463 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127007464 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127007465 active site 393127007466 catalytic tetrad [active] 393127007467 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 393127007468 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 393127007469 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393127007470 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393127007471 substrate binding pocket [chemical binding]; other site 393127007472 membrane-bound complex binding site; other site 393127007473 hinge residues; other site 393127007474 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393127007475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007476 dimer interface [polypeptide binding]; other site 393127007477 conserved gate region; other site 393127007478 putative PBP binding loops; other site 393127007479 ABC-ATPase subunit interface; other site 393127007480 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393127007481 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393127007482 Walker A/P-loop; other site 393127007483 ATP binding site [chemical binding]; other site 393127007484 Q-loop/lid; other site 393127007485 ABC transporter signature motif; other site 393127007486 Walker B; other site 393127007487 D-loop; other site 393127007488 H-loop/switch region; other site 393127007489 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127007490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127007491 homodimer interface [polypeptide binding]; other site 393127007492 catalytic residue [active] 393127007493 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 393127007494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393127007495 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007496 motif II; other site 393127007497 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 393127007498 intracellular protease, PfpI family; Region: PfpI; TIGR01382 393127007499 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 393127007500 proposed catalytic triad [active] 393127007501 conserved cys residue [active] 393127007502 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 393127007503 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127007504 methionine cluster; other site 393127007505 active site 393127007506 phosphorylation site [posttranslational modification] 393127007507 metal binding site [ion binding]; metal-binding site 393127007508 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 393127007509 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127007510 Coenzyme A binding pocket [chemical binding]; other site 393127007511 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 393127007512 esterase; Provisional; Region: PRK10566 393127007513 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 393127007514 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127007515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 393127007516 motif II; other site 393127007517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007518 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393127007519 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127007520 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127007521 hypothetical protein; Provisional; Region: PRK13673 393127007522 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 393127007523 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 393127007524 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 393127007525 Part of AAA domain; Region: AAA_19; pfam13245 393127007526 Family description; Region: UvrD_C_2; pfam13538 393127007527 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 393127007528 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 393127007529 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 393127007530 IDEAL domain; Region: IDEAL; pfam08858 393127007531 ComK protein; Region: ComK; cl11560 393127007532 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 393127007533 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127007534 non-specific DNA binding site [nucleotide binding]; other site 393127007535 salt bridge; other site 393127007536 sequence-specific DNA binding site [nucleotide binding]; other site 393127007537 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 393127007538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127007539 active site 393127007540 phosphorylation site [posttranslational modification] 393127007541 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127007542 active site 393127007543 P-loop; other site 393127007544 phosphorylation site [posttranslational modification] 393127007545 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127007546 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 393127007547 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 393127007548 putative substrate binding site [chemical binding]; other site 393127007549 putative ATP binding site [chemical binding]; other site 393127007550 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127007551 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 393127007552 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127007553 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 393127007554 trimer interface [polypeptide binding]; other site 393127007555 active site 393127007556 G bulge; other site 393127007557 Uncharacterized conserved protein [Function unknown]; Region: COG1683 393127007558 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 393127007559 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 393127007560 non-specific DNA interactions [nucleotide binding]; other site 393127007561 DNA binding site [nucleotide binding] 393127007562 sequence specific DNA binding site [nucleotide binding]; other site 393127007563 putative cAMP binding site [chemical binding]; other site 393127007564 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 393127007565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 393127007566 substrate binding site [chemical binding]; other site 393127007567 ATP binding site [chemical binding]; other site 393127007568 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 393127007569 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 393127007570 RNA binding surface [nucleotide binding]; other site 393127007571 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 393127007572 active site 393127007573 uracil binding [chemical binding]; other site 393127007574 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 393127007575 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 393127007576 active site 393127007577 non-prolyl cis peptide bond; other site 393127007578 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 393127007579 catalytic residues [active] 393127007580 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 393127007581 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 393127007582 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 393127007583 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 393127007584 Walker A/P-loop; other site 393127007585 ATP binding site [chemical binding]; other site 393127007586 Q-loop/lid; other site 393127007587 ABC transporter signature motif; other site 393127007588 Walker B; other site 393127007589 D-loop; other site 393127007590 H-loop/switch region; other site 393127007591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393127007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007593 dimer interface [polypeptide binding]; other site 393127007594 conserved gate region; other site 393127007595 putative PBP binding loops; other site 393127007596 ABC-ATPase subunit interface; other site 393127007597 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 393127007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007599 dimer interface [polypeptide binding]; other site 393127007600 conserved gate region; other site 393127007601 putative PBP binding loops; other site 393127007602 ABC-ATPase subunit interface; other site 393127007603 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 393127007604 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 393127007605 substrate binding pocket [chemical binding]; other site 393127007606 membrane-bound complex binding site; other site 393127007607 hinge residues; other site 393127007608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127007609 Coenzyme A binding pocket [chemical binding]; other site 393127007610 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 393127007611 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 393127007612 Transcriptional regulator [Transcription]; Region: LysR; COG0583 393127007613 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 393127007614 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 393127007615 dimerization interface [polypeptide binding]; other site 393127007616 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 393127007617 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 393127007618 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 393127007619 active site 393127007620 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127007621 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127007622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127007623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127007624 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 393127007625 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393127007626 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393127007627 active site 393127007628 trimer interface [polypeptide binding]; other site 393127007629 allosteric site; other site 393127007630 active site lid [active] 393127007631 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393127007632 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127007633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007634 active site 393127007635 motif I; other site 393127007636 motif II; other site 393127007637 Predicted membrane protein [Function unknown]; Region: COG1511 393127007638 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 393127007639 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 393127007640 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 393127007641 Predicted transcriptional regulator [Transcription]; Region: COG1959 393127007642 Transcriptional regulator; Region: Rrf2; pfam02082 393127007643 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 393127007644 L-tyrosine decarboxylase; Provisional; Region: PRK13520 393127007645 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393127007646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127007647 catalytic residue [active] 393127007648 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 393127007649 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127007650 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 393127007651 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 393127007652 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 393127007653 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 393127007654 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 393127007655 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 393127007656 active site 393127007657 dimer interface [polypeptide binding]; other site 393127007658 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 393127007659 dimer interface [polypeptide binding]; other site 393127007660 active site 393127007661 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 393127007662 nudix motif; other site 393127007663 general stress protein 13; Validated; Region: PRK08059 393127007664 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 393127007665 RNA binding site [nucleotide binding]; other site 393127007666 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 393127007667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 393127007668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127007669 homodimer interface [polypeptide binding]; other site 393127007670 catalytic residue [active] 393127007671 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 393127007672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127007673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127007674 Walker A/P-loop; other site 393127007675 ATP binding site [chemical binding]; other site 393127007676 Q-loop/lid; other site 393127007677 ABC transporter signature motif; other site 393127007678 Walker B; other site 393127007679 D-loop; other site 393127007680 H-loop/switch region; other site 393127007681 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127007682 active site 393127007683 P-loop; other site 393127007684 phosphorylation site [posttranslational modification] 393127007685 aspartate kinase; Reviewed; Region: PRK09034 393127007686 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 393127007687 putative catalytic residues [active] 393127007688 putative nucleotide binding site [chemical binding]; other site 393127007689 putative aspartate binding site [chemical binding]; other site 393127007690 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 393127007691 allosteric regulatory residue; other site 393127007692 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 393127007693 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 393127007694 active site 393127007695 drug efflux system protein MdtG; Provisional; Region: PRK09874 393127007696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127007697 putative substrate translocation pore; other site 393127007698 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 393127007699 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393127007700 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 393127007701 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 393127007702 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 393127007703 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 393127007704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 393127007705 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 393127007706 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 393127007707 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 393127007708 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 393127007709 CoenzymeA binding site [chemical binding]; other site 393127007710 subunit interaction site [polypeptide binding]; other site 393127007711 PHB binding site; other site 393127007712 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 393127007713 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 393127007714 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 393127007715 Cl- selectivity filter; other site 393127007716 Cl- binding residues [ion binding]; other site 393127007717 pore gating glutamate residue; other site 393127007718 dimer interface [polypeptide binding]; other site 393127007719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 393127007720 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 393127007721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127007722 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 393127007723 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127007724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127007725 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 393127007726 NADH(P)-binding; Region: NAD_binding_10; pfam13460 393127007727 NAD(P) binding site [chemical binding]; other site 393127007728 putative active site [active] 393127007729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 393127007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 393127007731 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127007732 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007733 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007734 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007735 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007736 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007737 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127007738 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 393127007739 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 393127007740 tetramer interfaces [polypeptide binding]; other site 393127007741 binuclear metal-binding site [ion binding]; other site 393127007742 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393127007743 Domain of unknown function DUF21; Region: DUF21; pfam01595 393127007744 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393127007745 Transporter associated domain; Region: CorC_HlyC; smart01091 393127007746 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 393127007747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127007748 Coenzyme A binding pocket [chemical binding]; other site 393127007749 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 393127007750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007751 active site 393127007752 motif I; other site 393127007753 motif II; other site 393127007754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127007755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 393127007756 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 393127007757 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 393127007758 active site 393127007759 metal binding site [ion binding]; metal-binding site 393127007760 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 393127007761 Predicted permeases [General function prediction only]; Region: COG0730 393127007762 Predicted membrane protein [Function unknown]; Region: COG4272 393127007763 Uncharacterized conserved protein [Function unknown]; Region: COG1801 393127007764 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 393127007765 FeS assembly protein SufB; Region: sufB; TIGR01980 393127007766 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 393127007767 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 393127007768 trimerization site [polypeptide binding]; other site 393127007769 active site 393127007770 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 393127007771 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 393127007772 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127007773 catalytic residue [active] 393127007774 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 393127007775 FeS assembly protein SufD; Region: sufD; TIGR01981 393127007776 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 393127007777 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 393127007778 Walker A/P-loop; other site 393127007779 ATP binding site [chemical binding]; other site 393127007780 Q-loop/lid; other site 393127007781 ABC transporter signature motif; other site 393127007782 Walker B; other site 393127007783 D-loop; other site 393127007784 H-loop/switch region; other site 393127007785 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 393127007786 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 393127007787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127007788 ABC-ATPase subunit interface; other site 393127007789 putative PBP binding loops; other site 393127007790 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 393127007791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127007792 ABC transporter signature motif; other site 393127007793 Walker B; other site 393127007794 D-loop; other site 393127007795 H-loop/switch region; other site 393127007796 NIL domain; Region: NIL; pfam09383 393127007797 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127007798 dimer interface [polypeptide binding]; other site 393127007799 phosphorylation site [posttranslational modification] 393127007800 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127007801 ATP binding site [chemical binding]; other site 393127007802 Mg2+ binding site [ion binding]; other site 393127007803 G-X-G motif; other site 393127007804 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127007805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127007806 active site 393127007807 phosphorylation site [posttranslational modification] 393127007808 intermolecular recognition site; other site 393127007809 dimerization interface [polypeptide binding]; other site 393127007810 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127007811 DNA binding site [nucleotide binding] 393127007812 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393127007813 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 393127007814 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127007815 catalytic residues [active] 393127007816 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 393127007817 lipoyl attachment site [posttranslational modification]; other site 393127007818 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 393127007819 ArsC family; Region: ArsC; pfam03960 393127007820 putative ArsC-like catalytic residues; other site 393127007821 putative TRX-like catalytic residues [active] 393127007822 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 393127007823 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 393127007824 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 393127007825 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 393127007826 Walker A/P-loop; other site 393127007827 ATP binding site [chemical binding]; other site 393127007828 Q-loop/lid; other site 393127007829 ABC transporter signature motif; other site 393127007830 Walker B; other site 393127007831 D-loop; other site 393127007832 H-loop/switch region; other site 393127007833 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 393127007834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 393127007835 ABC-ATPase subunit interface; other site 393127007836 dimer interface [polypeptide binding]; other site 393127007837 putative PBP binding regions; other site 393127007838 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 393127007839 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 393127007840 intersubunit interface [polypeptide binding]; other site 393127007841 Predicted esterase [General function prediction only]; Region: COG0627 393127007842 S-formylglutathione hydrolase; Region: PLN02442 393127007843 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 393127007844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127007845 catalytic residue [active] 393127007846 SdpI/YhfL protein family; Region: SdpI; pfam13630 393127007847 CAT RNA binding domain; Region: CAT_RBD; smart01061 393127007848 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393127007849 PRD domain; Region: PRD; pfam00874 393127007850 PRD domain; Region: PRD; pfam00874 393127007851 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 393127007852 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 393127007853 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 393127007854 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 393127007855 Predicted transcriptional regulator [Transcription]; Region: COG2378 393127007856 HTH domain; Region: HTH_11; pfam08279 393127007857 WYL domain; Region: WYL; pfam13280 393127007858 Uncharacterized conserved protein [Function unknown]; Region: COG1434 393127007859 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 393127007860 putative active site [active] 393127007861 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393127007862 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 393127007863 active site 393127007864 catalytic site [active] 393127007865 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393127007866 putative metal binding site [ion binding]; other site 393127007867 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393127007868 putative metal binding site [ion binding]; other site 393127007869 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127007870 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 393127007871 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 393127007872 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 393127007873 active site 393127007874 catalytic site [active] 393127007875 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 393127007876 putative metal binding site [ion binding]; other site 393127007877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127007878 non-specific DNA binding site [nucleotide binding]; other site 393127007879 salt bridge; other site 393127007880 sequence-specific DNA binding site [nucleotide binding]; other site 393127007881 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 393127007882 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 393127007883 SmpB-tmRNA interface; other site 393127007884 ribonuclease R; Region: RNase_R; TIGR02063 393127007885 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 393127007886 RNB domain; Region: RNB; pfam00773 393127007887 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 393127007888 RNA binding site [nucleotide binding]; other site 393127007889 Esterase/lipase [General function prediction only]; Region: COG1647 393127007890 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127007891 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 393127007892 Preprotein translocase SecG subunit; Region: SecG; cl09123 393127007893 Esterase/lipase [General function prediction only]; Region: COG1647 393127007894 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 393127007895 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 393127007896 PGAP1-like protein; Region: PGAP1; pfam07819 393127007897 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 393127007898 enolase; Provisional; Region: eno; PRK00077 393127007899 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 393127007900 dimer interface [polypeptide binding]; other site 393127007901 metal binding site [ion binding]; metal-binding site 393127007902 substrate binding pocket [chemical binding]; other site 393127007903 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 393127007904 phosphoglyceromutase; Provisional; Region: PRK05434 393127007905 triosephosphate isomerase; Provisional; Region: PRK14567 393127007906 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 393127007907 substrate binding site [chemical binding]; other site 393127007908 dimer interface [polypeptide binding]; other site 393127007909 catalytic triad [active] 393127007910 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 393127007911 Phosphoglycerate kinase; Region: PGK; pfam00162 393127007912 substrate binding site [chemical binding]; other site 393127007913 hinge regions; other site 393127007914 ADP binding site [chemical binding]; other site 393127007915 catalytic site [active] 393127007916 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 393127007917 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 393127007918 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 393127007919 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 393127007920 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 393127007921 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 393127007922 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 393127007923 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 393127007924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127007925 DNA binding site [nucleotide binding] 393127007926 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 393127007927 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 393127007928 active site 393127007929 dimer interface [polypeptide binding]; other site 393127007930 MMPL family; Region: MMPL; pfam03176 393127007931 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 393127007932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127007933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127007934 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 393127007935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 393127007936 Chitin binding domain; Region: Chitin_bind_3; pfam03067 393127007937 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 393127007938 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 393127007939 Interdomain contacts; other site 393127007940 Cytokine receptor motif; other site 393127007941 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393127007942 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393127007943 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 393127007944 aromatic chitin/cellulose binding site residues [chemical binding]; other site 393127007945 Clp protease; Region: CLP_protease; pfam00574 393127007946 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 393127007947 oligomer interface [polypeptide binding]; other site 393127007948 active site residues [active] 393127007949 amino acid transporter; Region: 2A0306; TIGR00909 393127007950 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 393127007951 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 393127007952 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127007953 Substrate binding site [chemical binding]; other site 393127007954 Leucine rich repeat; Region: LRR_8; pfam13855 393127007955 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127007956 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 393127007957 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 393127007958 active site 393127007959 FMN binding site [chemical binding]; other site 393127007960 substrate binding site [chemical binding]; other site 393127007961 homotetramer interface [polypeptide binding]; other site 393127007962 catalytic residue [active] 393127007963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 393127007964 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 393127007965 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 393127007966 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 393127007967 phosphate binding site [ion binding]; other site 393127007968 putative substrate binding pocket [chemical binding]; other site 393127007969 dimer interface [polypeptide binding]; other site 393127007970 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 393127007971 AAA domain; Region: AAA_18; pfam13238 393127007972 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 393127007973 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 393127007974 active site 393127007975 substrate binding site [chemical binding]; other site 393127007976 metal binding site [ion binding]; metal-binding site 393127007977 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 393127007978 active site 393127007979 catalytic residues [active] 393127007980 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 393127007981 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 393127007982 NAD binding site [chemical binding]; other site 393127007983 homodimer interface [polypeptide binding]; other site 393127007984 active site 393127007985 substrate binding site [chemical binding]; other site 393127007986 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 393127007987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 393127007988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127007989 TPR repeat; Region: TPR_11; pfam13414 393127007990 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127007991 binding surface 393127007992 TPR motif; other site 393127007993 Tetratricopeptide repeat; Region: TPR_12; pfam13424 393127007994 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 393127007995 binding surface 393127007996 TPR motif; other site 393127007997 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 393127007998 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 393127007999 putative trimer interface [polypeptide binding]; other site 393127008000 putative CoA binding site [chemical binding]; other site 393127008001 pyrophosphatase PpaX; Provisional; Region: PRK13288 393127008002 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393127008003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127008004 motif II; other site 393127008005 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 393127008006 HPr kinase/phosphorylase; Provisional; Region: PRK05428 393127008007 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 393127008008 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 393127008009 Hpr binding site; other site 393127008010 active site 393127008011 homohexamer subunit interaction site [polypeptide binding]; other site 393127008012 Predicted membrane protein [Function unknown]; Region: COG1950 393127008013 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 393127008014 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 393127008015 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393127008016 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127008017 Uncharacterized conserved protein [Function unknown]; Region: COG3595 393127008018 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 393127008019 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 393127008020 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393127008021 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 393127008022 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 393127008023 excinuclease ABC subunit B; Provisional; Region: PRK05298 393127008024 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127008025 ATP binding site [chemical binding]; other site 393127008026 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127008027 nucleotide binding region [chemical binding]; other site 393127008028 ATP-binding site [chemical binding]; other site 393127008029 Ultra-violet resistance protein B; Region: UvrB; pfam12344 393127008030 UvrB/uvrC motif; Region: UVR; pfam02151 393127008031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 393127008032 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 393127008033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 393127008034 dimerization interface [polypeptide binding]; other site 393127008035 putative DNA binding site [nucleotide binding]; other site 393127008036 putative Zn2+ binding site [ion binding]; other site 393127008037 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 393127008038 PhoU domain; Region: PhoU; pfam01895 393127008039 PhoU domain; Region: PhoU; pfam01895 393127008040 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 393127008041 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 393127008042 Walker A/P-loop; other site 393127008043 ATP binding site [chemical binding]; other site 393127008044 Q-loop/lid; other site 393127008045 ABC transporter signature motif; other site 393127008046 Walker B; other site 393127008047 D-loop; other site 393127008048 H-loop/switch region; other site 393127008049 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 393127008050 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 393127008051 Walker A/P-loop; other site 393127008052 ATP binding site [chemical binding]; other site 393127008053 Q-loop/lid; other site 393127008054 ABC transporter signature motif; other site 393127008055 Walker B; other site 393127008056 D-loop; other site 393127008057 H-loop/switch region; other site 393127008058 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 393127008059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127008060 dimer interface [polypeptide binding]; other site 393127008061 conserved gate region; other site 393127008062 putative PBP binding loops; other site 393127008063 ABC-ATPase subunit interface; other site 393127008064 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 393127008065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127008066 dimer interface [polypeptide binding]; other site 393127008067 conserved gate region; other site 393127008068 putative PBP binding loops; other site 393127008069 ABC-ATPase subunit interface; other site 393127008070 PBP superfamily domain; Region: PBP_like_2; cl17296 393127008071 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 393127008072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 393127008073 HAMP domain; Region: HAMP; pfam00672 393127008074 dimerization interface [polypeptide binding]; other site 393127008075 PAS domain; Region: PAS; smart00091 393127008076 putative active site [active] 393127008077 heme pocket [chemical binding]; other site 393127008078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127008079 dimer interface [polypeptide binding]; other site 393127008080 phosphorylation site [posttranslational modification] 393127008081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127008082 ATP binding site [chemical binding]; other site 393127008083 Mg2+ binding site [ion binding]; other site 393127008084 G-X-G motif; other site 393127008085 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127008086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127008087 active site 393127008088 phosphorylation site [posttranslational modification] 393127008089 intermolecular recognition site; other site 393127008090 dimerization interface [polypeptide binding]; other site 393127008091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127008092 DNA binding site [nucleotide binding] 393127008093 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 393127008094 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 393127008095 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 393127008096 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 393127008097 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 393127008098 putative active site [active] 393127008099 catalytic site [active] 393127008100 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 393127008101 putative active site [active] 393127008102 catalytic site [active] 393127008103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 393127008104 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 393127008105 Peptidase family M23; Region: Peptidase_M23; pfam01551 393127008106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 393127008107 NlpC/P60 family; Region: NLPC_P60; pfam00877 393127008108 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 393127008109 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 393127008110 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 393127008111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127008112 Walker A/P-loop; other site 393127008113 ATP binding site [chemical binding]; other site 393127008114 Q-loop/lid; other site 393127008115 ABC transporter signature motif; other site 393127008116 Walker B; other site 393127008117 D-loop; other site 393127008118 H-loop/switch region; other site 393127008119 Uncharacterized conserved protein [Function unknown]; Region: COG1284 393127008120 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127008121 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 393127008122 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 393127008123 peptide chain release factor 2; Validated; Region: prfB; PRK00578 393127008124 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393127008125 RF-1 domain; Region: RF-1; pfam00472 393127008126 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 393127008127 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 393127008128 nucleotide binding region [chemical binding]; other site 393127008129 helicase superfamily c-terminal domain; Region: HELICc; smart00490 393127008130 ATP-binding site [chemical binding]; other site 393127008131 SEC-C motif; Region: SEC-C; pfam02810 393127008132 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 393127008133 30S subunit binding site; other site 393127008134 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 393127008135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127008136 active site 393127008137 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 393127008138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127008139 ATP binding site [chemical binding]; other site 393127008140 putative Mg++ binding site [ion binding]; other site 393127008141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127008142 nucleotide binding region [chemical binding]; other site 393127008143 ATP-binding site [chemical binding]; other site 393127008144 EDD domain protein, DegV family; Region: DegV; TIGR00762 393127008145 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 393127008146 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 393127008147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127008148 active site 393127008149 phosphorylation site [posttranslational modification] 393127008150 intermolecular recognition site; other site 393127008151 dimerization interface [polypeptide binding]; other site 393127008152 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 393127008153 DNA binding residues [nucleotide binding] 393127008154 dimerization interface [polypeptide binding]; other site 393127008155 Uncharacterized conserved protein [Function unknown]; Region: COG1739 393127008156 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 393127008157 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 393127008158 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 393127008159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 393127008160 Transcriptional regulator [Transcription]; Region: LytR; COG1316 393127008161 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 393127008162 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 393127008163 Mg++ binding site [ion binding]; other site 393127008164 putative catalytic motif [active] 393127008165 substrate binding site [chemical binding]; other site 393127008166 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 393127008167 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 393127008168 active site 393127008169 octamer interface [polypeptide binding]; other site 393127008170 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 393127008171 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 393127008172 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008174 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 393127008175 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 393127008176 dimer interface [polypeptide binding]; other site 393127008177 ssDNA binding site [nucleotide binding]; other site 393127008178 tetramer (dimer of dimers) interface [polypeptide binding]; other site 393127008179 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 393127008180 rod shape-determining protein Mbl; Provisional; Region: PRK13928 393127008181 MreB and similar proteins; Region: MreB_like; cd10225 393127008182 nucleotide binding site [chemical binding]; other site 393127008183 Mg binding site [ion binding]; other site 393127008184 putative protofilament interaction site [polypeptide binding]; other site 393127008185 RodZ interaction site [polypeptide binding]; other site 393127008186 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 393127008187 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 393127008188 hinge; other site 393127008189 active site 393127008190 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 393127008191 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 393127008192 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 393127008193 gamma subunit interface [polypeptide binding]; other site 393127008194 epsilon subunit interface [polypeptide binding]; other site 393127008195 LBP interface [polypeptide binding]; other site 393127008196 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 393127008197 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393127008198 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 393127008199 alpha subunit interaction interface [polypeptide binding]; other site 393127008200 Walker A motif; other site 393127008201 ATP binding site [chemical binding]; other site 393127008202 Walker B motif; other site 393127008203 inhibitor binding site; inhibition site 393127008204 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393127008205 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 393127008206 core domain interface [polypeptide binding]; other site 393127008207 delta subunit interface [polypeptide binding]; other site 393127008208 epsilon subunit interface [polypeptide binding]; other site 393127008209 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 393127008210 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 393127008211 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 393127008212 beta subunit interaction interface [polypeptide binding]; other site 393127008213 Walker A motif; other site 393127008214 ATP binding site [chemical binding]; other site 393127008215 Walker B motif; other site 393127008216 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 393127008217 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 393127008218 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 393127008219 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 393127008220 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 393127008221 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 393127008222 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 393127008223 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 393127008224 ATP synthase I chain; Region: ATP_synt_I; pfam03899 393127008225 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 393127008226 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 393127008227 active site 393127008228 homodimer interface [polypeptide binding]; other site 393127008229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 393127008230 active site 393127008231 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 393127008232 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 393127008233 dimer interface [polypeptide binding]; other site 393127008234 active site 393127008235 glycine-pyridoxal phosphate binding site [chemical binding]; other site 393127008236 folate binding site [chemical binding]; other site 393127008237 Low molecular weight phosphatase family; Region: LMWPc; cd00115 393127008238 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 393127008239 active site 393127008240 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 393127008241 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 393127008242 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 393127008243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 393127008244 S-adenosylmethionine binding site [chemical binding]; other site 393127008245 peptide chain release factor 1; Validated; Region: prfA; PRK00591 393127008246 This domain is found in peptide chain release factors; Region: PCRF; smart00937 393127008247 RF-1 domain; Region: RF-1; pfam00472 393127008248 thymidine kinase; Provisional; Region: PRK04296 393127008249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 393127008250 ATP binding site [chemical binding]; other site 393127008251 Walker A motif; other site 393127008252 Walker B motif; other site 393127008253 homoserine kinase; Provisional; Region: PRK01212 393127008254 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 393127008255 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 393127008256 threonine synthase; Reviewed; Region: PRK06721 393127008257 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 393127008258 homodimer interface [polypeptide binding]; other site 393127008259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127008260 catalytic residue [active] 393127008261 homoserine dehydrogenase; Provisional; Region: PRK06349 393127008262 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 393127008263 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 393127008264 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 393127008265 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 393127008266 Predicted membrane protein [Function unknown]; Region: COG2246 393127008267 GtrA-like protein; Region: GtrA; pfam04138 393127008268 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 393127008269 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 393127008270 Ligand binding site; other site 393127008271 Putative Catalytic site; other site 393127008272 DXD motif; other site 393127008273 transcription termination factor Rho; Provisional; Region: rho; PRK09376 393127008274 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 393127008275 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 393127008276 RNA binding site [nucleotide binding]; other site 393127008277 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 393127008278 multimer interface [polypeptide binding]; other site 393127008279 Walker A motif; other site 393127008280 ATP binding site [chemical binding]; other site 393127008281 Walker B motif; other site 393127008282 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 393127008283 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 393127008284 hinge; other site 393127008285 active site 393127008286 Predicted integral membrane protein [Function unknown]; Region: COG0392 393127008287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393127008288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 393127008289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 393127008290 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 393127008291 putative ADP-binding pocket [chemical binding]; other site 393127008292 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 393127008293 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 393127008294 intersubunit interface [polypeptide binding]; other site 393127008295 active site 393127008296 zinc binding site [ion binding]; other site 393127008297 Na+ binding site [ion binding]; other site 393127008298 putative lipid kinase; Reviewed; Region: PRK13055 393127008299 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 393127008300 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 393127008301 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 393127008302 amidase catalytic site [active] 393127008303 Zn binding residues [ion binding]; other site 393127008304 substrate binding site [chemical binding]; other site 393127008305 SH3-like domain; Region: SH3_8; pfam13457 393127008306 SH3-like domain; Region: SH3_8; pfam13457 393127008307 SH3-like domain; Region: SH3_8; pfam13457 393127008308 SH3-like domain; Region: SH3_8; pfam13457 393127008309 CTP synthetase; Validated; Region: pyrG; PRK05380 393127008310 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 393127008311 Catalytic site [active] 393127008312 active site 393127008313 UTP binding site [chemical binding]; other site 393127008314 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 393127008315 active site 393127008316 putative oxyanion hole; other site 393127008317 catalytic triad [active] 393127008318 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 393127008319 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 393127008320 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 393127008321 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 393127008322 active site 393127008323 HIGH motif; other site 393127008324 KMSK motif region; other site 393127008325 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 393127008326 tRNA binding surface [nucleotide binding]; other site 393127008327 anticodon binding site; other site 393127008328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 393127008329 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 393127008330 Peptidase family M50; Region: Peptidase_M50; pfam02163 393127008331 active site 393127008332 putative substrate binding region [chemical binding]; other site 393127008333 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 393127008334 active site 1 [active] 393127008335 dimer interface [polypeptide binding]; other site 393127008336 hexamer interface [polypeptide binding]; other site 393127008337 active site 2 [active] 393127008338 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 393127008339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127008340 Zn2+ binding site [ion binding]; other site 393127008341 Mg2+ binding site [ion binding]; other site 393127008342 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 393127008343 conserved hypothetical protein TIGR01655; Region: yxeA_fam 393127008344 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 393127008345 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 393127008346 peptide binding site [polypeptide binding]; other site 393127008347 Predicted integral membrane protein [Function unknown]; Region: COG5658 393127008348 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 393127008349 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 393127008350 catalytic triad [active] 393127008351 metal binding site [ion binding]; metal-binding site 393127008352 conserved cis-peptide bond; other site 393127008353 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 393127008354 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 393127008355 folate binding site [chemical binding]; other site 393127008356 NADP+ binding site [chemical binding]; other site 393127008357 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 393127008358 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 393127008359 putative NAD(P) binding site [chemical binding]; other site 393127008360 dimer interface [polypeptide binding]; other site 393127008361 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 393127008362 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 393127008363 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 393127008364 Collagen binding domain; Region: Collagen_bind; pfam05737 393127008365 Collagen binding domain; Region: Collagen_bind; pfam05737 393127008366 Collagen binding domain; Region: Collagen_bind; pfam05737 393127008367 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008368 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008369 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008370 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008371 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008372 Cna protein B-type domain; Region: Cna_B; pfam05738 393127008373 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127008374 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127008375 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127008376 active site 393127008377 motif I; other site 393127008378 motif II; other site 393127008379 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 393127008380 Uncharacterized conserved protein [Function unknown]; Region: COG1359 393127008381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 393127008382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 393127008383 Walker A/P-loop; other site 393127008384 ATP binding site [chemical binding]; other site 393127008385 Q-loop/lid; other site 393127008386 ABC transporter signature motif; other site 393127008387 Walker B; other site 393127008388 D-loop; other site 393127008389 H-loop/switch region; other site 393127008390 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 393127008391 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 393127008392 FtsX-like permease family; Region: FtsX; pfam02687 393127008393 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 393127008394 dimerization interface [polypeptide binding]; other site 393127008395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127008396 dimer interface [polypeptide binding]; other site 393127008397 phosphorylation site [posttranslational modification] 393127008398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127008399 ATP binding site [chemical binding]; other site 393127008400 Mg2+ binding site [ion binding]; other site 393127008401 G-X-G motif; other site 393127008402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127008403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127008404 active site 393127008405 phosphorylation site [posttranslational modification] 393127008406 intermolecular recognition site; other site 393127008407 dimerization interface [polypeptide binding]; other site 393127008408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127008409 DNA binding site [nucleotide binding] 393127008410 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 393127008411 Uncharacterized conserved protein [Function unknown]; Region: COG2427 393127008412 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 393127008413 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 393127008414 catalytic loop [active] 393127008415 iron binding site [ion binding]; other site 393127008416 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 393127008417 4Fe-4S binding domain; Region: Fer4; pfam00037 393127008418 4Fe-4S binding domain; Region: Fer4; pfam00037 393127008419 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 393127008420 [4Fe-4S] binding site [ion binding]; other site 393127008421 molybdopterin cofactor binding site; other site 393127008422 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 393127008423 molybdopterin cofactor binding site; other site 393127008424 Uncharacterized conserved protein [Function unknown]; Region: COG1912 393127008425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127008426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127008427 putative substrate translocation pore; other site 393127008428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127008429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127008430 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 393127008431 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 393127008432 Walker A motif; other site 393127008433 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127008434 SH3-like domain; Region: SH3_8; pfam13457 393127008435 SH3-like domain; Region: SH3_8; pfam13457 393127008436 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127008437 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127008438 active site 393127008439 catalytic tetrad [active] 393127008440 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127008441 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127008442 DNA binding residues [nucleotide binding] 393127008443 putative dimer interface [polypeptide binding]; other site 393127008444 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 393127008445 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 393127008446 23S rRNA interface [nucleotide binding]; other site 393127008447 L3 interface [polypeptide binding]; other site 393127008448 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 393127008449 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 393127008450 dimerization interface 3.5A [polypeptide binding]; other site 393127008451 active site 393127008452 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 393127008453 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 393127008454 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393127008455 Walker A/P-loop; other site 393127008456 ATP binding site [chemical binding]; other site 393127008457 Q-loop/lid; other site 393127008458 ABC transporter signature motif; other site 393127008459 Walker B; other site 393127008460 D-loop; other site 393127008461 H-loop/switch region; other site 393127008462 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 393127008463 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 393127008464 Walker A/P-loop; other site 393127008465 ATP binding site [chemical binding]; other site 393127008466 Q-loop/lid; other site 393127008467 ABC transporter signature motif; other site 393127008468 Walker B; other site 393127008469 D-loop; other site 393127008470 H-loop/switch region; other site 393127008471 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 393127008472 MgtC family; Region: MgtC; pfam02308 393127008473 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 393127008474 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 393127008475 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 393127008476 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 393127008477 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 393127008478 alphaNTD - beta interaction site [polypeptide binding]; other site 393127008479 alphaNTD homodimer interface [polypeptide binding]; other site 393127008480 alphaNTD - beta' interaction site [polypeptide binding]; other site 393127008481 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 393127008482 30S ribosomal protein S11; Validated; Region: PRK05309 393127008483 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 393127008484 30S ribosomal protein S13; Region: bact_S13; TIGR03631 393127008485 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 393127008486 rRNA binding site [nucleotide binding]; other site 393127008487 predicted 30S ribosome binding site; other site 393127008488 adenylate kinase; Reviewed; Region: adk; PRK00279 393127008489 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 393127008490 AMP-binding site [chemical binding]; other site 393127008491 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 393127008492 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 393127008493 SecY translocase; Region: SecY; pfam00344 393127008494 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 393127008495 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 393127008496 23S rRNA binding site [nucleotide binding]; other site 393127008497 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 393127008498 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 393127008499 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 393127008500 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 393127008501 5S rRNA interface [nucleotide binding]; other site 393127008502 L27 interface [polypeptide binding]; other site 393127008503 23S rRNA interface [nucleotide binding]; other site 393127008504 L5 interface [polypeptide binding]; other site 393127008505 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 393127008506 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393127008507 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 393127008508 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 393127008509 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 393127008510 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 393127008511 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 393127008512 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 393127008513 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 393127008514 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 393127008515 RNA binding site [nucleotide binding]; other site 393127008516 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 393127008517 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 393127008518 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 393127008519 23S rRNA interface [nucleotide binding]; other site 393127008520 putative translocon interaction site; other site 393127008521 signal recognition particle (SRP54) interaction site; other site 393127008522 L23 interface [polypeptide binding]; other site 393127008523 trigger factor interaction site; other site 393127008524 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 393127008525 23S rRNA interface [nucleotide binding]; other site 393127008526 5S rRNA interface [nucleotide binding]; other site 393127008527 putative antibiotic binding site [chemical binding]; other site 393127008528 L25 interface [polypeptide binding]; other site 393127008529 L27 interface [polypeptide binding]; other site 393127008530 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 393127008531 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 393127008532 G-X-X-G motif; other site 393127008533 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 393127008534 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 393127008535 putative translocon binding site; other site 393127008536 protein-rRNA interface [nucleotide binding]; other site 393127008537 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 393127008538 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 393127008539 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 393127008540 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 393127008541 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 393127008542 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 393127008543 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 393127008544 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 393127008545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 393127008546 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 393127008547 UbiA prenyltransferase family; Region: UbiA; pfam01040 393127008548 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 393127008549 ApbE family; Region: ApbE; pfam02424 393127008550 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 393127008551 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 393127008552 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 393127008553 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 393127008554 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 393127008555 Predicted membrane protein [Function unknown]; Region: COG2259 393127008556 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 393127008557 Predicted membrane protein [Function unknown]; Region: COG4769 393127008558 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 393127008559 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 393127008560 substrate binding pocket [chemical binding]; other site 393127008561 chain length determination region; other site 393127008562 substrate-Mg2+ binding site; other site 393127008563 catalytic residues [active] 393127008564 aspartate-rich region 1; other site 393127008565 active site lid residues [active] 393127008566 aspartate-rich region 2; other site 393127008567 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 393127008568 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 393127008569 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 393127008570 active site 393127008571 metal binding site [ion binding]; metal-binding site 393127008572 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 393127008573 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 393127008574 hypothetical protein; Provisional; Region: PRK02947 393127008575 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127008576 putative active site [active] 393127008577 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 393127008578 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 393127008579 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 393127008580 active site 393127008581 substrate binding pocket [chemical binding]; other site 393127008582 homodimer interaction site [polypeptide binding]; other site 393127008583 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 393127008584 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 393127008585 active site 393127008586 P-loop; other site 393127008587 phosphorylation site [posttranslational modification] 393127008588 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127008589 active site 393127008590 phosphorylation site [posttranslational modification] 393127008591 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127008592 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127008593 PRD domain; Region: PRD; pfam00874 393127008594 PRD domain; Region: PRD; pfam00874 393127008595 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127008596 active site 393127008597 P-loop; other site 393127008598 phosphorylation site [posttranslational modification] 393127008599 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127008600 active site 393127008601 phosphorylation site [posttranslational modification] 393127008602 elongation factor Tu; Reviewed; Region: PRK00049 393127008603 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 393127008604 G1 box; other site 393127008605 GEF interaction site [polypeptide binding]; other site 393127008606 GTP/Mg2+ binding site [chemical binding]; other site 393127008607 Switch I region; other site 393127008608 G2 box; other site 393127008609 G3 box; other site 393127008610 Switch II region; other site 393127008611 G4 box; other site 393127008612 G5 box; other site 393127008613 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 393127008614 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 393127008615 Antibiotic Binding Site [chemical binding]; other site 393127008616 elongation factor G; Reviewed; Region: PRK00007 393127008617 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 393127008618 G1 box; other site 393127008619 putative GEF interaction site [polypeptide binding]; other site 393127008620 GTP/Mg2+ binding site [chemical binding]; other site 393127008621 Switch I region; other site 393127008622 G2 box; other site 393127008623 G3 box; other site 393127008624 Switch II region; other site 393127008625 G4 box; other site 393127008626 G5 box; other site 393127008627 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 393127008628 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 393127008629 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 393127008630 30S ribosomal protein S7; Validated; Region: PRK05302 393127008631 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 393127008632 S17 interaction site [polypeptide binding]; other site 393127008633 S8 interaction site; other site 393127008634 16S rRNA interaction site [nucleotide binding]; other site 393127008635 streptomycin interaction site [chemical binding]; other site 393127008636 23S rRNA interaction site [nucleotide binding]; other site 393127008637 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 393127008638 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 393127008639 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 393127008640 Zn2+ binding site [ion binding]; other site 393127008641 Mg2+ binding site [ion binding]; other site 393127008642 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 393127008643 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127008644 Coenzyme A binding pocket [chemical binding]; other site 393127008645 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127008646 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127008647 substrate binding site [chemical binding]; other site 393127008648 hexamer interface [polypeptide binding]; other site 393127008649 metal binding site [ion binding]; metal-binding site 393127008650 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 393127008651 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 393127008652 TPP-binding site [chemical binding]; other site 393127008653 dimer interface [polypeptide binding]; other site 393127008654 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 393127008655 PYR/PP interface [polypeptide binding]; other site 393127008656 dimer interface [polypeptide binding]; other site 393127008657 TPP binding site [chemical binding]; other site 393127008658 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 393127008659 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 393127008660 substrate binding site [chemical binding]; other site 393127008661 hexamer interface [polypeptide binding]; other site 393127008662 metal binding site [ion binding]; metal-binding site 393127008663 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 393127008664 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393127008665 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 393127008666 putative NAD(P) binding site [chemical binding]; other site 393127008667 catalytic Zn binding site [ion binding]; other site 393127008668 structural Zn binding site [ion binding]; other site 393127008669 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393127008670 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 393127008671 putative NAD(P) binding site [chemical binding]; other site 393127008672 catalytic Zn binding site [ion binding]; other site 393127008673 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 393127008674 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 393127008675 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 393127008676 active site 393127008677 P-loop; other site 393127008678 phosphorylation site [posttranslational modification] 393127008679 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127008680 active site 393127008681 phosphorylation site [posttranslational modification] 393127008682 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127008683 PRD domain; Region: PRD; pfam00874 393127008684 PRD domain; Region: PRD; pfam00874 393127008685 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127008686 active site 393127008687 P-loop; other site 393127008688 phosphorylation site [posttranslational modification] 393127008689 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127008690 active site 393127008691 phosphorylation site [posttranslational modification] 393127008692 Predicted membrane protein [Function unknown]; Region: COG4905 393127008693 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 393127008694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 393127008695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 393127008696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 393127008697 active site 393127008698 Helix-turn-helix domain; Region: HTH_18; pfam12833 393127008699 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 393127008700 Ligand Binding Site [chemical binding]; other site 393127008701 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 393127008702 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 393127008703 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 393127008704 active site 393127008705 DNA binding site [nucleotide binding] 393127008706 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 393127008707 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 393127008708 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 393127008709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 393127008710 active site 393127008711 phosphorylation site [posttranslational modification] 393127008712 intermolecular recognition site; other site 393127008713 dimerization interface [polypeptide binding]; other site 393127008714 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 393127008715 DNA binding site [nucleotide binding] 393127008716 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 393127008717 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 393127008718 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 393127008719 Ligand Binding Site [chemical binding]; other site 393127008720 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 393127008721 GAF domain; Region: GAF_3; pfam13492 393127008722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 393127008723 dimer interface [polypeptide binding]; other site 393127008724 phosphorylation site [posttranslational modification] 393127008725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 393127008726 ATP binding site [chemical binding]; other site 393127008727 Mg2+ binding site [ion binding]; other site 393127008728 G-X-G motif; other site 393127008729 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 393127008730 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 393127008731 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127008732 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 393127008733 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127008734 active site 393127008735 P-loop; other site 393127008736 phosphorylation site [posttranslational modification] 393127008737 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127008738 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127008739 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127008740 methionine cluster; other site 393127008741 active site 393127008742 phosphorylation site [posttranslational modification] 393127008743 metal binding site [ion binding]; metal-binding site 393127008744 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393127008745 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 393127008746 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 393127008747 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 393127008748 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 393127008749 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 393127008750 Soluble P-type ATPase [General function prediction only]; Region: COG4087 393127008751 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 393127008752 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127008753 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127008754 autolysin; Reviewed; Region: PRK06347 393127008755 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 393127008756 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008758 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 393127008760 Protein of unknown function (DUF970); Region: DUF970; pfam06153 393127008761 thymidylate kinase; Validated; Region: tmk; PRK00698 393127008762 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 393127008763 TMP-binding site; other site 393127008764 ATP-binding site [chemical binding]; other site 393127008765 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 393127008766 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 393127008767 homodimer interface [polypeptide binding]; other site 393127008768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127008769 catalytic residue [active] 393127008770 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 393127008771 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 393127008772 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393127008773 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 393127008774 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 393127008775 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 393127008776 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127008777 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127008778 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127008779 putative active site [active] 393127008780 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 393127008781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127008782 active site 393127008783 motif I; other site 393127008784 motif II; other site 393127008785 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393127008786 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 393127008787 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 393127008788 active site 393127008789 catalytic tetrad [active] 393127008790 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 393127008791 recombination protein RecR; Reviewed; Region: recR; PRK00076 393127008792 RecR protein; Region: RecR; pfam02132 393127008793 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 393127008794 putative active site [active] 393127008795 putative metal-binding site [ion binding]; other site 393127008796 tetramer interface [polypeptide binding]; other site 393127008797 hypothetical protein; Validated; Region: PRK00153 393127008798 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 393127008799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 393127008800 Walker A motif; other site 393127008801 ATP binding site [chemical binding]; other site 393127008802 Walker B motif; other site 393127008803 arginine finger; other site 393127008804 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 393127008805 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 393127008806 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 393127008807 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127008808 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127008809 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 393127008810 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 393127008811 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 393127008812 N- and C-terminal domain interface [polypeptide binding]; other site 393127008813 active site 393127008814 catalytic site [active] 393127008815 metal binding site [ion binding]; metal-binding site 393127008816 carbohydrate binding site [chemical binding]; other site 393127008817 ATP binding site [chemical binding]; other site 393127008818 SH3-like domain; Region: SH3_8; pfam13457 393127008819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 393127008820 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 393127008821 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127008822 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 393127008823 Walker A/P-loop; other site 393127008824 ATP binding site [chemical binding]; other site 393127008825 Q-loop/lid; other site 393127008826 ABC transporter signature motif; other site 393127008827 Walker B; other site 393127008828 D-loop; other site 393127008829 H-loop/switch region; other site 393127008830 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 393127008831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127008832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127008833 Walker A/P-loop; other site 393127008834 ATP binding site [chemical binding]; other site 393127008835 Q-loop/lid; other site 393127008836 ABC transporter signature motif; other site 393127008837 Walker B; other site 393127008838 D-loop; other site 393127008839 H-loop/switch region; other site 393127008840 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 393127008841 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 393127008842 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 393127008843 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 393127008844 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 393127008845 nucleoside/Zn binding site; other site 393127008846 dimer interface [polypeptide binding]; other site 393127008847 catalytic motif [active] 393127008848 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 393127008849 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 393127008850 active site 393127008851 acyl-activating enzyme (AAE) consensus motif; other site 393127008852 putative CoA binding site [chemical binding]; other site 393127008853 AMP binding site [chemical binding]; other site 393127008854 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 393127008855 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 393127008856 active site 393127008857 trimer interface [polypeptide binding]; other site 393127008858 allosteric site; other site 393127008859 active site lid [active] 393127008860 hexamer (dimer of trimers) interface [polypeptide binding]; other site 393127008861 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 393127008862 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 393127008863 DNA binding residues [nucleotide binding] 393127008864 drug binding residues [chemical binding]; other site 393127008865 dimer interface [polypeptide binding]; other site 393127008866 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 393127008867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127008868 Coenzyme A binding pocket [chemical binding]; other site 393127008869 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 393127008870 active site 393127008871 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 393127008872 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 393127008873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 393127008874 MarR family; Region: MarR; pfam01047 393127008875 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 393127008876 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 393127008877 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 393127008878 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 393127008879 DNA binding residues [nucleotide binding] 393127008880 putative dimer interface [polypeptide binding]; other site 393127008881 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 393127008882 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 393127008883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127008884 active site 393127008885 motif I; other site 393127008886 motif II; other site 393127008887 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127008888 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127008889 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127008890 putative active site [active] 393127008891 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 393127008892 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127008893 active site 393127008894 phosphorylation site [posttranslational modification] 393127008895 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 393127008896 active site 393127008897 P-loop; other site 393127008898 phosphorylation site [posttranslational modification] 393127008899 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 393127008900 alpha-mannosidase; Provisional; Region: PRK09819 393127008901 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 393127008902 active site 393127008903 metal binding site [ion binding]; metal-binding site 393127008904 catalytic site [active] 393127008905 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 393127008906 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 393127008907 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 393127008908 active site 393127008909 homodimer interface [polypeptide binding]; other site 393127008910 catalytic site [active] 393127008911 glycerate kinase; Region: TIGR00045 393127008912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127008913 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127008914 DNA binding site [nucleotide binding] 393127008915 domain linker motif; other site 393127008916 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 393127008917 putative dimerization interface [polypeptide binding]; other site 393127008918 putative ligand binding site [chemical binding]; other site 393127008919 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 393127008920 Domain of unknown function DUF21; Region: DUF21; pfam01595 393127008921 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 393127008922 Transporter associated domain; Region: CorC_HlyC; pfam03471 393127008923 NAD-dependent deacetylase; Provisional; Region: PRK00481 393127008924 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 393127008925 NAD+ binding site [chemical binding]; other site 393127008926 substrate binding site [chemical binding]; other site 393127008927 putative Zn binding site [ion binding]; other site 393127008928 Pathogenicity locus; Region: Cdd1; pfam11731 393127008929 drug efflux system protein MdtG; Provisional; Region: PRK09874 393127008930 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127008931 putative substrate translocation pore; other site 393127008932 Src Homology 3 domain superfamily; Region: SH3; cl17036 393127008933 Variant SH3 domain; Region: SH3_2; pfam07653 393127008934 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 393127008935 active site 393127008936 intersubunit interactions; other site 393127008937 catalytic residue [active] 393127008938 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 393127008939 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 393127008940 ligand binding site [chemical binding]; other site 393127008941 flexible hinge region; other site 393127008942 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 393127008943 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127008944 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127008945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127008946 Walker A/P-loop; other site 393127008947 ATP binding site [chemical binding]; other site 393127008948 Q-loop/lid; other site 393127008949 ABC transporter signature motif; other site 393127008950 Walker B; other site 393127008951 D-loop; other site 393127008952 H-loop/switch region; other site 393127008953 TfoX C-terminal domain; Region: TfoX_C; pfam04994 393127008954 seryl-tRNA synthetase; Provisional; Region: PRK05431 393127008955 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 393127008956 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 393127008957 dimer interface [polypeptide binding]; other site 393127008958 active site 393127008959 motif 1; other site 393127008960 motif 2; other site 393127008961 motif 3; other site 393127008962 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 393127008963 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 393127008964 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 393127008965 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 393127008966 glutamine binding [chemical binding]; other site 393127008967 catalytic triad [active] 393127008968 aminodeoxychorismate synthase; Provisional; Region: PRK07508 393127008969 chorismate binding enzyme; Region: Chorismate_bind; cl10555 393127008970 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 393127008971 substrate-cofactor binding pocket; other site 393127008972 homodimer interface [polypeptide binding]; other site 393127008973 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 393127008974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 393127008975 catalytic residue [active] 393127008976 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127008977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127008978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127008979 Walker A/P-loop; other site 393127008980 ATP binding site [chemical binding]; other site 393127008981 Q-loop/lid; other site 393127008982 ABC transporter signature motif; other site 393127008983 Walker B; other site 393127008984 D-loop; other site 393127008985 H-loop/switch region; other site 393127008986 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 393127008987 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 393127008988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 393127008989 Walker A/P-loop; other site 393127008990 ATP binding site [chemical binding]; other site 393127008991 Q-loop/lid; other site 393127008992 ABC transporter signature motif; other site 393127008993 Walker B; other site 393127008994 D-loop; other site 393127008995 H-loop/switch region; other site 393127008996 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 393127008997 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 393127008998 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 393127008999 Predicted acyl esterases [General function prediction only]; Region: COG2936 393127009000 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 393127009001 DNA topoisomerase III; Provisional; Region: PRK07726 393127009002 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 393127009003 active site 393127009004 putative interdomain interaction site [polypeptide binding]; other site 393127009005 putative metal-binding site [ion binding]; other site 393127009006 putative nucleotide binding site [chemical binding]; other site 393127009007 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 393127009008 domain I; other site 393127009009 DNA binding groove [nucleotide binding] 393127009010 phosphate binding site [ion binding]; other site 393127009011 domain II; other site 393127009012 domain III; other site 393127009013 nucleotide binding site [chemical binding]; other site 393127009014 catalytic site [active] 393127009015 domain IV; other site 393127009016 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 393127009017 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 393127009018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 393127009019 ATP binding site [chemical binding]; other site 393127009020 putative Mg++ binding site [ion binding]; other site 393127009021 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 393127009022 nucleotide binding region [chemical binding]; other site 393127009023 ATP-binding site [chemical binding]; other site 393127009024 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 393127009025 HRDC domain; Region: HRDC; pfam00570 393127009026 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 393127009027 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 393127009028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 393127009029 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 393127009030 active site 393127009031 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 393127009032 putative ADP-ribose binding site [chemical binding]; other site 393127009033 putative active site [active] 393127009034 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 393127009035 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127009036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127009037 ABC transporter; Region: ABC_tran_2; pfam12848 393127009038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 393127009039 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 393127009040 beta-galactosidase; Region: BGL; TIGR03356 393127009041 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127009042 active site 393127009043 P-loop; other site 393127009044 phosphorylation site [posttranslational modification] 393127009045 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 393127009046 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127009047 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127009048 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127009049 nucleotide binding site [chemical binding]; other site 393127009050 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127009051 methionine cluster; other site 393127009052 active site 393127009053 phosphorylation site [posttranslational modification] 393127009054 metal binding site [ion binding]; metal-binding site 393127009055 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127009056 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127009057 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127009058 putative active site [active] 393127009059 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 393127009060 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 393127009061 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 393127009062 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 393127009063 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 393127009064 Walker A/P-loop; other site 393127009065 ATP binding site [chemical binding]; other site 393127009066 Q-loop/lid; other site 393127009067 ABC transporter signature motif; other site 393127009068 Walker B; other site 393127009069 D-loop; other site 393127009070 H-loop/switch region; other site 393127009071 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 393127009072 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 393127009073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 393127009074 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 393127009075 beta-galactosidase; Region: BGL; TIGR03356 393127009076 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393127009077 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127009078 active site turn [active] 393127009079 phosphorylation site [posttranslational modification] 393127009080 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127009081 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 393127009082 HPr interaction site; other site 393127009083 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127009084 active site 393127009085 phosphorylation site [posttranslational modification] 393127009086 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393127009087 CAT RNA binding domain; Region: CAT_RBD; smart01061 393127009088 PRD domain; Region: PRD; pfam00874 393127009089 PRD domain; Region: PRD; pfam00874 393127009090 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 393127009091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009092 putative substrate translocation pore; other site 393127009093 GTP-binding protein YchF; Reviewed; Region: PRK09601 393127009094 YchF GTPase; Region: YchF; cd01900 393127009095 G1 box; other site 393127009096 GTP/Mg2+ binding site [chemical binding]; other site 393127009097 Switch I region; other site 393127009098 G2 box; other site 393127009099 Switch II region; other site 393127009100 G3 box; other site 393127009101 G4 box; other site 393127009102 G5 box; other site 393127009103 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 393127009104 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 393127009105 methionine cluster; other site 393127009106 active site 393127009107 phosphorylation site [posttranslational modification] 393127009108 metal binding site [ion binding]; metal-binding site 393127009109 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 393127009110 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 393127009111 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 393127009112 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 393127009113 active site 393127009114 P-loop; other site 393127009115 phosphorylation site [posttranslational modification] 393127009116 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 393127009117 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 393127009118 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 393127009119 HTH domain; Region: HTH_11; pfam08279 393127009120 Mga helix-turn-helix domain; Region: Mga; pfam05043 393127009121 PRD domain; Region: PRD; pfam00874 393127009122 PRD domain; Region: PRD; pfam00874 393127009123 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 393127009124 active site 393127009125 P-loop; other site 393127009126 phosphorylation site [posttranslational modification] 393127009127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127009128 active site 393127009129 phosphorylation site [posttranslational modification] 393127009130 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 393127009131 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 393127009132 tetramer interface [polypeptide binding]; other site 393127009133 heme binding pocket [chemical binding]; other site 393127009134 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 393127009135 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 393127009136 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 393127009137 active site turn [active] 393127009138 phosphorylation site [posttranslational modification] 393127009139 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 393127009140 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 393127009141 HPr interaction site; other site 393127009142 glycerol kinase (GK) interaction site [polypeptide binding]; other site 393127009143 active site 393127009144 phosphorylation site [posttranslational modification] 393127009145 transcriptional antiterminator BglG; Provisional; Region: PRK09772 393127009146 CAT RNA binding domain; Region: CAT_RBD; pfam03123 393127009147 PRD domain; Region: PRD; pfam00874 393127009148 PRD domain; Region: PRD; pfam00874 393127009149 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 393127009150 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 393127009151 ParB-like nuclease domain; Region: ParB; smart00470 393127009152 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 393127009153 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 393127009154 P-loop; other site 393127009155 Magnesium ion binding site [ion binding]; other site 393127009156 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 393127009157 Magnesium ion binding site [ion binding]; other site 393127009158 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 393127009159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 393127009160 non-specific DNA binding site [nucleotide binding]; other site 393127009161 salt bridge; other site 393127009162 sequence-specific DNA binding site [nucleotide binding]; other site 393127009163 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 393127009164 ParB-like nuclease domain; Region: ParBc; pfam02195 393127009165 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 393127009166 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 393127009167 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 393127009168 putative active site [active] 393127009169 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 393127009170 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 393127009171 nucleotide binding site [chemical binding]; other site 393127009172 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 393127009173 active site 393127009174 phosphorylation site [posttranslational modification] 393127009175 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 393127009176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127009177 motif II; other site 393127009178 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 393127009179 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 393127009180 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 393127009181 active site 393127009182 P-loop; other site 393127009183 phosphorylation site [posttranslational modification] 393127009184 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127009185 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127009186 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393127009187 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 393127009188 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 393127009189 putative active site cavity [active] 393127009190 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 393127009191 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 393127009192 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 393127009193 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 393127009194 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 393127009195 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 393127009196 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 393127009197 trmE is a tRNA modification GTPase; Region: trmE; cd04164 393127009198 G1 box; other site 393127009199 GTP/Mg2+ binding site [chemical binding]; other site 393127009200 Switch I region; other site 393127009201 G2 box; other site 393127009202 Switch II region; other site 393127009203 G3 box; other site 393127009204 G4 box; other site 393127009205 G5 box; other site 393127009206 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 393127009207 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 393127009208 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 393127009209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 393127009210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 393127009211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 393127009212 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 393127009213 NADP binding site [chemical binding]; other site 393127009214 homodimer interface [polypeptide binding]; other site 393127009215 active site 393127009216 substrate binding site [chemical binding]; other site 393127009217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009218 D-galactonate transporter; Region: 2A0114; TIGR00893 393127009219 putative substrate translocation pore; other site 393127009220 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393127009221 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 393127009222 metal binding site [ion binding]; metal-binding site 393127009223 dimer interface [polypeptide binding]; other site 393127009224 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 393127009225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 393127009226 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 393127009227 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 393127009228 metal binding site [ion binding]; metal-binding site 393127009229 dimer interface [polypeptide binding]; other site 393127009230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127009231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 393127009232 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 393127009233 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 393127009234 Leucine-rich repeats; other site 393127009235 Substrate binding site [chemical binding]; other site 393127009236 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 393127009237 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127009238 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127009239 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127009240 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 393127009241 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 393127009242 Uncharacterized conserved protein [Function unknown]; Region: COG4198 393127009243 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 393127009244 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 393127009245 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 393127009246 putative ligand binding site [chemical binding]; other site 393127009247 putative NAD binding site [chemical binding]; other site 393127009248 putative catalytic site [active] 393127009249 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 393127009250 L-serine binding site [chemical binding]; other site 393127009251 ACT domain interface; other site 393127009252 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 393127009253 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 393127009254 catalytic residue [active] 393127009255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127009257 putative substrate translocation pore; other site 393127009258 Transcriptional regulators [Transcription]; Region: MarR; COG1846 393127009259 MarR family; Region: MarR_2; pfam12802 393127009260 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 393127009261 dimer interface [polypeptide binding]; other site 393127009262 FMN binding site [chemical binding]; other site 393127009263 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 393127009264 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 393127009265 catalytic residues [active] 393127009266 beta-phosphoglucomutase; Region: bPGM; TIGR01990 393127009267 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 393127009268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 393127009269 motif II; other site 393127009270 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 393127009271 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 393127009272 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 393127009273 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 393127009274 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 393127009275 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 393127009276 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 393127009277 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 393127009278 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 393127009279 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 393127009280 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 393127009281 putative NAD(P) binding site [chemical binding]; other site 393127009282 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 393127009283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127009284 dimer interface [polypeptide binding]; other site 393127009285 conserved gate region; other site 393127009286 putative PBP binding loops; other site 393127009287 ABC-ATPase subunit interface; other site 393127009288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 393127009289 dimer interface [polypeptide binding]; other site 393127009290 conserved gate region; other site 393127009291 putative PBP binding loops; other site 393127009292 ABC-ATPase subunit interface; other site 393127009293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 393127009294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 393127009295 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 393127009296 sucrose phosphorylase; Provisional; Region: PRK13840 393127009297 active site 393127009298 homodimer interface [polypeptide binding]; other site 393127009299 catalytic site [active] 393127009300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 393127009301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 393127009302 DNA binding site [nucleotide binding] 393127009303 domain linker motif; other site 393127009304 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 393127009305 putative dimerization interface [polypeptide binding]; other site 393127009306 putative ligand binding site [chemical binding]; other site 393127009307 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 393127009308 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 393127009309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 393127009310 Coenzyme A binding pocket [chemical binding]; other site 393127009311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127009313 putative substrate translocation pore; other site 393127009314 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009315 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 393127009316 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 393127009317 intersubunit interface [polypeptide binding]; other site 393127009318 active site 393127009319 Zn2+ binding site [ion binding]; other site 393127009320 L-rhamnose isomerase; Provisional; Region: PRK01076 393127009321 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 393127009322 N- and C-terminal domain interface [polypeptide binding]; other site 393127009323 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 393127009324 active site 393127009325 putative catalytic site [active] 393127009326 metal binding site [ion binding]; metal-binding site 393127009327 ATP binding site [chemical binding]; other site 393127009328 carbohydrate binding site [chemical binding]; other site 393127009329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 393127009330 putative substrate translocation pore; other site 393127009331 Major Facilitator Superfamily; Region: MFS_1; pfam07690 393127009332 Cupin domain; Region: Cupin_2; pfam07883 393127009333 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 393127009334 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 393127009335 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 393127009336 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 393127009337 G-X-X-G motif; other site 393127009338 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 393127009339 RxxxH motif; other site 393127009340 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 393127009341 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 393127009342 ribonuclease P; Reviewed; Region: rnpA; PRK00499 393127009343 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399