-- dump date 20140619_132632 -- class Genbank::CDS -- table cds_note -- id note YP_002348984.1 protein of unknown function YP_002348985.1 formate dehydrogenase Alpha subunit YP_002348986.1 conserved hypothetical protein YP_002348987.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002348988.1 alkaline phosphatase synthesis transcriptional regulatory proteinphoP YP_002348991.1 macrolide export ATP-binding/permease MacB YP_002348992.1 listeria-Bacteroides repeat domain (List_Bact_rpt) family YP_002348994.1 cell wall surface anchor family protein YP_002348997.1 conserved hypothetical protein YP_002348999.1 conserved hypothetical protein YP_002349000.1 alcohol dehydrogenase, zinc-dependent YP_002349001.1 riboflavin biosynthesis protein RibD C- domain protein YP_002349003.1 membrane protein YP_002349005.1 bacterial extracellular solute-binding protein, family 5 YP_002349006.1 conserved hypothetical protein YP_002349007.1 conserved hypothetical protein YP_002349008.1 biotin/lipoate A/B protein ligase family protein YP_002349009.1 HD domain protein YP_002349010.1 conserved domain protein YP_002349012.1 conserved hypothetical protein YP_002349013.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002349014.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_002349015.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002349018.1 similar to YegS from E. coli YP_002349019.1 fructose-1,6-bisphosphate aldolase, class II YP_002349020.1 glycosyl transferase, group 1 family protein YP_002349022.1 integral membrane protein YP_002349023.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002349024.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002349026.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002349027.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_002349028.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002349029.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002349030.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002349031.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002349032.1 protein-(glutamine-N5) methyltransferase, release factor-specific YP_002349034.1 low molecular weight phosphotyrosine protein phosphatase family protein YP_002349035.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002349036.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002349039.1 AtpI YP_002349040.1 ATP synthase, A subunit YP_002349041.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002349042.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002349043.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002349044.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002349045.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002349046.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002349047.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002349048.1 conserved hypothetical integral membrane protein YP_002349049.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002349050.1 Rod shape-determining protein MreB YP_002349051.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002349052.1 single-strand binding protein family YP_002349053.1 LysM domain protein YP_002349055.1 N-acetylmannosaminyltransferase (UDP-N-acetylmannosamine transferase) (N-acetylglucosaminyldiphospho-undecaprenol N-acetyl-beta-D-mannosaminyltransferase) (Major teichoicacid biosynthesis protein A) YP_002349056.1 O-succinylbenzoic acid (OSB) synthetase YP_002349057.1 undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphatetransferase (UDP-GlcNAc:undecaprenyl-P GlcNAc 1-Ptransferase) YP_002349059.1 acetyltransferase, gnat family YP_002349060.1 conserved hypothetical protein YP_002349061.1 transcriptional regulatory protein DegU (Protease production enhancerprotein) YP_002349063.1 ComF operon protein 1 (ATP-dependent helicase comFA) YP_002349066.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002349067.1 peptide chain release factor 2, programmed YP_002349070.1 Cell division protein FtsX homolog YP_002349074.1 membrane protein YP_002349077.1 phosphate ABC transporter phosphate-binding protein YP_002349078.1 phosphate ABC transporter permease PstC YP_002349079.1 phosphate ABC transporter permease PstA YP_002349080.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002349081.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002349084.1 conserved hypothetical protein YP_002349085.1 HD domain protein YP_002349086.1 conserved hypothetical protein YP_002349087.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002349088.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002349089.1 conserved hypothetical protein YP_002349090.1 PspC domain protein YP_002349091.1 conserved domain protein YP_002349093.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_002349094.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002349095.1 hydrolyzes pyrophosphate formed during serine-46-phosphorylated HPr dephosphorylation YP_002349096.1 transferase hexapeptide repeat containing protein YP_002349097.1 TPR domain protein YP_002349102.1 conserved hypothetical protein YP_002349103.1 conserved hypothetical protein YP_002349104.1 conserved hypothetical protein YP_002349105.1 catalyzes the reduction of alpha, beta-unsaturated aldehydes and ketones; reduces the nitro group nitroester and nitroaromatic compounds YP_002349107.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002349110.1 conserved hypothetical protein YP_002349111.1 conserved hypothetical protein YP_002349114.1 renal dipeptidase family protein YP_002349115.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002349118.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002349119.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002349120.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002349121.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002349122.1 conserved hypothetical protein YP_002349123.1 conserved hypothetical protein YP_002349125.1 preprotein translocase, SecG subunit YP_002349128.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002349129.1 transcriptional activator, Rgg/GadR/MutR family, C- domain YP_002349130.1 glycosyl hydrolase, family 31 YP_002349134.1 conserved hypothetical protein YP_002349136.1 conserved hypothetical protein YP_002349139.1 conserved hypothetical protein YP_002349140.1 conserved hypothetical protein YP_002349143.1 conserved hypothetical protein YP_002349146.1 conserved hypothetical protein YP_002349153.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002349158.1 conserved hypothetical protein YP_002349165.1 Selenocysteine lyase; Selenocysteine reductase; Selenocysteine beta-lyase; SCL YP_002349168.1 conserved protein YunF YP_002349170.1 transport protein YP_002349172.1 YutD YP_002349173.1 HAD-superfamily subfamily IIA hydrolase YP_002349174.1 acetyltransferase, gnat family YP_002349175.1 CBS domain protein YP_002349177.1 conserved domain protein YP_002349179.1 conserved protein YuzD YP_002349180.1 conserved domain protein YP_002349184.1 conserved hypothetical protein YP_002349185.1 conserved hypothetical protein YP_002349186.1 membrane protein YP_002349187.1 YuiD YP_002349189.1 subunit G of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002349190.1 subunit F of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002349191.1 subunit E of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002349192.1 subunit D of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; contains an oxidoreductase domain; catalyzes the transfer of electrons from NADH to ubiquinone YP_002349193.1 subunit C of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002349194.1 subunit B of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali; in the case of S. meliloti it was proved to be involved specifically with K+ transport YP_002349195.1 subunit A of antiporter complex involved in resistance to high concentrations of Na+, K+, Li+ and/or alkali YP_002349198.1 conserved hypothetical protein YP_002349199.1 conserved hypothetical protein YP_002349200.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_002349201.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002349205.1 induced by heat shock, salt stress, oxidative stress, glucose limitation and oxygen limitation YP_002349207.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002349209.1 conserved hypothetical protein YP_002349210.1 secreted protein YP_002349220.1 conserved hypothetical protein YP_002349222.1 conserved hypothetical protein YP_002349223.1 conserved hypothetical protein YP_002349226.1 conserved hypothetical protein YP_002349230.1 acetyltransferase, gnat family YP_002349235.1 bacterial luciferase family protein YP_002349237.1 nitrilotriacetate monooxygenase component A (NTAmonooxygenase component A) (NTA-MO A) YP_002349241.1 YbbK YP_002349242.1 aminopeptidase C (Bleomycin hydrolase) YP_002349252.1 conserved hypothetical protein YP_002349253.1 YitT YP_002349254.1 HAD-superfamily hydrolase, subfamily IIB YP_002349255.1 conserved hypothetical protein YP_002349256.1 conserved hypothetical protein YP_002349257.1 acetyltransferase, gnat family YP_002349258.1 PTS system, beta-glucoside-specific, IIA component YP_002349259.1 conserved domain protein YP_002349260.1 intracellular protease 1 (Intracellular protease I) YP_002349261.1 conserved hypothetical protein YP_002349264.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002349266.1 amino acid ABC transporter permease, His/Glu/Gln/Arg/opine family YP_002349267.1 phosphate transporter family protein YP_002349269.1 2,5-diketo-d-gluconic acid reductase a (2,5-dkgreductase a) (2,5-dkgr a) (25dkgr-a) (akr5c) YP_002349272.1 ribosomal large subunit pseudouridine synthase, RluD subfamily YP_002349274.1 methylated-DNA--protein-cysteine methyltransferase (O-6-methylguanine-DNA alkyltransferase) YP_002349277.1 membrane protein YP_002349279.1 transport protein YP_002349280.1 catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002349281.1 NADH:flavin oxidoreductase, old yellow enzyme family YP_002349284.1 CBS domain protein YP_002349288.1 conserved hypothetical protein YP_002349290.1 membrane protein YP_002349291.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002349292.1 conserved hypothetical protein YP_002349293.1 conserved hypothetical protein YP_002349295.1 conserved hypothetical protein YP_002349296.1 catalyzes the exonucleic cleavage of mRNA yielding nucleioside 5'-phosphates YP_002349298.1 conserved hypothetical protein YP_002349299.1 conserved hypothetical protein YP_002349303.1 conserved hypothetical protein YP_002349304.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002349305.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002349306.1 conserved hypothetical protein YP_002349307.1 acetyltransferase, gnat family YP_002349308.1 conserved hypothetical protein YP_002349309.1 membrane protein YP_002349311.1 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (phosphoglyceromutase) (pgam) (bpg-dependent pgam) (dpgm) YP_002349312.1 conserved hypothetical protein YP_002349313.1 N-acetylmuramoyl-L-alanine amidase, family 4 YP_002349314.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002349315.1 3-oxoacyl-ACP synthase 2 YP_002349318.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002349319.1 conserved hypothetical protein YP_002349320.1 oligopeptide ABC transporter oligopeptide-binding protein YP_002349325.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_002349326.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_002349327.1 conserved hypothetical protein YP_002349329.1 conserved hypothetical protein YP_002349333.1 iron compound ABC transporter iron compound-binding protein YP_002349336.1 sortase, SrtB family YP_002349337.1 conserved hypothetical protein YP_002349341.1 conserved hypothetical protein YP_002349343.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002349349.1 conserved hypothetical protein YP_002349360.1 conserved domain protein YP_002349361.1 conserved hypothetical protein YP_002349362.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002349363.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002349364.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002349366.1 conserved hypothetical protein YP_002349369.1 membrane protein YP_002349370.1 similar to membrane protein Lmo2147 YP_002349374.1 mannose-6-phosphate isomerase, class I YP_002349375.1 conserved hypothetical protein YP_002349376.1 acetyltransferase, gnat family YP_002349380.1 PTS system, fructose-specific IIA component YP_002349381.1 PTS system, fructose-specific IIB component YP_002349384.1 fructose-bisphosphate aldolase, class II family YP_002349385.1 conserved hypothetical protein YP_002349386.1 cyclic nucleotide-binding domain protein YP_002349388.1 conserved hypothetical protein YP_002349395.1 conserved hypothetical protein YP_002349397.1 conserved hypothetical protein YP_002349398.1 conserved hypothetical protein YP_002349399.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002349400.1 acetyltransferase, gnat family YP_002349401.1 membrane protein YP_002349404.1 conserved hypothetical protein YP_002349407.1 mannose-6-phosphate isomerase, class I YP_002349408.1 hydrolase, alpha/beta fold family YP_002349412.1 conserved hypothetical protein YP_002349414.1 conserved domain protein YP_002349415.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002349417.1 conserved hypothetical protein YP_002349418.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_002349419.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_002349420.1 GntR family transcriptional regulator/aminotransferase family protein YP_002349426.1 class II aldolase/adducin domain protein YP_002349427.1 conserved hypothetical protein YP_002349429.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002349430.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_002349440.1 conserved hypothetical protein YP_002349441.1 resolvase, N terminal domain YP_002349445.1 conserved hypothetical protein YP_002349446.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002349447.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002349450.1 conserved hypothetical protein YP_002349453.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002349457.1 modulates transcription in response to the NADH/NAD(+) redox state YP_002349458.1 conserved hypothetical protein YP_002349460.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002349461.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002349462.1 choloylglycine hydrolase (conjugated bile acidhydrolase) (cbah) (bile salt hydrolase) YP_002349463.1 conserved hypothetical protein YP_002349464.1 conserved hypothetical protein YP_002349467.1 homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002349468.1 conserved hypothetical protein YP_002349470.1 conserved hypothetical protein YP_002349474.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002349475.1 conserved hypothetical protein YP_002349477.1 conserved hypothetical protein YP_002349478.1 RNA methyltransferase, RsmD family YP_002349479.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002349480.1 conserved hypothetical protein YP_002349482.1 conserved hypothetical protein YP_002349483.1 conserved hypothetical protein YP_002349485.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002349486.1 conserved hypothetical protein YP_002349487.1 bacterial extracellular solute-binding protein, family 5 YP_002349488.1 permease of the major facilitator superfamily YP_002349489.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002349493.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase (UDP-N-acetylmuramyl-tripeptide synthetase) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase) YP_002349494.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase (UDP-N-acetylmuramyl-tripeptide synthetase) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-tripeptide synthetase) YP_002349495.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002349497.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002349498.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002349499.1 division initiation protein (Cell division and sporulation protein) YP_002349501.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002349503.1 YlmF YP_002349505.1 S4 domain protein YP_002349506.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002349507.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_002349508.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002349509.1 aminotransferase, class V YP_002349510.1 3H domain protein YP_002349512.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002349513.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002349515.1 conserved domain protein YP_002349517.1 glycosyl hydrolase, family 38 YP_002349518.1 conserved hypothetical protein YP_002349519.1 protein of unknown function YP_002349525.1 catalyzes the formation of 2-acetolactate from pyruvate in stationary phase YP_002349529.1 PTS system, mannose/fructose/sorbose family, IIB component YP_002349530.1 PTS system, IIC component YP_002349531.1 fructose permease iid component (PTS system fructose-specific eiidcomponent) (eiid-fru) (p30) YP_002349532.1 SIS domain protein YP_002349533.1 sugar isomerase domain protein YP_002349536.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002349538.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_002349540.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_002349541.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002349542.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002349543.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002349544.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_002349545.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002349546.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002349547.1 acetolactate synthase, large subunit, biosynthetic type YP_002349548.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002349550.1 acetyltransferase, gnat family YP_002349551.1 conserved hypothetical protein YP_002349552.1 conserved hypothetical protein YP_002349553.1 conserved hypothetical protein YP_002349554.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002349556.1 short-chain dehydrogenase/reductase YqjQ YP_002349557.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002349559.1 conserved hypothetical protein YP_002349560.1 adp-ribose pyrophosphatase (adp-ribose diphosphatase)(adenosine diphosphoribose pyrophosphatase) (adpr-ppase) (adp-ribosephosphohydrolase) (asppase) YP_002349561.1 conserved hypothetical protein YP_002349567.1 iron compound ABC transporter iron compound-binding protein YP_002349572.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002349573.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_002349575.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB YP_002349580.1 thioesterase domain protein YP_002349583.1 conserved hypothetical protein YP_002349585.1 LysM domain protein YP_002349586.1 L-asparaginase (L-asparagine amidohydrolase) (L-ASNase) YP_002349587.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002349588.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002349589.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002349590.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002349591.1 conserved hypothetical protein YP_002349592.1 DNA-binding protein HU 1 (DNA-binding protein II) (HB) YP_002349593.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002349595.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002349597.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002349598.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002349599.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002349601.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002349602.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_002349603.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002349604.1 TPR domain protein YP_002349605.1 conserved hypothetical protein YP_002349606.1 conserved hypothetical protein YP_002349608.1 conserved hypothetical protein YP_002349611.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002349612.1 EAL domain protein YP_002349613.1 conserved hypothetical protein YP_002349616.1 D-amino acid dehydrogenase, small subunit YP_002349617.1 conserved hypothetical protein YP_002349619.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002349620.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_002349621.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_002349622.1 biotin-(acetyl-CoA-carboxylase) ligase YP_002349624.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002349625.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002349626.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002349627.1 unwinds DNA YP_002349628.1 peptidase propeptide and ypeb domain protein YP_002349629.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_002349630.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002349633.1 conserved hypothetical protein YP_002349635.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_002349636.1 conserved hypothetical protein YP_002349637.1 conserved hypothetical protein YP_002349638.1 conserved hypothetical protein YP_002349641.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_002349644.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002349645.1 5-3 exonuclease family protein YP_002349647.1 conserved domain protein YP_002349648.1 involved in manganese homeostasis; activates the transcription of the mntABCD operon YP_002349649.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_002349651.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002349653.1 conserved hypothetical protein YP_002349658.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002349659.1 conserved hypothetical protein YP_002349660.1 CBS domain protein YP_002349663.1 conserved hypothetical protein YP_002349664.1 conserved hypothetical protein YP_002349665.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002349666.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002349668.1 conserved domain protein YP_002349669.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002349670.1 D-alanyl-D-alanine carboxypeptidase family protein YP_002349671.1 conserved hypothetical protein YP_002349673.1 conserved domain protein YP_002349680.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_002349682.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002349685.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_002349686.1 uracil permease (Uracil transporter) YP_002349687.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002349688.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002349689.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002349690.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002349692.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_002349693.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002349694.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002349697.1 conserved hypothetical protein YP_002349698.1 Essential for recycling GMP and indirectly, cGMP YP_002349699.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002349701.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002349706.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002349707.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002349709.1 required for 70S ribosome assembly YP_002349710.1 conserved hypothetical protein YP_002349711.1 DAK2 domain protein YP_002349712.1 L-serine dehydratase, iron-sulfur-dependent, beta subunit YP_002349713.1 L-serine dehydratase, iron-sulfur-dependent, alpha subunit YP_002349714.1 catalyzes branch migration in Holliday junction intermediates YP_002349715.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_002349716.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002349719.1 carries the fatty acid chain in fatty acid biosynthesis YP_002349720.1 conserved hypothetical protein YP_002349721.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002349724.1 helix-turn-helix protein, YlxM / p13 like YP_002349728.1 conserved hypothetical protein YP_002349729.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002349730.1 conserved domain protein YP_002349732.1 conserved hypothetical protein YP_002349733.1 Essential for efficient processing of 16S rRNA YP_002349734.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002349735.1 conserved hypothetical protein YP_002349739.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002349745.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002349746.1 ribosomal protein L35 YP_002349747.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002349749.1 conserved hypothetical protein YP_002349750.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002349751.1 conserved hypothetical protein YP_002349753.1 HD domain protein YP_002349754.1 conserved hypothetical protein YP_002349755.1 phosphoribosylaminoimidazole carboxylase, catalytic subunit YP_002349756.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002349757.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002349758.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002349759.1 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway YP_002349760.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002349761.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002349762.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002349763.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002349765.1 involved in de novo purine biosynthesis YP_002349766.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002349767.1 TrpR homolog YerC/YecD YP_002349768.1 conserved hypothetical protein YP_002349770.1 PcrB-like protein; GGGP synthase; member of prenyltransferases that transfer isoprenoid groups to nonisoprenoid acceptors; functions in form GGGP from glycerol-1-phosphate (G-1-P) and geranylgeranyl pyrophosphate (GGPP); important in lipid metabolism and especially important as the ether linkages in archaea are different than those in bacteria; GGGP synthase lies at the branch point for membrane lipid biosynthesis; cytosolic; T acidophilum protein acts as a homodimer while M thermoautotrophicum protein has been reported to function as a pentamer YP_002349772.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002349774.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_002349775.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002349776.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_002349777.1 similar to YegS from E. coli YP_002349778.1 conserved hypothetical protein YP_002349781.1 conserved hypothetical protein YP_002349783.1 conserved hypothetical protein YP_002349788.1 conserved hypothetical protein YP_002349795.1 acetyltransferase, gnat family YP_002349798.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002349803.1 conserved hypothetical protein YP_002349806.1 helicase domain protein YP_002349808.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002349809.1 lichenan-specific phosphotransferase enzyme iia component (PTS system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002349813.1 methyltransferase domain family YP_002349814.1 conserved hypothetical protein YP_002349815.1 cell shape determining protein, MreB/Mrl family YP_002349819.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002349821.1 conserved domain protein YP_002349823.1 deoxyguanosIne kinase (dguo kinase) (dgk)(deoxynucleoside kinase complex i f-component) YP_002349824.1 conserved hypothetical protein YP_002349826.1 conserved hypothetical protein YP_002349828.1 conserved hypothetical protein YP_002349829.1 conserved hypothetical protein YP_002349831.1 acetyltransferase, gnat family YP_002349835.1 conserved hypothetical protein YP_002349836.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002349837.1 conserved hypothetical protein YP_002349838.1 deoxyuridine 5-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase) YP_002349839.1 YfhP YP_002349841.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002349842.1 conserved hypothetical protein YP_002349844.1 converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate YP_002349848.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002349850.1 catalyzes the formation of L-homocysteine from cystathionine YP_002349851.1 catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine; expressed in B. subtilis under methionine starvation conditions YP_002349852.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002349854.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002349856.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002349857.1 converts O-succinylbenzoate to O-succinylbenzoyl-CoA YP_002349859.1 conserved hypothetical protein YP_002349861.1 conserved hypothetical protein YP_002349863.1 conserved hypothetical protein YP_002349864.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002349865.1 asparagine synthase (glutamine-hydrolyzing) YP_002349868.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002349870.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002349871.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002349872.1 conserved hypothetical protein YP_002349873.1 conserved hypothetical protein YP_002349879.1 1-acyl-sn-glycerol-3-phosphate acyltransferase domain protein YP_002349883.1 conserved hypothetical protein YP_002349885.1 Catalyzes the conversion of citrate to isocitrate YP_002349886.1 dna-3-methyladenine glycosylase 1 (dna-3-methyladenineglycosylase i) (3-methyladenine-dna glycosylase i, constitutive) (tagi) (dna-3-methyladenine glycosidase i) YP_002349888.1 ABC-type sugar transport system, ATPase component YP_002349891.1 aldehyde-alcohol dehydrogenase 2 YP_002349892.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002349893.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_002349894.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002349895.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_002349896.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_002349897.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002349898.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002349899.1 conserved hypothetical protein YP_002349903.1 YjeF homolog, C-terminus YP_002349905.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_002349910.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002349912.1 conserved hypothetical protein YP_002349915.1 conserved hypothetical protein YP_002349917.1 conserved hypothetical protein YP_002349918.1 tRNA-binding domain protein YP_002349920.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002349921.1 2-Cys peroxiredoxin BAS1, (Thiol-specific antioxidant protein) YP_002349923.1 conserved hypothetical protein YP_002349924.1 conserved hypothetical protein YP_002349925.1 catalyzes the formation of 3-deoxy-D-aribino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate and the formation of prephenate from chorismate YP_002349928.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002349929.1 GAF domain protein YP_002349930.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_002349931.1 cysteine desulfurase (Nitrogenase metalloclustersbiosynthesis protein NifS) YP_002349932.1 Required for the synthesis of the thiazole moiety YP_002349933.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002349934.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_002349935.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002349936.1 acetylornithine aminotransferase (ACOAT) YP_002349937.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_002349938.1 catalyzes the phosphorylation of NAD to NADP YP_002349940.1 conserved hypothetical protein YP_002349941.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_002349942.1 conserved hypothetical protein YP_002349949.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002349952.1 Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) YP_002349953.1 catalyzes the opening and hydrolysis of the beta-lactam ring of beta-lactam antibiotics such as penicillins and cephalosporins YP_002349954.1 CBS domain protein YP_002349957.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002349958.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002349960.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002349961.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002349962.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002349963.1 conserved membrane protein YtwI YP_002349964.1 catalyzes the formation of citrate from acetyl-CoA and oxaloacetate YP_002349965.1 Converts isocitrate to alpha ketoglutarate YP_002349966.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002349967.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002349968.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002349971.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_002349972.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_002349973.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002349974.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002349975.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002349976.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_002349977.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002349978.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002349979.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002349980.1 folylpolyglutamate synthase (folylpoly-gamma-glutamatesynthetase) (fpgs) (tetrahydrofolate synthase)(tetrahydrofolylpolyglutamate synthase) YP_002349982.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002349983.1 functions in MreBCD complex in some organisms YP_002349984.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002349986.1 blocks the formation of polar Z-ring septums YP_002349989.1 ribosomal protein L21 YP_002349990.1 conserved hypothetical protein YP_002349991.1 involved in the peptidyltransferase reaction during translation YP_002349993.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002349994.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002349995.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002349996.1 conserved hypothetical protein YP_002349998.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002349999.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002350000.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002350001.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002350002.1 preprotein translocase, YajC subunit YP_002350003.1 conserved hypothetical protein YP_002350004.1 part of the preprotein secretory system; forms a complex with protein YajC; SecDFyajC stimulates the proton motive force-driven protein translocation, seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002350005.1 conserved hypothetical protein YP_002350007.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002350008.1 GTP pyrophosphokinase (ATP:GTP 3-pyrophosphotransferase)(ppGpp synthetase I) ((P)ppGpp synthetase) YP_002350009.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002350010.1 N-acetylmuramoyl-L-alanine amidase, family 3 YP_002350011.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002350012.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002350013.1 conserved hypothetical protein YP_002350017.1 ATPase, AAA family domain protein YP_002350019.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002350020.1 conserved hypothetical protein YP_002350021.1 TPR domain protein YP_002350022.1 helicase, RecD/TraA family YP_002350027.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002350028.1 conserved hypothetical protein YP_002350029.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002350030.1 conserved hypothetical protein YP_002350034.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002350036.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002350037.1 conserved hypothetical protein YP_002350040.1 had superfamily (subfamily iiia) phosphatase YP_002350041.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_002350043.1 conserved hypothetical protein YP_002350044.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002350045.1 conserved hypothetical protein YP_002350046.1 iojap-related protein YP_002350051.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002350052.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002350053.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002350056.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002350057.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_002350058.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002350059.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002350060.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002350061.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002350062.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002350063.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002350064.1 GatB/Yqey domain protein YP_002350066.1 hdig domain protein YP_002350067.1 conserved hypothetical protein YP_002350068.1 diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) YP_002350070.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002350071.1 conserved hypothetical protein YP_002350072.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002350073.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002350074.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002350075.1 conserved hypothetical protein YP_002350076.1 protein (P17) YP_002350078.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_002350080.1 conserved hypothetical protein YP_002350081.1 dead/deah box ATP dependent helicase YP_002350082.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_002350083.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002350086.1 transcriptional regulator ZurR (Zinc uptake regulator) YP_002350090.1 conserved hypothetical protein YP_002350094.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive YP_002350095.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002350098.1 conserved hypothetical protein YP_002350100.1 conserved hypothetical protein YP_002350104.1 glycine betaine/carnitine/choline-binding protein (Osmoprotectant-binding protein) YP_002350105.1 glycine betaine/carnitine/choline transport system permeaseopuCD YP_002350106.1 nramp family mn2+/fe2+ transporters YP_002350107.1 conserved hypothetical protein YP_002350110.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002350111.1 conserved integral membrane protein YP_002350116.1 acetyl-CoA acetyltransferase (Acetoacetyl-CoA thiolase) YP_002350118.1 conserved hypothetical protein YP_002350120.1 transcription regulator, Cro/CI family -related protein YP_002350121.1 conserved hypothetical protein YP_002350124.1 pyruvate formate-lyase 1-activating enzyme YP_002350127.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002350128.1 This protein performs the mismatch recognition step during the DNA repair process YP_002350129.1 YmcA YP_002350130.1 conserved hypothetical protein YP_002350131.1 acetyltransferase, gnat family YP_002350132.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_002350133.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002350134.1 competence/damage-inducible protein CinA N- domain YP_002350136.1 conserved DNA-binding domain protein YP_002350137.1 3-ketoacyl-acyl carrier protein reductase YP_002350144.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002350147.1 conserved hypothetical protein YP_002350148.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_002350149.1 conserved hypothetical protein YP_002350150.1 catalyzes the hydrolysis of acylphosphate YP_002350151.1 conserved hypothetical protein YP_002350152.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site YP_002350155.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002350156.1 conserved hypothetical protein YP_002350157.1 conserved hypothetical protein YP_002350158.1 E2; Dihydrolipoamide branched chaintransacylase YP_002350159.1 2-oxoisovalerate dehydrogenase subunit beta (branched-chain alpha-keto acid dehydrogenase e1 component beta chain) (bckdhe1-beta) YP_002350160.1 2-oxoisovalerate dehydrogenase subunit alpha (branched-chain alpha-keto acid dehydrogenase e1 component alpha chain) (bckdhe1-alpha) YP_002350161.1 E3 component of the branched-chain alpha-keto acid dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002350162.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_002350165.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002350167.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002350168.1 conserved domain protein YP_002350169.1 geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) YP_002350170.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002350171.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002350172.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002350173.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002350174.1 conserved protein YqhY YP_002350175.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002350177.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002350179.1 YqhQ YP_002350180.1 conserved hypothetical protein YP_002350181.1 conserved hypothetical protein YP_002350182.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_002350183.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_002350184.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002350190.1 conserved hypothetical protein YP_002350191.1 conserved hypothetical protein YP_002350193.1 glucokinase (Glucose kinase) YP_002350194.1 conserved hypothetical protein YP_002350197.1 conserved hypothetical protein YP_002350198.1 conserved hypothetical protein YP_002350200.1 polyribonucleotide nucleotidyltransferase (Polynucleotidephosphorylase) (PNPase) (Vegetative protein 15) (VEG15) YP_002350201.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002350203.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002350204.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002350205.1 YlxP YP_002350206.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002350208.1 YlxR YP_002350209.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002350210.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002350211.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_002350212.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002350214.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002350216.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002350217.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002350218.1 Catalyzes the phosphorylation of UMP to UDP YP_002350219.1 conserved hypothetical protein YP_002350222.1 ParB-like nuclease domain YP_002350224.1 conserved hypothetical protein YP_002350225.1 conserved domain protein YP_002350227.1 conserved domain protein YP_002350228.1 conserved hypothetical protein YP_002350229.1 Represses a number of genes involved in the response to DNA damage YP_002350230.1 acetyltransferase, gnat family YP_002350238.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002350242.1 lpxtg-motif cell wall anchor domain protein YP_002350244.1 lpxtg-motif cell wall anchor domain protein YP_002350247.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002350248.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002350249.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002350250.1 CoA-binding domain protein YP_002350251.1 conserved hypothetical protein YP_002350253.1 conserved protein YneQ YP_002350254.1 4-hydroxybenzoyl-CoA thioesterase family protein YP_002350255.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_002350256.1 heat shock protein involved in degradation of misfolded proteins YP_002350257.1 heat shock protein involved in degradation of misfolded proteins YP_002350259.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_002350260.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002350262.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002350263.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_002350267.1 binds and unfolds substrates as part of the ClpXP protease YP_002350268.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002350269.1 conserved hypothetical protein YP_002350270.1 helix-turn-helix domain protein YP_002350271.1 membrane protein YP_002350272.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002350273.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002350274.1 hydrolase, alpha/beta fold family YP_002350275.1 conserved hypothetical protein YP_002350280.1 conserved hypothetical protein YP_002350281.1 conserved hypothetical protein YP_002350282.1 conserved hypothetical protein YP_002350285.1 conserved hypothetical protein YP_002350287.1 conserved hypothetical protein YP_002350289.1 conserved hypothetical protein YP_002350291.1 3-demethylubiquinone-9 3-methyltransferase domain protein YP_002350292.1 conserved hypothetical protein YP_002350293.1 conserved hypothetical protein YP_002350295.1 conserved hypothetical protein YP_002350300.1 Cna B domain protein YP_002350301.1 Cna B domain protein YP_002350304.1 conserved hypothetical protein YP_002350315.1 conserved hypothetical protein YP_002350319.1 conserved domain protein YP_002350322.1 Tmp YP_002350323.1 Tmp YP_002350324.1 conserved domain protein YP_002350326.1 Tsh YP_002350328.1 listeria phage, gp9 YP_002350330.1 conserved hypothetical protein YP_002350331.1 conserved domain protein YP_002350332.1 Cps YP_002350333.1 Clp protease domain protein YP_002350338.1 conserved hypothetical protein YP_002350342.1 conserved hypothetical protein YP_002350343.1 phage/plasmid primase, P4 family YP_002350349.1 conserved domain protein YP_002350350.1 conserved domain protein YP_002350352.1 conserved domain protein YP_002350353.1 conserved domain protein YP_002350355.1 phenylalanyl-tRNA synthetase, beta subunit YP_002350356.1 conserved hypothetical protein YP_002350358.1 conserved hypothetical protein YP_002350359.1 conserved hypothetical protein YP_002350360.1 conserved hypothetical protein YP_002350361.1 similar to cytosine-specific methyltransferase NlaX (M.NlaX) YP_002350362.1 conserved hypothetical protein YP_002350363.1 conserved domain protein YP_002350364.1 conserved domain protein YP_002350366.1 conserved domain protein YP_002350367.1 conserved hypothetical protein YP_002350369.1 conserved hypothetical protein YP_002350373.1 hydrolyzes non-standard nucleotides such as xanthine and inosine YP_002350374.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002350375.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002350376.1 conserved protein YslB YP_002350377.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation. YP_002350378.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002350380.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_002350381.1 DNA polymerase X family protein YP_002350383.1 YshA YP_002350384.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002350385.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002350389.1 macrolide export ATP-binding/permease MacB YP_002350390.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002350391.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002350393.1 conserved hypothetical protein YP_002350396.1 N-acetylmuramoyl-L-alanine amidase, family 4 YP_002350397.1 Exo-glucosaminidase LytG (Exo-beta-N-acetylglucosaminidase lytG) (Peptidoglycan hydrolase lytG) (AutolysinlytG) YP_002350398.1 conserved hypothetical protein YP_002350402.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_002350405.1 periplasmic cobalt binding component of the cobalt transport system YP_002350406.1 catalyzes the ATP-dependent transport of cobalt YP_002350407.1 catalyzes the formation of precorrin-3A from precorrin-2 YP_002350411.1 precorrin-3B C17-methyltransferase YP_002350412.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_002350413.1 precorrin-4 C11-methyltransferase YP_002350414.1 catalyzes the methylation of either C-15 or C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W; decarboxylating YP_002350415.1 catalyzes the methylation of C-5 in cobalt-precorrin-6Y to form cobalt-precorrin-7W-a YP_002350416.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_002350417.1 catalyzes the interconversion of cobalt-precorrin-8X and cobyrinic acid in the anaerobic biosynthesis of cobalamin YP_002350418.1 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group YP_002350419.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_002350420.1 conserved hypothetical protein YP_002350423.1 ethanolamine utilization protein EutH ( ethanolaminetransporter) YP_002350424.1 ethanolamine utilization protein, PduT homolog YP_002350430.1 acetaldehyde dehydrogenase (acetylating) YP_002350433.1 catalyzes the formation of acetaldehyde from ethanolamine YP_002350435.1 ethanolamine utilization protein EutA YP_002350440.1 cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase YP_002350445.1 PduO YP_002350454.1 propanediol utilization: dehydratase, small subunit YP_002350463.1 conserved hypothetical protein YP_002350468.1 siroheme synthase subunit family protein YP_002350470.1 conserved hypothetical protein YP_002350471.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002350472.1 conserved hypothetical protein YP_002350474.1 conserved hypothetical protein YP_002350475.1 conserved hypothetical protein YP_002350476.1 conserved hypothetical protein YP_002350477.1 conserved hypothetical protein YP_002350479.1 antibiotic biosynthesis monooxygenase domain protein YP_002350483.1 acetyltransferase, gnat family YP_002350485.1 acetyltransferase, gnat family YP_002350486.1 conserved hypothetical protein YP_002350487.1 conserved hypothetical protein YP_002350489.1 conserved hypothetical protein YP_002350495.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002350498.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002350499.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_002350501.1 CDP-glycerol:glycerophosphate glycerophosphotransferase (Major teichoic acid biosynthesis protein B) YP_002350502.1 cdp-glycerol:poly(glycerophosphate) glycerophosphotransFerase (polyglycerol phosphate polymerase) (cgptase) (majorteichoic acid biosynthesis protein f) YP_002350503.1 glycosyl transferase, group 2 family protein YP_002350504.1 alcohol dehydrogenase, zinc-containing YP_002350505.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002350506.1 glycosyl transferase, group 2 family protein YP_002350508.1 conserved hypothetical protein YP_002350509.1 conserved hypothetical protein YP_002350512.1 conserved hypothetical protein YP_002350516.1 biotin-containing enzyme that catalyzes a two step carboxylation of pyruvate to oxaloacetate YP_002350517.1 cell division protein, FtsW/RodA/SpoVE family YP_002350519.1 depletion of this protein in Bacillus subtilis results in defects in cell morphology; crystal structure of Staphylococcus protein shows homodimer; ligand binding protein YP_002350520.1 conserved hypothetical protein YP_002350521.1 conserved hypothetical protein YP_002350524.1 YktB YP_002350527.1 conserved hypothetical protein YP_002350529.1 conserved hypothetical protein YP_002350530.1 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002350531.1 dihydrolipoyllysine-residue acetyltransferase component of pyruvatedehydrogenase complex (E2) (Dihydrolipoamideacetyltransferase component of pyruvate dehydrogenase complex) YP_002350534.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002350535.1 conserved hypothetical protein YP_002350538.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002350539.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002350540.1 molybdopterin converting factor, subunit 1 YP_002350541.1 molybdopterin converting factor, subunit 2 YP_002350542.1 molybdopterin-guanine dinucleotide biosynthesis protein B YP_002350544.1 molybdate ABC transporter periplasmic molybdate-binding protein YP_002350547.1 molybdopterin-guanine dinucleotide biosynthesis protein A YP_002350548.1 conserved membrane protein YoaT YP_002350550.1 conserved domain protein YP_002350553.1 conserved hypothetical protein YP_002350554.1 conserved hypothetical protein YP_002350556.1 transcriptional regulatory protein DegU (Protease production enhancerprotein) YP_002350558.1 conserved hypothetical protein YP_002350561.1 glucose-specific phosphotransferase enzyme iia component (PTS system glucose-specific eiia component) (eiia-glc) (eiii-glc) YP_002350564.1 glycine betaine transport ATP-binding protein opuAA (Quaternary-amine-transporting ATPase) YP_002350569.1 CBS domain protein YP_002350570.1 YkuJ YP_002350571.1 conserved hypothetical protein YP_002350572.1 aspartate aminotransferase (Transaminase A) (ASPAT) YP_002350573.1 2-hydroxy-3-oxopropionate reductase (tartronatesemialdehyde reductase) (tsar) YP_002350576.1 phosphocarrier protein HPr (Histidine-containing protein) YP_002350577.1 conserved hypothetical protein YP_002350579.1 membrane protein YP_002350582.1 methylated-dna--protein-cysteine methyltransferase (6-o-methylguanine-dna methyltransferase) (mgmt) (o-6-methylguanine-dna-alkyltransferase) YP_002350584.1 conserved hypothetical protein YP_002350590.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002350593.1 conserved hypothetical protein YP_002350595.1 peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) YP_002350597.1 drug resistance transporter EmrB/QacA family YP_002350600.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002350602.1 acetyltransferase, gnat family YP_002350603.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002350604.1 conserved hypothetical protein YP_002350605.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_002350607.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_002350609.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002350610.1 pseudouridine synthase, RluA family YP_002350611.1 catalyzes the phosphorylation of NAD to NADP YP_002350612.1 RelA/SpoT domain protein YP_002350613.1 TPR domain protein YP_002350615.1 metalloprotease YP_002350619.1 undecaprenyl-phosphate N-acetylglucosaminyl 1-phosphatetransferase (UDP-GlcNAc:undecaprenyl-P GlcNAc 1-Ptransferase) YP_002350623.1 conserved hypothetical protein YP_002350624.1 conserved hypothetical protein YP_002350626.1 conserved hypothetical protein YP_002350627.1 conserved hypothetical protein YP_002350628.1 conserved hypothetical protein YP_002350629.1 conserved integral membrane protein YP_002350632.1 conserved hypothetical protein YP_002350634.1 conserved protein YneR YP_002350635.1 General stress protein 20U (GSP20U) (DPS protein homolog) YP_002350636.1 histidine kinase domain protein YP_002350637.1 conserved hypothetical protein YP_002350638.1 conserved hypothetical protein YP_002350643.1 RNA methyltransferase, TrmH family, group 2 YP_002350646.1 membrane protein, DedA family YP_002350650.1 responsible for recognizing base lesions in the genome and initiating base excision DNA repair YP_002350651.1 glycerol phosphate lipoteichoic acid synthase 1 (LTAsynthase 1) (Polyglycerol phosphate synthase 1) YP_002350655.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002350656.1 YcgQ YP_002350657.1 YcgR YP_002350660.1 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002350661.1 PTS system, beta-glucoside-specific, IIA component YP_002350662.1 PTS system, IIC component YP_002350663.1 PTS system, cellobiose-specific, IIB component YP_002350666.1 bacterial transcription activator, effector binding domain YP_002350667.1 membrane protein YP_002350671.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002350672.1 conserved hypothetical protein YP_002350674.1 conserved hypothetical protein YP_002350677.1 PTS system, cellobiose-specific IIC component YP_002350678.1 conserved hypothetical protein YP_002350679.1 similar to protein T24A6.7 YP_002350680.1 conserved hypothetical protein YP_002350682.1 conserved SprT family protein YP_002350683.1 conserved hypothetical protein YP_002350685.1 indirect negative regulation of sigma B dependant gene expression YP_002350686.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma B is not essential for sporulation; rather it is required for maximal expression of ctc and csbA which are transcribed in the early stationary phase under conditions inimical to sporulation; induced by heat shock, salt stress, oxidative stress, glucose limitation, oxygen limitation and entry into stationary phase YP_002350687.1 binds to sigma-B preventing the formation of an RNA polymerase holoenzyme YP_002350688.1 anti-sigma-B factor antagonist (Anti-anti-sigma-B factor) YP_002350689.1 phosphoserine phosphatase RsbU (Sigma factor sigBregulation protein rsbU) YP_002350690.1 serine/threonine-protein kinase RsbT (Switchprotein/serine kinase) (Anti-sigma-B factor rsbT) YP_002350693.1 endoribonuclease EndoA YP_002350696.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002350697.1 catalyzes the formation of protoporphyrin IX from protoporphyrinogen IX YP_002350698.1 bacterial membrane flanked domain family YP_002350699.1 bacterial membrane flanked domain family YP_002350700.1 conserved hypothetical protein YP_002350701.1 LysM domain protein YP_002350703.1 oxidoreductase, aldo/keto reductase family YP_002350705.1 PTS system, IIc component YP_002350706.1 PTS system, Lactose/Cellobiose specific IIB subunit subfamily YP_002350707.1 lactose-specific phosphotransferase enzyme iia component (PTS system lactose-specific eiia component) (eiia-lac) (eiii-lac) YP_002350708.1 PTS system IIA 2 domain protein YP_002350712.1 conserved hypothetical protein YP_002350716.1 conserved hypothetical protein YP_002350717.1 cold-shock deAd box protein a (atp-dependent rna helicasedead) YP_002350718.1 phosphoglucomutase (Alpha-phosphoglucomutase) (Glucosephosphomutase) (PGM) YP_002350719.1 conserved hypothetical protein YP_002350720.1 conserved hypothetical protein YP_002350724.1 sugar ABC transporter sugar-binding protein YP_002350726.1 hydrolase, alpha/beta fold family YP_002350727.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (UDP-MurNAc-pentapeptide synthetase) (D-alanyl-D-alanine-adding enzyme) YP_002350728.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002350732.1 conserved hypothetical protein YP_002350733.1 conserved hypothetical protein YP_002350737.1 glutamine transport ATP-binding protein GlnQ YP_002350739.1 UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) YP_002350740.1 vitamin-B12 independent methionine synthase family protein YP_002350742.1 conserved hypothetical protein YP_002350743.1 calcium-transporting ATPase 3, endoplasmic reticulum-type YP_002350746.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_002350747.1 lipid A export ATP-binding/permease MsbA YP_002350748.1 membrane protein YP_002350750.1 conserved hypothetical protein YP_002350751.1 conserved hypothetical protein YP_002350752.1 transcriptional activator, Rgg/GadR/MutR family, C- domain YP_002350753.1 transposase subfamily YP_002350758.1 hydroxymethylglutaryl-CoA reductase, degradative YP_002350759.1 conserved hypothetical protein YP_002350760.1 2,5-diketo-d-gluconic acid reductase a (2,5-dkgreductase a) (2,5-dkgr a) (25dkgr-a) (akr5c) YP_002350763.1 acetyltransferase, gnat family YP_002350764.1 conserved hypothetical protein YP_002350770.1 HD domain protein YP_002350779.1 ABC transporter spermidine/putrescine binding protein YP_002350782.1 spermidine/putrescine import ATP-binding protein PotA YP_002350784.1 conserved hypothetical protein YP_002350785.1 conserved hypothetical protein YP_002350787.1 conserved hypothetical protein YP_002350788.1 conserved hypothetical protein YP_002350794.1 YwnB YP_002350795.1 membrane protein YP_002350796.1 hydrolase, carbon-nitrogen family YP_002350798.1 YbaK/ebsC protein YP_002350799.1 phenazine biosynthesis protein, PhzF family YP_002350800.1 CoA-substrate-specific enzyme activase domain protein YP_002350802.1 fmn-dependent NADH-azoreductase 2 (fmn-dependent nadh-azocompound oxidoreductase 2) (azo-dye reductase 2) YP_002350804.1 conserved hypothetical protein YP_002350805.1 PTS system mannose-specific eiiab component (eiiab-man) YP_002350806.1 fructose-specific phosphotransferase enzyme iib component (PTS system fructose-specific eiib component) (eiib-fru)(p18) YP_002350807.1 fructose permease iic component (PTS system fructose-specific eiiccomponent) (eiic-fru) (p28) YP_002350808.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_002350810.1 conserved hypothetical protein YP_002350811.1 similar to membrane protein Lmo0779 YP_002350812.1 conserved hypothetical protein YP_002350814.1 conserved hypothetical protein YP_002350815.1 conserved hypothetical protein YP_002350818.1 conserved hypothetical protein YP_002350820.1 Ser/Thr protein phosphatase family protein YP_002350822.1 conserved hypothetical protein YP_002350823.1 esterase family protein YP_002350826.1 bacitracin transport permease BcrB YP_002350827.1 bacitracin transport ATP-binding protein BcrA YP_002350828.1 lipolytic protein G-D-S-L family YP_002350829.1 conserved hypothetical protein YP_002350831.1 hydrolase, alpha/beta fold family YP_002350832.1 conserved hypothetical protein YP_002350833.1 conserved hypothetical protein YP_002350834.1 conserved domain protein YP_002350835.1 conserved hypothetical protein YP_002350836.1 conserved hypothetical protein YP_002350837.1 conserved hypothetical protein YP_002350838.1 conserved hypothetical protein YP_002350840.1 membrane protein YP_002350843.1 cyclic nucleotide-binding domain protein YP_002350847.1 conserved hypothetical protein YP_002350848.1 conserved hypothetical protein YP_002350849.1 conserved hypothetical protein YP_002350851.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002350853.1 conserved domain protein YP_002350854.1 conserved hypothetical protein YP_002350857.1 catalyzes the formation of acetyl phosphate from pyruvate YP_002350859.1 conserved hypothetical protein YP_002350862.1 conserved hypothetical protein YP_002350863.1 transglycosylase, SLT family YP_002350864.1 involved in type III protein export during flagellum assembly YP_002350865.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002350866.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002350867.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002350868.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002350869.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002350870.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod YP_002350871.1 conserved hypothetical protein YP_002350873.1 involved in flagellin assembly YP_002350874.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_002350875.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002350876.1 conserved hypothetical protein YP_002350877.1 conserved hypothetical protein YP_002350878.1 conserved hypothetical protein YP_002350879.1 conserved hypothetical protein YP_002350880.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002350881.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002350882.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002350883.1 the hook connects flagellar basal body to the flagellar filament YP_002350884.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod YP_002350885.1 conserved hypothetical protein YP_002350886.1 conserved hypothetical protein YP_002350887.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002350890.1 structural flagella protein YP_002350892.1 glycosyl transferase, group 2 family protein YP_002350893.1 conserved hypothetical protein YP_002350894.1 chemotaxis protein MotB (Motility protein B) YP_002350895.1 With Mot B forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine. YP_002350896.1 conserved hypothetical protein YP_002350897.1 CheR methyltransferase, SAM binding domain YP_002350898.1 makes up the distal portion of the flagellar basal body rod YP_002350899.1 Positive regulator of class III flagellar genes YP_002350900.1 membrane protein involved in the flagellar export apparatus YP_002350901.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002350902.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002350903.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_002350904.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002350905.1 conserved hypothetical protein YP_002350907.1 conserved hypothetical protein YP_002350908.1 conserved hypothetical protein YP_002350910.1 conserved hypothetical protein YP_002350911.1 conserved hypothetical protein YP_002350912.1 conserved hypothetical protein YP_002350913.1 conserved domain protein YP_002350914.1 general stress protein 39 (GSP39) YP_002350915.1 conserved hypothetical protein YP_002350918.1 YwdK YP_002350919.1 conserved hypothetical protein YP_002350920.1 maltose O-acetyltransferase (Maltose transacetylase) YP_002350924.1 carboxymuconolactone decarboxylase family protein YP_002350928.1 endonuclease III domain protein YP_002350929.1 conserved hypothetical protein YP_002350930.1 conserved hypothetical protein YP_002350931.1 serine/threonine protein phosphatase family protein YP_002350932.1 conserved hypothetical protein YP_002350933.1 conserved hypothetical protein YP_002350934.1 acetyltransferase, gnat family YP_002350939.1 conserved hypothetical protein YP_002350944.1 membrane protein YP_002350948.1 conserved hypothetical protein YP_002350949.1 conserved hypothetical protein YP_002350950.1 conserved hypothetical protein YP_002350951.1 methyltransferase, UbiE/COQ5 family YP_002350953.1 HAD-superfamily hydrolase, subfamily IA, variant 1 YP_002350954.1 hydrolase, isochorismatase family YP_002350955.1 conserved hypothetical protein YP_002350957.1 membrane protein YP_002350959.1 acetyltransferase, gnat family YP_002350960.1 conserved hypothetical protein YP_002350961.1 conserved hypothetical protein YP_002350962.1 domain of unknown function YP_002350964.1 conserved hypothetical protein YP_002350967.1 conserved domain protein YP_002350968.1 conserved hypothetical protein YP_002350969.1 alcohol dehydrogenase, zinc-dependent YP_002350971.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002350972.1 lpxtg-motif cell wall anchor domain protein YP_002350973.1 rhodanese domain protein YP_002350978.1 conserved hypothetical protein YP_002350979.1 conserved hypothetical protein YP_002350980.1 acetyltransferase, gnat family YP_002350981.1 conserved hypothetical protein YP_002350982.1 conserved hypothetical protein YP_002350985.1 cyclic nucleotide-binding domain protein YP_002350987.1 membrane protein YP_002350989.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine YP_002350992.1 conserved hypothetical protein YP_002350994.1 DAK2 domain protein YP_002350995.1 conserved hypothetical protein YP_002350997.1 conserved hypothetical protein YP_002350999.1 secreted protein YP_002351001.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins YP_002351002.1 iap; p60; autolytic enzyme; can cleave bacterial peptidoglycan; secreted by SecA2 system YP_002351005.1 conserved domain protein YP_002351010.1 glycosyl hydrolase, family 1 YP_002351012.1 conserved hypothetical protein YP_002351013.1 methylated-DNA-protein-cysteine methyltransferase YP_002351014.1 catalyzes the formation of L-histidinol from L-histidinol phosphate YP_002351015.1 May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine YP_002351016.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_002351017.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002351018.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_002351019.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002351020.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002351021.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002351022.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_002351023.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_002351024.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002351031.1 CBS domain protein YP_002351033.1 conserved hypothetical protein YP_002351036.1 cyclic nucleotide-binding domain protein YP_002351039.1 glucitol operon activator domain protein YP_002351040.1 glucitol/sorbitol permease iic component (PTS systemglucitol/sorbitol-specific eiic component) (eiic-gut) YP_002351041.1 glucitol/sorbitol-specific phosphotransferase enzyme iib component (PTS system glucitol/sorbitol-specific eiib component)(eii-gut) YP_002351042.1 PTS system, glucitol/sorbitol-specific, IIA component YP_002351045.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources YP_002351047.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002351048.1 6-phospho-beta-glucosidase (Cellobiose-6-phosphatehydrolase) (Phospho-chitobiase) YP_002351050.1 conserved hypothetical protein YP_002351051.1 ACT domain-containing protein YP_002351052.1 conserved hypothetical protein YP_002351054.1 ggdef motif membrane protein YP_002351055.1 conserved hypothetical protein YP_002351056.1 glycosyl transferase, group 2 family protein YP_002351057.1 conserved hypothetical protein YP_002351061.1 conserved hypothetical protein YP_002351063.1 6-phospho-beta-glucosidase (Cellobiose-6-phosphatehydrolase) (Phospho-chitobiase) YP_002351064.1 conserved hypothetical protein YP_002351075.1 CapA domain protein YP_002351079.1 conserved hypothetical protein YP_002351080.1 glutamine amidotransferase, class I YP_002351083.1 ribose-Phosphate pyrophosphokinase (rppk) (phosphoribosylpyrophosphate synthetase) (p-rib-pp synthetase) (prpp synthetase) YP_002351085.1 PTS system, galactitol-specific, IIB component YP_002351086.1 alcohol dehydrogenase, zinc-dependent YP_002351088.1 conserved hypothetical protein YP_002351089.1 PTS system, IIA component YP_002351090.1 SIS domain protein YP_002351095.1 conserved domain protein YP_002351096.1 integral membrane protein DUF6 YP_002351098.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002351099.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002351103.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002351106.1 conserved hypothetical protein YP_002351108.1 conserved hypothetical protein YP_002351109.1 conserved hypothetical protein YP_002351110.1 iron regulated; catalyzes the release of heme from hemoglobin allowing bacterial pathogens to use the host heme as an iron source YP_002351112.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002351113.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_002351115.1 HD domain protein YP_002351118.1 conserved hypothetical protein YP_002351119.1 conserved hypothetical protein YP_002351124.1 conserved hypothetical protein YP_002351126.1 conserved hypothetical protein YP_002351127.1 magnesium chelatase, subunit ChII family protein YP_002351128.1 protein of unknown function YP_002351129.1 membrane protein YP_002351130.1 conserved hypothetical protein YP_002351131.1 membrane protein YP_002351132.1 membrane protein YP_002351133.1 conserved hypothetical protein YP_002351135.1 conserved hypothetical protein YP_002351137.1 conserved hypothetical protein YP_002351138.1 conserved hypothetical protein YP_002351141.1 conserved hypothetical protein YP_002351143.1 transcription regulator YP_002351148.1 conserved hypothetical protein YP_002351150.1 conserved hypothetical protein YP_002351151.1 conserved hypothetical protein YP_002351152.1 conserved hypothetical protein YP_002351153.1 conserved hypothetical protein YP_002351159.1 acetyltransferase, CysE/LacA/LpxA/NodL family YP_002351161.1 conserved hypothetical protein YP_002351162.1 glycosyl hydrolase, family 38 YP_002351168.1 part of sigC operon induced by temperature upshift YP_002351169.1 part of sigC operon that is induced by temperature upshift YP_002351170.1 membrane protein YP_002351172.1 conserved hypothetical protein YP_002351173.1 conserved hypothetical protein YP_002351174.1 conserved domain protein YP_002351177.1 conserved hypothetical protein YP_002351178.1 conserved hypothetical protein YP_002351180.1 conserved hypothetical protein YP_002351181.1 conserved hypothetical protein YP_002351184.1 conserved hypothetical protein YP_002351185.1 conserved hypothetical protein YP_002351187.1 glycosyl hydrolase, family 38 YP_002351188.1 PTS system; fructose-specific II component YP_002351189.1 PTS system; fructose-specific IIB component YP_002351190.1 PTS system, fructose-specific, IIA component YP_002351191.1 conserved hypothetical protein YP_002351192.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002351193.1 acetyltransferase, gnat family YP_002351195.1 conserved hypothetical protein YP_002351196.1 similar to protein Lmo0392 YP_002351197.1 conserved hypothetical protein YP_002351198.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002351200.1 conserved hypothetical protein YP_002351201.1 conserved hypothetical protein YP_002351205.1 methylmalonate-semialdehyde dehydrogenase (acylating) YP_002351207.1 conserved hypothetical protein YP_002351208.1 conserved hypothetical protein YP_002351209.1 conserved hypothetical protein YP_002351210.1 conserved hypothetical protein YP_002351211.1 conserved hypothetical protein YP_002351212.1 HTH domain family YP_002351213.1 conserved hypothetical protein YP_002351214.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002351215.1 PTS system, beta-glucoside-specific, IIC component YP_002351216.1 glycosyl hydrolase, family 1 YP_002351219.1 conserved hypothetical protein YP_002351223.1 conserved hypothetical protein YP_002351225.1 fructose-bisphosphate aldolase YP_002351227.1 PTS system, fructose-specific IIA component YP_002351230.1 Reduces fumarate to succinate in anaerobic bacterial respiration YP_002351233.1 acetyltransferase, gnat family YP_002351235.1 dihydroxyacetone kinase, phosphotransfer subunit YP_002351236.1 conserved hypothetical protein YP_002351237.1 conserved hypothetical protein YP_002351238.1 PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-bindingsubunit DhaK YP_002351239.1 dihydroxyacetone kinase, L subunit YP_002351243.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002351245.1 conserved hypothetical protein YP_002351248.1 conserved hypothetical protein YP_002351249.1 conserved hypothetical protein YP_002351250.1 conserved hypothetical protein YP_002351251.1 conserved hypothetical protein YP_002351252.1 conserved hypothetical protein YP_002351254.1 IspD YP_002351255.1 IspD YP_002351257.1 conserved hypothetical protein YP_002351258.1 leucine rich repeat domain/ lpxtg-motif cell wall anchor domain protein YP_002351260.1 transcriptional activator, Rgg/GadR/MutR family, C- domain YP_002351263.1 conserved hypothetical protein YP_002351264.1 membrane protein YP_002351265.1 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002351266.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_002351268.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_002351270.1 conserved hypothetical protein YP_002351271.1 similar to modification methylase HaeIII (Cytosine-specific methyltransferase HaeIII) (M.HaeIII) YP_002351273.1 protein of unknown function YP_002351274.1 conserved hypothetical protein YP_002351275.1 conserved hypothetical protein YP_002351276.1 conserved hypothetical protein YP_002351280.1 PTS system, beta-glucoside-specific, IIA component YP_002351281.1 6-phospho-beta-galactosidase (beta-d-phosphogalactosidegalactohydrolase) (pgalase) (p-beta-gal) (pbg) YP_002351283.1 PTS system, IIC component YP_002351285.1 membrane protein YP_002351286.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002351291.1 YycH protein YP_002351292.1 YycH protein YP_002351295.1 produces methionine from 2-keto-4-methylthiobutyrate and glutamine in vitro; mutations do not affect methionine salvage in vivo however YP_002351299.1 hydrolase, carbon-nitrogen family YP_002351302.1 membrane protein YP_002351305.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002351308.1 conserved hypothetical protein YP_002351309.1 metallo-beta-lactamase domain protein YP_002351310.1 conserved hypothetical protein YP_002351311.1 acetyltransferase, gnat family YP_002351313.1 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002351314.1 conserved hypothetical protein YP_002351320.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002351321.1 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002351322.1 conserved hypothetical protein YP_002351323.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002351324.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002351325.1 conserved hypothetical protein YP_002351327.1 oligo-1,6-glucosidase (Oligosaccharide alpha-1,6-glucosidase) (Sucrase-isomaltase) (Isomaltase) (Dextrin 6-alpha-D-glucanohydrolase) YP_002351332.1 conserved hypothetical protein YP_002351333.1 conserved hypothetical protein YP_002351335.1 methyltransferase small domain superfamily YP_002351337.1 conserved hypothetical protein YP_002351339.1 transcriptional regulator, BlaI/MecI/CopY family YP_002351340.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002351341.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002351342.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002351343.1 binds directly to 23S ribosomal RNA YP_002351344.1 conserved hypothetical protein YP_002351345.1 Modulates Rho-dependent transcription termination YP_002351346.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002351347.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_002351348.1 YacP YP_002351349.1 RNA methyltransferase, TrmH family, group 3 YP_002351351.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002351354.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002351355.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002351356.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002351357.1 pin/tram domain protein YP_002351358.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002351363.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002351364.1 transcriptional regulator involved in nitrogen regulation YP_002351370.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002351371.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_002351374.1 S1 family RNA-binding protein YP_002351379.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002351380.1 acetyltransferase, gnat family YP_002351381.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002351382.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH YP_002351383.1 conserved hypothetical protein YP_002351386.1 conserved hypothetical protein YP_002351389.1 Staphylococcus aureus neutral proteinase YP_002351390.1 Hly YP_002351391.1 1-phosphatidylinositol phosphodiesterase (Phosphatidylinositol diacylglycerol-lyase) (Phosphatidylinositol-specific phospholipase C) (PI-PLC) YP_002351393.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002351394.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002351395.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_002351396.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_002351397.1 macrolide export ATP-binding/permease MacB YP_002351398.1 macrolide export ATP-binding/permease MacB YP_002351399.1 conserved hypothetical protein YP_002351401.1 conserved hypothetical protein YP_002351402.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002351404.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002351405.1 primase homolog YP_002351406.1 YabE YP_002351407.1 hydrolase, TatD family YP_002351408.1 oligo-1,6-glucosidase (Oligosaccharide alpha-1,6-glucosidase) (Sucrase-isomaltase) (Isomaltase) (Dextrin 6-alpha-D-glucanohydrolase) YP_002351409.1 alpha-glucosidase 2 (Alpha-glucosidase II) YP_002351410.1 glycosyl hydrolase, family 31 YP_002351413.1 binding-protein-dependent transport systems inner membrane component YP_002351415.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002351418.1 conserved hypothetical protein YP_002351421.1 conserved hypothetical protein YP_002351422.1 GIY-YIG domain protein YP_002351423.1 methyltransferase small domain protein YP_002351424.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_002351426.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002351436.1 bacterial extracellular solute-binding protein, family 5 YP_002351437.1 conserved hypothetical protein YP_002351438.1 conserved hypothetical protein YP_002351439.1 conserved hypothetical protein YP_002351440.1 conserved hypothetical protein YP_002351441.1 conserved hypothetical protein YP_002351442.1 conserved hypothetical protein YP_002351443.1 conserved hypothetical protein YP_002351444.1 conserved hypothetical protein YP_002351445.1 conserved hypothetical protein YP_002351450.1 acetyltransferase, gnat family YP_002351451.1 conserved domain protein YP_002351453.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002351454.1 EAL domain protein YP_002351461.1 helix-turn-helix domain protein YP_002351464.1 EAL domain protein YP_002351472.1 conserved hypothetical protein YP_002351477.1 conserved hypothetical protein YP_002351478.1 conserved hypothetical protein YP_002351479.1 fructose permease iid component (PTS system fructose-specific eiidcomponent) (eiid-fru) (p30) YP_002351480.1 fructose permease iic component (PTS system fructose-specific eiiccomponent) (eiic-fru) (p28) YP_002351482.1 conserved hypothetical protein YP_002351484.1 conserved hypothetical protein YP_002351485.1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain YP_002351486.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the beta chain is a regulatory subunit YP_002351487.1 ATP synthase F1, gamma subunit YP_002351488.1 produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a catalytic subunit YP_002351489.1 conserved hypothetical protein YP_002351491.1 conserved hypothetical protein YP_002351492.1 conserved hypothetical protein YP_002351493.1 conserved hypothetical protein YP_002351497.1 conserved domain protein YP_002351500.1 N-acetylmuramoyl-L-alanine amidase domain protein YP_002351501.1 conserved hypothetical protein YP_002351514.1 conserved hypothetical protein YP_002351527.1 conserved domain protein YP_002351528.1 conserved hypothetical protein YP_002351532.1 conserved hypothetical protein YP_002351536.1 conserved phage-associated protein YP_002351537.1 conserved phage-associated protein YP_002351545.1 conserved domain protein YP_002351546.1 helix-turn-helix domain protein YP_002351548.1 Int YP_002351558.1 conserved hypothetical protein YP_002351560.1 conserved hypothetical protein YP_002351561.1 membrane protein YP_002351562.1 conserved hypothetical protein YP_002351563.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002351564.1 conserved hypothetical protein YP_002351565.1 unwinds double stranded DNA YP_002351566.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002351568.1 2-components response regulator protein, AlgR/VirR/ComE type YP_002351569.1 conserved hypothetical protein YP_002351570.1 conserved hypothetical protein YP_002351571.1 essential for production of a quorum sensing autoinducing peptide YP_002351573.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002351575.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002351576.1 catalyzes the degradation of arginine to citruline and ammonia YP_002351577.1 membrane protein, DedA family YP_002351578.1 SIS domain protein YP_002351579.1 PTS system, beta-glucoside-specific, IIC component YP_002351580.1 glycosyl hydrolase, family 9 YP_002351583.1 conserved hypothetical protein YP_002351584.1 conserved hypothetical protein YP_002351588.1 conserved hypothetical protein YP_002351589.1 PTS system, mannose/fructose/sorbose family, IID component YP_002351590.1 PTS system, mannose/fructose/sorbose family, IIC component YP_002351591.1 PTS system, mannose/fructose/sorbose family, IIB component YP_002351592.1 PTS system, fructose-specific, IIA component YP_002351594.1 bacterial SH3 domain family YP_002351595.1 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002351596.1 cytochrome aa3 quinol oxidase, subunit IV YP_002351597.1 cytochrome aa3 quinol oxidase, subunit III YP_002351598.1 cytochrome aa3 quinol oxidase, subunit I YP_002351603.1 conserved hypothetical protein YP_002351605.1 cardiolipin synthetase (Cardiolipin synthase) (CLsynthase) YP_002351606.1 DNA gyrase, A subunit YP_002351607.1 DNA gyrase, B subunit YP_002351608.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002351609.1 S4 domain protein YaaA YP_002351611.1 binds the polymerase to DNA and acts as a sliding clamp YP_002351612.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002351613.1 conserved hypothetical protein YP_002351614.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002351615.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002351622.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_002351627.1 conserved hypothetical protein YP_002351628.1 conserved hypothetical protein YP_002351642.1 conserved hypothetical protein YP_002351645.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002351647.1 conserved hypothetical protein YP_002351648.1 conserved hypothetical protein YP_002351649.1 conserved hypothetical protein YP_002351650.1 amino- domain YP_002351655.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002351657.1 conserved hypothetical protein YP_002351658.1 conserved hypothetical protein YP_002351660.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002351661.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002351663.1 conserved hypothetical protein YP_002351664.1 conserved hypothetical protein YP_002351665.1 conserved hypothetical protein YP_002351666.1 conserved hypothetical protein YP_002351667.1 conserved hypothetical protein YP_002351668.1 conserved hypothetical protein YP_002351669.1 conserved hypothetical protein YP_002351670.1 conserved hypothetical protein YP_002351671.1 conserved hypothetical protein YP_002351672.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002351673.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002351677.1 PTS system, IIA component YP_002351685.1 conserved domain protein YP_002351687.1 PRD domain protein YP_002351688.1 PTS system, beta-glucoside-specific, IIC component YP_002351689.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002351691.1 PTS system, beta-glucoside-specific, IIA component YP_002351692.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002351694.1 conserved hypothetical protein YP_002351695.1 conserved hypothetical protein YP_002351699.1 drug resistance transporter Bcr/CflA family YP_002351701.1 macrolide export ATP-binding/permease MacB YP_002351702.1 Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine YP_002351704.1 membrane protein YP_002351705.1 conserved hypothetical protein YP_002351707.1 lichenan-specific phosphotransferase enzyme iia component (PTS system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002351710.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002351712.1 conserved hypothetical protein YP_002351714.1 conserved hypothetical protein YP_002351718.1 decatenates replicating daughter chromosomes YP_002351719.1 hydrolase, CocE/NonD family YP_002351721.1 D-alanyl-D-alanine carboxypeptidase DacA (DD-peptidase) (DD-carboxypeptidase) (CPase) (Penicillin-binding protein5) (PBP-5) YP_002351725.1 conserved hypothetical protein YP_002351733.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002351734.1 TfoX domain protein YP_002351735.1 multidrug resistance ABC transporter ATP-binding and permease YP_002351737.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_002351738.1 SH3 domain protein YP_002351740.1 conserved hypothetical protein YP_002351741.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002351742.1 CBS domain protein YP_002351746.1 glycosyl hydrolase, family 38 YP_002351749.1 conserved hypothetical protein YP_002351750.1 HAD-superfamily hydrolase, subfamily IA, variant 1 YP_002351751.1 cupin 2 conserved barrel domain protein YP_002351756.1 3-demethylubiquinone-9 3-methyltransferase domain protein YP_002351757.1 acetyltransferase, gnat family YP_002351759.1 glucosamine-6-phosphate isomerase YP_002351760.1 acetyl-coenzyme A synthetase (Acetate--CoA ligase) (Acyl-activating enzyme) (Acetyl-CoA synthase) YP_002351763.1 cytochrome D ubiquinol oxidase, subunit II YP_002351764.1 ABC transporter CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD YP_002351765.1 ABC transporter CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC YP_002351769.1 gluconokinase (Gluconate kinase) YP_002351770.1 conserved hypothetical protein YP_002351771.1 conserved hypothetical protein YP_002351772.1 PTS system, cellobiose-specific, IIC component YP_002351773.1 conserved hypothetical protein YP_002351774.1 conserved hypothetical protein YP_002351775.1 conserved hypothetical protein YP_002351777.1 conserved hypothetical protein YP_002351778.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002351779.1 conserved hypothetical protein YP_002351783.1 dihydroxyacetone kinase, phosphotransfer subunit YP_002351784.1 dihydroxyacetone kinase, L subunit YP_002351785.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002351787.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002351788.1 conserved hypothetical protein YP_002351789.1 conserved hypothetical protein YP_002351791.1 cell wall hydrolase; muramidase-2 like protein in Enterococcus faecalis; in Enterococcus faecalis a mutant in this gene has no effect on virulence in mouse models; Listeria monocytogenes MurA in involved in general autolysis; contains an N-terminal muramidase domain and C-terminal LysM repeats for cell wall-anchoring YP_002351794.1 cell division protein, FtsW/RodA/SpoVE family YP_002351795.1 cell division protein, FtsW/RodA/SpoVE family YP_002351796.1 lichenan-specific phosphotransferase enzyme iia component (PTS system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002351797.1 lichenan permease iic component (PTS system lichenan-specific eiiccomponent) (eiic-lic) YP_002351798.1 lichenan-specific phosphotransferase enzyme iib component (PTS system lichenan-specific eiib component) (eiib-lic) YP_002351799.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002351800.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002351801.1 K+-transporting ATPase, C subunit YP_002351804.1 hydrolase, alpha/beta fold family YP_002351806.1 conserved hypothetical protein YP_002351807.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002351809.1 conserved hypothetical protein YP_002351810.1 conserved hypothetical protein YP_002351812.1 PTS system, IIA component YP_002351815.1 alcohol dehydrogenase, zinc-dependent YP_002351821.1 acetyltransferase, gnat family YP_002351822.1 dGTPase family type 3 subfamily, presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_002351823.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002351824.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002351825.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002351826.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002351827.1 transcriptional antiterminator, BglG YP_002351829.1 PTS system, lactose/cellobiose specific IIB subunit YP_002351830.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002351833.1 conserved hypothetical protein YP_002351834.1 conserved hypothetical protein YP_002351836.1 conserved hypothetical protein YP_002351840.1 conserved hypothetical protein YP_002351844.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002351846.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002351847.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002351848.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002351849.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002351850.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002351851.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002351852.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002351853.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002351854.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002351855.1 one of the stabilizing components for the large ribosomal subunit YP_002351856.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002351857.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002351858.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002351859.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002351860.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_002351861.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002351862.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002351863.1 binds 5S rRNA along with protein L5 and L25 YP_002351864.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002351865.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002351866.1 late assembly protein YP_002351867.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002351868.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002351869.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002351870.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002351871.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002351872.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002351873.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002351874.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002351875.1 conserved hypothetical protein YP_002351878.1 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene YP_002351879.1 with CbiNQ forms the ABC transporter for cobalt import; Bacillus spp. have two adjacent copies of this gene YP_002351881.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002351882.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002351883.1 forms a direct contact with the tRNA during translation YP_002351889.1 conserved domain protein YP_002351890.1 similar to gp37 of Listeria phage A118 YP_002351891.1 conserved hypothetical protein YP_002351892.1 conserved hypothetical protein YP_002351893.1 conserved hypothetical protein YP_002351894.1 similar to phage anti-repressor of Bacteriophage A118 YP_002351895.1 similar to gp43 from Bacteriophage A118) YP_002351896.1 conserved hypothetical protein YP_002351897.1 similar to gp45 of Bacteriophage A118 YP_002351898.1 similar to gp47 of Bacteriophage A118 YP_002351900.1 similar to gp49 of Bacteriophage A118 YP_002351901.1 conserved hypothetical protein YP_002351903.1 conserved hypothetical protein YP_002351904.1 conserved hypothetical protein YP_002351905.1 conserved hypothetical protein YP_002351907.1 conserved hypothetical protein YP_002351909.1 conserved hypothetical protein YP_002351911.1 conserved domain protein YP_002351914.1 similar to gp59 from Bacteriophage A118 YP_002351915.1 single-stranded DNA-binding protein (SSB) (Helix-destabilizingprotein) YP_002351917.1 conserved domain protein YP_002351918.1 conserved hypothetical protein YP_002351920.1 conserved domain protein YP_002351921.1 similar to gp65 Bacteriophage A118 YP_002351922.1 similar to hypothetical protein of Bacteriophage A118 YP_002351925.1 phage terminase, large subunit, pbsx family YP_002351927.1 similar to hypothetical protein of Bacteriophage A118 YP_002351928.1 similar to scaffolding protein of Bacteriophage A118 YP_002351930.1 similar to hypothetical protein of Bacteriophage A118 YP_002351932.1 similar to Gp10 of Bacteriophage A118) YP_002351933.1 similar to gp11 Bacteriophage A118 YP_002351934.1 similar to major tail shaft protein of Bacteriophage A118 YP_002351935.1 similar to hypothetical protein of Bacteriophage A118 YP_002351936.1 similar to hypothetical protein of Bacteriophage A118 YP_002351937.1 similar to gp15 of Bacteriophage A118 YP_002351938.1 similar to tape-measure protein of Bacteriophage A118 YP_002351939.1 Protein gp17 (Listeria phage A118) YP_002351940.1 similar to gp18 of Bacteriophage A118 YP_002351941.1 similar to gp19 of Bacteriophage A118 YP_002351942.1 similar to gp20 of Bacteriophage A118 YP_002351943.1 conserved hypothetical protein YP_002351944.1 conserved domain protein YP_002351954.1 N-acetylmuramoyl-L-alanine amidase, family 4