-- dump date   	20140619_132631
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
552536000001	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536000002	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536000003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536000004	putative substrate translocation pore; other site
552536000005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536000006	Uncharacterized conserved protein [Function unknown]; Region: COG1912
552536000007	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
552536000008	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
552536000009	catalytic loop [active]
552536000010	iron binding site [ion binding]; other site
552536000011	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
552536000012	4Fe-4S binding domain; Region: Fer4; pfam00037
552536000013	4Fe-4S binding domain; Region: Fer4; pfam00037
552536000014	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
552536000015	[4Fe-4S] binding site [ion binding]; other site
552536000016	molybdopterin cofactor binding site; other site
552536000017	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
552536000018	molybdopterin cofactor binding site; other site
552536000019	Uncharacterized conserved protein [Function unknown]; Region: COG2427
552536000020	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
552536000021	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536000022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536000023	active site
552536000024	phosphorylation site [posttranslational modification]
552536000025	intermolecular recognition site; other site
552536000026	dimerization interface [polypeptide binding]; other site
552536000027	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536000028	DNA binding site [nucleotide binding]
552536000029	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536000030	dimerization interface [polypeptide binding]; other site
552536000031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536000032	dimer interface [polypeptide binding]; other site
552536000033	phosphorylation site [posttranslational modification]
552536000034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536000035	ATP binding site [chemical binding]; other site
552536000036	Mg2+ binding site [ion binding]; other site
552536000037	G-X-G motif; other site
552536000038	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536000039	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552536000040	FtsX-like permease family; Region: FtsX; pfam02687
552536000041	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536000042	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536000043	Walker A/P-loop; other site
552536000044	ATP binding site [chemical binding]; other site
552536000045	Q-loop/lid; other site
552536000046	ABC transporter signature motif; other site
552536000047	Walker B; other site
552536000048	D-loop; other site
552536000049	H-loop/switch region; other site
552536000050	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000051	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000052	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000053	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000054	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000055	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000056	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000057	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000058	Leucine rich repeat; Region: LRR_8; pfam13855
552536000059	LRR adjacent; Region: LRR_adjacent; pfam08191
552536000060	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
552536000061	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536000062	Uncharacterized conserved protein [Function unknown]; Region: COG1359
552536000063	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
552536000064	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536000065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000066	active site
552536000067	motif I; other site
552536000068	motif II; other site
552536000069	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
552536000070	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
552536000071	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
552536000072	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
552536000073	putative NAD(P) binding site [chemical binding]; other site
552536000074	dimer interface [polypeptide binding]; other site
552536000075	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
552536000076	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
552536000077	folate binding site [chemical binding]; other site
552536000078	NADP+ binding site [chemical binding]; other site
552536000079	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
552536000080	catalytic triad [active]
552536000081	metal binding site [ion binding]; metal-binding site
552536000082	conserved cis-peptide bond; other site
552536000083	Predicted integral membrane protein [Function unknown]; Region: COG5658
552536000084	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
552536000085	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
552536000086	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
552536000087	peptide binding site [polypeptide binding]; other site
552536000088	conserved hypothetical protein TIGR01655; Region: yxeA_fam
552536000089	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
552536000090	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
552536000091	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536000092	Zn2+ binding site [ion binding]; other site
552536000093	Mg2+ binding site [ion binding]; other site
552536000094	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
552536000095	active site 1 [active]
552536000096	dimer interface [polypeptide binding]; other site
552536000097	hexamer interface [polypeptide binding]; other site
552536000098	active site 2 [active]
552536000099	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
552536000100	Peptidase family M50; Region: Peptidase_M50; pfam02163
552536000101	active site
552536000102	putative substrate binding region [chemical binding]; other site
552536000103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
552536000104	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
552536000105	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
552536000106	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
552536000107	active site
552536000108	HIGH motif; other site
552536000109	KMSK motif region; other site
552536000110	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
552536000111	tRNA binding surface [nucleotide binding]; other site
552536000112	anticodon binding site; other site
552536000113	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
552536000114	CTP synthetase; Validated; Region: pyrG; PRK05380
552536000115	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
552536000116	Catalytic site [active]
552536000117	active site
552536000118	UTP binding site [chemical binding]; other site
552536000119	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
552536000120	active site
552536000121	putative oxyanion hole; other site
552536000122	catalytic triad [active]
552536000123	SH3-like domain; Region: SH3_8; pfam13457
552536000124	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
552536000125	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
552536000126	amidase catalytic site [active]
552536000127	Zn binding residues [ion binding]; other site
552536000128	substrate binding site [chemical binding]; other site
552536000129	SH3-like domain; Region: SH3_8; pfam13457
552536000130	putative lipid kinase; Reviewed; Region: PRK13055
552536000131	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
552536000132	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
552536000133	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
552536000134	intersubunit interface [polypeptide binding]; other site
552536000135	active site
552536000136	zinc binding site [ion binding]; other site
552536000137	Na+ binding site [ion binding]; other site
552536000138	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
552536000139	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
552536000140	putative ADP-binding pocket [chemical binding]; other site
552536000141	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
552536000142	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
552536000143	Predicted integral membrane protein [Function unknown]; Region: COG0392
552536000144	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
552536000145	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
552536000146	hinge; other site
552536000147	active site
552536000148	transcription termination factor Rho; Provisional; Region: rho; PRK09376
552536000149	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
552536000150	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
552536000151	RNA binding site [nucleotide binding]; other site
552536000152	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
552536000153	multimer interface [polypeptide binding]; other site
552536000154	Walker A motif; other site
552536000155	ATP binding site [chemical binding]; other site
552536000156	Walker B motif; other site
552536000157	Predicted membrane protein [Function unknown]; Region: COG2246
552536000158	GtrA-like protein; Region: GtrA; pfam04138
552536000159	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
552536000160	homoserine dehydrogenase; Provisional; Region: PRK06349
552536000161	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
552536000162	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
552536000163	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
552536000164	threonine synthase; Reviewed; Region: PRK06721
552536000165	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
552536000166	homodimer interface [polypeptide binding]; other site
552536000167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536000168	catalytic residue [active]
552536000169	homoserine kinase; Provisional; Region: PRK01212
552536000170	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
552536000171	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
552536000172	thymidine kinase; Provisional; Region: PRK04296
552536000173	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552536000174	ATP binding site [chemical binding]; other site
552536000175	Walker A motif; other site
552536000176	Walker B motif; other site
552536000177	peptide chain release factor 1; Validated; Region: prfA; PRK00591
552536000178	This domain is found in peptide chain release factors; Region: PCRF; smart00937
552536000179	RF-1 domain; Region: RF-1; pfam00472
552536000180	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
552536000181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536000182	S-adenosylmethionine binding site [chemical binding]; other site
552536000183	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
552536000184	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
552536000185	Low molecular weight phosphatase family; Region: LMWPc; cd00115
552536000186	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
552536000187	active site
552536000188	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
552536000189	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
552536000190	dimer interface [polypeptide binding]; other site
552536000191	active site
552536000192	glycine-pyridoxal phosphate binding site [chemical binding]; other site
552536000193	folate binding site [chemical binding]; other site
552536000194	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536000195	active site
552536000196	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
552536000197	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
552536000198	active site
552536000199	homodimer interface [polypeptide binding]; other site
552536000200	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
552536000201	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
552536000202	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
552536000203	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
552536000204	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
552536000205	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
552536000206	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
552536000207	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
552536000208	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
552536000209	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
552536000210	beta subunit interaction interface [polypeptide binding]; other site
552536000211	Walker A motif; other site
552536000212	ATP binding site [chemical binding]; other site
552536000213	Walker B motif; other site
552536000214	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552536000215	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
552536000216	core domain interface [polypeptide binding]; other site
552536000217	delta subunit interface [polypeptide binding]; other site
552536000218	epsilon subunit interface [polypeptide binding]; other site
552536000219	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
552536000220	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
552536000221	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
552536000222	alpha subunit interaction interface [polypeptide binding]; other site
552536000223	Walker A motif; other site
552536000224	ATP binding site [chemical binding]; other site
552536000225	Walker B motif; other site
552536000226	inhibitor binding site; inhibition site
552536000227	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552536000228	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
552536000229	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
552536000230	gamma subunit interface [polypeptide binding]; other site
552536000231	epsilon subunit interface [polypeptide binding]; other site
552536000232	LBP interface [polypeptide binding]; other site
552536000233	Predicted membrane protein [Function unknown]; Region: COG4836
552536000234	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
552536000235	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
552536000236	hinge; other site
552536000237	active site
552536000238	rod shape-determining protein Mbl; Provisional; Region: PRK13928
552536000239	MreB and similar proteins; Region: MreB_like; cd10225
552536000240	nucleotide binding site [chemical binding]; other site
552536000241	Mg binding site [ion binding]; other site
552536000242	putative protofilament interaction site [polypeptide binding]; other site
552536000243	RodZ interaction site [polypeptide binding]; other site
552536000244	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
552536000245	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
552536000246	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
552536000247	dimer interface [polypeptide binding]; other site
552536000248	ssDNA binding site [nucleotide binding]; other site
552536000249	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536000250	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536000251	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
552536000252	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536000253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
552536000254	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
552536000255	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
552536000256	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
552536000257	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
552536000258	active site
552536000259	octamer interface [polypeptide binding]; other site
552536000260	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
552536000261	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
552536000262	Mg++ binding site [ion binding]; other site
552536000263	putative catalytic motif [active]
552536000264	substrate binding site [chemical binding]; other site
552536000265	Transcriptional regulator [Transcription]; Region: LytR; COG1316
552536000266	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552536000267	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552536000268	Uncharacterized conserved protein [Function unknown]; Region: COG1739
552536000269	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
552536000270	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
552536000271	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552536000272	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536000273	active site
552536000274	phosphorylation site [posttranslational modification]
552536000275	intermolecular recognition site; other site
552536000276	dimerization interface [polypeptide binding]; other site
552536000277	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552536000278	DNA binding residues [nucleotide binding]
552536000279	dimerization interface [polypeptide binding]; other site
552536000280	EDD domain protein, DegV family; Region: DegV; TIGR00762
552536000281	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
552536000282	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
552536000283	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536000284	ATP binding site [chemical binding]; other site
552536000285	putative Mg++ binding site [ion binding]; other site
552536000286	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
552536000287	nucleotide binding region [chemical binding]; other site
552536000288	ATP-binding site [chemical binding]; other site
552536000289	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
552536000290	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536000291	active site
552536000292	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
552536000293	30S subunit binding site; other site
552536000294	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
552536000295	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
552536000296	nucleotide binding region [chemical binding]; other site
552536000297	helicase superfamily c-terminal domain; Region: HELICc; smart00490
552536000298	ATP-binding site [chemical binding]; other site
552536000299	SEC-C motif; Region: SEC-C; pfam02810
552536000300	This domain is found in peptide chain release factors; Region: PCRF; smart00937
552536000301	RF-1 domain; Region: RF-1; pfam00472
552536000302	Uncharacterized conserved protein [Function unknown]; Region: COG1284
552536000303	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536000304	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536000305	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536000306	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
552536000307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536000308	Walker A/P-loop; other site
552536000309	ATP binding site [chemical binding]; other site
552536000310	Q-loop/lid; other site
552536000311	ABC transporter signature motif; other site
552536000312	Walker B; other site
552536000313	D-loop; other site
552536000314	H-loop/switch region; other site
552536000315	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
552536000316	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
552536000317	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
552536000318	NlpC/P60 family; Region: NLPC_P60; pfam00877
552536000319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
552536000320	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
552536000321	Peptidase family M23; Region: Peptidase_M23; pfam01551
552536000322	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
552536000323	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
552536000324	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
552536000325	putative active site [active]
552536000326	catalytic site [active]
552536000327	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
552536000328	putative active site [active]
552536000329	catalytic site [active]
552536000330	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
552536000331	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
552536000332	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536000333	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536000334	active site
552536000335	phosphorylation site [posttranslational modification]
552536000336	intermolecular recognition site; other site
552536000337	dimerization interface [polypeptide binding]; other site
552536000338	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536000339	DNA binding site [nucleotide binding]
552536000340	HAMP domain; Region: HAMP; pfam00672
552536000341	dimerization interface [polypeptide binding]; other site
552536000342	PAS domain; Region: PAS; smart00091
552536000343	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
552536000344	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536000345	dimer interface [polypeptide binding]; other site
552536000346	phosphorylation site [posttranslational modification]
552536000347	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536000348	ATP binding site [chemical binding]; other site
552536000349	Mg2+ binding site [ion binding]; other site
552536000350	G-X-G motif; other site
552536000351	PBP superfamily domain; Region: PBP_like_2; cl17296
552536000352	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
552536000353	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
552536000354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000355	dimer interface [polypeptide binding]; other site
552536000356	conserved gate region; other site
552536000357	putative PBP binding loops; other site
552536000358	ABC-ATPase subunit interface; other site
552536000359	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
552536000360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000361	dimer interface [polypeptide binding]; other site
552536000362	conserved gate region; other site
552536000363	putative PBP binding loops; other site
552536000364	ABC-ATPase subunit interface; other site
552536000365	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
552536000366	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
552536000367	Walker A/P-loop; other site
552536000368	ATP binding site [chemical binding]; other site
552536000369	Q-loop/lid; other site
552536000370	ABC transporter signature motif; other site
552536000371	Walker B; other site
552536000372	D-loop; other site
552536000373	H-loop/switch region; other site
552536000374	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
552536000375	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
552536000376	Walker A/P-loop; other site
552536000377	ATP binding site [chemical binding]; other site
552536000378	Q-loop/lid; other site
552536000379	ABC transporter signature motif; other site
552536000380	Walker B; other site
552536000381	D-loop; other site
552536000382	H-loop/switch region; other site
552536000383	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
552536000384	PhoU domain; Region: PhoU; pfam01895
552536000385	PhoU domain; Region: PhoU; pfam01895
552536000386	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536000387	dimerization interface [polypeptide binding]; other site
552536000388	putative DNA binding site [nucleotide binding]; other site
552536000389	putative Zn2+ binding site [ion binding]; other site
552536000390	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536000391	Zn2+ binding site [ion binding]; other site
552536000392	Mg2+ binding site [ion binding]; other site
552536000393	Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559
552536000394	excinuclease ABC subunit B; Provisional; Region: PRK05298
552536000395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536000396	ATP binding site [chemical binding]; other site
552536000397	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536000398	nucleotide binding region [chemical binding]; other site
552536000399	ATP-binding site [chemical binding]; other site
552536000400	Ultra-violet resistance protein B; Region: UvrB; pfam12344
552536000401	UvrB/uvrC motif; Region: UVR; pfam02151
552536000402	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
552536000403	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552536000404	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552536000405	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
552536000406	Uncharacterized conserved protein [Function unknown]; Region: COG3595
552536000407	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
552536000408	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
552536000409	Uncharacterized conserved protein [Function unknown]; Region: COG3595
552536000410	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
552536000411	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
552536000412	Predicted membrane protein [Function unknown]; Region: COG1950
552536000413	HPr kinase/phosphorylase; Provisional; Region: PRK05428
552536000414	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
552536000415	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
552536000416	Hpr binding site; other site
552536000417	active site
552536000418	homohexamer subunit interaction site [polypeptide binding]; other site
552536000419	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
552536000420	pyrophosphatase PpaX; Provisional; Region: PRK13288
552536000421	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536000422	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000423	motif II; other site
552536000424	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
552536000425	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
552536000426	putative trimer interface [polypeptide binding]; other site
552536000427	putative CoA binding site [chemical binding]; other site
552536000428	TPR repeat; Region: TPR_11; pfam13414
552536000429	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536000430	binding surface
552536000431	TPR motif; other site
552536000432	Tetratricopeptide repeat; Region: TPR_12; pfam13424
552536000433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536000434	binding surface
552536000435	TPR motif; other site
552536000436	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
552536000437	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536000438	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536000439	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
552536000440	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
552536000441	NAD binding site [chemical binding]; other site
552536000442	homodimer interface [polypeptide binding]; other site
552536000443	active site
552536000444	substrate binding site [chemical binding]; other site
552536000445	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
552536000446	active site
552536000447	catalytic residues [active]
552536000448	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
552536000449	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
552536000450	active site
552536000451	substrate binding site [chemical binding]; other site
552536000452	metal binding site [ion binding]; metal-binding site
552536000453	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
552536000454	AAA domain; Region: AAA_18; pfam13238
552536000455	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
552536000456	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
552536000457	phosphate binding site [ion binding]; other site
552536000458	putative substrate binding pocket [chemical binding]; other site
552536000459	dimer interface [polypeptide binding]; other site
552536000460	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
552536000461	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
552536000462	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
552536000463	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
552536000464	active site
552536000465	FMN binding site [chemical binding]; other site
552536000466	substrate binding site [chemical binding]; other site
552536000467	homotetramer interface [polypeptide binding]; other site
552536000468	catalytic residue [active]
552536000469	amino acid transporter; Region: 2A0306; TIGR00909
552536000470	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
552536000471	Clp protease; Region: CLP_protease; pfam00574
552536000472	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
552536000473	oligomer interface [polypeptide binding]; other site
552536000474	active site residues [active]
552536000475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
552536000476	Chitin binding domain; Region: Chitin_bind_3; pfam03067
552536000477	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
552536000478	Interdomain contacts; other site
552536000479	Cytokine receptor motif; other site
552536000480	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
552536000481	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
552536000482	Interdomain contacts; other site
552536000483	Cytokine receptor motif; other site
552536000484	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
552536000485	aromatic chitin/cellulose binding site residues [chemical binding]; other site
552536000486	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
552536000487	aromatic chitin/cellulose binding site residues [chemical binding]; other site
552536000488	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
552536000489	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536000490	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536000491	MMPL family; Region: MMPL; pfam03176
552536000492	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
552536000493	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
552536000494	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
552536000495	active site
552536000496	dimer interface [polypeptide binding]; other site
552536000497	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
552536000498	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
552536000499	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
552536000500	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536000501	DNA binding site [nucleotide binding]
552536000502	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
552536000503	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
552536000504	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
552536000505	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
552536000506	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
552536000507	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
552536000508	Phosphoglycerate kinase; Region: PGK; pfam00162
552536000509	substrate binding site [chemical binding]; other site
552536000510	hinge regions; other site
552536000511	ADP binding site [chemical binding]; other site
552536000512	catalytic site [active]
552536000513	triosephosphate isomerase; Provisional; Region: PRK14567
552536000514	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
552536000515	substrate binding site [chemical binding]; other site
552536000516	dimer interface [polypeptide binding]; other site
552536000517	catalytic triad [active]
552536000518	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
552536000519	phosphoglyceromutase; Provisional; Region: PRK05434
552536000520	enolase; Provisional; Region: eno; PRK00077
552536000521	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
552536000522	dimer interface [polypeptide binding]; other site
552536000523	metal binding site [ion binding]; metal-binding site
552536000524	substrate binding pocket [chemical binding]; other site
552536000525	PGAP1-like protein; Region: PGAP1; pfam07819
552536000526	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552536000527	Esterase/lipase [General function prediction only]; Region: COG1647
552536000528	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552536000529	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
552536000530	Preprotein translocase SecG subunit; Region: SecG; cl09123
552536000531	Esterase/lipase [General function prediction only]; Region: COG1647
552536000532	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552536000533	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552536000534	ribonuclease R; Region: RNase_R; TIGR02063
552536000535	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
552536000536	RNB domain; Region: RNB; pfam00773
552536000537	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
552536000538	RNA binding site [nucleotide binding]; other site
552536000539	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
552536000540	SmpB-tmRNA interface; other site
552536000541	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536000542	non-specific DNA binding site [nucleotide binding]; other site
552536000543	salt bridge; other site
552536000544	sequence-specific DNA binding site [nucleotide binding]; other site
552536000545	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
552536000546	Tetratricopeptide repeat; Region: TPR_12; pfam13424
552536000547	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
552536000548	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
552536000549	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
552536000550	active site
552536000551	catalytic site [active]
552536000552	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
552536000553	putative metal binding site [ion binding]; other site
552536000554	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536000555	Leucine rich repeat; Region: LRR_8; pfam13855
552536000556	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
552536000557	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
552536000558	active site
552536000559	catalytic site [active]
552536000560	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
552536000561	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
552536000562	putative metal binding site [ion binding]; other site
552536000563	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536000564	Leucine rich repeat; Region: LRR_8; pfam13855
552536000565	Uncharacterized conserved protein [Function unknown]; Region: COG1434
552536000566	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
552536000567	putative active site [active]
552536000568	Predicted transcriptional regulator [Transcription]; Region: COG2378
552536000569	HTH domain; Region: HTH_11; pfam08279
552536000570	WYL domain; Region: WYL; pfam13280
552536000571	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
552536000572	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5294
552536000573	Uncharacterized conserved protein [Function unknown]; Region: COG4283
552536000574	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
552536000575	transcriptional antiterminator BglG; Provisional; Region: PRK09772
552536000576	CAT RNA binding domain; Region: CAT_RBD; smart01061
552536000577	PRD domain; Region: PRD; pfam00874
552536000578	PRD domain; Region: PRD; pfam00874
552536000579	SdpI/YhfL protein family; Region: SdpI; pfam13630
552536000580	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
552536000581	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536000582	catalytic residue [active]
552536000583	Predicted esterase [General function prediction only]; Region: COG0627
552536000584	S-formylglutathione hydrolase; Region: PLN02442
552536000585	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
552536000586	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
552536000587	intersubunit interface [polypeptide binding]; other site
552536000588	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
552536000589	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536000590	ABC-ATPase subunit  interface; other site
552536000591	dimer interface [polypeptide binding]; other site
552536000592	putative PBP binding regions; other site
552536000593	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
552536000594	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
552536000595	Walker A/P-loop; other site
552536000596	ATP binding site [chemical binding]; other site
552536000597	Q-loop/lid; other site
552536000598	ABC transporter signature motif; other site
552536000599	Walker B; other site
552536000600	D-loop; other site
552536000601	H-loop/switch region; other site
552536000602	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
552536000603	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
552536000604	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
552536000605	ArsC family; Region: ArsC; pfam03960
552536000606	putative ArsC-like catalytic residues; other site
552536000607	putative TRX-like catalytic residues [active]
552536000608	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
552536000609	lipoyl attachment site [posttranslational modification]; other site
552536000610	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536000611	catalytic residues [active]
552536000612	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
552536000613	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
552536000614	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536000615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536000616	active site
552536000617	phosphorylation site [posttranslational modification]
552536000618	intermolecular recognition site; other site
552536000619	dimerization interface [polypeptide binding]; other site
552536000620	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536000621	DNA binding site [nucleotide binding]
552536000622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536000623	dimer interface [polypeptide binding]; other site
552536000624	phosphorylation site [posttranslational modification]
552536000625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536000626	ATP binding site [chemical binding]; other site
552536000627	Mg2+ binding site [ion binding]; other site
552536000628	G-X-G motif; other site
552536000629	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
552536000630	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
552536000631	Walker A/P-loop; other site
552536000632	ATP binding site [chemical binding]; other site
552536000633	Q-loop/lid; other site
552536000634	ABC transporter signature motif; other site
552536000635	Walker B; other site
552536000636	D-loop; other site
552536000637	H-loop/switch region; other site
552536000638	NIL domain; Region: NIL; pfam09383
552536000639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000640	ABC-ATPase subunit interface; other site
552536000641	putative PBP binding loops; other site
552536000642	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
552536000643	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
552536000644	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
552536000645	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
552536000646	Walker A/P-loop; other site
552536000647	ATP binding site [chemical binding]; other site
552536000648	Q-loop/lid; other site
552536000649	ABC transporter signature motif; other site
552536000650	Walker B; other site
552536000651	D-loop; other site
552536000652	H-loop/switch region; other site
552536000653	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
552536000654	FeS assembly protein SufD; Region: sufD; TIGR01981
552536000655	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
552536000656	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
552536000657	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536000658	catalytic residue [active]
552536000659	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
552536000660	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
552536000661	trimerization site [polypeptide binding]; other site
552536000662	active site
552536000663	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
552536000664	FeS assembly protein SufB; Region: sufB; TIGR01980
552536000665	Uncharacterized conserved protein [Function unknown]; Region: COG1801
552536000666	Predicted membrane protein [Function unknown]; Region: COG4272
552536000667	Predicted permeases [General function prediction only]; Region: COG0730
552536000668	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
552536000669	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
552536000670	active site
552536000671	metal binding site [ion binding]; metal-binding site
552536000672	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
552536000673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
552536000674	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
552536000675	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000676	active site
552536000677	motif I; other site
552536000678	motif II; other site
552536000679	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000680	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552536000681	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536000682	Coenzyme A binding pocket [chemical binding]; other site
552536000683	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
552536000684	Domain of unknown function DUF21; Region: DUF21; pfam01595
552536000685	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
552536000686	Transporter associated domain; Region: CorC_HlyC; smart01091
552536000687	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
552536000688	tetramer interfaces [polypeptide binding]; other site
552536000689	binuclear metal-binding site [ion binding]; other site
552536000690	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
552536000691	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536000692	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536000693	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000694	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000695	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000696	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000697	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000698	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536000699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
552536000700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
552536000701	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
552536000702	NADH(P)-binding; Region: NAD_binding_10; pfam13460
552536000703	NAD(P) binding site [chemical binding]; other site
552536000704	putative active site [active]
552536000705	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
552536000706	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536000707	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536000708	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
552536000709	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536000710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
552536000711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
552536000712	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
552536000713	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
552536000714	Cl- selectivity filter; other site
552536000715	Cl- binding residues [ion binding]; other site
552536000716	pore gating glutamate residue; other site
552536000717	dimer interface [polypeptide binding]; other site
552536000718	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
552536000719	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
552536000720	CoenzymeA binding site [chemical binding]; other site
552536000721	subunit interaction site [polypeptide binding]; other site
552536000722	PHB binding site; other site
552536000723	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
552536000724	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
552536000725	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
552536000726	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
552536000727	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
552536000728	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
552536000729	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
552536000730	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
552536000731	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
552536000732	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
552536000733	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536000734	drug efflux system protein MdtG; Provisional; Region: PRK09874
552536000735	putative substrate translocation pore; other site
552536000736	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
552536000737	active site
552536000738	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
552536000739	putative active site [active]
552536000740	putative NTP binding site [chemical binding]; other site
552536000741	putative nucleic acid binding site [nucleotide binding]; other site
552536000742	aspartate kinase; Reviewed; Region: PRK09034
552536000743	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
552536000744	putative catalytic residues [active]
552536000745	putative nucleotide binding site [chemical binding]; other site
552536000746	putative aspartate binding site [chemical binding]; other site
552536000747	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
552536000748	allosteric regulatory residue; other site
552536000749	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
552536000750	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536000751	active site
552536000752	P-loop; other site
552536000753	phosphorylation site [posttranslational modification]
552536000754	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536000755	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536000756	Walker A/P-loop; other site
552536000757	ATP binding site [chemical binding]; other site
552536000758	Q-loop/lid; other site
552536000759	ABC transporter signature motif; other site
552536000760	Walker B; other site
552536000761	D-loop; other site
552536000762	H-loop/switch region; other site
552536000763	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
552536000764	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
552536000765	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536000766	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536000767	homodimer interface [polypeptide binding]; other site
552536000768	catalytic residue [active]
552536000769	general stress protein 13; Validated; Region: PRK08059
552536000770	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
552536000771	RNA binding site [nucleotide binding]; other site
552536000772	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
552536000773	nudix motif; other site
552536000774	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
552536000775	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
552536000776	active site
552536000777	dimer interface [polypeptide binding]; other site
552536000778	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
552536000779	dimer interface [polypeptide binding]; other site
552536000780	active site
552536000781	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536000782	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
552536000783	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536000784	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
552536000785	active site
552536000786	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
552536000787	ADP-ribose binding site [chemical binding]; other site
552536000788	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
552536000789	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536000790	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
552536000791	L-tyrosine decarboxylase; Provisional; Region: PRK13520
552536000792	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
552536000793	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536000794	catalytic residue [active]
552536000795	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
552536000796	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
552536000797	ADP-ribose binding site [chemical binding]; other site
552536000798	Predicted transcriptional regulator [Transcription]; Region: COG1959
552536000799	Transcriptional regulator; Region: Rrf2; pfam02082
552536000800	Predicted membrane protein [Function unknown]; Region: COG1511
552536000801	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
552536000802	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
552536000803	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
552536000804	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536000805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
552536000806	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
552536000807	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
552536000808	active site
552536000809	trimer interface [polypeptide binding]; other site
552536000810	allosteric site; other site
552536000811	active site lid [active]
552536000812	hexamer (dimer of trimers) interface [polypeptide binding]; other site
552536000813	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
552536000814	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536000815	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536000816	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536000817	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
552536000818	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
552536000819	active site
552536000820	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
552536000821	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536000822	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536000823	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552536000824	dimerization interface [polypeptide binding]; other site
552536000825	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
552536000826	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552536000827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536000828	Coenzyme A binding pocket [chemical binding]; other site
552536000829	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552536000830	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552536000831	substrate binding pocket [chemical binding]; other site
552536000832	membrane-bound complex binding site; other site
552536000833	hinge residues; other site
552536000834	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552536000835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000836	dimer interface [polypeptide binding]; other site
552536000837	conserved gate region; other site
552536000838	putative PBP binding loops; other site
552536000839	ABC-ATPase subunit interface; other site
552536000840	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552536000841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000842	dimer interface [polypeptide binding]; other site
552536000843	conserved gate region; other site
552536000844	putative PBP binding loops; other site
552536000845	ABC-ATPase subunit interface; other site
552536000846	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552536000847	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
552536000848	Walker A/P-loop; other site
552536000849	ATP binding site [chemical binding]; other site
552536000850	Q-loop/lid; other site
552536000851	ABC transporter signature motif; other site
552536000852	Walker B; other site
552536000853	D-loop; other site
552536000854	H-loop/switch region; other site
552536000855	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
552536000856	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
552536000857	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
552536000858	catalytic residues [active]
552536000859	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
552536000860	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
552536000861	active site
552536000862	non-prolyl cis peptide bond; other site
552536000863	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
552536000864	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536000865	RNA binding surface [nucleotide binding]; other site
552536000866	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
552536000867	active site
552536000868	uracil binding [chemical binding]; other site
552536000869	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
552536000870	non-specific DNA interactions [nucleotide binding]; other site
552536000871	DNA binding site [nucleotide binding]
552536000872	sequence specific DNA binding site [nucleotide binding]; other site
552536000873	putative cAMP binding site [chemical binding]; other site
552536000874	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
552536000875	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
552536000876	substrate binding site [chemical binding]; other site
552536000877	ATP binding site [chemical binding]; other site
552536000878	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
552536000879	Uncharacterized conserved protein [Function unknown]; Region: COG1683
552536000880	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
552536000881	trimer interface [polypeptide binding]; other site
552536000882	active site
552536000883	G bulge; other site
552536000884	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536000885	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
552536000886	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536000887	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
552536000888	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
552536000889	putative substrate binding site [chemical binding]; other site
552536000890	putative ATP binding site [chemical binding]; other site
552536000891	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
552536000892	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536000893	active site
552536000894	phosphorylation site [posttranslational modification]
552536000895	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536000896	active site
552536000897	P-loop; other site
552536000898	phosphorylation site [posttranslational modification]
552536000899	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536000900	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536000901	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536000902	non-specific DNA binding site [nucleotide binding]; other site
552536000903	salt bridge; other site
552536000904	sequence-specific DNA binding site [nucleotide binding]; other site
552536000905	ComK protein; Region: ComK; cl11560
552536000906	IDEAL domain; Region: IDEAL; pfam08858
552536000907	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
552536000908	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
552536000909	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
552536000910	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536000911	Family description; Region: UvrD_C_2; pfam13538
552536000912	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
552536000913	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
552536000914	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
552536000915	hypothetical protein; Provisional; Region: PRK13673
552536000916	Uncharacterized conserved protein [Function unknown]; Region: COG1284
552536000917	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536000918	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536000919	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536000920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
552536000921	motif II; other site
552536000922	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000923	esterase; Provisional; Region: PRK10566
552536000924	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552536000925	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
552536000926	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536000927	Coenzyme A binding pocket [chemical binding]; other site
552536000928	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536000929	methionine cluster; other site
552536000930	active site
552536000931	phosphorylation site [posttranslational modification]
552536000932	metal binding site [ion binding]; metal-binding site
552536000933	intracellular protease, PfpI family; Region: PfpI; TIGR01382
552536000934	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
552536000935	proposed catalytic triad [active]
552536000936	conserved cys residue [active]
552536000937	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
552536000938	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
552536000939	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536000940	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536000941	motif II; other site
552536000942	aspartate aminotransferase; Provisional; Region: PRK06348
552536000943	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536000944	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536000945	homodimer interface [polypeptide binding]; other site
552536000946	catalytic residue [active]
552536000947	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552536000948	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
552536000949	Walker A/P-loop; other site
552536000950	ATP binding site [chemical binding]; other site
552536000951	Q-loop/lid; other site
552536000952	ABC transporter signature motif; other site
552536000953	Walker B; other site
552536000954	D-loop; other site
552536000955	H-loop/switch region; other site
552536000956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552536000957	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552536000958	substrate binding pocket [chemical binding]; other site
552536000959	membrane-bound complex binding site; other site
552536000960	hinge residues; other site
552536000961	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552536000962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536000963	dimer interface [polypeptide binding]; other site
552536000964	conserved gate region; other site
552536000965	putative PBP binding loops; other site
552536000966	ABC-ATPase subunit interface; other site
552536000967	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
552536000968	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
552536000969	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536000970	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536000971	active site
552536000972	catalytic tetrad [active]
552536000973	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
552536000974	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
552536000975	active site
552536000976	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
552536000977	putative dimer interface [polypeptide binding]; other site
552536000978	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536000979	ligand binding site [chemical binding]; other site
552536000980	Zn binding site [ion binding]; other site
552536000981	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
552536000982	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
552536000983	active site
552536000984	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
552536000985	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
552536000986	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536000987	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536000988	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
552536000989	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
552536000990	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
552536000991	DNA binding site [nucleotide binding]
552536000992	active site
552536000993	Predicted transcriptional regulators [Transcription]; Region: COG1725
552536000994	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536000995	DNA-binding site [nucleotide binding]; DNA binding site
552536000996	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536000997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536000998	Walker A/P-loop; other site
552536000999	ATP binding site [chemical binding]; other site
552536001000	Q-loop/lid; other site
552536001001	ABC transporter signature motif; other site
552536001002	Walker B; other site
552536001003	D-loop; other site
552536001004	H-loop/switch region; other site
552536001005	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536001006	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536001007	putative substrate translocation pore; other site
552536001008	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536001009	putative substrate translocation pore; other site
552536001010	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536001011	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
552536001012	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
552536001013	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
552536001014	shikimate binding site; other site
552536001015	NAD(P) binding site [chemical binding]; other site
552536001016	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
552536001017	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
552536001018	active site
552536001019	FMN binding site [chemical binding]; other site
552536001020	substrate binding site [chemical binding]; other site
552536001021	putative catalytic residue [active]
552536001022	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536001023	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536001024	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
552536001025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536001026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536001027	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
552536001028	putative dimerization interface [polypeptide binding]; other site
552536001029	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
552536001030	Domain of unknown function DUF21; Region: DUF21; pfam01595
552536001031	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
552536001032	Transporter associated domain; Region: CorC_HlyC; smart01091
552536001033	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
552536001034	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
552536001035	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
552536001036	Low molecular weight phosphatase family; Region: LMWPc; cl00105
552536001037	Transglycosylase; Region: Transgly; pfam00912
552536001038	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
552536001039	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552536001040	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
552536001041	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536001042	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552536001043	Walker A/P-loop; other site
552536001044	ATP binding site [chemical binding]; other site
552536001045	Q-loop/lid; other site
552536001046	ABC transporter signature motif; other site
552536001047	Walker B; other site
552536001048	D-loop; other site
552536001049	H-loop/switch region; other site
552536001050	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
552536001051	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552536001052	fumarate hydratase; Reviewed; Region: fumC; PRK00485
552536001053	Class II fumarases; Region: Fumarase_classII; cd01362
552536001054	active site
552536001055	tetramer interface [polypeptide binding]; other site
552536001056	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
552536001057	hypothetical protein; Provisional; Region: PRK13676
552536001058	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
552536001059	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
552536001060	active site
552536001061	metal binding site [ion binding]; metal-binding site
552536001062	DNA binding site [nucleotide binding]
552536001063	Uncharacterized conserved protein [Function unknown]; Region: COG4717
552536001064	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
552536001065	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
552536001066	generic binding surface II; other site
552536001067	generic binding surface I; other site
552536001068	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536001069	Zn2+ binding site [ion binding]; other site
552536001070	Mg2+ binding site [ion binding]; other site
552536001071	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
552536001072	SurA N-terminal domain; Region: SurA_N_3; cl07813
552536001073	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
552536001074	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
552536001075	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
552536001076	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
552536001077	HIT family signature motif; other site
552536001078	catalytic residue [active]
552536001079	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
552536001080	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552536001081	Walker A/P-loop; other site
552536001082	ATP binding site [chemical binding]; other site
552536001083	Q-loop/lid; other site
552536001084	ABC transporter signature motif; other site
552536001085	Walker B; other site
552536001086	D-loop; other site
552536001087	H-loop/switch region; other site
552536001088	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
552536001089	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
552536001090	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
552536001091	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
552536001092	substrate binding site [chemical binding]; other site
552536001093	active site
552536001094	ferrochelatase; Provisional; Region: PRK12435
552536001095	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
552536001096	C-terminal domain interface [polypeptide binding]; other site
552536001097	active site
552536001098	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
552536001099	active site
552536001100	N-terminal domain interface [polypeptide binding]; other site
552536001101	Predicted acetyltransferase [General function prediction only]; Region: COG3393
552536001102	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
552536001103	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536001104	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536001105	active site
552536001106	motif I; other site
552536001107	motif II; other site
552536001108	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536001109	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
552536001110	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
552536001111	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
552536001112	Clp amino terminal domain; Region: Clp_N; pfam02861
552536001113	Clp amino terminal domain; Region: Clp_N; pfam02861
552536001114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536001115	Walker A motif; other site
552536001116	ATP binding site [chemical binding]; other site
552536001117	Walker B motif; other site
552536001118	arginine finger; other site
552536001119	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536001120	Walker A motif; other site
552536001121	ATP binding site [chemical binding]; other site
552536001122	Walker B motif; other site
552536001123	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
552536001124	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536001125	catalytic core [active]
552536001126	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536001127	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
552536001128	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536001129	SH3-like domain; Region: SH3_8; pfam13457
552536001130	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
552536001131	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
552536001132	dimer interface [polypeptide binding]; other site
552536001133	active site
552536001134	CoA binding pocket [chemical binding]; other site
552536001135	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
552536001136	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
552536001137	dimer interface [polypeptide binding]; other site
552536001138	active site
552536001139	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536001140	MarR family; Region: MarR; pfam01047
552536001141	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
552536001142	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
552536001143	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
552536001144	active site
552536001145	HIGH motif; other site
552536001146	dimer interface [polypeptide binding]; other site
552536001147	KMSKS motif; other site
552536001148	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
552536001149	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
552536001150	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
552536001151	peptide binding site [polypeptide binding]; other site
552536001152	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
552536001153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001154	dimer interface [polypeptide binding]; other site
552536001155	conserved gate region; other site
552536001156	putative PBP binding loops; other site
552536001157	ABC-ATPase subunit interface; other site
552536001158	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
552536001159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001160	dimer interface [polypeptide binding]; other site
552536001161	conserved gate region; other site
552536001162	putative PBP binding loops; other site
552536001163	ABC-ATPase subunit interface; other site
552536001164	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
552536001165	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552536001166	Walker A/P-loop; other site
552536001167	ATP binding site [chemical binding]; other site
552536001168	Q-loop/lid; other site
552536001169	ABC transporter signature motif; other site
552536001170	Walker B; other site
552536001171	D-loop; other site
552536001172	H-loop/switch region; other site
552536001173	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552536001174	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
552536001175	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552536001176	Walker A/P-loop; other site
552536001177	ATP binding site [chemical binding]; other site
552536001178	Q-loop/lid; other site
552536001179	ABC transporter signature motif; other site
552536001180	Walker B; other site
552536001181	D-loop; other site
552536001182	H-loop/switch region; other site
552536001183	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552536001184	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
552536001185	ArsC family; Region: ArsC; pfam03960
552536001186	putative catalytic residues [active]
552536001187	thiol/disulfide switch; other site
552536001188	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
552536001189	Competence protein CoiA-like family; Region: CoiA; cl11541
552536001190	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
552536001191	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
552536001192	active site
552536001193	Zn binding site [ion binding]; other site
552536001194	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
552536001195	heme uptake protein IsdC; Region: IsdC; TIGR03656
552536001196	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
552536001197	heme-binding site [chemical binding]; other site
552536001198	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
552536001199	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
552536001200	heme-binding site [chemical binding]; other site
552536001201	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
552536001202	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
552536001203	heme-binding site [chemical binding]; other site
552536001204	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
552536001205	heme-binding site [chemical binding]; other site
552536001206	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
552536001207	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
552536001208	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
552536001209	intersubunit interface [polypeptide binding]; other site
552536001210	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
552536001211	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536001212	ABC-ATPase subunit  interface; other site
552536001213	dimer interface [polypeptide binding]; other site
552536001214	putative PBP binding regions; other site
552536001215	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
552536001216	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
552536001217	Walker A/P-loop; other site
552536001218	ATP binding site [chemical binding]; other site
552536001219	Q-loop/lid; other site
552536001220	ABC transporter signature motif; other site
552536001221	Walker B; other site
552536001222	D-loop; other site
552536001223	H-loop/switch region; other site
552536001224	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
552536001225	active site
552536001226	catalytic site [active]
552536001227	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
552536001228	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536001229	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536001230	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536001231	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
552536001232	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001233	Collagen binding domain; Region: Collagen_bind; pfam05737
552536001234	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001235	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001236	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001237	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001238	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001239	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536001240	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
552536001241	Collagen binding domain; Region: Collagen_bind; pfam05737
552536001242	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001243	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001244	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001245	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001246	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001247	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001248	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536001249	Tic20-like protein; Region: Tic20; pfam09685
552536001250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536001251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536001252	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
552536001253	classical (c) SDRs; Region: SDR_c; cd05233
552536001254	NAD(P) binding site [chemical binding]; other site
552536001255	active site
552536001256	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
552536001257	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
552536001258	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
552536001259	metal binding site [ion binding]; metal-binding site
552536001260	active site
552536001261	I-site; other site
552536001262	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
552536001263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536001264	Walker A motif; other site
552536001265	ATP binding site [chemical binding]; other site
552536001266	Walker B motif; other site
552536001267	arginine finger; other site
552536001268	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
552536001269	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
552536001270	Coenzyme A transferase; Region: CoA_trans; smart00882
552536001271	Coenzyme A transferase; Region: CoA_trans; cl17247
552536001272	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
552536001273	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
552536001274	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
552536001275	FMN binding site [chemical binding]; other site
552536001276	substrate binding site [chemical binding]; other site
552536001277	putative catalytic residue [active]
552536001278	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536001279	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
552536001280	dimer interface [polypeptide binding]; other site
552536001281	active site
552536001282	metal binding site [ion binding]; metal-binding site
552536001283	glutathione binding site [chemical binding]; other site
552536001284	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536001285	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536001286	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536001287	ligand binding site [chemical binding]; other site
552536001288	flexible hinge region; other site
552536001289	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
552536001290	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536001291	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
552536001292	Cupin domain; Region: Cupin_2; pfam07883
552536001293	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536001294	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536001295	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536001296	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536001297	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
552536001298	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
552536001299	conserved cys residue [active]
552536001300	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
552536001301	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
552536001302	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536001303	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536001304	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
552536001305	CsbD-like; Region: CsbD; cl17424
552536001306	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
552536001307	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
552536001308	Class I ribonucleotide reductase; Region: RNR_I; cd01679
552536001309	active site
552536001310	dimer interface [polypeptide binding]; other site
552536001311	catalytic residues [active]
552536001312	effector binding site; other site
552536001313	R2 peptide binding site; other site
552536001314	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
552536001315	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
552536001316	dimer interface [polypeptide binding]; other site
552536001317	putative radical transfer pathway; other site
552536001318	diiron center [ion binding]; other site
552536001319	tyrosyl radical; other site
552536001320	flavodoxin; Provisional; Region: PRK09271
552536001321	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536001322	catalytic residues [active]
552536001323	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
552536001324	homodimer interface [polypeptide binding]; other site
552536001325	chemical substrate binding site [chemical binding]; other site
552536001326	oligomer interface [polypeptide binding]; other site
552536001327	metal binding site [ion binding]; metal-binding site
552536001328	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
552536001329	putative metal binding site [ion binding]; other site
552536001330	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
552536001331	Predicted membrane protein [Function unknown]; Region: COG2855
552536001332	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536001333	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536001334	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
552536001335	putative dimerization interface [polypeptide binding]; other site
552536001336	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
552536001337	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
552536001338	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536001339	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536001340	DNA-binding site [nucleotide binding]; DNA binding site
552536001341	UTRA domain; Region: UTRA; pfam07702
552536001342	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
552536001343	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
552536001344	Transcriptional regulators [Transcription]; Region: GntR; COG1802
552536001345	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
552536001346	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536001347	Coenzyme A binding pocket [chemical binding]; other site
552536001348	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
552536001349	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
552536001350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536001351	Walker A/P-loop; other site
552536001352	ATP binding site [chemical binding]; other site
552536001353	Q-loop/lid; other site
552536001354	ABC transporter signature motif; other site
552536001355	Walker B; other site
552536001356	D-loop; other site
552536001357	H-loop/switch region; other site
552536001358	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
552536001359	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536001360	HTH domain; Region: HTH_11; pfam08279
552536001361	PRD domain; Region: PRD; pfam00874
552536001362	PRD domain; Region: PRD; pfam00874
552536001363	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536001364	active site
552536001365	P-loop; other site
552536001366	phosphorylation site [posttranslational modification]
552536001367	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536001368	active site
552536001369	phosphorylation site [posttranslational modification]
552536001370	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536001371	active site
552536001372	P-loop; other site
552536001373	phosphorylation site [posttranslational modification]
552536001374	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536001375	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
552536001376	intersubunit interface [polypeptide binding]; other site
552536001377	active site
552536001378	zinc binding site [ion binding]; other site
552536001379	Na+ binding site [ion binding]; other site
552536001380	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
552536001381	intersubunit interface [polypeptide binding]; other site
552536001382	active site
552536001383	zinc binding site [ion binding]; other site
552536001384	Na+ binding site [ion binding]; other site
552536001385	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
552536001386	ligand binding site [chemical binding]; other site
552536001387	flexible hinge region; other site
552536001388	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536001389	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536001390	ligand binding site [chemical binding]; other site
552536001391	Amino acid permease; Region: AA_permease_2; pfam13520
552536001392	K+ potassium transporter; Region: K_trans; cl15781
552536001393	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536001394	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536001395	DNA binding site [nucleotide binding]
552536001396	domain linker motif; other site
552536001397	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552536001398	ligand binding site [chemical binding]; other site
552536001399	dimerization interface [polypeptide binding]; other site
552536001400	CAAX protease self-immunity; Region: Abi; cl00558
552536001401	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
552536001402	homodimer interface [polypeptide binding]; other site
552536001403	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552536001404	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
552536001405	active site
552536001406	homodimer interface [polypeptide binding]; other site
552536001407	catalytic site [active]
552536001408	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
552536001409	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536001410	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001411	dimer interface [polypeptide binding]; other site
552536001412	conserved gate region; other site
552536001413	putative PBP binding loops; other site
552536001414	ABC-ATPase subunit interface; other site
552536001415	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536001416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001417	dimer interface [polypeptide binding]; other site
552536001418	conserved gate region; other site
552536001419	putative PBP binding loops; other site
552536001420	ABC-ATPase subunit interface; other site
552536001421	Predicted integral membrane protein [Function unknown]; Region: COG5521
552536001422	maltose phosphorylase; Provisional; Region: PRK13807
552536001423	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
552536001424	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
552536001425	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
552536001426	Uncharacterized conserved protein [Function unknown]; Region: COG1624
552536001427	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
552536001428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
552536001429	YbbR-like protein; Region: YbbR; pfam07949
552536001430	YbbR-like protein; Region: YbbR; pfam07949
552536001431	YbbR-like protein; Region: YbbR; pfam07949
552536001432	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
552536001433	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
552536001434	active site
552536001435	substrate binding site [chemical binding]; other site
552536001436	metal binding site [ion binding]; metal-binding site
552536001437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536001438	Coenzyme A binding pocket [chemical binding]; other site
552536001439	FtsX-like permease family; Region: FtsX; pfam02687
552536001440	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536001441	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536001442	Walker A/P-loop; other site
552536001443	ATP binding site [chemical binding]; other site
552536001444	Q-loop/lid; other site
552536001445	ABC transporter signature motif; other site
552536001446	Walker B; other site
552536001447	D-loop; other site
552536001448	H-loop/switch region; other site
552536001449	putative heme peroxidase; Provisional; Region: PRK12276
552536001450	Helix-turn-helix domain; Region: HTH_17; pfam12728
552536001451	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
552536001452	dimer interface [polypeptide binding]; other site
552536001453	FMN binding site [chemical binding]; other site
552536001454	NADPH bind site [chemical binding]; other site
552536001455	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
552536001456	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
552536001457	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
552536001458	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
552536001459	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
552536001460	active site
552536001461	dimer interface [polypeptide binding]; other site
552536001462	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536001463	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
552536001464	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536001465	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
552536001466	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
552536001467	putative active site [active]
552536001468	putative metal binding site [ion binding]; other site
552536001469	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
552536001470	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
552536001471	G1 box; other site
552536001472	GTP/Mg2+ binding site [chemical binding]; other site
552536001473	Switch I region; other site
552536001474	G2 box; other site
552536001475	G3 box; other site
552536001476	Switch II region; other site
552536001477	G4 box; other site
552536001478	G5 box; other site
552536001479	Nucleoside recognition; Region: Gate; pfam07670
552536001480	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
552536001481	Nucleoside recognition; Region: Gate; pfam07670
552536001482	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
552536001483	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
552536001484	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
552536001485	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
552536001486	predicted active site [active]
552536001487	catalytic triad [active]
552536001488	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
552536001489	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
552536001490	active site
552536001491	multimer interface [polypeptide binding]; other site
552536001492	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
552536001493	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536001494	DNA-binding site [nucleotide binding]; DNA binding site
552536001495	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536001496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536001497	homodimer interface [polypeptide binding]; other site
552536001498	catalytic residue [active]
552536001499	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536001500	PRD domain; Region: PRD; pfam00874
552536001501	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536001502	active site
552536001503	P-loop; other site
552536001504	phosphorylation site [posttranslational modification]
552536001505	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
552536001506	active site
552536001507	phosphorylation site [posttranslational modification]
552536001508	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536001509	active site
552536001510	phosphorylation site [posttranslational modification]
552536001511	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
552536001512	active site
552536001513	P-loop; other site
552536001514	phosphorylation site [posttranslational modification]
552536001515	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
552536001516	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
552536001517	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
552536001518	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
552536001519	putative substrate binding site [chemical binding]; other site
552536001520	putative ATP binding site [chemical binding]; other site
552536001521	hypothetical protein; Provisional; Region: PRK06357
552536001522	active site
552536001523	intersubunit interface [polypeptide binding]; other site
552536001524	Zn2+ binding site [ion binding]; other site
552536001525	BCCT family transporter; Region: BCCT; pfam02028
552536001526	argininosuccinate lyase; Provisional; Region: PRK00855
552536001527	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
552536001528	active sites [active]
552536001529	tetramer interface [polypeptide binding]; other site
552536001530	argininosuccinate synthase; Provisional; Region: PRK13820
552536001531	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
552536001532	ANP binding site [chemical binding]; other site
552536001533	Substrate Binding Site II [chemical binding]; other site
552536001534	Substrate Binding Site I [chemical binding]; other site
552536001535	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
552536001536	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
552536001537	substrate binding pocket [chemical binding]; other site
552536001538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536001539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536001540	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
552536001541	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
552536001542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536001543	non-specific DNA binding site [nucleotide binding]; other site
552536001544	salt bridge; other site
552536001545	sequence-specific DNA binding site [nucleotide binding]; other site
552536001546	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001547	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001548	Cna protein B-type domain; Region: Cna_B; pfam05738
552536001549	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536001550	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536001551	non-specific DNA binding site [nucleotide binding]; other site
552536001552	salt bridge; other site
552536001553	sequence-specific DNA binding site [nucleotide binding]; other site
552536001554	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
552536001555	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
552536001556	catalytic residues [active]
552536001557	catalytic nucleophile [active]
552536001558	Presynaptic Site I dimer interface [polypeptide binding]; other site
552536001559	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
552536001560	Synaptic Flat tetramer interface [polypeptide binding]; other site
552536001561	Synaptic Site I dimer interface [polypeptide binding]; other site
552536001562	DNA binding site [nucleotide binding]
552536001563	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536001564	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552536001565	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552536001566	active site
552536001567	ATP binding site [chemical binding]; other site
552536001568	substrate binding site [chemical binding]; other site
552536001569	activation loop (A-loop); other site
552536001570	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
552536001571	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
552536001572	active site
552536001573	DNA binding site [nucleotide binding]
552536001574	Int/Topo IB signature motif; other site
552536001575	Phosphotransferase enzyme family; Region: APH; pfam01636
552536001576	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
552536001577	active site
552536001578	substrate binding site [chemical binding]; other site
552536001579	ATP binding site [chemical binding]; other site
552536001580	Uncharacterized conserved protein [Function unknown]; Region: COG4832
552536001581	camphor resistance protein CrcB; Provisional; Region: PRK14231
552536001582	camphor resistance protein CrcB; Provisional; Region: PRK14214
552536001583	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
552536001584	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
552536001585	Glycoprotease family; Region: Peptidase_M22; pfam00814
552536001586	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
552536001587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536001588	Coenzyme A binding pocket [chemical binding]; other site
552536001589	UGMP family protein; Validated; Region: PRK09604
552536001590	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
552536001591	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552536001592	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552536001593	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
552536001594	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536001595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536001596	Q-loop/lid; other site
552536001597	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536001598	ABC transporter signature motif; other site
552536001599	Walker B; other site
552536001600	D-loop; other site
552536001601	ABC transporter; Region: ABC_tran_2; pfam12848
552536001602	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536001603	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
552536001604	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
552536001605	CoA binding domain; Region: CoA_binding; pfam02629
552536001606	CAAX protease self-immunity; Region: Abi; pfam02517
552536001607	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
552536001608	oligomerisation interface [polypeptide binding]; other site
552536001609	mobile loop; other site
552536001610	roof hairpin; other site
552536001611	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
552536001612	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
552536001613	ring oligomerisation interface [polypeptide binding]; other site
552536001614	ATP/Mg binding site [chemical binding]; other site
552536001615	stacking interactions; other site
552536001616	hinge regions; other site
552536001617	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
552536001618	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
552536001619	active site
552536001620	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
552536001621	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
552536001622	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
552536001623	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
552536001624	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
552536001625	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
552536001626	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
552536001627	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
552536001628	MOSC domain; Region: MOSC; pfam03473
552536001629	3-alpha domain; Region: 3-alpha; pfam03475
552536001630	Ion transport protein; Region: Ion_trans; pfam00520
552536001631	Ion channel; Region: Ion_trans_2; pfam07885
552536001632	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
552536001633	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
552536001634	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
552536001635	UbiA prenyltransferase family; Region: UbiA; pfam01040
552536001636	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
552536001637	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
552536001638	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
552536001639	hypothetical protein; Provisional; Region: PRK02886
552536001640	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
552536001641	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536001642	S-adenosylmethionine binding site [chemical binding]; other site
552536001643	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
552536001644	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
552536001645	active site
552536001646	(T/H)XGH motif; other site
552536001647	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
552536001648	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
552536001649	protein binding site [polypeptide binding]; other site
552536001650	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
552536001651	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552536001652	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552536001653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536001654	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14267
552536001655	Walker A/P-loop; other site
552536001656	ATP binding site [chemical binding]; other site
552536001657	Q-loop/lid; other site
552536001658	ABC transporter signature motif; other site
552536001659	Walker B; other site
552536001660	D-loop; other site
552536001661	H-loop/switch region; other site
552536001662	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
552536001663	hypothetical protein; Provisional; Region: PRK13670
552536001664	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
552536001665	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
552536001666	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
552536001667	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
552536001668	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
552536001669	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
552536001670	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
552536001671	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
552536001672	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536001673	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536001674	putative substrate translocation pore; other site
552536001675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
552536001676	MraZ protein; Region: MraZ; pfam02381
552536001677	MraZ protein; Region: MraZ; pfam02381
552536001678	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
552536001679	MraW methylase family; Region: Methyltransf_5; pfam01795
552536001680	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
552536001681	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
552536001682	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
552536001683	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552536001684	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
552536001685	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
552536001686	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
552536001687	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552536001688	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552536001689	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
552536001690	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552536001691	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
552536001692	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
552536001693	Mg++ binding site [ion binding]; other site
552536001694	putative catalytic motif [active]
552536001695	putative substrate binding site [chemical binding]; other site
552536001696	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
552536001697	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552536001698	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552536001699	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
552536001700	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
552536001701	active site
552536001702	homodimer interface [polypeptide binding]; other site
552536001703	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
552536001704	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
552536001705	Cell division protein FtsQ; Region: FtsQ; pfam03799
552536001706	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
552536001707	Cell division protein FtsA; Region: FtsA; smart00842
552536001708	Cell division protein FtsA; Region: FtsA; pfam14450
552536001709	cell division protein FtsZ; Validated; Region: PRK09330
552536001710	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
552536001711	nucleotide binding site [chemical binding]; other site
552536001712	SulA interaction site; other site
552536001713	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
552536001714	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552536001715	catalytic residue [active]
552536001716	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
552536001717	YGGT family; Region: YGGT; pfam02325
552536001718	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
552536001719	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536001720	RNA binding surface [nucleotide binding]; other site
552536001721	quinolinate synthetase; Provisional; Region: PRK09375
552536001722	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
552536001723	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
552536001724	dimerization interface [polypeptide binding]; other site
552536001725	active site
552536001726	L-aspartate oxidase; Provisional; Region: PRK08071
552536001727	L-aspartate oxidase; Provisional; Region: PRK06175
552536001728	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
552536001729	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
552536001730	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
552536001731	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536001732	catalytic residue [active]
552536001733	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
552536001734	HTH domain; Region: HTH_11; pfam08279
552536001735	3H domain; Region: 3H; pfam02829
552536001736	DivIVA protein; Region: DivIVA; pfam05103
552536001737	DivIVA domain; Region: DivI1A_domain; TIGR03544
552536001738	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
552536001739	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
552536001740	HIGH motif; other site
552536001741	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
552536001742	active site
552536001743	KMSKS motif; other site
552536001744	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
552536001745	tRNA binding surface [nucleotide binding]; other site
552536001746	anticodon binding site; other site
552536001747	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
552536001748	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
552536001749	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
552536001750	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
552536001751	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
552536001752	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
552536001753	active site
552536001754	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
552536001755	DNA-binding site [nucleotide binding]; DNA binding site
552536001756	RNA-binding motif; other site
552536001757	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
552536001758	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
552536001759	active site
552536001760	catalytic site [active]
552536001761	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
552536001762	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
552536001763	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
552536001764	active site
552536001765	metal binding site [ion binding]; metal-binding site
552536001766	homodimer interface [polypeptide binding]; other site
552536001767	catalytic site [active]
552536001768	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
552536001769	Uncharacterized conserved protein [Function unknown]; Region: COG3538
552536001770	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
552536001771	Predicted integral membrane protein [Function unknown]; Region: COG5578
552536001772	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
552536001773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536001774	dimerization interface [polypeptide binding]; other site
552536001775	Histidine kinase; Region: His_kinase; pfam06580
552536001776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536001777	ATP binding site [chemical binding]; other site
552536001778	Mg2+ binding site [ion binding]; other site
552536001779	G-X-G motif; other site
552536001780	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
552536001781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536001782	active site
552536001783	phosphorylation site [posttranslational modification]
552536001784	intermolecular recognition site; other site
552536001785	dimerization interface [polypeptide binding]; other site
552536001786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536001787	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
552536001788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001789	dimer interface [polypeptide binding]; other site
552536001790	conserved gate region; other site
552536001791	ABC-ATPase subunit interface; other site
552536001792	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536001793	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536001794	dimer interface [polypeptide binding]; other site
552536001795	conserved gate region; other site
552536001796	ABC-ATPase subunit interface; other site
552536001797	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536001798	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
552536001799	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
552536001800	acetolactate synthase; Reviewed; Region: PRK08617
552536001801	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
552536001802	PYR/PP interface [polypeptide binding]; other site
552536001803	dimer interface [polypeptide binding]; other site
552536001804	TPP binding site [chemical binding]; other site
552536001805	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552536001806	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
552536001807	TPP-binding site [chemical binding]; other site
552536001808	dimer interface [polypeptide binding]; other site
552536001809	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536001810	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536001811	active site
552536001812	catalytic tetrad [active]
552536001813	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536001814	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536001815	DNA-binding site [nucleotide binding]; DNA binding site
552536001816	UTRA domain; Region: UTRA; pfam07702
552536001817	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536001818	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536001819	DNA-binding site [nucleotide binding]; DNA binding site
552536001820	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
552536001821	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
552536001822	active site
552536001823	phosphorylation site [posttranslational modification]
552536001824	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
552536001825	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
552536001826	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
552536001827	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
552536001828	dimer interface [polypeptide binding]; other site
552536001829	active site
552536001830	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
552536001831	dimer interface [polypeptide binding]; other site
552536001832	active site
552536001833	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
552536001834	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
552536001835	putative active site [active]
552536001836	SIS domain; Region: SIS; pfam01380
552536001837	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536001838	active pocket/dimerization site; other site
552536001839	active site
552536001840	phosphorylation site [posttranslational modification]
552536001841	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
552536001842	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
552536001843	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
552536001844	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
552536001845	intersubunit interface [polypeptide binding]; other site
552536001846	active site
552536001847	catalytic residue [active]
552536001848	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536001849	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536001850	DNA binding site [nucleotide binding]
552536001851	domain linker motif; other site
552536001852	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552536001853	dimerization interface [polypeptide binding]; other site
552536001854	ligand binding site [chemical binding]; other site
552536001855	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
552536001856	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
552536001857	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
552536001858	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
552536001859	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
552536001860	threonine dehydratase; Validated; Region: PRK08639
552536001861	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
552536001862	tetramer interface [polypeptide binding]; other site
552536001863	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536001864	catalytic residue [active]
552536001865	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
552536001866	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
552536001867	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
552536001868	substrate binding site [chemical binding]; other site
552536001869	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
552536001870	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
552536001871	substrate binding site [chemical binding]; other site
552536001872	ligand binding site [chemical binding]; other site
552536001873	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
552536001874	tartrate dehydrogenase; Region: TTC; TIGR02089
552536001875	2-isopropylmalate synthase; Validated; Region: PRK00915
552536001876	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
552536001877	active site
552536001878	catalytic residues [active]
552536001879	metal binding site [ion binding]; metal-binding site
552536001880	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
552536001881	ketol-acid reductoisomerase; Provisional; Region: PRK05479
552536001882	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
552536001883	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
552536001884	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
552536001885	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
552536001886	putative valine binding site [chemical binding]; other site
552536001887	dimer interface [polypeptide binding]; other site
552536001888	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
552536001889	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
552536001890	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
552536001891	PYR/PP interface [polypeptide binding]; other site
552536001892	dimer interface [polypeptide binding]; other site
552536001893	TPP binding site [chemical binding]; other site
552536001894	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552536001895	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
552536001896	TPP-binding site [chemical binding]; other site
552536001897	dimer interface [polypeptide binding]; other site
552536001898	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
552536001899	6-phosphogluconate dehydratase; Region: edd; TIGR01196
552536001900	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552536001901	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536001902	Coenzyme A binding pocket [chemical binding]; other site
552536001903	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
552536001904	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
552536001905	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
552536001906	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
552536001907	ribonuclease Z; Region: RNase_Z; TIGR02651
552536001908	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
552536001909	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552536001910	NAD(P) binding site [chemical binding]; other site
552536001911	active site
552536001912	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
552536001913	active site
552536001914	DNA polymerase IV; Validated; Region: PRK02406
552536001915	DNA binding site [nucleotide binding]
552536001916	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
552536001917	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
552536001918	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
552536001919	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
552536001920	dimer interface [polypeptide binding]; other site
552536001921	ADP-ribose binding site [chemical binding]; other site
552536001922	active site
552536001923	nudix motif; other site
552536001924	metal binding site [ion binding]; metal-binding site
552536001925	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536001926	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552536001927	Walker A/P-loop; other site
552536001928	ATP binding site [chemical binding]; other site
552536001929	Q-loop/lid; other site
552536001930	ABC transporter signature motif; other site
552536001931	Walker B; other site
552536001932	D-loop; other site
552536001933	H-loop/switch region; other site
552536001934	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
552536001935	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552536001936	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536001937	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536001938	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
552536001939	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536001940	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
552536001941	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
552536001942	Walker A/P-loop; other site
552536001943	ATP binding site [chemical binding]; other site
552536001944	Q-loop/lid; other site
552536001945	ABC transporter signature motif; other site
552536001946	Walker B; other site
552536001947	D-loop; other site
552536001948	H-loop/switch region; other site
552536001949	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
552536001950	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
552536001951	putative ligand binding residues [chemical binding]; other site
552536001952	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
552536001953	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536001954	ABC-ATPase subunit  interface; other site
552536001955	dimer interface [polypeptide binding]; other site
552536001956	putative PBP binding regions; other site
552536001957	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
552536001958	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536001959	ABC-ATPase subunit  interface; other site
552536001960	dimer interface [polypeptide binding]; other site
552536001961	putative PBP binding regions; other site
552536001962	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
552536001963	metal binding site 2 [ion binding]; metal-binding site
552536001964	putative DNA binding helix; other site
552536001965	metal binding site 1 [ion binding]; metal-binding site
552536001966	dimer interface [polypeptide binding]; other site
552536001967	structural Zn2+ binding site [ion binding]; other site
552536001968	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
552536001969	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
552536001970	active site
552536001971	Int/Topo IB signature motif; other site
552536001972	phosphopentomutase; Provisional; Region: PRK05362
552536001973	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
552536001974	purine nucleoside phosphorylase; Provisional; Region: PRK08202
552536001975	diaminopimelate decarboxylase; Region: lysA; TIGR01048
552536001976	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
552536001977	active site
552536001978	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552536001979	substrate binding site [chemical binding]; other site
552536001980	catalytic residues [active]
552536001981	dimer interface [polypeptide binding]; other site
552536001982	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
552536001983	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
552536001984	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
552536001985	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536001986	RNA binding surface [nucleotide binding]; other site
552536001987	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
552536001988	active site
552536001989	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536001990	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536001991	active site
552536001992	phosphorylation site [posttranslational modification]
552536001993	intermolecular recognition site; other site
552536001994	dimerization interface [polypeptide binding]; other site
552536001995	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536001996	DNA binding site [nucleotide binding]
552536001997	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
552536001998	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536001999	dimerization interface [polypeptide binding]; other site
552536002000	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536002001	dimer interface [polypeptide binding]; other site
552536002002	phosphorylation site [posttranslational modification]
552536002003	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536002004	ATP binding site [chemical binding]; other site
552536002005	Mg2+ binding site [ion binding]; other site
552536002006	G-X-G motif; other site
552536002007	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
552536002008	Predicted membrane protein [Function unknown]; Region: COG3601
552536002009	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
552536002010	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
552536002011	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
552536002012	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552536002013	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536002014	ATP binding site [chemical binding]; other site
552536002015	putative Mg++ binding site [ion binding]; other site
552536002016	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536002017	nucleotide binding region [chemical binding]; other site
552536002018	ATP-binding site [chemical binding]; other site
552536002019	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536002020	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
552536002021	active site
552536002022	homotetramer interface [polypeptide binding]; other site
552536002023	homodimer interface [polypeptide binding]; other site
552536002024	cytidylate kinase; Provisional; Region: cmk; PRK00023
552536002025	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
552536002026	CMP-binding site; other site
552536002027	The sites determining sugar specificity; other site
552536002028	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
552536002029	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
552536002030	RNA binding site [nucleotide binding]; other site
552536002031	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
552536002032	RNA binding site [nucleotide binding]; other site
552536002033	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
552536002034	RNA binding site [nucleotide binding]; other site
552536002035	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
552536002036	RNA binding site [nucleotide binding]; other site
552536002037	GTP-binding protein Der; Reviewed; Region: PRK00093
552536002038	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
552536002039	G1 box; other site
552536002040	GTP/Mg2+ binding site [chemical binding]; other site
552536002041	Switch I region; other site
552536002042	G2 box; other site
552536002043	Switch II region; other site
552536002044	G3 box; other site
552536002045	G4 box; other site
552536002046	G5 box; other site
552536002047	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
552536002048	G1 box; other site
552536002049	GTP/Mg2+ binding site [chemical binding]; other site
552536002050	Switch I region; other site
552536002051	G2 box; other site
552536002052	G3 box; other site
552536002053	Switch II region; other site
552536002054	G4 box; other site
552536002055	G5 box; other site
552536002056	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
552536002057	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
552536002058	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
552536002059	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
552536002060	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
552536002061	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
552536002062	IHF dimer interface [polypeptide binding]; other site
552536002063	IHF - DNA interface [nucleotide binding]; other site
552536002064	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
552536002065	homodecamer interface [polypeptide binding]; other site
552536002066	GTP cyclohydrolase I; Provisional; Region: PLN03044
552536002067	active site
552536002068	putative catalytic site residues [active]
552536002069	zinc binding site [ion binding]; other site
552536002070	GTP-CH-I/GFRP interaction surface; other site
552536002071	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
552536002072	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
552536002073	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536002074	S-adenosylmethionine binding site [chemical binding]; other site
552536002075	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
552536002076	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
552536002077	substrate binding pocket [chemical binding]; other site
552536002078	chain length determination region; other site
552536002079	substrate-Mg2+ binding site; other site
552536002080	catalytic residues [active]
552536002081	aspartate-rich region 1; other site
552536002082	active site lid residues [active]
552536002083	aspartate-rich region 2; other site
552536002084	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
552536002085	active site
552536002086	multimer interface [polypeptide binding]; other site
552536002087	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
552536002088	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
552536002089	Tetramer interface [polypeptide binding]; other site
552536002090	active site
552536002091	FMN-binding site [chemical binding]; other site
552536002092	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
552536002093	active site
552536002094	dimer interface [polypeptide binding]; other site
552536002095	metal binding site [ion binding]; metal-binding site
552536002096	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
552536002097	homotrimer interaction site [polypeptide binding]; other site
552536002098	active site
552536002099	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
552536002100	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536002101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536002102	homodimer interface [polypeptide binding]; other site
552536002103	catalytic residue [active]
552536002104	prephenate dehydrogenase; Validated; Region: PRK06545
552536002105	prephenate dehydrogenase; Validated; Region: PRK08507
552536002106	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
552536002107	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
552536002108	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
552536002109	hinge; other site
552536002110	active site
552536002111	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
552536002112	binding surface
552536002113	TPR motif; other site
552536002114	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536002115	binding surface
552536002116	Tetratricopeptide repeat; Region: TPR_16; pfam13432
552536002117	TPR motif; other site
552536002118	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
552536002119	binding surface
552536002120	TPR motif; other site
552536002121	hypothetical protein; Provisional; Region: PRK03636
552536002122	UPF0302 domain; Region: UPF0302; pfam08864
552536002123	IDEAL domain; Region: IDEAL; pfam08858
552536002124	Predicted membrane protein [Function unknown]; Region: COG4347
552536002125	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
552536002126	HI0933-like protein; Region: HI0933_like; pfam03486
552536002127	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552536002128	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
552536002129	Pyruvate formate lyase 1; Region: PFL1; cd01678
552536002130	coenzyme A binding site [chemical binding]; other site
552536002131	active site
552536002132	catalytic residues [active]
552536002133	glycine loop; other site
552536002134	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
552536002135	Beta-lactamase; Region: Beta-lactamase; pfam00144
552536002136	malate dehydrogenase; Provisional; Region: PRK13529
552536002137	Malic enzyme, N-terminal domain; Region: malic; pfam00390
552536002138	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
552536002139	NAD(P) binding pocket [chemical binding]; other site
552536002140	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
552536002141	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
552536002142	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
552536002143	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
552536002144	metal binding site [ion binding]; metal-binding site
552536002145	active site
552536002146	I-site; other site
552536002147	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
552536002148	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
552536002149	metal binding site [ion binding]; metal-binding site
552536002150	active site
552536002151	I-site; other site
552536002152	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
552536002153	Uncharacterized conserved protein [Function unknown]; Region: COG1284
552536002154	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536002155	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536002156	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536002157	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
552536002158	homodimer interface [polypeptide binding]; other site
552536002159	metal binding site [ion binding]; metal-binding site
552536002160	dihydrodipicolinate reductase; Provisional; Region: PRK00048
552536002161	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
552536002162	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
552536002163	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
552536002164	active site
552536002165	dimer interfaces [polypeptide binding]; other site
552536002166	catalytic residues [active]
552536002167	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
552536002168	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
552536002169	active site
552536002170	NTP binding site [chemical binding]; other site
552536002171	metal binding triad [ion binding]; metal-binding site
552536002172	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
552536002173	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
552536002174	Biotin operon repressor [Transcription]; Region: BirA; COG1654
552536002175	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
552536002176	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
552536002177	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
552536002178	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536002179	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
552536002180	catalytic residues [active]
552536002181	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
552536002182	active site
552536002183	oligomerization interface [polypeptide binding]; other site
552536002184	metal binding site [ion binding]; metal-binding site
552536002185	pantoate--beta-alanine ligase; Region: panC; TIGR00018
552536002186	Pantoate-beta-alanine ligase; Region: PanC; cd00560
552536002187	active site
552536002188	ATP-binding site [chemical binding]; other site
552536002189	pantoate-binding site; other site
552536002190	HXXH motif; other site
552536002191	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
552536002192	tetramerization interface [polypeptide binding]; other site
552536002193	active site
552536002194	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
552536002195	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
552536002196	active site
552536002197	catalytic site [active]
552536002198	substrate binding site [chemical binding]; other site
552536002199	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
552536002200	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536002201	putative Mg++ binding site [ion binding]; other site
552536002202	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
552536002203	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
552536002204	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
552536002205	aspartate aminotransferase; Provisional; Region: PRK05764
552536002206	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536002207	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536002208	homodimer interface [polypeptide binding]; other site
552536002209	catalytic residue [active]
552536002210	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
552536002211	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
552536002212	putative dimer interface [polypeptide binding]; other site
552536002213	putative anticodon binding site; other site
552536002214	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
552536002215	homodimer interface [polypeptide binding]; other site
552536002216	motif 1; other site
552536002217	motif 2; other site
552536002218	active site
552536002219	motif 3; other site
552536002220	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
552536002221	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
552536002222	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
552536002223	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
552536002224	minor groove reading motif; other site
552536002225	helix-hairpin-helix signature motif; other site
552536002226	substrate binding pocket [chemical binding]; other site
552536002227	active site
552536002228	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
552536002229	Transglycosylase; Region: Transgly; pfam00912
552536002230	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
552536002231	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552536002232	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
552536002233	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
552536002234	hypothetical protein; Provisional; Region: PRK13660
552536002235	cell division protein GpsB; Provisional; Region: PRK14127
552536002236	DivIVA domain; Region: DivI1A_domain; TIGR03544
552536002237	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
552536002238	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
552536002239	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
552536002240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
552536002241	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
552536002242	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
552536002243	active site
552536002244	Zn binding site [ion binding]; other site
552536002245	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536002246	active site
552536002247	xanthine permease; Region: pbuX; TIGR03173
552536002248	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
552536002249	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
552536002250	putative active site [active]
552536002251	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
552536002252	5'-3' exonuclease; Region: 53EXOc; smart00475
552536002253	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
552536002254	active site
552536002255	metal binding site 1 [ion binding]; metal-binding site
552536002256	putative 5' ssDNA interaction site; other site
552536002257	metal binding site 3; metal-binding site
552536002258	metal binding site 2 [ion binding]; metal-binding site
552536002259	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
552536002260	putative DNA binding site [nucleotide binding]; other site
552536002261	putative metal binding site [ion binding]; other site
552536002262	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
552536002263	RNA/DNA hybrid binding site [nucleotide binding]; other site
552536002264	active site
552536002265	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
552536002266	DNA-binding site [nucleotide binding]; DNA binding site
552536002267	RNA-binding motif; other site
552536002268	manganese transport transcriptional regulator; Provisional; Region: PRK03902
552536002269	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
552536002270	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
552536002271	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
552536002272	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
552536002273	Potassium binding sites [ion binding]; other site
552536002274	Cesium cation binding sites [ion binding]; other site
552536002275	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
552536002276	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552536002277	Walker A/P-loop; other site
552536002278	ATP binding site [chemical binding]; other site
552536002279	Q-loop/lid; other site
552536002280	ABC transporter signature motif; other site
552536002281	Walker B; other site
552536002282	D-loop; other site
552536002283	H-loop/switch region; other site
552536002284	ABC transporter; Region: ABC_tran_2; pfam12848
552536002285	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536002286	thymidylate synthase; Region: thym_sym; TIGR03284
552536002287	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
552536002288	dimerization interface [polypeptide binding]; other site
552536002289	active site
552536002290	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
552536002291	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
552536002292	folate binding site [chemical binding]; other site
552536002293	NADP+ binding site [chemical binding]; other site
552536002294	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
552536002295	Methyltransferase domain; Region: Methyltransf_11; pfam08241
552536002296	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
552536002297	active site
552536002298	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
552536002299	substrate binding site [chemical binding]; other site
552536002300	metal binding site [ion binding]; metal-binding site
552536002301	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
552536002302	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
552536002303	Predicted membrane protein [Function unknown]; Region: COG4129
552536002304	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
552536002305	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
552536002306	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536002307	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
552536002308	pyruvate phosphate dikinase; Provisional; Region: PRK09279
552536002309	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
552536002310	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
552536002311	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
552536002312	PEP synthetase regulatory protein; Provisional; Region: PRK05339
552536002313	HTH domain; Region: HTH_11; pfam08279
552536002314	FOG: CBS domain [General function prediction only]; Region: COG0517
552536002315	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
552536002316	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
552536002317	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
552536002318	EDD domain protein, DegV family; Region: DegV; TIGR00762
552536002319	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
552536002320	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
552536002321	active site
552536002322	catalytic triad [active]
552536002323	oxyanion hole [active]
552536002324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
552536002325	methionine sulfoxide reductase A; Provisional; Region: PRK14054
552536002326	methionine sulfoxide reductase B; Provisional; Region: PRK00222
552536002327	SelR domain; Region: SelR; pfam01641
552536002328	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536002329	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536002330	hypothetical protein; Provisional; Region: PRK13672
552536002331	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
552536002332	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
552536002333	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
552536002334	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
552536002335	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
552536002336	putative homodimer interface [polypeptide binding]; other site
552536002337	putative homotetramer interface [polypeptide binding]; other site
552536002338	putative allosteric switch controlling residues; other site
552536002339	putative metal binding site [ion binding]; other site
552536002340	putative homodimer-homodimer interface [polypeptide binding]; other site
552536002341	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
552536002342	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
552536002343	metal-binding site [ion binding]
552536002344	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536002345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536002346	motif II; other site
552536002347	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
552536002348	metal-binding site [ion binding]
552536002349	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
552536002350	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
552536002351	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
552536002352	protein binding site [polypeptide binding]; other site
552536002353	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
552536002354	Catalytic dyad [active]
552536002355	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
552536002356	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536002357	MarR family; Region: MarR; pfam01047
552536002358	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
552536002359	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
552536002360	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
552536002361	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536002362	ABC-ATPase subunit  interface; other site
552536002363	dimer interface [polypeptide binding]; other site
552536002364	putative PBP binding regions; other site
552536002365	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
552536002366	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
552536002367	metal binding site [ion binding]; metal-binding site
552536002368	multidrug efflux protein; Reviewed; Region: PRK01766
552536002369	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
552536002370	cation binding site [ion binding]; other site
552536002371	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
552536002372	Sulfate transporter family; Region: Sulfate_transp; pfam00916
552536002373	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
552536002374	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
552536002375	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536002376	RNA binding surface [nucleotide binding]; other site
552536002377	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
552536002378	active site
552536002379	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536002380	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
552536002381	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536002382	active site
552536002383	uracil transporter; Provisional; Region: PRK10720
552536002384	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
552536002385	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
552536002386	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
552536002387	dihydroorotase; Validated; Region: pyrC; PRK09357
552536002388	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
552536002389	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
552536002390	active site
552536002391	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
552536002392	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
552536002393	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
552536002394	catalytic site [active]
552536002395	subunit interface [polypeptide binding]; other site
552536002396	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
552536002397	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552536002398	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
552536002399	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
552536002400	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552536002401	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552536002402	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
552536002403	IMP binding site; other site
552536002404	dimer interface [polypeptide binding]; other site
552536002405	interdomain contacts; other site
552536002406	partial ornithine binding site; other site
552536002407	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
552536002408	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
552536002409	FAD binding pocket [chemical binding]; other site
552536002410	FAD binding motif [chemical binding]; other site
552536002411	phosphate binding motif [ion binding]; other site
552536002412	beta-alpha-beta structure motif; other site
552536002413	NAD binding pocket [chemical binding]; other site
552536002414	Iron coordination center [ion binding]; other site
552536002415	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
552536002416	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
552536002417	heterodimer interface [polypeptide binding]; other site
552536002418	active site
552536002419	FMN binding site [chemical binding]; other site
552536002420	homodimer interface [polypeptide binding]; other site
552536002421	substrate binding site [chemical binding]; other site
552536002422	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
552536002423	active site
552536002424	dimer interface [polypeptide binding]; other site
552536002425	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536002426	active site
552536002427	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
552536002428	putative NAD(P) binding site [chemical binding]; other site
552536002429	homodimer interface [polypeptide binding]; other site
552536002430	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
552536002431	Domain of unknown function (DUF814); Region: DUF814; pfam05670
552536002432	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
552536002433	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
552536002434	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
552536002435	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
552536002436	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
552536002437	catalytic site [active]
552536002438	G-X2-G-X-G-K; other site
552536002439	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
552536002440	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
552536002441	Flavoprotein; Region: Flavoprotein; pfam02441
552536002442	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
552536002443	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
552536002444	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536002445	ATP binding site [chemical binding]; other site
552536002446	putative Mg++ binding site [ion binding]; other site
552536002447	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536002448	ATP-binding site [chemical binding]; other site
552536002449	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
552536002450	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
552536002451	putative active site [active]
552536002452	substrate binding site [chemical binding]; other site
552536002453	putative cosubstrate binding site; other site
552536002454	catalytic site [active]
552536002455	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
552536002456	substrate binding site [chemical binding]; other site
552536002457	16S rRNA methyltransferase B; Provisional; Region: PRK14902
552536002458	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
552536002459	putative RNA binding site [nucleotide binding]; other site
552536002460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536002461	S-adenosylmethionine binding site [chemical binding]; other site
552536002462	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
552536002463	Protein phosphatase 2C; Region: PP2C; pfam00481
552536002464	active site
552536002465	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
552536002466	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552536002467	active site
552536002468	ATP binding site [chemical binding]; other site
552536002469	substrate binding site [chemical binding]; other site
552536002470	activation loop (A-loop); other site
552536002471	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
552536002472	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552536002473	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552536002474	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552536002475	GTPase RsgA; Reviewed; Region: PRK00098
552536002476	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
552536002477	RNA binding site [nucleotide binding]; other site
552536002478	homodimer interface [polypeptide binding]; other site
552536002479	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
552536002480	GTPase/Zn-binding domain interface [polypeptide binding]; other site
552536002481	GTP/Mg2+ binding site [chemical binding]; other site
552536002482	G4 box; other site
552536002483	G1 box; other site
552536002484	Switch I region; other site
552536002485	G2 box; other site
552536002486	G3 box; other site
552536002487	Switch II region; other site
552536002488	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552536002489	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552536002490	substrate binding site [chemical binding]; other site
552536002491	hexamer interface [polypeptide binding]; other site
552536002492	metal binding site [ion binding]; metal-binding site
552536002493	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
552536002494	Thiamine pyrophosphokinase; Region: TPK; cd07995
552536002495	active site
552536002496	dimerization interface [polypeptide binding]; other site
552536002497	thiamine binding site [chemical binding]; other site
552536002498	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
552536002499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
552536002500	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
552536002501	DAK2 domain; Region: Dak2; pfam02734
552536002502	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
552536002503	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
552536002504	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
552536002505	putative L-serine binding site [chemical binding]; other site
552536002506	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
552536002507	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
552536002508	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
552536002509	Y-family of DNA polymerases; Region: PolY; cl12025
552536002510	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
552536002511	generic binding surface II; other site
552536002512	ssDNA binding site; other site
552536002513	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536002514	ATP binding site [chemical binding]; other site
552536002515	putative Mg++ binding site [ion binding]; other site
552536002516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536002517	nucleotide binding region [chemical binding]; other site
552536002518	ATP-binding site [chemical binding]; other site
552536002519	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
552536002520	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
552536002521	active site 2 [active]
552536002522	active site 1 [active]
552536002523	putative phosphate acyltransferase; Provisional; Region: PRK05331
552536002524	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
552536002525	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
552536002526	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
552536002527	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
552536002528	NAD(P) binding site [chemical binding]; other site
552536002529	homotetramer interface [polypeptide binding]; other site
552536002530	homodimer interface [polypeptide binding]; other site
552536002531	active site
552536002532	acyl carrier protein; Provisional; Region: acpP; PRK00982
552536002533	ribonuclease III; Reviewed; Region: rnc; PRK00102
552536002534	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
552536002535	dimerization interface [polypeptide binding]; other site
552536002536	active site
552536002537	metal binding site [ion binding]; metal-binding site
552536002538	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
552536002539	dsRNA binding site [nucleotide binding]; other site
552536002540	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
552536002541	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
552536002542	Walker A/P-loop; other site
552536002543	ATP binding site [chemical binding]; other site
552536002544	Q-loop/lid; other site
552536002545	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
552536002546	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
552536002547	linker region; other site
552536002548	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
552536002549	ABC transporter signature motif; other site
552536002550	Walker B; other site
552536002551	D-loop; other site
552536002552	H-loop/switch region; other site
552536002553	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
552536002554	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
552536002555	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
552536002556	P loop; other site
552536002557	GTP binding site [chemical binding]; other site
552536002558	putative DNA-binding protein; Validated; Region: PRK00118
552536002559	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
552536002560	signal recognition particle protein; Provisional; Region: PRK10867
552536002561	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
552536002562	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
552536002563	P loop; other site
552536002564	GTP binding site [chemical binding]; other site
552536002565	Signal peptide binding domain; Region: SRP_SPB; pfam02978
552536002566	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
552536002567	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
552536002568	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
552536002569	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
552536002570	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
552536002571	KH domain; Region: KH_4; pfam13083
552536002572	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
552536002573	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
552536002574	catalytic triad [active]
552536002575	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
552536002576	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
552536002577	RimM N-terminal domain; Region: RimM; pfam01782
552536002578	PRC-barrel domain; Region: PRC; pfam05239
552536002579	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
552536002580	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
552536002581	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536002582	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
552536002583	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552536002584	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
552536002585	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552536002586	DNA binding residues [nucleotide binding]
552536002587	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
552536002588	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
552536002589	active site
552536002590	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
552536002591	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
552536002592	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
552536002593	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
552536002594	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
552536002595	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
552536002596	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
552536002597	23S rRNA binding site [nucleotide binding]; other site
552536002598	L21 binding site [polypeptide binding]; other site
552536002599	L13 binding site [polypeptide binding]; other site
552536002600	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
552536002601	active site
552536002602	putative catalytic site [active]
552536002603	DNA binding site [nucleotide binding]
552536002604	putative phosphate binding site [ion binding]; other site
552536002605	metal binding site A [ion binding]; metal-binding site
552536002606	AP binding site [nucleotide binding]; other site
552536002607	metal binding site B [ion binding]; metal-binding site
552536002608	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
552536002609	peptidase T; Region: peptidase-T; TIGR01882
552536002610	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
552536002611	metal binding site [ion binding]; metal-binding site
552536002612	dimer interface [polypeptide binding]; other site
552536002613	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
552536002614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
552536002615	Walker A/P-loop; other site
552536002616	ATP binding site [chemical binding]; other site
552536002617	Q-loop/lid; other site
552536002618	ABC transporter signature motif; other site
552536002619	Walker B; other site
552536002620	D-loop; other site
552536002621	H-loop/switch region; other site
552536002622	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
552536002623	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536002624	Zn2+ binding site [ion binding]; other site
552536002625	Mg2+ binding site [ion binding]; other site
552536002626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
552536002627	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536002628	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
552536002629	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
552536002630	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
552536002631	NAD binding site [chemical binding]; other site
552536002632	ATP-grasp domain; Region: ATP-grasp; pfam02222
552536002633	adenylosuccinate lyase; Provisional; Region: PRK07492
552536002634	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
552536002635	tetramer interface [polypeptide binding]; other site
552536002636	active site
552536002637	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
552536002638	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
552536002639	ATP binding site [chemical binding]; other site
552536002640	active site
552536002641	substrate binding site [chemical binding]; other site
552536002642	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
552536002643	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
552536002644	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
552536002645	putative active site [active]
552536002646	catalytic triad [active]
552536002647	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
552536002648	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
552536002649	dimerization interface [polypeptide binding]; other site
552536002650	ATP binding site [chemical binding]; other site
552536002651	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
552536002652	dimerization interface [polypeptide binding]; other site
552536002653	ATP binding site [chemical binding]; other site
552536002654	amidophosphoribosyltransferase; Provisional; Region: PRK06781
552536002655	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
552536002656	active site
552536002657	tetramer interface [polypeptide binding]; other site
552536002658	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536002659	active site
552536002660	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
552536002661	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
552536002662	dimerization interface [polypeptide binding]; other site
552536002663	putative ATP binding site [chemical binding]; other site
552536002664	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
552536002665	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
552536002666	active site
552536002667	substrate binding site [chemical binding]; other site
552536002668	cosubstrate binding site; other site
552536002669	catalytic site [active]
552536002670	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
552536002671	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
552536002672	purine monophosphate binding site [chemical binding]; other site
552536002673	dimer interface [polypeptide binding]; other site
552536002674	putative catalytic residues [active]
552536002675	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
552536002676	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
552536002677	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
552536002678	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
552536002679	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
552536002680	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
552536002681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
552536002682	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
552536002683	Na2 binding site [ion binding]; other site
552536002684	putative substrate binding site 1 [chemical binding]; other site
552536002685	Na binding site 1 [ion binding]; other site
552536002686	putative substrate binding site 2 [chemical binding]; other site
552536002687	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
552536002688	PcrB family; Region: PcrB; pfam01884
552536002689	substrate binding site [chemical binding]; other site
552536002690	putative active site [active]
552536002691	dimer interface [polypeptide binding]; other site
552536002692	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
552536002693	Part of AAA domain; Region: AAA_19; pfam13245
552536002694	Family description; Region: UvrD_C_2; pfam13538
552536002695	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
552536002696	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
552536002697	nucleotide binding pocket [chemical binding]; other site
552536002698	K-X-D-G motif; other site
552536002699	catalytic site [active]
552536002700	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
552536002701	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
552536002702	Dimer interface [polypeptide binding]; other site
552536002703	BRCT sequence motif; other site
552536002704	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
552536002705	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
552536002706	putative dimer interface [polypeptide binding]; other site
552536002707	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
552536002708	putative dimer interface [polypeptide binding]; other site
552536002709	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
552536002710	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
552536002711	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
552536002712	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
552536002713	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
552536002714	GatB domain; Region: GatB_Yqey; pfam02637
552536002715	putative lipid kinase; Reviewed; Region: PRK13337
552536002716	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
552536002717	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
552536002718	TRAM domain; Region: TRAM; pfam01938
552536002719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536002720	S-adenosylmethionine binding site [chemical binding]; other site
552536002721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
552536002722	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
552536002723	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
552536002724	ADP binding site [chemical binding]; other site
552536002725	magnesium binding site [ion binding]; other site
552536002726	putative shikimate binding site; other site
552536002727	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536002728	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536002729	Walker A/P-loop; other site
552536002730	ATP binding site [chemical binding]; other site
552536002731	Q-loop/lid; other site
552536002732	ABC transporter signature motif; other site
552536002733	Walker B; other site
552536002734	D-loop; other site
552536002735	H-loop/switch region; other site
552536002736	FtsX-like permease family; Region: FtsX; pfam02687
552536002737	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552536002738	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536002739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536002740	active site
552536002741	phosphorylation site [posttranslational modification]
552536002742	intermolecular recognition site; other site
552536002743	dimerization interface [polypeptide binding]; other site
552536002744	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536002745	DNA binding site [nucleotide binding]
552536002746	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
552536002747	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
552536002748	putative NAD(P) binding site [chemical binding]; other site
552536002749	active site
552536002750	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
552536002751	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
552536002752	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
552536002753	active site
552536002754	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
552536002755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
552536002756	dimer interface [polypeptide binding]; other site
552536002757	phosphorylation site [posttranslational modification]
552536002758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536002759	ATP binding site [chemical binding]; other site
552536002760	Mg2+ binding site [ion binding]; other site
552536002761	G-X-G motif; other site
552536002762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536002763	dimer interface [polypeptide binding]; other site
552536002764	conserved gate region; other site
552536002765	putative PBP binding loops; other site
552536002766	ABC-ATPase subunit interface; other site
552536002767	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536002768	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536002769	Walker A/P-loop; other site
552536002770	ATP binding site [chemical binding]; other site
552536002771	Q-loop/lid; other site
552536002772	ABC transporter signature motif; other site
552536002773	Walker B; other site
552536002774	D-loop; other site
552536002775	H-loop/switch region; other site
552536002776	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552536002777	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552536002778	substrate binding pocket [chemical binding]; other site
552536002779	membrane-bound complex binding site; other site
552536002780	hinge residues; other site
552536002781	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
552536002782	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
552536002783	putative active site [active]
552536002784	metal binding site [ion binding]; metal-binding site
552536002785	Predicted acetyltransferase [General function prediction only]; Region: COG3153
552536002786	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536002787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536002788	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
552536002789	putative dimerization interface [polypeptide binding]; other site
552536002790	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
552536002791	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
552536002792	active site
552536002793	dimer interface [polypeptide binding]; other site
552536002794	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
552536002795	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
552536002796	active site
552536002797	FMN binding site [chemical binding]; other site
552536002798	substrate binding site [chemical binding]; other site
552536002799	3Fe-4S cluster binding site [ion binding]; other site
552536002800	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
552536002801	domain interface; other site
552536002802	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
552536002803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552536002804	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536002805	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536002806	dimer interface [polypeptide binding]; other site
552536002807	conserved gate region; other site
552536002808	putative PBP binding loops; other site
552536002809	ABC-ATPase subunit interface; other site
552536002810	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536002811	dimer interface [polypeptide binding]; other site
552536002812	conserved gate region; other site
552536002813	putative PBP binding loops; other site
552536002814	ABC-ATPase subunit interface; other site
552536002815	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
552536002816	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536002817	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
552536002818	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
552536002819	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
552536002820	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
552536002821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536002822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536002823	DNA binding site [nucleotide binding]
552536002824	domain linker motif; other site
552536002825	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552536002826	dimerization interface [polypeptide binding]; other site
552536002827	ligand binding site [chemical binding]; other site
552536002828	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536002829	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536002830	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
552536002831	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536002832	ATP binding site [chemical binding]; other site
552536002833	putative Mg++ binding site [ion binding]; other site
552536002834	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536002835	nucleotide binding region [chemical binding]; other site
552536002836	ATP-binding site [chemical binding]; other site
552536002837	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
552536002838	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
552536002839	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536002840	Walker A motif; other site
552536002841	ATP binding site [chemical binding]; other site
552536002842	Walker B motif; other site
552536002843	arginine finger; other site
552536002844	Transcriptional antiterminator [Transcription]; Region: COG3933
552536002845	PRD domain; Region: PRD; pfam00874
552536002846	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536002847	active pocket/dimerization site; other site
552536002848	active site
552536002849	phosphorylation site [posttranslational modification]
552536002850	PRD domain; Region: PRD; pfam00874
552536002851	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536002852	active site
552536002853	P-loop; other site
552536002854	phosphorylation site [posttranslational modification]
552536002855	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536002856	methionine cluster; other site
552536002857	active site
552536002858	phosphorylation site [posttranslational modification]
552536002859	metal binding site [ion binding]; metal-binding site
552536002860	Uncharacterized conserved protein [Function unknown]; Region: COG3589
552536002861	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
552536002862	Uncharacterized conserved protein [Function unknown]; Region: COG4748
552536002863	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
552536002864	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536002865	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536002866	Methyltransferase domain; Region: Methyltransf_31; pfam13847
552536002867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536002868	S-adenosylmethionine binding site [chemical binding]; other site
552536002869	rod-share determining protein MreBH; Provisional; Region: PRK13929
552536002870	MreB and similar proteins; Region: MreB_like; cd10225
552536002871	nucleotide binding site [chemical binding]; other site
552536002872	Mg binding site [ion binding]; other site
552536002873	putative protofilament interaction site [polypeptide binding]; other site
552536002874	RodZ interaction site [polypeptide binding]; other site
552536002875	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536002876	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536002877	putative substrate translocation pore; other site
552536002878	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
552536002879	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
552536002880	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
552536002881	flavodoxin, short chain; Region: flav_short; TIGR01753
552536002882	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
552536002883	active site
552536002884	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
552536002885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
552536002886	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
552536002887	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
552536002888	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
552536002889	Substrate-binding site [chemical binding]; other site
552536002890	Substrate specificity [chemical binding]; other site
552536002891	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
552536002892	TRAM domain; Region: TRAM; cl01282
552536002893	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
552536002894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536002895	S-adenosylmethionine binding site [chemical binding]; other site
552536002896	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
552536002897	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
552536002898	dimer interface [polypeptide binding]; other site
552536002899	active site
552536002900	Mn binding site [ion binding]; other site
552536002901	PAS fold; Region: PAS_4; pfam08448
552536002902	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
552536002903	putative active site [active]
552536002904	heme pocket [chemical binding]; other site
552536002905	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
552536002906	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
552536002907	dimer interface [polypeptide binding]; other site
552536002908	putative CheW interface [polypeptide binding]; other site
552536002909	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
552536002910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
552536002911	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
552536002912	Cation efflux family; Region: Cation_efflux; pfam01545
552536002913	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
552536002914	Predicted integral membrane protein [Function unknown]; Region: COG0392
552536002915	Uncharacterized conserved protein [Function unknown]; Region: COG2898
552536002916	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
552536002917	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552536002918	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
552536002919	NAD(P) binding site [chemical binding]; other site
552536002920	active site
552536002921	recombination regulator RecX; Provisional; Region: recX; PRK14135
552536002922	WVELL protein; Region: WVELL; pfam14043
552536002923	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
552536002924	trimer interface [polypeptide binding]; other site
552536002925	active site
552536002926	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
552536002927	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
552536002928	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
552536002929	minor groove reading motif; other site
552536002930	helix-hairpin-helix signature motif; other site
552536002931	substrate binding pocket [chemical binding]; other site
552536002932	active site
552536002933	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
552536002934	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
552536002935	DNA binding and oxoG recognition site [nucleotide binding]
552536002936	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
552536002937	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
552536002938	putative NAD(P) binding site [chemical binding]; other site
552536002939	active site
552536002940	hypothetical protein; Provisional; Region: PRK13662
552536002941	Predicted membrane protein [Function unknown]; Region: COG4129
552536002942	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
552536002943	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
552536002944	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
552536002945	inhibitor-cofactor binding pocket; inhibition site
552536002946	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536002947	catalytic residue [active]
552536002948	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
552536002949	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
552536002950	NAD binding site [chemical binding]; other site
552536002951	ferric uptake regulator; Provisional; Region: fur; PRK09462
552536002952	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
552536002953	metal binding site 2 [ion binding]; metal-binding site
552536002954	putative DNA binding helix; other site
552536002955	metal binding site 1 [ion binding]; metal-binding site
552536002956	dimer interface [polypeptide binding]; other site
552536002957	structural Zn2+ binding site [ion binding]; other site
552536002958	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536002959	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536002960	putative substrate translocation pore; other site
552536002961	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
552536002962	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
552536002963	THF binding site; other site
552536002964	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
552536002965	substrate binding site [chemical binding]; other site
552536002966	THF binding site; other site
552536002967	zinc-binding site [ion binding]; other site
552536002968	cystathionine gamma-synthase; Reviewed; Region: PRK08247
552536002969	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552536002970	homodimer interface [polypeptide binding]; other site
552536002971	substrate-cofactor binding pocket; other site
552536002972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536002973	catalytic residue [active]
552536002974	cystathionine beta-lyase; Provisional; Region: PRK08064
552536002975	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552536002976	homodimer interface [polypeptide binding]; other site
552536002977	substrate-cofactor binding pocket; other site
552536002978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536002979	catalytic residue [active]
552536002980	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
552536002981	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
552536002982	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
552536002983	FAD binding site [chemical binding]; other site
552536002984	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
552536002985	UbiA prenyltransferase family; Region: UbiA; pfam01040
552536002986	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
552536002987	chorismate binding enzyme; Region: Chorismate_bind; cl10555
552536002988	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
552536002989	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
552536002990	dimer interface [polypeptide binding]; other site
552536002991	tetramer interface [polypeptide binding]; other site
552536002992	PYR/PP interface [polypeptide binding]; other site
552536002993	TPP binding site [chemical binding]; other site
552536002994	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
552536002995	TPP-binding site; other site
552536002996	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
552536002997	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
552536002998	TAP-like protein; Region: Abhydrolase_4; pfam08386
552536002999	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
552536003000	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
552536003001	substrate binding site [chemical binding]; other site
552536003002	oxyanion hole (OAH) forming residues; other site
552536003003	trimer interface [polypeptide binding]; other site
552536003004	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
552536003005	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
552536003006	acyl-activating enzyme (AAE) consensus motif; other site
552536003007	putative AMP binding site [chemical binding]; other site
552536003008	putative active site [active]
552536003009	putative CoA binding site [chemical binding]; other site
552536003010	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
552536003011	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
552536003012	metal binding site [ion binding]; metal-binding site
552536003013	Uncharacterized conserved protein [Function unknown]; Region: COG0759
552536003014	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
552536003015	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
552536003016	nudix motif; other site
552536003017	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
552536003018	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
552536003019	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536003020	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
552536003021	NAD binding site [chemical binding]; other site
552536003022	dimer interface [polypeptide binding]; other site
552536003023	substrate binding site [chemical binding]; other site
552536003024	S-adenosylmethionine synthetase; Validated; Region: PRK05250
552536003025	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
552536003026	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
552536003027	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
552536003028	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
552536003029	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
552536003030	active site
552536003031	dimer interface [polypeptide binding]; other site
552536003032	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
552536003033	Ligand Binding Site [chemical binding]; other site
552536003034	Molecular Tunnel; other site
552536003035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003036	S-adenosylmethionine binding site [chemical binding]; other site
552536003037	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
552536003038	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552536003039	FeS/SAM binding site; other site
552536003040	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
552536003041	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
552536003042	HIGH motif; other site
552536003043	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
552536003044	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
552536003045	active site
552536003046	KMSKS motif; other site
552536003047	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
552536003048	tRNA binding surface [nucleotide binding]; other site
552536003049	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
552536003050	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
552536003051	rRNA interaction site [nucleotide binding]; other site
552536003052	S8 interaction site; other site
552536003053	putative laminin-1 binding site; other site
552536003054	elongation factor Ts; Provisional; Region: tsf; PRK09377
552536003055	UBA/TS-N domain; Region: UBA; pfam00627
552536003056	Elongation factor TS; Region: EF_TS; pfam00889
552536003057	Elongation factor TS; Region: EF_TS; pfam00889
552536003058	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
552536003059	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
552536003060	active site
552536003061	active site
552536003062	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536003063	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
552536003064	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536003065	Walker A/P-loop; other site
552536003066	ATP binding site [chemical binding]; other site
552536003067	Q-loop/lid; other site
552536003068	ABC transporter signature motif; other site
552536003069	Walker B; other site
552536003070	D-loop; other site
552536003071	H-loop/switch region; other site
552536003072	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536003073	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536003074	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
552536003075	Walker A/P-loop; other site
552536003076	ATP binding site [chemical binding]; other site
552536003077	Q-loop/lid; other site
552536003078	ABC transporter signature motif; other site
552536003079	Walker B; other site
552536003080	D-loop; other site
552536003081	H-loop/switch region; other site
552536003082	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
552536003083	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
552536003084	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
552536003085	putative acyl-acceptor binding pocket; other site
552536003086	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
552536003087	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
552536003088	active site
552536003089	metal binding site [ion binding]; metal-binding site
552536003090	DNA binding site [nucleotide binding]
552536003091	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
552536003092	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
552536003093	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
552536003094	Walker A/P-loop; other site
552536003095	ATP binding site [chemical binding]; other site
552536003096	Q-loop/lid; other site
552536003097	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
552536003098	ABC transporter signature motif; other site
552536003099	Walker B; other site
552536003100	D-loop; other site
552536003101	H-loop/switch region; other site
552536003102	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
552536003103	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
552536003104	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536003105	ATP binding site [chemical binding]; other site
552536003106	putative Mg++ binding site [ion binding]; other site
552536003107	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536003108	nucleotide binding region [chemical binding]; other site
552536003109	ATP-binding site [chemical binding]; other site
552536003110	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536003111	aconitate hydratase; Validated; Region: PRK09277
552536003112	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
552536003113	substrate binding site [chemical binding]; other site
552536003114	ligand binding site [chemical binding]; other site
552536003115	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
552536003116	substrate binding site [chemical binding]; other site
552536003117	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
552536003118	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
552536003119	putative dimer interface [polypeptide binding]; other site
552536003120	catalytic triad [active]
552536003121	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552536003122	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
552536003123	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536003124	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536003125	Walker A/P-loop; other site
552536003126	ATP binding site [chemical binding]; other site
552536003127	Q-loop/lid; other site
552536003128	ABC transporter signature motif; other site
552536003129	Walker B; other site
552536003130	D-loop; other site
552536003131	H-loop/switch region; other site
552536003132	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
552536003133	dimer interface [polypeptide binding]; other site
552536003134	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
552536003135	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
552536003136	putative catalytic cysteine [active]
552536003137	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
552536003138	putative active site [active]
552536003139	metal binding site [ion binding]; metal-binding site
552536003140	anthranilate synthase component I; Provisional; Region: PRK13570
552536003141	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
552536003142	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
552536003143	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
552536003144	Glutamine amidotransferase class-I; Region: GATase; pfam00117
552536003145	glutamine binding [chemical binding]; other site
552536003146	catalytic triad [active]
552536003147	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
552536003148	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
552536003149	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
552536003150	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
552536003151	active site
552536003152	ribulose/triose binding site [chemical binding]; other site
552536003153	phosphate binding site [ion binding]; other site
552536003154	substrate (anthranilate) binding pocket [chemical binding]; other site
552536003155	product (indole) binding pocket [chemical binding]; other site
552536003156	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
552536003157	active site
552536003158	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
552536003159	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
552536003160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536003161	catalytic residue [active]
552536003162	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
552536003163	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
552536003164	substrate binding site [chemical binding]; other site
552536003165	active site
552536003166	catalytic residues [active]
552536003167	heterodimer interface [polypeptide binding]; other site
552536003168	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
552536003169	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
552536003170	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
552536003171	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
552536003172	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
552536003173	active site
552536003174	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
552536003175	putative substrate binding site [chemical binding]; other site
552536003176	putative ATP binding site [chemical binding]; other site
552536003177	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
552536003178	nudix motif; other site
552536003179	dipeptidase PepV; Reviewed; Region: PRK07318
552536003180	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
552536003181	active site
552536003182	metal binding site [ion binding]; metal-binding site
552536003183	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
552536003184	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
552536003185	homodimer interface [polypeptide binding]; other site
552536003186	substrate-cofactor binding pocket; other site
552536003187	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536003188	catalytic residue [active]
552536003189	MarR family; Region: MarR; pfam01047
552536003190	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
552536003191	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536003192	putative substrate translocation pore; other site
552536003193	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536003194	Phosphotransferase enzyme family; Region: APH; pfam01636
552536003195	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
552536003196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003197	S-adenosylmethionine binding site [chemical binding]; other site
552536003198	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536003199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
552536003200	putative homodimer interface [polypeptide binding]; other site
552536003201	putative homotetramer interface [polypeptide binding]; other site
552536003202	putative allosteric switch controlling residues; other site
552536003203	putative metal binding site [ion binding]; other site
552536003204	putative homodimer-homodimer interface [polypeptide binding]; other site
552536003205	Predicted small secreted protein [Function unknown]; Region: COG5584
552536003206	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
552536003207	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
552536003208	oligomer interface [polypeptide binding]; other site
552536003209	active site
552536003210	metal binding site [ion binding]; metal-binding site
552536003211	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
552536003212	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536003213	catalytic residues [active]
552536003214	hypothetical protein; Provisional; Region: PRK13668
552536003215	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
552536003216	putative tRNA-binding site [nucleotide binding]; other site
552536003217	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
552536003218	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552536003219	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
552536003220	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
552536003221	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552536003222	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552536003223	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552536003224	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
552536003225	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
552536003226	dimer interface [polypeptide binding]; other site
552536003227	decamer (pentamer of dimers) interface [polypeptide binding]; other site
552536003228	catalytic triad [active]
552536003229	peroxidatic and resolving cysteines [active]
552536003230	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
552536003231	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
552536003232	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
552536003233	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
552536003234	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
552536003235	Chorismate mutase type II; Region: CM_2; cl00693
552536003236	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
552536003237	catabolite control protein A; Region: ccpA; TIGR01481
552536003238	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536003239	DNA binding site [nucleotide binding]
552536003240	domain linker motif; other site
552536003241	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
552536003242	dimerization interface [polypeptide binding]; other site
552536003243	effector binding site; other site
552536003244	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
552536003245	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
552536003246	active site
552536003247	HIGH motif; other site
552536003248	dimer interface [polypeptide binding]; other site
552536003249	KMSKS motif; other site
552536003250	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536003251	RNA binding surface [nucleotide binding]; other site
552536003252	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
552536003253	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
552536003254	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536003255	RNA binding surface [nucleotide binding]; other site
552536003256	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
552536003257	GAF domain; Region: GAF_2; pfam13185
552536003258	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
552536003259	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
552536003260	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
552536003261	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536003262	catalytic residue [active]
552536003263	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
552536003264	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
552536003265	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
552536003266	Ligand Binding Site [chemical binding]; other site
552536003267	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
552536003268	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
552536003269	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
552536003270	heterotetramer interface [polypeptide binding]; other site
552536003271	active site pocket [active]
552536003272	cleavage site
552536003273	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
552536003274	nucleotide binding site [chemical binding]; other site
552536003275	N-acetyl-L-glutamate binding site [chemical binding]; other site
552536003276	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
552536003277	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
552536003278	inhibitor-cofactor binding pocket; inhibition site
552536003279	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536003280	catalytic residue [active]
552536003281	ornithine carbamoyltransferase; Provisional; Region: PRK00779
552536003282	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
552536003283	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
552536003284	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
552536003285	ATP-NAD kinase; Region: NAD_kinase; pfam01513
552536003286	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
552536003287	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
552536003288	tandem repeat interface [polypeptide binding]; other site
552536003289	oligomer interface [polypeptide binding]; other site
552536003290	active site residues [active]
552536003291	RDD family; Region: RDD; pfam06271
552536003292	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
552536003293	dimer interface [polypeptide binding]; other site
552536003294	catalytic triad [active]
552536003295	peroxidatic and resolving cysteines [active]
552536003296	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
552536003297	Domain of unknown function (DUF4368); Region: DUF4368; pfam14287
552536003298	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
552536003299	Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770
552536003300	putative catalytic residues [active]
552536003301	catalytic nucleophile [active]
552536003302	Recombinase; Region: Recombinase; pfam07508
552536003303	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536003304	DNA binding residues [nucleotide binding]
552536003305	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536003306	putative dimer interface [polypeptide binding]; other site
552536003307	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
552536003308	classical (c) SDRs; Region: SDR_c; cd05233
552536003309	NAD(P) binding site [chemical binding]; other site
552536003310	active site
552536003311	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
552536003312	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552536003313	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
552536003314	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003315	S-adenosylmethionine binding site [chemical binding]; other site
552536003316	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
552536003317	propionate/acetate kinase; Provisional; Region: PRK12379
552536003318	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552536003319	Ligand Binding Site [chemical binding]; other site
552536003320	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
552536003321	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
552536003322	hexamer interface [polypeptide binding]; other site
552536003323	ligand binding site [chemical binding]; other site
552536003324	putative active site [active]
552536003325	NAD(P) binding site [chemical binding]; other site
552536003326	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
552536003327	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
552536003328	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
552536003329	active site
552536003330	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
552536003331	metal-dependent hydrolase; Provisional; Region: PRK00685
552536003332	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
552536003333	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
552536003334	DNA-binding site [nucleotide binding]; DNA binding site
552536003335	DRTGG domain; Region: DRTGG; pfam07085
552536003336	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
552536003337	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
552536003338	active site 2 [active]
552536003339	active site 1 [active]
552536003340	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
552536003341	DHH family; Region: DHH; pfam01368
552536003342	DHHA1 domain; Region: DHHA1; pfam02272
552536003343	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
552536003344	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
552536003345	active site
552536003346	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
552536003347	generic binding surface I; other site
552536003348	generic binding surface II; other site
552536003349	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
552536003350	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
552536003351	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
552536003352	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
552536003353	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
552536003354	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
552536003355	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
552536003356	active site
552536003357	ADP/pyrophosphate binding site [chemical binding]; other site
552536003358	dimerization interface [polypeptide binding]; other site
552536003359	allosteric effector site; other site
552536003360	fructose-1,6-bisphosphate binding site; other site
552536003361	pyruvate kinase; Provisional; Region: PRK06354
552536003362	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
552536003363	domain interfaces; other site
552536003364	active site
552536003365	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
552536003366	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
552536003367	Protein of unknown function (DUF441); Region: DUF441; pfam04284
552536003368	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
552536003369	dimer interface [polypeptide binding]; other site
552536003370	Citrate synthase; Region: Citrate_synt; pfam00285
552536003371	active site
552536003372	citrylCoA binding site [chemical binding]; other site
552536003373	oxalacetate/citrate binding site [chemical binding]; other site
552536003374	coenzyme A binding site [chemical binding]; other site
552536003375	catalytic triad [active]
552536003376	isocitrate dehydrogenase; Reviewed; Region: PRK07006
552536003377	isocitrate dehydrogenase; Validated; Region: PRK07362
552536003378	DNA polymerase I; Provisional; Region: PRK05755
552536003379	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
552536003380	active site
552536003381	metal binding site 1 [ion binding]; metal-binding site
552536003382	putative 5' ssDNA interaction site; other site
552536003383	metal binding site 3; metal-binding site
552536003384	metal binding site 2 [ion binding]; metal-binding site
552536003385	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
552536003386	putative DNA binding site [nucleotide binding]; other site
552536003387	putative metal binding site [ion binding]; other site
552536003388	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
552536003389	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
552536003390	active site
552536003391	DNA binding site [nucleotide binding]
552536003392	catalytic site [active]
552536003393	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
552536003394	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
552536003395	DNA binding site [nucleotide binding]
552536003396	catalytic residue [active]
552536003397	H2TH interface [polypeptide binding]; other site
552536003398	putative catalytic residues [active]
552536003399	turnover-facilitating residue; other site
552536003400	intercalation triad [nucleotide binding]; other site
552536003401	8OG recognition residue [nucleotide binding]; other site
552536003402	putative reading head residues; other site
552536003403	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
552536003404	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
552536003405	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
552536003406	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
552536003407	CoA-binding site [chemical binding]; other site
552536003408	ATP-binding [chemical binding]; other site
552536003409	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
552536003410	ATP cone domain; Region: ATP-cone; pfam03477
552536003411	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
552536003412	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
552536003413	primosomal protein DnaI; Reviewed; Region: PRK08939
552536003414	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
552536003415	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
552536003416	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
552536003417	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
552536003418	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
552536003419	active site
552536003420	dimer interface [polypeptide binding]; other site
552536003421	motif 1; other site
552536003422	motif 2; other site
552536003423	motif 3; other site
552536003424	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
552536003425	anticodon binding site; other site
552536003426	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
552536003427	G1 box; other site
552536003428	GTP/Mg2+ binding site [chemical binding]; other site
552536003429	Switch I region; other site
552536003430	G2 box; other site
552536003431	G3 box; other site
552536003432	Switch II region; other site
552536003433	G4 box; other site
552536003434	G5 box; other site
552536003435	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
552536003436	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
552536003437	tRNA; other site
552536003438	putative tRNA binding site [nucleotide binding]; other site
552536003439	putative NADP binding site [chemical binding]; other site
552536003440	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
552536003441	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
552536003442	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
552536003443	domain interfaces; other site
552536003444	active site
552536003445	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
552536003446	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
552536003447	active site
552536003448	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
552536003449	dimer interface [polypeptide binding]; other site
552536003450	active site
552536003451	Schiff base residues; other site
552536003452	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
552536003453	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
552536003454	inhibitor-cofactor binding pocket; inhibition site
552536003455	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536003456	catalytic residue [active]
552536003457	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
552536003458	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552536003459	active site
552536003460	HIGH motif; other site
552536003461	nucleotide binding site [chemical binding]; other site
552536003462	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
552536003463	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
552536003464	active site
552536003465	KMSKS motif; other site
552536003466	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
552536003467	tRNA binding surface [nucleotide binding]; other site
552536003468	anticodon binding site; other site
552536003469	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
552536003470	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
552536003471	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552536003472	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552536003473	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
552536003474	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
552536003475	hypothetical protein; Reviewed; Region: PRK00024
552536003476	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
552536003477	MPN+ (JAMM) motif; other site
552536003478	Zinc-binding site [ion binding]; other site
552536003479	rod shape-determining protein MreB; Provisional; Region: PRK13927
552536003480	MreB and similar proteins; Region: MreB_like; cd10225
552536003481	nucleotide binding site [chemical binding]; other site
552536003482	Mg binding site [ion binding]; other site
552536003483	putative protofilament interaction site [polypeptide binding]; other site
552536003484	RodZ interaction site [polypeptide binding]; other site
552536003485	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
552536003486	Protein of unknown function (DUF972); Region: DUF972; pfam06156
552536003487	rod shape-determining protein MreC; Region: MreC; pfam04085
552536003488	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
552536003489	septum formation inhibitor; Reviewed; Region: minC; PRK00513
552536003490	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
552536003491	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
552536003492	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
552536003493	Switch I; other site
552536003494	Switch II; other site
552536003495	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
552536003496	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
552536003497	homodimer interface [polypeptide binding]; other site
552536003498	oligonucleotide binding site [chemical binding]; other site
552536003499	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
552536003500	hypothetical protein; Provisional; Region: PRK14553
552536003501	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
552536003502	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
552536003503	amphipathic channel; other site
552536003504	Asn-Pro-Ala signature motifs; other site
552536003505	glycerol kinase; Provisional; Region: glpK; PRK00047
552536003506	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
552536003507	N- and C-terminal domain interface [polypeptide binding]; other site
552536003508	active site
552536003509	MgATP binding site [chemical binding]; other site
552536003510	catalytic site [active]
552536003511	metal binding site [ion binding]; metal-binding site
552536003512	glycerol binding site [chemical binding]; other site
552536003513	homotetramer interface [polypeptide binding]; other site
552536003514	homodimer interface [polypeptide binding]; other site
552536003515	FBP binding site [chemical binding]; other site
552536003516	protein IIAGlc interface [polypeptide binding]; other site
552536003517	GTPase CgtA; Reviewed; Region: obgE; PRK12297
552536003518	GTP1/OBG; Region: GTP1_OBG; pfam01018
552536003519	Obg GTPase; Region: Obg; cd01898
552536003520	G1 box; other site
552536003521	GTP/Mg2+ binding site [chemical binding]; other site
552536003522	Switch I region; other site
552536003523	G2 box; other site
552536003524	G3 box; other site
552536003525	Switch II region; other site
552536003526	G4 box; other site
552536003527	G5 box; other site
552536003528	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
552536003529	prephenate dehydratase; Provisional; Region: PRK11898
552536003530	Prephenate dehydratase; Region: PDT; pfam00800
552536003531	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
552536003532	putative L-Phe binding site [chemical binding]; other site
552536003533	hypothetical protein; Validated; Region: PRK00110
552536003534	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
552536003535	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536003536	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
552536003537	NAD binding site [chemical binding]; other site
552536003538	dimer interface [polypeptide binding]; other site
552536003539	substrate binding site [chemical binding]; other site
552536003540	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
552536003541	RuvA N terminal domain; Region: RuvA_N; pfam01330
552536003542	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
552536003543	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
552536003544	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536003545	Walker A motif; other site
552536003546	ATP binding site [chemical binding]; other site
552536003547	Walker B motif; other site
552536003548	arginine finger; other site
552536003549	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
552536003550	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
552536003551	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
552536003552	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
552536003553	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
552536003554	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
552536003555	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
552536003556	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
552536003557	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
552536003558	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
552536003559	Protein export membrane protein; Region: SecD_SecF; pfam02355
552536003560	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
552536003561	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
552536003562	DHH family; Region: DHH; pfam01368
552536003563	DHHA1 domain; Region: DHHA1; pfam02272
552536003564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
552536003565	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536003566	active site
552536003567	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
552536003568	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536003569	Zn2+ binding site [ion binding]; other site
552536003570	Mg2+ binding site [ion binding]; other site
552536003571	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
552536003572	synthetase active site [active]
552536003573	NTP binding site [chemical binding]; other site
552536003574	metal binding site [ion binding]; metal-binding site
552536003575	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
552536003576	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
552536003577	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
552536003578	putative active site [active]
552536003579	dimerization interface [polypeptide binding]; other site
552536003580	putative tRNAtyr binding site [nucleotide binding]; other site
552536003581	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
552536003582	Bacterial SH3 domain; Region: SH3_3; pfam08239
552536003583	Bacterial SH3 domain; Region: SH3_3; pfam08239
552536003584	Bacterial SH3 domain homologues; Region: SH3b; smart00287
552536003585	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
552536003586	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
552536003587	active site
552536003588	metal binding site [ion binding]; metal-binding site
552536003589	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
552536003590	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
552536003591	dimer interface [polypeptide binding]; other site
552536003592	motif 1; other site
552536003593	active site
552536003594	motif 2; other site
552536003595	motif 3; other site
552536003596	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
552536003597	anticodon binding site; other site
552536003598	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
552536003599	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
552536003600	dimer interface [polypeptide binding]; other site
552536003601	anticodon binding site; other site
552536003602	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
552536003603	homodimer interface [polypeptide binding]; other site
552536003604	motif 1; other site
552536003605	active site
552536003606	motif 2; other site
552536003607	GAD domain; Region: GAD; pfam02938
552536003608	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
552536003609	motif 3; other site
552536003610	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
552536003611	Nitrogen regulatory protein P-II; Region: P-II; smart00938
552536003612	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
552536003613	Predicted transcriptional regulator [Transcription]; Region: COG1959
552536003614	Transcriptional regulator; Region: Rrf2; pfam02082
552536003615	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
552536003616	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536003617	Walker A motif; other site
552536003618	ATP binding site [chemical binding]; other site
552536003619	Walker B motif; other site
552536003620	arginine finger; other site
552536003621	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
552536003622	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
552536003623	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
552536003624	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536003625	catalytic residue [active]
552536003626	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
552536003627	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
552536003628	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
552536003629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536003630	binding surface
552536003631	TPR motif; other site
552536003632	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
552536003633	TPR repeat; Region: TPR_11; pfam13414
552536003634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536003635	binding surface
552536003636	TPR motif; other site
552536003637	TPR repeat; Region: TPR_11; pfam13414
552536003638	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
552536003639	AAA domain; Region: AAA_30; pfam13604
552536003640	Family description; Region: UvrD_C_2; pfam13538
552536003641	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
552536003642	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536003643	dimerization interface [polypeptide binding]; other site
552536003644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536003645	dimer interface [polypeptide binding]; other site
552536003646	phosphorylation site [posttranslational modification]
552536003647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536003648	ATP binding site [chemical binding]; other site
552536003649	Mg2+ binding site [ion binding]; other site
552536003650	G-X-G motif; other site
552536003651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536003652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536003653	active site
552536003654	phosphorylation site [posttranslational modification]
552536003655	intermolecular recognition site; other site
552536003656	dimerization interface [polypeptide binding]; other site
552536003657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536003658	DNA binding site [nucleotide binding]
552536003659	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536003660	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552536003661	FtsX-like permease family; Region: FtsX; pfam02687
552536003662	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536003663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536003664	Walker A/P-loop; other site
552536003665	ATP binding site [chemical binding]; other site
552536003666	Q-loop/lid; other site
552536003667	ABC transporter signature motif; other site
552536003668	Walker B; other site
552536003669	D-loop; other site
552536003670	H-loop/switch region; other site
552536003671	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
552536003672	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
552536003673	motif 1; other site
552536003674	active site
552536003675	motif 2; other site
552536003676	motif 3; other site
552536003677	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
552536003678	DHHA1 domain; Region: DHHA1; pfam02272
552536003679	hypothetical protein; Provisional; Region: PRK05473
552536003680	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
552536003681	hypothetical protein; Provisional; Region: PRK13678
552536003682	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
552536003683	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
552536003684	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
552536003685	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
552536003686	dimerization interface [polypeptide binding]; other site
552536003687	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
552536003688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003689	S-adenosylmethionine binding site [chemical binding]; other site
552536003690	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
552536003691	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
552536003692	Sugar specificity; other site
552536003693	Pyrimidine base specificity; other site
552536003694	ATP-binding site [chemical binding]; other site
552536003695	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
552536003696	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
552536003697	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
552536003698	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
552536003699	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
552536003700	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
552536003701	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
552536003702	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
552536003703	active site
552536003704	Zn binding site [ion binding]; other site
552536003705	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
552536003706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536003707	motif II; other site
552536003708	GTPase YqeH; Provisional; Region: PRK13796
552536003709	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
552536003710	GTP/Mg2+ binding site [chemical binding]; other site
552536003711	G4 box; other site
552536003712	G5 box; other site
552536003713	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
552536003714	G1 box; other site
552536003715	G1 box; other site
552536003716	GTP/Mg2+ binding site [chemical binding]; other site
552536003717	G2 box; other site
552536003718	Switch I region; other site
552536003719	G2 box; other site
552536003720	Switch I region; other site
552536003721	G3 box; other site
552536003722	G3 box; other site
552536003723	Switch II region; other site
552536003724	Switch II region; other site
552536003725	G4 box; other site
552536003726	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
552536003727	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
552536003728	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
552536003729	shikimate binding site; other site
552536003730	NAD(P) binding site [chemical binding]; other site
552536003731	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
552536003732	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
552536003733	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
552536003734	active site
552536003735	(T/H)XGH motif; other site
552536003736	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536003737	Zn2+ binding site [ion binding]; other site
552536003738	Mg2+ binding site [ion binding]; other site
552536003739	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
552536003740	Methyltransferase domain; Region: Methyltransf_23; pfam13489
552536003741	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003742	S-adenosylmethionine binding site [chemical binding]; other site
552536003743	SLBB domain; Region: SLBB; pfam10531
552536003744	comEA protein; Region: comE; TIGR01259
552536003745	Helix-hairpin-helix motif; Region: HHH; pfam00633
552536003746	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
552536003747	DNA binding site [nucleotide binding]
552536003748	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
552536003749	catalytic motif [active]
552536003750	Zn binding site [ion binding]; other site
552536003751	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
552536003752	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
552536003753	Competence protein; Region: Competence; pfam03772
552536003754	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536003755	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
552536003756	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
552536003757	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
552536003758	GTP-binding protein LepA; Provisional; Region: PRK05433
552536003759	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
552536003760	G1 box; other site
552536003761	putative GEF interaction site [polypeptide binding]; other site
552536003762	GTP/Mg2+ binding site [chemical binding]; other site
552536003763	Switch I region; other site
552536003764	G2 box; other site
552536003765	G3 box; other site
552536003766	Switch II region; other site
552536003767	G4 box; other site
552536003768	G5 box; other site
552536003769	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
552536003770	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
552536003771	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
552536003772	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536003773	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536003774	DNA binding residues [nucleotide binding]
552536003775	putative dimer interface [polypeptide binding]; other site
552536003776	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
552536003777	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
552536003778	NADP binding site [chemical binding]; other site
552536003779	putative substrate binding site [chemical binding]; other site
552536003780	active site
552536003781	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
552536003782	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552536003783	FeS/SAM binding site; other site
552536003784	HemN C-terminal domain; Region: HemN_C; pfam06969
552536003785	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
552536003786	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
552536003787	heat shock protein GrpE; Provisional; Region: PRK14140
552536003788	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
552536003789	dimer interface [polypeptide binding]; other site
552536003790	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
552536003791	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
552536003792	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
552536003793	nucleotide binding site [chemical binding]; other site
552536003794	NEF interaction site [polypeptide binding]; other site
552536003795	SBD interface [polypeptide binding]; other site
552536003796	chaperone protein DnaJ; Provisional; Region: PRK14280
552536003797	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
552536003798	HSP70 interaction site [polypeptide binding]; other site
552536003799	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
552536003800	substrate binding site [polypeptide binding]; other site
552536003801	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
552536003802	Zn binding sites [ion binding]; other site
552536003803	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
552536003804	dimer interface [polypeptide binding]; other site
552536003805	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
552536003806	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536003807	S-adenosylmethionine binding site [chemical binding]; other site
552536003808	RNA methyltransferase, RsmE family; Region: TIGR00046
552536003809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
552536003810	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
552536003811	Yqey-like protein; Region: YqeY; pfam09424
552536003812	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
552536003813	PhoH-like protein; Region: PhoH; pfam02562
552536003814	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
552536003815	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
552536003816	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536003817	Zn2+ binding site [ion binding]; other site
552536003818	Mg2+ binding site [ion binding]; other site
552536003819	metal-binding heat shock protein; Provisional; Region: PRK00016
552536003820	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
552536003821	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
552536003822	active site
552536003823	catalytic motif [active]
552536003824	Zn binding site [ion binding]; other site
552536003825	GTPase Era; Reviewed; Region: era; PRK00089
552536003826	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
552536003827	G1 box; other site
552536003828	GTP/Mg2+ binding site [chemical binding]; other site
552536003829	Switch I region; other site
552536003830	G2 box; other site
552536003831	Switch II region; other site
552536003832	G3 box; other site
552536003833	G4 box; other site
552536003834	G5 box; other site
552536003835	KH domain; Region: KH_2; pfam07650
552536003836	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
552536003837	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
552536003838	Recombination protein O N terminal; Region: RecO_N; pfam11967
552536003839	Recombination protein O C terminal; Region: RecO_C; pfam02565
552536003840	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
552536003841	dimer interface [polypeptide binding]; other site
552536003842	motif 1; other site
552536003843	active site
552536003844	motif 2; other site
552536003845	motif 3; other site
552536003846	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
552536003847	DALR anticodon binding domain; Region: DALR_1; pfam05746
552536003848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
552536003849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
552536003850	DNA primase; Validated; Region: dnaG; PRK05667
552536003851	CHC2 zinc finger; Region: zf-CHC2; pfam01807
552536003852	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
552536003853	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
552536003854	active site
552536003855	metal binding site [ion binding]; metal-binding site
552536003856	interdomain interaction site; other site
552536003857	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
552536003858	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
552536003859	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
552536003860	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
552536003861	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552536003862	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
552536003863	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
552536003864	DNA binding residues [nucleotide binding]
552536003865	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
552536003866	Family of unknown function (DUF633); Region: DUF633; pfam04816
552536003867	Uncharacterized conserved protein [Function unknown]; Region: COG0327
552536003868	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
552536003869	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
552536003870	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
552536003871	Uncharacterized conserved protein [Function unknown]; Region: COG0327
552536003872	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
552536003873	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552536003874	ATP binding site [chemical binding]; other site
552536003875	Mg++ binding site [ion binding]; other site
552536003876	motif III; other site
552536003877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536003878	nucleotide binding region [chemical binding]; other site
552536003879	ATP-binding site [chemical binding]; other site
552536003880	endonuclease IV; Provisional; Region: PRK01060
552536003881	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
552536003882	AP (apurinic/apyrimidinic) site pocket; other site
552536003883	DNA interaction; other site
552536003884	Metal-binding active site; metal-binding site
552536003885	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
552536003886	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
552536003887	DHHA2 domain; Region: DHHA2; pfam02833
552536003888	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552536003889	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
552536003890	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
552536003891	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552536003892	ABC-ATPase subunit  interface; other site
552536003893	dimer interface [polypeptide binding]; other site
552536003894	putative PBP binding regions; other site
552536003895	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
552536003896	metal binding site 2 [ion binding]; metal-binding site
552536003897	putative DNA binding helix; other site
552536003898	metal binding site 1 [ion binding]; metal-binding site
552536003899	dimer interface [polypeptide binding]; other site
552536003900	structural Zn2+ binding site [ion binding]; other site
552536003901	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
552536003902	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
552536003903	Predicted membrane protein [Function unknown]; Region: COG4392
552536003904	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
552536003905	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
552536003906	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
552536003907	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
552536003908	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
552536003909	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
552536003910	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
552536003911	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552536003912	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
552536003913	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
552536003914	aspartate kinase I; Reviewed; Region: PRK08210
552536003915	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
552536003916	nucleotide binding site [chemical binding]; other site
552536003917	substrate binding site [chemical binding]; other site
552536003918	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
552536003919	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
552536003920	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
552536003921	dihydrodipicolinate synthase; Region: dapA; TIGR00674
552536003922	dimer interface [polypeptide binding]; other site
552536003923	active site
552536003924	catalytic residue [active]
552536003925	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
552536003926	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536003927	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
552536003928	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
552536003929	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
552536003930	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536003931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536003932	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
552536003933	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
552536003934	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536003935	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536003936	ABC transporter; Region: ABC_tran_2; pfam12848
552536003937	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536003938	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
552536003939	Predicted membrane protein [Function unknown]; Region: COG3859
552536003940	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
552536003941	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
552536003942	Walker A/P-loop; other site
552536003943	ATP binding site [chemical binding]; other site
552536003944	Q-loop/lid; other site
552536003945	ABC transporter signature motif; other site
552536003946	Walker B; other site
552536003947	D-loop; other site
552536003948	H-loop/switch region; other site
552536003949	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
552536003950	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536003951	dimer interface [polypeptide binding]; other site
552536003952	conserved gate region; other site
552536003953	putative PBP binding loops; other site
552536003954	ABC-ATPase subunit interface; other site
552536003955	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
552536003956	LysR substrate binding domain; Region: LysR_substrate; pfam03466
552536003957	dimerization interface [polypeptide binding]; other site
552536003958	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536003959	dimer interface [polypeptide binding]; other site
552536003960	conserved gate region; other site
552536003961	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
552536003962	ABC-ATPase subunit interface; other site
552536003963	manganese transport protein MntH; Reviewed; Region: PRK00701
552536003964	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
552536003965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536003966	dimer interface [polypeptide binding]; other site
552536003967	conserved gate region; other site
552536003968	ABC-ATPase subunit interface; other site
552536003969	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
552536003970	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
552536003971	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
552536003972	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
552536003973	Walker A/P-loop; other site
552536003974	ATP binding site [chemical binding]; other site
552536003975	Q-loop/lid; other site
552536003976	ABC transporter signature motif; other site
552536003977	Walker B; other site
552536003978	D-loop; other site
552536003979	H-loop/switch region; other site
552536003980	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
552536003981	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
552536003982	FAD binding domain; Region: FAD_binding_4; pfam01565
552536003983	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
552536003984	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
552536003985	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
552536003986	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
552536003987	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
552536003988	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536003989	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
552536003990	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
552536003991	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
552536003992	dimer interface [polypeptide binding]; other site
552536003993	active site
552536003994	putative acyltransferase; Provisional; Region: PRK05790
552536003995	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
552536003996	dimer interface [polypeptide binding]; other site
552536003997	active site
552536003998	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536003999	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004000	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004001	topology modulation protein; Reviewed; Region: PRK08118
552536004002	AAA domain; Region: AAA_17; pfam13207
552536004003	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536004004	non-specific DNA binding site [nucleotide binding]; other site
552536004005	salt bridge; other site
552536004006	sequence-specific DNA binding site [nucleotide binding]; other site
552536004007	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536004008	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536004009	putative substrate translocation pore; other site
552536004010	Predicted transcriptional regulators [Transcription]; Region: COG1695
552536004011	Transcriptional regulator PadR-like family; Region: PadR; cl17335
552536004012	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
552536004013	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552536004014	FeS/SAM binding site; other site
552536004015	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
552536004016	Pyruvate formate lyase 1; Region: PFL1; cd01678
552536004017	coenzyme A binding site [chemical binding]; other site
552536004018	active site
552536004019	catalytic residues [active]
552536004020	glycine loop; other site
552536004021	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
552536004022	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
552536004023	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536004024	ATP binding site [chemical binding]; other site
552536004025	Mg2+ binding site [ion binding]; other site
552536004026	G-X-G motif; other site
552536004027	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
552536004028	ATP binding site [chemical binding]; other site
552536004029	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
552536004030	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
552536004031	MutS domain I; Region: MutS_I; pfam01624
552536004032	MutS domain II; Region: MutS_II; pfam05188
552536004033	MutS domain III; Region: MutS_III; pfam05192
552536004034	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
552536004035	Walker A/P-loop; other site
552536004036	ATP binding site [chemical binding]; other site
552536004037	Q-loop/lid; other site
552536004038	ABC transporter signature motif; other site
552536004039	Walker B; other site
552536004040	D-loop; other site
552536004041	H-loop/switch region; other site
552536004042	Predicted membrane protein [Function unknown]; Region: COG4550
552536004043	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
552536004044	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
552536004045	putative active site [active]
552536004046	metal binding site [ion binding]; metal-binding site
552536004047	homodimer binding site [polypeptide binding]; other site
552536004048	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
552536004049	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536004050	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
552536004051	Coenzyme A binding pocket [chemical binding]; other site
552536004052	phosphodiesterase; Provisional; Region: PRK12704
552536004053	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536004054	Zn2+ binding site [ion binding]; other site
552536004055	Mg2+ binding site [ion binding]; other site
552536004056	recombinase A; Provisional; Region: recA; PRK09354
552536004057	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
552536004058	hexamer interface [polypeptide binding]; other site
552536004059	Walker A motif; other site
552536004060	ATP binding site [chemical binding]; other site
552536004061	Walker B motif; other site
552536004062	competence damage-inducible protein A; Provisional; Region: PRK00549
552536004063	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
552536004064	putative MPT binding site; other site
552536004065	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
552536004066	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
552536004067	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
552536004068	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536004069	non-specific DNA binding site [nucleotide binding]; other site
552536004070	salt bridge; other site
552536004071	sequence-specific DNA binding site [nucleotide binding]; other site
552536004072	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
552536004073	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
552536004074	classical (c) SDRs; Region: SDR_c; cd05233
552536004075	NAD(P) binding site [chemical binding]; other site
552536004076	active site
552536004077	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
552536004078	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
552536004079	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
552536004080	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
552536004081	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
552536004082	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
552536004083	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
552536004084	TM-ABC transporter signature motif; other site
552536004085	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
552536004086	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
552536004087	TM-ABC transporter signature motif; other site
552536004088	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
552536004089	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
552536004090	Walker A/P-loop; other site
552536004091	ATP binding site [chemical binding]; other site
552536004092	Q-loop/lid; other site
552536004093	ABC transporter signature motif; other site
552536004094	Walker B; other site
552536004095	D-loop; other site
552536004096	H-loop/switch region; other site
552536004097	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
552536004098	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
552536004099	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
552536004100	ligand binding site [chemical binding]; other site
552536004101	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
552536004102	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
552536004103	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
552536004104	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
552536004105	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552536004106	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
552536004107	Uncharacterized conserved protein [Function unknown]; Region: COG1284
552536004108	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536004109	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536004110	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
552536004111	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
552536004112	active site residue [active]
552536004113	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
552536004114	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
552536004115	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
552536004116	homotetramer interface [polypeptide binding]; other site
552536004117	FMN binding site [chemical binding]; other site
552536004118	homodimer contacts [polypeptide binding]; other site
552536004119	putative active site [active]
552536004120	putative substrate binding site [chemical binding]; other site
552536004121	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
552536004122	acylphosphatase; Provisional; Region: PRK14443
552536004123	OxaA-like protein precursor; Validated; Region: PRK01622
552536004124	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
552536004125	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536004126	dimerization interface [polypeptide binding]; other site
552536004127	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536004128	dimer interface [polypeptide binding]; other site
552536004129	phosphorylation site [posttranslational modification]
552536004130	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536004131	ATP binding site [chemical binding]; other site
552536004132	Mg2+ binding site [ion binding]; other site
552536004133	G-X-G motif; other site
552536004134	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536004135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536004136	active site
552536004137	phosphorylation site [posttranslational modification]
552536004138	intermolecular recognition site; other site
552536004139	dimerization interface [polypeptide binding]; other site
552536004140	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536004141	DNA binding site [nucleotide binding]
552536004142	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
552536004143	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
552536004144	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
552536004145	peptidase T-like protein; Region: PepT-like; TIGR01883
552536004146	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
552536004147	metal binding site [ion binding]; metal-binding site
552536004148	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
552536004149	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
552536004150	E3 interaction surface; other site
552536004151	lipoyl attachment site [posttranslational modification]; other site
552536004152	e3 binding domain; Region: E3_binding; pfam02817
552536004153	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
552536004154	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
552536004155	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
552536004156	alpha subunit interface [polypeptide binding]; other site
552536004157	TPP binding site [chemical binding]; other site
552536004158	heterodimer interface [polypeptide binding]; other site
552536004159	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552536004160	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
552536004161	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
552536004162	tetramer interface [polypeptide binding]; other site
552536004163	TPP-binding site [chemical binding]; other site
552536004164	heterodimer interface [polypeptide binding]; other site
552536004165	phosphorylation loop region [posttranslational modification]
552536004166	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
552536004167	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536004168	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
552536004169	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536004170	nucleotide binding site [chemical binding]; other site
552536004171	Acetokinase family; Region: Acetate_kinase; cl17229
552536004172	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
552536004173	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
552536004174	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
552536004175	Walker A/P-loop; other site
552536004176	ATP binding site [chemical binding]; other site
552536004177	Q-loop/lid; other site
552536004178	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
552536004179	ABC transporter signature motif; other site
552536004180	Walker B; other site
552536004181	D-loop; other site
552536004182	H-loop/switch region; other site
552536004183	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
552536004184	arginine repressor; Provisional; Region: PRK04280
552536004185	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
552536004186	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
552536004187	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536004188	RNA binding surface [nucleotide binding]; other site
552536004189	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
552536004190	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
552536004191	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
552536004192	TPP-binding site; other site
552536004193	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552536004194	PYR/PP interface [polypeptide binding]; other site
552536004195	dimer interface [polypeptide binding]; other site
552536004196	TPP binding site [chemical binding]; other site
552536004197	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552536004198	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
552536004199	DNA-binding site [nucleotide binding]; DNA binding site
552536004200	RNA-binding motif; other site
552536004201	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
552536004202	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
552536004203	substrate binding pocket [chemical binding]; other site
552536004204	chain length determination region; other site
552536004205	substrate-Mg2+ binding site; other site
552536004206	catalytic residues [active]
552536004207	aspartate-rich region 1; other site
552536004208	active site lid residues [active]
552536004209	aspartate-rich region 2; other site
552536004210	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
552536004211	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
552536004212	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
552536004213	generic binding surface II; other site
552536004214	generic binding surface I; other site
552536004215	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
552536004216	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
552536004217	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
552536004218	homodimer interface [polypeptide binding]; other site
552536004219	NADP binding site [chemical binding]; other site
552536004220	substrate binding site [chemical binding]; other site
552536004221	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
552536004222	putative RNA binding site [nucleotide binding]; other site
552536004223	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
552536004224	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
552536004225	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552536004226	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552536004227	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
552536004228	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
552536004229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
552536004230	carboxyltransferase (CT) interaction site; other site
552536004231	biotinylation site [posttranslational modification]; other site
552536004232	elongation factor P; Validated; Region: PRK00529
552536004233	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
552536004234	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
552536004235	RNA binding site [nucleotide binding]; other site
552536004236	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
552536004237	RNA binding site [nucleotide binding]; other site
552536004238	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
552536004239	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
552536004240	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
552536004241	active site
552536004242	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
552536004243	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
552536004244	active site residue [active]
552536004245	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
552536004246	tetramer interface [polypeptide binding]; other site
552536004247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536004248	catalytic residue [active]
552536004249	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
552536004250	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
552536004251	tetramer interface [polypeptide binding]; other site
552536004252	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536004253	catalytic residue [active]
552536004254	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
552536004255	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
552536004256	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
552536004257	Type II/IV secretion system protein; Region: T2SE; pfam00437
552536004258	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552536004259	Walker A motif; other site
552536004260	ATP binding site [chemical binding]; other site
552536004261	Walker B motif; other site
552536004262	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
552536004263	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
552536004264	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
552536004265	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
552536004266	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
552536004267	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
552536004268	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536004269	nucleotide binding site [chemical binding]; other site
552536004270	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
552536004271	Rhomboid family; Region: Rhomboid; pfam01694
552536004272	TPR repeat; Region: TPR_11; pfam13414
552536004273	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
552536004274	TPR motif; other site
552536004275	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
552536004276	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
552536004277	YceG-like family; Region: YceG; pfam02618
552536004278	GTPase RsgA; Reviewed; Region: PRK01889
552536004279	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
552536004280	RNA binding site [nucleotide binding]; other site
552536004281	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
552536004282	GTPase/Zn-binding domain interface [polypeptide binding]; other site
552536004283	GTP/Mg2+ binding site [chemical binding]; other site
552536004284	G4 box; other site
552536004285	G5 box; other site
552536004286	G1 box; other site
552536004287	Switch I region; other site
552536004288	G2 box; other site
552536004289	G3 box; other site
552536004290	Switch II region; other site
552536004291	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
552536004292	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
552536004293	RNase E interface [polypeptide binding]; other site
552536004294	trimer interface [polypeptide binding]; other site
552536004295	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
552536004296	RNase E interface [polypeptide binding]; other site
552536004297	trimer interface [polypeptide binding]; other site
552536004298	active site
552536004299	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
552536004300	putative nucleic acid binding region [nucleotide binding]; other site
552536004301	G-X-X-G motif; other site
552536004302	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
552536004303	RNA binding site [nucleotide binding]; other site
552536004304	domain interface; other site
552536004305	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
552536004306	16S/18S rRNA binding site [nucleotide binding]; other site
552536004307	S13e-L30e interaction site [polypeptide binding]; other site
552536004308	25S rRNA binding site [nucleotide binding]; other site
552536004309	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
552536004310	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
552536004311	active site
552536004312	Riboflavin kinase; Region: Flavokinase; smart00904
552536004313	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
552536004314	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
552536004315	RNA binding site [nucleotide binding]; other site
552536004316	active site
552536004317	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
552536004318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
552536004319	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
552536004320	translation initiation factor IF-2; Region: IF-2; TIGR00487
552536004321	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
552536004322	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
552536004323	G1 box; other site
552536004324	putative GEF interaction site [polypeptide binding]; other site
552536004325	GTP/Mg2+ binding site [chemical binding]; other site
552536004326	Switch I region; other site
552536004327	G2 box; other site
552536004328	G3 box; other site
552536004329	Switch II region; other site
552536004330	G4 box; other site
552536004331	G5 box; other site
552536004332	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
552536004333	Translation-initiation factor 2; Region: IF-2; pfam11987
552536004334	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
552536004335	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
552536004336	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
552536004337	putative RNA binding cleft [nucleotide binding]; other site
552536004338	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
552536004339	NusA N-terminal domain; Region: NusA_N; pfam08529
552536004340	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
552536004341	RNA binding site [nucleotide binding]; other site
552536004342	homodimer interface [polypeptide binding]; other site
552536004343	NusA-like KH domain; Region: KH_5; pfam13184
552536004344	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
552536004345	G-X-X-G motif; other site
552536004346	ribosome maturation protein RimP; Reviewed; Region: PRK00092
552536004347	Sm and related proteins; Region: Sm_like; cl00259
552536004348	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
552536004349	putative oligomer interface [polypeptide binding]; other site
552536004350	putative RNA binding site [nucleotide binding]; other site
552536004351	DNA polymerase III PolC; Validated; Region: polC; PRK00448
552536004352	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
552536004353	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
552536004354	generic binding surface II; other site
552536004355	generic binding surface I; other site
552536004356	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
552536004357	active site
552536004358	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
552536004359	active site
552536004360	catalytic site [active]
552536004361	substrate binding site [chemical binding]; other site
552536004362	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
552536004363	prolyl-tRNA synthetase; Provisional; Region: PRK09194
552536004364	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
552536004365	dimer interface [polypeptide binding]; other site
552536004366	motif 1; other site
552536004367	active site
552536004368	motif 2; other site
552536004369	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
552536004370	putative deacylase active site [active]
552536004371	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552536004372	active site
552536004373	motif 3; other site
552536004374	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
552536004375	anticodon binding site; other site
552536004376	RIP metalloprotease RseP; Region: TIGR00054
552536004377	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
552536004378	active site
552536004379	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
552536004380	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
552536004381	protein binding site [polypeptide binding]; other site
552536004382	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
552536004383	putative substrate binding region [chemical binding]; other site
552536004384	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
552536004385	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
552536004386	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
552536004387	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
552536004388	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
552536004389	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
552536004390	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
552536004391	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
552536004392	catalytic residue [active]
552536004393	putative FPP diphosphate  binding site; other site
552536004394	putative FPP binding hydrophobic cleft; other site
552536004395	dimer interface [polypeptide binding]; other site
552536004396	putative IPP diphosphate binding site; other site
552536004397	ribosome recycling factor; Reviewed; Region: frr; PRK00083
552536004398	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
552536004399	hinge region; other site
552536004400	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
552536004401	putative nucleotide binding site [chemical binding]; other site
552536004402	uridine monophosphate binding site [chemical binding]; other site
552536004403	homohexameric interface [polypeptide binding]; other site
552536004404	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536004405	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552536004406	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
552536004407	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
552536004408	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
552536004409	Active Sites [active]
552536004410	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
552536004411	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
552536004412	ParB-like nuclease domain; Region: ParBc; pfam02195
552536004413	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
552536004414	Methyltransferase domain; Region: Methyltransf_31; pfam13847
552536004415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536004416	S-adenosylmethionine binding site [chemical binding]; other site
552536004417	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
552536004418	hypothetical protein; Provisional; Region: PRK01844
552536004419	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
552536004420	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
552536004421	TPP-binding site [chemical binding]; other site
552536004422	dimer interface [polypeptide binding]; other site
552536004423	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552536004424	PYR/PP interface [polypeptide binding]; other site
552536004425	dimer interface [polypeptide binding]; other site
552536004426	TPP binding site [chemical binding]; other site
552536004427	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552536004428	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
552536004429	cell division suppressor protein YneA; Provisional; Region: PRK14125
552536004430	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
552536004431	LexA repressor; Validated; Region: PRK00215
552536004432	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536004433	putative DNA binding site [nucleotide binding]; other site
552536004434	putative Zn2+ binding site [ion binding]; other site
552536004435	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
552536004436	Catalytic site [active]
552536004437	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552536004438	arsenical pump membrane protein; Provisional; Region: PRK15445
552536004439	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
552536004440	transmembrane helices; other site
552536004441	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
552536004442	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
552536004443	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
552536004444	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
552536004445	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552536004446	DNA binding residues [nucleotide binding]
552536004447	putative dimer interface [polypeptide binding]; other site
552536004448	glycophorin-binding protein; Provisional; Region: PTZ00131
552536004449	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
552536004450	Aluminium resistance protein; Region: Alum_res; pfam06838
552536004451	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
552536004452	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
552536004453	HflX GTPase family; Region: HflX; cd01878
552536004454	G1 box; other site
552536004455	GTP/Mg2+ binding site [chemical binding]; other site
552536004456	Switch I region; other site
552536004457	G2 box; other site
552536004458	G3 box; other site
552536004459	Switch II region; other site
552536004460	G4 box; other site
552536004461	G5 box; other site
552536004462	bacterial Hfq-like; Region: Hfq; cd01716
552536004463	hexamer interface [polypeptide binding]; other site
552536004464	Sm1 motif; other site
552536004465	RNA binding site [nucleotide binding]; other site
552536004466	Sm2 motif; other site
552536004467	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
552536004468	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
552536004469	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
552536004470	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
552536004471	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
552536004472	active site
552536004473	catalytic site [active]
552536004474	metal binding site [ion binding]; metal-binding site
552536004475	dimer interface [polypeptide binding]; other site
552536004476	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
552536004477	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
552536004478	catalytic triad [active]
552536004479	catalytic triad [active]
552536004480	oxyanion hole [active]
552536004481	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536004482	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536004483	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536004484	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536004485	S-ribosylhomocysteinase; Provisional; Region: PRK02260
552536004486	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
552536004487	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
552536004488	CAP-like domain; other site
552536004489	active site
552536004490	primary dimer interface [polypeptide binding]; other site
552536004491	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536004492	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536004493	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
552536004494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536004495	Mg2+ binding site [ion binding]; other site
552536004496	G-X-G motif; other site
552536004497	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
552536004498	anchoring element; other site
552536004499	dimer interface [polypeptide binding]; other site
552536004500	ATP binding site [chemical binding]; other site
552536004501	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
552536004502	active site
552536004503	putative metal-binding site [ion binding]; other site
552536004504	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
552536004505	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
552536004506	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
552536004507	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
552536004508	active site
552536004509	catalytic residues [active]
552536004510	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
552536004511	active site
552536004512	transcriptional repressor CodY; Validated; Region: PRK04158
552536004513	CodY GAF-like domain; Region: CodY; pfam06018
552536004514	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
552536004515	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
552536004516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536004517	Walker A motif; other site
552536004518	ATP binding site [chemical binding]; other site
552536004519	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
552536004520	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
552536004521	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
552536004522	active site
552536004523	HslU subunit interaction site [polypeptide binding]; other site
552536004524	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
552536004525	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
552536004526	active site
552536004527	DNA binding site [nucleotide binding]
552536004528	Int/Topo IB signature motif; other site
552536004529	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
552536004530	Glucose inhibited division protein A; Region: GIDA; pfam01134
552536004531	DNA topoisomerase I; Validated; Region: PRK05582
552536004532	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
552536004533	active site
552536004534	interdomain interaction site; other site
552536004535	putative metal-binding site [ion binding]; other site
552536004536	nucleotide binding site [chemical binding]; other site
552536004537	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
552536004538	domain I; other site
552536004539	DNA binding groove [nucleotide binding]
552536004540	phosphate binding site [ion binding]; other site
552536004541	domain II; other site
552536004542	domain III; other site
552536004543	nucleotide binding site [chemical binding]; other site
552536004544	catalytic site [active]
552536004545	domain IV; other site
552536004546	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
552536004547	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
552536004548	DNA protecting protein DprA; Region: dprA; TIGR00732
552536004549	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
552536004550	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
552536004551	RNA/DNA hybrid binding site [nucleotide binding]; other site
552536004552	active site
552536004553	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
552536004554	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
552536004555	GTP/Mg2+ binding site [chemical binding]; other site
552536004556	G4 box; other site
552536004557	G5 box; other site
552536004558	G1 box; other site
552536004559	Switch I region; other site
552536004560	G2 box; other site
552536004561	G3 box; other site
552536004562	Switch II region; other site
552536004563	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
552536004564	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552536004565	Catalytic site [active]
552536004566	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552536004567	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
552536004568	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552536004569	Catalytic site [active]
552536004570	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
552536004571	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
552536004572	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552536004573	Catalytic site [active]
552536004574	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552536004575	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
552536004576	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
552536004577	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536004578	Walker A motif; other site
552536004579	ATP binding site [chemical binding]; other site
552536004580	Walker B motif; other site
552536004581	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
552536004582	trigger factor; Provisional; Region: tig; PRK01490
552536004583	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
552536004584	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
552536004585	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536004586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536004587	non-specific DNA binding site [nucleotide binding]; other site
552536004588	salt bridge; other site
552536004589	sequence-specific DNA binding site [nucleotide binding]; other site
552536004590	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
552536004591	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
552536004592	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
552536004593	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
552536004594	nucleotide binding site [chemical binding]; other site
552536004595	homotetrameric interface [polypeptide binding]; other site
552536004596	putative phosphate binding site [ion binding]; other site
552536004597	putative allosteric binding site; other site
552536004598	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
552536004599	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
552536004600	putative catalytic cysteine [active]
552536004601	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
552536004602	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552536004603	Protein of unknown function (DUF877); Region: DUF877; cl05484
552536004604	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
552536004605	nudix motif; other site
552536004606	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
552536004607	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
552536004608	active site turn [active]
552536004609	phosphorylation site [posttranslational modification]
552536004610	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
552536004611	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
552536004612	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
552536004613	Ca binding site [ion binding]; other site
552536004614	active site
552536004615	catalytic site [active]
552536004616	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
552536004617	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536004618	DNA-binding site [nucleotide binding]; DNA binding site
552536004619	UTRA domain; Region: UTRA; pfam07702
552536004620	Uncharacterized conserved protein [Function unknown]; Region: COG1284
552536004621	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
552536004622	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
552536004623	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536004624	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536004625	ligand binding site [chemical binding]; other site
552536004626	flexible hinge region; other site
552536004627	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
552536004628	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536004629	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536004630	putative substrate translocation pore; other site
552536004631	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
552536004632	putative active site [active]
552536004633	nucleotide binding site [chemical binding]; other site
552536004634	nudix motif; other site
552536004635	putative metal binding site [ion binding]; other site
552536004636	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
552536004637	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
552536004638	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
552536004639	ATP binding site [chemical binding]; other site
552536004640	Mg++ binding site [ion binding]; other site
552536004641	motif III; other site
552536004642	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536004643	nucleotide binding region [chemical binding]; other site
552536004644	ATP-binding site [chemical binding]; other site
552536004645	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
552536004646	RNA binding site [nucleotide binding]; other site
552536004647	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536004648	catalytic core [active]
552536004649	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
552536004650	dimer interface [polypeptide binding]; other site
552536004651	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
552536004652	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
552536004653	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
552536004654	Uncharacterized conserved protein [Function unknown]; Region: COG5361
552536004655	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
552536004656	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
552536004657	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536004658	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536004659	LRR adjacent; Region: LRR_adjacent; pfam08191
552536004660	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004661	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004662	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004663	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004664	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536004665	SUKH-3 immunity protein; Region: SUKH-3; pfam14433
552536004666	Helix-turn-helix domain; Region: HTH_16; pfam12645
552536004667	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
552536004668	Cna protein B-type domain; Region: Cna_B; pfam05738
552536004669	Cna protein B-type domain; Region: Cna_B; pfam05738
552536004670	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
552536004671	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
552536004672	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
552536004673	Bacterial SH3 domain; Region: SH3_3; cl17532
552536004674	Bacterial SH3 domain; Region: SH3_3; cl17532
552536004675	Bacteriophage holin; Region: Phage_holin_1; pfam04531
552536004676	Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900
552536004677	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
552536004678	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
552536004679	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
552536004680	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
552536004681	Phage tail protein; Region: Sipho_tail; pfam05709
552536004682	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
552536004683	N-acetyl-D-glucosamine binding site [chemical binding]; other site
552536004684	catalytic residue [active]
552536004685	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
552536004686	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
552536004687	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
552536004688	Phage capsid family; Region: Phage_capsid; pfam05065
552536004689	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
552536004690	oligomer interface [polypeptide binding]; other site
552536004691	active site residues [active]
552536004692	Phage portal protein; Region: Phage_portal; pfam04860
552536004693	Phage-related protein [Function unknown]; Region: COG4695; cl01923
552536004694	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
552536004695	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
552536004696	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
552536004697	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
552536004698	active site
552536004699	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
552536004700	putative active site [active]
552536004701	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
552536004702	Protein of unknown function (DUF722); Region: DUF722; pfam05263
552536004703	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
552536004704	VRR-NUC domain; Region: VRR_NUC; pfam08774
552536004705	Uncharacterized conserved protein [Function unknown]; Region: COG4983
552536004706	Phage associated DNA primase [General function prediction only]; Region: COG3378
552536004707	D5 N terminal like; Region: D5_N; pfam08706
552536004708	Poxvirus D5 protein-like; Region: Pox_D5; pfam03288
552536004709	Protein of unknown function (DUF669); Region: DUF669; pfam05037
552536004710	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
552536004711	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536004712	putative Mg++ binding site [ion binding]; other site
552536004713	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536004714	nucleotide binding region [chemical binding]; other site
552536004715	ATP-binding site [chemical binding]; other site
552536004716	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
552536004717	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
552536004718	AAA domain; Region: AAA_24; pfam13479
552536004719	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
552536004720	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
552536004721	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
552536004722	hypothetical protein; Provisional; Region: PRK10220
552536004723	YopX protein; Region: YopX; cl09859
552536004724	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
552536004725	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
552536004726	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
552536004727	cofactor binding site; other site
552536004728	DNA binding site [nucleotide binding]
552536004729	substrate interaction site [chemical binding]; other site
552536004730	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536004731	salt bridge; other site
552536004732	non-specific DNA binding site [nucleotide binding]; other site
552536004733	sequence-specific DNA binding site [nucleotide binding]; other site
552536004734	Protein of unknown function (DUF1250); Region: DUF1250; pfam06855
552536004735	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536004736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536004737	non-specific DNA binding site [nucleotide binding]; other site
552536004738	salt bridge; other site
552536004739	sequence-specific DNA binding site [nucleotide binding]; other site
552536004740	Domain of unknown function (DUF955); Region: DUF955; pfam06114
552536004741	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
552536004742	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
552536004743	Int/Topo IB signature motif; other site
552536004744	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
552536004745	active site
552536004746	metal binding site [ion binding]; metal-binding site
552536004747	homotetramer interface [polypeptide binding]; other site
552536004748	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
552536004749	active site
552536004750	dimerization interface [polypeptide binding]; other site
552536004751	ribonuclease PH; Reviewed; Region: rph; PRK00173
552536004752	Ribonuclease PH; Region: RNase_PH_bact; cd11362
552536004753	hexamer interface [polypeptide binding]; other site
552536004754	active site
552536004755	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
552536004756	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
552536004757	aspartate kinase; Reviewed; Region: PRK06635
552536004758	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
552536004759	putative nucleotide binding site [chemical binding]; other site
552536004760	putative catalytic residues [active]
552536004761	putative Mg ion binding site [ion binding]; other site
552536004762	putative aspartate binding site [chemical binding]; other site
552536004763	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
552536004764	putative allosteric regulatory site; other site
552536004765	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
552536004766	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
552536004767	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
552536004768	GIY-YIG motif/motif A; other site
552536004769	active site
552536004770	catalytic site [active]
552536004771	putative DNA binding site [nucleotide binding]; other site
552536004772	metal binding site [ion binding]; metal-binding site
552536004773	UvrB/uvrC motif; Region: UVR; pfam02151
552536004774	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
552536004775	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536004776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
552536004777	catalytic residues [active]
552536004778	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
552536004779	MutS domain III; Region: MutS_III; pfam05192
552536004780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536004781	Walker A/P-loop; other site
552536004782	ATP binding site [chemical binding]; other site
552536004783	Q-loop/lid; other site
552536004784	ABC transporter signature motif; other site
552536004785	Walker B; other site
552536004786	D-loop; other site
552536004787	H-loop/switch region; other site
552536004788	Smr domain; Region: Smr; pfam01713
552536004789	hypothetical protein; Provisional; Region: PRK08609
552536004790	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
552536004791	active site
552536004792	primer binding site [nucleotide binding]; other site
552536004793	NTP  binding site [chemical binding]; other site
552536004794	metal binding triad [ion binding]; metal-binding site
552536004795	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
552536004796	active site
552536004797	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
552536004798	Colicin V production protein; Region: Colicin_V; pfam02674
552536004799	Cell division protein ZapA; Region: ZapA; cl01146
552536004800	ribonuclease HIII; Provisional; Region: PRK00996
552536004801	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
552536004802	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
552536004803	RNA/DNA hybrid binding site [nucleotide binding]; other site
552536004804	active site
552536004805	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
552536004806	ligand binding site [chemical binding]; other site
552536004807	active site
552536004808	UGI interface [polypeptide binding]; other site
552536004809	catalytic site [active]
552536004810	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
552536004811	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
552536004812	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552536004813	MarR family; Region: MarR; pfam01047
552536004814	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536004815	Protein of unknown function (DUF1090); Region: DUF1090; pfam06476
552536004816	FtsX-like permease family; Region: FtsX; pfam02687
552536004817	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
552536004818	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536004819	FtsX-like permease family; Region: FtsX; pfam02687
552536004820	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536004821	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536004822	Walker A/P-loop; other site
552536004823	ATP binding site [chemical binding]; other site
552536004824	Q-loop/lid; other site
552536004825	ABC transporter signature motif; other site
552536004826	Walker B; other site
552536004827	D-loop; other site
552536004828	H-loop/switch region; other site
552536004829	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
552536004830	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
552536004831	putative tRNA-binding site [nucleotide binding]; other site
552536004832	B3/4 domain; Region: B3_4; pfam03483
552536004833	tRNA synthetase B5 domain; Region: B5; smart00874
552536004834	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
552536004835	dimer interface [polypeptide binding]; other site
552536004836	motif 1; other site
552536004837	motif 3; other site
552536004838	motif 2; other site
552536004839	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
552536004840	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
552536004841	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
552536004842	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
552536004843	dimer interface [polypeptide binding]; other site
552536004844	motif 1; other site
552536004845	active site
552536004846	motif 2; other site
552536004847	motif 3; other site
552536004848	Predicted transcriptional regulators [Transcription]; Region: COG1733
552536004849	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
552536004850	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
552536004851	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
552536004852	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
552536004853	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
552536004854	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
552536004855	oligomer interface [polypeptide binding]; other site
552536004856	active site
552536004857	metal binding site [ion binding]; metal-binding site
552536004858	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536004859	SH3-like domain; Region: SH3_8; pfam13457
552536004860	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536004861	SH3-like domain; Region: SH3_8; pfam13457
552536004862	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
552536004863	AAA domain; Region: AAA_17; pfam13207
552536004864	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
552536004865	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
552536004866	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
552536004867	cobyric acid synthase; Provisional; Region: PRK00784
552536004868	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552536004869	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552536004870	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
552536004871	catalytic triad [active]
552536004872	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
552536004873	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552536004874	Walker A/P-loop; other site
552536004875	ATP binding site [chemical binding]; other site
552536004876	Q-loop/lid; other site
552536004877	ABC transporter signature motif; other site
552536004878	Walker B; other site
552536004879	D-loop; other site
552536004880	H-loop/switch region; other site
552536004881	cobalt transport protein CbiQ; Provisional; Region: PRK15485
552536004882	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
552536004883	cobalt transport protein CbiM; Validated; Region: PRK08319
552536004884	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
552536004885	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
552536004886	active site
552536004887	SAM binding site [chemical binding]; other site
552536004888	homodimer interface [polypeptide binding]; other site
552536004889	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
552536004890	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
552536004891	active site
552536004892	C-terminal domain interface [polypeptide binding]; other site
552536004893	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
552536004894	active site
552536004895	N-terminal domain interface [polypeptide binding]; other site
552536004896	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
552536004897	active site
552536004898	SAM binding site [chemical binding]; other site
552536004899	homodimer interface [polypeptide binding]; other site
552536004900	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
552536004901	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
552536004902	active site
552536004903	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
552536004904	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
552536004905	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
552536004906	active site
552536004907	SAM binding site [chemical binding]; other site
552536004908	homodimer interface [polypeptide binding]; other site
552536004909	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
552536004910	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
552536004911	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
552536004912	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
552536004913	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
552536004914	active site
552536004915	SAM binding site [chemical binding]; other site
552536004916	homodimer interface [polypeptide binding]; other site
552536004917	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
552536004918	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536004919	S-adenosylmethionine binding site [chemical binding]; other site
552536004920	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
552536004921	active site
552536004922	putative homodimer interface [polypeptide binding]; other site
552536004923	SAM binding site [chemical binding]; other site
552536004924	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
552536004925	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
552536004926	Precorrin-8X methylmutase; Region: CbiC; pfam02570
552536004927	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
552536004928	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
552536004929	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
552536004930	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
552536004931	catalytic triad [active]
552536004932	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
552536004933	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
552536004934	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536004935	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536004936	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536004937	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
552536004938	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
552536004939	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
552536004940	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
552536004941	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
552536004942	putative hexamer interface [polypeptide binding]; other site
552536004943	putative hexagonal pore; other site
552536004944	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
552536004945	putative hexamer interface [polypeptide binding]; other site
552536004946	putative hexagonal pore; other site
552536004947	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
552536004948	Hexamer/Pentamer interface [polypeptide binding]; other site
552536004949	central pore; other site
552536004950	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
552536004951	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
552536004952	Propanediol utilisation protein PduL; Region: PduL; pfam06130
552536004953	Propanediol utilisation protein PduL; Region: PduL; pfam06130
552536004954	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
552536004955	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536004956	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
552536004957	Hexamer interface [polypeptide binding]; other site
552536004958	Putative hexagonal pore residue; other site
552536004959	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
552536004960	putative catalytic cysteine [active]
552536004961	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536004962	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
552536004963	Hexamer interface [polypeptide binding]; other site
552536004964	Hexagonal pore residue; other site
552536004965	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
552536004966	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
552536004967	putative hexamer interface [polypeptide binding]; other site
552536004968	putative hexagonal pore; other site
552536004969	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
552536004970	putative hexamer interface [polypeptide binding]; other site
552536004971	putative hexagonal pore; other site
552536004972	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
552536004973	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
552536004974	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
552536004975	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
552536004976	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
552536004977	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
552536004978	Histidine kinase; Region: HisKA_2; pfam07568
552536004979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536004980	ATP binding site [chemical binding]; other site
552536004981	Mg2+ binding site [ion binding]; other site
552536004982	G-X-G motif; other site
552536004983	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
552536004984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536004985	active site
552536004986	phosphorylation site [posttranslational modification]
552536004987	intermolecular recognition site; other site
552536004988	dimerization interface [polypeptide binding]; other site
552536004989	ANTAR domain; Region: ANTAR; pfam03861
552536004990	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
552536004991	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
552536004992	putative active site [active]
552536004993	metal binding site [ion binding]; metal-binding site
552536004994	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
552536004995	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
552536004996	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536004997	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536004998	homodimer interface [polypeptide binding]; other site
552536004999	catalytic residue [active]
552536005000	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
552536005001	propionate/acetate kinase; Provisional; Region: PRK12379
552536005002	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
552536005003	amphipathic channel; other site
552536005004	Asn-Pro-Ala signature motifs; other site
552536005005	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
552536005006	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
552536005007	putative active site [active]
552536005008	metal binding site [ion binding]; metal-binding site
552536005009	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
552536005010	putative catalytic cysteine [active]
552536005011	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
552536005012	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
552536005013	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
552536005014	Hexamer/Pentamer interface [polypeptide binding]; other site
552536005015	central pore; other site
552536005016	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
552536005017	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
552536005018	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536005019	nucleotide binding site [chemical binding]; other site
552536005020	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
552536005021	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
552536005022	Propanediol utilisation protein PduL; Region: PduL; pfam06130
552536005023	Propanediol utilisation protein PduL; Region: PduL; pfam06130
552536005024	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536005025	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
552536005026	Hexamer interface [polypeptide binding]; other site
552536005027	Hexagonal pore residue; other site
552536005028	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536005029	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
552536005030	putative hexamer interface [polypeptide binding]; other site
552536005031	putative hexagonal pore; other site
552536005032	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
552536005033	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
552536005034	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
552536005035	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
552536005036	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
552536005037	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
552536005038	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
552536005039	alpha-beta subunit interface [polypeptide binding]; other site
552536005040	alpha-gamma subunit interface [polypeptide binding]; other site
552536005041	active site
552536005042	substrate and K+ binding site; other site
552536005043	K+ binding site [ion binding]; other site
552536005044	cobalamin binding site [chemical binding]; other site
552536005045	propanediol utilization protein PduB; Provisional; Region: PRK15415
552536005046	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
552536005047	putative hexamer interface [polypeptide binding]; other site
552536005048	putative hexagonal pore; other site
552536005049	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
552536005050	putative hexamer interface [polypeptide binding]; other site
552536005051	putative hexagonal pore; other site
552536005052	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536005053	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
552536005054	Hexamer interface [polypeptide binding]; other site
552536005055	Hexagonal pore residue; other site
552536005056	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
552536005057	Sensory domain found in PocR; Region: PocR; pfam10114
552536005058	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536005059	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536005060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536005061	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536005062	catalytic core [active]
552536005063	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
552536005064	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
552536005065	homotrimer interface [polypeptide binding]; other site
552536005066	Walker A motif; other site
552536005067	GTP binding site [chemical binding]; other site
552536005068	Walker B motif; other site
552536005069	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
552536005070	G1 box; other site
552536005071	GTP/Mg2+ binding site [chemical binding]; other site
552536005072	G2 box; other site
552536005073	Switch I region; other site
552536005074	G3 box; other site
552536005075	Switch II region; other site
552536005076	G4 box; other site
552536005077	G5 box; other site
552536005078	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
552536005079	putative hexamer interface [polypeptide binding]; other site
552536005080	putative hexagonal pore; other site
552536005081	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
552536005082	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
552536005083	putative hexamer interface [polypeptide binding]; other site
552536005084	putative hexagonal pore; other site
552536005085	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
552536005086	putative hexamer interface [polypeptide binding]; other site
552536005087	putative hexagonal pore; other site
552536005088	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
552536005089	SLBB domain; Region: SLBB; pfam10531
552536005090	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
552536005091	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
552536005092	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
552536005093	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
552536005094	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
552536005095	dimer interface [polypeptide binding]; other site
552536005096	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536005097	Clp protease; Region: CLP_protease; pfam00574
552536005098	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
552536005099	oligomer interface [polypeptide binding]; other site
552536005100	active site residues [active]
552536005101	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
552536005102	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536005103	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536005104	LRR adjacent; Region: LRR_adjacent; pfam08191
552536005105	Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206
552536005106	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552536005107	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536005108	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536005109	DNA binding residues [nucleotide binding]
552536005110	putative dimer interface [polypeptide binding]; other site
552536005111	Uncharacterized conserved protein [Function unknown]; Region: COG1359
552536005112	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536005113	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536005114	Walker A/P-loop; other site
552536005115	ATP binding site [chemical binding]; other site
552536005116	Q-loop/lid; other site
552536005117	ABC transporter signature motif; other site
552536005118	Walker B; other site
552536005119	D-loop; other site
552536005120	H-loop/switch region; other site
552536005121	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
552536005122	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536005123	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536005124	Walker A/P-loop; other site
552536005125	ATP binding site [chemical binding]; other site
552536005126	Q-loop/lid; other site
552536005127	ABC transporter signature motif; other site
552536005128	Walker B; other site
552536005129	D-loop; other site
552536005130	H-loop/switch region; other site
552536005131	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536005132	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
552536005133	DNA binding residues [nucleotide binding]
552536005134	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552536005135	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536005136	Coenzyme A binding pocket [chemical binding]; other site
552536005137	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
552536005138	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552536005139	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
552536005140	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536005141	Coenzyme A binding pocket [chemical binding]; other site
552536005142	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
552536005143	GMP synthase; Reviewed; Region: guaA; PRK00074
552536005144	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
552536005145	AMP/PPi binding site [chemical binding]; other site
552536005146	candidate oxyanion hole; other site
552536005147	catalytic triad [active]
552536005148	potential glutamine specificity residues [chemical binding]; other site
552536005149	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
552536005150	ATP Binding subdomain [chemical binding]; other site
552536005151	Dimerization subdomain; other site
552536005152	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
552536005153	active site
552536005154	P-loop; other site
552536005155	phosphorylation site [posttranslational modification]
552536005156	Uncharacterized conserved protein [Function unknown]; Region: COG1359
552536005157	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
552536005158	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
552536005159	homodimer interface [polypeptide binding]; other site
552536005160	NAD binding pocket [chemical binding]; other site
552536005161	ATP binding pocket [chemical binding]; other site
552536005162	Mg binding site [ion binding]; other site
552536005163	active-site loop [active]
552536005164	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
552536005165	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
552536005166	active site
552536005167	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
552536005168	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
552536005169	active site
552536005170	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
552536005171	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
552536005172	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
552536005173	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
552536005174	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
552536005175	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
552536005176	active site
552536005177	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
552536005178	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552536005179	putative NAD(P) binding site [chemical binding]; other site
552536005180	putative catalytic Zn binding site [ion binding]; other site
552536005181	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
552536005182	substrate binding site; other site
552536005183	dimer interface; other site
552536005184	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
552536005185	active site
552536005186	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
552536005187	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
552536005188	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
552536005189	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
552536005190	active site
552536005191	tetramer interface; other site
552536005192	conserved hypothetical integral membrane protein; Region: TIGR03766
552536005193	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
552536005194	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
552536005195	Ligand binding site; other site
552536005196	Putative Catalytic site; other site
552536005197	DXD motif; other site
552536005198	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536005199	SH3-like domain; Region: SH3_8; pfam13457
552536005200	SH3-like domain; Region: SH3_8; pfam13457
552536005201	SH3-like domain; Region: SH3_8; pfam13457
552536005202	SH3-like domain; Region: SH3_8; pfam13457
552536005203	SH3-like domain; Region: SH3_8; pfam13457
552536005204	SH3-like domain; Region: SH3_8; pfam13457
552536005205	SH3-like domain; Region: SH3_8; pfam13457
552536005206	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
552536005207	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
552536005208	Walker A/P-loop; other site
552536005209	ATP binding site [chemical binding]; other site
552536005210	Q-loop/lid; other site
552536005211	ABC transporter signature motif; other site
552536005212	Walker B; other site
552536005213	D-loop; other site
552536005214	H-loop/switch region; other site
552536005215	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
552536005216	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
552536005217	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
552536005218	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
552536005219	putative binding site residues; other site
552536005220	pyruvate carboxylase; Reviewed; Region: PRK12999
552536005221	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552536005222	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
552536005223	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
552536005224	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
552536005225	active site
552536005226	catalytic residues [active]
552536005227	metal binding site [ion binding]; metal-binding site
552536005228	homodimer binding site [polypeptide binding]; other site
552536005229	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
552536005230	carboxyltransferase (CT) interaction site; other site
552536005231	biotinylation site [posttranslational modification]; other site
552536005232	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
552536005233	hypothetical protein; Provisional; Region: PRK13666
552536005234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
552536005235	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
552536005236	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
552536005237	G1 box; other site
552536005238	putative GEF interaction site [polypeptide binding]; other site
552536005239	GTP/Mg2+ binding site [chemical binding]; other site
552536005240	Switch I region; other site
552536005241	G2 box; other site
552536005242	G3 box; other site
552536005243	Switch II region; other site
552536005244	G4 box; other site
552536005245	G5 box; other site
552536005246	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
552536005247	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
552536005248	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
552536005249	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
552536005250	active site
552536005251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
552536005252	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
552536005253	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
552536005254	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
552536005255	Cl binding site [ion binding]; other site
552536005256	oligomer interface [polypeptide binding]; other site
552536005257	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
552536005258	DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972
552536005259	catalytic residues [active]
552536005260	Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256
552536005261	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
552536005262	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
552536005263	NAD(P) binding site [chemical binding]; other site
552536005264	LDH/MDH dimer interface [polypeptide binding]; other site
552536005265	substrate binding site [chemical binding]; other site
552536005266	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
552536005267	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552536005268	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536005269	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
552536005270	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
552536005271	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
552536005272	E3 interaction surface; other site
552536005273	lipoyl attachment site [posttranslational modification]; other site
552536005274	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
552536005275	E3 interaction surface; other site
552536005276	lipoyl attachment site [posttranslational modification]; other site
552536005277	e3 binding domain; Region: E3_binding; pfam02817
552536005278	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
552536005279	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
552536005280	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
552536005281	alpha subunit interface [polypeptide binding]; other site
552536005282	TPP binding site [chemical binding]; other site
552536005283	heterodimer interface [polypeptide binding]; other site
552536005284	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552536005285	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
552536005286	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
552536005287	TPP-binding site [chemical binding]; other site
552536005288	tetramer interface [polypeptide binding]; other site
552536005289	heterodimer interface [polypeptide binding]; other site
552536005290	phosphorylation loop region [posttranslational modification]
552536005291	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
552536005292	active site
552536005293	catalytic residues [active]
552536005294	metal binding site [ion binding]; metal-binding site
552536005295	Flavin Reductases; Region: FlaRed; cl00801
552536005296	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
552536005297	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
552536005298	ATP binding site [chemical binding]; other site
552536005299	substrate interface [chemical binding]; other site
552536005300	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
552536005301	MPT binding site; other site
552536005302	trimer interface [polypeptide binding]; other site
552536005303	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
552536005304	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552536005305	FeS/SAM binding site; other site
552536005306	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
552536005307	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
552536005308	trimer interface [polypeptide binding]; other site
552536005309	dimer interface [polypeptide binding]; other site
552536005310	putative active site [active]
552536005311	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
552536005312	MoaE interaction surface [polypeptide binding]; other site
552536005313	MoeB interaction surface [polypeptide binding]; other site
552536005314	thiocarboxylated glycine; other site
552536005315	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
552536005316	MoaE homodimer interface [polypeptide binding]; other site
552536005317	MoaD interaction [polypeptide binding]; other site
552536005318	active site residues [active]
552536005319	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
552536005320	Walker A motif; other site
552536005321	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
552536005322	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
552536005323	dimer interface [polypeptide binding]; other site
552536005324	putative functional site; other site
552536005325	putative MPT binding site; other site
552536005326	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
552536005327	PBP superfamily domain; Region: PBP_like_2; cl17296
552536005328	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552536005329	membrane-bound complex binding site; other site
552536005330	hinge residues; other site
552536005331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536005332	dimer interface [polypeptide binding]; other site
552536005333	conserved gate region; other site
552536005334	putative PBP binding loops; other site
552536005335	ABC-ATPase subunit interface; other site
552536005336	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
552536005337	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
552536005338	Walker A/P-loop; other site
552536005339	ATP binding site [chemical binding]; other site
552536005340	Q-loop/lid; other site
552536005341	ABC transporter signature motif; other site
552536005342	Walker B; other site
552536005343	D-loop; other site
552536005344	H-loop/switch region; other site
552536005345	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
552536005346	GTP binding site; other site
552536005347	Uncharacterized integral membrane protein [Function unknown]; Region: COG3739
552536005348	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536005349	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536005350	active site
552536005351	motif I; other site
552536005352	motif II; other site
552536005353	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536005354	hypothetical protein; Provisional; Region: PRK13667
552536005355	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
552536005356	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
552536005357	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
552536005358	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
552536005359	Predicted membrane protein [Function unknown]; Region: COG1289
552536005360	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
552536005361	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
552536005362	TrkA-N domain; Region: TrkA_N; pfam02254
552536005363	TrkA-C domain; Region: TrkA_C; pfam02080
552536005364	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552536005365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536005366	active site
552536005367	phosphorylation site [posttranslational modification]
552536005368	intermolecular recognition site; other site
552536005369	dimerization interface [polypeptide binding]; other site
552536005370	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552536005371	DNA binding residues [nucleotide binding]
552536005372	dimerization interface [polypeptide binding]; other site
552536005373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
552536005374	Histidine kinase; Region: HisKA_3; pfam07730
552536005375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536005376	ATP binding site [chemical binding]; other site
552536005377	Mg2+ binding site [ion binding]; other site
552536005378	G-X-G motif; other site
552536005379	Predicted membrane protein [Function unknown]; Region: COG4758
552536005380	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
552536005381	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
552536005382	S1 domain; Region: S1_2; pfam13509
552536005383	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
552536005384	RNA binding site [nucleotide binding]; other site
552536005385	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
552536005386	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
552536005387	HPr interaction site; other site
552536005388	glycerol kinase (GK) interaction site [polypeptide binding]; other site
552536005389	active site
552536005390	phosphorylation site [posttranslational modification]
552536005391	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
552536005392	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
552536005393	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
552536005394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536005395	dimer interface [polypeptide binding]; other site
552536005396	conserved gate region; other site
552536005397	putative PBP binding loops; other site
552536005398	ABC-ATPase subunit interface; other site
552536005399	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
552536005400	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536005401	Walker A/P-loop; other site
552536005402	ATP binding site [chemical binding]; other site
552536005403	Q-loop/lid; other site
552536005404	ABC transporter signature motif; other site
552536005405	Walker B; other site
552536005406	D-loop; other site
552536005407	H-loop/switch region; other site
552536005408	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
552536005409	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
552536005410	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
552536005411	Mechanosensitive ion channel; Region: MS_channel; pfam00924
552536005412	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
552536005413	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
552536005414	metal binding site [ion binding]; metal-binding site
552536005415	putative dimer interface [polypeptide binding]; other site
552536005416	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
552536005417	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
552536005418	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
552536005419	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
552536005420	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536005421	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536005422	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552536005423	dimerization interface [polypeptide binding]; other site
552536005424	FOG: CBS domain [General function prediction only]; Region: COG0517
552536005425	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
552536005426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
552536005427	aminotransferase A; Validated; Region: PRK07683
552536005428	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536005429	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536005430	homodimer interface [polypeptide binding]; other site
552536005431	catalytic residue [active]
552536005432	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
552536005433	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
552536005434	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
552536005435	Uncharacterized conserved protein [Function unknown]; Region: COG1434
552536005436	putative active site [active]
552536005437	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
552536005438	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
552536005439	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
552536005440	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
552536005441	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
552536005442	dimerization domain swap beta strand [polypeptide binding]; other site
552536005443	regulatory protein interface [polypeptide binding]; other site
552536005444	active site
552536005445	regulatory phosphorylation site [posttranslational modification]; other site
552536005446	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
552536005447	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
552536005448	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552536005449	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
552536005450	nucleotide binding site [chemical binding]; other site
552536005451	CAAX protease self-immunity; Region: Abi; pfam02517
552536005452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536005453	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
552536005454	Walker A motif; other site
552536005455	ATP binding site [chemical binding]; other site
552536005456	Walker B motif; other site
552536005457	arginine finger; other site
552536005458	UvrB/uvrC motif; Region: UVR; pfam02151
552536005459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536005460	Walker A motif; other site
552536005461	ATP binding site [chemical binding]; other site
552536005462	Walker B motif; other site
552536005463	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
552536005464	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
552536005465	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
552536005466	DNA binding site [nucleotide binding]
552536005467	active site
552536005468	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
552536005469	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
552536005470	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
552536005471	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
552536005472	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
552536005473	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
552536005474	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
552536005475	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536005476	MarR family; Region: MarR_2; cl17246
552536005477	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
552536005478	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
552536005479	G1 box; other site
552536005480	putative GEF interaction site [polypeptide binding]; other site
552536005481	GTP/Mg2+ binding site [chemical binding]; other site
552536005482	Switch I region; other site
552536005483	G2 box; other site
552536005484	G3 box; other site
552536005485	Switch II region; other site
552536005486	G4 box; other site
552536005487	G5 box; other site
552536005488	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
552536005489	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
552536005490	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
552536005491	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536005492	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536005493	Walker A/P-loop; other site
552536005494	ATP binding site [chemical binding]; other site
552536005495	Q-loop/lid; other site
552536005496	ABC transporter signature motif; other site
552536005497	Walker B; other site
552536005498	D-loop; other site
552536005499	H-loop/switch region; other site
552536005500	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
552536005501	LytTr DNA-binding domain; Region: LytTR; smart00850
552536005502	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
552536005503	catalytic residues [active]
552536005504	dimer interface [polypeptide binding]; other site
552536005505	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
552536005506	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
552536005507	putative oligomer interface [polypeptide binding]; other site
552536005508	putative active site [active]
552536005509	metal binding site [ion binding]; metal-binding site
552536005510	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005511	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536005512	putative substrate translocation pore; other site
552536005513	ABC-2 type transporter; Region: ABC2_membrane; cl17235
552536005514	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
552536005515	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
552536005516	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536005517	Walker A/P-loop; other site
552536005518	ATP binding site [chemical binding]; other site
552536005519	Q-loop/lid; other site
552536005520	ABC transporter signature motif; other site
552536005521	Walker B; other site
552536005522	D-loop; other site
552536005523	H-loop/switch region; other site
552536005524	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
552536005525	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
552536005526	homodimer interface [polypeptide binding]; other site
552536005527	substrate-cofactor binding pocket; other site
552536005528	catalytic residue [active]
552536005529	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
552536005530	Putative esterase; Region: Esterase; pfam00756
552536005531	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536005532	Coenzyme A binding pocket [chemical binding]; other site
552536005533	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
552536005534	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536005535	active site
552536005536	dimer interface [polypeptide binding]; other site
552536005537	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
552536005538	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
552536005539	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
552536005540	acyl-activating enzyme (AAE) consensus motif; other site
552536005541	AMP binding site [chemical binding]; other site
552536005542	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
552536005543	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
552536005544	DltD N-terminal region; Region: DltD_N; pfam04915
552536005545	DltD central region; Region: DltD_M; pfam04918
552536005546	DltD C-terminal region; Region: DltD_C; pfam04914
552536005547	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
552536005548	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
552536005549	NAD binding site [chemical binding]; other site
552536005550	homotetramer interface [polypeptide binding]; other site
552536005551	homodimer interface [polypeptide binding]; other site
552536005552	substrate binding site [chemical binding]; other site
552536005553	active site
552536005554	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
552536005555	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
552536005556	active site
552536005557	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
552536005558	ATP-NAD kinase; Region: NAD_kinase; pfam01513
552536005559	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
552536005560	synthetase active site [active]
552536005561	NTP binding site [chemical binding]; other site
552536005562	metal binding site [ion binding]; metal-binding site
552536005563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536005564	TPR motif; other site
552536005565	binding surface
552536005566	Tetratricopeptide repeat; Region: TPR_16; pfam13432
552536005567	Tetratrico peptide repeat; Region: TPR_5; pfam12688
552536005568	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
552536005569	putative active site [active]
552536005570	putative metal binding residues [ion binding]; other site
552536005571	signature motif; other site
552536005572	putative triphosphate binding site [ion binding]; other site
552536005573	heat shock protein HtpX; Provisional; Region: PRK04897
552536005574	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
552536005575	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
552536005576	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
552536005577	Peptidase family U32; Region: Peptidase_U32; pfam01136
552536005578	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
552536005579	Peptidase family U32; Region: Peptidase_U32; pfam01136
552536005580	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
552536005581	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
552536005582	Mg++ binding site [ion binding]; other site
552536005583	putative catalytic motif [active]
552536005584	substrate binding site [chemical binding]; other site
552536005585	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536005586	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536005587	DNA-binding site [nucleotide binding]; DNA binding site
552536005588	UTRA domain; Region: UTRA; pfam07702
552536005589	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
552536005590	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
552536005591	active site
552536005592	trimer interface [polypeptide binding]; other site
552536005593	allosteric site; other site
552536005594	active site lid [active]
552536005595	hexamer (dimer of trimers) interface [polypeptide binding]; other site
552536005596	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
552536005597	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
552536005598	active site
552536005599	dimer interface [polypeptide binding]; other site
552536005600	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
552536005601	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
552536005602	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
552536005603	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
552536005604	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
552536005605	PGAP1-like protein; Region: PGAP1; pfam07819
552536005606	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
552536005607	Domain of unknown function DUF20; Region: UPF0118; pfam01594
552536005608	Transcriptional regulators [Transcription]; Region: FadR; COG2186
552536005609	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536005610	DNA-binding site [nucleotide binding]; DNA binding site
552536005611	FCD domain; Region: FCD; pfam07729
552536005612	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
552536005613	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005614	putative substrate translocation pore; other site
552536005615	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
552536005616	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
552536005617	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552536005618	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
552536005619	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
552536005620	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
552536005621	dimerization interface [polypeptide binding]; other site
552536005622	DPS ferroxidase diiron center [ion binding]; other site
552536005623	ion pore; other site
552536005624	HSP90 family protein; Provisional; Region: PRK14083
552536005625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536005626	ATP binding site [chemical binding]; other site
552536005627	Mg2+ binding site [ion binding]; other site
552536005628	G-X-G motif; other site
552536005629	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
552536005630	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
552536005631	Low molecular weight phosphatase family; Region: LMWPc; cd00115
552536005632	active site
552536005633	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
552536005634	dimer interface [polypeptide binding]; other site
552536005635	FMN binding site [chemical binding]; other site
552536005636	NADPH bind site [chemical binding]; other site
552536005637	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
552536005638	epoxyqueuosine reductase; Region: TIGR00276
552536005639	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
552536005640	A new structural DNA glycosylase; Region: AlkD_like; cl11434
552536005641	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
552536005642	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
552536005643	Uncharacterized conserved protein [Function unknown]; Region: COG0398
552536005644	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
552536005645	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
552536005646	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
552536005647	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
552536005648	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
552536005649	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
552536005650	active site
552536005651	catalytic site [active]
552536005652	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
552536005653	active site
552536005654	DNA binding site [nucleotide binding]
552536005655	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
552536005656	Domain of unknown function (DUF373); Region: DUF373; cl12079
552536005657	Sulfatase; Region: Sulfatase; pfam00884
552536005658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536005659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536005660	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
552536005661	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
552536005662	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
552536005663	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552536005664	Walker A/P-loop; other site
552536005665	ATP binding site [chemical binding]; other site
552536005666	Q-loop/lid; other site
552536005667	ABC transporter signature motif; other site
552536005668	Walker B; other site
552536005669	D-loop; other site
552536005670	H-loop/switch region; other site
552536005671	pantothenate kinase; Provisional; Region: PRK05439
552536005672	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
552536005673	ATP-binding site [chemical binding]; other site
552536005674	CoA-binding site [chemical binding]; other site
552536005675	Mg2+-binding site [ion binding]; other site
552536005676	Predicted membrane protein [Function unknown]; Region: COG3689
552536005677	Predicted permeases [General function prediction only]; Region: COG0701
552536005678	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536005679	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
552536005680	ABC transporter; Region: ABC_tran_2; pfam12848
552536005681	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536005682	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
552536005683	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536005684	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536005685	PRD domain; Region: PRD; pfam00874
552536005686	PRD domain; Region: PRD; pfam00874
552536005687	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536005688	active site
552536005689	phosphorylation site [posttranslational modification]
552536005690	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536005691	beta-galactosidase; Region: BGL; TIGR03356
552536005692	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536005693	methionine cluster; other site
552536005694	active site
552536005695	phosphorylation site [posttranslational modification]
552536005696	metal binding site [ion binding]; metal-binding site
552536005697	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536005698	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536005699	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
552536005700	active site
552536005701	P-loop; other site
552536005702	phosphorylation site [posttranslational modification]
552536005703	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
552536005704	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
552536005705	tetramerization interface [polypeptide binding]; other site
552536005706	NAD(P) binding site [chemical binding]; other site
552536005707	catalytic residues [active]
552536005708	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
552536005709	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
552536005710	Predicted membrane protein [General function prediction only]; Region: COG4194
552536005711	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
552536005712	Predicted transcriptional regulators [Transcription]; Region: COG1725
552536005713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536005714	DNA-binding site [nucleotide binding]; DNA binding site
552536005715	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
552536005716	Domain of unknown function DUF20; Region: UPF0118; pfam01594
552536005717	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536005718	catalytic core [active]
552536005719	glutathione reductase; Validated; Region: PRK06116
552536005720	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552536005721	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536005722	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
552536005723	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
552536005724	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
552536005725	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
552536005726	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536005727	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536005728	DNA-binding site [nucleotide binding]; DNA binding site
552536005729	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
552536005730	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536005731	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536005732	Uncharacterized conserved protein [Function unknown]; Region: COG5646
552536005733	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
552536005734	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
552536005735	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
552536005736	hypothetical protein; Provisional; Region: PRK04351
552536005737	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
552536005738	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
552536005739	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
552536005740	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
552536005741	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
552536005742	RNA binding site [nucleotide binding]; other site
552536005743	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
552536005744	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
552536005745	Sulfate transporter family; Region: Sulfate_transp; pfam00916
552536005746	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
552536005747	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
552536005748	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
552536005749	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552536005750	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
552536005751	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
552536005752	DNA binding residues [nucleotide binding]
552536005753	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
552536005754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536005755	ATP binding site [chemical binding]; other site
552536005756	Mg2+ binding site [ion binding]; other site
552536005757	G-X-G motif; other site
552536005758	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
552536005759	anti sigma factor interaction site; other site
552536005760	regulatory phosphorylation site [posttranslational modification]; other site
552536005761	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
552536005762	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
552536005763	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
552536005764	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
552536005765	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
552536005766	ATP binding site [chemical binding]; other site
552536005767	Mg2+ binding site [ion binding]; other site
552536005768	G-X-G motif; other site
552536005769	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536005770	Rsbr N terminal; Region: Rsbr_N; pfam08678
552536005771	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536005772	PemK-like protein; Region: PemK; pfam02452
552536005773	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
552536005774	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
552536005775	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
552536005776	active site
552536005777	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552536005778	dimer interface [polypeptide binding]; other site
552536005779	substrate binding site [chemical binding]; other site
552536005780	catalytic residues [active]
552536005781	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
552536005782	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
552536005783	Predicted membrane protein [Function unknown]; Region: COG3428
552536005784	Bacterial PH domain; Region: DUF304; pfam03703
552536005785	Bacterial PH domain; Region: DUF304; pfam03703
552536005786	Bacterial PH domain; Region: DUF304; pfam03703
552536005787	Uncharacterized conserved protein [Function unknown]; Region: COG3402
552536005788	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
552536005789	Collagen binding domain; Region: Collagen_bind; pfam05737
552536005790	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
552536005791	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536005792	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
552536005793	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536005794	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536005795	active site
552536005796	catalytic tetrad [active]
552536005797	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
552536005798	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
552536005799	active site
552536005800	trimer interface [polypeptide binding]; other site
552536005801	allosteric site; other site
552536005802	active site lid [active]
552536005803	hexamer (dimer of trimers) interface [polypeptide binding]; other site
552536005804	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536005805	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536005806	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536005807	active site
552536005808	P-loop; other site
552536005809	phosphorylation site [posttranslational modification]
552536005810	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536005811	methionine cluster; other site
552536005812	active site
552536005813	phosphorylation site [posttranslational modification]
552536005814	metal binding site [ion binding]; metal-binding site
552536005815	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536005816	PRD domain; Region: PRD; pfam00874
552536005817	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536005818	active site
552536005819	P-loop; other site
552536005820	phosphorylation site [posttranslational modification]
552536005821	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536005822	active site
552536005823	phosphorylation site [posttranslational modification]
552536005824	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
552536005825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005826	putative substrate translocation pore; other site
552536005827	Predicted transcriptional regulators [Transcription]; Region: COG1733
552536005828	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
552536005829	The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424
552536005830	Domain of unknown function (DUF4176); Region: DUF4176; cl01867
552536005831	Predicted membrane protein [Function unknown]; Region: COG4708
552536005832	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
552536005833	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552536005834	ATP binding site [chemical binding]; other site
552536005835	Mg++ binding site [ion binding]; other site
552536005836	motif III; other site
552536005837	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536005838	nucleotide binding region [chemical binding]; other site
552536005839	ATP-binding site [chemical binding]; other site
552536005840	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
552536005841	active site
552536005842	substrate binding site [chemical binding]; other site
552536005843	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
552536005844	metal binding site [ion binding]; metal-binding site
552536005845	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
552536005846	active site
552536005847	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
552536005848	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
552536005849	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
552536005850	Ca binding site [ion binding]; other site
552536005851	active site
552536005852	catalytic site [active]
552536005853	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536005854	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536005855	dimer interface [polypeptide binding]; other site
552536005856	conserved gate region; other site
552536005857	ABC-ATPase subunit interface; other site
552536005858	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536005859	dimer interface [polypeptide binding]; other site
552536005860	conserved gate region; other site
552536005861	putative PBP binding loops; other site
552536005862	ABC-ATPase subunit interface; other site
552536005863	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
552536005864	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536005865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536005866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536005867	DNA binding site [nucleotide binding]
552536005868	domain linker motif; other site
552536005869	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
552536005870	putative dimerization interface [polypeptide binding]; other site
552536005871	putative ligand binding site [chemical binding]; other site
552536005872	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
552536005873	Esterase/lipase [General function prediction only]; Region: COG1647
552536005874	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
552536005875	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552536005876	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552536005877	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
552536005878	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
552536005879	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
552536005880	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
552536005881	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
552536005882	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536005883	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536005884	amidase; Provisional; Region: PRK11910
552536005885	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552536005886	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
552536005887	Walker A/P-loop; other site
552536005888	ATP binding site [chemical binding]; other site
552536005889	Q-loop/lid; other site
552536005890	ABC transporter signature motif; other site
552536005891	Walker B; other site
552536005892	D-loop; other site
552536005893	H-loop/switch region; other site
552536005894	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552536005895	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552536005896	substrate binding pocket [chemical binding]; other site
552536005897	membrane-bound complex binding site; other site
552536005898	hinge residues; other site
552536005899	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552536005900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536005901	dimer interface [polypeptide binding]; other site
552536005902	conserved gate region; other site
552536005903	putative PBP binding loops; other site
552536005904	ABC-ATPase subunit interface; other site
552536005905	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
552536005906	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
552536005907	GIY-YIG motif/motif A; other site
552536005908	active site
552536005909	catalytic site [active]
552536005910	putative DNA binding site [nucleotide binding]; other site
552536005911	metal binding site [ion binding]; metal-binding site
552536005912	UvrB/uvrC motif; Region: UVR; pfam02151
552536005913	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
552536005914	substrate binding site [chemical binding]; other site
552536005915	zinc-binding site [ion binding]; other site
552536005916	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
552536005917	homotrimer interaction site [polypeptide binding]; other site
552536005918	putative active site [active]
552536005919	Predicted membrane protein [Function unknown]; Region: COG3326
552536005920	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
552536005921	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
552536005922	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536005923	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
552536005924	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536005925	motif II; other site
552536005926	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
552536005927	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536005928	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536005929	putative DNA binding site [nucleotide binding]; other site
552536005930	putative Zn2+ binding site [ion binding]; other site
552536005931	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005932	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536005933	putative substrate translocation pore; other site
552536005934	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
552536005935	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005936	putative substrate translocation pore; other site
552536005937	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536005938	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536005939	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
552536005940	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
552536005941	Walker A/P-loop; other site
552536005942	ATP binding site [chemical binding]; other site
552536005943	Q-loop/lid; other site
552536005944	ABC transporter signature motif; other site
552536005945	Walker B; other site
552536005946	D-loop; other site
552536005947	H-loop/switch region; other site
552536005948	Predicted membrane protein [Function unknown]; Region: COG3223
552536005949	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536005950	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536005951	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536005952	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536005953	non-specific DNA binding site [nucleotide binding]; other site
552536005954	salt bridge; other site
552536005955	sequence-specific DNA binding site [nucleotide binding]; other site
552536005956	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
552536005957	Transposase; Region: HTH_Tnp_1; pfam01527
552536005958	Predicted permeases [General function prediction only]; Region: COG0679
552536005959	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
552536005960	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
552536005961	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
552536005962	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
552536005963	dimer interface [polypeptide binding]; other site
552536005964	PYR/PP interface [polypeptide binding]; other site
552536005965	TPP binding site [chemical binding]; other site
552536005966	substrate binding site [chemical binding]; other site
552536005967	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
552536005968	Domain of unknown function; Region: EKR; smart00890
552536005969	4Fe-4S binding domain; Region: Fer4_6; pfam12837
552536005970	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
552536005971	TPP-binding site [chemical binding]; other site
552536005972	dimer interface [polypeptide binding]; other site
552536005973	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
552536005974	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
552536005975	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
552536005976	PhoU domain; Region: PhoU; pfam01895
552536005977	PhoU domain; Region: PhoU; pfam01895
552536005978	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
552536005979	homodimer interface [polypeptide binding]; other site
552536005980	catalytic residues [active]
552536005981	NAD binding site [chemical binding]; other site
552536005982	substrate binding pocket [chemical binding]; other site
552536005983	flexible flap; other site
552536005984	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
552536005985	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536005986	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536005987	active site
552536005988	catalytic tetrad [active]
552536005989	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536005990	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536005991	DNA binding residues [nucleotide binding]
552536005992	putative dimer interface [polypeptide binding]; other site
552536005993	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
552536005994	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552536005995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536005996	Coenzyme A binding pocket [chemical binding]; other site
552536005997	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
552536005998	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
552536005999	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536006000	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
552536006001	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536006002	motif II; other site
552536006003	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
552536006004	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
552536006005	dimer interface [polypeptide binding]; other site
552536006006	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536006007	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
552536006008	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
552536006009	FMN binding site [chemical binding]; other site
552536006010	substrate binding site [chemical binding]; other site
552536006011	putative catalytic residue [active]
552536006012	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536006013	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536006014	nucleotide binding site [chemical binding]; other site
552536006015	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
552536006016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536006017	Zn2+ binding site [ion binding]; other site
552536006018	Mg2+ binding site [ion binding]; other site
552536006019	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
552536006020	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
552536006021	active site
552536006022	zinc binding site [ion binding]; other site
552536006023	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536006024	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536006025	DNA binding residues [nucleotide binding]
552536006026	putative dimer interface [polypeptide binding]; other site
552536006027	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
552536006028	classical (c) SDRs; Region: SDR_c; cd05233
552536006029	NAD(P) binding site [chemical binding]; other site
552536006030	active site
552536006031	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536006032	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536006033	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536006034	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536006035	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
552536006036	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
552536006037	catalytic residues [active]
552536006038	catalytic nucleophile [active]
552536006039	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
552536006040	Resolvase, N terminal domain; Region: Resolvase; pfam00239
552536006041	Helix-turn-helix domain; Region: HTH_28; pfam13518
552536006042	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536006043	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
552536006044	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
552536006045	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
552536006046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536006047	dimer interface [polypeptide binding]; other site
552536006048	conserved gate region; other site
552536006049	putative PBP binding loops; other site
552536006050	ABC-ATPase subunit interface; other site
552536006051	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
552536006052	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536006053	putative PBP binding loops; other site
552536006054	ABC-ATPase subunit interface; other site
552536006055	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
552536006056	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
552536006057	Walker A/P-loop; other site
552536006058	ATP binding site [chemical binding]; other site
552536006059	Q-loop/lid; other site
552536006060	ABC transporter signature motif; other site
552536006061	Walker B; other site
552536006062	D-loop; other site
552536006063	H-loop/switch region; other site
552536006064	TOBE domain; Region: TOBE_2; pfam08402
552536006065	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536006066	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536006067	non-specific DNA binding site [nucleotide binding]; other site
552536006068	salt bridge; other site
552536006069	sequence-specific DNA binding site [nucleotide binding]; other site
552536006070	Cupin domain; Region: Cupin_2; pfam07883
552536006071	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
552536006072	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
552536006073	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
552536006074	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
552536006075	synthetase active site [active]
552536006076	NTP binding site [chemical binding]; other site
552536006077	metal binding site [ion binding]; metal-binding site
552536006078	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
552536006079	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
552536006080	PAS domain; Region: PAS_9; pfam13426
552536006081	putative active site [active]
552536006082	heme pocket [chemical binding]; other site
552536006083	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536006084	lysine transporter; Provisional; Region: PRK10836
552536006085	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552536006086	MarR family; Region: MarR_2; pfam12802
552536006087	Uncharacterized conserved protein [Function unknown]; Region: COG2353
552536006088	Predicted permeases [General function prediction only]; Region: RarD; COG2962
552536006089	EamA-like transporter family; Region: EamA; pfam00892
552536006090	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
552536006091	NADH(P)-binding; Region: NAD_binding_10; pfam13460
552536006092	NAD binding site [chemical binding]; other site
552536006093	substrate binding site [chemical binding]; other site
552536006094	putative active site [active]
552536006095	Protein of unknown function (DUF554); Region: DUF554; pfam04474
552536006096	Predicted amidohydrolase [General function prediction only]; Region: COG0388
552536006097	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
552536006098	active site
552536006099	catalytic triad [active]
552536006100	dimer interface [polypeptide binding]; other site
552536006101	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
552536006102	putative deacylase active site [active]
552536006103	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
552536006104	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
552536006105	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
552536006106	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
552536006107	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
552536006108	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
552536006109	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
552536006110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
552536006111	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
552536006112	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
552536006113	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552536006114	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
552536006115	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536006116	Walker A motif; other site
552536006117	ATP binding site [chemical binding]; other site
552536006118	Walker B motif; other site
552536006119	arginine finger; other site
552536006120	Transcriptional antiterminator [Transcription]; Region: COG3933
552536006121	PRD domain; Region: PRD; pfam00874
552536006122	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536006123	active pocket/dimerization site; other site
552536006124	active site
552536006125	phosphorylation site [posttranslational modification]
552536006126	PRD domain; Region: PRD; pfam00874
552536006127	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536006128	active pocket/dimerization site; other site
552536006129	active site
552536006130	phosphorylation site [posttranslational modification]
552536006131	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
552536006132	active site
552536006133	phosphorylation site [posttranslational modification]
552536006134	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
552536006135	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
552536006136	Predicted membrane protein [Function unknown]; Region: COG4811
552536006137	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536006138	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536006139	nucleotide binding site [chemical binding]; other site
552536006140	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
552536006141	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
552536006142	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
552536006143	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
552536006144	putative NADP binding site [chemical binding]; other site
552536006145	putative dimer interface [polypeptide binding]; other site
552536006146	Transcriptional regulators [Transcription]; Region: GntR; COG1802
552536006147	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536006148	DNA-binding site [nucleotide binding]; DNA binding site
552536006149	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
552536006150	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
552536006151	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
552536006152	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
552536006153	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
552536006154	putative active site [active]
552536006155	putative metal binding site [ion binding]; other site
552536006156	GTPases [General function prediction only]; Region: HflX; COG2262
552536006157	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
552536006158	HflX GTPase family; Region: HflX; cd01878
552536006159	G1 box; other site
552536006160	GTP/Mg2+ binding site [chemical binding]; other site
552536006161	Switch I region; other site
552536006162	G2 box; other site
552536006163	G3 box; other site
552536006164	Switch II region; other site
552536006165	G4 box; other site
552536006166	G5 box; other site
552536006167	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
552536006168	Predicted esterase [General function prediction only]; Region: COG0400
552536006169	putative hydrolase; Provisional; Region: PRK11460
552536006170	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
552536006171	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536006172	Zn binding site [ion binding]; other site
552536006173	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
552536006174	Zn binding site [ion binding]; other site
552536006175	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
552536006176	Zn binding site [ion binding]; other site
552536006177	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
552536006178	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536006179	Zn binding site [ion binding]; other site
552536006180	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
552536006181	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552536006182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536006183	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536006184	Walker A/P-loop; other site
552536006185	ATP binding site [chemical binding]; other site
552536006186	Q-loop/lid; other site
552536006187	ABC transporter signature motif; other site
552536006188	Walker B; other site
552536006189	D-loop; other site
552536006190	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552536006191	H-loop/switch region; other site
552536006192	active site
552536006193	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
552536006194	active site
552536006195	catalytic triad [active]
552536006196	oxyanion hole [active]
552536006197	SnoaL-like domain; Region: SnoaL_4; pfam13577
552536006198	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536006199	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
552536006200	ligand binding site [chemical binding]; other site
552536006201	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
552536006202	non-specific DNA interactions [nucleotide binding]; other site
552536006203	DNA binding site [nucleotide binding]
552536006204	sequence specific DNA binding site [nucleotide binding]; other site
552536006205	putative cAMP binding site [chemical binding]; other site
552536006206	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
552536006207	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536006208	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536006209	non-specific DNA binding site [nucleotide binding]; other site
552536006210	salt bridge; other site
552536006211	sequence-specific DNA binding site [nucleotide binding]; other site
552536006212	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536006213	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
552536006214	Walker A/P-loop; other site
552536006215	ATP binding site [chemical binding]; other site
552536006216	Q-loop/lid; other site
552536006217	ABC transporter signature motif; other site
552536006218	Walker B; other site
552536006219	D-loop; other site
552536006220	H-loop/switch region; other site
552536006221	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536006222	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552536006223	FtsX-like permease family; Region: FtsX; pfam02687
552536006224	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552536006225	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536006226	Walker A/P-loop; other site
552536006227	ATP binding site [chemical binding]; other site
552536006228	Q-loop/lid; other site
552536006229	ABC transporter signature motif; other site
552536006230	Walker B; other site
552536006231	D-loop; other site
552536006232	H-loop/switch region; other site
552536006233	Predicted transcriptional regulators [Transcription]; Region: COG1725
552536006234	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536006235	DNA-binding site [nucleotide binding]; DNA binding site
552536006236	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536006237	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
552536006238	ligand binding site [chemical binding]; other site
552536006239	flexible hinge region; other site
552536006240	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536006241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536006242	non-specific DNA binding site [nucleotide binding]; other site
552536006243	salt bridge; other site
552536006244	sequence-specific DNA binding site [nucleotide binding]; other site
552536006245	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006246	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006247	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536006248	Leucine rich repeat; Region: LRR_8; pfam13855
552536006249	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006250	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006251	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006252	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
552536006253	GIY-YIG motif/motif A; other site
552536006254	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
552536006255	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
552536006256	active site
552536006257	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
552536006258	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
552536006259	glutaminase active site [active]
552536006260	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
552536006261	dimer interface [polypeptide binding]; other site
552536006262	active site
552536006263	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
552536006264	dimer interface [polypeptide binding]; other site
552536006265	active site
552536006266	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
552536006267	putative active site [active]
552536006268	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536006269	dimerization interface [polypeptide binding]; other site
552536006270	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
552536006271	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
552536006272	dimer interface [polypeptide binding]; other site
552536006273	putative CheW interface [polypeptide binding]; other site
552536006274	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
552536006275	pyruvate oxidase; Provisional; Region: PRK08611
552536006276	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
552536006277	PYR/PP interface [polypeptide binding]; other site
552536006278	dimer interface [polypeptide binding]; other site
552536006279	tetramer interface [polypeptide binding]; other site
552536006280	TPP binding site [chemical binding]; other site
552536006281	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552536006282	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
552536006283	TPP-binding site [chemical binding]; other site
552536006284	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
552536006285	Protein of unknown function (DUF1048); Region: DUF1048; cl01986
552536006286	Predicted transcriptional regulators [Transcription]; Region: COG1695
552536006287	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
552536006288	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
552536006289	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
552536006290	N-acetyl-D-glucosamine binding site [chemical binding]; other site
552536006291	catalytic residue [active]
552536006292	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
552536006293	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552536006294	Walker A motif; other site
552536006295	ATP binding site [chemical binding]; other site
552536006296	Walker B motif; other site
552536006297	flagellar assembly protein H; Validated; Region: fliH; PRK06800
552536006298	Flagellar assembly protein FliH; Region: FliH; pfam02108
552536006299	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
552536006300	FliG C-terminal domain; Region: FliG_C; pfam01706
552536006301	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
552536006302	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
552536006303	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
552536006304	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
552536006305	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
552536006306	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
552536006307	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
552536006308	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
552536006309	flagellar capping protein; Validated; Region: fliD; PRK06798
552536006310	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
552536006311	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
552536006312	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
552536006313	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
552536006314	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
552536006315	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
552536006316	Protein of unknown function (DUF327); Region: DUF327; pfam03885
552536006317	flagellar motor switch protein; Reviewed; Region: PRK06782
552536006318	CheC-like family; Region: CheC; pfam04509
552536006319	CheC-like family; Region: CheC; pfam04509
552536006320	Chemotaxis phosphatase CheX; Region: CheX; cl15816
552536006321	CheC-like family; Region: CheC; pfam04509
552536006322	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
552536006323	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
552536006324	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
552536006325	flagellar motor switch protein; Validated; Region: PRK06789
552536006326	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
552536006327	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
552536006328	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
552536006329	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
552536006330	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
552536006331	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
552536006332	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
552536006333	flagellar motor switch protein; Validated; Region: PRK06788
552536006334	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
552536006335	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
552536006336	putative binding surface; other site
552536006337	active site
552536006338	P2 response regulator binding domain; Region: P2; pfam07194
552536006339	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
552536006340	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536006341	ATP binding site [chemical binding]; other site
552536006342	Mg2+ binding site [ion binding]; other site
552536006343	G-X-G motif; other site
552536006344	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
552536006345	Response regulator receiver domain; Region: Response_reg; pfam00072
552536006346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536006347	active site
552536006348	phosphorylation site [posttranslational modification]
552536006349	intermolecular recognition site; other site
552536006350	dimerization interface [polypeptide binding]; other site
552536006351	flagellin; Provisional; Region: PRK12805
552536006352	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
552536006353	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
552536006354	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
552536006355	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
552536006356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536006357	active site
552536006358	phosphorylation site [posttranslational modification]
552536006359	intermolecular recognition site; other site
552536006360	dimerization interface [polypeptide binding]; other site
552536006361	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
552536006362	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
552536006363	putative metal binding site; other site
552536006364	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552536006365	binding surface
552536006366	TPR motif; other site
552536006367	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
552536006368	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
552536006369	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
552536006370	ligand binding site [chemical binding]; other site
552536006371	flagellar motor protein MotA; Validated; Region: PRK08124
552536006372	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
552536006373	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
552536006374	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
552536006375	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
552536006376	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
552536006377	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
552536006378	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
552536006379	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
552536006380	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552536006381	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
552536006382	FHIPEP family; Region: FHIPEP; pfam00771
552536006383	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
552536006384	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
552536006385	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
552536006386	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
552536006387	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
552536006388	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
552536006389	Predicted membrane protein [Function unknown]; Region: COG3152
552536006390	Protein of unknown function (DUF805); Region: DUF805; pfam05656
552536006391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
552536006392	oxidoreductase; Provisional; Region: PRK07985
552536006393	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552536006394	NAD(P) binding site [chemical binding]; other site
552536006395	active site
552536006396	inner membrane transport permease; Provisional; Region: PRK15066
552536006397	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
552536006398	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552536006399	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
552536006400	Walker A/P-loop; other site
552536006401	ATP binding site [chemical binding]; other site
552536006402	Q-loop/lid; other site
552536006403	ABC transporter signature motif; other site
552536006404	Walker B; other site
552536006405	D-loop; other site
552536006406	H-loop/switch region; other site
552536006407	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
552536006408	maltose O-acetyltransferase; Provisional; Region: PRK10092
552536006409	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
552536006410	active site
552536006411	substrate binding site [chemical binding]; other site
552536006412	trimer interface [polypeptide binding]; other site
552536006413	CoA binding site [chemical binding]; other site
552536006414	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536006415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536006416	active site
552536006417	motif I; other site
552536006418	motif II; other site
552536006419	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536006420	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536006421	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
552536006422	dimer interface [polypeptide binding]; other site
552536006423	substrate binding site [chemical binding]; other site
552536006424	ATP binding site [chemical binding]; other site
552536006425	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
552536006426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
552536006427	Transposase; Region: HTH_Tnp_1; cl17663
552536006428	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536006429	non-specific DNA binding site [nucleotide binding]; other site
552536006430	salt bridge; other site
552536006431	sequence-specific DNA binding site [nucleotide binding]; other site
552536006432	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
552536006433	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
552536006434	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
552536006435	minor groove reading motif; other site
552536006436	helix-hairpin-helix signature motif; other site
552536006437	substrate binding pocket [chemical binding]; other site
552536006438	active site
552536006439	Predicted membrane protein [Function unknown]; Region: COG2322
552536006440	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
552536006441	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
552536006442	active site
552536006443	metal binding site [ion binding]; metal-binding site
552536006444	Predicted integral membrane protein [Function unknown]; Region: COG5523
552536006445	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552536006446	Transcriptional regulators [Transcription]; Region: GntR; COG1802
552536006447	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536006448	DNA-binding site [nucleotide binding]; DNA binding site
552536006449	Predicted membrane protein [Function unknown]; Region: COG1511
552536006450	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
552536006451	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536006452	Transcriptional regulators [Transcription]; Region: GntR; COG1802
552536006453	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536006454	DNA-binding site [nucleotide binding]; DNA binding site
552536006455	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
552536006456	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
552536006457	Cl binding site [ion binding]; other site
552536006458	oligomer interface [polypeptide binding]; other site
552536006459	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
552536006460	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
552536006461	putative metal binding site [ion binding]; other site
552536006462	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
552536006463	active site
552536006464	amino acid transporter; Region: 2A0306; TIGR00909
552536006465	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
552536006466	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
552536006467	Sulfatase; Region: Sulfatase; pfam00884
552536006468	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
552536006469	catalytic residue [active]
552536006470	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
552536006471	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536006472	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536006473	motif II; other site
552536006474	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536006475	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536006476	active site
552536006477	catalytic tetrad [active]
552536006478	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
552536006479	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552536006480	Domain of unknown function (DUF1768); Region: DUF1768; cl01271
552536006481	Methyltransferase domain; Region: Methyltransf_31; pfam13847
552536006482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536006483	S-adenosylmethionine binding site [chemical binding]; other site
552536006484	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
552536006485	Predicted transcriptional regulator [Transcription]; Region: COG1959
552536006486	Transcriptional regulator; Region: Rrf2; pfam02082
552536006487	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
552536006488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536006489	motif II; other site
552536006490	Isochorismatase family; Region: Isochorismatase; pfam00857
552536006491	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
552536006492	catalytic triad [active]
552536006493	conserved cis-peptide bond; other site
552536006494	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
552536006495	domain interaction interfaces [polypeptide binding]; other site
552536006496	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
552536006497	domain interaction interfaces [polypeptide binding]; other site
552536006498	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
552536006499	domain interaction interfaces [polypeptide binding]; other site
552536006500	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
552536006501	domain interaction interfaces [polypeptide binding]; other site
552536006502	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
552536006503	active site
552536006504	catalytic triad [active]
552536006505	oxyanion hole [active]
552536006506	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552536006507	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536006508	Coenzyme A binding pocket [chemical binding]; other site
552536006509	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
552536006510	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
552536006511	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
552536006512	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552536006513	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552536006514	active site
552536006515	ATP binding site [chemical binding]; other site
552536006516	substrate binding site [chemical binding]; other site
552536006517	activation loop (A-loop); other site
552536006518	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
552536006519	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
552536006520	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
552536006521	putative active site [active]
552536006522	catalytic site [active]
552536006523	putative metal binding site [ion binding]; other site
552536006524	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
552536006525	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
552536006526	putative NAD(P) binding site [chemical binding]; other site
552536006527	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552536006528	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536006529	putative DNA binding site [nucleotide binding]; other site
552536006530	putative Zn2+ binding site [ion binding]; other site
552536006531	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
552536006532	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552536006533	Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308
552536006534	Leucine rich repeat; Region: LRR_8; pfam13855
552536006535	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006536	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
552536006537	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
552536006538	active site residue [active]
552536006539	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536006540	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536006541	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
552536006542	Walker A/P-loop; other site
552536006543	ATP binding site [chemical binding]; other site
552536006544	Q-loop/lid; other site
552536006545	ABC transporter signature motif; other site
552536006546	Walker B; other site
552536006547	D-loop; other site
552536006548	H-loop/switch region; other site
552536006549	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536006550	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536006551	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536006552	Walker A/P-loop; other site
552536006553	ATP binding site [chemical binding]; other site
552536006554	Q-loop/lid; other site
552536006555	ABC transporter signature motif; other site
552536006556	Walker B; other site
552536006557	D-loop; other site
552536006558	H-loop/switch region; other site
552536006559	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552536006560	MarR family; Region: MarR_2; pfam12802
552536006561	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
552536006562	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
552536006563	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
552536006564	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536006565	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
552536006566	Coenzyme A binding pocket [chemical binding]; other site
552536006567	Uncharacterized conserved protein [Function unknown]; Region: COG3595
552536006568	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
552536006569	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
552536006570	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
552536006571	Predicted membrane protein [Function unknown]; Region: COG4709
552536006572	Predicted transcriptional regulators [Transcription]; Region: COG1695
552536006573	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
552536006574	BioY family; Region: BioY; pfam02632
552536006575	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536006576	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
552536006577	ligand binding site [chemical binding]; other site
552536006578	flexible hinge region; other site
552536006579	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
552536006580	non-specific DNA interactions [nucleotide binding]; other site
552536006581	DNA binding site [nucleotide binding]
552536006582	sequence specific DNA binding site [nucleotide binding]; other site
552536006583	putative cAMP binding site [chemical binding]; other site
552536006584	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
552536006585	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
552536006586	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
552536006587	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552536006588	homodimer interface [polypeptide binding]; other site
552536006589	substrate-cofactor binding pocket; other site
552536006590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536006591	catalytic residue [active]
552536006592	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
552536006593	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
552536006594	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
552536006595	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
552536006596	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
552536006597	DAK2 domain; Region: Dak2; pfam02734
552536006598	EDD domain protein, DegV family; Region: DegV; TIGR00762
552536006599	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
552536006600	Predicted membrane protein [Function unknown]; Region: COG4852
552536006601	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
552536006602	DNA photolyase; Region: DNA_photolyase; pfam00875
552536006603	UreD urease accessory protein; Region: UreD; cl00530
552536006604	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
552536006605	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
552536006606	WxL domain surface cell wall-binding; Region: WxL; pfam13731
552536006607	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
552536006608	Domain of unknown function DUF20; Region: UPF0118; pfam01594
552536006609	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
552536006610	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536006611	ATP binding site [chemical binding]; other site
552536006612	putative Mg++ binding site [ion binding]; other site
552536006613	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
552536006614	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
552536006615	nucleotide binding region [chemical binding]; other site
552536006616	ATP-binding site [chemical binding]; other site
552536006617	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
552536006618	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536006619	Bacterial SH3 domain; Region: SH3_3; pfam08239
552536006620	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536006621	NlpC/P60 family; Region: NLPC_P60; pfam00877
552536006622	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
552536006623	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
552536006624	putative RNA binding site [nucleotide binding]; other site
552536006625	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536006626	S-adenosylmethionine binding site [chemical binding]; other site
552536006627	Predicted esterase [General function prediction only]; Region: COG0400
552536006628	putative hydrolase; Provisional; Region: PRK11460
552536006629	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
552536006630	Uncharacterized conserved protein [Function unknown]; Region: COG2966
552536006631	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
552536006632	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
552536006633	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
552536006634	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006635	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536006636	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536006637	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536006638	DNA-binding site [nucleotide binding]; DNA binding site
552536006639	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
552536006640	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536006641	beta-galactosidase; Region: BGL; TIGR03356
552536006642	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
552536006643	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
552536006644	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
552536006645	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
552536006646	DNA binding site [nucleotide binding]
552536006647	active site
552536006648	histidinol-phosphatase; Reviewed; Region: PRK08123
552536006649	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
552536006650	active site
552536006651	dimer interface [polypeptide binding]; other site
552536006652	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
552536006653	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
552536006654	dimer interface [polypeptide binding]; other site
552536006655	motif 1; other site
552536006656	active site
552536006657	motif 2; other site
552536006658	motif 3; other site
552536006659	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
552536006660	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
552536006661	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
552536006662	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
552536006663	NAD binding site [chemical binding]; other site
552536006664	dimerization interface [polypeptide binding]; other site
552536006665	product binding site; other site
552536006666	substrate binding site [chemical binding]; other site
552536006667	zinc binding site [ion binding]; other site
552536006668	catalytic residues [active]
552536006669	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
552536006670	putative active site pocket [active]
552536006671	4-fold oligomerization interface [polypeptide binding]; other site
552536006672	metal binding residues [ion binding]; metal-binding site
552536006673	3-fold/trimer interface [polypeptide binding]; other site
552536006674	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
552536006675	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
552536006676	putative active site [active]
552536006677	oxyanion strand; other site
552536006678	catalytic triad [active]
552536006679	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
552536006680	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
552536006681	catalytic residues [active]
552536006682	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
552536006683	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
552536006684	substrate binding site [chemical binding]; other site
552536006685	glutamase interaction surface [polypeptide binding]; other site
552536006686	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
552536006687	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
552536006688	metal binding site [ion binding]; metal-binding site
552536006689	glutamate dehydrogenase; Provisional; Region: PRK09414
552536006690	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
552536006691	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
552536006692	NAD(P) binding site [chemical binding]; other site
552536006693	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
552536006694	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
552536006695	Cl binding site [ion binding]; other site
552536006696	oligomer interface [polypeptide binding]; other site
552536006697	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
552536006698	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006699	catalytic core [active]
552536006700	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006701	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006702	catalytic core [active]
552536006703	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006704	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
552536006705	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536006706	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
552536006707	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
552536006708	dimer interface [polypeptide binding]; other site
552536006709	active site
552536006710	metal binding site [ion binding]; metal-binding site
552536006711	FOG: CBS domain [General function prediction only]; Region: COG0517
552536006712	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
552536006713	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
552536006714	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
552536006715	WxL domain surface cell wall-binding; Region: WxL; pfam13731
552536006716	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536006717	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536006718	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006719	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006720	WxL domain surface cell wall-binding; Region: WxL; pfam13731
552536006721	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536006722	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536006723	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
552536006724	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
552536006725	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
552536006726	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536006727	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
552536006728	Glucitol operon activator protein (GutM); Region: GutM; cl01890
552536006729	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
552536006730	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
552536006731	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
552536006732	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
552536006733	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
552536006734	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
552536006735	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
552536006736	intersubunit interface [polypeptide binding]; other site
552536006737	Beta-lactamase; Region: Beta-lactamase; pfam00144
552536006738	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
552536006739	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
552536006740	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
552536006741	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
552536006742	metal binding site [ion binding]; metal-binding site
552536006743	putative dimer interface [polypeptide binding]; other site
552536006744	allantoate amidohydrolase; Reviewed; Region: PRK09290
552536006745	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
552536006746	active site
552536006747	metal binding site [ion binding]; metal-binding site
552536006748	dimer interface [polypeptide binding]; other site
552536006749	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
552536006750	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
552536006751	NAD binding site [chemical binding]; other site
552536006752	sugar binding site [chemical binding]; other site
552536006753	divalent metal binding site [ion binding]; other site
552536006754	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536006755	dimer interface [polypeptide binding]; other site
552536006756	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536006757	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536006758	DNA binding site [nucleotide binding]
552536006759	domain linker motif; other site
552536006760	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
552536006761	putative dimerization interface [polypeptide binding]; other site
552536006762	putative ligand binding site [chemical binding]; other site
552536006763	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
552536006764	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
552536006765	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536006766	S-adenosylmethionine binding site [chemical binding]; other site
552536006767	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
552536006768	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
552536006769	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
552536006770	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
552536006771	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552536006772	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
552536006773	DXD motif; other site
552536006774	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
552536006775	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
552536006776	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552536006777	DNA binding residues [nucleotide binding]
552536006778	dimer interface [polypeptide binding]; other site
552536006779	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
552536006780	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
552536006781	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
552536006782	Sulfate transporter family; Region: Sulfate_transp; pfam00916
552536006783	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
552536006784	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
552536006785	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
552536006786	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536006787	putative active site [active]
552536006788	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
552536006789	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
552536006790	NAD binding site [chemical binding]; other site
552536006791	sugar binding site [chemical binding]; other site
552536006792	divalent metal binding site [ion binding]; other site
552536006793	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536006794	dimer interface [polypeptide binding]; other site
552536006795	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
552536006796	non-specific DNA interactions [nucleotide binding]; other site
552536006797	DNA binding site [nucleotide binding]
552536006798	sequence specific DNA binding site [nucleotide binding]; other site
552536006799	putative cAMP binding site [chemical binding]; other site
552536006800	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536006801	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552536006802	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536006803	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536006804	putative substrate translocation pore; other site
552536006805	Predicted membrane protein [Function unknown]; Region: COG3759
552536006806	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
552536006807	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
552536006808	CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203
552536006809	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
552536006810	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552536006811	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
552536006812	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
552536006813	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
552536006814	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
552536006815	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
552536006816	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
552536006817	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006818	catalytic core [active]
552536006819	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536006820	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
552536006821	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
552536006822	putative active site [active]
552536006823	putative metal binding site [ion binding]; other site
552536006824	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552536006825	Ligand Binding Site [chemical binding]; other site
552536006826	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006827	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006828	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536006829	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536006830	MarR family; Region: MarR_2; pfam12802
552536006831	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
552536006832	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
552536006833	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
552536006834	catalytic triad [active]
552536006835	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
552536006836	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
552536006837	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
552536006838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536006839	active site
552536006840	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
552536006841	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
552536006842	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
552536006843	active site
552536006844	P-loop; other site
552536006845	phosphorylation site [posttranslational modification]
552536006846	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552536006847	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
552536006848	putative NAD(P) binding site [chemical binding]; other site
552536006849	catalytic Zn binding site [ion binding]; other site
552536006850	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552536006851	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552536006852	substrate binding site [chemical binding]; other site
552536006853	hexamer interface [polypeptide binding]; other site
552536006854	metal binding site [ion binding]; metal-binding site
552536006855	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536006856	active site
552536006857	phosphorylation site [posttranslational modification]
552536006858	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
552536006859	putative active site [active]
552536006860	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536006861	PRD domain; Region: PRD; pfam00874
552536006862	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536006863	active site
552536006864	P-loop; other site
552536006865	phosphorylation site [posttranslational modification]
552536006866	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536006867	active site
552536006868	phosphorylation site [posttranslational modification]
552536006869	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
552536006870	catalytic residue [active]
552536006871	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552536006872	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552536006873	substrate binding site [chemical binding]; other site
552536006874	hexamer interface [polypeptide binding]; other site
552536006875	metal binding site [ion binding]; metal-binding site
552536006876	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
552536006877	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
552536006878	EamA-like transporter family; Region: EamA; pfam00892
552536006879	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
552536006880	EamA-like transporter family; Region: EamA; pfam00892
552536006881	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
552536006882	active site
552536006883	catalytic triad [active]
552536006884	oxyanion hole [active]
552536006885	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
552536006886	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
552536006887	active site
552536006888	catalytic residue [active]
552536006889	dimer interface [polypeptide binding]; other site
552536006890	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
552536006891	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
552536006892	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
552536006893	shikimate binding site; other site
552536006894	NAD(P) binding site [chemical binding]; other site
552536006895	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
552536006896	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
552536006897	active site
552536006898	FMN binding site [chemical binding]; other site
552536006899	substrate binding site [chemical binding]; other site
552536006900	putative catalytic residue [active]
552536006901	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
552536006902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536006903	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536006904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536006905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536006906	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
552536006907	putative dimerization interface [polypeptide binding]; other site
552536006908	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
552536006909	nudix motif; other site
552536006910	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
552536006911	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
552536006912	putative FMN binding site [chemical binding]; other site
552536006913	LXG domain of WXG superfamily; Region: LXG; pfam04740
552536006914	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
552536006915	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
552536006916	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
552536006917	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552536006918	FeS/SAM binding site; other site
552536006919	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
552536006920	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
552536006921	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536006922	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536006923	Zn2+ binding site [ion binding]; other site
552536006924	Mg2+ binding site [ion binding]; other site
552536006925	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
552536006926	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006927	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006928	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
552536006929	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006930	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006931	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006932	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
552536006933	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006934	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006935	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
552536006936	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536006937	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536006938	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
552536006939	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536006940	nucleotide binding site [chemical binding]; other site
552536006941	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
552536006942	Uncharacterized conserved protein [Function unknown]; Region: COG3535
552536006943	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
552536006944	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
552536006945	Na binding site [ion binding]; other site
552536006946	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
552536006947	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
552536006948	MoxR-like ATPases [General function prediction only]; Region: COG0714
552536006949	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536006950	Walker A motif; other site
552536006951	ATP binding site [chemical binding]; other site
552536006952	Walker B motif; other site
552536006953	arginine finger; other site
552536006954	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
552536006955	Protein of unknown function DUF58; Region: DUF58; pfam01882
552536006956	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
552536006957	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
552536006958	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
552536006959	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
552536006960	Predicted membrane protein [Function unknown]; Region: COG3619
552536006961	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
552536006962	Transcriptional regulator [Transcription]; Region: LytR; COG1316
552536006963	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
552536006964	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
552536006965	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
552536006966	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552536006967	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
552536006968	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
552536006969	nickel responsive regulator; Provisional; Region: PRK02967
552536006970	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552536006971	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
552536006972	NAD(P) binding site [chemical binding]; other site
552536006973	active site
552536006974	Predicted transcriptional regulator [Transcription]; Region: COG1959
552536006975	Transcriptional regulator; Region: Rrf2; pfam02082
552536006976	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536006977	Leucine rich repeat; Region: LRR_8; pfam13855
552536006978	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536006979	Leucine rich repeat; Region: LRR_8; pfam13855
552536006980	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536006981	LRR adjacent; Region: LRR_adjacent; pfam08191
552536006982	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536006983	SH3-like domain; Region: SH3_8; pfam13457
552536006984	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536006985	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536006986	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536006987	Substrate binding site [chemical binding]; other site
552536006988	LRR adjacent; Region: LRR_adjacent; pfam08191
552536006989	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536006990	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536006991	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536006992	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
552536006993	HEAT repeats; Region: HEAT_2; pfam13646
552536006994	HEAT repeats; Region: HEAT_2; pfam13646
552536006995	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
552536006996	RHS Repeat; Region: RHS_repeat; pfam05593
552536006997	RHS Repeat; Region: RHS_repeat; cl11982
552536006998	RHS Repeat; Region: RHS_repeat; pfam05593
552536006999	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
552536007000	RHS Repeat; Region: RHS_repeat; pfam05593
552536007001	RHS Repeat; Region: RHS_repeat; pfam05593
552536007002	RHS Repeat; Region: RHS_repeat; pfam05593
552536007003	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
552536007004	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
552536007005	classical (c) SDRs; Region: SDR_c; cd05233
552536007006	NAD(P) binding site [chemical binding]; other site
552536007007	active site
552536007008	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
552536007009	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
552536007010	active site
552536007011	substrate binding site [chemical binding]; other site
552536007012	trimer interface [polypeptide binding]; other site
552536007013	CoA binding site [chemical binding]; other site
552536007014	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552536007015	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552536007016	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552536007017	dimerization interface [polypeptide binding]; other site
552536007018	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
552536007019	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
552536007020	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
552536007021	active site
552536007022	metal binding site [ion binding]; metal-binding site
552536007023	catalytic site [active]
552536007024	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
552536007025	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536007026	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536007027	active site
552536007028	P-loop; other site
552536007029	phosphorylation site [posttranslational modification]
552536007030	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007031	active site
552536007032	phosphorylation site [posttranslational modification]
552536007033	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536007034	HTH domain; Region: HTH_11; pfam08279
552536007035	PRD domain; Region: PRD; pfam00874
552536007036	PRD domain; Region: PRD; pfam00874
552536007037	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536007038	active site
552536007039	P-loop; other site
552536007040	phosphorylation site [posttranslational modification]
552536007041	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007042	active site
552536007043	phosphorylation site [posttranslational modification]
552536007044	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
552536007045	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
552536007046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552536007047	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
552536007048	DNA binding residues [nucleotide binding]
552536007049	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
552536007050	Predicted transcriptional regulators [Transcription]; Region: COG1695
552536007051	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
552536007052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007053	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
552536007054	active site
552536007055	motif I; other site
552536007056	motif II; other site
552536007057	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007058	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536007059	non-specific DNA binding site [nucleotide binding]; other site
552536007060	salt bridge; other site
552536007061	sequence-specific DNA binding site [nucleotide binding]; other site
552536007062	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
552536007063	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
552536007064	NodB motif; other site
552536007065	active site
552536007066	catalytic site [active]
552536007067	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
552536007068	phosphoenolpyruvate synthase; Validated; Region: PRK06241
552536007069	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
552536007070	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
552536007071	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
552536007072	trimer interface [polypeptide binding]; other site
552536007073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
552536007074	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
552536007075	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536007076	putative metal binding site [ion binding]; other site
552536007077	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
552536007078	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536007079	HTH domain; Region: HTH_11; pfam08279
552536007080	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536007081	PRD domain; Region: PRD; pfam00874
552536007082	PRD domain; Region: PRD; pfam00874
552536007083	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536007084	active site
552536007085	P-loop; other site
552536007086	phosphorylation site [posttranslational modification]
552536007087	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007088	active site
552536007089	phosphorylation site [posttranslational modification]
552536007090	alpha-mannosidase; Provisional; Region: PRK09819
552536007091	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
552536007092	active site
552536007093	metal binding site [ion binding]; metal-binding site
552536007094	catalytic site [active]
552536007095	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
552536007096	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536007097	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536007098	active site
552536007099	P-loop; other site
552536007100	phosphorylation site [posttranslational modification]
552536007101	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007102	active site
552536007103	phosphorylation site [posttranslational modification]
552536007104	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
552536007105	putative hydrophobic ligand binding site [chemical binding]; other site
552536007106	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
552536007107	pyrroline-5-carboxylate reductase; Region: PLN02688
552536007108	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552536007109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536007110	Coenzyme A binding pocket [chemical binding]; other site
552536007111	Bacterial SH3 domain; Region: SH3_3; cl17532
552536007112	NlpC/P60 family; Region: NLPC_P60; pfam00877
552536007113	hypothetical protein; Provisional; Region: PRK13665
552536007114	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
552536007115	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
552536007116	ligand binding site [chemical binding]; other site
552536007117	active site
552536007118	UGI interface [polypeptide binding]; other site
552536007119	catalytic site [active]
552536007120	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
552536007121	Uncharacterized conserved protein [Function unknown]; Region: COG5646
552536007122	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
552536007123	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
552536007124	PYR/PP interface [polypeptide binding]; other site
552536007125	dimer interface [polypeptide binding]; other site
552536007126	TPP binding site [chemical binding]; other site
552536007127	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552536007128	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
552536007129	TPP-binding site; other site
552536007130	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
552536007131	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
552536007132	substrate binding site [chemical binding]; other site
552536007133	ATP binding site [chemical binding]; other site
552536007134	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
552536007135	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
552536007136	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
552536007137	tetrameric interface [polypeptide binding]; other site
552536007138	NAD binding site [chemical binding]; other site
552536007139	catalytic residues [active]
552536007140	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536007141	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
552536007142	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536007143	LXG domain of WXG superfamily; Region: LXG; pfam04740
552536007144	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
552536007145	Predicted transcriptional regulator [Transcription]; Region: COG2378
552536007146	HTH domain; Region: HTH_11; pfam08279
552536007147	WYL domain; Region: WYL; pfam13280
552536007148	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536007149	active site
552536007150	P-loop; other site
552536007151	phosphorylation site [posttranslational modification]
552536007152	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536007153	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
552536007154	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536007155	beta-galactosidase; Region: BGL; TIGR03356
552536007156	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536007157	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536007158	DNA-binding site [nucleotide binding]; DNA binding site
552536007159	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
552536007160	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
552536007161	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
552536007162	PhnA protein; Region: PhnA; pfam03831
552536007163	hypothetical protein; Provisional; Region: PRK12378
552536007164	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
552536007165	nudix motif; other site
552536007166	Predicted transcriptional regulator [Transcription]; Region: COG2378
552536007167	HTH domain; Region: HTH_11; pfam08279
552536007168	WYL domain; Region: WYL; pfam13280
552536007169	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
552536007170	conserved cys residue [active]
552536007171	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536007172	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
552536007173	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536007174	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
552536007175	intersubunit interface [polypeptide binding]; other site
552536007176	active site
552536007177	zinc binding site [ion binding]; other site
552536007178	Na+ binding site [ion binding]; other site
552536007179	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
552536007180	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536007181	active site
552536007182	P-loop; other site
552536007183	phosphorylation site [posttranslational modification]
552536007184	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536007185	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007186	active site
552536007187	phosphorylation site [posttranslational modification]
552536007188	putative oxidoreductase; Provisional; Region: PRK10206
552536007189	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536007190	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
552536007191	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
552536007192	L-aspartate oxidase; Provisional; Region: PRK06175
552536007193	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
552536007194	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
552536007195	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
552536007196	acyl-activating enzyme (AAE) consensus motif; other site
552536007197	acyl-activating enzyme (AAE) consensus motif; other site
552536007198	AMP binding site [chemical binding]; other site
552536007199	active site
552536007200	CoA binding site [chemical binding]; other site
552536007201	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
552536007202	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536007203	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536007204	Leucine-rich repeats; other site
552536007205	LRR adjacent; Region: LRR_adjacent; pfam08191
552536007206	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536007207	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536007208	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536007209	Coenzyme A binding pocket [chemical binding]; other site
552536007210	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552536007211	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536007212	putative DNA binding site [nucleotide binding]; other site
552536007213	putative Zn2+ binding site [ion binding]; other site
552536007214	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552536007215	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
552536007216	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
552536007217	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
552536007218	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
552536007219	DAK2 domain; Region: Dak2; cl03685
552536007220	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
552536007221	substrate binding site [chemical binding]; other site
552536007222	dimer interface [polypeptide binding]; other site
552536007223	catalytic triad [active]
552536007224	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
552536007225	short chain dehydrogenase; Provisional; Region: PRK06841
552536007226	classical (c) SDRs; Region: SDR_c; cd05233
552536007227	NAD(P) binding site [chemical binding]; other site
552536007228	active site
552536007229	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
552536007230	active site
552536007231	intersubunit interactions; other site
552536007232	catalytic residue [active]
552536007233	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
552536007234	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
552536007235	TPP-binding site [chemical binding]; other site
552536007236	dimer interface [polypeptide binding]; other site
552536007237	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552536007238	PYR/PP interface [polypeptide binding]; other site
552536007239	dimer interface [polypeptide binding]; other site
552536007240	TPP binding site [chemical binding]; other site
552536007241	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552536007242	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
552536007243	LXG domain of WXG superfamily; Region: LXG; pfam04740
552536007244	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
552536007245	Leucine rich repeat; Region: LRR_8; pfam13855
552536007246	LRR adjacent; Region: LRR_adjacent; pfam08191
552536007247	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
552536007248	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536007249	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536007250	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
552536007251	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
552536007252	Leucine rich repeat; Region: LRR_8; pfam13855
552536007253	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007254	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007255	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007256	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007257	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007258	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007259	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007260	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007261	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007262	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007263	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007264	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007265	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007266	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007267	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536007268	non-specific DNA binding site [nucleotide binding]; other site
552536007269	salt bridge; other site
552536007270	sequence-specific DNA binding site [nucleotide binding]; other site
552536007271	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
552536007272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536007273	non-specific DNA binding site [nucleotide binding]; other site
552536007274	salt bridge; other site
552536007275	sequence-specific DNA binding site [nucleotide binding]; other site
552536007276	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
552536007277	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
552536007278	putative catalytic site [active]
552536007279	putative metal binding site [ion binding]; other site
552536007280	putative phosphate binding site [ion binding]; other site
552536007281	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
552536007282	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
552536007283	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536007284	beta-galactosidase; Region: BGL; TIGR03356
552536007285	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
552536007286	thiamine phosphate binding site [chemical binding]; other site
552536007287	active site
552536007288	pyrophosphate binding site [ion binding]; other site
552536007289	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
552536007290	dimer interface [polypeptide binding]; other site
552536007291	substrate binding site [chemical binding]; other site
552536007292	ATP binding site [chemical binding]; other site
552536007293	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
552536007294	substrate binding site [chemical binding]; other site
552536007295	multimerization interface [polypeptide binding]; other site
552536007296	ATP binding site [chemical binding]; other site
552536007297	Putative transcription activator [Transcription]; Region: TenA; COG0819
552536007298	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
552536007299	putative active site [active]
552536007300	YdjC motif; other site
552536007301	Mg binding site [ion binding]; other site
552536007302	putative homodimer interface [polypeptide binding]; other site
552536007303	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
552536007304	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
552536007305	cofactor binding site; other site
552536007306	DNA binding site [nucleotide binding]
552536007307	substrate interaction site [chemical binding]; other site
552536007308	NgoPII restriction endonuclease; Region: RE_NgoPII; pfam09521
552536007309	Uncharacterized conserved protein [Function unknown]; Region: COG1479
552536007310	Protein of unknown function DUF262; Region: DUF262; pfam03235
552536007311	Protein of unknown function DUF262; Region: DUF262; pfam03235
552536007312	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
552536007313	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
552536007314	nucleophilic elbow; other site
552536007315	catalytic triad; other site
552536007316	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
552536007317	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
552536007318	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
552536007319	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536007320	catalytic residue [active]
552536007321	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536007322	methionine cluster; other site
552536007323	active site
552536007324	phosphorylation site [posttranslational modification]
552536007325	metal binding site [ion binding]; metal-binding site
552536007326	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536007327	beta-galactosidase; Region: BGL; TIGR03356
552536007328	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536007329	active site
552536007330	P-loop; other site
552536007331	phosphorylation site [posttranslational modification]
552536007332	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536007333	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536007334	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536007335	HTH domain; Region: HTH_11; pfam08279
552536007336	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536007337	PRD domain; Region: PRD; pfam00874
552536007338	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536007339	active site
552536007340	P-loop; other site
552536007341	phosphorylation site [posttranslational modification]
552536007342	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536007343	active site
552536007344	phosphorylation site [posttranslational modification]
552536007345	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
552536007346	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
552536007347	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
552536007348	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
552536007349	protein binding site [polypeptide binding]; other site
552536007350	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
552536007351	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
552536007352	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
552536007353	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
552536007354	YycH protein; Region: YycH; pfam07435
552536007355	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
552536007356	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552536007357	dimerization interface [polypeptide binding]; other site
552536007358	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
552536007359	putative active site [active]
552536007360	heme pocket [chemical binding]; other site
552536007361	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536007362	dimer interface [polypeptide binding]; other site
552536007363	phosphorylation site [posttranslational modification]
552536007364	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536007365	ATP binding site [chemical binding]; other site
552536007366	Mg2+ binding site [ion binding]; other site
552536007367	G-X-G motif; other site
552536007368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536007369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536007370	active site
552536007371	phosphorylation site [posttranslational modification]
552536007372	intermolecular recognition site; other site
552536007373	dimerization interface [polypeptide binding]; other site
552536007374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536007375	DNA binding site [nucleotide binding]
552536007376	transaminase; Reviewed; Region: PRK08068
552536007377	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552536007378	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536007379	homodimer interface [polypeptide binding]; other site
552536007380	catalytic residue [active]
552536007381	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
552536007382	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
552536007383	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
552536007384	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
552536007385	Walker A/P-loop; other site
552536007386	ATP binding site [chemical binding]; other site
552536007387	Q-loop/lid; other site
552536007388	ABC transporter signature motif; other site
552536007389	Walker B; other site
552536007390	D-loop; other site
552536007391	H-loop/switch region; other site
552536007392	NIL domain; Region: NIL; pfam09383
552536007393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007394	dimer interface [polypeptide binding]; other site
552536007395	conserved gate region; other site
552536007396	ABC-ATPase subunit interface; other site
552536007397	Predicted amidohydrolase [General function prediction only]; Region: COG0388
552536007398	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
552536007399	putative active site [active]
552536007400	catalytic triad [active]
552536007401	putative dimer interface [polypeptide binding]; other site
552536007402	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536007403	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536007404	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
552536007405	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
552536007406	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
552536007407	ATP cone domain; Region: ATP-cone; pfam03477
552536007408	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
552536007409	Class III ribonucleotide reductase; Region: RNR_III; cd01675
552536007410	effector binding site; other site
552536007411	active site
552536007412	Zn binding site [ion binding]; other site
552536007413	glycine loop; other site
552536007414	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
552536007415	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
552536007416	Walker A/P-loop; other site
552536007417	ATP binding site [chemical binding]; other site
552536007418	Q-loop/lid; other site
552536007419	ABC transporter signature motif; other site
552536007420	Walker B; other site
552536007421	D-loop; other site
552536007422	H-loop/switch region; other site
552536007423	TOBE domain; Region: TOBE; pfam03459
552536007424	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536007425	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536007426	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
552536007427	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007428	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
552536007429	active site
552536007430	motif I; other site
552536007431	motif II; other site
552536007432	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007433	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
552536007434	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
552536007435	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536007436	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536007437	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536007438	Coenzyme A binding pocket [chemical binding]; other site
552536007439	sugar phosphate phosphatase; Provisional; Region: PRK10513
552536007440	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007441	active site
552536007442	motif I; other site
552536007443	motif II; other site
552536007444	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536007445	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536007446	beta-galactosidase; Region: BGL; TIGR03356
552536007447	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
552536007448	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
552536007449	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552536007450	Leucine-rich repeats; other site
552536007451	Substrate binding site [chemical binding]; other site
552536007452	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
552536007453	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
552536007454	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
552536007455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007456	dimer interface [polypeptide binding]; other site
552536007457	conserved gate region; other site
552536007458	ABC-ATPase subunit interface; other site
552536007459	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552536007460	catalytic core [active]
552536007461	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
552536007462	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
552536007463	Zn binding site [ion binding]; other site
552536007464	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
552536007465	Zn binding site [ion binding]; other site
552536007466	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536007467	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536007468	putative Zn2+ binding site [ion binding]; other site
552536007469	putative DNA binding site [nucleotide binding]; other site
552536007470	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
552536007471	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
552536007472	metal binding site [ion binding]; metal-binding site
552536007473	dimer interface [polypeptide binding]; other site
552536007474	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536007475	beta-galactosidase; Region: BGL; TIGR03356
552536007476	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
552536007477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007478	active site
552536007479	motif I; other site
552536007480	motif II; other site
552536007481	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
552536007482	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
552536007483	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
552536007484	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
552536007485	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
552536007486	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
552536007487	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
552536007488	G-loop; other site
552536007489	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
552536007490	DNA binding site [nucleotide binding]
552536007491	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
552536007492	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
552536007493	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
552536007494	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
552536007495	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
552536007496	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
552536007497	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
552536007498	RPB10 interaction site [polypeptide binding]; other site
552536007499	RPB1 interaction site [polypeptide binding]; other site
552536007500	RPB11 interaction site [polypeptide binding]; other site
552536007501	RPB3 interaction site [polypeptide binding]; other site
552536007502	RPB12 interaction site [polypeptide binding]; other site
552536007503	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
552536007504	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
552536007505	active site
552536007506	homodimer interface [polypeptide binding]; other site
552536007507	catalytic site [active]
552536007508	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
552536007509	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
552536007510	Ca binding site [ion binding]; other site
552536007511	active site
552536007512	catalytic site [active]
552536007513	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536007514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007515	dimer interface [polypeptide binding]; other site
552536007516	conserved gate region; other site
552536007517	putative PBP binding loops; other site
552536007518	ABC-ATPase subunit interface; other site
552536007519	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
552536007520	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007521	dimer interface [polypeptide binding]; other site
552536007522	conserved gate region; other site
552536007523	putative PBP binding loops; other site
552536007524	ABC-ATPase subunit interface; other site
552536007525	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
552536007526	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536007527	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536007528	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536007529	DNA binding site [nucleotide binding]
552536007530	domain linker motif; other site
552536007531	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
552536007532	putative dimerization interface [polypeptide binding]; other site
552536007533	putative ligand binding site [chemical binding]; other site
552536007534	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
552536007535	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
552536007536	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
552536007537	Methyltransferase domain; Region: Methyltransf_31; pfam13847
552536007538	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536007539	S-adenosylmethionine binding site [chemical binding]; other site
552536007540	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
552536007541	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
552536007542	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
552536007543	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
552536007544	Penicillinase repressor; Region: Pencillinase_R; pfam03965
552536007545	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
552536007546	core dimer interface [polypeptide binding]; other site
552536007547	peripheral dimer interface [polypeptide binding]; other site
552536007548	L10 interface [polypeptide binding]; other site
552536007549	L11 interface [polypeptide binding]; other site
552536007550	putative EF-Tu interaction site [polypeptide binding]; other site
552536007551	putative EF-G interaction site [polypeptide binding]; other site
552536007552	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
552536007553	23S rRNA interface [nucleotide binding]; other site
552536007554	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
552536007555	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
552536007556	mRNA/rRNA interface [nucleotide binding]; other site
552536007557	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
552536007558	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
552536007559	23S rRNA interface [nucleotide binding]; other site
552536007560	L7/L12 interface [polypeptide binding]; other site
552536007561	putative thiostrepton binding site; other site
552536007562	L25 interface [polypeptide binding]; other site
552536007563	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
552536007564	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
552536007565	putative homodimer interface [polypeptide binding]; other site
552536007566	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
552536007567	heterodimer interface [polypeptide binding]; other site
552536007568	homodimer interface [polypeptide binding]; other site
552536007569	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
552536007570	RNA polymerase factor sigma-70; Validated; Region: PRK08295
552536007571	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552536007572	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
552536007573	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
552536007574	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
552536007575	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
552536007576	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
552536007577	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
552536007578	active site
552536007579	metal binding site [ion binding]; metal-binding site
552536007580	dimerization interface [polypeptide binding]; other site
552536007581	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
552536007582	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
552536007583	active site
552536007584	HIGH motif; other site
552536007585	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
552536007586	KMSKS motif; other site
552536007587	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
552536007588	tRNA binding surface [nucleotide binding]; other site
552536007589	anticodon binding site; other site
552536007590	serine O-acetyltransferase; Region: cysE; TIGR01172
552536007591	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
552536007592	trimer interface [polypeptide binding]; other site
552536007593	active site
552536007594	substrate binding site [chemical binding]; other site
552536007595	CoA binding site [chemical binding]; other site
552536007596	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
552536007597	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
552536007598	HIGH motif; other site
552536007599	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
552536007600	active site
552536007601	KMSKS motif; other site
552536007602	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
552536007603	homotrimer interaction site [polypeptide binding]; other site
552536007604	zinc binding site [ion binding]; other site
552536007605	CDP-binding sites; other site
552536007606	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
552536007607	substrate binding site; other site
552536007608	dimer interface; other site
552536007609	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
552536007610	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
552536007611	putative active site [active]
552536007612	DNA repair protein RadA; Provisional; Region: PRK11823
552536007613	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
552536007614	Walker A motif/ATP binding site; other site
552536007615	ATP binding site [chemical binding]; other site
552536007616	Walker B motif; other site
552536007617	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
552536007618	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
552536007619	Clp amino terminal domain; Region: Clp_N; pfam02861
552536007620	Clp amino terminal domain; Region: Clp_N; pfam02861
552536007621	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536007622	Walker A motif; other site
552536007623	ATP binding site [chemical binding]; other site
552536007624	Walker B motif; other site
552536007625	arginine finger; other site
552536007626	UvrB/uvrC motif; Region: UVR; pfam02151
552536007627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536007628	Walker A motif; other site
552536007629	ATP binding site [chemical binding]; other site
552536007630	Walker B motif; other site
552536007631	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
552536007632	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
552536007633	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
552536007634	ADP binding site [chemical binding]; other site
552536007635	phosphagen binding site; other site
552536007636	substrate specificity loop; other site
552536007637	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
552536007638	UvrB/uvrC motif; Region: UVR; pfam02151
552536007639	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
552536007640	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
552536007641	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
552536007642	dimer interface [polypeptide binding]; other site
552536007643	putative anticodon binding site; other site
552536007644	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
552536007645	motif 1; other site
552536007646	active site
552536007647	motif 2; other site
552536007648	motif 3; other site
552536007649	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
552536007650	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
552536007651	FMN binding site [chemical binding]; other site
552536007652	active site
552536007653	catalytic residues [active]
552536007654	substrate binding site [chemical binding]; other site
552536007655	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
552536007656	catalytic center binding site [active]
552536007657	ATP binding site [chemical binding]; other site
552536007658	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
552536007659	homooctamer interface [polypeptide binding]; other site
552536007660	active site
552536007661	dihydropteroate synthase; Region: DHPS; TIGR01496
552536007662	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
552536007663	substrate binding pocket [chemical binding]; other site
552536007664	dimer interface [polypeptide binding]; other site
552536007665	inhibitor binding site; inhibition site
552536007666	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
552536007667	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
552536007668	dimer interface [polypeptide binding]; other site
552536007669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536007670	catalytic residue [active]
552536007671	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
552536007672	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
552536007673	dimerization interface [polypeptide binding]; other site
552536007674	domain crossover interface; other site
552536007675	redox-dependent activation switch; other site
552536007676	pantothenate kinase; Reviewed; Region: PRK13318
552536007677	FtsH Extracellular; Region: FtsH_ext; pfam06480
552536007678	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
552536007679	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536007680	Walker A motif; other site
552536007681	ATP binding site [chemical binding]; other site
552536007682	Walker B motif; other site
552536007683	arginine finger; other site
552536007684	Peptidase family M41; Region: Peptidase_M41; pfam01434
552536007685	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
552536007686	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
552536007687	Ligand Binding Site [chemical binding]; other site
552536007688	TilS substrate C-terminal domain; Region: TilS_C; smart00977
552536007689	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
552536007690	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536007691	active site
552536007692	hypothetical protein; Provisional; Region: PRK08582
552536007693	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
552536007694	RNA binding site [nucleotide binding]; other site
552536007695	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
552536007696	Septum formation initiator; Region: DivIC; pfam04977
552536007697	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552536007698	RNA binding surface [nucleotide binding]; other site
552536007699	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
552536007700	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
552536007701	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
552536007702	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
552536007703	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536007704	ATP binding site [chemical binding]; other site
552536007705	putative Mg++ binding site [ion binding]; other site
552536007706	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536007707	nucleotide binding region [chemical binding]; other site
552536007708	ATP-binding site [chemical binding]; other site
552536007709	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
552536007710	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
552536007711	putative active site [active]
552536007712	catalytic residue [active]
552536007713	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552536007714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536007715	Coenzyme A binding pocket [chemical binding]; other site
552536007716	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
552536007717	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
552536007718	5S rRNA interface [nucleotide binding]; other site
552536007719	CTC domain interface [polypeptide binding]; other site
552536007720	L16 interface [polypeptide binding]; other site
552536007721	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
552536007722	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
552536007723	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536007724	NAD binding site [chemical binding]; other site
552536007725	dimer interface [polypeptide binding]; other site
552536007726	substrate binding site [chemical binding]; other site
552536007727	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
552536007728	A new structural DNA glycosylase; Region: AlkD_like; cl11434
552536007729	active site
552536007730	hypothetical protein; Provisional; Region: PRK01119
552536007731	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
552536007732	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
552536007733	Zn binding site [ion binding]; other site
552536007734	ActA Protein; Region: ActA; pfam05058
552536007735	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
552536007736	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
552536007737	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
552536007738	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
552536007739	active site
552536007740	Zn binding site [ion binding]; other site
552536007741	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
552536007742	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
552536007743	active site
552536007744	catalytic site [active]
552536007745	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536007746	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536007747	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
552536007748	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
552536007749	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
552536007750	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536007751	active site
552536007752	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
552536007753	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
552536007754	Substrate binding site; other site
552536007755	Mg++ binding site; other site
552536007756	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
552536007757	active site
552536007758	substrate binding site [chemical binding]; other site
552536007759	CoA binding site [chemical binding]; other site
552536007760	regulatory protein SpoVG; Reviewed; Region: PRK13259
552536007761	regulatory protein SpoVG; Reviewed; Region: PRK13259
552536007762	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552536007763	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552536007764	FtsX-like permease family; Region: FtsX; pfam02687
552536007765	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552536007766	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536007767	Walker A/P-loop; other site
552536007768	ATP binding site [chemical binding]; other site
552536007769	Q-loop/lid; other site
552536007770	ABC transporter signature motif; other site
552536007771	Walker B; other site
552536007772	D-loop; other site
552536007773	H-loop/switch region; other site
552536007774	HlyD family secretion protein; Region: HlyD_3; pfam13437
552536007775	pur operon repressor; Provisional; Region: PRK09213
552536007776	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
552536007777	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552536007778	active site
552536007779	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
552536007780	putative active site [active]
552536007781	YdjC motif; other site
552536007782	Mg binding site [ion binding]; other site
552536007783	putative homodimer interface [polypeptide binding]; other site
552536007784	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
552536007785	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
552536007786	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
552536007787	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
552536007788	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536007789	S-adenosylmethionine binding site [chemical binding]; other site
552536007790	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
552536007791	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
552536007792	putative active site [active]
552536007793	putative metal binding site [ion binding]; other site
552536007794	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
552536007795	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
552536007796	Domain of unknown function (DUF348); Region: DUF348; pfam03990
552536007797	Domain of unknown function (DUF348); Region: DUF348; pfam03990
552536007798	G5 domain; Region: G5; pfam07501
552536007799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
552536007800	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
552536007801	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
552536007802	active site
552536007803	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
552536007804	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
552536007805	Ca binding site [ion binding]; other site
552536007806	active site
552536007807	catalytic site [active]
552536007808	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
552536007809	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
552536007810	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
552536007811	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
552536007812	trimer interface [polypeptide binding]; other site
552536007813	active site
552536007814	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
552536007815	catalytic site [active]
552536007816	alpha-glucosidase; Provisional; Region: PRK10426
552536007817	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
552536007818	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
552536007819	active site
552536007820	catalytic site [active]
552536007821	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
552536007822	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536007823	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536007824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007825	dimer interface [polypeptide binding]; other site
552536007826	conserved gate region; other site
552536007827	putative PBP binding loops; other site
552536007828	ABC-ATPase subunit interface; other site
552536007829	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
552536007830	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007831	dimer interface [polypeptide binding]; other site
552536007832	conserved gate region; other site
552536007833	putative PBP binding loops; other site
552536007834	ABC-ATPase subunit interface; other site
552536007835	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
552536007836	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536007837	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536007838	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552536007839	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
552536007840	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
552536007841	active site
552536007842	HIGH motif; other site
552536007843	KMSKS motif; other site
552536007844	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
552536007845	tRNA binding surface [nucleotide binding]; other site
552536007846	anticodon binding site; other site
552536007847	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
552536007848	dimer interface [polypeptide binding]; other site
552536007849	putative tRNA-binding site [nucleotide binding]; other site
552536007850	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
552536007851	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
552536007852	Uncharacterized conserved protein [Function unknown]; Region: COG5361
552536007853	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
552536007854	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
552536007855	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
552536007856	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
552536007857	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
552536007858	Predicted methyltransferases [General function prediction only]; Region: COG0313
552536007859	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
552536007860	putative SAM binding site [chemical binding]; other site
552536007861	putative homodimer interface [polypeptide binding]; other site
552536007862	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
552536007863	GIY-YIG motif/motif A; other site
552536007864	putative active site [active]
552536007865	putative metal binding site [ion binding]; other site
552536007866	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
552536007867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536007868	S-adenosylmethionine binding site [chemical binding]; other site
552536007869	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
552536007870	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
552536007871	DNA polymerase III subunit delta'; Validated; Region: PRK08058
552536007872	DNA polymerase III subunit delta'; Validated; Region: PRK08485
552536007873	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
552536007874	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
552536007875	Collagen binding domain; Region: Collagen_bind; pfam05737
552536007876	Cna protein B-type domain; Region: Cna_B; pfam05738
552536007877	Cna protein B-type domain; Region: Cna_B; pfam05738
552536007878	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
552536007879	Collagen binding domain; Region: Collagen_bind; pfam05737
552536007880	Cna protein B-type domain; Region: Cna_B; pfam05738
552536007881	Cna protein B-type domain; Region: Cna_B; pfam05738
552536007882	Cna protein B-type domain; Region: Cna_B; pfam05738
552536007883	sugar phosphate phosphatase; Provisional; Region: PRK10513
552536007884	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007885	active site
552536007886	motif I; other site
552536007887	motif II; other site
552536007888	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536007889	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
552536007890	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
552536007891	DEAD_2; Region: DEAD_2; pfam06733
552536007892	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
552536007893	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536007894	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536007895	ligand binding site [chemical binding]; other site
552536007896	flexible hinge region; other site
552536007897	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
552536007898	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
552536007899	ABC-ATPase subunit  interface; other site
552536007900	dimer interface [polypeptide binding]; other site
552536007901	putative PBP binding regions; other site
552536007902	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
552536007903	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
552536007904	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
552536007905	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
552536007906	metal binding site [ion binding]; metal-binding site
552536007907	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
552536007908	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
552536007909	peptide binding site [polypeptide binding]; other site
552536007910	phosphoenolpyruvate synthase; Validated; Region: PRK06464
552536007911	ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346
552536007912	LXG domain of WXG superfamily; Region: LXG; pfam04740
552536007913	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
552536007914	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
552536007915	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
552536007916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007917	dimer interface [polypeptide binding]; other site
552536007918	conserved gate region; other site
552536007919	putative PBP binding loops; other site
552536007920	ABC-ATPase subunit interface; other site
552536007921	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
552536007922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536007923	dimer interface [polypeptide binding]; other site
552536007924	conserved gate region; other site
552536007925	putative PBP binding loops; other site
552536007926	ABC-ATPase subunit interface; other site
552536007927	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
552536007928	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
552536007929	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536007930	Coenzyme A binding pocket [chemical binding]; other site
552536007931	Uncharacterized conserved protein [Function unknown]; Region: COG3592
552536007932	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
552536007933	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
552536007934	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
552536007935	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
552536007936	active site
552536007937	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
552536007938	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
552536007939	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
552536007940	putative active site [active]
552536007941	putative metal binding site [ion binding]; other site
552536007942	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
552536007943	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
552536007944	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
552536007945	active site
552536007946	metal binding site [ion binding]; metal-binding site
552536007947	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
552536007948	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
552536007949	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536007950	non-specific DNA binding site [nucleotide binding]; other site
552536007951	salt bridge; other site
552536007952	sequence-specific DNA binding site [nucleotide binding]; other site
552536007953	Domain of unknown function (DUF955); Region: DUF955; pfam06114
552536007954	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536007955	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
552536007956	ligand binding site [chemical binding]; other site
552536007957	flexible hinge region; other site
552536007958	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
552536007959	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
552536007960	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
552536007961	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
552536007962	substrate binding pocket [chemical binding]; other site
552536007963	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552536007964	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536007965	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536007966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536007967	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
552536007968	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536007969	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536007970	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
552536007971	Walker A/P-loop; other site
552536007972	ATP binding site [chemical binding]; other site
552536007973	Q-loop/lid; other site
552536007974	ABC transporter signature motif; other site
552536007975	Walker B; other site
552536007976	D-loop; other site
552536007977	H-loop/switch region; other site
552536007978	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536007979	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536007980	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
552536007981	Walker A/P-loop; other site
552536007982	ATP binding site [chemical binding]; other site
552536007983	Q-loop/lid; other site
552536007984	ABC transporter signature motif; other site
552536007985	Walker B; other site
552536007986	D-loop; other site
552536007987	H-loop/switch region; other site
552536007988	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536007989	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536007990	nucleotide binding site [chemical binding]; other site
552536007991	butyrate kinase; Region: butyr_kinase; TIGR02707
552536007992	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
552536007993	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
552536007994	active site
552536007995	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
552536007996	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
552536007997	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
552536007998	aromatic chitin/cellulose binding site residues [chemical binding]; other site
552536007999	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
552536008000	dimer interface [polypeptide binding]; other site
552536008001	FMN binding site [chemical binding]; other site
552536008002	Uncharacterized conserved protein [Function unknown]; Region: COG1359
552536008003	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
552536008004	dimerization interface [polypeptide binding]; other site
552536008005	putative DNA binding site [nucleotide binding]; other site
552536008006	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
552536008007	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
552536008008	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
552536008009	Domain of unknown function (DUF956); Region: DUF956; pfam06115
552536008010	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
552536008011	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
552536008012	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
552536008013	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536008014	active pocket/dimerization site; other site
552536008015	active site
552536008016	phosphorylation site [posttranslational modification]
552536008017	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
552536008018	active site
552536008019	phosphorylation site [posttranslational modification]
552536008020	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536008021	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008022	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008023	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008024	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008025	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008026	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008027	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
552536008028	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
552536008029	gamma subunit interface [polypeptide binding]; other site
552536008030	epsilon subunit interface [polypeptide binding]; other site
552536008031	LBP interface [polypeptide binding]; other site
552536008032	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
552536008033	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
552536008034	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
552536008035	alpha subunit interaction interface [polypeptide binding]; other site
552536008036	Walker A motif; other site
552536008037	ATP binding site [chemical binding]; other site
552536008038	Walker B motif; other site
552536008039	inhibitor binding site; inhibition site
552536008040	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552536008041	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
552536008042	core domain interface [polypeptide binding]; other site
552536008043	delta subunit interface [polypeptide binding]; other site
552536008044	epsilon subunit interface [polypeptide binding]; other site
552536008045	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
552536008046	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552536008047	Walker A motif; other site
552536008048	ATP binding site [chemical binding]; other site
552536008049	Walker B motif; other site
552536008050	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552536008051	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
552536008052	ATP synthase subunit C; Region: ATP-synt_C; cl00466
552536008053	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536008054	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
552536008055	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536008056	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536008057	active site
552536008058	catalytic tetrad [active]
552536008059	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536008060	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536008061	DNA binding residues [nucleotide binding]
552536008062	putative dimer interface [polypeptide binding]; other site
552536008063	TM2 domain; Region: TM2; pfam05154
552536008064	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
552536008065	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
552536008066	amidase catalytic site [active]
552536008067	Zn binding residues [ion binding]; other site
552536008068	substrate binding site [chemical binding]; other site
552536008069	Bacteriophage holin; Region: Phage_holin_1; pfam04531
552536008070	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
552536008071	Phage capsid family; Region: Phage_capsid; pfam05065
552536008072	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
552536008073	oligomer interface [polypeptide binding]; other site
552536008074	active site residues [active]
552536008075	Phage portal protein; Region: Phage_portal; pfam04860
552536008076	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
552536008077	HTH domain; Region: HTH_11; cl17392
552536008078	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
552536008079	putative metal binding site [ion binding]; other site
552536008080	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
552536008081	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536008082	ATP binding site [chemical binding]; other site
552536008083	putative Mg++ binding site [ion binding]; other site
552536008084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536008085	nucleotide binding region [chemical binding]; other site
552536008086	ATP-binding site [chemical binding]; other site
552536008087	VRR-NUC domain; Region: VRR_NUC; pfam08774
552536008088	Virulence-associated protein E; Region: VirE; pfam05272
552536008089	YopX protein; Region: YopX; pfam09643
552536008090	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
552536008091	active site
552536008092	DNA binding site [nucleotide binding]
552536008093	catalytic site [active]
552536008094	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
552536008095	Protein of unknown function (DUF2800); Region: DUF2800; pfam10926
552536008096	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
552536008097	Helix-turn-helix domain; Region: HTH_17; pfam12728
552536008098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536008099	non-specific DNA binding site [nucleotide binding]; other site
552536008100	salt bridge; other site
552536008101	sequence-specific DNA binding site [nucleotide binding]; other site
552536008102	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536008103	non-specific DNA binding site [nucleotide binding]; other site
552536008104	salt bridge; other site
552536008105	sequence-specific DNA binding site [nucleotide binding]; other site
552536008106	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
552536008107	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
552536008108	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
552536008109	Int/Topo IB signature motif; other site
552536008110	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
552536008111	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
552536008112	putative ligand binding site [chemical binding]; other site
552536008113	putative NAD binding site [chemical binding]; other site
552536008114	catalytic site [active]
552536008115	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
552536008116	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
552536008117	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
552536008118	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
552536008119	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
552536008120	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
552536008121	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
552536008122	DNA binding site [nucleotide binding]
552536008123	active site
552536008124	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
552536008125	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
552536008126	tetramer interface [polypeptide binding]; other site
552536008127	active site
552536008128	Mg2+/Mn2+ binding site [ion binding]; other site
552536008129	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
552536008130	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
552536008131	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
552536008132	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
552536008133	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552536008134	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552536008135	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
552536008136	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
552536008137	Uncharacterized small protein [Function unknown]; Region: COG5417
552536008138	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
552536008139	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
552536008140	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
552536008141	Predicted membrane protein [Function unknown]; Region: COG1511
552536008142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
552536008143	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
552536008144	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
552536008145	GDP-binding site [chemical binding]; other site
552536008146	ACT binding site; other site
552536008147	IMP binding site; other site
552536008148	replicative DNA helicase; Provisional; Region: PRK05748
552536008149	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
552536008150	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
552536008151	Walker A motif; other site
552536008152	ATP binding site [chemical binding]; other site
552536008153	Walker B motif; other site
552536008154	DNA binding loops [nucleotide binding]
552536008155	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
552536008156	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
552536008157	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
552536008158	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
552536008159	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
552536008160	DHH family; Region: DHH; pfam01368
552536008161	DHHA1 domain; Region: DHHA1; pfam02272
552536008162	Response regulator receiver domain; Region: Response_reg; pfam00072
552536008163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536008164	active site
552536008165	phosphorylation site [posttranslational modification]
552536008166	intermolecular recognition site; other site
552536008167	dimerization interface [polypeptide binding]; other site
552536008168	LytTr DNA-binding domain; Region: LytTR; pfam04397
552536008169	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
552536008170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536008171	ATP binding site [chemical binding]; other site
552536008172	Mg2+ binding site [ion binding]; other site
552536008173	G-X-G motif; other site
552536008174	Staphylococcal AgrD protein; Region: AgrD; cl05477
552536008175	putative accessory gene regulator protein; Provisional; Region: PRK01100
552536008176	Predicted membrane protein [Function unknown]; Region: COG3212
552536008177	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
552536008178	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
552536008179	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
552536008180	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
552536008181	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
552536008182	dimer interface [polypeptide binding]; other site
552536008183	ssDNA binding site [nucleotide binding]; other site
552536008184	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536008185	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
552536008186	arginine deiminase; Provisional; Region: PRK01388
552536008187	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
552536008188	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
552536008189	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
552536008190	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
552536008191	dimer interface [polypeptide binding]; other site
552536008192	active site
552536008193	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
552536008194	dimer interface [polypeptide binding]; other site
552536008195	active site
552536008196	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536008197	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536008198	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
552536008199	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
552536008200	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536008201	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536008202	nucleotide binding site [chemical binding]; other site
552536008203	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536008204	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536008205	DNA binding site [nucleotide binding]
552536008206	domain linker motif; other site
552536008207	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
552536008208	dimerization interface [polypeptide binding]; other site
552536008209	putative ligand binding site [chemical binding]; other site
552536008210	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536008211	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008212	active site
552536008213	motif I; other site
552536008214	motif II; other site
552536008215	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008216	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
552536008217	putative dimer interface [polypeptide binding]; other site
552536008218	catalytic triad [active]
552536008219	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
552536008220	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
552536008221	active site turn [active]
552536008222	phosphorylation site [posttranslational modification]
552536008223	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
552536008224	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
552536008225	HPr interaction site; other site
552536008226	glycerol kinase (GK) interaction site [polypeptide binding]; other site
552536008227	active site
552536008228	phosphorylation site [posttranslational modification]
552536008229	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
552536008230	hypothetical protein; Provisional; Region: PRK02947
552536008231	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536008232	putative active site [active]
552536008233	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
552536008234	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
552536008235	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
552536008236	active site
552536008237	phosphorylation site [posttranslational modification]
552536008238	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
552536008239	active site
552536008240	active pocket/dimerization site; other site
552536008241	phosphorylation site [posttranslational modification]
552536008242	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
552536008243	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552536008244	DNA-binding site [nucleotide binding]; DNA binding site
552536008245	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
552536008246	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
552536008247	Bacterial SH3 domain; Region: SH3_3; pfam08239
552536008248	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
552536008249	putative active site [active]
552536008250	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
552536008251	beta-galactosidase; Region: BGL; TIGR03356
552536008252	cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901
552536008253	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
552536008254	Subunit I/III interface [polypeptide binding]; other site
552536008255	Subunit III/IV interface [polypeptide binding]; other site
552536008256	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
552536008257	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
552536008258	D-pathway; other site
552536008259	Putative ubiquinol binding site [chemical binding]; other site
552536008260	Low-spin heme (heme b) binding site [chemical binding]; other site
552536008261	Putative water exit pathway; other site
552536008262	Binuclear center (heme o3/CuB) [ion binding]; other site
552536008263	K-pathway; other site
552536008264	Putative proton exit pathway; other site
552536008265	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
552536008266	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
552536008267	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
552536008268	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
552536008269	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
552536008270	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
552536008271	diphosphomevalonate decarboxylase; Region: PLN02407
552536008272	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
552536008273	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
552536008274	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
552536008275	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
552536008276	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536008277	Coenzyme A binding pocket [chemical binding]; other site
552536008278	cardiolipin synthetase; Reviewed; Region: PRK12452
552536008279	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
552536008280	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
552536008281	putative active site [active]
552536008282	catalytic site [active]
552536008283	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
552536008284	putative active site [active]
552536008285	catalytic site [active]
552536008286	DNA gyrase subunit A; Validated; Region: PRK05560
552536008287	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
552536008288	CAP-like domain; other site
552536008289	active site
552536008290	primary dimer interface [polypeptide binding]; other site
552536008291	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536008292	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536008293	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536008294	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536008295	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552536008296	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
552536008297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536008298	Mg2+ binding site [ion binding]; other site
552536008299	G-X-G motif; other site
552536008300	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
552536008301	anchoring element; other site
552536008302	dimer interface [polypeptide binding]; other site
552536008303	ATP binding site [chemical binding]; other site
552536008304	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
552536008305	active site
552536008306	putative metal-binding site [ion binding]; other site
552536008307	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
552536008308	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
552536008309	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
552536008310	Walker A/P-loop; other site
552536008311	ATP binding site [chemical binding]; other site
552536008312	Q-loop/lid; other site
552536008313	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536008314	ABC transporter signature motif; other site
552536008315	Walker B; other site
552536008316	D-loop; other site
552536008317	H-loop/switch region; other site
552536008318	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
552536008319	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
552536008320	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
552536008321	DNA polymerase III subunit beta; Validated; Region: PRK05643
552536008322	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
552536008323	putative DNA binding surface [nucleotide binding]; other site
552536008324	dimer interface [polypeptide binding]; other site
552536008325	beta-clamp/clamp loader binding surface; other site
552536008326	beta-clamp/translesion DNA polymerase binding surface; other site
552536008327	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
552536008328	DnaA N-terminal domain; Region: DnaA_N; pfam11638
552536008329	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536008330	Walker A motif; other site
552536008331	ATP binding site [chemical binding]; other site
552536008332	Walker B motif; other site
552536008333	arginine finger; other site
552536008334	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
552536008335	DnaA box-binding interface [nucleotide binding]; other site
552536008336	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
552536008337	ribonuclease P; Reviewed; Region: rnpA; PRK00499
552536008338	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
552536008339	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
552536008340	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
552536008341	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
552536008342	G-X-X-G motif; other site
552536008343	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
552536008344	RxxxH motif; other site
552536008345	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
552536008346	Cupin domain; Region: Cupin_2; pfam07883
552536008347	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536008348	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008349	putative substrate translocation pore; other site
552536008350	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536008351	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
552536008352	N- and C-terminal domain interface [polypeptide binding]; other site
552536008353	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
552536008354	active site
552536008355	putative catalytic site [active]
552536008356	metal binding site [ion binding]; metal-binding site
552536008357	ATP binding site [chemical binding]; other site
552536008358	carbohydrate binding site [chemical binding]; other site
552536008359	L-rhamnose isomerase; Provisional; Region: PRK01076
552536008360	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
552536008361	intersubunit interface [polypeptide binding]; other site
552536008362	active site
552536008363	Zn2+ binding site [ion binding]; other site
552536008364	Domain of unknown function (DUF718); Region: DUF718; cl01281
552536008365	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008366	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536008367	putative substrate translocation pore; other site
552536008368	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008369	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
552536008370	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536008371	Coenzyme A binding pocket [chemical binding]; other site
552536008372	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
552536008373	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536008374	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536008375	DNA binding site [nucleotide binding]
552536008376	domain linker motif; other site
552536008377	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
552536008378	putative dimerization interface [polypeptide binding]; other site
552536008379	putative ligand binding site [chemical binding]; other site
552536008380	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
552536008381	sucrose phosphorylase; Provisional; Region: PRK13840
552536008382	active site
552536008383	homodimer interface [polypeptide binding]; other site
552536008384	catalytic site [active]
552536008385	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
552536008386	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552536008387	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536008388	dimer interface [polypeptide binding]; other site
552536008389	conserved gate region; other site
552536008390	putative PBP binding loops; other site
552536008391	ABC-ATPase subunit interface; other site
552536008392	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552536008393	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552536008394	dimer interface [polypeptide binding]; other site
552536008395	conserved gate region; other site
552536008396	putative PBP binding loops; other site
552536008397	ABC-ATPase subunit interface; other site
552536008398	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552536008399	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
552536008400	putative NAD(P) binding site [chemical binding]; other site
552536008401	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
552536008402	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536008403	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536008404	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
552536008405	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
552536008406	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
552536008407	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
552536008408	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
552536008409	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
552536008410	beta-phosphoglucomutase; Region: bPGM; TIGR01990
552536008411	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536008412	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008413	motif II; other site
552536008414	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552536008415	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
552536008416	catalytic residues [active]
552536008417	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
552536008418	dimer interface [polypeptide binding]; other site
552536008419	FMN binding site [chemical binding]; other site
552536008420	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552536008421	MarR family; Region: MarR_2; pfam12802
552536008422	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008423	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552536008424	putative substrate translocation pore; other site
552536008425	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
552536008426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536008427	catalytic residue [active]
552536008428	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
552536008429	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
552536008430	putative ligand binding site [chemical binding]; other site
552536008431	putative NAD binding site [chemical binding]; other site
552536008432	putative catalytic site [active]
552536008433	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
552536008434	L-serine binding site [chemical binding]; other site
552536008435	ACT domain interface; other site
552536008436	Uncharacterized conserved protein [Function unknown]; Region: COG4198
552536008437	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
552536008438	Abi-like protein; Region: Abi_2; pfam07751
552536008439	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
552536008440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
552536008441	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
552536008442	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
552536008443	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
552536008444	metal binding site [ion binding]; metal-binding site
552536008445	dimer interface [polypeptide binding]; other site
552536008446	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
552536008447	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
552536008448	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
552536008449	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
552536008450	metal binding site [ion binding]; metal-binding site
552536008451	dimer interface [polypeptide binding]; other site
552536008452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008453	D-galactonate transporter; Region: 2A0114; TIGR00893
552536008454	putative substrate translocation pore; other site
552536008455	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
552536008456	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
552536008457	NADP binding site [chemical binding]; other site
552536008458	homodimer interface [polypeptide binding]; other site
552536008459	active site
552536008460	substrate binding site [chemical binding]; other site
552536008461	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536008462	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536008463	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
552536008464	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
552536008465	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
552536008466	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
552536008467	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
552536008468	trmE is a tRNA modification GTPase; Region: trmE; cd04164
552536008469	G1 box; other site
552536008470	GTP/Mg2+ binding site [chemical binding]; other site
552536008471	Switch I region; other site
552536008472	G2 box; other site
552536008473	Switch II region; other site
552536008474	G3 box; other site
552536008475	G4 box; other site
552536008476	G5 box; other site
552536008477	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
552536008478	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
552536008479	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
552536008480	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
552536008481	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
552536008482	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
552536008483	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
552536008484	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
552536008485	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
552536008486	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
552536008487	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
552536008488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552536008489	S-adenosylmethionine binding site [chemical binding]; other site
552536008490	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
552536008491	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
552536008492	putative active site cavity [active]
552536008493	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
552536008494	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
552536008495	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
552536008496	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
552536008497	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
552536008498	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
552536008499	active site
552536008500	P-loop; other site
552536008501	phosphorylation site [posttranslational modification]
552536008502	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
552536008503	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008504	motif II; other site
552536008505	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536008506	active site
552536008507	phosphorylation site [posttranslational modification]
552536008508	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536008509	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536008510	nucleotide binding site [chemical binding]; other site
552536008511	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
552536008512	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
552536008513	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536008514	putative active site [active]
552536008515	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
552536008516	ParB-like nuclease domain; Region: ParBc; pfam02195
552536008517	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536008518	non-specific DNA binding site [nucleotide binding]; other site
552536008519	salt bridge; other site
552536008520	sequence-specific DNA binding site [nucleotide binding]; other site
552536008521	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
552536008522	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
552536008523	P-loop; other site
552536008524	Magnesium ion binding site [ion binding]; other site
552536008525	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
552536008526	Magnesium ion binding site [ion binding]; other site
552536008527	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552536008528	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
552536008529	ParB-like nuclease domain; Region: ParB; smart00470
552536008530	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
552536008531	salt bridge; other site
552536008532	non-specific DNA binding site [nucleotide binding]; other site
552536008533	sequence-specific DNA binding site [nucleotide binding]; other site
552536008534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481
552536008535	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
552536008536	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
552536008537	tetramer interface [polypeptide binding]; other site
552536008538	heme binding pocket [chemical binding]; other site
552536008539	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536008540	HTH domain; Region: HTH_11; pfam08279
552536008541	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536008542	PRD domain; Region: PRD; pfam00874
552536008543	PRD domain; Region: PRD; pfam00874
552536008544	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536008545	active site
552536008546	P-loop; other site
552536008547	phosphorylation site [posttranslational modification]
552536008548	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536008549	active site
552536008550	phosphorylation site [posttranslational modification]
552536008551	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536008552	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
552536008553	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536008554	active site
552536008555	P-loop; other site
552536008556	phosphorylation site [posttranslational modification]
552536008557	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
552536008558	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
552536008559	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
552536008560	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536008561	methionine cluster; other site
552536008562	active site
552536008563	phosphorylation site [posttranslational modification]
552536008564	metal binding site [ion binding]; metal-binding site
552536008565	GTP-binding protein YchF; Reviewed; Region: PRK09601
552536008566	YchF GTPase; Region: YchF; cd01900
552536008567	G1 box; other site
552536008568	GTP/Mg2+ binding site [chemical binding]; other site
552536008569	Switch I region; other site
552536008570	G2 box; other site
552536008571	Switch II region; other site
552536008572	G3 box; other site
552536008573	G4 box; other site
552536008574	G5 box; other site
552536008575	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
552536008576	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
552536008577	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
552536008578	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
552536008579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008580	putative substrate translocation pore; other site
552536008581	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
552536008582	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
552536008583	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552536008584	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
552536008585	Walker A/P-loop; other site
552536008586	ATP binding site [chemical binding]; other site
552536008587	Q-loop/lid; other site
552536008588	ABC transporter signature motif; other site
552536008589	Walker B; other site
552536008590	D-loop; other site
552536008591	H-loop/switch region; other site
552536008592	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
552536008593	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
552536008594	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552536008595	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
552536008596	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552536008597	Walker A/P-loop; other site
552536008598	ATP binding site [chemical binding]; other site
552536008599	Q-loop/lid; other site
552536008600	ABC transporter signature motif; other site
552536008601	Walker B; other site
552536008602	D-loop; other site
552536008603	H-loop/switch region; other site
552536008604	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552536008605	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
552536008606	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
552536008607	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
552536008608	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536008609	putative active site [active]
552536008610	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536008611	methionine cluster; other site
552536008612	active site
552536008613	phosphorylation site [posttranslational modification]
552536008614	metal binding site [ion binding]; metal-binding site
552536008615	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552536008616	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552536008617	nucleotide binding site [chemical binding]; other site
552536008618	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536008619	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536008620	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536008621	active site
552536008622	P-loop; other site
552536008623	phosphorylation site [posttranslational modification]
552536008624	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
552536008625	beta-galactosidase; Region: BGL; TIGR03356
552536008626	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
552536008627	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536008628	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536008629	ABC transporter; Region: ABC_tran_2; pfam12848
552536008630	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552536008631	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
552536008632	putative ADP-ribose binding site [chemical binding]; other site
552536008633	putative active site [active]
552536008634	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
552536008635	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
552536008636	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
552536008637	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
552536008638	active site
552536008639	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
552536008640	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552536008641	ATP binding site [chemical binding]; other site
552536008642	putative Mg++ binding site [ion binding]; other site
552536008643	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552536008644	nucleotide binding region [chemical binding]; other site
552536008645	ATP-binding site [chemical binding]; other site
552536008646	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
552536008647	HRDC domain; Region: HRDC; pfam00570
552536008648	DNA topoisomerase III; Provisional; Region: PRK07726
552536008649	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
552536008650	active site
552536008651	putative interdomain interaction site [polypeptide binding]; other site
552536008652	putative metal-binding site [ion binding]; other site
552536008653	putative nucleotide binding site [chemical binding]; other site
552536008654	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
552536008655	domain I; other site
552536008656	DNA binding groove [nucleotide binding]
552536008657	phosphate binding site [ion binding]; other site
552536008658	domain II; other site
552536008659	domain III; other site
552536008660	nucleotide binding site [chemical binding]; other site
552536008661	catalytic site [active]
552536008662	domain IV; other site
552536008663	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
552536008664	Predicted acyl esterases [General function prediction only]; Region: COG2936
552536008665	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
552536008666	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
552536008667	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
552536008668	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
552536008669	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
552536008670	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
552536008671	RHS Repeat; Region: RHS_repeat; pfam05593
552536008672	RHS Repeat; Region: RHS_repeat; pfam05593
552536008673	RHS Repeat; Region: RHS_repeat; pfam05593
552536008674	RHS Repeat; Region: RHS_repeat; pfam05593
552536008675	RHS Repeat; Region: RHS_repeat; pfam05593
552536008676	RHS Repeat; Region: RHS_repeat; pfam05593
552536008677	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
552536008678	RHS Repeat; Region: RHS_repeat; pfam05593
552536008679	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
552536008680	RHS Repeat; Region: RHS_repeat; pfam05593
552536008681	RHS Repeat; Region: RHS_repeat; pfam05593
552536008682	RHS Repeat; Region: RHS_repeat; cl11982
552536008683	RHS Repeat; Region: RHS_repeat; cl11982
552536008684	RHS Repeat; Region: RHS_repeat; pfam05593
552536008685	RHS Repeat; Region: RHS_repeat; pfam05593
552536008686	RHS Repeat; Region: RHS_repeat; pfam05593
552536008687	RHS Repeat; Region: RHS_repeat; pfam05593
552536008688	RHS Repeat; Region: RHS_repeat; pfam05593
552536008689	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
552536008690	RHS Repeat; Region: RHS_repeat; pfam05593
552536008691	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
552536008692	RHS Repeat; Region: RHS_repeat; pfam05593
552536008693	RHS Repeat; Region: RHS_repeat; pfam05593
552536008694	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
552536008695	RHS Repeat; Region: RHS_repeat; pfam05593
552536008696	RHS Repeat; Region: RHS_repeat; cl11982
552536008697	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
552536008698	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536008699	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536008700	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536008701	Walker A/P-loop; other site
552536008702	ATP binding site [chemical binding]; other site
552536008703	Q-loop/lid; other site
552536008704	ABC transporter signature motif; other site
552536008705	Walker B; other site
552536008706	D-loop; other site
552536008707	H-loop/switch region; other site
552536008708	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536008709	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536008710	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536008711	Walker A/P-loop; other site
552536008712	ATP binding site [chemical binding]; other site
552536008713	Q-loop/lid; other site
552536008714	ABC transporter signature motif; other site
552536008715	Walker B; other site
552536008716	D-loop; other site
552536008717	H-loop/switch region; other site
552536008718	aminodeoxychorismate synthase; Provisional; Region: PRK07508
552536008719	chorismate binding enzyme; Region: Chorismate_bind; cl10555
552536008720	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
552536008721	substrate-cofactor binding pocket; other site
552536008722	homodimer interface [polypeptide binding]; other site
552536008723	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
552536008724	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552536008725	catalytic residue [active]
552536008726	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
552536008727	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
552536008728	glutamine binding [chemical binding]; other site
552536008729	catalytic triad [active]
552536008730	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
552536008731	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
552536008732	seryl-tRNA synthetase; Provisional; Region: PRK05431
552536008733	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
552536008734	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
552536008735	dimer interface [polypeptide binding]; other site
552536008736	active site
552536008737	motif 1; other site
552536008738	motif 2; other site
552536008739	motif 3; other site
552536008740	TfoX C-terminal domain; Region: TfoX_C; pfam04994
552536008741	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552536008742	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536008743	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536008744	Walker A/P-loop; other site
552536008745	ATP binding site [chemical binding]; other site
552536008746	Q-loop/lid; other site
552536008747	ABC transporter signature motif; other site
552536008748	Walker B; other site
552536008749	D-loop; other site
552536008750	H-loop/switch region; other site
552536008751	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552536008752	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
552536008753	ligand binding site [chemical binding]; other site
552536008754	flexible hinge region; other site
552536008755	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
552536008756	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
552536008757	active site
552536008758	intersubunit interactions; other site
552536008759	catalytic residue [active]
552536008760	Variant SH3 domain; Region: SH3_2; pfam07653
552536008761	Variant SH3 domain; Region: SH3_2; pfam07653
552536008762	peptide ligand binding site [polypeptide binding]; other site
552536008763	drug efflux system protein MdtG; Provisional; Region: PRK09874
552536008764	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552536008765	putative substrate translocation pore; other site
552536008766	Pathogenicity locus; Region: Cdd1; pfam11731
552536008767	NAD-dependent deacetylase; Provisional; Region: PRK00481
552536008768	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
552536008769	NAD+ binding site [chemical binding]; other site
552536008770	substrate binding site [chemical binding]; other site
552536008771	putative Zn binding site [ion binding]; other site
552536008772	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
552536008773	Domain of unknown function DUF21; Region: DUF21; pfam01595
552536008774	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
552536008775	Transporter associated domain; Region: CorC_HlyC; pfam03471
552536008776	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552536008777	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552536008778	DNA binding site [nucleotide binding]
552536008779	domain linker motif; other site
552536008780	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
552536008781	putative dimerization interface [polypeptide binding]; other site
552536008782	putative ligand binding site [chemical binding]; other site
552536008783	glycerate kinase; Region: TIGR00045
552536008784	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
552536008785	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
552536008786	active site
552536008787	homodimer interface [polypeptide binding]; other site
552536008788	catalytic site [active]
552536008789	alpha-mannosidase; Provisional; Region: PRK09819
552536008790	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
552536008791	active site
552536008792	metal binding site [ion binding]; metal-binding site
552536008793	catalytic site [active]
552536008794	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
552536008795	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
552536008796	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536008797	active site
552536008798	phosphorylation site [posttranslational modification]
552536008799	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
552536008800	active site
552536008801	P-loop; other site
552536008802	phosphorylation site [posttranslational modification]
552536008803	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
552536008804	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
552536008805	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
552536008806	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536008807	putative active site [active]
552536008808	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
552536008809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008810	active site
552536008811	motif I; other site
552536008812	motif II; other site
552536008813	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
552536008814	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536008815	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536008816	DNA binding residues [nucleotide binding]
552536008817	putative dimer interface [polypeptide binding]; other site
552536008818	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
552536008819	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
552536008820	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552536008821	MarR family; Region: MarR; pfam01047
552536008822	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
552536008823	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
552536008824	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
552536008825	dimer interface [polypeptide binding]; other site
552536008826	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
552536008827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536008828	Coenzyme A binding pocket [chemical binding]; other site
552536008829	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
552536008830	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552536008831	DNA binding residues [nucleotide binding]
552536008832	drug binding residues [chemical binding]; other site
552536008833	dimer interface [polypeptide binding]; other site
552536008834	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
552536008835	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
552536008836	active site
552536008837	trimer interface [polypeptide binding]; other site
552536008838	allosteric site; other site
552536008839	active site lid [active]
552536008840	hexamer (dimer of trimers) interface [polypeptide binding]; other site
552536008841	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
552536008842	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
552536008843	active site
552536008844	acyl-activating enzyme (AAE) consensus motif; other site
552536008845	putative CoA binding site [chemical binding]; other site
552536008846	AMP binding site [chemical binding]; other site
552536008847	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
552536008848	nucleoside/Zn binding site; other site
552536008849	dimer interface [polypeptide binding]; other site
552536008850	catalytic motif [active]
552536008851	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
552536008852	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
552536008853	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
552536008854	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
552536008855	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
552536008856	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536008857	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552536008858	Walker A/P-loop; other site
552536008859	ATP binding site [chemical binding]; other site
552536008860	Q-loop/lid; other site
552536008861	ABC transporter signature motif; other site
552536008862	Walker B; other site
552536008863	D-loop; other site
552536008864	H-loop/switch region; other site
552536008865	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
552536008866	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552536008867	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
552536008868	Walker A/P-loop; other site
552536008869	ATP binding site [chemical binding]; other site
552536008870	Q-loop/lid; other site
552536008871	ABC transporter signature motif; other site
552536008872	Walker B; other site
552536008873	D-loop; other site
552536008874	H-loop/switch region; other site
552536008875	SH3-like domain; Region: SH3_8; pfam13457
552536008876	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
552536008877	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
552536008878	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
552536008879	N- and C-terminal domain interface [polypeptide binding]; other site
552536008880	active site
552536008881	catalytic site [active]
552536008882	metal binding site [ion binding]; metal-binding site
552536008883	carbohydrate binding site [chemical binding]; other site
552536008884	ATP binding site [chemical binding]; other site
552536008885	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536008886	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536008887	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
552536008888	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
552536008889	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
552536008890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536008891	Walker A motif; other site
552536008892	ATP binding site [chemical binding]; other site
552536008893	Walker B motif; other site
552536008894	arginine finger; other site
552536008895	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
552536008896	hypothetical protein; Validated; Region: PRK00153
552536008897	recombination protein RecR; Reviewed; Region: recR; PRK00076
552536008898	RecR protein; Region: RecR; pfam02132
552536008899	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
552536008900	putative active site [active]
552536008901	putative metal-binding site [ion binding]; other site
552536008902	tetramer interface [polypeptide binding]; other site
552536008903	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
552536008904	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536008905	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536008906	active site
552536008907	catalytic tetrad [active]
552536008908	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
552536008909	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552536008910	active site
552536008911	motif I; other site
552536008912	motif II; other site
552536008913	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552536008914	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
552536008915	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
552536008916	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536008917	putative active site [active]
552536008918	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
552536008919	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
552536008920	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
552536008921	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
552536008922	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
552536008923	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
552536008924	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
552536008925	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552536008926	catalytic residue [active]
552536008927	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
552536008928	thymidylate kinase; Validated; Region: tmk; PRK00698
552536008929	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
552536008930	TMP-binding site; other site
552536008931	ATP-binding site [chemical binding]; other site
552536008932	Protein of unknown function (DUF970); Region: DUF970; pfam06153
552536008933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552536008934	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
552536008935	Walker A motif; other site
552536008936	ATP binding site [chemical binding]; other site
552536008937	Walker B motif; other site
552536008938	arginine finger; other site
552536008939	autolysin; Reviewed; Region: PRK06347
552536008940	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536008941	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536008942	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536008943	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536008944	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552536008945	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552536008946	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552536008947	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
552536008948	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
552536008949	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536008950	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
552536008951	Soluble P-type ATPase [General function prediction only]; Region: COG4087
552536008952	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
552536008953	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
552536008954	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
552536008955	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
552536008956	methionine cluster; other site
552536008957	active site
552536008958	phosphorylation site [posttranslational modification]
552536008959	metal binding site [ion binding]; metal-binding site
552536008960	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
552536008961	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
552536008962	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
552536008963	active site
552536008964	P-loop; other site
552536008965	phosphorylation site [posttranslational modification]
552536008966	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
552536008967	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
552536008968	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552536008969	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
552536008970	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
552536008971	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
552536008972	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
552536008973	Ligand Binding Site [chemical binding]; other site
552536008974	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
552536008975	GAF domain; Region: GAF_3; pfam13492
552536008976	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552536008977	dimer interface [polypeptide binding]; other site
552536008978	phosphorylation site [posttranslational modification]
552536008979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552536008980	ATP binding site [chemical binding]; other site
552536008981	Mg2+ binding site [ion binding]; other site
552536008982	G-X-G motif; other site
552536008983	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552536008984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552536008985	active site
552536008986	phosphorylation site [posttranslational modification]
552536008987	intermolecular recognition site; other site
552536008988	dimerization interface [polypeptide binding]; other site
552536008989	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552536008990	DNA binding site [nucleotide binding]
552536008991	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
552536008992	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
552536008993	DNA polymerase IV; Reviewed; Region: PRK03103
552536008994	active site
552536008995	DNA binding site [nucleotide binding]
552536008996	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
552536008997	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552536008998	Ligand Binding Site [chemical binding]; other site
552536008999	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
552536009000	Predicted membrane protein [Function unknown]; Region: COG4905
552536009001	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
552536009002	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536009003	PRD domain; Region: PRD; pfam00874
552536009004	PRD domain; Region: PRD; pfam00874
552536009005	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536009006	active site
552536009007	P-loop; other site
552536009008	phosphorylation site [posttranslational modification]
552536009009	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536009010	active site
552536009011	phosphorylation site [posttranslational modification]
552536009012	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536009013	active site
552536009014	phosphorylation site [posttranslational modification]
552536009015	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
552536009016	active site
552536009017	P-loop; other site
552536009018	phosphorylation site [posttranslational modification]
552536009019	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
552536009020	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
552536009021	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552536009022	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
552536009023	putative NAD(P) binding site [chemical binding]; other site
552536009024	catalytic Zn binding site [ion binding]; other site
552536009025	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552536009026	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
552536009027	putative NAD(P) binding site [chemical binding]; other site
552536009028	catalytic Zn binding site [ion binding]; other site
552536009029	structural Zn binding site [ion binding]; other site
552536009030	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
552536009031	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552536009032	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552536009033	substrate binding site [chemical binding]; other site
552536009034	hexamer interface [polypeptide binding]; other site
552536009035	metal binding site [ion binding]; metal-binding site
552536009036	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
552536009037	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
552536009038	TPP-binding site [chemical binding]; other site
552536009039	dimer interface [polypeptide binding]; other site
552536009040	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552536009041	PYR/PP interface [polypeptide binding]; other site
552536009042	dimer interface [polypeptide binding]; other site
552536009043	TPP binding site [chemical binding]; other site
552536009044	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552536009045	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552536009046	substrate binding site [chemical binding]; other site
552536009047	hexamer interface [polypeptide binding]; other site
552536009048	metal binding site [ion binding]; metal-binding site
552536009049	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552536009050	Coenzyme A binding pocket [chemical binding]; other site
552536009051	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
552536009052	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552536009053	Zn2+ binding site [ion binding]; other site
552536009054	Mg2+ binding site [ion binding]; other site
552536009055	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
552536009056	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
552536009057	S17 interaction site [polypeptide binding]; other site
552536009058	S8 interaction site; other site
552536009059	16S rRNA interaction site [nucleotide binding]; other site
552536009060	streptomycin interaction site [chemical binding]; other site
552536009061	23S rRNA interaction site [nucleotide binding]; other site
552536009062	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
552536009063	30S ribosomal protein S7; Validated; Region: PRK05302
552536009064	elongation factor G; Reviewed; Region: PRK00007
552536009065	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
552536009066	G1 box; other site
552536009067	putative GEF interaction site [polypeptide binding]; other site
552536009068	GTP/Mg2+ binding site [chemical binding]; other site
552536009069	Switch I region; other site
552536009070	G2 box; other site
552536009071	G3 box; other site
552536009072	Switch II region; other site
552536009073	G4 box; other site
552536009074	G5 box; other site
552536009075	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
552536009076	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
552536009077	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
552536009078	elongation factor Tu; Reviewed; Region: PRK00049
552536009079	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
552536009080	G1 box; other site
552536009081	GEF interaction site [polypeptide binding]; other site
552536009082	GTP/Mg2+ binding site [chemical binding]; other site
552536009083	Switch I region; other site
552536009084	G2 box; other site
552536009085	G3 box; other site
552536009086	Switch II region; other site
552536009087	G4 box; other site
552536009088	G5 box; other site
552536009089	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
552536009090	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
552536009091	Antibiotic Binding Site [chemical binding]; other site
552536009092	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
552536009093	Mga helix-turn-helix domain; Region: Mga; pfam05043
552536009094	PRD domain; Region: PRD; pfam00874
552536009095	PRD domain; Region: PRD; pfam00874
552536009096	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
552536009097	active site
552536009098	P-loop; other site
552536009099	phosphorylation site [posttranslational modification]
552536009100	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536009101	active site
552536009102	phosphorylation site [posttranslational modification]
552536009103	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
552536009104	active site
552536009105	phosphorylation site [posttranslational modification]
552536009106	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
552536009107	active site
552536009108	P-loop; other site
552536009109	phosphorylation site [posttranslational modification]
552536009110	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
552536009111	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
552536009112	active site
552536009113	substrate binding pocket [chemical binding]; other site
552536009114	homodimer interaction site [polypeptide binding]; other site
552536009115	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
552536009116	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
552536009117	hypothetical protein; Provisional; Region: PRK02947
552536009118	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
552536009119	putative active site [active]
552536009120	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
552536009121	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
552536009122	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
552536009123	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
552536009124	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
552536009125	active site
552536009126	metal binding site [ion binding]; metal-binding site
552536009127	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
552536009128	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
552536009129	substrate binding pocket [chemical binding]; other site
552536009130	chain length determination region; other site
552536009131	substrate-Mg2+ binding site; other site
552536009132	catalytic residues [active]
552536009133	aspartate-rich region 1; other site
552536009134	active site lid residues [active]
552536009135	aspartate-rich region 2; other site
552536009136	Predicted membrane protein [Function unknown]; Region: COG4769
552536009137	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
552536009138	trimer interface [polypeptide binding]; other site
552536009139	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
552536009140	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552536009141	Predicted membrane protein [Function unknown]; Region: COG2259
552536009142	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
552536009143	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
552536009144	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
552536009145	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
552536009146	ApbE family; Region: ApbE; pfam02424
552536009147	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
552536009148	UbiA prenyltransferase family; Region: UbiA; pfam01040
552536009149	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
552536009150	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
552536009151	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
552536009152	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
552536009153	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
552536009154	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
552536009155	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
552536009156	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
552536009157	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
552536009158	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
552536009159	putative translocon binding site; other site
552536009160	protein-rRNA interface [nucleotide binding]; other site
552536009161	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
552536009162	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
552536009163	G-X-X-G motif; other site
552536009164	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
552536009165	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
552536009166	23S rRNA interface [nucleotide binding]; other site
552536009167	5S rRNA interface [nucleotide binding]; other site
552536009168	putative antibiotic binding site [chemical binding]; other site
552536009169	L25 interface [polypeptide binding]; other site
552536009170	L27 interface [polypeptide binding]; other site
552536009171	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
552536009172	23S rRNA interface [nucleotide binding]; other site
552536009173	putative translocon interaction site; other site
552536009174	signal recognition particle (SRP54) interaction site; other site
552536009175	L23 interface [polypeptide binding]; other site
552536009176	trigger factor interaction site; other site
552536009177	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
552536009178	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
552536009179	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
552536009180	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
552536009181	RNA binding site [nucleotide binding]; other site
552536009182	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
552536009183	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
552536009184	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
552536009185	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
552536009186	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
552536009187	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
552536009188	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
552536009189	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
552536009190	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
552536009191	5S rRNA interface [nucleotide binding]; other site
552536009192	L27 interface [polypeptide binding]; other site
552536009193	23S rRNA interface [nucleotide binding]; other site
552536009194	L5 interface [polypeptide binding]; other site
552536009195	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
552536009196	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
552536009197	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
552536009198	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
552536009199	23S rRNA binding site [nucleotide binding]; other site
552536009200	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
552536009201	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
552536009202	SecY translocase; Region: SecY; pfam00344
552536009203	adenylate kinase; Reviewed; Region: adk; PRK00279
552536009204	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
552536009205	AMP-binding site [chemical binding]; other site
552536009206	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
552536009207	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
552536009208	rRNA binding site [nucleotide binding]; other site
552536009209	predicted 30S ribosome binding site; other site
552536009210	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
552536009211	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
552536009212	30S ribosomal protein S13; Region: bact_S13; TIGR03631
552536009213	30S ribosomal protein S11; Validated; Region: PRK05309
552536009214	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
552536009215	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
552536009216	alphaNTD - beta interaction site [polypeptide binding]; other site
552536009217	alphaNTD homodimer interface [polypeptide binding]; other site
552536009218	alphaNTD - beta' interaction site [polypeptide binding]; other site
552536009219	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
552536009220	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
552536009221	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
552536009222	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
552536009223	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
552536009224	MgtC family; Region: MgtC; pfam02308
552536009225	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
552536009226	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552536009227	Walker A/P-loop; other site
552536009228	ATP binding site [chemical binding]; other site
552536009229	Q-loop/lid; other site
552536009230	ABC transporter signature motif; other site
552536009231	Walker B; other site
552536009232	D-loop; other site
552536009233	H-loop/switch region; other site
552536009234	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
552536009235	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552536009236	Walker A/P-loop; other site
552536009237	ATP binding site [chemical binding]; other site
552536009238	Q-loop/lid; other site
552536009239	ABC transporter signature motif; other site
552536009240	Walker B; other site
552536009241	D-loop; other site
552536009242	H-loop/switch region; other site
552536009243	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
552536009244	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
552536009245	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
552536009246	dimerization interface 3.5A [polypeptide binding]; other site
552536009247	active site
552536009248	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
552536009249	23S rRNA interface [nucleotide binding]; other site
552536009250	L3 interface [polypeptide binding]; other site
552536009251	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
552536009252	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
552536009253	Int/Topo IB signature motif; other site
552536009254	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
552536009255	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552536009256	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536009257	sequence-specific DNA binding site [nucleotide binding]; other site
552536009258	salt bridge; other site
552536009259	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552536009260	non-specific DNA binding site [nucleotide binding]; other site
552536009261	salt bridge; other site
552536009262	sequence-specific DNA binding site [nucleotide binding]; other site
552536009263	AntA/AntB antirepressor; Region: AntA; pfam08346
552536009264	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
552536009265	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
552536009266	Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377
552536009267	Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723
552536009268	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
552536009269	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
552536009270	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
552536009271	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
552536009272	YopX protein; Region: YopX; cl09859
552536009273	chaperone protein DnaJ; Provisional; Region: PRK14291
552536009274	Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961
552536009275	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
552536009276	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
552536009277	dimer interface [polypeptide binding]; other site
552536009278	ssDNA binding site [nucleotide binding]; other site
552536009279	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552536009280	NUMOD4 motif; Region: NUMOD4; pfam07463
552536009281	HNH endonuclease; Region: HNH_3; pfam13392
552536009282	NUMOD1 domain; Region: NUMOD1; pfam07453
552536009283	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
552536009284	Protein of unknown function (DUF2481); Region: DUF2481; pfam10654
552536009285	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
552536009286	SprT-like family; Region: SprT-like; pfam10263
552536009287	Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728
552536009288	Phage terminase large subunit; Region: Terminase_3; cl12054
552536009289	Terminase-like family; Region: Terminase_6; pfam03237
552536009290	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
552536009291	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
552536009292	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
552536009293	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
552536009294	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
552536009295	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
552536009296	Minor capsid protein; Region: Minor_capsid_1; pfam10665
552536009297	Minor capsid protein; Region: Minor_capsid_2; pfam11114
552536009298	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
552536009299	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
552536009300	Phage protein Gp14; Region: Phage_Gp14; pfam10666
552536009301	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
552536009302	tape measure domain; Region: tape_meas_nterm; TIGR02675
552536009303	Phage tail protein; Region: Sipho_tail; pfam05709
552536009304	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
552536009305	putative pectinesterase; Region: PLN02432; cl01911
552536009306	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
552536009307	Bacteriophage holin; Region: Phage_holin_1; pfam04531
552536009308	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
552536009309	active site
552536009310	metal binding site [ion binding]; metal-binding site
552536009311	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
552536009312	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
552536009313	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
552536009314	DNA binding residues [nucleotide binding]
552536009315	putative dimer interface [polypeptide binding]; other site
552536009316	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552536009317	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552536009318	active site
552536009319	catalytic tetrad [active]
552536009320	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
552536009321	SH3-like domain; Region: SH3_8; pfam13457
552536009322	SH3-like domain; Region: SH3_8; pfam13457
552536009323	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
552536009324	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
552536009325	Walker A motif; other site