-- dump date   	20140619_132707
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
393130000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
393130000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
393130000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130000004	Walker A motif; other site
393130000005	ATP binding site [chemical binding]; other site
393130000006	Walker B motif; other site
393130000007	arginine finger; other site
393130000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
393130000009	DnaA box-binding interface [nucleotide binding]; other site
393130000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
393130000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
393130000012	putative DNA binding surface [nucleotide binding]; other site
393130000013	dimer interface [polypeptide binding]; other site
393130000014	beta-clamp/clamp loader binding surface; other site
393130000015	beta-clamp/translesion DNA polymerase binding surface; other site
393130000016	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393130000017	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
393130000018	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
393130000019	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
393130000020	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
393130000021	Walker A/P-loop; other site
393130000022	ATP binding site [chemical binding]; other site
393130000023	Q-loop/lid; other site
393130000024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130000025	ABC transporter signature motif; other site
393130000026	Walker B; other site
393130000027	D-loop; other site
393130000028	H-loop/switch region; other site
393130000029	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
393130000030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130000031	Mg2+ binding site [ion binding]; other site
393130000032	G-X-G motif; other site
393130000033	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
393130000034	anchoring element; other site
393130000035	dimer interface [polypeptide binding]; other site
393130000036	ATP binding site [chemical binding]; other site
393130000037	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
393130000038	active site
393130000039	putative metal-binding site [ion binding]; other site
393130000040	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
393130000041	DNA gyrase subunit A; Validated; Region: PRK05560
393130000042	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
393130000043	CAP-like domain; other site
393130000044	active site
393130000045	primary dimer interface [polypeptide binding]; other site
393130000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130000051	cardiolipin synthetase; Reviewed; Region: PRK12452
393130000052	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
393130000053	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
393130000054	putative active site [active]
393130000055	catalytic site [active]
393130000056	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
393130000057	putative active site [active]
393130000058	catalytic site [active]
393130000059	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393130000060	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130000061	Coenzyme A binding pocket [chemical binding]; other site
393130000062	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
393130000063	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393130000064	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393130000065	diphosphomevalonate decarboxylase; Region: PLN02407
393130000066	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
393130000067	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
393130000068	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393130000069	cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432
393130000070	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
393130000071	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
393130000072	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
393130000073	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
393130000074	D-pathway; other site
393130000075	Putative ubiquinol binding site [chemical binding]; other site
393130000076	Low-spin heme (heme b) binding site [chemical binding]; other site
393130000077	Putative water exit pathway; other site
393130000078	Binuclear center (heme o3/CuB) [ion binding]; other site
393130000079	K-pathway; other site
393130000080	Putative proton exit pathway; other site
393130000081	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
393130000082	Subunit I/III interface [polypeptide binding]; other site
393130000083	Subunit III/IV interface [polypeptide binding]; other site
393130000084	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
393130000085	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
393130000086	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
393130000087	putative active site [active]
393130000088	putative metal binding site [ion binding]; other site
393130000089	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
393130000090	beta-galactosidase; Region: BGL; TIGR03356
393130000091	Bacterial SH3 domain; Region: SH3_3; pfam08239
393130000092	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
393130000093	putative active site [active]
393130000094	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130000095	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130000096	DNA-binding site [nucleotide binding]; DNA binding site
393130000097	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393130000098	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130000099	active site
393130000100	active pocket/dimerization site; other site
393130000101	phosphorylation site [posttranslational modification]
393130000102	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393130000103	active site
393130000104	phosphorylation site [posttranslational modification]
393130000105	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
393130000106	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
393130000107	hypothetical protein; Provisional; Region: PRK02947
393130000108	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130000109	putative active site [active]
393130000110	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
393130000111	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
393130000112	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130000113	active site turn [active]
393130000114	phosphorylation site [posttranslational modification]
393130000115	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130000116	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393130000117	HPr interaction site; other site
393130000118	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130000119	active site
393130000120	phosphorylation site [posttranslational modification]
393130000121	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
393130000122	putative dimer interface [polypeptide binding]; other site
393130000123	catalytic triad [active]
393130000124	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
393130000125	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130000126	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130000127	Walker A/P-loop; other site
393130000128	ATP binding site [chemical binding]; other site
393130000129	Q-loop/lid; other site
393130000130	ABC transporter signature motif; other site
393130000131	Walker B; other site
393130000132	D-loop; other site
393130000133	H-loop/switch region; other site
393130000134	Protein of unknown function (DUF2705); Region: DUF2705; pfam10920
393130000135	Protein of unknown function (DUF2712); Region: DUF2712; pfam10916
393130000136	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130000137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000138	active site
393130000139	motif I; other site
393130000140	motif II; other site
393130000141	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000142	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130000143	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130000144	DNA binding site [nucleotide binding]
393130000145	domain linker motif; other site
393130000146	Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299
393130000147	dimerization interface [polypeptide binding]; other site
393130000148	putative ligand binding site [chemical binding]; other site
393130000149	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130000150	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130000151	nucleotide binding site [chemical binding]; other site
393130000152	Butyrate kinase [Energy production and conversion]; Region: COG3426
393130000153	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
393130000154	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130000155	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130000156	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393130000157	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393130000158	dimer interface [polypeptide binding]; other site
393130000159	active site
393130000160	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393130000161	dimer interface [polypeptide binding]; other site
393130000162	active site
393130000163	putrescine carbamoyltransferase; Provisional; Region: PRK02255
393130000164	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393130000165	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393130000166	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
393130000167	Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468
393130000168	agmatine deiminase; Provisional; Region: PRK13551
393130000169	agmatine deiminase; Region: agmatine_aguA; TIGR03380
393130000170	carbamate kinase; Reviewed; Region: PRK12686
393130000171	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
393130000172	putative substrate binding site [chemical binding]; other site
393130000173	nucleotide binding site [chemical binding]; other site
393130000174	nucleotide binding site [chemical binding]; other site
393130000175	homodimer interface [polypeptide binding]; other site
393130000176	agmatine deiminase; Provisional; Region: PRK13551
393130000177	agmatine deiminase; Region: agmatine_aguA; TIGR03380
393130000178	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130000179	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130000180	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130000181	putative active site [active]
393130000182	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
393130000183	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393130000184	arginine deiminase; Provisional; Region: PRK01388
393130000185	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
393130000186	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393130000187	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393130000188	dimer interface [polypeptide binding]; other site
393130000189	ssDNA binding site [nucleotide binding]; other site
393130000190	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130000191	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
393130000192	Predicted membrane protein [Function unknown]; Region: COG3212
393130000193	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393130000194	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393130000195	putative accessory gene regulator protein; Provisional; Region: PRK01100
393130000196	Staphylococcal AgrD protein; Region: AgrD; cl05477
393130000197	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
393130000198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130000199	ATP binding site [chemical binding]; other site
393130000200	Mg2+ binding site [ion binding]; other site
393130000201	G-X-G motif; other site
393130000202	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
393130000203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130000204	active site
393130000205	phosphorylation site [posttranslational modification]
393130000206	intermolecular recognition site; other site
393130000207	LytTr DNA-binding domain; Region: LytTR; pfam04397
393130000208	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
393130000209	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
393130000210	DHH family; Region: DHH; pfam01368
393130000211	DHHA1 domain; Region: DHHA1; pfam02272
393130000212	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
393130000213	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
393130000214	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
393130000215	replicative DNA helicase; Provisional; Region: PRK05748
393130000216	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
393130000217	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
393130000218	Walker A motif; other site
393130000219	ATP binding site [chemical binding]; other site
393130000220	Walker B motif; other site
393130000221	DNA binding loops [nucleotide binding]
393130000222	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
393130000223	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
393130000224	GDP-binding site [chemical binding]; other site
393130000225	ACT binding site; other site
393130000226	IMP binding site; other site
393130000227	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842
393130000228	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393130000229	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
393130000230	Predicted membrane protein [Function unknown]; Region: COG1511
393130000231	Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858
393130000232	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
393130000233	Uncharacterized small protein [Function unknown]; Region: COG5417
393130000234	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
393130000235	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
393130000236	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
393130000237	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
393130000238	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393130000239	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393130000240	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393130000241	Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013
393130000242	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
393130000243	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
393130000244	tetramer interface [polypeptide binding]; other site
393130000245	active site
393130000246	Mg2+/Mn2+ binding site [ion binding]; other site
393130000247	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
393130000248	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
393130000249	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393130000250	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393130000251	DNA binding site [nucleotide binding]
393130000252	active site
393130000253	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393130000254	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393130000255	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
393130000256	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
393130000257	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178
393130000258	putative ligand binding site [chemical binding]; other site
393130000259	putative NAD binding site [chemical binding]; other site
393130000260	catalytic site [active]
393130000261	LXG domain of WXG superfamily; Region: LXG; pfam04740
393130000262	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130000263	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393130000264	DNA binding residues [nucleotide binding]
393130000265	putative dimer interface [polypeptide binding]; other site
393130000266	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130000267	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130000268	active site
393130000269	catalytic tetrad [active]
393130000270	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000271	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130000272	ATP synthase subunit C; Region: ATP-synt_C; cl00466
393130000273	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
393130000274	F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343
393130000275	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393130000276	Walker A motif; other site
393130000277	ATP binding site [chemical binding]; other site
393130000278	Walker B motif; other site
393130000279	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393130000280	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
393130000281	core domain interface [polypeptide binding]; other site
393130000282	delta subunit interface [polypeptide binding]; other site
393130000283	epsilon subunit interface [polypeptide binding]; other site
393130000284	F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597
393130000285	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393130000286	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
393130000287	alpha subunit interaction interface [polypeptide binding]; other site
393130000288	Walker A motif; other site
393130000289	ATP binding site [chemical binding]; other site
393130000290	Walker B motif; other site
393130000291	inhibitor binding site; inhibition site
393130000292	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393130000293	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823
393130000294	gamma subunit interface [polypeptide binding]; other site
393130000295	epsilon subunit interface [polypeptide binding]; other site
393130000296	LBP interface [polypeptide binding]; other site
393130000297	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000298	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
393130000299	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130000300	active pocket/dimerization site; other site
393130000301	active site
393130000302	phosphorylation site [posttranslational modification]
393130000303	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393130000304	active site
393130000305	phosphorylation site [posttranslational modification]
393130000306	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
393130000307	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
393130000308	Domain of unknown function (DUF956); Region: DUF956; pfam06115
393130000309	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966
393130000310	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130000311	dimerization interface [polypeptide binding]; other site
393130000312	putative DNA binding site [nucleotide binding]; other site
393130000313	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393130000314	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
393130000315	dimer interface [polypeptide binding]; other site
393130000316	FMN binding site [chemical binding]; other site
393130000317	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
393130000318	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
393130000319	active site
393130000320	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
393130000321	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
393130000322	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393130000323	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393130000324	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130000325	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130000326	nucleotide binding site [chemical binding]; other site
393130000327	butyrate kinase; Region: butyr_kinase; TIGR02707
393130000328	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130000329	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130000330	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393130000331	Walker A/P-loop; other site
393130000332	ATP binding site [chemical binding]; other site
393130000333	Q-loop/lid; other site
393130000334	ABC transporter signature motif; other site
393130000335	Walker B; other site
393130000336	D-loop; other site
393130000337	H-loop/switch region; other site
393130000338	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130000339	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130000340	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393130000341	Walker A/P-loop; other site
393130000342	ATP binding site [chemical binding]; other site
393130000343	Q-loop/lid; other site
393130000344	ABC transporter signature motif; other site
393130000345	Walker B; other site
393130000346	D-loop; other site
393130000347	H-loop/switch region; other site
393130000348	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
393130000349	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130000350	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393130000351	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130000352	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
393130000353	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
393130000354	substrate binding pocket [chemical binding]; other site
393130000355	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
393130000356	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393130000357	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000358	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393130000359	ligand binding site [chemical binding]; other site
393130000360	flexible hinge region; other site
393130000361	Domain of unknown function (DUF955); Region: DUF955; pfam06114
393130000362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130000363	non-specific DNA binding site [nucleotide binding]; other site
393130000364	salt bridge; other site
393130000365	sequence-specific DNA binding site [nucleotide binding]; other site
393130000366	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
393130000367	Predicted secreted protein [Function unknown]; Region: COG5437
393130000368	Phage-related protein [Function unknown]; Region: COG5412
393130000369	Phage tail protein; Region: Sipho_tail; pfam05709
393130000370	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
393130000371	Predicted membrane protein [Function unknown]; Region: COG1511
393130000372	Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824
393130000373	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
393130000374	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
393130000375	active site
393130000376	metal binding site [ion binding]; metal-binding site
393130000377	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
393130000378	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
393130000379	putative active site [active]
393130000380	putative metal binding site [ion binding]; other site
393130000381	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
393130000382	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393130000383	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107
393130000384	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
393130000385	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602
393130000386	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
393130000387	active site
393130000388	Uncharacterized conserved protein [Function unknown]; Region: COG3592
393130000389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130000390	Coenzyme A binding pocket [chemical binding]; other site
393130000391	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
393130000392	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
393130000393	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393130000394	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000395	dimer interface [polypeptide binding]; other site
393130000396	conserved gate region; other site
393130000397	putative PBP binding loops; other site
393130000398	ABC-ATPase subunit interface; other site
393130000399	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393130000400	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
393130000401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000402	dimer interface [polypeptide binding]; other site
393130000403	conserved gate region; other site
393130000404	putative PBP binding loops; other site
393130000405	ABC-ATPase subunit interface; other site
393130000406	Protein of unknown function (DUF3130; Region: DUF3130; cl12867
393130000407	LXG domain of WXG superfamily; Region: LXG; pfam04740
393130000408	ATP synthase CF1 alpha subunit; Region: atpA; CHL00059
393130000409	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393130000410	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393130000411	peptide binding site [polypeptide binding]; other site
393130000412	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393130000413	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
393130000414	metal binding site [ion binding]; metal-binding site
393130000415	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
393130000416	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393130000417	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393130000418	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130000419	ABC-ATPase subunit  interface; other site
393130000420	dimer interface [polypeptide binding]; other site
393130000421	putative PBP binding regions; other site
393130000422	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000423	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130000424	ligand binding site [chemical binding]; other site
393130000425	flexible hinge region; other site
393130000426	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
393130000427	DEAD_2; Region: DEAD_2; pfam06733
393130000428	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
393130000429	sugar phosphate phosphatase; Provisional; Region: PRK10513
393130000430	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000431	active site
393130000432	motif I; other site
393130000433	motif II; other site
393130000434	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000435	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393130000436	Collagen binding domain; Region: Collagen_bind; pfam05737
393130000437	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000438	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000439	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000440	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000441	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393130000442	Collagen binding domain; Region: Collagen_bind; pfam05737
393130000443	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000444	Cna protein B-type domain; Region: Cna_B; pfam05738
393130000445	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130000446	DNA polymerase III subunit delta'; Validated; Region: PRK08058
393130000447	DNA polymerase III subunit delta'; Validated; Region: PRK08485
393130000448	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
393130000449	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467
393130000450	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
393130000451	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130000452	S-adenosylmethionine binding site [chemical binding]; other site
393130000453	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
393130000454	GIY-YIG motif/motif A; other site
393130000455	putative active site [active]
393130000456	putative metal binding site [ion binding]; other site
393130000457	Predicted methyltransferases [General function prediction only]; Region: COG0313
393130000458	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
393130000459	putative SAM binding site [chemical binding]; other site
393130000460	putative homodimer interface [polypeptide binding]; other site
393130000461	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
393130000462	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
393130000463	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393130000464	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393130000465	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393130000466	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
393130000467	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393130000468	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130000469	Leucine-rich repeats; other site
393130000470	Substrate binding site [chemical binding]; other site
393130000471	Leucine rich repeat; Region: LRR_8; pfam13855
393130000472	LRR adjacent; Region: LRR_adjacent; pfam08191
393130000473	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130000474	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130000475	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
393130000476	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130000477	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130000478	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393130000479	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
393130000480	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
393130000481	active site
393130000482	HIGH motif; other site
393130000483	KMSKS motif; other site
393130000484	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
393130000485	tRNA binding surface [nucleotide binding]; other site
393130000486	anticodon binding site; other site
393130000487	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
393130000488	dimer interface [polypeptide binding]; other site
393130000489	putative tRNA-binding site [nucleotide binding]; other site
393130000490	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
393130000491	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130000492	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130000493	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
393130000494	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393130000495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000496	dimer interface [polypeptide binding]; other site
393130000497	conserved gate region; other site
393130000498	putative PBP binding loops; other site
393130000499	ABC-ATPase subunit interface; other site
393130000500	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130000501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000502	dimer interface [polypeptide binding]; other site
393130000503	conserved gate region; other site
393130000504	putative PBP binding loops; other site
393130000505	ABC-ATPase subunit interface; other site
393130000506	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393130000507	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130000508	alpha-glucosidase; Provisional; Region: PRK10426
393130000509	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393130000510	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
393130000511	active site
393130000512	catalytic site [active]
393130000513	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393130000514	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393130000515	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
393130000516	trimer interface [polypeptide binding]; other site
393130000517	active site
393130000518	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
393130000519	catalytic site [active]
393130000520	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393130000521	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393130000522	Ca binding site [ion binding]; other site
393130000523	active site
393130000524	catalytic site [active]
393130000525	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
393130000526	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
393130000527	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
393130000528	active site
393130000529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
393130000530	Domain of unknown function (DUF348); Region: DUF348; pfam03990
393130000531	Domain of unknown function (DUF348); Region: DUF348; pfam03990
393130000532	G5 domain; Region: G5; pfam07501
393130000533	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
393130000534	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
393130000535	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
393130000536	putative active site [active]
393130000537	putative metal binding site [ion binding]; other site
393130000538	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
393130000539	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
393130000540	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130000541	S-adenosylmethionine binding site [chemical binding]; other site
393130000542	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
393130000543	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
393130000544	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393130000545	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
393130000546	putative active site [active]
393130000547	YdjC motif; other site
393130000548	Mg binding site [ion binding]; other site
393130000549	putative homodimer interface [polypeptide binding]; other site
393130000550	pur operon repressor; Provisional; Region: PRK09213
393130000551	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
393130000552	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130000553	active site
393130000554	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
393130000555	HlyD family secretion protein; Region: HlyD_3; pfam13437
393130000556	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130000557	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130000558	Walker A/P-loop; other site
393130000559	ATP binding site [chemical binding]; other site
393130000560	Q-loop/lid; other site
393130000561	ABC transporter signature motif; other site
393130000562	Walker B; other site
393130000563	D-loop; other site
393130000564	H-loop/switch region; other site
393130000565	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130000566	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393130000567	FtsX-like permease family; Region: FtsX; pfam02687
393130000568	regulatory protein SpoVG; Reviewed; Region: PRK13259
393130000569	regulatory protein SpoVG; Reviewed; Region: PRK13259
393130000570	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
393130000571	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
393130000572	Substrate binding site; other site
393130000573	Mg++ binding site; other site
393130000574	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
393130000575	active site
393130000576	substrate binding site [chemical binding]; other site
393130000577	CoA binding site [chemical binding]; other site
393130000578	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
393130000579	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
393130000580	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130000581	active site
393130000582	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000583	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130000584	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130000585	Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137
393130000586	active site
393130000587	catalytic site [active]
393130000588	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
393130000589	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
393130000590	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
393130000591	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393130000592	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
393130000593	active site
393130000594	Zn binding site [ion binding]; other site
393130000595	ActA Protein; Region: ActA; pfam05058
393130000596	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
393130000597	Zn binding site [ion binding]; other site
393130000598	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808
393130000599	hypothetical protein; Provisional; Region: PRK01119
393130000600	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
393130000601	A new structural DNA glycosylase; Region: AlkD_like; cd06561
393130000602	active site
393130000603	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
393130000604	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393130000605	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130000606	NAD binding site [chemical binding]; other site
393130000607	dimer interface [polypeptide binding]; other site
393130000608	substrate binding site [chemical binding]; other site
393130000609	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
393130000610	ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731
393130000611	5S rRNA interface [nucleotide binding]; other site
393130000612	CTC domain interface [polypeptide binding]; other site
393130000613	L16 interface [polypeptide binding]; other site
393130000614	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130000615	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130000616	Coenzyme A binding pocket [chemical binding]; other site
393130000617	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
393130000618	putative active site [active]
393130000619	catalytic residue [active]
393130000620	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
393130000621	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
393130000622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130000623	ATP binding site [chemical binding]; other site
393130000624	putative Mg++ binding site [ion binding]; other site
393130000625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130000626	nucleotide binding region [chemical binding]; other site
393130000627	ATP-binding site [chemical binding]; other site
393130000628	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
393130000629	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393130000630	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393130000631	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130000632	RNA binding surface [nucleotide binding]; other site
393130000633	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
393130000634	Septum formation initiator; Region: DivIC; pfam04977
393130000635	hypothetical protein; Provisional; Region: PRK08582
393130000636	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393130000637	RNA binding site [nucleotide binding]; other site
393130000638	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
393130000639	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
393130000640	Ligand Binding Site [chemical binding]; other site
393130000641	TilS substrate C-terminal domain; Region: TilS_C; smart00977
393130000642	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
393130000643	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130000644	active site
393130000645	FtsH Extracellular; Region: FtsH_ext; pfam06480
393130000646	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
393130000647	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130000648	Walker A motif; other site
393130000649	ATP binding site [chemical binding]; other site
393130000650	Walker B motif; other site
393130000651	arginine finger; other site
393130000652	Peptidase family M41; Region: Peptidase_M41; pfam01434
393130000653	pantothenate kinase; Reviewed; Region: PRK13318
393130000654	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
393130000655	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
393130000656	dimerization interface [polypeptide binding]; other site
393130000657	domain crossover interface; other site
393130000658	redox-dependent activation switch; other site
393130000659	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
393130000660	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
393130000661	dimer interface [polypeptide binding]; other site
393130000662	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130000663	catalytic residue [active]
393130000664	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
393130000665	homooctamer interface [polypeptide binding]; other site
393130000666	active site
393130000667	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
393130000668	catalytic center binding site [active]
393130000669	ATP binding site [chemical binding]; other site
393130000670	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
393130000671	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
393130000672	FMN binding site [chemical binding]; other site
393130000673	active site
393130000674	catalytic residues [active]
393130000675	substrate binding site [chemical binding]; other site
393130000676	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
393130000677	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
393130000678	dimer interface [polypeptide binding]; other site
393130000679	putative anticodon binding site; other site
393130000680	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
393130000681	motif 1; other site
393130000682	active site
393130000683	motif 2; other site
393130000684	motif 3; other site
393130000685	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
393130000686	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
393130000687	UvrB/uvrC motif; Region: UVR; pfam02151
393130000688	Arginine kinase [Amino acid transport and metabolism]; Region: COG3869
393130000689	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
393130000690	ADP binding site [chemical binding]; other site
393130000691	phosphagen binding site; other site
393130000692	substrate specificity loop; other site
393130000693	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
393130000694	Clp amino terminal domain; Region: Clp_N; pfam02861
393130000695	Clp amino terminal domain; Region: Clp_N; pfam02861
393130000696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130000697	Walker A motif; other site
393130000698	ATP binding site [chemical binding]; other site
393130000699	Walker B motif; other site
393130000700	arginine finger; other site
393130000701	UvrB/uvrC motif; Region: UVR; pfam02151
393130000702	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130000703	Walker A motif; other site
393130000704	ATP binding site [chemical binding]; other site
393130000705	Walker B motif; other site
393130000706	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393130000707	DNA repair protein RadA; Provisional; Region: PRK11823
393130000708	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
393130000709	Walker A motif/ATP binding site; other site
393130000710	ATP binding site [chemical binding]; other site
393130000711	Walker B motif; other site
393130000712	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
393130000713	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
393130000714	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
393130000715	putative active site [active]
393130000716	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
393130000717	substrate binding site; other site
393130000718	dimer interface; other site
393130000719	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
393130000720	homotrimer interaction site [polypeptide binding]; other site
393130000721	zinc binding site [ion binding]; other site
393130000722	CDP-binding sites; other site
393130000723	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
393130000724	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
393130000725	HIGH motif; other site
393130000726	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
393130000727	active site
393130000728	KMSKS motif; other site
393130000729	serine O-acetyltransferase; Region: cysE; TIGR01172
393130000730	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
393130000731	trimer interface [polypeptide binding]; other site
393130000732	active site
393130000733	substrate binding site [chemical binding]; other site
393130000734	CoA binding site [chemical binding]; other site
393130000735	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
393130000736	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
393130000737	active site
393130000738	HIGH motif; other site
393130000739	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
393130000740	KMSKS motif; other site
393130000741	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
393130000742	tRNA binding surface [nucleotide binding]; other site
393130000743	anticodon binding site; other site
393130000744	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
393130000745	active site
393130000746	metal binding site [ion binding]; metal-binding site
393130000747	dimerization interface [polypeptide binding]; other site
393130000748	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
393130000749	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
393130000750	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
393130000751	Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688
393130000752	RNA polymerase factor sigma-70; Validated; Region: PRK08295
393130000753	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393130000754	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
393130000755	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
393130000756	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
393130000757	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
393130000758	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
393130000759	putative homodimer interface [polypeptide binding]; other site
393130000760	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
393130000761	heterodimer interface [polypeptide binding]; other site
393130000762	homodimer interface [polypeptide binding]; other site
393130000763	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
393130000764	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
393130000765	23S rRNA interface [nucleotide binding]; other site
393130000766	L7/L12 interface [polypeptide binding]; other site
393130000767	putative thiostrepton binding site; other site
393130000768	L25 interface [polypeptide binding]; other site
393130000769	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
393130000770	mRNA/rRNA interface [nucleotide binding]; other site
393130000771	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
393130000772	23S rRNA interface [nucleotide binding]; other site
393130000773	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
393130000774	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
393130000775	core dimer interface [polypeptide binding]; other site
393130000776	peripheral dimer interface [polypeptide binding]; other site
393130000777	L10 interface [polypeptide binding]; other site
393130000778	L11 interface [polypeptide binding]; other site
393130000779	putative EF-Tu interaction site [polypeptide binding]; other site
393130000780	putative EF-G interaction site [polypeptide binding]; other site
393130000781	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
393130000782	Penicillinase repressor; Region: Pencillinase_R; pfam03965
393130000783	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
393130000784	Protein of unknown function (DUF1266); Region: DUF1266; pfam06889
393130000785	Protein of unknown function (DUF1307); Region: DUF1307; pfam06998
393130000786	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393130000787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130000788	S-adenosylmethionine binding site [chemical binding]; other site
393130000789	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
393130000790	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130000791	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130000792	DNA binding site [nucleotide binding]
393130000793	domain linker motif; other site
393130000794	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
393130000795	putative dimerization interface [polypeptide binding]; other site
393130000796	putative ligand binding site [chemical binding]; other site
393130000797	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
393130000798	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130000799	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393130000800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000801	dimer interface [polypeptide binding]; other site
393130000802	conserved gate region; other site
393130000803	putative PBP binding loops; other site
393130000804	ABC-ATPase subunit interface; other site
393130000805	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130000806	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000807	dimer interface [polypeptide binding]; other site
393130000808	conserved gate region; other site
393130000809	putative PBP binding loops; other site
393130000810	ABC-ATPase subunit interface; other site
393130000811	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393130000812	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393130000813	Ca binding site [ion binding]; other site
393130000814	active site
393130000815	catalytic site [active]
393130000816	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
393130000817	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
393130000818	active site
393130000819	homodimer interface [polypeptide binding]; other site
393130000820	catalytic site [active]
393130000821	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
393130000822	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393130000823	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393130000824	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
393130000825	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
393130000826	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
393130000827	RPB10 interaction site [polypeptide binding]; other site
393130000828	RPB1 interaction site [polypeptide binding]; other site
393130000829	RPB11 interaction site [polypeptide binding]; other site
393130000830	RPB3 interaction site [polypeptide binding]; other site
393130000831	RPB12 interaction site [polypeptide binding]; other site
393130000832	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
393130000833	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
393130000834	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
393130000835	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
393130000836	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
393130000837	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
393130000838	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
393130000839	G-loop; other site
393130000840	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
393130000841	DNA binding site [nucleotide binding]
393130000842	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
393130000843	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
393130000844	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000845	active site
393130000846	motif I; other site
393130000847	motif II; other site
393130000848	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130000849	beta-galactosidase; Region: BGL; TIGR03356
393130000850	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130000851	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000852	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000853	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000854	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000855	LRR adjacent; Region: LRR_adjacent; pfam08191
393130000856	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130000857	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130000858	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130000859	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130000860	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000861	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000862	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000863	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000864	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000865	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000866	LRR adjacent; Region: LRR_adjacent; pfam08191
393130000867	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130000868	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130000869	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130000870	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000871	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000872	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000873	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000874	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130000875	LRR adjacent; Region: LRR_adjacent; pfam08191
393130000876	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130000877	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130000878	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588
393130000879	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
393130000880	metal binding site [ion binding]; metal-binding site
393130000881	dimer interface [polypeptide binding]; other site
393130000882	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130000883	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130000884	putative Zn2+ binding site [ion binding]; other site
393130000885	putative DNA binding site [nucleotide binding]; other site
393130000886	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393130000887	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130000888	Zn binding site [ion binding]; other site
393130000889	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393130000890	Zn binding site [ion binding]; other site
393130000891	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130000892	catalytic core [active]
393130000893	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
393130000894	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393130000895	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393130000896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000897	dimer interface [polypeptide binding]; other site
393130000898	conserved gate region; other site
393130000899	ABC-ATPase subunit interface; other site
393130000900	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393130000901	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130000902	Leucine-rich repeats; other site
393130000903	Substrate binding site [chemical binding]; other site
393130000904	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
393130000905	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130000906	beta-galactosidase; Region: BGL; TIGR03356
393130000907	sugar phosphate phosphatase; Provisional; Region: PRK10513
393130000908	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000909	active site
393130000910	motif I; other site
393130000911	motif II; other site
393130000912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000913	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130000914	Coenzyme A binding pocket [chemical binding]; other site
393130000915	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000916	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
393130000917	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
393130000918	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393130000919	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000920	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
393130000921	active site
393130000922	motif I; other site
393130000923	motif II; other site
393130000924	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130000925	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130000926	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130000927	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393130000928	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
393130000929	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
393130000930	Walker A/P-loop; other site
393130000931	ATP binding site [chemical binding]; other site
393130000932	Q-loop/lid; other site
393130000933	ABC transporter signature motif; other site
393130000934	Walker B; other site
393130000935	D-loop; other site
393130000936	H-loop/switch region; other site
393130000937	TOBE domain; Region: TOBE; pfam03459
393130000938	ATP cone domain; Region: ATP-cone; pfam03477
393130000939	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
393130000940	Class III ribonucleotide reductase; Region: RNR_III; cd01675
393130000941	effector binding site; other site
393130000942	active site
393130000943	Zn binding site [ion binding]; other site
393130000944	glycine loop; other site
393130000945	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
393130000946	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
393130000947	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130000948	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130000949	ligand binding site [chemical binding]; other site
393130000950	flexible hinge region; other site
393130000951	Predicted amidohydrolase [General function prediction only]; Region: COG0388
393130000952	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
393130000953	putative active site [active]
393130000954	catalytic triad [active]
393130000955	putative dimer interface [polypeptide binding]; other site
393130000956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130000957	dimer interface [polypeptide binding]; other site
393130000958	conserved gate region; other site
393130000959	ABC-ATPase subunit interface; other site
393130000960	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
393130000961	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
393130000962	Walker A/P-loop; other site
393130000963	ATP binding site [chemical binding]; other site
393130000964	Q-loop/lid; other site
393130000965	ABC transporter signature motif; other site
393130000966	Walker B; other site
393130000967	D-loop; other site
393130000968	H-loop/switch region; other site
393130000969	NIL domain; Region: NIL; pfam09383
393130000970	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
393130000971	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
393130000972	transaminase; Reviewed; Region: PRK08068
393130000973	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130000974	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130000975	homodimer interface [polypeptide binding]; other site
393130000976	catalytic residue [active]
393130000977	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130000978	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130000979	active site
393130000980	phosphorylation site [posttranslational modification]
393130000981	intermolecular recognition site; other site
393130000982	dimerization interface [polypeptide binding]; other site
393130000983	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130000984	DNA binding site [nucleotide binding]
393130000985	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
393130000986	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130000987	dimerization interface [polypeptide binding]; other site
393130000988	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393130000989	putative active site [active]
393130000990	heme pocket [chemical binding]; other site
393130000991	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130000992	dimer interface [polypeptide binding]; other site
393130000993	phosphorylation site [posttranslational modification]
393130000994	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130000995	ATP binding site [chemical binding]; other site
393130000996	Mg2+ binding site [ion binding]; other site
393130000997	G-X-G motif; other site
393130000998	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
393130000999	YycH protein; Region: YycH; pfam07435
393130001000	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853
393130001001	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
393130001002	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
393130001003	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
393130001004	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
393130001005	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
393130001006	protein binding site [polypeptide binding]; other site
393130001007	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
393130001008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130001009	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130001010	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393130001011	dimerization interface [polypeptide binding]; other site
393130001012	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393130001013	dimer interface [polypeptide binding]; other site
393130001014	FMN binding site [chemical binding]; other site
393130001015	NADPH bind site [chemical binding]; other site
393130001016	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130001017	HTH domain; Region: HTH_11; pfam08279
393130001018	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130001019	PRD domain; Region: PRD; pfam00874
393130001020	PRD domain; Region: PRD; pfam00874
393130001021	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130001022	active site
393130001023	P-loop; other site
393130001024	phosphorylation site [posttranslational modification]
393130001025	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001026	active site
393130001027	phosphorylation site [posttranslational modification]
393130001028	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130001029	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130001030	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130001031	active site
393130001032	P-loop; other site
393130001033	phosphorylation site [posttranslational modification]
393130001034	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130001035	beta-galactosidase; Region: BGL; TIGR03356
393130001036	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130001037	methionine cluster; other site
393130001038	active site
393130001039	phosphorylation site [posttranslational modification]
393130001040	metal binding site [ion binding]; metal-binding site
393130001041	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
393130001042	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
393130001043	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
393130001044	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
393130001045	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130001046	catalytic residue [active]
393130001047	Protein of unknown function (DUF1433); Region: DUF1433; pfam07252
393130001048	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
393130001049	putative active site [active]
393130001050	YdjC motif; other site
393130001051	Mg binding site [ion binding]; other site
393130001052	putative homodimer interface [polypeptide binding]; other site
393130001053	Putative transcription activator [Transcription]; Region: TenA; COG0819
393130001054	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
393130001055	substrate binding site [chemical binding]; other site
393130001056	multimerization interface [polypeptide binding]; other site
393130001057	ATP binding site [chemical binding]; other site
393130001058	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
393130001059	dimer interface [polypeptide binding]; other site
393130001060	substrate binding site [chemical binding]; other site
393130001061	ATP binding site [chemical binding]; other site
393130001062	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
393130001063	thiamine phosphate binding site [chemical binding]; other site
393130001064	active site
393130001065	pyrophosphate binding site [ion binding]; other site
393130001066	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130001067	beta-galactosidase; Region: BGL; TIGR03356
393130001068	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130001069	Protein of unknown function (DUF2910); Region: DUF2910; pfam11139
393130001070	Protein of unknown function (DUF1696); Region: DUF1696; pfam08000
393130001071	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
393130001072	putative catalytic site [active]
393130001073	putative metal binding site [ion binding]; other site
393130001074	putative phosphate binding site [ion binding]; other site
393130001075	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130001076	non-specific DNA binding site [nucleotide binding]; other site
393130001077	salt bridge; other site
393130001078	sequence-specific DNA binding site [nucleotide binding]; other site
393130001079	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393130001080	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130001081	non-specific DNA binding site [nucleotide binding]; other site
393130001082	salt bridge; other site
393130001083	sequence-specific DNA binding site [nucleotide binding]; other site
393130001084	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393130001085	Leucine rich repeat; Region: LRR_8; pfam13855
393130001086	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001087	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001088	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001089	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001090	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001091	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001092	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001093	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001094	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001095	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001096	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001097	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001098	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001099	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001100	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130001101	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001102	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001103	LRR adjacent; Region: LRR_adjacent; pfam08191
393130001104	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001105	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001106	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
393130001107	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
393130001108	catalytic residues [active]
393130001109	catalytic nucleophile [active]
393130001110	Presynaptic Site I dimer interface [polypeptide binding]; other site
393130001111	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
393130001112	Synaptic Flat tetramer interface [polypeptide binding]; other site
393130001113	Synaptic Site I dimer interface [polypeptide binding]; other site
393130001114	DNA binding site [nucleotide binding]
393130001115	Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796
393130001116	Cupin domain; Region: Cupin_2; pfam07883
393130001117	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001118	catalytic core [active]
393130001119	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
393130001120	active site
393130001121	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
393130001122	AAA domain; Region: AAA_18; pfam13238
393130001123	AAA domain; Region: AAA_17; pfam13207
393130001124	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393130001125	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393130001126	TPP-binding site [chemical binding]; other site
393130001127	dimer interface [polypeptide binding]; other site
393130001128	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130001129	PYR/PP interface [polypeptide binding]; other site
393130001130	dimer interface [polypeptide binding]; other site
393130001131	TPP binding site [chemical binding]; other site
393130001132	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130001133	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
393130001134	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
393130001135	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
393130001136	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
393130001137	putative active site cavity [active]
393130001138	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130001139	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
393130001140	active site
393130001141	motif I; other site
393130001142	motif II; other site
393130001143	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
393130001144	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130001145	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130001146	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130001147	active site
393130001148	P-loop; other site
393130001149	phosphorylation site [posttranslational modification]
393130001150	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130001151	active site
393130001152	methionine cluster; other site
393130001153	phosphorylation site [posttranslational modification]
393130001154	metal binding site [ion binding]; metal-binding site
393130001155	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130001156	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130001157	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130001158	putative active site [active]
393130001159	putative transposase OrfB; Reviewed; Region: PHA02517
393130001160	HTH-like domain; Region: HTH_21; pfam13276
393130001161	Integrase core domain; Region: rve; pfam00665
393130001162	Integrase core domain; Region: rve_3; cl15866
393130001163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
393130001164	Leucine rich repeat; Region: LRR_8; pfam13855
393130001165	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130001166	Leucine rich repeat; Region: LRR_8; pfam13855
393130001167	LRR adjacent; Region: LRR_adjacent; pfam08191
393130001168	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001169	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001170	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001171	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001172	LRR adjacent; Region: LRR_adjacent; pfam08191
393130001173	Flavodoxin domain; Region: Flavodoxin_5; pfam12724
393130001174	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
393130001175	LXG domain of WXG superfamily; Region: LXG; pfam04740
393130001176	Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221
393130001177	Enterocin A Immunity; Region: EntA_Immun; pfam08951
393130001178	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393130001179	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393130001180	TPP-binding site [chemical binding]; other site
393130001181	dimer interface [polypeptide binding]; other site
393130001182	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130001183	PYR/PP interface [polypeptide binding]; other site
393130001184	dimer interface [polypeptide binding]; other site
393130001185	TPP binding site [chemical binding]; other site
393130001186	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130001187	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
393130001188	active site
393130001189	intersubunit interactions; other site
393130001190	catalytic residue [active]
393130001191	short chain dehydrogenase; Provisional; Region: PRK06841
393130001192	classical (c) SDRs; Region: SDR_c; cd05233
393130001193	NAD(P) binding site [chemical binding]; other site
393130001194	active site
393130001195	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393130001196	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
393130001197	substrate binding site [chemical binding]; other site
393130001198	dimer interface [polypeptide binding]; other site
393130001199	catalytic triad [active]
393130001200	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393130001201	DAK2 domain; Region: Dak2; cl03685
393130001202	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
393130001203	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393130001204	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
393130001205	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130001206	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130001207	putative DNA binding site [nucleotide binding]; other site
393130001208	putative Zn2+ binding site [ion binding]; other site
393130001209	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130001210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130001211	Coenzyme A binding pocket [chemical binding]; other site
393130001212	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
393130001213	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
393130001214	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
393130001215	acyl-activating enzyme (AAE) consensus motif; other site
393130001216	acyl-activating enzyme (AAE) consensus motif; other site
393130001217	AMP binding site [chemical binding]; other site
393130001218	active site
393130001219	CoA binding site [chemical binding]; other site
393130001220	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
393130001221	L-aspartate oxidase; Provisional; Region: PRK06175
393130001222	putative oxidoreductase; Provisional; Region: PRK10206
393130001223	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130001224	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393130001225	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001226	active site
393130001227	phosphorylation site [posttranslational modification]
393130001228	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
393130001229	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130001230	active site
393130001231	P-loop; other site
393130001232	phosphorylation site [posttranslational modification]
393130001233	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130001234	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393130001235	intersubunit interface [polypeptide binding]; other site
393130001236	active site
393130001237	zinc binding site [ion binding]; other site
393130001238	Na+ binding site [ion binding]; other site
393130001239	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130001240	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
393130001241	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130001242	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
393130001243	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
393130001244	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
393130001245	conserved cys residue [active]
393130001246	Predicted transcriptional regulator [Transcription]; Region: COG2378
393130001247	HTH domain; Region: HTH_11; pfam08279
393130001248	WYL domain; Region: WYL; pfam13280
393130001249	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
393130001250	Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822
393130001251	Imelysin; Region: Peptidase_M75; pfam09375
393130001252	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
393130001253	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693
393130001254	nudix motif; other site
393130001255	hypothetical protein; Provisional; Region: PRK12378
393130001256	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
393130001257	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
393130001258	PhnA protein; Region: PhnA; pfam03831
393130001259	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130001260	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130001261	DNA-binding site [nucleotide binding]; DNA binding site
393130001262	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393130001263	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130001264	beta-galactosidase; Region: BGL; TIGR03356
393130001265	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130001266	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
393130001267	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130001268	active site
393130001269	P-loop; other site
393130001270	phosphorylation site [posttranslational modification]
393130001271	Predicted transcriptional regulator [Transcription]; Region: COG2378
393130001272	HTH domain; Region: HTH_11; pfam08279
393130001273	WYL domain; Region: WYL; pfam13280
393130001274	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
393130001275	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130001276	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393130001277	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130001278	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
393130001279	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
393130001280	tetrameric interface [polypeptide binding]; other site
393130001281	NAD binding site [chemical binding]; other site
393130001282	catalytic residues [active]
393130001283	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
393130001284	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
393130001285	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
393130001286	substrate binding site [chemical binding]; other site
393130001287	ATP binding site [chemical binding]; other site
393130001288	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
393130001289	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393130001290	PYR/PP interface [polypeptide binding]; other site
393130001291	dimer interface [polypeptide binding]; other site
393130001292	TPP binding site [chemical binding]; other site
393130001293	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393130001294	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
393130001295	TPP-binding site; other site
393130001296	Uncharacterized conserved protein [Function unknown]; Region: COG5646
393130001297	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
393130001298	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
393130001299	ligand binding site [chemical binding]; other site
393130001300	active site
393130001301	UGI interface [polypeptide binding]; other site
393130001302	catalytic site [active]
393130001303	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
393130001304	hypothetical protein; Provisional; Region: PRK13665
393130001305	Bacterial SH3 domain; Region: SH3_3; cl17532
393130001306	NlpC/P60 family; Region: NLPC_P60; pfam00877
393130001307	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130001308	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130001309	Coenzyme A binding pocket [chemical binding]; other site
393130001310	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
393130001311	pyrroline-5-carboxylate reductase; Region: PLN02688
393130001312	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899
393130001313	putative hydrophobic ligand binding site [chemical binding]; other site
393130001314	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001315	active site
393130001316	phosphorylation site [posttranslational modification]
393130001317	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130001318	active site
393130001319	P-loop; other site
393130001320	phosphorylation site [posttranslational modification]
393130001321	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130001322	alpha-mannosidase; Provisional; Region: PRK09819
393130001323	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393130001324	active site
393130001325	metal binding site [ion binding]; metal-binding site
393130001326	catalytic site [active]
393130001327	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393130001328	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130001329	HTH domain; Region: HTH_11; pfam08279
393130001330	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130001331	PRD domain; Region: PRD; pfam00874
393130001332	PRD domain; Region: PRD; pfam00874
393130001333	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130001334	active site
393130001335	P-loop; other site
393130001336	phosphorylation site [posttranslational modification]
393130001337	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001338	active site
393130001339	phosphorylation site [posttranslational modification]
393130001340	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
393130001341	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
393130001342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130001343	putative metal binding site [ion binding]; other site
393130001344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
393130001345	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
393130001346	trimer interface [polypeptide binding]; other site
393130001347	phosphoenolpyruvate synthase; Validated; Region: PRK06241
393130001348	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
393130001349	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393130001350	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
393130001351	ZIP Zinc transporter; Region: Zip; pfam02535
393130001352	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
393130001353	Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954
393130001354	NodB motif; other site
393130001355	active site
393130001356	catalytic site [active]
393130001357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130001358	non-specific DNA binding site [nucleotide binding]; other site
393130001359	salt bridge; other site
393130001360	sequence-specific DNA binding site [nucleotide binding]; other site
393130001361	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
393130001362	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130001363	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
393130001364	active site
393130001365	motif I; other site
393130001366	motif II; other site
393130001367	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130001368	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393130001369	lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416
393130001370	Predicted transcriptional regulators [Transcription]; Region: COG1695
393130001371	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
393130001372	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393130001373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393130001374	DNA binding residues [nucleotide binding]
393130001375	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
393130001376	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130001377	HTH domain; Region: HTH_11; pfam08279
393130001378	PRD domain; Region: PRD; pfam00874
393130001379	PRD domain; Region: PRD; pfam00874
393130001380	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130001381	active site
393130001382	P-loop; other site
393130001383	phosphorylation site [posttranslational modification]
393130001384	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001385	active site
393130001386	phosphorylation site [posttranslational modification]
393130001387	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001388	active site
393130001389	phosphorylation site [posttranslational modification]
393130001390	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130001391	active site
393130001392	P-loop; other site
393130001393	phosphorylation site [posttranslational modification]
393130001394	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130001395	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393130001396	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393130001397	active site
393130001398	metal binding site [ion binding]; metal-binding site
393130001399	catalytic site [active]
393130001400	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
393130001401	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130001402	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130001403	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393130001404	dimerization interface [polypeptide binding]; other site
393130001405	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
393130001406	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
393130001407	active site
393130001408	substrate binding site [chemical binding]; other site
393130001409	trimer interface [polypeptide binding]; other site
393130001410	CoA binding site [chemical binding]; other site
393130001411	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
393130001412	classical (c) SDRs; Region: SDR_c; cd05233
393130001413	NAD(P) binding site [chemical binding]; other site
393130001414	active site
393130001415	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130001416	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001417	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130001418	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001419	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001420	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001421	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001422	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001423	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001424	LRR adjacent; Region: LRR_adjacent; pfam08191
393130001425	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001426	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001427	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001428	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130001429	Leucine rich repeat; Region: LRR_8; pfam13855
393130001430	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130001431	Leucine rich repeat; Region: LRR_8; pfam13855
393130001432	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001433	LRR adjacent; Region: LRR_adjacent; pfam08191
393130001434	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001435	SH3-like domain; Region: SH3_8; pfam13457
393130001436	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130001437	Predicted transcriptional regulator [Transcription]; Region: COG1959
393130001438	Transcriptional regulator; Region: Rrf2; pfam02082
393130001439	Transcriptional regulator; Region: Rrf2; cl17282
393130001440	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393130001441	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
393130001442	NAD(P) binding site [chemical binding]; other site
393130001443	active site
393130001444	Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908
393130001445	Protein of unknown function (DUF2004); Region: DUF2004; pfam09406
393130001446	NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223
393130001447	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
393130001448	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393130001449	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393130001450	Transcriptional regulator [Transcription]; Region: LytR; COG1316
393130001451	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
393130001452	Signal peptide peptidase; Region: Peptidase_A22B; cl01342
393130001453	Predicted membrane protein [Function unknown]; Region: COG3619
393130001454	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
393130001455	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
393130001456	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
393130001457	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
393130001458	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
393130001459	Protein of unknown function DUF58; Region: DUF58; pfam01882
393130001460	MoxR-like ATPases [General function prediction only]; Region: COG0714
393130001461	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130001462	Walker A motif; other site
393130001463	ATP binding site [chemical binding]; other site
393130001464	Walker B motif; other site
393130001465	arginine finger; other site
393130001466	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
393130001467	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
393130001468	Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457
393130001469	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
393130001470	Na binding site [ion binding]; other site
393130001471	Uncharacterized conserved protein [Function unknown]; Region: COG3535
393130001472	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
393130001473	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130001474	nucleotide binding site [chemical binding]; other site
393130001475	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
393130001476	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130001477	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
393130001478	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
393130001479	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001480	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001481	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001482	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
393130001483	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001484	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001485	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001486	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001487	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001488	Leucine rich repeat; Region: LRR_8; pfam13855
393130001489	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001490	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
393130001491	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001492	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001493	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
393130001494	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001495	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001496	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001497	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001498	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001499	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
393130001500	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
393130001501	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
393130001502	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
393130001503	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130001504	Zn2+ binding site [ion binding]; other site
393130001505	Mg2+ binding site [ion binding]; other site
393130001506	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393130001507	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393130001508	Protein of unknown function (DUF3139); Region: DUF3139; pfam11337
393130001509	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
393130001510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130001511	Myosin-crossreactive antigen [Function unknown]; Region: COG4716
393130001512	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
393130001513	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393130001514	FeS/SAM binding site; other site
393130001515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
393130001516	heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316
393130001517	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
393130001518	putative FMN binding site [chemical binding]; other site
393130001519	Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333
393130001520	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
393130001521	nudix motif; other site
393130001522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130001523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130001524	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393130001525	putative dimerization interface [polypeptide binding]; other site
393130001526	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
393130001527	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
393130001528	active site
393130001529	FMN binding site [chemical binding]; other site
393130001530	substrate binding site [chemical binding]; other site
393130001531	putative catalytic residue [active]
393130001532	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
393130001533	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130001534	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130001535	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
393130001536	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393130001537	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393130001538	shikimate binding site; other site
393130001539	NAD(P) binding site [chemical binding]; other site
393130001540	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
393130001541	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
393130001542	active site
393130001543	catalytic residue [active]
393130001544	dimer interface [polypeptide binding]; other site
393130001545	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130001546	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130001547	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
393130001548	dimerization interface [polypeptide binding]; other site
393130001549	substrate binding pocket [chemical binding]; other site
393130001550	Predicted acyl esterases [General function prediction only]; Region: COG2936
393130001551	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
393130001552	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
393130001553	active site
393130001554	catalytic triad [active]
393130001555	oxyanion hole [active]
393130001556	EamA-like transporter family; Region: EamA; pfam00892
393130001557	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
393130001558	EamA-like transporter family; Region: EamA; pfam00892
393130001559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224
393130001560	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393130001561	active site
393130001562	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393130001563	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130001564	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130001565	substrate binding site [chemical binding]; other site
393130001566	hexamer interface [polypeptide binding]; other site
393130001567	metal binding site [ion binding]; metal-binding site
393130001568	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
393130001569	catalytic residue [active]
393130001570	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130001571	PRD domain; Region: PRD; pfam00874
393130001572	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130001573	active site
393130001574	P-loop; other site
393130001575	phosphorylation site [posttranslational modification]
393130001576	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001577	active site
393130001578	phosphorylation site [posttranslational modification]
393130001579	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
393130001580	putative active site [active]
393130001581	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001582	active site
393130001583	phosphorylation site [posttranslational modification]
393130001584	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130001585	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130001586	substrate binding site [chemical binding]; other site
393130001587	hexamer interface [polypeptide binding]; other site
393130001588	metal binding site [ion binding]; metal-binding site
393130001589	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393130001590	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
393130001591	putative NAD(P) binding site [chemical binding]; other site
393130001592	catalytic Zn binding site [ion binding]; other site
393130001593	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393130001594	active site
393130001595	P-loop; other site
393130001596	phosphorylation site [posttranslational modification]
393130001597	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393130001598	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393130001599	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
393130001600	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
393130001601	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130001602	active site
393130001603	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
393130001604	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
393130001605	catalytic triad [active]
393130001606	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
393130001607	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130001608	MarR family; Region: MarR_2; pfam12802
393130001609	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001610	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130001611	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393130001612	Ligand Binding Site [chemical binding]; other site
393130001613	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
393130001614	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
393130001615	putative active site [active]
393130001616	putative metal binding site [ion binding]; other site
393130001617	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001618	catalytic core [active]
393130001619	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001620	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
393130001621	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09754
393130001622	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl09909
393130001623	CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875
393130001624	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803
393130001625	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
393130001626	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
393130001627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393130001628	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
393130001629	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
393130001630	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
393130001631	Predicted membrane protein [Function unknown]; Region: COG3759
393130001632	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130001633	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130001634	putative substrate translocation pore; other site
393130001635	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393130001636	non-specific DNA interactions [nucleotide binding]; other site
393130001637	DNA binding site [nucleotide binding]
393130001638	sequence specific DNA binding site [nucleotide binding]; other site
393130001639	putative cAMP binding site [chemical binding]; other site
393130001640	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130001641	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
393130001642	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
393130001643	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
393130001644	NAD binding site [chemical binding]; other site
393130001645	sugar binding site [chemical binding]; other site
393130001646	divalent metal binding site [ion binding]; other site
393130001647	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130001648	dimer interface [polypeptide binding]; other site
393130001649	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130001650	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130001651	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130001652	putative active site [active]
393130001653	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
393130001654	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
393130001655	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393130001656	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
393130001657	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393130001658	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393130001659	Protein of unknown function (DUF1214); Region: DUF1214; cl08447
393130001660	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
393130001661	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393130001662	DNA binding residues [nucleotide binding]
393130001663	dimer interface [polypeptide binding]; other site
393130001664	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
393130001665	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
393130001666	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
393130001667	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
393130001668	DXD motif; other site
393130001669	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
393130001670	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
393130001671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393130001672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130001673	S-adenosylmethionine binding site [chemical binding]; other site
393130001674	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
393130001675	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
393130001676	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130001677	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130001678	DNA binding site [nucleotide binding]
393130001679	domain linker motif; other site
393130001680	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
393130001681	putative dimerization interface [polypeptide binding]; other site
393130001682	putative ligand binding site [chemical binding]; other site
393130001683	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
393130001684	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
393130001685	NAD binding site [chemical binding]; other site
393130001686	sugar binding site [chemical binding]; other site
393130001687	divalent metal binding site [ion binding]; other site
393130001688	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130001689	dimer interface [polypeptide binding]; other site
393130001690	allantoate amidohydrolase; Reviewed; Region: PRK09290
393130001691	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
393130001692	active site
393130001693	metal binding site [ion binding]; metal-binding site
393130001694	dimer interface [polypeptide binding]; other site
393130001695	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393130001696	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019
393130001697	metal binding site [ion binding]; metal-binding site
393130001698	putative dimer interface [polypeptide binding]; other site
393130001699	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
393130001700	Beta-lactamase; Region: Beta-lactamase; pfam00144
393130001701	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
393130001702	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
393130001703	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
393130001704	intersubunit interface [polypeptide binding]; other site
393130001705	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829
393130001706	Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732
393130001707	Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612
393130001708	Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663
393130001709	PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608
393130001710	Glucitol operon activator protein (GutM); Region: GutM; cl01890
393130001711	Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091
393130001712	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130001713	SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616
393130001714	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393130001715	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393130001716	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130001717	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001718	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001719	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001720	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130001721	WxL domain surface cell wall-binding; Region: WxL; pfam13731
393130001722	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
393130001723	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
393130001724	FOG: CBS domain [General function prediction only]; Region: COG0517
393130001725	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
393130001726	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
393130001727	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
393130001728	dimer interface [polypeptide binding]; other site
393130001729	active site
393130001730	metal binding site [ion binding]; metal-binding site
393130001731	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
393130001732	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130001733	putative substrate translocation pore; other site
393130001734	POT family; Region: PTR2; pfam00854
393130001735	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001736	catalytic core [active]
393130001737	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001738	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130001739	catalytic core [active]
393130001740	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
393130001741	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
393130001742	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393130001743	Cl binding site [ion binding]; other site
393130001744	oligomer interface [polypeptide binding]; other site
393130001745	glutamate dehydrogenase; Provisional; Region: PRK09414
393130001746	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
393130001747	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
393130001748	NAD(P) binding site [chemical binding]; other site
393130001749	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
393130001750	metal binding site [ion binding]; metal-binding site
393130001751	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
393130001752	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
393130001753	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
393130001754	substrate binding site [chemical binding]; other site
393130001755	glutamase interaction surface [polypeptide binding]; other site
393130001756	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
393130001757	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
393130001758	catalytic residues [active]
393130001759	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
393130001760	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
393130001761	putative active site [active]
393130001762	oxyanion strand; other site
393130001763	catalytic triad [active]
393130001764	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
393130001765	putative active site pocket [active]
393130001766	4-fold oligomerization interface [polypeptide binding]; other site
393130001767	metal binding residues [ion binding]; metal-binding site
393130001768	3-fold/trimer interface [polypeptide binding]; other site
393130001769	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
393130001770	histidinol dehydrogenase; Region: hisD; TIGR00069
393130001771	NAD binding site [chemical binding]; other site
393130001772	dimerization interface [polypeptide binding]; other site
393130001773	product binding site; other site
393130001774	substrate binding site [chemical binding]; other site
393130001775	zinc binding site [ion binding]; other site
393130001776	catalytic residues [active]
393130001777	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
393130001778	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
393130001779	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
393130001780	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
393130001781	dimer interface [polypeptide binding]; other site
393130001782	motif 1; other site
393130001783	active site
393130001784	motif 2; other site
393130001785	motif 3; other site
393130001786	histidinol-phosphatase; Reviewed; Region: PRK08123
393130001787	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
393130001788	active site
393130001789	dimer interface [polypeptide binding]; other site
393130001790	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393130001791	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393130001792	DNA binding site [nucleotide binding]
393130001793	active site
393130001794	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
393130001795	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393130001796	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130001797	beta-galactosidase; Region: BGL; TIGR03356
393130001798	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130001799	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130001800	DNA-binding site [nucleotide binding]; DNA binding site
393130001801	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393130001802	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001803	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130001804	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
393130001805	Uncharacterized conserved protein [Function unknown]; Region: COG2966
393130001806	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
393130001807	Protein of unknown function (DUF3815); Region: DUF3815; cl01118
393130001808	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
393130001809	Predicted esterase [General function prediction only]; Region: COG0400
393130001810	putative hydrolase; Provisional; Region: PRK11460
393130001811	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
393130001812	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
393130001813	putative RNA binding site [nucleotide binding]; other site
393130001814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130001815	S-adenosylmethionine binding site [chemical binding]; other site
393130001816	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
393130001817	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130001818	Bacterial SH3 domain; Region: SH3_3; pfam08239
393130001819	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130001820	NlpC/P60 family; Region: NLPC_P60; pfam00877
393130001821	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
393130001822	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393130001823	ATP binding site [chemical binding]; other site
393130001824	putative Mg++ binding site [ion binding]; other site
393130001825	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
393130001826	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
393130001827	nucleotide binding region [chemical binding]; other site
393130001828	ATP-binding site [chemical binding]; other site
393130001829	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393130001830	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393130001831	WxL domain surface cell wall-binding; Region: WxL; pfam13731
393130001832	Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030
393130001833	Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797
393130001834	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
393130001835	DNA photolyase; Region: DNA_photolyase; pfam00875
393130001836	Predicted membrane protein [Function unknown]; Region: COG4852
393130001837	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
393130001838	DAK2 domain; Region: Dak2; pfam02734
393130001839	EDD domain protein, DegV family; Region: DegV; TIGR00762
393130001840	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393130001841	Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752
393130001842	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
393130001843	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
393130001844	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
393130001845	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
393130001846	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393130001847	homodimer interface [polypeptide binding]; other site
393130001848	substrate-cofactor binding pocket; other site
393130001849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130001850	catalytic residue [active]
393130001851	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
393130001852	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130001853	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393130001854	ligand binding site [chemical binding]; other site
393130001855	flexible hinge region; other site
393130001856	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130001857	BioY family; Region: BioY; pfam02632
393130001858	Predicted transcriptional regulators [Transcription]; Region: COG1695
393130001859	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
393130001860	Predicted membrane protein [Function unknown]; Region: COG4709
393130001861	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393130001862	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393130001863	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393130001864	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393130001865	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393130001866	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130001867	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393130001868	Coenzyme A binding pocket [chemical binding]; other site
393130001869	Tic20-like protein; Region: Tic20; pfam09685
393130001870	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
393130001871	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393130001872	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393130001873	MarR family; Region: MarR_2; pfam12802
393130001874	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130001875	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130001876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130001877	Walker A/P-loop; other site
393130001878	ATP binding site [chemical binding]; other site
393130001879	Q-loop/lid; other site
393130001880	ABC transporter signature motif; other site
393130001881	Walker B; other site
393130001882	D-loop; other site
393130001883	H-loop/switch region; other site
393130001884	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130001885	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130001886	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
393130001887	Walker A/P-loop; other site
393130001888	ATP binding site [chemical binding]; other site
393130001889	Q-loop/lid; other site
393130001890	ABC transporter signature motif; other site
393130001891	Walker B; other site
393130001892	D-loop; other site
393130001893	H-loop/switch region; other site
393130001894	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
393130001895	active site residue [active]
393130001896	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001897	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130001898	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393130001899	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393130001900	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393130001901	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130001902	putative DNA binding site [nucleotide binding]; other site
393130001903	putative Zn2+ binding site [ion binding]; other site
393130001904	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
393130001905	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
393130001906	putative NAD(P) binding site [chemical binding]; other site
393130001907	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393130001908	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393130001909	Coenzyme A binding pocket [chemical binding]; other site
393130001910	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
393130001911	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
393130001912	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
393130001913	putative active site [active]
393130001914	catalytic site [active]
393130001915	putative metal binding site [ion binding]; other site
393130001916	Catalytic domain of Protein Kinases; Region: PKc; cd00180
393130001917	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
393130001918	active site
393130001919	ATP binding site [chemical binding]; other site
393130001920	substrate binding site [chemical binding]; other site
393130001921	activation loop (A-loop); other site
393130001922	Protein of unknown function (DUF1398); Region: DUF1398; cl11576
393130001923	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
393130001924	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393130001925	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130001926	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130001927	Coenzyme A binding pocket [chemical binding]; other site
393130001928	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
393130001929	active site
393130001930	catalytic triad [active]
393130001931	oxyanion hole [active]
393130001932	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393130001933	domain interaction interfaces [polypeptide binding]; other site
393130001934	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393130001935	domain interaction interfaces [polypeptide binding]; other site
393130001936	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393130001937	domain interaction interfaces [polypeptide binding]; other site
393130001938	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
393130001939	domain interaction interfaces [polypeptide binding]; other site
393130001940	Isochorismatase family; Region: Isochorismatase; pfam00857
393130001941	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
393130001942	catalytic triad [active]
393130001943	conserved cis-peptide bond; other site
393130001944	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130001945	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130001946	PRD domain; Region: PRD; pfam00874
393130001947	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130001948	active site
393130001949	P-loop; other site
393130001950	phosphorylation site [posttranslational modification]
393130001951	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
393130001952	active site
393130001953	phosphorylation site [posttranslational modification]
393130001954	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130001955	active site
393130001956	phosphorylation site [posttranslational modification]
393130001957	putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478
393130001958	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130001959	active site
393130001960	P-loop; other site
393130001961	phosphorylation site [posttranslational modification]
393130001962	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211
393130001963	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
393130001964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130001965	motif II; other site
393130001966	Predicted transcriptional regulator [Transcription]; Region: COG1959
393130001967	Transcriptional regulator; Region: Rrf2; pfam02082
393130001968	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393130001969	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130001970	S-adenosylmethionine binding site [chemical binding]; other site
393130001971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393130001972	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
393130001973	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
393130001974	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130001975	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130001976	active site
393130001977	catalytic tetrad [active]
393130001978	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
393130001979	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130001980	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130001981	motif II; other site
393130001982	Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176
393130001983	catalytic residue [active]
393130001984	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
393130001985	Sulfatase; Region: Sulfatase; pfam00884
393130001986	amino acid transporter; Region: 2A0306; TIGR00909
393130001987	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
393130001988	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
393130001989	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
393130001990	putative metal binding site [ion binding]; other site
393130001991	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
393130001992	active site
393130001993	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
393130001994	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393130001995	Cl binding site [ion binding]; other site
393130001996	oligomer interface [polypeptide binding]; other site
393130001997	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393130001998	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130001999	DNA-binding site [nucleotide binding]; DNA binding site
393130002000	Predicted membrane protein [Function unknown]; Region: COG1511
393130002001	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393130002002	Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488
393130002003	linker region; other site
393130002004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002005	Transcriptional regulators [Transcription]; Region: FadR; COG2186
393130002006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002007	DNA-binding site [nucleotide binding]; DNA binding site
393130002008	FCD domain; Region: FCD; cl11656
393130002009	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393130002010	Predicted integral membrane protein [Function unknown]; Region: COG5523
393130002011	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393130002012	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
393130002013	active site
393130002014	metal binding site [ion binding]; metal-binding site
393130002015	Predicted membrane protein [Function unknown]; Region: COG2322
393130002016	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
393130002017	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393130002018	minor groove reading motif; other site
393130002019	helix-hairpin-helix signature motif; other site
393130002020	substrate binding pocket [chemical binding]; other site
393130002021	active site
393130002022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130002023	non-specific DNA binding site [nucleotide binding]; other site
393130002024	salt bridge; other site
393130002025	sequence-specific DNA binding site [nucleotide binding]; other site
393130002026	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393130002027	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
393130002028	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
393130002029	dimer interface [polypeptide binding]; other site
393130002030	substrate binding site [chemical binding]; other site
393130002031	ATP binding site [chemical binding]; other site
393130002032	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130002033	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130002034	active site
393130002035	motif I; other site
393130002036	motif II; other site
393130002037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130002038	maltose O-acetyltransferase; Provisional; Region: PRK10092
393130002039	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
393130002040	active site
393130002041	substrate binding site [chemical binding]; other site
393130002042	trimer interface [polypeptide binding]; other site
393130002043	CoA binding site [chemical binding]; other site
393130002044	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
393130002045	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130002046	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130002047	Walker A/P-loop; other site
393130002048	ATP binding site [chemical binding]; other site
393130002049	Q-loop/lid; other site
393130002050	ABC transporter signature motif; other site
393130002051	Walker B; other site
393130002052	D-loop; other site
393130002053	H-loop/switch region; other site
393130002054	inner membrane transport permease; Provisional; Region: PRK15066
393130002055	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393130002056	oxidoreductase; Provisional; Region: PRK07985
393130002057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393130002058	NAD(P) binding site [chemical binding]; other site
393130002059	active site
393130002060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
393130002061	Predicted membrane protein [Function unknown]; Region: COG3152
393130002062	DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181
393130002063	Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338
393130002064	Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987
393130002065	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
393130002066	Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377
393130002067	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
393130002068	Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298
393130002069	FHIPEP family; Region: FHIPEP; pfam00771
393130002070	flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726
393130002071	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393130002072	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819
393130002073	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393130002074	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
393130002075	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
393130002076	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
393130002077	Protein of unknown function (DUF3964); Region: DUF3964; pfam13107
393130002078	flagellar motor protein MotA; Validated; Region: PRK08124
393130002079	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
393130002080	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
393130002081	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
393130002082	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
393130002083	ligand binding site [chemical binding]; other site
393130002084	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
393130002085	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
393130002086	putative metal binding site; other site
393130002087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130002088	binding surface
393130002089	TPR motif; other site
393130002090	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
393130002091	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
393130002092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130002093	active site
393130002094	phosphorylation site [posttranslational modification]
393130002095	intermolecular recognition site; other site
393130002096	dimerization interface [polypeptide binding]; other site
393130002097	flagellin; Provisional; Region: PRK12805
393130002098	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
393130002099	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
393130002100	Response regulator receiver domain; Region: Response_reg; pfam00072
393130002101	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130002102	active site
393130002103	phosphorylation site [posttranslational modification]
393130002104	intermolecular recognition site; other site
393130002105	dimerization interface [polypeptide binding]; other site
393130002106	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
393130002107	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
393130002108	putative binding surface; other site
393130002109	active site
393130002110	P2 response regulator binding domain; Region: P2; pfam07194
393130002111	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
393130002112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130002113	ATP binding site [chemical binding]; other site
393130002114	Mg2+ binding site [ion binding]; other site
393130002115	G-X-G motif; other site
393130002116	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
393130002117	flagellar motor switch protein; Validated; Region: PRK06788
393130002118	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
393130002119	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911
393130002120	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
393130002121	Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749
393130002122	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
393130002123	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
393130002124	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393130002125	flagellar motor switch protein; Validated; Region: PRK06789
393130002126	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
393130002127	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
393130002128	flagellar motor switch protein; Reviewed; Region: PRK06782
393130002129	CheC-like family; Region: CheC; pfam04509
393130002130	CheC-like family; Region: CheC; pfam04509
393130002131	Chemotaxis phosphatase CheX; Region: CheX; cl15816
393130002132	CheC-like family; Region: CheC; pfam04509
393130002133	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
393130002134	Protein of unknown function (DUF327); Region: DUF327; pfam03885
393130002135	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799
393130002136	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393130002137	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073
393130002138	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
393130002139	flagellar capping protein; Validated; Region: fliD; PRK06798
393130002140	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
393130002141	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
393130002142	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
393130002143	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797
393130002144	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558
393130002145	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
393130002146	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699
393130002147	Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766
393130002148	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
393130002149	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
393130002150	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
393130002151	FliG C-terminal domain; Region: FliG_C; pfam01706
393130002152	flagellar assembly protein H; Validated; Region: fliH; PRK06800
393130002153	Flagellar assembly protein FliH; Region: FliH; pfam02108
393130002154	flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793
393130002155	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393130002156	Walker A motif; other site
393130002157	ATP binding site [chemical binding]; other site
393130002158	Walker B motif; other site
393130002159	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
393130002160	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
393130002161	N-acetyl-D-glucosamine binding site [chemical binding]; other site
393130002162	catalytic residue [active]
393130002163	Predicted transcriptional regulators [Transcription]; Region: COG1695
393130002164	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
393130002165	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
393130002166	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
393130002167	pyruvate oxidase; Provisional; Region: PRK08611
393130002168	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
393130002169	PYR/PP interface [polypeptide binding]; other site
393130002170	dimer interface [polypeptide binding]; other site
393130002171	tetramer interface [polypeptide binding]; other site
393130002172	TPP binding site [chemical binding]; other site
393130002173	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393130002174	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
393130002175	TPP-binding site [chemical binding]; other site
393130002176	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
393130002177	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
393130002178	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130002179	dimerization interface [polypeptide binding]; other site
393130002180	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
393130002181	dimer interface [polypeptide binding]; other site
393130002182	putative CheW interface [polypeptide binding]; other site
393130002183	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549
393130002184	putative active site [active]
393130002185	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
393130002186	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
393130002187	glutaminase active site [active]
393130002188	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393130002189	dimer interface [polypeptide binding]; other site
393130002190	active site
393130002191	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393130002192	dimer interface [polypeptide binding]; other site
393130002193	active site
393130002194	FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196
393130002195	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
393130002196	active site
393130002197	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
393130002198	GIY-YIG motif/motif A; other site
393130002199	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002200	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002201	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002202	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130002203	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130002204	non-specific DNA binding site [nucleotide binding]; other site
393130002205	salt bridge; other site
393130002206	sequence-specific DNA binding site [nucleotide binding]; other site
393130002207	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130002208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130002209	DNA binding site [nucleotide binding]
393130002210	domain linker motif; other site
393130002211	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130002212	ligand binding site [chemical binding]; other site
393130002213	dimerization interface [polypeptide binding]; other site
393130002214	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130002215	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130002216	substrate binding site [chemical binding]; other site
393130002217	hexamer interface [polypeptide binding]; other site
393130002218	metal binding site [ion binding]; metal-binding site
393130002219	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
393130002220	BtpA family; Region: BtpA; cl00440
393130002221	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
393130002222	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393130002223	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130002224	active site turn [active]
393130002225	phosphorylation site [posttranslational modification]
393130002226	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130002227	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393130002228	HPr interaction site; other site
393130002229	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130002230	active site
393130002231	phosphorylation site [posttranslational modification]
393130002232	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130002233	beta-galactosidase; Region: BGL; TIGR03356
393130002234	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130002235	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130002236	ligand binding site [chemical binding]; other site
393130002237	flexible hinge region; other site
393130002238	Predicted transcriptional regulators [Transcription]; Region: COG1725
393130002239	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002240	DNA-binding site [nucleotide binding]; DNA binding site
393130002241	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
393130002242	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130002243	Walker A/P-loop; other site
393130002244	ATP binding site [chemical binding]; other site
393130002245	Q-loop/lid; other site
393130002246	ABC transporter signature motif; other site
393130002247	Walker B; other site
393130002248	D-loop; other site
393130002249	H-loop/switch region; other site
393130002250	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130002251	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130002252	Walker A/P-loop; other site
393130002253	ATP binding site [chemical binding]; other site
393130002254	Q-loop/lid; other site
393130002255	ABC transporter signature motif; other site
393130002256	Walker B; other site
393130002257	D-loop; other site
393130002258	H-loop/switch region; other site
393130002259	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130002260	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393130002261	FtsX-like permease family; Region: FtsX; pfam02687
393130002262	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130002263	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130002264	non-specific DNA binding site [nucleotide binding]; other site
393130002265	salt bridge; other site
393130002266	sequence-specific DNA binding site [nucleotide binding]; other site
393130002267	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393130002268	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130002269	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393130002270	ligand binding site [chemical binding]; other site
393130002271	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393130002272	non-specific DNA interactions [nucleotide binding]; other site
393130002273	DNA binding site [nucleotide binding]
393130002274	sequence specific DNA binding site [nucleotide binding]; other site
393130002275	putative cAMP binding site [chemical binding]; other site
393130002276	SnoaL-like domain; Region: SnoaL_4; pfam13577
393130002277	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
393130002278	active site
393130002279	catalytic triad [active]
393130002280	oxyanion hole [active]
393130002281	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130002282	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130002283	Walker A/P-loop; other site
393130002284	ATP binding site [chemical binding]; other site
393130002285	Q-loop/lid; other site
393130002286	ABC transporter signature motif; other site
393130002287	Walker B; other site
393130002288	D-loop; other site
393130002289	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393130002290	H-loop/switch region; other site
393130002291	active site
393130002292	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
393130002293	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393130002294	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393130002295	Zn binding site [ion binding]; other site
393130002296	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393130002297	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130002298	Zn binding site [ion binding]; other site
393130002299	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
393130002300	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130002301	Zn binding site [ion binding]; other site
393130002302	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
393130002303	Zn binding site [ion binding]; other site
393130002304	Predicted esterase [General function prediction only]; Region: COG0400
393130002305	putative hydrolase; Provisional; Region: PRK11460
393130002306	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
393130002307	GTPases [General function prediction only]; Region: HflX; COG2262
393130002308	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
393130002309	HflX GTPase family; Region: HflX; cd01878
393130002310	G1 box; other site
393130002311	GTP/Mg2+ binding site [chemical binding]; other site
393130002312	Switch I region; other site
393130002313	G2 box; other site
393130002314	G3 box; other site
393130002315	Switch II region; other site
393130002316	G4 box; other site
393130002317	G5 box; other site
393130002318	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
393130002319	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393130002320	putative active site [active]
393130002321	putative metal binding site [ion binding]; other site
393130002322	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
393130002323	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393130002324	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
393130002325	Uncharacterized conserved protein [Function unknown]; Region: COG3538
393130002326	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
393130002327	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393130002328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002329	dimer interface [polypeptide binding]; other site
393130002330	conserved gate region; other site
393130002331	putative PBP binding loops; other site
393130002332	ABC-ATPase subunit interface; other site
393130002333	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130002334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002335	dimer interface [polypeptide binding]; other site
393130002336	conserved gate region; other site
393130002337	putative PBP binding loops; other site
393130002338	ABC-ATPase subunit interface; other site
393130002339	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393130002340	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
393130002341	Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833
393130002342	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002343	DNA-binding site [nucleotide binding]; DNA binding site
393130002344	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130002345	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130002346	ligand binding site [chemical binding]; other site
393130002347	dimerization interface [polypeptide binding]; other site
393130002348	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393130002349	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002350	DNA-binding site [nucleotide binding]; DNA binding site
393130002351	Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289
393130002352	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
393130002353	putative NADP binding site [chemical binding]; other site
393130002354	putative dimer interface [polypeptide binding]; other site
393130002355	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
393130002356	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393130002357	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130002358	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130002359	nucleotide binding site [chemical binding]; other site
393130002360	Predicted membrane protein [Function unknown]; Region: COG4811
393130002361	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
393130002362	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
393130002363	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393130002364	active site
393130002365	phosphorylation site [posttranslational modification]
393130002366	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130002367	active pocket/dimerization site; other site
393130002368	active site
393130002369	phosphorylation site [posttranslational modification]
393130002370	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
393130002371	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130002372	Walker A motif; other site
393130002373	ATP binding site [chemical binding]; other site
393130002374	Walker B motif; other site
393130002375	arginine finger; other site
393130002376	Transcriptional antiterminator [Transcription]; Region: COG3933
393130002377	PRD domain; Region: PRD; pfam00874
393130002378	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130002379	active pocket/dimerization site; other site
393130002380	active site
393130002381	phosphorylation site [posttranslational modification]
393130002382	PRD domain; Region: PRD; pfam00874
393130002383	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
393130002384	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393130002385	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
393130002386	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393130002387	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
393130002388	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393130002389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
393130002390	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
393130002391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
393130002392	Leucine rich repeat; Region: LRR_8; pfam13855
393130002393	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002394	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002395	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002396	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002397	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130002398	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
393130002399	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393130002400	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
393130002401	putative deacylase active site [active]
393130002402	Predicted amidohydrolase [General function prediction only]; Region: COG0388
393130002403	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
393130002404	active site
393130002405	catalytic triad [active]
393130002406	dimer interface [polypeptide binding]; other site
393130002407	Protein of unknown function (DUF554); Region: DUF554; pfam04474
393130002408	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
393130002409	NADH(P)-binding; Region: NAD_binding_10; pfam13460
393130002410	NAD binding site [chemical binding]; other site
393130002411	substrate binding site [chemical binding]; other site
393130002412	putative active site [active]
393130002413	Predicted permeases [General function prediction only]; Region: RarD; COG2962
393130002414	EamA-like transporter family; Region: EamA; pfam00892
393130002415	Uncharacterized conserved protein [Function unknown]; Region: COG2353
393130002416	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393130002417	MarR family; Region: MarR_2; pfam12802
393130002418	lysine transporter; Provisional; Region: PRK10836
393130002419	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393130002420	PAS domain; Region: PAS_9; pfam13426
393130002421	putative active site [active]
393130002422	heme pocket [chemical binding]; other site
393130002423	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130002424	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
393130002425	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130002426	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130002427	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130002428	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130002429	LRR adjacent; Region: LRR_adjacent; pfam08191
393130002430	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130002431	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130002432	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393130002433	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393130002434	synthetase active site [active]
393130002435	NTP binding site [chemical binding]; other site
393130002436	metal binding site [ion binding]; metal-binding site
393130002437	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
393130002438	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
393130002439	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130002440	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130002441	non-specific DNA binding site [nucleotide binding]; other site
393130002442	salt bridge; other site
393130002443	sequence-specific DNA binding site [nucleotide binding]; other site
393130002444	Cupin domain; Region: Cupin_2; pfam07883
393130002445	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
393130002446	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
393130002447	Walker A/P-loop; other site
393130002448	ATP binding site [chemical binding]; other site
393130002449	Q-loop/lid; other site
393130002450	ABC transporter signature motif; other site
393130002451	Walker B; other site
393130002452	D-loop; other site
393130002453	H-loop/switch region; other site
393130002454	TOBE domain; Region: TOBE_2; pfam08402
393130002455	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
393130002456	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002457	putative PBP binding loops; other site
393130002458	ABC-ATPase subunit interface; other site
393130002459	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
393130002460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002461	dimer interface [polypeptide binding]; other site
393130002462	conserved gate region; other site
393130002463	putative PBP binding loops; other site
393130002464	ABC-ATPase subunit interface; other site
393130002465	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
393130002466	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
393130002467	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
393130002468	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
393130002469	active site
393130002470	zinc binding site [ion binding]; other site
393130002471	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393130002472	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130002473	Zn2+ binding site [ion binding]; other site
393130002474	Mg2+ binding site [ion binding]; other site
393130002475	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130002476	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130002477	nucleotide binding site [chemical binding]; other site
393130002478	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
393130002479	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
393130002480	FMN binding site [chemical binding]; other site
393130002481	substrate binding site [chemical binding]; other site
393130002482	putative catalytic residue [active]
393130002483	Protein of unknown function (DUF3130; Region: DUF3130; pfam11328
393130002484	LXG domain of WXG superfamily; Region: LXG; pfam04740
393130002485	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393130002486	dimer interface [polypeptide binding]; other site
393130002487	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130002488	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
393130002489	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
393130002490	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130002491	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393130002492	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130002493	motif II; other site
393130002494	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393130002495	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130002496	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130002497	Coenzyme A binding pocket [chemical binding]; other site
393130002498	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
393130002499	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130002500	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130002501	DNA binding residues [nucleotide binding]
393130002502	putative dimer interface [polypeptide binding]; other site
393130002503	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130002504	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130002505	active site
393130002506	catalytic tetrad [active]
393130002507	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
393130002508	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
393130002509	homodimer interface [polypeptide binding]; other site
393130002510	catalytic residues [active]
393130002511	NAD binding site [chemical binding]; other site
393130002512	substrate binding pocket [chemical binding]; other site
393130002513	flexible flap; other site
393130002514	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
393130002515	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
393130002516	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
393130002517	PhoU domain; Region: PhoU; pfam01895
393130002518	PhoU domain; Region: PhoU; pfam01895
393130002519	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
393130002520	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
393130002521	dimer interface [polypeptide binding]; other site
393130002522	PYR/PP interface [polypeptide binding]; other site
393130002523	TPP binding site [chemical binding]; other site
393130002524	substrate binding site [chemical binding]; other site
393130002525	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
393130002526	Domain of unknown function; Region: EKR; smart00890
393130002527	4Fe-4S binding domain; Region: Fer4_6; pfam12837
393130002528	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
393130002529	TPP-binding site [chemical binding]; other site
393130002530	dimer interface [polypeptide binding]; other site
393130002531	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
393130002532	Predicted permeases [General function prediction only]; Region: COG0679
393130002533	Helix-turn-helix domain; Region: HTH_28; pfam13518
393130002534	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130002535	non-specific DNA binding site [nucleotide binding]; other site
393130002536	salt bridge; other site
393130002537	sequence-specific DNA binding site [nucleotide binding]; other site
393130002538	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393130002539	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002540	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130002541	Predicted membrane protein [Function unknown]; Region: COG3223
393130002542	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130002543	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
393130002544	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
393130002545	Walker A/P-loop; other site
393130002546	ATP binding site [chemical binding]; other site
393130002547	Q-loop/lid; other site
393130002548	ABC transporter signature motif; other site
393130002549	Walker B; other site
393130002550	D-loop; other site
393130002551	H-loop/switch region; other site
393130002552	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
393130002553	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002554	putative substrate translocation pore; other site
393130002555	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002557	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130002558	putative substrate translocation pore; other site
393130002559	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130002560	MarR family; Region: MarR; pfam01047
393130002561	MarR family; Region: MarR_2; cl17246
393130002562	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
393130002563	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
393130002564	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130002565	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393130002566	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130002567	motif II; other site
393130002568	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393130002569	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002570	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002571	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002572	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002573	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002574	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002575	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
393130002576	Predicted membrane protein [Function unknown]; Region: COG3326
393130002577	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
393130002578	homotrimer interaction site [polypeptide binding]; other site
393130002579	putative active site [active]
393130002580	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
393130002581	substrate binding site [chemical binding]; other site
393130002582	zinc-binding site [ion binding]; other site
393130002583	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
393130002584	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
393130002585	GIY-YIG motif/motif A; other site
393130002586	active site
393130002587	catalytic site [active]
393130002588	putative DNA binding site [nucleotide binding]; other site
393130002589	metal binding site [ion binding]; metal-binding site
393130002590	UvrB/uvrC motif; Region: UVR; pfam02151
393130002591	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393130002592	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393130002593	substrate binding pocket [chemical binding]; other site
393130002594	membrane-bound complex binding site; other site
393130002595	hinge residues; other site
393130002596	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393130002597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002598	dimer interface [polypeptide binding]; other site
393130002599	conserved gate region; other site
393130002600	putative PBP binding loops; other site
393130002601	ABC-ATPase subunit interface; other site
393130002602	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393130002603	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393130002604	Walker A/P-loop; other site
393130002605	ATP binding site [chemical binding]; other site
393130002606	Q-loop/lid; other site
393130002607	ABC transporter signature motif; other site
393130002608	Walker B; other site
393130002609	D-loop; other site
393130002610	H-loop/switch region; other site
393130002611	amidase; Provisional; Region: PRK11910
393130002612	Amidase; Region: Amidase; cl11426
393130002613	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130002614	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130002615	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
393130002616	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
393130002617	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
393130002618	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
393130002619	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
393130002620	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
393130002621	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393130002622	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393130002623	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
393130002624	Esterase/lipase [General function prediction only]; Region: COG1647
393130002625	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130002626	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130002627	DNA binding site [nucleotide binding]
393130002628	domain linker motif; other site
393130002629	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277
393130002630	putative dimerization interface [polypeptide binding]; other site
393130002631	putative ligand binding site [chemical binding]; other site
393130002632	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393130002633	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130002634	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
393130002635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002636	dimer interface [polypeptide binding]; other site
393130002637	conserved gate region; other site
393130002638	putative PBP binding loops; other site
393130002639	ABC-ATPase subunit interface; other site
393130002640	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130002641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130002642	dimer interface [polypeptide binding]; other site
393130002643	conserved gate region; other site
393130002644	ABC-ATPase subunit interface; other site
393130002645	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393130002646	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393130002647	Ca binding site [ion binding]; other site
393130002648	active site
393130002649	catalytic site [active]
393130002650	Protein of unknown function (DUF1861); Region: DUF1861; pfam08950
393130002651	Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152
393130002652	active site
393130002653	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
393130002654	active site
393130002655	substrate binding site [chemical binding]; other site
393130002656	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
393130002657	metal binding site [ion binding]; metal-binding site
393130002658	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393130002659	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393130002660	ATP binding site [chemical binding]; other site
393130002661	Mg++ binding site [ion binding]; other site
393130002662	motif III; other site
393130002663	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130002664	nucleotide binding region [chemical binding]; other site
393130002665	ATP-binding site [chemical binding]; other site
393130002666	Predicted membrane protein [Function unknown]; Region: COG4708
393130002667	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
393130002668	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078
393130002669	Predicted transcriptional regulators [Transcription]; Region: COG1733
393130002670	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
393130002671	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
393130002672	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002673	putative substrate translocation pore; other site
393130002674	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130002675	PRD domain; Region: PRD; pfam00874
393130002676	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130002677	active site
393130002678	P-loop; other site
393130002679	phosphorylation site [posttranslational modification]
393130002680	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130002681	active site
393130002682	phosphorylation site [posttranslational modification]
393130002683	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130002684	methionine cluster; other site
393130002685	active site
393130002686	phosphorylation site [posttranslational modification]
393130002687	metal binding site [ion binding]; metal-binding site
393130002688	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130002689	active site
393130002690	P-loop; other site
393130002691	phosphorylation site [posttranslational modification]
393130002692	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130002693	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130002694	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393130002695	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393130002696	active site
393130002697	trimer interface [polypeptide binding]; other site
393130002698	allosteric site; other site
393130002699	active site lid [active]
393130002700	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393130002701	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130002702	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130002703	active site
393130002704	catalytic tetrad [active]
393130002705	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
393130002706	Collagen binding domain; Region: Collagen_bind; pfam05737
393130002707	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
393130002708	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130002709	Uncharacterized conserved protein [Function unknown]; Region: COG3402
393130002710	Predicted membrane protein [Function unknown]; Region: COG3428
393130002711	Bacterial PH domain; Region: DUF304; pfam03703
393130002712	Bacterial PH domain; Region: DUF304; pfam03703
393130002713	Bacterial PH domain; Region: DUF304; pfam03703
393130002714	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
393130002715	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
393130002716	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
393130002717	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
393130002718	active site
393130002719	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393130002720	dimer interface [polypeptide binding]; other site
393130002721	substrate binding site [chemical binding]; other site
393130002722	catalytic residues [active]
393130002723	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
393130002724	PemK-like protein; Region: PemK; pfam02452
393130002725	Rsbr N terminal; Region: Rsbr_N; pfam08678
393130002726	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130002727	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130002728	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
393130002729	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
393130002730	ATP binding site [chemical binding]; other site
393130002731	Mg2+ binding site [ion binding]; other site
393130002732	G-X-G motif; other site
393130002733	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
393130002734	Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673
393130002735	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
393130002736	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
393130002737	anti sigma factor interaction site; other site
393130002738	regulatory phosphorylation site [posttranslational modification]; other site
393130002739	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
393130002740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130002741	ATP binding site [chemical binding]; other site
393130002742	Mg2+ binding site [ion binding]; other site
393130002743	G-X-G motif; other site
393130002744	RNA polymerase sigma factor SigB; Validated; Region: PRK08583
393130002745	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393130002746	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
393130002747	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393130002748	DNA binding residues [nucleotide binding]
393130002749	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
393130002750	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
393130002751	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
393130002752	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393130002753	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
393130002754	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
393130002755	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
393130002756	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
393130002757	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
393130002758	RNA binding site [nucleotide binding]; other site
393130002759	hypothetical protein; Provisional; Region: PRK04351
393130002760	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
393130002761	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
393130002762	Uncharacterized conserved protein [Function unknown]; Region: COG5646
393130002763	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130002764	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130002765	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130002766	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002767	DNA-binding site [nucleotide binding]; DNA binding site
393130002768	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393130002769	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
393130002770	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
393130002771	Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350
393130002772	glutathione reductase; Validated; Region: PRK06116
393130002773	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130002774	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130002775	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393130002776	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130002777	catalytic core [active]
393130002778	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393130002779	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393130002780	Predicted transcriptional regulators [Transcription]; Region: COG1725
393130002781	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002782	DNA-binding site [nucleotide binding]; DNA binding site
393130002783	Predicted membrane protein [General function prediction only]; Region: COG4194
393130002784	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
393130002785	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
393130002786	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
393130002787	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
393130002788	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
393130002789	tetramerization interface [polypeptide binding]; other site
393130002790	NAD(P) binding site [chemical binding]; other site
393130002791	catalytic residues [active]
393130002792	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
393130002793	active site
393130002794	P-loop; other site
393130002795	phosphorylation site [posttranslational modification]
393130002796	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130002797	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130002798	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130002799	methionine cluster; other site
393130002800	active site
393130002801	phosphorylation site [posttranslational modification]
393130002802	metal binding site [ion binding]; metal-binding site
393130002803	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130002804	beta-galactosidase; Region: BGL; TIGR03356
393130002805	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130002806	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130002807	PRD domain; Region: PRD; pfam00874
393130002808	PRD domain; Region: PRD; pfam00874
393130002809	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130002810	active site
393130002811	phosphorylation site [posttranslational modification]
393130002812	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130002813	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
393130002814	ABC transporter; Region: ABC_tran_2; pfam12848
393130002815	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130002816	heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189
393130002817	Predicted permeases [General function prediction only]; Region: COG0701
393130002818	Predicted membrane protein [Function unknown]; Region: COG3689
393130002819	pantothenate kinase; Provisional; Region: PRK05439
393130002820	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
393130002821	ATP-binding site [chemical binding]; other site
393130002822	CoA-binding site [chemical binding]; other site
393130002823	Mg2+-binding site [ion binding]; other site
393130002824	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
393130002825	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130002826	Walker A/P-loop; other site
393130002827	ATP binding site [chemical binding]; other site
393130002828	Q-loop/lid; other site
393130002829	ABC transporter signature motif; other site
393130002830	Walker B; other site
393130002831	D-loop; other site
393130002832	H-loop/switch region; other site
393130002833	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393130002834	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393130002835	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130002836	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130002837	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
393130002838	Domain of unknown function (DUF373); Region: DUF373; cl12079
393130002839	Sulfatase; Region: Sulfatase; pfam00884
393130002840	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
393130002841	active site
393130002842	DNA binding site [nucleotide binding]
393130002843	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
393130002844	active site
393130002845	catalytic site [active]
393130002846	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
393130002847	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393130002848	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
393130002849	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
393130002850	Uncharacterized conserved protein [Function unknown]; Region: COG0398
393130002851	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393130002852	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
393130002853	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
393130002854	Ligand binding site; other site
393130002855	Putative Catalytic site; other site
393130002856	DXD motif; other site
393130002857	epoxyqueuosine reductase; Region: TIGR00276
393130002858	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
393130002859	A new structural DNA glycosylase; Region: AlkD_like; cl11434
393130002860	active site
393130002861	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
393130002862	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393130002863	dimer interface [polypeptide binding]; other site
393130002864	FMN binding site [chemical binding]; other site
393130002865	NADPH bind site [chemical binding]; other site
393130002866	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393130002867	Low molecular weight phosphatase family; Region: LMWPc; cd00115
393130002868	active site
393130002869	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
393130002870	HSP90 family protein; Provisional; Region: PRK14083
393130002871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130002872	ATP binding site [chemical binding]; other site
393130002873	Mg2+ binding site [ion binding]; other site
393130002874	G-X-G motif; other site
393130002875	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
393130002876	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
393130002877	dimerization interface [polypeptide binding]; other site
393130002878	DPS ferroxidase diiron center [ion binding]; other site
393130002879	ion pore; other site
393130002880	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841
393130002881	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
393130002882	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130002883	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
393130002884	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
393130002885	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
393130002886	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
393130002887	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002888	putative substrate translocation pore; other site
393130002889	Transcriptional regulators [Transcription]; Region: FadR; COG2186
393130002890	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002891	DNA-binding site [nucleotide binding]; DNA binding site
393130002892	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
393130002893	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393130002894	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393130002895	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
393130002896	Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814
393130002897	Protein of unknown function (DUF4064); Region: DUF4064; pfam13273
393130002898	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
393130002899	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
393130002900	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
393130002901	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
393130002902	active site
393130002903	dimer interface [polypeptide binding]; other site
393130002904	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393130002905	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393130002906	active site
393130002907	trimer interface [polypeptide binding]; other site
393130002908	allosteric site; other site
393130002909	active site lid [active]
393130002910	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393130002911	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130002912	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130002913	DNA-binding site [nucleotide binding]; DNA binding site
393130002914	UTRA domain; Region: UTRA; pfam07702
393130002915	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
393130002916	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
393130002917	Mg++ binding site [ion binding]; other site
393130002918	putative catalytic motif [active]
393130002919	substrate binding site [chemical binding]; other site
393130002920	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
393130002921	Peptidase family U32; Region: Peptidase_U32; pfam01136
393130002922	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
393130002923	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393130002924	Peptidase family U32; Region: Peptidase_U32; pfam01136
393130002925	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
393130002926	heat shock protein HtpX; Provisional; Region: PRK04897
393130002927	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
393130002928	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
393130002929	catalytic residues [active]
393130002930	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
393130002931	putative active site [active]
393130002932	putative metal binding residues [ion binding]; other site
393130002933	signature motif; other site
393130002934	putative triphosphate binding site [ion binding]; other site
393130002935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130002936	TPR motif; other site
393130002937	binding surface
393130002938	TPR repeat; Region: TPR_11; pfam13414
393130002939	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393130002940	synthetase active site [active]
393130002941	NTP binding site [chemical binding]; other site
393130002942	metal binding site [ion binding]; metal-binding site
393130002943	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
393130002944	ATP-NAD kinase; Region: NAD_kinase; pfam01513
393130002945	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393130002946	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393130002947	active site
393130002948	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
393130002949	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
393130002950	NAD binding site [chemical binding]; other site
393130002951	homotetramer interface [polypeptide binding]; other site
393130002952	homodimer interface [polypeptide binding]; other site
393130002953	substrate binding site [chemical binding]; other site
393130002954	active site
393130002955	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
393130002956	DltD N-terminal region; Region: DltD_N; pfam04915
393130002957	DltD central region; Region: DltD_M; pfam04918
393130002958	DltD C-terminal region; Region: DltD_C; pfam04914
393130002959	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
393130002960	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
393130002961	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
393130002962	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
393130002963	acyl-activating enzyme (AAE) consensus motif; other site
393130002964	AMP binding site [chemical binding]; other site
393130002965	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
393130002966	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
393130002967	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130002968	active site
393130002969	dimer interface [polypeptide binding]; other site
393130002970	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130002971	Coenzyme A binding pocket [chemical binding]; other site
393130002972	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
393130002973	Putative esterase; Region: Esterase; pfam00756
393130002974	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
393130002975	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
393130002976	homodimer interface [polypeptide binding]; other site
393130002977	substrate-cofactor binding pocket; other site
393130002978	catalytic residue [active]
393130002979	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393130002980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130002981	Walker A/P-loop; other site
393130002982	ATP binding site [chemical binding]; other site
393130002983	Q-loop/lid; other site
393130002984	ABC transporter signature motif; other site
393130002985	Walker B; other site
393130002986	D-loop; other site
393130002987	H-loop/switch region; other site
393130002988	ABC-2 type transporter; Region: ABC2_membrane; cl17235
393130002989	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
393130002990	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130002991	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130002992	putative substrate translocation pore; other site
393130002993	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393130002994	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
393130002995	putative oligomer interface [polypeptide binding]; other site
393130002996	putative active site [active]
393130002997	metal binding site [ion binding]; metal-binding site
393130002998	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
393130002999	catalytic residues [active]
393130003000	dimer interface [polypeptide binding]; other site
393130003001	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
393130003002	LytTr DNA-binding domain; Region: LytTR; pfam04397
393130003003	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130003004	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130003005	Walker A/P-loop; other site
393130003006	ATP binding site [chemical binding]; other site
393130003007	Q-loop/lid; other site
393130003008	ABC transporter signature motif; other site
393130003009	Walker B; other site
393130003010	D-loop; other site
393130003011	H-loop/switch region; other site
393130003012	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
393130003013	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393130003014	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
393130003015	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
393130003016	G1 box; other site
393130003017	putative GEF interaction site [polypeptide binding]; other site
393130003018	GTP/Mg2+ binding site [chemical binding]; other site
393130003019	Switch I region; other site
393130003020	G2 box; other site
393130003021	G3 box; other site
393130003022	Switch II region; other site
393130003023	G4 box; other site
393130003024	G5 box; other site
393130003025	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
393130003026	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130003027	MarR family; Region: MarR_2; cl17246
393130003028	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393130003029	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393130003030	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
393130003031	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
393130003032	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
393130003033	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
393130003034	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
393130003035	Acyltransferase family; Region: Acyl_transf_3; pfam01757
393130003036	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393130003037	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393130003038	DNA binding site [nucleotide binding]
393130003039	active site
393130003040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130003041	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
393130003042	Walker A motif; other site
393130003043	ATP binding site [chemical binding]; other site
393130003044	Walker B motif; other site
393130003045	arginine finger; other site
393130003046	UvrB/uvrC motif; Region: UVR; pfam02151
393130003047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130003048	Walker A motif; other site
393130003049	ATP binding site [chemical binding]; other site
393130003050	Walker B motif; other site
393130003051	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
393130003052	CAAX protease self-immunity; Region: Abi; pfam02517
393130003053	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
393130003054	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393130003055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873
393130003056	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
393130003057	dimerization domain swap beta strand [polypeptide binding]; other site
393130003058	regulatory protein interface [polypeptide binding]; other site
393130003059	active site
393130003060	regulatory phosphorylation site [posttranslational modification]; other site
393130003061	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
393130003062	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
393130003063	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393130003064	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
393130003065	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
393130003066	Uncharacterized conserved protein [Function unknown]; Region: COG1434
393130003067	putative active site [active]
393130003068	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
393130003069	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
393130003070	aminotransferase A; Validated; Region: PRK07683
393130003071	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130003072	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130003073	homodimer interface [polypeptide binding]; other site
393130003074	catalytic residue [active]
393130003075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
393130003076	FOG: CBS domain [General function prediction only]; Region: COG0517
393130003077	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
393130003078	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130003079	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130003080	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393130003081	dimerization interface [polypeptide binding]; other site
393130003082	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
393130003083	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
393130003084	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393130003085	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393130003086	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393130003087	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
393130003088	metal binding site [ion binding]; metal-binding site
393130003089	putative dimer interface [polypeptide binding]; other site
393130003090	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
393130003091	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
393130003092	Mechanosensitive ion channel; Region: MS_channel; pfam00924
393130003093	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
393130003094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130003095	Walker A/P-loop; other site
393130003096	ATP binding site [chemical binding]; other site
393130003097	Q-loop/lid; other site
393130003098	ABC transporter signature motif; other site
393130003099	Walker B; other site
393130003100	D-loop; other site
393130003101	H-loop/switch region; other site
393130003102	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393130003103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130003104	dimer interface [polypeptide binding]; other site
393130003105	conserved gate region; other site
393130003106	putative PBP binding loops; other site
393130003107	ABC-ATPase subunit interface; other site
393130003108	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
393130003109	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393130003110	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393130003111	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
393130003112	HPr interaction site; other site
393130003113	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130003114	active site
393130003115	phosphorylation site [posttranslational modification]
393130003116	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
393130003117	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
393130003118	S1 domain; Region: S1_2; pfam13509
393130003119	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
393130003120	RNA binding site [nucleotide binding]; other site
393130003121	Predicted membrane protein [Function unknown]; Region: COG4758
393130003122	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
393130003123	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
393130003124	Histidine kinase; Region: HisKA_3; pfam07730
393130003125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130003126	ATP binding site [chemical binding]; other site
393130003127	Mg2+ binding site [ion binding]; other site
393130003128	G-X-G motif; other site
393130003129	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
393130003130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130003131	active site
393130003132	phosphorylation site [posttranslational modification]
393130003133	intermolecular recognition site; other site
393130003134	dimerization interface [polypeptide binding]; other site
393130003135	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
393130003136	DNA binding residues [nucleotide binding]
393130003137	dimerization interface [polypeptide binding]; other site
393130003138	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
393130003139	TrkA-N domain; Region: TrkA_N; pfam02254
393130003140	TrkA-C domain; Region: TrkA_C; pfam02080
393130003141	Predicted membrane protein [Function unknown]; Region: COG1289
393130003142	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
393130003143	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
393130003144	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
393130003145	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393130003146	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
393130003147	hypothetical protein; Provisional; Region: PRK13667
393130003148	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130003149	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130003150	active site
393130003151	motif I; other site
393130003152	motif II; other site
393130003153	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130003154	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130003155	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130003156	DNA binding site [nucleotide binding]
393130003157	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130003158	ligand binding site [chemical binding]; other site
393130003159	dimerization interface [polypeptide binding]; other site
393130003160	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
393130003161	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393130003162	trimer interface [polypeptide binding]; other site
393130003163	substrate binding site [chemical binding]; other site
393130003164	Mn binding site [ion binding]; other site
393130003165	transketolase; Reviewed; Region: PRK05899
393130003166	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393130003167	TPP-binding site [chemical binding]; other site
393130003168	dimer interface [polypeptide binding]; other site
393130003169	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
393130003170	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130003171	PYR/PP interface [polypeptide binding]; other site
393130003172	dimer interface [polypeptide binding]; other site
393130003173	TPP binding site [chemical binding]; other site
393130003174	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130003175	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
393130003176	Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427
393130003177	N- and C-terminal domain interface [polypeptide binding]; other site
393130003178	active site
393130003179	MgATP binding site [chemical binding]; other site
393130003180	catalytic site [active]
393130003181	metal binding site [ion binding]; metal-binding site
393130003182	putative glycerol binding site [chemical binding]; other site
393130003183	putative homotetramer interface [polypeptide binding]; other site
393130003184	putative homodimer interface [polypeptide binding]; other site
393130003185	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393130003186	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130003187	active site turn [active]
393130003188	phosphorylation site [posttranslational modification]
393130003189	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130003190	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393130003191	HPr interaction site; other site
393130003192	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130003193	active site
393130003194	phosphorylation site [posttranslational modification]
393130003195	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
393130003196	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
393130003197	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
393130003198	GTP binding site; other site
393130003199	ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297
393130003200	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
393130003201	Walker A/P-loop; other site
393130003202	ATP binding site [chemical binding]; other site
393130003203	Q-loop/lid; other site
393130003204	ABC transporter signature motif; other site
393130003205	Walker B; other site
393130003206	D-loop; other site
393130003207	H-loop/switch region; other site
393130003208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130003209	dimer interface [polypeptide binding]; other site
393130003210	conserved gate region; other site
393130003211	putative PBP binding loops; other site
393130003212	ABC-ATPase subunit interface; other site
393130003213	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
393130003214	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
393130003215	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
393130003216	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
393130003217	dimer interface [polypeptide binding]; other site
393130003218	putative functional site; other site
393130003219	putative MPT binding site; other site
393130003220	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
393130003221	Walker A motif; other site
393130003222	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
393130003223	MoaE homodimer interface [polypeptide binding]; other site
393130003224	MoaD interaction [polypeptide binding]; other site
393130003225	active site residues [active]
393130003226	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
393130003227	MoaE interaction surface [polypeptide binding]; other site
393130003228	MoeB interaction surface [polypeptide binding]; other site
393130003229	thiocarboxylated glycine; other site
393130003230	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
393130003231	trimer interface [polypeptide binding]; other site
393130003232	dimer interface [polypeptide binding]; other site
393130003233	putative active site [active]
393130003234	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
393130003235	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393130003236	FeS/SAM binding site; other site
393130003237	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
393130003238	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
393130003239	MPT binding site; other site
393130003240	trimer interface [polypeptide binding]; other site
393130003241	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
393130003242	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
393130003243	ATP binding site [chemical binding]; other site
393130003244	substrate interface [chemical binding]; other site
393130003245	Flavin Reductases; Region: FlaRed; cl00801
393130003246	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
393130003247	active site
393130003248	catalytic residues [active]
393130003249	metal binding site [ion binding]; metal-binding site
393130003250	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
393130003251	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
393130003252	TPP-binding site [chemical binding]; other site
393130003253	tetramer interface [polypeptide binding]; other site
393130003254	heterodimer interface [polypeptide binding]; other site
393130003255	phosphorylation loop region [posttranslational modification]
393130003256	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
393130003257	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
393130003258	alpha subunit interface [polypeptide binding]; other site
393130003259	TPP binding site [chemical binding]; other site
393130003260	heterodimer interface [polypeptide binding]; other site
393130003261	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130003262	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855
393130003263	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393130003264	E3 interaction surface; other site
393130003265	lipoyl attachment site [posttranslational modification]; other site
393130003266	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393130003267	E3 interaction surface; other site
393130003268	lipoyl attachment site [posttranslational modification]; other site
393130003269	e3 binding domain; Region: E3_binding; pfam02817
393130003270	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
393130003271	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
393130003272	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393130003273	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130003274	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393130003275	Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039
393130003276	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
393130003277	NAD(P) binding site [chemical binding]; other site
393130003278	LDH/MDH dimer interface [polypeptide binding]; other site
393130003279	substrate binding site [chemical binding]; other site
393130003280	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476
393130003281	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
393130003282	Thioredoxin; Region: Thioredoxin_4; pfam13462
393130003283	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130003284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130003285	active site
393130003286	phosphorylation site [posttranslational modification]
393130003287	intermolecular recognition site; other site
393130003288	dimerization interface [polypeptide binding]; other site
393130003289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130003290	DNA binding site [nucleotide binding]
393130003291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393130003292	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130003293	dimerization interface [polypeptide binding]; other site
393130003294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130003295	dimer interface [polypeptide binding]; other site
393130003296	phosphorylation site [posttranslational modification]
393130003297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130003298	ATP binding site [chemical binding]; other site
393130003299	Mg2+ binding site [ion binding]; other site
393130003300	G-X-G motif; other site
393130003301	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130003302	FtsX-like permease family; Region: FtsX; pfam02687
393130003303	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130003304	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130003305	Walker A/P-loop; other site
393130003306	ATP binding site [chemical binding]; other site
393130003307	Q-loop/lid; other site
393130003308	ABC transporter signature motif; other site
393130003309	Walker B; other site
393130003310	D-loop; other site
393130003311	H-loop/switch region; other site
393130003312	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
393130003313	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
393130003314	Cl binding site [ion binding]; other site
393130003315	oligomer interface [polypeptide binding]; other site
393130003316	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
393130003317	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
393130003318	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
393130003319	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
393130003320	active site
393130003321	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
393130003322	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
393130003323	G1 box; other site
393130003324	putative GEF interaction site [polypeptide binding]; other site
393130003325	GTP/Mg2+ binding site [chemical binding]; other site
393130003326	Switch I region; other site
393130003327	G2 box; other site
393130003328	G3 box; other site
393130003329	Switch II region; other site
393130003330	G4 box; other site
393130003331	G5 box; other site
393130003332	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
393130003333	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
393130003334	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896
393130003335	hypothetical protein; Provisional; Region: PRK13666
393130003336	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393130003337	pyruvate carboxylase; Reviewed; Region: PRK12999
393130003338	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393130003339	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
393130003340	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
393130003341	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
393130003342	active site
393130003343	catalytic residues [active]
393130003344	metal binding site [ion binding]; metal-binding site
393130003345	homodimer binding site [polypeptide binding]; other site
393130003346	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
393130003347	carboxyltransferase (CT) interaction site; other site
393130003348	biotinylation site [posttranslational modification]; other site
393130003349	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
393130003350	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
393130003351	putative binding site residues; other site
393130003352	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
393130003353	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
393130003354	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
393130003355	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
393130003356	Walker A/P-loop; other site
393130003357	ATP binding site [chemical binding]; other site
393130003358	Q-loop/lid; other site
393130003359	ABC transporter signature motif; other site
393130003360	Walker B; other site
393130003361	D-loop; other site
393130003362	H-loop/switch region; other site
393130003363	potential frameshift: common BLAST hit: gi|289434333|ref|YP_003464205.1| N-acetylmuramoyl-L-alanine amidase family protein
393130003364	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130003365	SH3-like domain; Region: SH3_8; pfam13457
393130003366	SH3-like domain; Region: SH3_8; pfam13457
393130003367	SH3-like domain; Region: SH3_8; pfam13457
393130003368	SH3-like domain; Region: SH3_8; pfam13457
393130003369	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393130003370	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
393130003371	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
393130003372	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
393130003373	active site
393130003374	tetramer interface; other site
393130003375	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
393130003376	6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131
393130003377	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
393130003378	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393130003379	active site
393130003380	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
393130003381	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
393130003382	substrate binding site; other site
393130003383	tetramer interface; other site
393130003384	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
393130003385	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
393130003386	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
393130003387	NAD binding site [chemical binding]; other site
393130003388	substrate binding site [chemical binding]; other site
393130003389	homodimer interface [polypeptide binding]; other site
393130003390	active site
393130003391	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
393130003392	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
393130003393	NADP binding site [chemical binding]; other site
393130003394	active site
393130003395	putative substrate binding site [chemical binding]; other site
393130003396	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393130003397	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
393130003398	substrate binding site; other site
393130003399	dimer interface; other site
393130003400	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
393130003401	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393130003402	putative NAD(P) binding site [chemical binding]; other site
393130003403	putative catalytic Zn binding site [ion binding]; other site
393130003404	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
393130003405	glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171
393130003406	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
393130003407	active site
393130003408	putative glycosyl transferase; Provisional; Region: PRK10073
393130003409	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393130003410	active site
393130003411	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
393130003412	active site
393130003413	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
393130003414	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
393130003415	active site
393130003416	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
393130003417	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
393130003418	homodimer interface [polypeptide binding]; other site
393130003419	NAD binding pocket [chemical binding]; other site
393130003420	ATP binding pocket [chemical binding]; other site
393130003421	Mg binding site [ion binding]; other site
393130003422	active-site loop [active]
393130003423	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393130003424	Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440
393130003425	active site
393130003426	P-loop; other site
393130003427	phosphorylation site [posttranslational modification]
393130003428	GMP synthase; Reviewed; Region: guaA; PRK00074
393130003429	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
393130003430	AMP/PPi binding site [chemical binding]; other site
393130003431	candidate oxyanion hole; other site
393130003432	catalytic triad [active]
393130003433	potential glutamine specificity residues [chemical binding]; other site
393130003434	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
393130003435	ATP Binding subdomain [chemical binding]; other site
393130003436	Dimerization subdomain; other site
393130003437	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
393130003438	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
393130003439	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
393130003440	Int/Topo IB signature motif; other site
393130003441	LXG domain of WXG superfamily; Region: LXG; pfam04740
393130003442	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
393130003443	Domain of unknown function (DUF4274); Region: DUF4274; pfam14096
393130003444	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393130003445	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393130003446	MepB protein; Region: MepB; cl01985
393130003447	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
393130003448	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393130003449	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130003450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130003451	Coenzyme A binding pocket [chemical binding]; other site
393130003452	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130003453	Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768
393130003454	DNA binding residues [nucleotide binding]
393130003455	drug binding residues [chemical binding]; other site
393130003456	dimer interface [polypeptide binding]; other site
393130003457	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
393130003458	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130003459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130003460	Walker A/P-loop; other site
393130003461	ATP binding site [chemical binding]; other site
393130003462	Q-loop/lid; other site
393130003463	ABC transporter signature motif; other site
393130003464	Walker B; other site
393130003465	D-loop; other site
393130003466	H-loop/switch region; other site
393130003467	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130003468	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130003469	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130003470	Walker A/P-loop; other site
393130003471	ATP binding site [chemical binding]; other site
393130003472	Q-loop/lid; other site
393130003473	ABC transporter signature motif; other site
393130003474	Walker B; other site
393130003475	D-loop; other site
393130003476	H-loop/switch region; other site
393130003477	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
393130003478	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130003479	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130003480	DNA binding residues [nucleotide binding]
393130003481	putative dimer interface [polypeptide binding]; other site
393130003482	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130003483	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
393130003484	LRR adjacent; Region: LRR_adjacent; pfam08191
393130003485	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130003486	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
393130003487	Clp protease; Region: CLP_protease; pfam00574
393130003488	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
393130003489	oligomer interface [polypeptide binding]; other site
393130003490	active site residues [active]
393130003491	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393130003492	dimer interface [polypeptide binding]; other site
393130003493	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130003494	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
393130003495	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
393130003496	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
393130003497	SLBB domain; Region: SLBB; pfam10531
393130003498	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
393130003499	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
393130003500	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003501	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
393130003502	putative hexamer interface [polypeptide binding]; other site
393130003503	putative hexagonal pore; other site
393130003504	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
393130003505	putative hexamer interface [polypeptide binding]; other site
393130003506	putative hexagonal pore; other site
393130003507	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
393130003508	putative hexamer interface [polypeptide binding]; other site
393130003509	putative hexagonal pore; other site
393130003510	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
393130003511	G1 box; other site
393130003512	GTP/Mg2+ binding site [chemical binding]; other site
393130003513	G2 box; other site
393130003514	Switch I region; other site
393130003515	G3 box; other site
393130003516	Switch II region; other site
393130003517	G4 box; other site
393130003518	G5 box; other site
393130003519	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
393130003520	homotrimer interface [polypeptide binding]; other site
393130003521	Walker A motif; other site
393130003522	GTP binding site [chemical binding]; other site
393130003523	Walker B motif; other site
393130003524	Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368
393130003525	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130003526	catalytic core [active]
393130003527	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
393130003528	Sensory domain found in PocR; Region: PocR; pfam10114
393130003529	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130003530	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393130003531	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130003532	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003533	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393130003534	Hexamer interface [polypeptide binding]; other site
393130003535	Hexagonal pore residue; other site
393130003536	propanediol utilization protein PduB; Provisional; Region: PRK15415
393130003537	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
393130003538	putative hexamer interface [polypeptide binding]; other site
393130003539	putative hexagonal pore; other site
393130003540	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
393130003541	putative hexamer interface [polypeptide binding]; other site
393130003542	putative hexagonal pore; other site
393130003543	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
393130003544	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
393130003545	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
393130003546	alpha-beta subunit interface [polypeptide binding]; other site
393130003547	alpha-gamma subunit interface [polypeptide binding]; other site
393130003548	active site
393130003549	substrate and K+ binding site; other site
393130003550	K+ binding site [ion binding]; other site
393130003551	cobalamin binding site [chemical binding]; other site
393130003552	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
393130003553	Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910
393130003554	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
393130003555	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
393130003556	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003557	1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056
393130003558	putative hexamer interface [polypeptide binding]; other site
393130003559	putative hexagonal pore; other site
393130003560	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003561	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393130003562	Hexamer interface [polypeptide binding]; other site
393130003563	Hexagonal pore residue; other site
393130003564	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
393130003565	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393130003566	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393130003567	Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820
393130003568	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130003569	nucleotide binding site [chemical binding]; other site
393130003570	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
393130003571	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
393130003572	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
393130003573	Hexamer/Pentamer interface [polypeptide binding]; other site
393130003574	central pore; other site
393130003575	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
393130003576	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
393130003577	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
393130003578	putative catalytic cysteine [active]
393130003579	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
393130003580	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
393130003581	putative active site [active]
393130003582	metal binding site [ion binding]; metal-binding site
393130003583	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
393130003584	amphipathic channel; other site
393130003585	Asn-Pro-Ala signature motifs; other site
393130003586	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
393130003587	propionate/acetate kinase; Provisional; Region: PRK12379
393130003588	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
393130003589	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130003590	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130003591	homodimer interface [polypeptide binding]; other site
393130003592	catalytic residue [active]
393130003593	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
393130003594	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
393130003595	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
393130003596	putative active site [active]
393130003597	metal binding site [ion binding]; metal-binding site
393130003598	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
393130003599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130003600	active site
393130003601	phosphorylation site [posttranslational modification]
393130003602	intermolecular recognition site; other site
393130003603	dimerization interface [polypeptide binding]; other site
393130003604	ANTAR domain; Region: ANTAR; pfam03861
393130003605	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
393130003606	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
393130003607	Histidine kinase; Region: HisKA_2; pfam07568
393130003608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130003609	ATP binding site [chemical binding]; other site
393130003610	Mg2+ binding site [ion binding]; other site
393130003611	G-X-G motif; other site
393130003612	Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819
393130003613	Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303
393130003614	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
393130003615	Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302
393130003616	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
393130003617	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
393130003618	putative hexamer interface [polypeptide binding]; other site
393130003619	putative hexagonal pore; other site
393130003620	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
393130003621	putative hexamer interface [polypeptide binding]; other site
393130003622	putative hexagonal pore; other site
393130003623	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003624	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
393130003625	Hexamer interface [polypeptide binding]; other site
393130003626	Hexagonal pore residue; other site
393130003627	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
393130003628	putative catalytic cysteine [active]
393130003629	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
393130003630	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
393130003631	Hexamer interface [polypeptide binding]; other site
393130003632	Putative hexagonal pore residue; other site
393130003633	Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812
393130003634	Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869
393130003635	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393130003636	Propanediol utilisation protein PduL; Region: PduL; pfam06130
393130003637	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
393130003638	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
393130003639	Hexamer/Pentamer interface [polypeptide binding]; other site
393130003640	central pore; other site
393130003641	PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526
393130003642	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
393130003643	putative hexamer interface [polypeptide binding]; other site
393130003644	putative hexagonal pore; other site
393130003645	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
393130003646	putative hexamer interface [polypeptide binding]; other site
393130003647	putative hexagonal pore; other site
393130003648	Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346
393130003649	ethanolamine utilization protein EutQ; Provisional; Region: PRK15457
393130003650	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
393130003651	hypothetical protein; Region: PHA01818
393130003652	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130003653	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393130003654	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130003655	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
393130003656	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
393130003657	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
393130003658	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
393130003659	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
393130003660	catalytic triad [active]
393130003661	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
393130003662	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286
393130003663	Precorrin-8X methylmutase; Region: CbiC; pfam02570
393130003664	Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903
393130003665	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
393130003666	active site
393130003667	putative homodimer interface [polypeptide binding]; other site
393130003668	SAM binding site [chemical binding]; other site
393130003669	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
393130003670	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130003671	S-adenosylmethionine binding site [chemical binding]; other site
393130003672	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
393130003673	active site
393130003674	SAM binding site [chemical binding]; other site
393130003675	homodimer interface [polypeptide binding]; other site
393130003676	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
393130003677	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
393130003678	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
393130003679	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
393130003680	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
393130003681	active site
393130003682	SAM binding site [chemical binding]; other site
393130003683	homodimer interface [polypeptide binding]; other site
393130003684	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
393130003685	cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057
393130003686	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
393130003687	active site
393130003688	SAM binding site [chemical binding]; other site
393130003689	homodimer interface [polypeptide binding]; other site
393130003690	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
393130003691	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
393130003692	active site
393130003693	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
393130003694	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412
393130003695	active site
393130003696	C-terminal domain interface [polypeptide binding]; other site
393130003697	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
393130003698	active site
393130003699	N-terminal domain interface [polypeptide binding]; other site
393130003700	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
393130003701	active site
393130003702	SAM binding site [chemical binding]; other site
393130003703	homodimer interface [polypeptide binding]; other site
393130003704	cobalt transport protein CbiM; Validated; Region: PRK08319
393130003705	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
393130003706	ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930
393130003707	cobalt transport protein CbiQ; Provisional; Region: PRK15485
393130003708	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638
393130003709	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393130003710	Walker A/P-loop; other site
393130003711	ATP binding site [chemical binding]; other site
393130003712	Q-loop/lid; other site
393130003713	ABC transporter signature motif; other site
393130003714	Walker B; other site
393130003715	D-loop; other site
393130003716	H-loop/switch region; other site
393130003717	cobyric acid synthase; Provisional; Region: PRK00784
393130003718	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393130003719	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393130003720	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
393130003721	catalytic triad [active]
393130003722	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
393130003723	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
393130003724	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238
393130003725	Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563
393130003726	AAA domain; Region: AAA_17; pfam13207
393130003727	Predicted transcriptional regulators [Transcription]; Region: COG1695
393130003728	Transcriptional regulator PadR-like family; Region: PadR; cl17335
393130003729	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
393130003730	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130003731	SH3-like domain; Region: SH3_8; pfam13457
393130003732	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130003733	SH3-like domain; Region: SH3_8; pfam13457
393130003734	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393130003735	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
393130003736	oligomer interface [polypeptide binding]; other site
393130003737	active site
393130003738	metal binding site [ion binding]; metal-binding site
393130003739	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
393130003740	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
393130003741	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
393130003742	Predicted transcriptional regulators [Transcription]; Region: COG1733
393130003743	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
393130003744	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
393130003745	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
393130003746	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
393130003747	dimer interface [polypeptide binding]; other site
393130003748	motif 1; other site
393130003749	active site
393130003750	motif 2; other site
393130003751	motif 3; other site
393130003752	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
393130003753	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
393130003754	putative tRNA-binding site [nucleotide binding]; other site
393130003755	B3/4 domain; Region: B3_4; pfam03483
393130003756	tRNA synthetase B5 domain; Region: B5; smart00874
393130003757	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
393130003758	dimer interface [polypeptide binding]; other site
393130003759	motif 1; other site
393130003760	motif 3; other site
393130003761	motif 2; other site
393130003762	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
393130003763	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130003764	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130003765	Walker A/P-loop; other site
393130003766	ATP binding site [chemical binding]; other site
393130003767	Q-loop/lid; other site
393130003768	ABC transporter signature motif; other site
393130003769	Walker B; other site
393130003770	D-loop; other site
393130003771	H-loop/switch region; other site
393130003772	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130003773	FtsX-like permease family; Region: FtsX; pfam02687
393130003774	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
393130003775	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130003776	FtsX-like permease family; Region: FtsX; pfam02687
393130003777	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393130003778	MarR family; Region: MarR_2; pfam12802
393130003779	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
393130003780	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
393130003781	ligand binding site [chemical binding]; other site
393130003782	active site
393130003783	UGI interface [polypeptide binding]; other site
393130003784	catalytic site [active]
393130003785	ribonuclease HIII; Provisional; Region: PRK00996
393130003786	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
393130003787	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
393130003788	RNA/DNA hybrid binding site [nucleotide binding]; other site
393130003789	active site
393130003790	Cell division protein ZapA; Region: ZapA; cl01146
393130003791	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
393130003792	Colicin V production protein; Region: Colicin_V; pfam02674
393130003793	hypothetical protein; Provisional; Region: PRK08609
393130003794	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
393130003795	active site
393130003796	primer binding site [nucleotide binding]; other site
393130003797	NTP  binding site [chemical binding]; other site
393130003798	metal binding triad [ion binding]; metal-binding site
393130003799	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
393130003800	active site
393130003801	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
393130003802	MutS domain III; Region: MutS_III; pfam05192
393130003803	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130003804	Walker A/P-loop; other site
393130003805	ATP binding site [chemical binding]; other site
393130003806	Q-loop/lid; other site
393130003807	ABC transporter signature motif; other site
393130003808	Walker B; other site
393130003809	D-loop; other site
393130003810	H-loop/switch region; other site
393130003811	Smr domain; Region: Smr; pfam01713
393130003812	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130003813	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393130003814	catalytic residues [active]
393130003815	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
393130003816	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
393130003817	GIY-YIG motif/motif A; other site
393130003818	active site
393130003819	catalytic site [active]
393130003820	putative DNA binding site [nucleotide binding]; other site
393130003821	metal binding site [ion binding]; metal-binding site
393130003822	UvrB/uvrC motif; Region: UVR; pfam02151
393130003823	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
393130003824	aspartate kinase; Reviewed; Region: PRK06635
393130003825	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
393130003826	putative nucleotide binding site [chemical binding]; other site
393130003827	putative catalytic residues [active]
393130003828	putative Mg ion binding site [ion binding]; other site
393130003829	putative aspartate binding site [chemical binding]; other site
393130003830	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
393130003831	putative allosteric regulatory site; other site
393130003832	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
393130003833	Protein of unknown function (DUF2507); Region: DUF2507; pfam10702
393130003834	Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796
393130003835	ribonuclease PH; Reviewed; Region: rph; PRK00173
393130003836	Ribonuclease PH; Region: RNase_PH_bact; cd11362
393130003837	hexamer interface [polypeptide binding]; other site
393130003838	active site
393130003839	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
393130003840	active site
393130003841	dimerization interface [polypeptide binding]; other site
393130003842	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
393130003843	active site
393130003844	metal binding site [ion binding]; metal-binding site
393130003845	homotetramer interface [polypeptide binding]; other site
393130003846	Uncharacterized conserved protein [Function unknown]; Region: COG5361
393130003847	Protein of unknown function (DUF1254); Region: DUF1254; pfam06863
393130003848	Protein of unknown function (DUF1214); Region: DUF1214; pfam06742
393130003849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
393130003850	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
393130003851	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
393130003852	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393130003853	dimer interface [polypeptide binding]; other site
393130003854	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130003855	catalytic core [active]
393130003856	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393130003857	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
393130003858	ATP binding site [chemical binding]; other site
393130003859	Mg++ binding site [ion binding]; other site
393130003860	motif III; other site
393130003861	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130003862	nucleotide binding region [chemical binding]; other site
393130003863	ATP-binding site [chemical binding]; other site
393130003864	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
393130003865	RNA binding site [nucleotide binding]; other site
393130003866	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393130003867	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
393130003868	putative active site [active]
393130003869	nucleotide binding site [chemical binding]; other site
393130003870	nudix motif; other site
393130003871	putative metal binding site [ion binding]; other site
393130003872	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130003873	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130003874	putative substrate translocation pore; other site
393130003875	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130003876	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130003877	ligand binding site [chemical binding]; other site
393130003878	flexible hinge region; other site
393130003879	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130003880	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393130003881	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130003882	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130003883	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
393130003884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130003885	DNA-binding site [nucleotide binding]; DNA binding site
393130003886	UTRA domain; Region: UTRA; pfam07702
393130003887	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
393130003888	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
393130003889	Ca binding site [ion binding]; other site
393130003890	active site
393130003891	catalytic site [active]
393130003892	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
393130003893	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130003894	active site turn [active]
393130003895	phosphorylation site [posttranslational modification]
393130003896	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130003897	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
393130003898	nudix motif; other site
393130003899	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
393130003900	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393130003901	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
393130003902	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
393130003903	putative catalytic cysteine [active]
393130003904	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
393130003905	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
393130003906	nucleotide binding site [chemical binding]; other site
393130003907	homotetrameric interface [polypeptide binding]; other site
393130003908	putative phosphate binding site [ion binding]; other site
393130003909	putative allosteric binding site; other site
393130003910	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
393130003911	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
393130003912	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130003913	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130003914	non-specific DNA binding site [nucleotide binding]; other site
393130003915	salt bridge; other site
393130003916	sequence-specific DNA binding site [nucleotide binding]; other site
393130003917	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130003918	non-specific DNA binding site [nucleotide binding]; other site
393130003919	salt bridge; other site
393130003920	sequence-specific DNA binding site [nucleotide binding]; other site
393130003921	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
393130003922	active site
393130003923	trigger factor; Provisional; Region: tig; PRK01490
393130003924	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
393130003925	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
393130003926	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
393130003927	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
393130003928	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130003929	Walker A motif; other site
393130003930	ATP binding site [chemical binding]; other site
393130003931	Walker B motif; other site
393130003932	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393130003933	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
393130003934	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393130003935	Catalytic site [active]
393130003936	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393130003937	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
393130003938	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393130003939	Catalytic site [active]
393130003940	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
393130003941	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
393130003942	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393130003943	Catalytic site [active]
393130003944	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
393130003945	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
393130003946	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
393130003947	GTP/Mg2+ binding site [chemical binding]; other site
393130003948	G4 box; other site
393130003949	G5 box; other site
393130003950	G1 box; other site
393130003951	Switch I region; other site
393130003952	G2 box; other site
393130003953	G3 box; other site
393130003954	Switch II region; other site
393130003955	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
393130003956	RNA/DNA hybrid binding site [nucleotide binding]; other site
393130003957	active site
393130003958	DNA protecting protein DprA; Region: dprA; TIGR00732
393130003959	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
393130003960	DNA topoisomerase I; Validated; Region: PRK05582
393130003961	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
393130003962	active site
393130003963	interdomain interaction site; other site
393130003964	putative metal-binding site [ion binding]; other site
393130003965	nucleotide binding site [chemical binding]; other site
393130003966	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
393130003967	domain I; other site
393130003968	DNA binding groove [nucleotide binding]
393130003969	phosphate binding site [ion binding]; other site
393130003970	domain II; other site
393130003971	domain III; other site
393130003972	nucleotide binding site [chemical binding]; other site
393130003973	catalytic site [active]
393130003974	domain IV; other site
393130003975	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
393130003976	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
393130003977	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
393130003978	Glucose inhibited division protein A; Region: GIDA; pfam01134
393130003979	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
393130003980	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
393130003981	active site
393130003982	DNA binding site [nucleotide binding]
393130003983	Int/Topo IB signature motif; other site
393130003984	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
393130003985	active site
393130003986	HslU subunit interaction site [polypeptide binding]; other site
393130003987	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
393130003988	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130003989	Walker A motif; other site
393130003990	ATP binding site [chemical binding]; other site
393130003991	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
393130003992	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
393130003993	transcriptional repressor CodY; Validated; Region: PRK04158
393130003994	CodY GAF-like domain; Region: CodY; pfam06018
393130003995	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
393130003996	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
393130003997	active site
393130003998	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
393130003999	active site
393130004000	catalytic residues [active]
393130004001	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
393130004002	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
393130004003	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
393130004004	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130004005	Mg2+ binding site [ion binding]; other site
393130004006	G-X-G motif; other site
393130004007	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
393130004008	anchoring element; other site
393130004009	dimer interface [polypeptide binding]; other site
393130004010	ATP binding site [chemical binding]; other site
393130004011	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
393130004012	active site
393130004013	putative metal-binding site [ion binding]; other site
393130004014	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
393130004015	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
393130004016	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
393130004017	CAP-like domain; other site
393130004018	active site
393130004019	primary dimer interface [polypeptide binding]; other site
393130004020	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
393130004021	S-ribosylhomocysteinase; Provisional; Region: PRK02260
393130004022	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130004023	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130004024	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130004025	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
393130004026	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
393130004027	catalytic triad [active]
393130004028	catalytic triad [active]
393130004029	oxyanion hole [active]
393130004030	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
393130004031	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
393130004032	active site
393130004033	catalytic site [active]
393130004034	metal binding site [ion binding]; metal-binding site
393130004035	dimer interface [polypeptide binding]; other site
393130004036	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
393130004037	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
393130004038	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
393130004039	bacterial Hfq-like; Region: Hfq; cd01716
393130004040	hexamer interface [polypeptide binding]; other site
393130004041	Sm1 motif; other site
393130004042	RNA binding site [nucleotide binding]; other site
393130004043	Sm2 motif; other site
393130004044	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
393130004045	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
393130004046	HflX GTPase family; Region: HflX; cd01878
393130004047	G1 box; other site
393130004048	GTP/Mg2+ binding site [chemical binding]; other site
393130004049	Switch I region; other site
393130004050	G2 box; other site
393130004051	G3 box; other site
393130004052	Switch II region; other site
393130004053	G4 box; other site
393130004054	G5 box; other site
393130004055	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
393130004056	Aluminium resistance protein; Region: Alum_res; pfam06838
393130004057	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
393130004058	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393130004059	DNA binding residues [nucleotide binding]
393130004060	putative dimer interface [polypeptide binding]; other site
393130004061	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
393130004062	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
393130004063	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
393130004064	arsenical pump membrane protein; Provisional; Region: PRK15445
393130004065	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
393130004066	transmembrane helices; other site
393130004067	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
393130004068	LexA repressor; Validated; Region: PRK00215
393130004069	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130004070	putative DNA binding site [nucleotide binding]; other site
393130004071	putative Zn2+ binding site [ion binding]; other site
393130004072	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
393130004073	Catalytic site [active]
393130004074	cell division suppressor protein YneA; Provisional; Region: PRK14125
393130004075	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107
393130004076	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
393130004077	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393130004078	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393130004079	TPP-binding site [chemical binding]; other site
393130004080	dimer interface [polypeptide binding]; other site
393130004081	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130004082	PYR/PP interface [polypeptide binding]; other site
393130004083	dimer interface [polypeptide binding]; other site
393130004084	TPP binding site [chemical binding]; other site
393130004085	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130004086	hypothetical protein; Provisional; Region: PRK01844
393130004087	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
393130004088	Protein of unknown function (DUF970); Region: DUF970; cl17525
393130004089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393130004090	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393130004091	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130004092	S-adenosylmethionine binding site [chemical binding]; other site
393130004093	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
393130004094	ParB-like nuclease domain; Region: ParBc; pfam02195
393130004095	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
393130004096	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
393130004097	Active Sites [active]
393130004098	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
393130004099	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393130004100	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393130004101	ATP binding site [chemical binding]; other site
393130004102	putative Mg++ binding site [ion binding]; other site
393130004103	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
393130004104	putative nucleotide binding site [chemical binding]; other site
393130004105	uridine monophosphate binding site [chemical binding]; other site
393130004106	homohexameric interface [polypeptide binding]; other site
393130004107	ribosome recycling factor; Reviewed; Region: frr; PRK00083
393130004108	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
393130004109	hinge region; other site
393130004110	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
393130004111	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
393130004112	catalytic residue [active]
393130004113	putative FPP diphosphate  binding site; other site
393130004114	putative FPP binding hydrophobic cleft; other site
393130004115	dimer interface [polypeptide binding]; other site
393130004116	putative IPP diphosphate binding site; other site
393130004117	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
393130004118	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
393130004119	1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743
393130004120	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
393130004121	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
393130004122	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
393130004123	RIP metalloprotease RseP; Region: TIGR00054
393130004124	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
393130004125	active site
393130004126	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
393130004127	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
393130004128	protein binding site [polypeptide binding]; other site
393130004129	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
393130004130	putative substrate binding region [chemical binding]; other site
393130004131	prolyl-tRNA synthetase; Provisional; Region: PRK09194
393130004132	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
393130004133	dimer interface [polypeptide binding]; other site
393130004134	motif 1; other site
393130004135	active site
393130004136	motif 2; other site
393130004137	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
393130004138	putative deacylase active site [active]
393130004139	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
393130004140	active site
393130004141	motif 3; other site
393130004142	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
393130004143	anticodon binding site; other site
393130004144	DNA polymerase III PolC; Validated; Region: polC; PRK00448
393130004145	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
393130004146	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
393130004147	generic binding surface II; other site
393130004148	generic binding surface I; other site
393130004149	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
393130004150	active site
393130004151	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
393130004152	active site
393130004153	catalytic site [active]
393130004154	substrate binding site [chemical binding]; other site
393130004155	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
393130004156	ribosome maturation protein RimP; Reviewed; Region: PRK00092
393130004157	Sm and related proteins; Region: Sm_like; cl00259
393130004158	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
393130004159	putative oligomer interface [polypeptide binding]; other site
393130004160	putative RNA binding site [nucleotide binding]; other site
393130004161	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
393130004162	NusA N-terminal domain; Region: NusA_N; pfam08529
393130004163	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
393130004164	RNA binding site [nucleotide binding]; other site
393130004165	homodimer interface [polypeptide binding]; other site
393130004166	NusA-like KH domain; Region: KH_5; pfam13184
393130004167	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
393130004168	G-X-X-G motif; other site
393130004169	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
393130004170	putative RNA binding cleft [nucleotide binding]; other site
393130004171	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
393130004172	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
393130004173	translation initiation factor IF-2; Region: IF-2; TIGR00487
393130004174	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
393130004175	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
393130004176	G1 box; other site
393130004177	putative GEF interaction site [polypeptide binding]; other site
393130004178	GTP/Mg2+ binding site [chemical binding]; other site
393130004179	Switch I region; other site
393130004180	G2 box; other site
393130004181	G3 box; other site
393130004182	Switch II region; other site
393130004183	G4 box; other site
393130004184	G5 box; other site
393130004185	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
393130004186	Translation-initiation factor 2; Region: IF-2; pfam11987
393130004187	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
393130004188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550
393130004189	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
393130004190	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
393130004191	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
393130004192	RNA binding site [nucleotide binding]; other site
393130004193	active site
393130004194	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
393130004195	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
393130004196	active site
393130004197	Riboflavin kinase; Region: Flavokinase; smart00904
393130004198	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
393130004199	16S/18S rRNA binding site [nucleotide binding]; other site
393130004200	S13e-L30e interaction site [polypeptide binding]; other site
393130004201	25S rRNA binding site [nucleotide binding]; other site
393130004202	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
393130004203	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
393130004204	RNase E interface [polypeptide binding]; other site
393130004205	trimer interface [polypeptide binding]; other site
393130004206	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
393130004207	RNase E interface [polypeptide binding]; other site
393130004208	trimer interface [polypeptide binding]; other site
393130004209	active site
393130004210	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
393130004211	putative nucleic acid binding region [nucleotide binding]; other site
393130004212	G-X-X-G motif; other site
393130004213	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
393130004214	RNA binding site [nucleotide binding]; other site
393130004215	domain interface; other site
393130004216	GTPase RsgA; Reviewed; Region: PRK01889
393130004217	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
393130004218	RNA binding site [nucleotide binding]; other site
393130004219	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
393130004220	GTPase/Zn-binding domain interface [polypeptide binding]; other site
393130004221	GTP/Mg2+ binding site [chemical binding]; other site
393130004222	G4 box; other site
393130004223	G5 box; other site
393130004224	G1 box; other site
393130004225	Switch I region; other site
393130004226	G2 box; other site
393130004227	G3 box; other site
393130004228	Switch II region; other site
393130004229	YceG-like family; Region: YceG; pfam02618
393130004230	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
393130004231	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
393130004232	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
393130004233	Rhomboid family; Region: Rhomboid; pfam01694
393130004234	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130004235	TPR motif; other site
393130004236	TPR repeat; Region: TPR_11; pfam13414
393130004237	binding surface
393130004238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483
393130004239	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
393130004240	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130004241	nucleotide binding site [chemical binding]; other site
393130004242	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
393130004243	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
393130004244	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
393130004245	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
393130004246	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
393130004247	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
393130004248	Type II/IV secretion system protein; Region: T2SE; pfam00437
393130004249	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393130004250	Walker A motif; other site
393130004251	ATP binding site [chemical binding]; other site
393130004252	Walker B motif; other site
393130004253	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
393130004254	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
393130004255	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
393130004256	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
393130004257	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
393130004258	tetramer interface [polypeptide binding]; other site
393130004259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130004260	catalytic residue [active]
393130004261	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
393130004262	tetramer interface [polypeptide binding]; other site
393130004263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130004264	catalytic residue [active]
393130004265	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
393130004266	active site residue [active]
393130004267	Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872
393130004268	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
393130004269	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
393130004270	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
393130004271	active site
393130004272	elongation factor P; Validated; Region: PRK00529
393130004273	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
393130004274	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
393130004275	RNA binding site [nucleotide binding]; other site
393130004276	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
393130004277	RNA binding site [nucleotide binding]; other site
393130004278	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
393130004279	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
393130004280	carboxyltransferase (CT) interaction site; other site
393130004281	biotinylation site [posttranslational modification]; other site
393130004282	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
393130004283	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393130004284	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393130004285	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
393130004286	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
393130004287	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
393130004288	putative RNA binding site [nucleotide binding]; other site
393130004289	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170
393130004290	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
393130004291	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
393130004292	homodimer interface [polypeptide binding]; other site
393130004293	NADP binding site [chemical binding]; other site
393130004294	substrate binding site [chemical binding]; other site
393130004295	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
393130004296	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
393130004297	generic binding surface II; other site
393130004298	generic binding surface I; other site
393130004299	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064
393130004300	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393130004301	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393130004302	substrate binding pocket [chemical binding]; other site
393130004303	chain length determination region; other site
393130004304	substrate-Mg2+ binding site; other site
393130004305	catalytic residues [active]
393130004306	aspartate-rich region 1; other site
393130004307	active site lid residues [active]
393130004308	aspartate-rich region 2; other site
393130004309	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393130004310	DNA-binding site [nucleotide binding]; DNA binding site
393130004311	RNA-binding motif; other site
393130004312	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
393130004313	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
393130004314	TPP-binding site; other site
393130004315	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130004316	PYR/PP interface [polypeptide binding]; other site
393130004317	dimer interface [polypeptide binding]; other site
393130004318	TPP binding site [chemical binding]; other site
393130004319	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130004320	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
393130004321	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130004322	RNA binding surface [nucleotide binding]; other site
393130004323	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
393130004324	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
393130004325	arginine repressor; Provisional; Region: PRK04280
393130004326	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
393130004327	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
393130004328	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
393130004329	Walker A/P-loop; other site
393130004330	ATP binding site [chemical binding]; other site
393130004331	Q-loop/lid; other site
393130004332	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
393130004333	ABC transporter signature motif; other site
393130004334	Walker B; other site
393130004335	D-loop; other site
393130004336	H-loop/switch region; other site
393130004337	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
393130004338	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130004339	nucleotide binding site [chemical binding]; other site
393130004340	Acetokinase family; Region: Acetate_kinase; cl17229
393130004341	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
393130004342	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130004343	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393130004344	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
393130004345	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
393130004346	tetramer interface [polypeptide binding]; other site
393130004347	TPP-binding site [chemical binding]; other site
393130004348	heterodimer interface [polypeptide binding]; other site
393130004349	phosphorylation loop region [posttranslational modification]
393130004350	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
393130004351	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
393130004352	alpha subunit interface [polypeptide binding]; other site
393130004353	TPP binding site [chemical binding]; other site
393130004354	heterodimer interface [polypeptide binding]; other site
393130004355	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
393130004356	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
393130004357	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
393130004358	E3 interaction surface; other site
393130004359	lipoyl attachment site [posttranslational modification]; other site
393130004360	e3 binding domain; Region: E3_binding; pfam02817
393130004361	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
393130004362	peptidase T-like protein; Region: PepT-like; TIGR01883
393130004363	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
393130004364	metal binding site [ion binding]; metal-binding site
393130004365	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
393130004366	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
393130004367	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
393130004368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130004369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130004370	active site
393130004371	phosphorylation site [posttranslational modification]
393130004372	intermolecular recognition site; other site
393130004373	dimerization interface [polypeptide binding]; other site
393130004374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130004375	DNA binding site [nucleotide binding]
393130004376	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393130004377	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130004378	dimerization interface [polypeptide binding]; other site
393130004379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130004380	dimer interface [polypeptide binding]; other site
393130004381	phosphorylation site [posttranslational modification]
393130004382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130004383	ATP binding site [chemical binding]; other site
393130004384	Mg2+ binding site [ion binding]; other site
393130004385	G-X-G motif; other site
393130004386	OxaA-like protein precursor; Validated; Region: PRK01622
393130004387	acylphosphatase; Provisional; Region: PRK14443
393130004388	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
393130004389	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
393130004390	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
393130004391	homotetramer interface [polypeptide binding]; other site
393130004392	FMN binding site [chemical binding]; other site
393130004393	homodimer contacts [polypeptide binding]; other site
393130004394	putative active site [active]
393130004395	putative substrate binding site [chemical binding]; other site
393130004396	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
393130004397	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
393130004398	active site residue [active]
393130004399	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
393130004400	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393130004401	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130004402	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130004403	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
393130004404	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
393130004405	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393130004406	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
393130004407	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928
393130004408	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
393130004409	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
393130004410	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
393130004411	ligand binding site [chemical binding]; other site
393130004412	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
393130004413	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
393130004414	Walker A/P-loop; other site
393130004415	ATP binding site [chemical binding]; other site
393130004416	Q-loop/lid; other site
393130004417	ABC transporter signature motif; other site
393130004418	Walker B; other site
393130004419	D-loop; other site
393130004420	H-loop/switch region; other site
393130004421	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
393130004422	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
393130004423	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
393130004424	TM-ABC transporter signature motif; other site
393130004425	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
393130004426	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
393130004427	TM-ABC transporter signature motif; other site
393130004428	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
393130004429	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
393130004430	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
393130004431	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
393130004432	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
393130004433	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
393130004434	classical (c) SDRs; Region: SDR_c; cd05233
393130004435	NAD(P) binding site [chemical binding]; other site
393130004436	active site
393130004437	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
393130004438	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130004439	non-specific DNA binding site [nucleotide binding]; other site
393130004440	salt bridge; other site
393130004441	sequence-specific DNA binding site [nucleotide binding]; other site
393130004442	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
393130004443	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
393130004444	competence damage-inducible protein A; Provisional; Region: PRK00549
393130004445	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
393130004446	putative MPT binding site; other site
393130004447	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
393130004448	recombinase A; Provisional; Region: recA; PRK09354
393130004449	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
393130004450	hexamer interface [polypeptide binding]; other site
393130004451	Walker A motif; other site
393130004452	ATP binding site [chemical binding]; other site
393130004453	Walker B motif; other site
393130004454	phosphodiesterase; Provisional; Region: PRK12704
393130004455	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130004456	Zn2+ binding site [ion binding]; other site
393130004457	Mg2+ binding site [ion binding]; other site
393130004458	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
393130004459	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130004460	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393130004461	Coenzyme A binding pocket [chemical binding]; other site
393130004462	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
393130004463	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393130004464	putative active site [active]
393130004465	metal binding site [ion binding]; metal-binding site
393130004466	homodimer binding site [polypeptide binding]; other site
393130004467	Predicted membrane protein [Function unknown]; Region: COG4550
393130004468	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
393130004469	MutS domain I; Region: MutS_I; pfam01624
393130004470	MutS domain II; Region: MutS_II; pfam05188
393130004471	MutS domain III; Region: MutS_III; pfam05192
393130004472	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
393130004473	Walker A/P-loop; other site
393130004474	ATP binding site [chemical binding]; other site
393130004475	Q-loop/lid; other site
393130004476	ABC transporter signature motif; other site
393130004477	Walker B; other site
393130004478	D-loop; other site
393130004479	H-loop/switch region; other site
393130004480	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
393130004481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130004482	ATP binding site [chemical binding]; other site
393130004483	Mg2+ binding site [ion binding]; other site
393130004484	G-X-G motif; other site
393130004485	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
393130004486	ATP binding site [chemical binding]; other site
393130004487	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
393130004488	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
393130004489	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
393130004490	Pyruvate formate lyase 1; Region: PFL1; cd01678
393130004491	coenzyme A binding site [chemical binding]; other site
393130004492	active site
393130004493	catalytic residues [active]
393130004494	glycine loop; other site
393130004495	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
393130004496	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393130004497	FeS/SAM binding site; other site
393130004498	Predicted transcriptional regulators [Transcription]; Region: COG1695
393130004499	Transcriptional regulator PadR-like family; Region: PadR; cl17335
393130004500	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130004501	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130004502	putative substrate translocation pore; other site
393130004503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130004504	non-specific DNA binding site [nucleotide binding]; other site
393130004505	salt bridge; other site
393130004506	sequence-specific DNA binding site [nucleotide binding]; other site
393130004507	topology modulation protein; Provisional; Region: PRK07261
393130004508	AAA domain; Region: AAA_17; pfam13207
393130004509	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130004510	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130004511	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130004512	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130004513	putative acyltransferase; Provisional; Region: PRK05790
393130004514	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
393130004515	dimer interface [polypeptide binding]; other site
393130004516	active site
393130004517	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
393130004518	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
393130004519	dimer interface [polypeptide binding]; other site
393130004520	active site
393130004521	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
393130004522	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
393130004523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130004524	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
393130004525	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
393130004526	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
393130004527	Domain of unknown function DUF20; Region: UPF0118; pfam01594
393130004528	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
393130004529	FAD binding domain; Region: FAD_binding_4; pfam01565
393130004530	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
393130004531	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
393130004532	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
393130004533	Walker A/P-loop; other site
393130004534	ATP binding site [chemical binding]; other site
393130004535	Q-loop/lid; other site
393130004536	ABC transporter signature motif; other site
393130004537	Walker B; other site
393130004538	D-loop; other site
393130004539	H-loop/switch region; other site
393130004540	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393130004541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130004542	dimer interface [polypeptide binding]; other site
393130004543	conserved gate region; other site
393130004544	ABC-ATPase subunit interface; other site
393130004545	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
393130004546	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
393130004547	manganese transport protein MntH; Reviewed; Region: PRK00701
393130004548	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
393130004549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130004550	dimer interface [polypeptide binding]; other site
393130004551	conserved gate region; other site
393130004552	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
393130004553	ABC-ATPase subunit interface; other site
393130004554	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
393130004555	LysR substrate binding domain; Region: LysR_substrate; pfam03466
393130004556	dimerization interface [polypeptide binding]; other site
393130004557	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130004558	dimer interface [polypeptide binding]; other site
393130004559	conserved gate region; other site
393130004560	putative PBP binding loops; other site
393130004561	ABC-ATPase subunit interface; other site
393130004562	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
393130004563	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
393130004564	Walker A/P-loop; other site
393130004565	ATP binding site [chemical binding]; other site
393130004566	Q-loop/lid; other site
393130004567	ABC transporter signature motif; other site
393130004568	Walker B; other site
393130004569	D-loop; other site
393130004570	H-loop/switch region; other site
393130004571	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
393130004572	Predicted membrane protein [Function unknown]; Region: COG3859
393130004573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
393130004574	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
393130004575	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130004576	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130004577	ABC transporter; Region: ABC_tran_2; pfam12848
393130004578	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130004579	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
393130004580	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130004581	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130004582	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
393130004583	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
393130004584	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130004585	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
393130004586	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
393130004587	dihydrodipicolinate synthase; Region: dapA; TIGR00674
393130004588	dimer interface [polypeptide binding]; other site
393130004589	active site
393130004590	catalytic residue [active]
393130004591	aspartate kinase I; Reviewed; Region: PRK08210
393130004592	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
393130004593	nucleotide binding site [chemical binding]; other site
393130004594	substrate binding site [chemical binding]; other site
393130004595	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
393130004596	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
393130004597	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
393130004598	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
393130004599	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
393130004600	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393130004601	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393130004602	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
393130004603	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
393130004604	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
393130004605	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
393130004606	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
393130004607	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
393130004608	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
393130004609	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
393130004610	Predicted membrane protein [Function unknown]; Region: COG4392
393130004611	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
393130004612	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
393130004613	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393130004614	metal binding site 2 [ion binding]; metal-binding site
393130004615	putative DNA binding helix; other site
393130004616	metal binding site 1 [ion binding]; metal-binding site
393130004617	dimer interface [polypeptide binding]; other site
393130004618	structural Zn2+ binding site [ion binding]; other site
393130004619	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393130004620	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130004621	ABC-ATPase subunit  interface; other site
393130004622	dimer interface [polypeptide binding]; other site
393130004623	putative PBP binding regions; other site
393130004624	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
393130004625	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393130004626	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
393130004627	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
393130004628	DHHA2 domain; Region: DHHA2; pfam02833
393130004629	endonuclease IV; Provisional; Region: PRK01060
393130004630	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
393130004631	AP (apurinic/apyrimidinic) site pocket; other site
393130004632	DNA interaction; other site
393130004633	Metal-binding active site; metal-binding site
393130004634	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
393130004635	DEAD-like helicases superfamily; Region: DEXDc; smart00487
393130004636	ATP binding site [chemical binding]; other site
393130004637	Mg++ binding site [ion binding]; other site
393130004638	motif III; other site
393130004639	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130004640	nucleotide binding region [chemical binding]; other site
393130004641	ATP-binding site [chemical binding]; other site
393130004642	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
393130004643	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
393130004644	Uncharacterized conserved protein [Function unknown]; Region: COG0327
393130004645	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
393130004646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
393130004647	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
393130004648	Uncharacterized conserved protein [Function unknown]; Region: COG0327
393130004649	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
393130004650	Family of unknown function (DUF633); Region: DUF633; pfam04816
393130004651	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
393130004652	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
393130004653	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
393130004654	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
393130004655	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
393130004656	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
393130004657	DNA binding residues [nucleotide binding]
393130004658	DNA primase; Validated; Region: dnaG; PRK05667
393130004659	CHC2 zinc finger; Region: zf-CHC2; pfam01807
393130004660	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
393130004661	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
393130004662	active site
393130004663	metal binding site [ion binding]; metal-binding site
393130004664	interdomain interaction site; other site
393130004665	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
393130004666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671
393130004667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806
393130004668	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
393130004669	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
393130004670	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
393130004671	dimer interface [polypeptide binding]; other site
393130004672	motif 1; other site
393130004673	active site
393130004674	motif 2; other site
393130004675	motif 3; other site
393130004676	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
393130004677	Recombination protein O N terminal; Region: RecO_N; pfam11967
393130004678	Recombination protein O C terminal; Region: RecO_C; pfam02565
393130004679	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
393130004680	GTPase Era; Reviewed; Region: era; PRK00089
393130004681	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
393130004682	G1 box; other site
393130004683	GTP/Mg2+ binding site [chemical binding]; other site
393130004684	Switch I region; other site
393130004685	G2 box; other site
393130004686	Switch II region; other site
393130004687	G3 box; other site
393130004688	G4 box; other site
393130004689	G5 box; other site
393130004690	KH domain; Region: KH_2; pfam07650
393130004691	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
393130004692	active site
393130004693	catalytic motif [active]
393130004694	Zn binding site [ion binding]; other site
393130004695	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
393130004696	metal-binding heat shock protein; Provisional; Region: PRK00016
393130004697	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
393130004698	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
393130004699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130004700	Zn2+ binding site [ion binding]; other site
393130004701	Mg2+ binding site [ion binding]; other site
393130004702	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
393130004703	PhoH-like protein; Region: PhoH; pfam02562
393130004704	Yqey-like protein; Region: YqeY; pfam09424
393130004705	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
393130004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
393130004707	RNA methyltransferase, RsmE family; Region: TIGR00046
393130004708	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
393130004709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130004710	S-adenosylmethionine binding site [chemical binding]; other site
393130004711	chaperone protein DnaJ; Provisional; Region: PRK14280
393130004712	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
393130004713	HSP70 interaction site [polypeptide binding]; other site
393130004714	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
393130004715	substrate binding site [polypeptide binding]; other site
393130004716	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
393130004717	Zn binding sites [ion binding]; other site
393130004718	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
393130004719	dimer interface [polypeptide binding]; other site
393130004720	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
393130004721	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
393130004722	nucleotide binding site [chemical binding]; other site
393130004723	NEF interaction site [polypeptide binding]; other site
393130004724	SBD interface [polypeptide binding]; other site
393130004725	heat shock protein GrpE; Provisional; Region: PRK14140
393130004726	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
393130004727	dimer interface [polypeptide binding]; other site
393130004728	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
393130004729	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
393130004730	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
393130004731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393130004732	FeS/SAM binding site; other site
393130004733	HemN C-terminal domain; Region: HemN_C; pfam06969
393130004734	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
393130004735	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
393130004736	NADP binding site [chemical binding]; other site
393130004737	putative substrate binding site [chemical binding]; other site
393130004738	active site
393130004739	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130004740	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130004741	DNA binding residues [nucleotide binding]
393130004742	putative dimer interface [polypeptide binding]; other site
393130004743	GTP-binding protein LepA; Provisional; Region: PRK05433
393130004744	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
393130004745	G1 box; other site
393130004746	putative GEF interaction site [polypeptide binding]; other site
393130004747	GTP/Mg2+ binding site [chemical binding]; other site
393130004748	Switch I region; other site
393130004749	G2 box; other site
393130004750	G3 box; other site
393130004751	Switch II region; other site
393130004752	G4 box; other site
393130004753	G5 box; other site
393130004754	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
393130004755	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
393130004756	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
393130004757	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
393130004758	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
393130004759	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
393130004760	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
393130004761	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
393130004762	Competence protein; Region: Competence; pfam03772
393130004763	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130004764	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
393130004765	catalytic motif [active]
393130004766	Zn binding site [ion binding]; other site
393130004767	SLBB domain; Region: SLBB; pfam10531
393130004768	comEA protein; Region: comE; TIGR01259
393130004769	Helix-hairpin-helix motif; Region: HHH; pfam00633
393130004770	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393130004771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130004772	S-adenosylmethionine binding site [chemical binding]; other site
393130004773	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
393130004774	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130004775	Zn2+ binding site [ion binding]; other site
393130004776	Mg2+ binding site [ion binding]; other site
393130004777	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
393130004778	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
393130004779	active site
393130004780	(T/H)XGH motif; other site
393130004781	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
393130004782	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
393130004783	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393130004784	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393130004785	shikimate binding site; other site
393130004786	NAD(P) binding site [chemical binding]; other site
393130004787	GTPase YqeH; Provisional; Region: PRK13796
393130004788	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
393130004789	GTP/Mg2+ binding site [chemical binding]; other site
393130004790	G4 box; other site
393130004791	G5 box; other site
393130004792	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
393130004793	G1 box; other site
393130004794	G1 box; other site
393130004795	GTP/Mg2+ binding site [chemical binding]; other site
393130004796	G2 box; other site
393130004797	Switch I region; other site
393130004798	G2 box; other site
393130004799	Switch I region; other site
393130004800	G3 box; other site
393130004801	G3 box; other site
393130004802	Switch II region; other site
393130004803	Switch II region; other site
393130004804	G4 box; other site
393130004805	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
393130004806	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130004807	motif II; other site
393130004808	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
393130004809	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
393130004810	active site
393130004811	Zn binding site [ion binding]; other site
393130004812	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
393130004813	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
393130004814	Protein of unknown function (DUF1510); Region: DUF1510; pfam07423
393130004815	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
393130004816	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
393130004817	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
393130004818	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
393130004819	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
393130004820	Sugar specificity; other site
393130004821	Pyrimidine base specificity; other site
393130004822	ATP-binding site [chemical binding]; other site
393130004823	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
393130004824	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130004825	S-adenosylmethionine binding site [chemical binding]; other site
393130004826	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
393130004827	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
393130004828	dimerization interface [polypeptide binding]; other site
393130004829	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393130004830	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393130004831	hypothetical protein; Provisional; Region: PRK13678
393130004832	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
393130004833	hypothetical protein; Provisional; Region: PRK05473
393130004834	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
393130004835	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
393130004836	motif 1; other site
393130004837	active site
393130004838	motif 2; other site
393130004839	motif 3; other site
393130004840	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
393130004841	DHHA1 domain; Region: DHHA1; pfam02272
393130004842	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130004843	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130004844	Walker A/P-loop; other site
393130004845	ATP binding site [chemical binding]; other site
393130004846	Q-loop/lid; other site
393130004847	ABC transporter signature motif; other site
393130004848	Walker B; other site
393130004849	D-loop; other site
393130004850	H-loop/switch region; other site
393130004851	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130004852	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393130004853	FtsX-like permease family; Region: FtsX; pfam02687
393130004854	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130004855	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130004856	active site
393130004857	phosphorylation site [posttranslational modification]
393130004858	intermolecular recognition site; other site
393130004859	dimerization interface [polypeptide binding]; other site
393130004860	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130004861	DNA binding site [nucleotide binding]
393130004862	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
393130004863	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130004864	dimerization interface [polypeptide binding]; other site
393130004865	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130004866	dimer interface [polypeptide binding]; other site
393130004867	phosphorylation site [posttranslational modification]
393130004868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130004869	ATP binding site [chemical binding]; other site
393130004870	Mg2+ binding site [ion binding]; other site
393130004871	G-X-G motif; other site
393130004872	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
393130004873	AAA domain; Region: AAA_30; pfam13604
393130004874	Family description; Region: UvrD_C_2; pfam13538
393130004875	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130004876	binding surface
393130004877	TPR motif; other site
393130004878	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
393130004879	TPR repeat; Region: TPR_11; pfam13414
393130004880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130004881	binding surface
393130004882	TPR motif; other site
393130004883	TPR repeat; Region: TPR_11; pfam13414
393130004884	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
393130004885	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
393130004886	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
393130004887	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393130004888	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393130004889	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130004890	catalytic residue [active]
393130004891	ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256
393130004892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130004893	Walker A motif; other site
393130004894	ATP binding site [chemical binding]; other site
393130004895	Walker B motif; other site
393130004896	arginine finger; other site
393130004897	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
393130004898	Predicted transcriptional regulator [Transcription]; Region: COG1959
393130004899	Transcriptional regulator; Region: Rrf2; pfam02082
393130004900	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
393130004901	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
393130004902	Nitrogen regulatory protein P-II; Region: P-II; smart00938
393130004903	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
393130004904	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
393130004905	dimer interface [polypeptide binding]; other site
393130004906	anticodon binding site; other site
393130004907	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
393130004908	homodimer interface [polypeptide binding]; other site
393130004909	motif 1; other site
393130004910	active site
393130004911	motif 2; other site
393130004912	GAD domain; Region: GAD; pfam02938
393130004913	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
393130004914	active site
393130004915	motif 3; other site
393130004916	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
393130004917	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
393130004918	dimer interface [polypeptide binding]; other site
393130004919	motif 1; other site
393130004920	active site
393130004921	motif 2; other site
393130004922	motif 3; other site
393130004923	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
393130004924	anticodon binding site; other site
393130004925	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
393130004926	Bacterial SH3 domain; Region: SH3_3; pfam08239
393130004927	Bacterial SH3 domain; Region: SH3_3; pfam08239
393130004928	Bacterial SH3 domain homologues; Region: SH3b; smart00287
393130004929	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
393130004930	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
393130004931	active site
393130004932	metal binding site [ion binding]; metal-binding site
393130004933	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
393130004934	putative active site [active]
393130004935	dimerization interface [polypeptide binding]; other site
393130004936	putative tRNAtyr binding site [nucleotide binding]; other site
393130004937	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
393130004938	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130004939	Zn2+ binding site [ion binding]; other site
393130004940	Mg2+ binding site [ion binding]; other site
393130004941	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
393130004942	synthetase active site [active]
393130004943	NTP binding site [chemical binding]; other site
393130004944	metal binding site [ion binding]; metal-binding site
393130004945	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
393130004946	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
393130004947	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130004948	active site
393130004949	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
393130004950	DHH family; Region: DHH; pfam01368
393130004951	DHHA1 domain; Region: DHHA1; pfam02272
393130004952	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
393130004953	Uncharacterized integral membrane protein [Function unknown]; Region: COG5416
393130004954	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
393130004955	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
393130004956	Protein export membrane protein; Region: SecD_SecF; cl14618
393130004957	Protein export membrane protein; Region: SecD_SecF; pfam02355
393130004958	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
393130004959	Preprotein translocase subunit; Region: YajC; pfam02699
393130004960	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
393130004961	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
393130004962	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
393130004963	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
393130004964	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
393130004965	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130004966	Walker A motif; other site
393130004967	ATP binding site [chemical binding]; other site
393130004968	Walker B motif; other site
393130004969	arginine finger; other site
393130004970	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
393130004971	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
393130004972	RuvA N terminal domain; Region: RuvA_N; pfam01330
393130004973	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
393130004974	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393130004975	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130004976	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
393130004977	NAD binding site [chemical binding]; other site
393130004978	dimer interface [polypeptide binding]; other site
393130004979	substrate binding site [chemical binding]; other site
393130004980	hypothetical protein; Validated; Region: PRK00110
393130004981	prephenate dehydratase; Provisional; Region: PRK11898
393130004982	Prephenate dehydratase; Region: PDT; pfam00800
393130004983	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
393130004984	putative L-Phe binding site [chemical binding]; other site
393130004985	GTPase CgtA; Reviewed; Region: obgE; PRK12297
393130004986	GTP1/OBG; Region: GTP1_OBG; pfam01018
393130004987	Obg GTPase; Region: Obg; cd01898
393130004988	G1 box; other site
393130004989	GTP/Mg2+ binding site [chemical binding]; other site
393130004990	Switch I region; other site
393130004991	G2 box; other site
393130004992	G3 box; other site
393130004993	Switch II region; other site
393130004994	G4 box; other site
393130004995	G5 box; other site
393130004996	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
393130004997	glycerol kinase; Provisional; Region: glpK; PRK00047
393130004998	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
393130004999	N- and C-terminal domain interface [polypeptide binding]; other site
393130005000	active site
393130005001	MgATP binding site [chemical binding]; other site
393130005002	catalytic site [active]
393130005003	metal binding site [ion binding]; metal-binding site
393130005004	glycerol binding site [chemical binding]; other site
393130005005	homotetramer interface [polypeptide binding]; other site
393130005006	homodimer interface [polypeptide binding]; other site
393130005007	FBP binding site [chemical binding]; other site
393130005008	protein IIAGlc interface [polypeptide binding]; other site
393130005009	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
393130005010	amphipathic channel; other site
393130005011	Asn-Pro-Ala signature motifs; other site
393130005012	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
393130005013	hypothetical protein; Provisional; Region: PRK14553
393130005014	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
393130005015	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
393130005016	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
393130005017	homodimer interface [polypeptide binding]; other site
393130005018	oligonucleotide binding site [chemical binding]; other site
393130005019	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
393130005020	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
393130005021	Switch I; other site
393130005022	Switch II; other site
393130005023	septum formation inhibitor; Reviewed; Region: minC; PRK00513
393130005024	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
393130005025	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
393130005026	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
393130005027	Protein of unknown function (DUF972); Region: DUF972; pfam06156
393130005028	rod shape-determining protein MreC; Region: MreC; pfam04085
393130005029	rod shape-determining protein MreB; Provisional; Region: PRK13927
393130005030	MreB and similar proteins; Region: MreB_like; cd10225
393130005031	nucleotide binding site [chemical binding]; other site
393130005032	Mg binding site [ion binding]; other site
393130005033	putative protofilament interaction site [polypeptide binding]; other site
393130005034	RodZ interaction site [polypeptide binding]; other site
393130005035	hypothetical protein; Reviewed; Region: PRK00024
393130005036	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
393130005037	MPN+ (JAMM) motif; other site
393130005038	Zinc-binding site [ion binding]; other site
393130005039	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
393130005040	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
393130005041	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
393130005042	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393130005043	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393130005044	AAA domain; Region: AAA_14; pfam13173
393130005045	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
393130005046	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
393130005047	active site
393130005048	HIGH motif; other site
393130005049	nucleotide binding site [chemical binding]; other site
393130005050	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
393130005051	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
393130005052	active site
393130005053	KMSKS motif; other site
393130005054	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
393130005055	tRNA binding surface [nucleotide binding]; other site
393130005056	anticodon binding site; other site
393130005057	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
393130005058	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
393130005059	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393130005060	inhibitor-cofactor binding pocket; inhibition site
393130005061	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005062	catalytic residue [active]
393130005063	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
393130005064	dimer interface [polypeptide binding]; other site
393130005065	active site
393130005066	Schiff base residues; other site
393130005067	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
393130005068	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
393130005069	active site
393130005070	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
393130005071	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
393130005072	domain interfaces; other site
393130005073	active site
393130005074	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
393130005075	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
393130005076	tRNA; other site
393130005077	putative tRNA binding site [nucleotide binding]; other site
393130005078	putative NADP binding site [chemical binding]; other site
393130005079	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
393130005080	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
393130005081	G1 box; other site
393130005082	GTP/Mg2+ binding site [chemical binding]; other site
393130005083	Switch I region; other site
393130005084	G2 box; other site
393130005085	G3 box; other site
393130005086	Switch II region; other site
393130005087	G4 box; other site
393130005088	G5 box; other site
393130005089	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
393130005090	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
393130005091	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
393130005092	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
393130005093	active site
393130005094	dimer interface [polypeptide binding]; other site
393130005095	motif 1; other site
393130005096	motif 2; other site
393130005097	motif 3; other site
393130005098	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
393130005099	anticodon binding site; other site
393130005100	primosomal protein DnaI; Reviewed; Region: PRK08939
393130005101	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
393130005102	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
393130005103	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
393130005104	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
393130005105	ATP cone domain; Region: ATP-cone; pfam03477
393130005106	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
393130005107	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
393130005108	CoA-binding site [chemical binding]; other site
393130005109	ATP-binding [chemical binding]; other site
393130005110	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
393130005111	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
393130005112	DNA binding site [nucleotide binding]
393130005113	catalytic residue [active]
393130005114	H2TH interface [polypeptide binding]; other site
393130005115	putative catalytic residues [active]
393130005116	turnover-facilitating residue; other site
393130005117	intercalation triad [nucleotide binding]; other site
393130005118	8OG recognition residue [nucleotide binding]; other site
393130005119	putative reading head residues; other site
393130005120	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
393130005121	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
393130005122	DNA polymerase I; Provisional; Region: PRK05755
393130005123	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
393130005124	active site
393130005125	metal binding site 1 [ion binding]; metal-binding site
393130005126	putative 5' ssDNA interaction site; other site
393130005127	metal binding site 3; metal-binding site
393130005128	metal binding site 2 [ion binding]; metal-binding site
393130005129	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
393130005130	putative DNA binding site [nucleotide binding]; other site
393130005131	putative metal binding site [ion binding]; other site
393130005132	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
393130005133	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
393130005134	active site
393130005135	DNA binding site [nucleotide binding]
393130005136	catalytic site [active]
393130005137	isocitrate dehydrogenase; Reviewed; Region: PRK07006
393130005138	isocitrate dehydrogenase; Validated; Region: PRK07362
393130005139	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
393130005140	dimer interface [polypeptide binding]; other site
393130005141	Citrate synthase; Region: Citrate_synt; pfam00285
393130005142	active site
393130005143	citrylCoA binding site [chemical binding]; other site
393130005144	oxalacetate/citrate binding site [chemical binding]; other site
393130005145	coenzyme A binding site [chemical binding]; other site
393130005146	catalytic triad [active]
393130005147	Protein of unknown function (DUF441); Region: DUF441; pfam04284
393130005148	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
393130005149	pyruvate kinase; Provisional; Region: PRK06354
393130005150	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
393130005151	domain interfaces; other site
393130005152	active site
393130005153	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
393130005154	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
393130005155	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
393130005156	active site
393130005157	ADP/pyrophosphate binding site [chemical binding]; other site
393130005158	dimerization interface [polypeptide binding]; other site
393130005159	allosteric effector site; other site
393130005160	fructose-1,6-bisphosphate binding site; other site
393130005161	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
393130005162	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
393130005163	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
393130005164	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
393130005165	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
393130005166	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
393130005167	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
393130005168	active site
393130005169	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
393130005170	generic binding surface I; other site
393130005171	generic binding surface II; other site
393130005172	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
393130005173	DHH family; Region: DHH; pfam01368
393130005174	DHHA1 domain; Region: DHHA1; pfam02272
393130005175	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
393130005176	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
393130005177	DNA-binding site [nucleotide binding]; DNA binding site
393130005178	DRTGG domain; Region: DRTGG; pfam07085
393130005179	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
393130005180	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
393130005181	active site 2 [active]
393130005182	active site 1 [active]
393130005183	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
393130005184	metal-dependent hydrolase; Provisional; Region: PRK00685
393130005185	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
393130005186	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
393130005187	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
393130005188	active site
393130005189	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
393130005190	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
393130005191	hexamer interface [polypeptide binding]; other site
393130005192	ligand binding site [chemical binding]; other site
393130005193	putative active site [active]
393130005194	NAD(P) binding site [chemical binding]; other site
393130005195	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393130005196	Ligand Binding Site [chemical binding]; other site
393130005197	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
393130005198	propionate/acetate kinase; Provisional; Region: PRK12379
393130005199	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
393130005200	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005201	S-adenosylmethionine binding site [chemical binding]; other site
393130005202	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
393130005203	dimer interface [polypeptide binding]; other site
393130005204	catalytic triad [active]
393130005205	peroxidatic and resolving cysteines [active]
393130005206	RDD family; Region: RDD; pfam06271
393130005207	Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616
393130005208	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
393130005209	tandem repeat interface [polypeptide binding]; other site
393130005210	oligomer interface [polypeptide binding]; other site
393130005211	active site residues [active]
393130005212	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501
393130005213	ATP-NAD kinase; Region: NAD_kinase; pfam01513
393130005214	ornithine carbamoyltransferase; Provisional; Region: PRK00779
393130005215	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393130005216	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393130005217	acetylornithine aminotransferase; Provisional; Region: argD; PRK02936
393130005218	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393130005219	inhibitor-cofactor binding pocket; inhibition site
393130005220	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005221	catalytic residue [active]
393130005222	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
393130005223	nucleotide binding site [chemical binding]; other site
393130005224	N-acetyl-L-glutamate binding site [chemical binding]; other site
393130005225	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
393130005226	heterotetramer interface [polypeptide binding]; other site
393130005227	active site pocket [active]
393130005228	cleavage site
393130005229	N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850
393130005230	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
393130005231	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
393130005232	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
393130005233	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
393130005234	Ligand Binding Site [chemical binding]; other site
393130005235	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393130005236	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393130005237	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130005238	catalytic residue [active]
393130005239	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
393130005240	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
393130005241	GAF domain; Region: GAF_2; pfam13185
393130005242	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
393130005243	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
393130005244	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130005245	RNA binding surface [nucleotide binding]; other site
393130005246	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
393130005247	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
393130005248	active site
393130005249	HIGH motif; other site
393130005250	dimer interface [polypeptide binding]; other site
393130005251	KMSKS motif; other site
393130005252	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130005253	RNA binding surface [nucleotide binding]; other site
393130005254	catabolite control protein A; Region: ccpA; TIGR01481
393130005255	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130005256	DNA binding site [nucleotide binding]
393130005257	domain linker motif; other site
393130005258	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
393130005259	dimerization interface [polypeptide binding]; other site
393130005260	effector binding site; other site
393130005261	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
393130005262	Chorismate mutase type II; Region: CM_2; cl00693
393130005263	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
393130005264	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
393130005265	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
393130005266	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
393130005267	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
393130005268	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
393130005269	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
393130005270	dimer interface [polypeptide binding]; other site
393130005271	decamer (pentamer of dimers) interface [polypeptide binding]; other site
393130005272	catalytic triad [active]
393130005273	peroxidatic and resolving cysteines [active]
393130005274	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
393130005275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393130005276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393130005277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393130005278	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
393130005279	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
393130005280	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
393130005281	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
393130005282	putative tRNA-binding site [nucleotide binding]; other site
393130005283	hypothetical protein; Provisional; Region: PRK13668
393130005284	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130005285	catalytic residues [active]
393130005286	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
393130005287	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
393130005288	oligomer interface [polypeptide binding]; other site
393130005289	active site
393130005290	metal binding site [ion binding]; metal-binding site
393130005291	Predicted small secreted protein [Function unknown]; Region: COG5584
393130005292	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937
393130005293	putative homodimer interface [polypeptide binding]; other site
393130005294	putative homotetramer interface [polypeptide binding]; other site
393130005295	putative allosteric switch controlling residues; other site
393130005296	putative metal binding site [ion binding]; other site
393130005297	putative homodimer-homodimer interface [polypeptide binding]; other site
393130005298	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130005299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005300	S-adenosylmethionine binding site [chemical binding]; other site
393130005301	Phosphotransferase enzyme family; Region: APH; pfam01636
393130005302	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
393130005303	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
393130005304	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130005305	putative substrate translocation pore; other site
393130005306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130005307	MarR family; Region: MarR; pfam01047
393130005308	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
393130005309	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
393130005310	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
393130005311	homodimer interface [polypeptide binding]; other site
393130005312	substrate-cofactor binding pocket; other site
393130005313	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005314	catalytic residue [active]
393130005315	dipeptidase PepV; Reviewed; Region: PRK07318
393130005316	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
393130005317	active site
393130005318	metal binding site [ion binding]; metal-binding site
393130005319	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699
393130005320	nudix motif; other site
393130005321	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
393130005322	putative substrate binding site [chemical binding]; other site
393130005323	putative ATP binding site [chemical binding]; other site
393130005324	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
393130005325	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
393130005326	active site
393130005327	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393130005328	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393130005329	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
393130005330	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
393130005331	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
393130005332	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
393130005333	substrate binding site [chemical binding]; other site
393130005334	active site
393130005335	catalytic residues [active]
393130005336	heterodimer interface [polypeptide binding]; other site
393130005337	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
393130005338	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
393130005339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005340	catalytic residue [active]
393130005341	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
393130005342	active site
393130005343	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
393130005344	active site
393130005345	ribulose/triose binding site [chemical binding]; other site
393130005346	phosphate binding site [ion binding]; other site
393130005347	substrate (anthranilate) binding pocket [chemical binding]; other site
393130005348	product (indole) binding pocket [chemical binding]; other site
393130005349	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
393130005350	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
393130005351	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
393130005352	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
393130005353	Glutamine amidotransferase class-I; Region: GATase; pfam00117
393130005354	glutamine binding [chemical binding]; other site
393130005355	catalytic triad [active]
393130005356	anthranilate synthase component I; Provisional; Region: PRK13570
393130005357	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
393130005358	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
393130005359	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
393130005360	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
393130005361	putative catalytic cysteine [active]
393130005362	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
393130005363	putative active site [active]
393130005364	metal binding site [ion binding]; metal-binding site
393130005365	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393130005366	dimer interface [polypeptide binding]; other site
393130005367	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130005368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130005369	Walker A/P-loop; other site
393130005370	ATP binding site [chemical binding]; other site
393130005371	Q-loop/lid; other site
393130005372	ABC transporter signature motif; other site
393130005373	Walker B; other site
393130005374	D-loop; other site
393130005375	H-loop/switch region; other site
393130005376	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393130005377	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
393130005378	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
393130005379	putative dimer interface [polypeptide binding]; other site
393130005380	catalytic triad [active]
393130005381	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
393130005382	aconitate hydratase; Validated; Region: PRK09277
393130005383	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
393130005384	substrate binding site [chemical binding]; other site
393130005385	ligand binding site [chemical binding]; other site
393130005386	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
393130005387	substrate binding site [chemical binding]; other site
393130005388	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130005389	Heat induced stress protein YflT; Region: YflT; pfam11181
393130005390	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
393130005391	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
393130005392	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130005393	ATP binding site [chemical binding]; other site
393130005394	putative Mg++ binding site [ion binding]; other site
393130005395	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130005396	nucleotide binding region [chemical binding]; other site
393130005397	ATP-binding site [chemical binding]; other site
393130005398	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
393130005399	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
393130005400	Walker A/P-loop; other site
393130005401	ATP binding site [chemical binding]; other site
393130005402	Q-loop/lid; other site
393130005403	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
393130005404	ABC transporter signature motif; other site
393130005405	Walker B; other site
393130005406	D-loop; other site
393130005407	H-loop/switch region; other site
393130005408	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
393130005409	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
393130005410	active site
393130005411	metal binding site [ion binding]; metal-binding site
393130005412	DNA binding site [nucleotide binding]
393130005413	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
393130005414	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
393130005415	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
393130005416	putative acyl-acceptor binding pocket; other site
393130005417	Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846
393130005418	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130005419	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130005420	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
393130005421	Walker A/P-loop; other site
393130005422	ATP binding site [chemical binding]; other site
393130005423	Q-loop/lid; other site
393130005424	ABC transporter signature motif; other site
393130005425	Walker B; other site
393130005426	D-loop; other site
393130005427	H-loop/switch region; other site
393130005428	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130005429	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
393130005430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130005431	Walker A/P-loop; other site
393130005432	ATP binding site [chemical binding]; other site
393130005433	Q-loop/lid; other site
393130005434	ABC transporter signature motif; other site
393130005435	Walker B; other site
393130005436	D-loop; other site
393130005437	H-loop/switch region; other site
393130005438	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
393130005439	active site
393130005440	elongation factor Ts; Provisional; Region: tsf; PRK09377
393130005441	UBA/TS-N domain; Region: UBA; pfam00627
393130005442	Elongation factor TS; Region: EF_TS; pfam00889
393130005443	Elongation factor TS; Region: EF_TS; pfam00889
393130005444	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
393130005445	rRNA interaction site [nucleotide binding]; other site
393130005446	S8 interaction site; other site
393130005447	putative laminin-1 binding site; other site
393130005448	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
393130005449	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
393130005450	HIGH motif; other site
393130005451	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
393130005452	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
393130005453	active site
393130005454	KMSKS motif; other site
393130005455	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
393130005456	tRNA binding surface [nucleotide binding]; other site
393130005457	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
393130005458	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
393130005459	FeS/SAM binding site; other site
393130005460	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005461	S-adenosylmethionine binding site [chemical binding]; other site
393130005462	Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367
393130005463	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
393130005464	active site
393130005465	dimer interface [polypeptide binding]; other site
393130005466	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
393130005467	Ligand Binding Site [chemical binding]; other site
393130005468	Molecular Tunnel; other site
393130005469	S-adenosylmethionine synthetase; Validated; Region: PRK05250
393130005470	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
393130005471	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
393130005472	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
393130005473	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130005474	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130005475	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
393130005476	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
393130005477	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130005478	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
393130005479	NAD binding site [chemical binding]; other site
393130005480	dimer interface [polypeptide binding]; other site
393130005481	substrate binding site [chemical binding]; other site
393130005482	Protein of unknown function (DUF2584); Region: DUF2584; pfam10763
393130005483	nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705
393130005484	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665
393130005485	nudix motif; other site
393130005486	Uncharacterized conserved protein [Function unknown]; Region: COG0759
393130005487	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393130005488	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
393130005489	metal binding site [ion binding]; metal-binding site
393130005490	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640
393130005491	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
393130005492	acyl-activating enzyme (AAE) consensus motif; other site
393130005493	putative AMP binding site [chemical binding]; other site
393130005494	putative active site [active]
393130005495	putative CoA binding site [chemical binding]; other site
393130005496	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
393130005497	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
393130005498	substrate binding site [chemical binding]; other site
393130005499	oxyanion hole (OAH) forming residues; other site
393130005500	trimer interface [polypeptide binding]; other site
393130005501	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
393130005502	Serine hydrolase (FSH1); Region: FSH1; pfam03959
393130005503	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
393130005504	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165
393130005505	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
393130005506	dimer interface [polypeptide binding]; other site
393130005507	tetramer interface [polypeptide binding]; other site
393130005508	PYR/PP interface [polypeptide binding]; other site
393130005509	TPP binding site [chemical binding]; other site
393130005510	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
393130005511	TPP-binding site; other site
393130005512	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
393130005513	chorismate binding enzyme; Region: Chorismate_bind; cl10555
393130005514	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
393130005515	UbiA prenyltransferase family; Region: UbiA; pfam01040
393130005516	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
393130005517	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
393130005518	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
393130005519	FAD binding site [chemical binding]; other site
393130005520	cystathionine beta-lyase; Provisional; Region: PRK08064
393130005521	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393130005522	homodimer interface [polypeptide binding]; other site
393130005523	substrate-cofactor binding pocket; other site
393130005524	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005525	catalytic residue [active]
393130005526	cystathionine gamma-synthase; Reviewed; Region: PRK08247
393130005527	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
393130005528	homodimer interface [polypeptide binding]; other site
393130005529	substrate-cofactor binding pocket; other site
393130005530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005531	catalytic residue [active]
393130005532	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
393130005533	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
393130005534	THF binding site; other site
393130005535	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
393130005536	substrate binding site [chemical binding]; other site
393130005537	THF binding site; other site
393130005538	zinc-binding site [ion binding]; other site
393130005539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130005540	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130005541	putative substrate translocation pore; other site
393130005542	ferric uptake regulator; Provisional; Region: fur; PRK09462
393130005543	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393130005544	metal binding site 2 [ion binding]; metal-binding site
393130005545	putative DNA binding helix; other site
393130005546	metal binding site 1 [ion binding]; metal-binding site
393130005547	dimer interface [polypeptide binding]; other site
393130005548	structural Zn2+ binding site [ion binding]; other site
393130005549	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
393130005550	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
393130005551	NAD binding site [chemical binding]; other site
393130005552	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
393130005553	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
393130005554	inhibitor-cofactor binding pocket; inhibition site
393130005555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130005556	catalytic residue [active]
393130005557	Predicted membrane protein [Function unknown]; Region: COG4129
393130005558	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
393130005559	hypothetical protein; Provisional; Region: PRK13662
393130005560	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
393130005561	1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359
393130005562	putative NAD(P) binding site [chemical binding]; other site
393130005563	active site
393130005564	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
393130005565	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393130005566	minor groove reading motif; other site
393130005567	helix-hairpin-helix signature motif; other site
393130005568	substrate binding pocket [chemical binding]; other site
393130005569	active site
393130005570	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
393130005571	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
393130005572	DNA binding and oxoG recognition site [nucleotide binding]
393130005573	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
393130005574	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
393130005575	trimer interface [polypeptide binding]; other site
393130005576	active site
393130005577	WVELL protein; Region: WVELL; pfam14043
393130005578	recombination regulator RecX; Provisional; Region: recX; PRK14135
393130005579	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393130005580	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
393130005581	NAD(P) binding site [chemical binding]; other site
393130005582	active site
393130005583	Predicted integral membrane protein [Function unknown]; Region: COG0392
393130005584	Uncharacterized conserved protein [Function unknown]; Region: COG2898
393130005585	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
393130005586	Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767
393130005587	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393130005588	Cation efflux family; Region: Cation_efflux; pfam01545
393130005589	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393130005590	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
393130005591	PAS fold; Region: PAS_4; pfam08448
393130005592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
393130005593	putative active site [active]
393130005594	heme pocket [chemical binding]; other site
393130005595	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
393130005596	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
393130005597	dimer interface [polypeptide binding]; other site
393130005598	putative CheW interface [polypeptide binding]; other site
393130005599	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
393130005600	FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364
393130005601	dimer interface [polypeptide binding]; other site
393130005602	active site
393130005603	Mn binding site [ion binding]; other site
393130005604	TRAM domain; Region: TRAM; cl01282
393130005605	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
393130005606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005607	S-adenosylmethionine binding site [chemical binding]; other site
393130005608	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
393130005609	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
393130005610	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
393130005611	Substrate-binding site [chemical binding]; other site
393130005612	Substrate specificity [chemical binding]; other site
393130005613	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
393130005614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840
393130005615	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
393130005616	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
393130005617	active site
393130005618	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
393130005619	flavodoxin, short chain; Region: flav_short; TIGR01753
393130005620	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
393130005621	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
393130005622	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130005623	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130005624	putative substrate translocation pore; other site
393130005625	rod-share determining protein MreBH; Provisional; Region: PRK13929
393130005626	MreB and similar proteins; Region: MreB_like; cd10225
393130005627	nucleotide binding site [chemical binding]; other site
393130005628	Mg binding site [ion binding]; other site
393130005629	putative protofilament interaction site [polypeptide binding]; other site
393130005630	RodZ interaction site [polypeptide binding]; other site
393130005631	Methyltransferase domain; Region: Methyltransf_31; pfam13847
393130005632	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005633	S-adenosylmethionine binding site [chemical binding]; other site
393130005634	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130005635	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130005636	Uncharacterized conserved protein [Function unknown]; Region: COG4748
393130005637	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
393130005638	Uncharacterized conserved protein [Function unknown]; Region: COG3589
393130005639	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
393130005640	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130005641	methionine cluster; other site
393130005642	active site
393130005643	phosphorylation site [posttranslational modification]
393130005644	metal binding site [ion binding]; metal-binding site
393130005645	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130005646	active site
393130005647	P-loop; other site
393130005648	phosphorylation site [posttranslational modification]
393130005649	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
393130005650	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
393130005651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130005652	Walker A motif; other site
393130005653	ATP binding site [chemical binding]; other site
393130005654	Walker B motif; other site
393130005655	arginine finger; other site
393130005656	Transcriptional antiterminator [Transcription]; Region: COG3933
393130005657	PRD domain; Region: PRD; pfam00874
393130005658	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130005659	active pocket/dimerization site; other site
393130005660	active site
393130005661	phosphorylation site [posttranslational modification]
393130005662	PRD domain; Region: PRD; pfam00874
393130005663	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
393130005664	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393130005665	ATP binding site [chemical binding]; other site
393130005666	putative Mg++ binding site [ion binding]; other site
393130005667	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130005668	nucleotide binding region [chemical binding]; other site
393130005669	ATP-binding site [chemical binding]; other site
393130005670	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393130005671	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130005672	Walker A/P-loop; other site
393130005673	ATP binding site [chemical binding]; other site
393130005674	Q-loop/lid; other site
393130005675	ABC transporter signature motif; other site
393130005676	Walker B; other site
393130005677	D-loop; other site
393130005678	H-loop/switch region; other site
393130005679	Predicted transcriptional regulators [Transcription]; Region: COG1725
393130005680	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130005681	DNA-binding site [nucleotide binding]; DNA binding site
393130005682	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130005683	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130005684	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130005685	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130005686	DNA binding site [nucleotide binding]
393130005687	domain linker motif; other site
393130005688	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130005689	dimerization interface [polypeptide binding]; other site
393130005690	ligand binding site [chemical binding]; other site
393130005691	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
393130005692	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
393130005693	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
393130005694	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
393130005695	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393130005696	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130005697	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130005698	dimer interface [polypeptide binding]; other site
393130005699	conserved gate region; other site
393130005700	putative PBP binding loops; other site
393130005701	ABC-ATPase subunit interface; other site
393130005702	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130005703	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130005704	dimer interface [polypeptide binding]; other site
393130005705	conserved gate region; other site
393130005706	putative PBP binding loops; other site
393130005707	ABC-ATPase subunit interface; other site
393130005708	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
393130005709	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
393130005710	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
393130005711	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
393130005712	active site
393130005713	dimer interface [polypeptide binding]; other site
393130005714	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
393130005715	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
393130005716	active site
393130005717	FMN binding site [chemical binding]; other site
393130005718	substrate binding site [chemical binding]; other site
393130005719	3Fe-4S cluster binding site [ion binding]; other site
393130005720	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
393130005721	domain interface; other site
393130005722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130005723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130005724	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393130005725	putative dimerization interface [polypeptide binding]; other site
393130005726	Predicted acetyltransferase [General function prediction only]; Region: COG3153
393130005727	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
393130005728	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
393130005729	putative active site [active]
393130005730	metal binding site [ion binding]; metal-binding site
393130005731	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393130005732	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393130005733	substrate binding pocket [chemical binding]; other site
393130005734	membrane-bound complex binding site; other site
393130005735	hinge residues; other site
393130005736	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130005737	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130005738	Walker A/P-loop; other site
393130005739	ATP binding site [chemical binding]; other site
393130005740	Q-loop/lid; other site
393130005741	ABC transporter signature motif; other site
393130005742	Walker B; other site
393130005743	D-loop; other site
393130005744	H-loop/switch region; other site
393130005745	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130005746	dimer interface [polypeptide binding]; other site
393130005747	conserved gate region; other site
393130005748	putative PBP binding loops; other site
393130005749	ABC-ATPase subunit interface; other site
393130005750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
393130005751	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
393130005752	dimer interface [polypeptide binding]; other site
393130005753	phosphorylation site [posttranslational modification]
393130005754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130005755	ATP binding site [chemical binding]; other site
393130005756	Mg2+ binding site [ion binding]; other site
393130005757	G-X-G motif; other site
393130005758	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
393130005759	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393130005760	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
393130005761	active site
393130005762	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
393130005763	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
393130005764	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
393130005765	putative NAD(P) binding site [chemical binding]; other site
393130005766	active site
393130005767	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130005768	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130005769	active site
393130005770	phosphorylation site [posttranslational modification]
393130005771	intermolecular recognition site; other site
393130005772	dimerization interface [polypeptide binding]; other site
393130005773	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130005774	DNA binding site [nucleotide binding]
393130005775	FtsX-like permease family; Region: FtsX; pfam02687
393130005776	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393130005777	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130005778	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130005779	Walker A/P-loop; other site
393130005780	ATP binding site [chemical binding]; other site
393130005781	Q-loop/lid; other site
393130005782	ABC transporter signature motif; other site
393130005783	Walker B; other site
393130005784	D-loop; other site
393130005785	H-loop/switch region; other site
393130005786	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
393130005787	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
393130005788	ADP binding site [chemical binding]; other site
393130005789	magnesium binding site [ion binding]; other site
393130005790	putative shikimate binding site; other site
393130005791	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884
393130005792	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
393130005793	TRAM domain; Region: TRAM; pfam01938
393130005794	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130005795	S-adenosylmethionine binding site [chemical binding]; other site
393130005796	putative lipid kinase; Reviewed; Region: PRK13337
393130005797	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393130005798	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
393130005799	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
393130005800	GatB domain; Region: GatB_Yqey; pfam02637
393130005801	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
393130005802	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
393130005803	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
393130005804	Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851
393130005805	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
393130005806	putative dimer interface [polypeptide binding]; other site
393130005807	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
393130005808	putative dimer interface [polypeptide binding]; other site
393130005809	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
393130005810	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
393130005811	nucleotide binding pocket [chemical binding]; other site
393130005812	K-X-D-G motif; other site
393130005813	catalytic site [active]
393130005814	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
393130005815	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
393130005816	Dimer interface [polypeptide binding]; other site
393130005817	BRCT sequence motif; other site
393130005818	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
393130005819	Part of AAA domain; Region: AAA_19; pfam13245
393130005820	Family description; Region: UvrD_C_2; pfam13538
393130005821	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
393130005822	PcrB family; Region: PcrB; pfam01884
393130005823	substrate binding site [chemical binding]; other site
393130005824	putative active site [active]
393130005825	dimer interface [polypeptide binding]; other site
393130005826	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
393130005827	Na2 binding site [ion binding]; other site
393130005828	putative substrate binding site 1 [chemical binding]; other site
393130005829	Na binding site 1 [ion binding]; other site
393130005830	putative substrate binding site 2 [chemical binding]; other site
393130005831	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496
393130005832	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
393130005833	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
393130005834	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
393130005835	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
393130005836	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
393130005837	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
393130005838	purine monophosphate binding site [chemical binding]; other site
393130005839	dimer interface [polypeptide binding]; other site
393130005840	putative catalytic residues [active]
393130005841	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
393130005842	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
393130005843	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
393130005844	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
393130005845	active site
393130005846	substrate binding site [chemical binding]; other site
393130005847	cosubstrate binding site; other site
393130005848	catalytic site [active]
393130005849	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
393130005850	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
393130005851	dimerization interface [polypeptide binding]; other site
393130005852	putative ATP binding site [chemical binding]; other site
393130005853	amidophosphoribosyltransferase; Provisional; Region: PRK06781
393130005854	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
393130005855	active site
393130005856	tetramer interface [polypeptide binding]; other site
393130005857	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130005858	active site
393130005859	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
393130005860	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
393130005861	dimerization interface [polypeptide binding]; other site
393130005862	ATP binding site [chemical binding]; other site
393130005863	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
393130005864	dimerization interface [polypeptide binding]; other site
393130005865	ATP binding site [chemical binding]; other site
393130005866	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
393130005867	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
393130005868	putative active site [active]
393130005869	catalytic triad [active]
393130005870	phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974
393130005871	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
393130005872	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
393130005873	ATP binding site [chemical binding]; other site
393130005874	active site
393130005875	substrate binding site [chemical binding]; other site
393130005876	adenylosuccinate lyase; Provisional; Region: PRK07492
393130005877	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
393130005878	tetramer interface [polypeptide binding]; other site
393130005879	active site
393130005880	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
393130005881	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
393130005882	NAD binding site [chemical binding]; other site
393130005883	ATP-grasp domain; Region: ATP-grasp; pfam02222
393130005884	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
393130005885	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843
393130005886	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130005887	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
393130005888	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130005889	Zn2+ binding site [ion binding]; other site
393130005890	Mg2+ binding site [ion binding]; other site
393130005891	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393130005892	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393130005893	Walker A/P-loop; other site
393130005894	ATP binding site [chemical binding]; other site
393130005895	Q-loop/lid; other site
393130005896	ABC transporter signature motif; other site
393130005897	Walker B; other site
393130005898	D-loop; other site
393130005899	H-loop/switch region; other site
393130005900	peptidase T; Region: peptidase-T; TIGR01882
393130005901	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
393130005902	metal binding site [ion binding]; metal-binding site
393130005903	dimer interface [polypeptide binding]; other site
393130005904	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
393130005905	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
393130005906	active site
393130005907	putative catalytic site [active]
393130005908	DNA binding site [nucleotide binding]
393130005909	putative phosphate binding site [ion binding]; other site
393130005910	metal binding site A [ion binding]; metal-binding site
393130005911	AP binding site [nucleotide binding]; other site
393130005912	metal binding site B [ion binding]; metal-binding site
393130005913	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
393130005914	23S rRNA binding site [nucleotide binding]; other site
393130005915	L21 binding site [polypeptide binding]; other site
393130005916	L13 binding site [polypeptide binding]; other site
393130005917	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
393130005918	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
393130005919	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
393130005920	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
393130005921	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130005922	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130005923	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130005924	Substrate binding site [chemical binding]; other site
393130005925	Leucine rich repeat; Region: LRR_8; pfam13855
393130005926	LRR adjacent; Region: LRR_adjacent; pfam08191
393130005927	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
393130005928	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
393130005929	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393130005930	DNA binding residues [nucleotide binding]
393130005931	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393130005932	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393130005933	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130005934	Putative heavy-metal-binding; Region: YbjQ_1; pfam01906
393130005935	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
393130005936	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
393130005937	RimM N-terminal domain; Region: RimM; pfam01782
393130005938	PRC-barrel domain; Region: PRC; pfam05239
393130005939	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
393130005940	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
393130005941	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
393130005942	catalytic triad [active]
393130005943	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
393130005944	KH domain; Region: KH_4; pfam13083
393130005945	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
393130005946	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
393130005947	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
393130005948	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
393130005949	signal recognition particle protein; Provisional; Region: PRK10867
393130005950	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
393130005951	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
393130005952	P loop; other site
393130005953	GTP binding site [chemical binding]; other site
393130005954	Signal peptide binding domain; Region: SRP_SPB; pfam02978
393130005955	putative DNA-binding protein; Validated; Region: PRK00118
393130005956	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
393130005957	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
393130005958	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
393130005959	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
393130005960	P loop; other site
393130005961	GTP binding site [chemical binding]; other site
393130005962	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
393130005963	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
393130005964	Walker A/P-loop; other site
393130005965	ATP binding site [chemical binding]; other site
393130005966	Q-loop/lid; other site
393130005967	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
393130005968	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
393130005969	ABC transporter signature motif; other site
393130005970	Walker B; other site
393130005971	D-loop; other site
393130005972	H-loop/switch region; other site
393130005973	ribonuclease III; Reviewed; Region: rnc; PRK00102
393130005974	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
393130005975	dimerization interface [polypeptide binding]; other site
393130005976	active site
393130005977	metal binding site [ion binding]; metal-binding site
393130005978	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
393130005979	dsRNA binding site [nucleotide binding]; other site
393130005980	acyl carrier protein; Provisional; Region: acpP; PRK00982
393130005981	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
393130005982	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
393130005983	NAD(P) binding site [chemical binding]; other site
393130005984	homotetramer interface [polypeptide binding]; other site
393130005985	homodimer interface [polypeptide binding]; other site
393130005986	active site
393130005987	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
393130005988	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
393130005989	putative phosphate acyltransferase; Provisional; Region: PRK05331
393130005990	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
393130005991	HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis,    transport, and catabolism]; Region: PaaI; COG2050
393130005992	active site 2 [active]
393130005993	active site 1 [active]
393130005994	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
393130005995	Y-family of DNA polymerases; Region: PolY; cl12025
393130005996	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
393130005997	generic binding surface II; other site
393130005998	ssDNA binding site; other site
393130005999	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130006000	ATP binding site [chemical binding]; other site
393130006001	putative Mg++ binding site [ion binding]; other site
393130006002	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130006003	nucleotide binding region [chemical binding]; other site
393130006004	ATP-binding site [chemical binding]; other site
393130006005	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
393130006006	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
393130006007	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
393130006008	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
393130006009	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
393130006010	putative L-serine binding site [chemical binding]; other site
393130006011	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
393130006012	DAK2 domain; Region: Dak2; pfam02734
393130006013	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
393130006014	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
393130006015	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
393130006016	Thiamine pyrophosphokinase; Region: TPK; cd07995
393130006017	active site
393130006018	dimerization interface [polypeptide binding]; other site
393130006019	thiamine binding site [chemical binding]; other site
393130006020	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130006021	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130006022	substrate binding site [chemical binding]; other site
393130006023	hexamer interface [polypeptide binding]; other site
393130006024	metal binding site [ion binding]; metal-binding site
393130006025	GTPase RsgA; Reviewed; Region: PRK00098
393130006026	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
393130006027	RNA binding site [nucleotide binding]; other site
393130006028	homodimer interface [polypeptide binding]; other site
393130006029	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
393130006030	GTPase/Zn-binding domain interface [polypeptide binding]; other site
393130006031	GTP/Mg2+ binding site [chemical binding]; other site
393130006032	G4 box; other site
393130006033	G1 box; other site
393130006034	Switch I region; other site
393130006035	G2 box; other site
393130006036	G3 box; other site
393130006037	Switch II region; other site
393130006038	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
393130006039	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
393130006040	active site
393130006041	ATP binding site [chemical binding]; other site
393130006042	substrate binding site [chemical binding]; other site
393130006043	activation loop (A-loop); other site
393130006044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
393130006045	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393130006046	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393130006047	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
393130006048	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
393130006049	Protein phosphatase 2C; Region: PP2C; pfam00481
393130006050	active site
393130006051	16S rRNA methyltransferase B; Provisional; Region: PRK14902
393130006052	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
393130006053	putative RNA binding site [nucleotide binding]; other site
393130006054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130006055	S-adenosylmethionine binding site [chemical binding]; other site
393130006056	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
393130006057	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
393130006058	putative active site [active]
393130006059	substrate binding site [chemical binding]; other site
393130006060	putative cosubstrate binding site; other site
393130006061	catalytic site [active]
393130006062	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
393130006063	substrate binding site [chemical binding]; other site
393130006064	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
393130006065	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130006066	ATP binding site [chemical binding]; other site
393130006067	putative Mg++ binding site [ion binding]; other site
393130006068	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130006069	ATP-binding site [chemical binding]; other site
393130006070	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
393130006071	Flavoprotein; Region: Flavoprotein; pfam02441
393130006072	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
393130006073	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
393130006074	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
393130006075	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
393130006076	catalytic site [active]
393130006077	G-X2-G-X-G-K; other site
393130006078	Uncharacterized stress-induced protein [Function unknown]; Region: COG1561
393130006079	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
393130006080	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
393130006081	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
393130006082	Domain of unknown function (DUF814); Region: DUF814; pfam05670
393130006083	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
393130006084	putative NAD(P) binding site [chemical binding]; other site
393130006085	homodimer interface [polypeptide binding]; other site
393130006086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130006087	active site
393130006088	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
393130006089	active site
393130006090	dimer interface [polypeptide binding]; other site
393130006091	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
393130006092	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
393130006093	heterodimer interface [polypeptide binding]; other site
393130006094	active site
393130006095	FMN binding site [chemical binding]; other site
393130006096	homodimer interface [polypeptide binding]; other site
393130006097	substrate binding site [chemical binding]; other site
393130006098	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
393130006099	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
393130006100	FAD binding pocket [chemical binding]; other site
393130006101	FAD binding motif [chemical binding]; other site
393130006102	phosphate binding motif [ion binding]; other site
393130006103	beta-alpha-beta structure motif; other site
393130006104	NAD binding pocket [chemical binding]; other site
393130006105	Iron coordination center [ion binding]; other site
393130006106	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
393130006107	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393130006108	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
393130006109	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
393130006110	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
393130006111	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393130006112	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
393130006113	IMP binding site; other site
393130006114	dimer interface [polypeptide binding]; other site
393130006115	interdomain contacts; other site
393130006116	partial ornithine binding site; other site
393130006117	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
393130006118	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
393130006119	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
393130006120	catalytic site [active]
393130006121	subunit interface [polypeptide binding]; other site
393130006122	dihydroorotase; Validated; Region: pyrC; PRK09357
393130006123	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
393130006124	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
393130006125	active site
393130006126	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
393130006127	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
393130006128	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
393130006129	uracil transporter; Provisional; Region: PRK10720
393130006130	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
393130006131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130006132	active site
393130006133	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
393130006134	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393130006135	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130006136	RNA binding surface [nucleotide binding]; other site
393130006137	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393130006138	active site
393130006139	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
393130006140	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393130006141	Sulfate transporter family; Region: Sulfate_transp; pfam00916
393130006142	multidrug efflux protein; Reviewed; Region: PRK01766
393130006143	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
393130006144	cation binding site [ion binding]; other site
393130006145	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
393130006146	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
393130006147	metal binding site [ion binding]; metal-binding site
393130006148	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
393130006149	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130006150	ABC-ATPase subunit  interface; other site
393130006151	dimer interface [polypeptide binding]; other site
393130006152	putative PBP binding regions; other site
393130006153	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
393130006154	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
393130006155	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130006156	MarR family; Region: MarR; pfam01047
393130006157	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
393130006158	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
393130006159	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
393130006160	protein binding site [polypeptide binding]; other site
393130006161	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
393130006162	Catalytic dyad [active]
393130006163	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
393130006164	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
393130006165	metal-binding site [ion binding]
393130006166	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
393130006167	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
393130006168	metal-binding site [ion binding]
393130006169	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130006170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130006171	motif II; other site
393130006172	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
393130006173	putative homodimer interface [polypeptide binding]; other site
393130006174	putative homotetramer interface [polypeptide binding]; other site
393130006175	putative allosteric switch controlling residues; other site
393130006176	putative metal binding site [ion binding]; other site
393130006177	putative homodimer-homodimer interface [polypeptide binding]; other site
393130006178	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
393130006179	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
393130006180	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
393130006181	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
393130006182	hypothetical protein; Provisional; Region: PRK13672
393130006183	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130006184	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130006185	methionine sulfoxide reductase B; Provisional; Region: PRK00222
393130006186	SelR domain; Region: SelR; pfam01641
393130006187	methionine sulfoxide reductase A; Provisional; Region: PRK14054
393130006188	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698
393130006189	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
393130006190	active site
393130006191	catalytic triad [active]
393130006192	oxyanion hole [active]
393130006193	EDD domain protein, DegV family; Region: DegV; TIGR00762
393130006194	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393130006195	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
393130006196	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
393130006197	HTH domain; Region: HTH_11; pfam08279
393130006198	FOG: CBS domain [General function prediction only]; Region: COG0517
393130006199	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
393130006200	PEP synthetase regulatory protein; Provisional; Region: PRK05339
393130006201	pyruvate phosphate dikinase; Provisional; Region: PRK09279
393130006202	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
393130006203	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
393130006204	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
393130006205	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130006206	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
393130006207	Predicted membrane protein [Function unknown]; Region: COG4129
393130006208	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
393130006209	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
393130006210	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
393130006211	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
393130006212	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
393130006213	active site
393130006214	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
393130006215	substrate binding site [chemical binding]; other site
393130006216	metal binding site [ion binding]; metal-binding site
393130006217	Methyltransferase domain; Region: Methyltransf_23; pfam13489
393130006218	Methyltransferase domain; Region: Methyltransf_18; pfam12847
393130006219	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
393130006220	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
393130006221	folate binding site [chemical binding]; other site
393130006222	NADP+ binding site [chemical binding]; other site
393130006223	thymidylate synthase; Region: thym_sym; TIGR03284
393130006224	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
393130006225	dimerization interface [polypeptide binding]; other site
393130006226	active site
393130006227	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393130006228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130006229	Walker A/P-loop; other site
393130006230	ATP binding site [chemical binding]; other site
393130006231	Q-loop/lid; other site
393130006232	ABC transporter signature motif; other site
393130006233	Walker B; other site
393130006234	D-loop; other site
393130006235	H-loop/switch region; other site
393130006236	ABC transporter; Region: ABC_tran_2; pfam12848
393130006237	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130006238	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
393130006239	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
393130006240	Potassium binding sites [ion binding]; other site
393130006241	Cesium cation binding sites [ion binding]; other site
393130006242	manganese transport transcriptional regulator; Provisional; Region: PRK03902
393130006243	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
393130006244	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
393130006245	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393130006246	DNA-binding site [nucleotide binding]; DNA binding site
393130006247	RNA-binding motif; other site
393130006248	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
393130006249	RNA/DNA hybrid binding site [nucleotide binding]; other site
393130006250	active site
393130006251	5'-3' exonuclease; Region: 53EXOc; smart00475
393130006252	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
393130006253	active site
393130006254	metal binding site 1 [ion binding]; metal-binding site
393130006255	putative 5' ssDNA interaction site; other site
393130006256	metal binding site 3; metal-binding site
393130006257	metal binding site 2 [ion binding]; metal-binding site
393130006258	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
393130006259	putative DNA binding site [nucleotide binding]; other site
393130006260	putative metal binding site [ion binding]; other site
393130006261	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
393130006262	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
393130006263	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
393130006264	putative active site [active]
393130006265	xanthine permease; Region: pbuX; TIGR03173
393130006266	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130006267	active site
393130006268	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
393130006269	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
393130006270	active site
393130006271	Zn binding site [ion binding]; other site
393130006272	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
393130006273	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
393130006274	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
393130006275	cell division protein GpsB; Provisional; Region: PRK14127
393130006276	DivIVA domain; Region: DivI1A_domain; TIGR03544
393130006277	Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884
393130006278	hypothetical protein; Provisional; Region: PRK13660
393130006279	Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807
393130006280	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
393130006281	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
393130006282	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
393130006283	minor groove reading motif; other site
393130006284	helix-hairpin-helix signature motif; other site
393130006285	substrate binding pocket [chemical binding]; other site
393130006286	active site
393130006287	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
393130006288	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
393130006289	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
393130006290	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
393130006291	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
393130006292	putative dimer interface [polypeptide binding]; other site
393130006293	putative anticodon binding site; other site
393130006294	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
393130006295	homodimer interface [polypeptide binding]; other site
393130006296	motif 1; other site
393130006297	motif 2; other site
393130006298	active site
393130006299	motif 3; other site
393130006300	aspartate aminotransferase; Provisional; Region: PRK05764
393130006301	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130006302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130006303	homodimer interface [polypeptide binding]; other site
393130006304	catalytic residue [active]
393130006305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
393130006306	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
393130006307	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
393130006308	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
393130006309	active site
393130006310	catalytic site [active]
393130006311	substrate binding site [chemical binding]; other site
393130006312	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
393130006313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
393130006314	putative Mg++ binding site [ion binding]; other site
393130006315	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
393130006316	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
393130006317	tetramerization interface [polypeptide binding]; other site
393130006318	active site
393130006319	pantoate--beta-alanine ligase; Region: panC; TIGR00018
393130006320	Pantoate-beta-alanine ligase; Region: PanC; cd00560
393130006321	active site
393130006322	ATP-binding site [chemical binding]; other site
393130006323	pantoate-binding site; other site
393130006324	HXXH motif; other site
393130006325	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
393130006326	active site
393130006327	oligomerization interface [polypeptide binding]; other site
393130006328	metal binding site [ion binding]; metal-binding site
393130006329	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130006330	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393130006331	catalytic residues [active]
393130006332	Biotin operon repressor [Transcription]; Region: BirA; COG1654
393130006333	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
393130006334	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
393130006335	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
393130006336	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
393130006337	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
393130006338	active site
393130006339	NTP binding site [chemical binding]; other site
393130006340	metal binding triad [ion binding]; metal-binding site
393130006341	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
393130006342	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
393130006343	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
393130006344	active site
393130006345	dimer interfaces [polypeptide binding]; other site
393130006346	catalytic residues [active]
393130006347	dihydrodipicolinate reductase; Provisional; Region: PRK00048
393130006348	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
393130006349	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
393130006350	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
393130006351	homodimer interface [polypeptide binding]; other site
393130006352	metal binding site [ion binding]; metal-binding site
393130006353	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393130006354	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130006355	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130006356	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130006357	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
393130006358	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393130006359	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393130006360	metal binding site [ion binding]; metal-binding site
393130006361	active site
393130006362	I-site; other site
393130006363	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
393130006364	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393130006365	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393130006366	metal binding site [ion binding]; metal-binding site
393130006367	active site
393130006368	I-site; other site
393130006369	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
393130006370	malate dehydrogenase; Provisional; Region: PRK13529
393130006371	Malic enzyme, N-terminal domain; Region: malic; pfam00390
393130006372	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
393130006373	NAD(P) binding pocket [chemical binding]; other site
393130006374	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
393130006375	Beta-lactamase; Region: Beta-lactamase; pfam00144
393130006376	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
393130006377	Pyruvate formate lyase 1; Region: PFL1; cd01678
393130006378	coenzyme A binding site [chemical binding]; other site
393130006379	active site
393130006380	catalytic residues [active]
393130006381	glycine loop; other site
393130006382	HI0933-like protein; Region: HI0933_like; pfam03486
393130006383	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130006384	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
393130006385	Predicted membrane protein [Function unknown]; Region: COG4347
393130006386	hypothetical protein; Provisional; Region: PRK03636
393130006387	UPF0302 domain; Region: UPF0302; pfam08864
393130006388	IDEAL domain; Region: IDEAL; pfam08858
393130006389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
393130006390	binding surface
393130006391	TPR motif; other site
393130006392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130006393	binding surface
393130006394	Tetratricopeptide repeat; Region: TPR_16; pfam13432
393130006395	TPR motif; other site
393130006396	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
393130006397	binding surface
393130006398	TPR motif; other site
393130006399	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
393130006400	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
393130006401	hinge; other site
393130006402	active site
393130006403	prephenate dehydrogenase; Validated; Region: PRK06545
393130006404	prephenate dehydrogenase; Validated; Region: PRK08507
393130006405	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
393130006406	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
393130006407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130006408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130006409	homodimer interface [polypeptide binding]; other site
393130006410	catalytic residue [active]
393130006411	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
393130006412	homotrimer interaction site [polypeptide binding]; other site
393130006413	active site
393130006414	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
393130006415	active site
393130006416	dimer interface [polypeptide binding]; other site
393130006417	metal binding site [ion binding]; metal-binding site
393130006418	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
393130006419	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
393130006420	Tetramer interface [polypeptide binding]; other site
393130006421	active site
393130006422	FMN-binding site [chemical binding]; other site
393130006423	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
393130006424	active site
393130006425	multimer interface [polypeptide binding]; other site
393130006426	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393130006427	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393130006428	substrate binding pocket [chemical binding]; other site
393130006429	chain length determination region; other site
393130006430	substrate-Mg2+ binding site; other site
393130006431	catalytic residues [active]
393130006432	aspartate-rich region 1; other site
393130006433	active site lid residues [active]
393130006434	aspartate-rich region 2; other site
393130006435	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
393130006436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130006437	S-adenosylmethionine binding site [chemical binding]; other site
393130006438	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
393130006439	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
393130006440	homodecamer interface [polypeptide binding]; other site
393130006441	GTP cyclohydrolase I; Provisional; Region: PLN03044
393130006442	active site
393130006443	putative catalytic site residues [active]
393130006444	zinc binding site [ion binding]; other site
393130006445	GTP-CH-I/GFRP interaction surface; other site
393130006446	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
393130006447	IHF dimer interface [polypeptide binding]; other site
393130006448	IHF - DNA interface [nucleotide binding]; other site
393130006449	Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365
393130006450	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
393130006451	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
393130006452	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
393130006453	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
393130006454	GTP-binding protein Der; Reviewed; Region: PRK00093
393130006455	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
393130006456	G1 box; other site
393130006457	GTP/Mg2+ binding site [chemical binding]; other site
393130006458	Switch I region; other site
393130006459	G2 box; other site
393130006460	Switch II region; other site
393130006461	G3 box; other site
393130006462	G4 box; other site
393130006463	G5 box; other site
393130006464	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
393130006465	G1 box; other site
393130006466	GTP/Mg2+ binding site [chemical binding]; other site
393130006467	Switch I region; other site
393130006468	G2 box; other site
393130006469	G3 box; other site
393130006470	Switch II region; other site
393130006471	G4 box; other site
393130006472	G5 box; other site
393130006473	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
393130006474	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
393130006475	RNA binding site [nucleotide binding]; other site
393130006476	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
393130006477	RNA binding site [nucleotide binding]; other site
393130006478	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
393130006479	RNA binding site [nucleotide binding]; other site
393130006480	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393130006481	RNA binding site [nucleotide binding]; other site
393130006482	cytidylate kinase; Provisional; Region: cmk; PRK00023
393130006483	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
393130006484	CMP-binding site; other site
393130006485	The sites determining sugar specificity; other site
393130006486	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
393130006487	active site
393130006488	homotetramer interface [polypeptide binding]; other site
393130006489	homodimer interface [polypeptide binding]; other site
393130006490	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130006491	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
393130006492	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
393130006493	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130006494	ATP binding site [chemical binding]; other site
393130006495	putative Mg++ binding site [ion binding]; other site
393130006496	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130006497	nucleotide binding region [chemical binding]; other site
393130006498	ATP-binding site [chemical binding]; other site
393130006499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
393130006500	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
393130006501	Predicted membrane protein [Function unknown]; Region: COG3601
393130006502	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
393130006503	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
393130006504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130006505	dimerization interface [polypeptide binding]; other site
393130006506	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
393130006507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130006508	dimer interface [polypeptide binding]; other site
393130006509	phosphorylation site [posttranslational modification]
393130006510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130006511	ATP binding site [chemical binding]; other site
393130006512	Mg2+ binding site [ion binding]; other site
393130006513	G-X-G motif; other site
393130006514	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130006515	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130006516	active site
393130006517	phosphorylation site [posttranslational modification]
393130006518	intermolecular recognition site; other site
393130006519	dimerization interface [polypeptide binding]; other site
393130006520	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130006521	DNA binding site [nucleotide binding]
393130006522	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
393130006523	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130006524	RNA binding surface [nucleotide binding]; other site
393130006525	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
393130006526	active site
393130006527	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
393130006528	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
393130006529	diaminopimelate decarboxylase; Region: lysA; TIGR01048
393130006530	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
393130006531	active site
393130006532	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393130006533	substrate binding site [chemical binding]; other site
393130006534	catalytic residues [active]
393130006535	dimer interface [polypeptide binding]; other site
393130006536	purine nucleoside phosphorylase; Provisional; Region: PRK08202
393130006537	phosphopentomutase; Provisional; Region: PRK05362
393130006538	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
393130006539	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
393130006540	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
393130006541	active site
393130006542	Int/Topo IB signature motif; other site
393130006543	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
393130006544	metal binding site 2 [ion binding]; metal-binding site
393130006545	putative DNA binding helix; other site
393130006546	metal binding site 1 [ion binding]; metal-binding site
393130006547	dimer interface [polypeptide binding]; other site
393130006548	structural Zn2+ binding site [ion binding]; other site
393130006549	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393130006550	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130006551	ABC-ATPase subunit  interface; other site
393130006552	dimer interface [polypeptide binding]; other site
393130006553	putative PBP binding regions; other site
393130006554	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393130006555	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130006556	ABC-ATPase subunit  interface; other site
393130006557	dimer interface [polypeptide binding]; other site
393130006558	putative PBP binding regions; other site
393130006559	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
393130006560	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
393130006561	putative ligand binding residues [chemical binding]; other site
393130006562	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393130006563	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393130006564	Walker A/P-loop; other site
393130006565	ATP binding site [chemical binding]; other site
393130006566	Q-loop/lid; other site
393130006567	ABC transporter signature motif; other site
393130006568	Walker B; other site
393130006569	D-loop; other site
393130006570	H-loop/switch region; other site
393130006571	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
393130006572	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130006573	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130006574	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130006575	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
393130006576	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393130006577	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130006578	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130006579	Walker A/P-loop; other site
393130006580	ATP binding site [chemical binding]; other site
393130006581	Q-loop/lid; other site
393130006582	ABC transporter signature motif; other site
393130006583	Walker B; other site
393130006584	D-loop; other site
393130006585	H-loop/switch region; other site
393130006586	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
393130006587	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
393130006588	dimer interface [polypeptide binding]; other site
393130006589	ADP-ribose binding site [chemical binding]; other site
393130006590	active site
393130006591	nudix motif; other site
393130006592	metal binding site [ion binding]; metal-binding site
393130006593	5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915
393130006594	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
393130006595	Creatinine amidohydrolase; Region: Creatininase; pfam02633
393130006596	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
393130006597	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
393130006598	active site
393130006599	intersubunit interface [polypeptide binding]; other site
393130006600	catalytic residue [active]
393130006601	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
393130006602	active site
393130006603	substrate binding pocket [chemical binding]; other site
393130006604	homodimer interaction site [polypeptide binding]; other site
393130006605	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
393130006606	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
393130006607	active site
393130006608	P-loop; other site
393130006609	phosphorylation site [posttranslational modification]
393130006610	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130006611	active site
393130006612	phosphorylation site [posttranslational modification]
393130006613	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130006614	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130006615	DNA-binding site [nucleotide binding]; DNA binding site
393130006616	UTRA domain; Region: UTRA; pfam07702
393130006617	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
393130006618	active site
393130006619	DNA polymerase IV; Validated; Region: PRK02406
393130006620	DNA binding site [nucleotide binding]
393130006621	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
393130006622	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
393130006623	NAD(P) binding site [chemical binding]; other site
393130006624	active site
393130006625	ribonuclease Z; Region: RNase_Z; TIGR02651
393130006626	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
393130006627	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
393130006628	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
393130006629	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
393130006630	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
393130006631	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130006632	Coenzyme A binding pocket [chemical binding]; other site
393130006633	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
393130006634	6-phosphogluconate dehydratase; Region: edd; TIGR01196
393130006635	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710
393130006636	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393130006637	PYR/PP interface [polypeptide binding]; other site
393130006638	dimer interface [polypeptide binding]; other site
393130006639	TPP binding site [chemical binding]; other site
393130006640	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393130006641	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
393130006642	TPP-binding site [chemical binding]; other site
393130006643	dimer interface [polypeptide binding]; other site
393130006644	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
393130006645	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
393130006646	putative valine binding site [chemical binding]; other site
393130006647	dimer interface [polypeptide binding]; other site
393130006648	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
393130006649	ketol-acid reductoisomerase; Provisional; Region: PRK05479
393130006650	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
393130006651	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
393130006652	2-isopropylmalate synthase; Validated; Region: PRK00915
393130006653	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
393130006654	active site
393130006655	catalytic residues [active]
393130006656	metal binding site [ion binding]; metal-binding site
393130006657	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
393130006658	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
393130006659	tartrate dehydrogenase; Region: TTC; TIGR02089
393130006660	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
393130006661	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
393130006662	substrate binding site [chemical binding]; other site
393130006663	ligand binding site [chemical binding]; other site
393130006664	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
393130006665	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
393130006666	substrate binding site [chemical binding]; other site
393130006667	threonine dehydratase; Validated; Region: PRK08639
393130006668	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
393130006669	tetramer interface [polypeptide binding]; other site
393130006670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130006671	catalytic residue [active]
393130006672	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
393130006673	alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252
393130006674	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
393130006675	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
393130006676	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
393130006677	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
393130006678	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130006679	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130006680	DNA binding site [nucleotide binding]
393130006681	domain linker motif; other site
393130006682	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130006683	dimerization interface [polypeptide binding]; other site
393130006684	ligand binding site [chemical binding]; other site
393130006685	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
393130006686	intersubunit interface [polypeptide binding]; other site
393130006687	active site
393130006688	catalytic residue [active]
393130006689	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393130006690	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
393130006691	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393130006692	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
393130006693	active pocket/dimerization site; other site
393130006694	active site
393130006695	phosphorylation site [posttranslational modification]
393130006696	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393130006697	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
393130006698	putative active site [active]
393130006699	SIS domain; Region: SIS; pfam01380
393130006700	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
393130006701	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
393130006702	dimer interface [polypeptide binding]; other site
393130006703	active site
393130006704	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
393130006705	dimer interface [polypeptide binding]; other site
393130006706	active site
393130006707	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
393130006708	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
393130006709	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
393130006710	active site
393130006711	phosphorylation site [posttranslational modification]
393130006712	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130006713	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130006714	DNA-binding site [nucleotide binding]; DNA binding site
393130006715	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
393130006716	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130006717	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130006718	DNA-binding site [nucleotide binding]; DNA binding site
393130006719	UTRA domain; Region: UTRA; pfam07702
393130006720	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130006721	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130006722	active site
393130006723	catalytic tetrad [active]
393130006724	acetolactate synthase; Reviewed; Region: PRK08617
393130006725	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
393130006726	PYR/PP interface [polypeptide binding]; other site
393130006727	dimer interface [polypeptide binding]; other site
393130006728	TPP binding site [chemical binding]; other site
393130006729	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
393130006730	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
393130006731	TPP-binding site [chemical binding]; other site
393130006732	dimer interface [polypeptide binding]; other site
393130006733	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130006734	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
393130006735	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
393130006736	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130006737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130006738	dimer interface [polypeptide binding]; other site
393130006739	conserved gate region; other site
393130006740	ABC-ATPase subunit interface; other site
393130006741	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
393130006742	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130006743	dimer interface [polypeptide binding]; other site
393130006744	conserved gate region; other site
393130006745	ABC-ATPase subunit interface; other site
393130006746	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
393130006747	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130006748	active site
393130006749	phosphorylation site [posttranslational modification]
393130006750	intermolecular recognition site; other site
393130006751	dimerization interface [polypeptide binding]; other site
393130006752	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130006753	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
393130006754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130006755	dimerization interface [polypeptide binding]; other site
393130006756	Histidine kinase; Region: His_kinase; pfam06580
393130006757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130006758	ATP binding site [chemical binding]; other site
393130006759	Mg2+ binding site [ion binding]; other site
393130006760	G-X-G motif; other site
393130006761	Predicted integral membrane protein [Function unknown]; Region: COG5578
393130006762	Uncharacterized conserved protein [Function unknown]; Region: COG3538
393130006763	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
393130006764	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393130006765	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
393130006766	active site
393130006767	metal binding site [ion binding]; metal-binding site
393130006768	homodimer interface [polypeptide binding]; other site
393130006769	catalytic site [active]
393130006770	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393130006771	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
393130006772	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
393130006773	active site
393130006774	catalytic site [active]
393130006775	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
393130006776	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
393130006777	DNA-binding site [nucleotide binding]; DNA binding site
393130006778	RNA-binding motif; other site
393130006779	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
393130006780	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
393130006781	active site
393130006782	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
393130006783	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393130006784	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
393130006785	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
393130006786	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
393130006787	HIGH motif; other site
393130006788	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
393130006789	active site
393130006790	KMSKS motif; other site
393130006791	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
393130006792	tRNA binding surface [nucleotide binding]; other site
393130006793	anticodon binding site; other site
393130006794	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
393130006795	DivIVA protein; Region: DivIVA; pfam05103
393130006796	DivIVA domain; Region: DivI1A_domain; TIGR03544
393130006797	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
393130006798	HTH domain; Region: HTH_11; pfam08279
393130006799	3H domain; Region: 3H; pfam02829
393130006800	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
393130006801	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
393130006802	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130006803	catalytic residue [active]
393130006804	L-aspartate oxidase; Provisional; Region: PRK08071
393130006805	L-aspartate oxidase; Provisional; Region: PRK06175
393130006806	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
393130006807	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072
393130006808	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
393130006809	dimerization interface [polypeptide binding]; other site
393130006810	active site
393130006811	quinolinate synthetase; Provisional; Region: PRK09375
393130006812	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
393130006813	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130006814	RNA binding surface [nucleotide binding]; other site
393130006815	YGGT family; Region: YGGT; pfam02325
393130006816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
393130006817	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
393130006818	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
393130006819	catalytic residue [active]
393130006820	cell division protein FtsZ; Validated; Region: PRK09330
393130006821	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
393130006822	nucleotide binding site [chemical binding]; other site
393130006823	SulA interaction site; other site
393130006824	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
393130006825	Cell division protein FtsA; Region: FtsA; smart00842
393130006826	Cell division protein FtsA; Region: FtsA; pfam14450
393130006827	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
393130006828	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
393130006829	Cell division protein FtsQ; Region: FtsQ; pfam03799
393130006830	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
393130006831	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
393130006832	active site
393130006833	homodimer interface [polypeptide binding]; other site
393130006834	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
393130006835	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393130006836	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393130006837	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
393130006838	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
393130006839	Mg++ binding site [ion binding]; other site
393130006840	putative catalytic motif [active]
393130006841	putative substrate binding site [chemical binding]; other site
393130006842	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
393130006843	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
393130006844	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
393130006845	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
393130006846	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
393130006847	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
393130006848	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393130006849	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
393130006850	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
393130006851	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
393130006852	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
393130006853	MraW methylase family; Region: Methyltransf_5; pfam01795
393130006854	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
393130006855	MraZ protein; Region: MraZ; pfam02381
393130006856	MraZ protein; Region: MraZ; pfam02381
393130006857	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130006858	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130006859	putative substrate translocation pore; other site
393130006860	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
393130006861	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
393130006862	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
393130006863	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
393130006864	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
393130006865	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
393130006866	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
393130006867	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
393130006868	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
393130006869	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
393130006870	hypothetical protein; Provisional; Region: PRK13670
393130006871	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393130006872	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393130006873	ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119
393130006874	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130006875	Walker A/P-loop; other site
393130006876	ATP binding site [chemical binding]; other site
393130006877	Q-loop/lid; other site
393130006878	ABC transporter signature motif; other site
393130006879	Walker B; other site
393130006880	D-loop; other site
393130006881	H-loop/switch region; other site
393130006882	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
393130006883	PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986
393130006884	protein binding site [polypeptide binding]; other site
393130006885	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
393130006886	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
393130006887	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
393130006888	active site
393130006889	(T/H)XGH motif; other site
393130006890	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
393130006891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130006892	S-adenosylmethionine binding site [chemical binding]; other site
393130006893	hypothetical protein; Provisional; Region: PRK02886
393130006894	Regulatory protein involved in competence development and sporulation [Replication, recombination and repair;    Signal transduction mechanisms]; Region: COG3679
393130006895	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
393130006896	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
393130006897	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
393130006898	UbiA prenyltransferase family; Region: UbiA; pfam01040
393130006899	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
393130006900	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
393130006901	Ion transport protein; Region: Ion_trans; pfam00520
393130006902	Ion channel; Region: Ion_trans_2; pfam07885
393130006903	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
393130006904	MOSC domain; Region: MOSC; pfam03473
393130006905	3-alpha domain; Region: 3-alpha; pfam03475
393130006906	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
393130006907	Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372
393130006908	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
393130006909	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953
393130006910	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
393130006911	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
393130006912	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
393130006913	active site
393130006914	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
393130006915	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
393130006916	ring oligomerisation interface [polypeptide binding]; other site
393130006917	ATP/Mg binding site [chemical binding]; other site
393130006918	stacking interactions; other site
393130006919	hinge regions; other site
393130006920	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
393130006921	oligomerisation interface [polypeptide binding]; other site
393130006922	mobile loop; other site
393130006923	roof hairpin; other site
393130006924	CAAX protease self-immunity; Region: Abi; pfam02517
393130006925	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
393130006926	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
393130006927	CoA binding domain; Region: CoA_binding; pfam02629
393130006928	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393130006929	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130006930	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130006931	ABC transporter; Region: ABC_tran_2; pfam12848
393130006932	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130006933	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393130006934	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
393130006935	UGMP family protein; Validated; Region: PRK09604
393130006936	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
393130006937	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
393130006938	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130006939	Coenzyme A binding pocket [chemical binding]; other site
393130006940	Glycoprotease family; Region: Peptidase_M22; pfam00814
393130006941	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
393130006942	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
393130006943	camphor resistance protein CrcB; Provisional; Region: PRK14214
393130006944	camphor resistance protein CrcB; Provisional; Region: PRK14231
393130006945	Uncharacterized conserved protein [Function unknown]; Region: COG4832
393130006946	Phosphotransferase enzyme family; Region: APH; pfam01636
393130006947	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
393130006948	active site
393130006949	substrate binding site [chemical binding]; other site
393130006950	ATP binding site [chemical binding]; other site
393130006951	Cna protein B-type domain; Region: Cna_B; pfam05738
393130006952	Cna protein B-type domain; Region: Cna_B; pfam05738
393130006953	Cna protein B-type domain; Region: Cna_B; pfam05738
393130006954	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130006955	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130006956	non-specific DNA binding site [nucleotide binding]; other site
393130006957	salt bridge; other site
393130006958	sequence-specific DNA binding site [nucleotide binding]; other site
393130006959	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393130006960	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393130006961	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130006962	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130006963	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
393130006964	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
393130006965	substrate binding pocket [chemical binding]; other site
393130006966	argininosuccinate synthase; Provisional; Region: PRK13820
393130006967	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
393130006968	ANP binding site [chemical binding]; other site
393130006969	Substrate Binding Site II [chemical binding]; other site
393130006970	Substrate Binding Site I [chemical binding]; other site
393130006971	argininosuccinate lyase; Provisional; Region: PRK00855
393130006972	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
393130006973	active sites [active]
393130006974	tetramer interface [polypeptide binding]; other site
393130006975	BCCT family transporter; Region: BCCT; pfam02028
393130006976	hypothetical protein; Provisional; Region: PRK06357
393130006977	active site
393130006978	intersubunit interface [polypeptide binding]; other site
393130006979	Zn2+ binding site [ion binding]; other site
393130006980	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
393130006981	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
393130006982	putative substrate binding site [chemical binding]; other site
393130006983	putative ATP binding site [chemical binding]; other site
393130006984	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393130006985	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393130006986	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393130006987	active site
393130006988	P-loop; other site
393130006989	phosphorylation site [posttranslational modification]
393130006990	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130006991	active site
393130006992	phosphorylation site [posttranslational modification]
393130006993	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130006994	PRD domain; Region: PRD; pfam00874
393130006995	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130006996	active site
393130006997	P-loop; other site
393130006998	phosphorylation site [posttranslational modification]
393130006999	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
393130007000	active site
393130007001	phosphorylation site [posttranslational modification]
393130007002	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
393130007003	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130007004	DNA-binding site [nucleotide binding]; DNA binding site
393130007005	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130007006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130007007	homodimer interface [polypeptide binding]; other site
393130007008	catalytic residue [active]
393130007009	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
393130007010	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
393130007011	active site
393130007012	multimer interface [polypeptide binding]; other site
393130007013	imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188
393130007014	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
393130007015	predicted active site [active]
393130007016	catalytic triad [active]
393130007017	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
393130007018	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
393130007019	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
393130007020	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
393130007021	G1 box; other site
393130007022	GTP/Mg2+ binding site [chemical binding]; other site
393130007023	Switch I region; other site
393130007024	G2 box; other site
393130007025	G3 box; other site
393130007026	Switch II region; other site
393130007027	G4 box; other site
393130007028	G5 box; other site
393130007029	Nucleoside recognition; Region: Gate; pfam07670
393130007030	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
393130007031	Nucleoside recognition; Region: Gate; pfam07670
393130007032	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
393130007033	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
393130007034	putative active site [active]
393130007035	putative metal binding site [ion binding]; other site
393130007036	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130007037	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
393130007038	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130007039	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
393130007040	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
393130007041	active site
393130007042	dimer interface [polypeptide binding]; other site
393130007043	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393130007044	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
393130007045	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
393130007046	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
393130007047	dimer interface [polypeptide binding]; other site
393130007048	FMN binding site [chemical binding]; other site
393130007049	NADPH bind site [chemical binding]; other site
393130007050	Helix-turn-helix domain; Region: HTH_17; pfam12728
393130007051	putative heme peroxidase; Provisional; Region: PRK12276
393130007052	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130007053	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130007054	Walker A/P-loop; other site
393130007055	ATP binding site [chemical binding]; other site
393130007056	Q-loop/lid; other site
393130007057	ABC transporter signature motif; other site
393130007058	Walker B; other site
393130007059	D-loop; other site
393130007060	H-loop/switch region; other site
393130007061	FtsX-like permease family; Region: FtsX; pfam02687
393130007062	FtsX-like permease family; Region: FtsX; pfam02687
393130007063	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130007064	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130007065	Coenzyme A binding pocket [chemical binding]; other site
393130007066	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
393130007067	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
393130007068	active site
393130007069	substrate binding site [chemical binding]; other site
393130007070	metal binding site [ion binding]; metal-binding site
393130007071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
393130007072	YbbR-like protein; Region: YbbR; pfam07949
393130007073	YbbR-like protein; Region: YbbR; pfam07949
393130007074	YbbR-like protein; Region: YbbR; pfam07949
393130007075	Uncharacterized conserved protein [Function unknown]; Region: COG1624
393130007076	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
393130007077	maltose phosphorylase; Provisional; Region: PRK13807
393130007078	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
393130007079	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
393130007080	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
393130007081	Predicted integral membrane protein [Function unknown]; Region: COG5521
393130007082	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130007083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007084	dimer interface [polypeptide binding]; other site
393130007085	conserved gate region; other site
393130007086	putative PBP binding loops; other site
393130007087	ABC-ATPase subunit interface; other site
393130007088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007089	dimer interface [polypeptide binding]; other site
393130007090	conserved gate region; other site
393130007091	putative PBP binding loops; other site
393130007092	ABC-ATPase subunit interface; other site
393130007093	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
393130007094	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130007095	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
393130007096	homodimer interface [polypeptide binding]; other site
393130007097	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
393130007098	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
393130007099	active site
393130007100	homodimer interface [polypeptide binding]; other site
393130007101	catalytic site [active]
393130007102	CAAX protease self-immunity; Region: Abi; cl00558
393130007103	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130007104	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130007105	DNA binding site [nucleotide binding]
393130007106	domain linker motif; other site
393130007107	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
393130007108	ligand binding site [chemical binding]; other site
393130007109	dimerization interface [polypeptide binding]; other site
393130007110	Amino acid permease; Region: AA_permease_2; pfam13520
393130007111	K+ potassium transporter; Region: K_trans; cl15781
393130007112	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130007113	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130007114	ligand binding site [chemical binding]; other site
393130007115	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130007116	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
393130007117	ligand binding site [chemical binding]; other site
393130007118	flexible hinge region; other site
393130007119	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130007120	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393130007121	intersubunit interface [polypeptide binding]; other site
393130007122	active site
393130007123	zinc binding site [ion binding]; other site
393130007124	Na+ binding site [ion binding]; other site
393130007125	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393130007126	intersubunit interface [polypeptide binding]; other site
393130007127	active site
393130007128	zinc binding site [ion binding]; other site
393130007129	Na+ binding site [ion binding]; other site
393130007130	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130007131	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130007132	active site
393130007133	P-loop; other site
393130007134	phosphorylation site [posttranslational modification]
393130007135	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130007136	active site
393130007137	phosphorylation site [posttranslational modification]
393130007138	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130007139	HTH domain; Region: HTH_11; pfam08279
393130007140	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130007141	PRD domain; Region: PRD; pfam00874
393130007142	PRD domain; Region: PRD; pfam00874
393130007143	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130007144	active site
393130007145	P-loop; other site
393130007146	phosphorylation site [posttranslational modification]
393130007147	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
393130007148	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130007149	Walker A/P-loop; other site
393130007150	ATP binding site [chemical binding]; other site
393130007151	Q-loop/lid; other site
393130007152	ABC transporter signature motif; other site
393130007153	Walker B; other site
393130007154	D-loop; other site
393130007155	H-loop/switch region; other site
393130007156	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
393130007157	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
393130007158	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
393130007159	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130007160	Coenzyme A binding pocket [chemical binding]; other site
393130007161	Transcriptional regulators [Transcription]; Region: GntR; COG1802
393130007162	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
393130007163	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
393130007164	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
393130007165	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130007166	DNA-binding site [nucleotide binding]; DNA binding site
393130007167	UTRA domain; Region: UTRA; pfam07702
393130007168	Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641
393130007169	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
393130007170	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130007171	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130007172	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
393130007173	putative dimerization interface [polypeptide binding]; other site
393130007174	Predicted membrane protein [Function unknown]; Region: COG2855
393130007175	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
393130007176	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
393130007177	putative metal binding site [ion binding]; other site
393130007178	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
393130007179	homodimer interface [polypeptide binding]; other site
393130007180	chemical substrate binding site [chemical binding]; other site
393130007181	oligomer interface [polypeptide binding]; other site
393130007182	metal binding site [ion binding]; metal-binding site
393130007183	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130007184	catalytic residues [active]
393130007185	flavodoxin; Provisional; Region: PRK09271
393130007186	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
393130007187	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
393130007188	dimer interface [polypeptide binding]; other site
393130007189	putative radical transfer pathway; other site
393130007190	diiron center [ion binding]; other site
393130007191	tyrosyl radical; other site
393130007192	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209
393130007193	Class I ribonucleotide reductase; Region: RNR_I; cd01679
393130007194	active site
393130007195	dimer interface [polypeptide binding]; other site
393130007196	catalytic residues [active]
393130007197	effector binding site; other site
393130007198	R2 peptide binding site; other site
393130007199	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
393130007200	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
393130007201	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
393130007202	CsbD-like; Region: CsbD; cl17424
393130007203	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130007204	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130007205	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393130007206	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393130007207	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
393130007208	DNA interaction; other site
393130007209	Metal-binding active site; metal-binding site
393130007210	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
393130007211	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
393130007212	conserved cys residue [active]
393130007213	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393130007214	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130007215	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130007216	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
393130007217	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393130007218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130007219	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130007220	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
393130007221	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130007222	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130007223	ligand binding site [chemical binding]; other site
393130007224	flexible hinge region; other site
393130007225	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
393130007226	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
393130007227	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130007228	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
393130007229	dimer interface [polypeptide binding]; other site
393130007230	active site
393130007231	metal binding site [ion binding]; metal-binding site
393130007232	glutathione binding site [chemical binding]; other site
393130007233	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
393130007234	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
393130007235	FMN binding site [chemical binding]; other site
393130007236	substrate binding site [chemical binding]; other site
393130007237	putative catalytic residue [active]
393130007238	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
393130007239	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
393130007240	putative substrate translocation pore; other site
393130007241	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
393130007242	Coenzyme A transferase; Region: CoA_trans; smart00882
393130007243	Coenzyme A transferase; Region: CoA_trans; cl17247
393130007244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130007245	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
393130007246	Walker A motif; other site
393130007247	ATP binding site [chemical binding]; other site
393130007248	Walker B motif; other site
393130007249	arginine finger; other site
393130007250	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
393130007251	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
393130007252	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
393130007253	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
393130007254	metal binding site [ion binding]; metal-binding site
393130007255	active site
393130007256	I-site; other site
393130007257	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
393130007258	classical (c) SDRs; Region: SDR_c; cd05233
393130007259	NAD(P) binding site [chemical binding]; other site
393130007260	active site
393130007261	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130007262	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130007263	Tic20-like protein; Region: Tic20; pfam09685
393130007264	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393130007265	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007266	Collagen binding domain; Region: Collagen_bind; pfam05737
393130007267	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007268	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007269	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007270	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007271	Cna protein B-type domain; Region: Cna_B; pfam05738
393130007272	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007273	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007274	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007275	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130007276	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
393130007277	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
393130007278	active site
393130007279	catalytic site [active]
393130007280	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393130007281	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393130007282	Walker A/P-loop; other site
393130007283	ATP binding site [chemical binding]; other site
393130007284	Q-loop/lid; other site
393130007285	ABC transporter signature motif; other site
393130007286	Walker B; other site
393130007287	D-loop; other site
393130007288	H-loop/switch region; other site
393130007289	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393130007290	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130007291	ABC-ATPase subunit  interface; other site
393130007292	dimer interface [polypeptide binding]; other site
393130007293	putative PBP binding regions; other site
393130007294	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
393130007295	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
393130007296	putative ligand binding residues [chemical binding]; other site
393130007297	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393130007298	heme-binding site [chemical binding]; other site
393130007299	Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386
393130007300	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393130007301	heme-binding site [chemical binding]; other site
393130007302	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393130007303	heme-binding site [chemical binding]; other site
393130007304	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
393130007305	heme uptake protein IsdC; Region: IsdC; TIGR03656
393130007306	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
393130007307	heme-binding site [chemical binding]; other site
393130007308	sortase B cell surface sorting signal; Region: srtB_target; TIGR03063
393130007309	Protein of unknown function (DUF3116); Region: DUF3116; pfam11313
393130007310	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
393130007311	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
393130007312	active site
393130007313	Zn binding site [ion binding]; other site
393130007314	Competence protein CoiA-like family; Region: CoiA; cl11541
393130007315	Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862
393130007316	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
393130007317	ArsC family; Region: ArsC; pfam03960
393130007318	putative catalytic residues [active]
393130007319	thiol/disulfide switch; other site
393130007320	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
393130007321	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
393130007322	Walker A/P-loop; other site
393130007323	ATP binding site [chemical binding]; other site
393130007324	Q-loop/lid; other site
393130007325	ABC transporter signature motif; other site
393130007326	Walker B; other site
393130007327	D-loop; other site
393130007328	H-loop/switch region; other site
393130007329	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
393130007330	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
393130007331	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
393130007332	Walker A/P-loop; other site
393130007333	ATP binding site [chemical binding]; other site
393130007334	Q-loop/lid; other site
393130007335	ABC transporter signature motif; other site
393130007336	Walker B; other site
393130007337	D-loop; other site
393130007338	H-loop/switch region; other site
393130007339	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
393130007340	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
393130007341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007342	dimer interface [polypeptide binding]; other site
393130007343	conserved gate region; other site
393130007344	putative PBP binding loops; other site
393130007345	ABC-ATPase subunit interface; other site
393130007346	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
393130007347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007348	dimer interface [polypeptide binding]; other site
393130007349	conserved gate region; other site
393130007350	putative PBP binding loops; other site
393130007351	ABC-ATPase subunit interface; other site
393130007352	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393130007353	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393130007354	peptide binding site [polypeptide binding]; other site
393130007355	Domain of unknown function (DUF3899); Region: DUF3899; pfam13038
393130007356	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
393130007357	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
393130007358	active site
393130007359	HIGH motif; other site
393130007360	dimer interface [polypeptide binding]; other site
393130007361	KMSKS motif; other site
393130007362	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
393130007363	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130007364	MarR family; Region: MarR; pfam01047
393130007365	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
393130007366	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
393130007367	dimer interface [polypeptide binding]; other site
393130007368	active site
393130007369	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
393130007370	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
393130007371	dimer interface [polypeptide binding]; other site
393130007372	active site
393130007373	CoA binding pocket [chemical binding]; other site
393130007374	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130007375	SH3-like domain; Region: SH3_8; pfam13457
393130007376	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
393130007377	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130007378	catalytic core [active]
393130007379	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
393130007380	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
393130007381	Clp amino terminal domain; Region: Clp_N; pfam02861
393130007382	Clp amino terminal domain; Region: Clp_N; pfam02861
393130007383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130007384	Walker A motif; other site
393130007385	ATP binding site [chemical binding]; other site
393130007386	Walker B motif; other site
393130007387	arginine finger; other site
393130007388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130007389	Walker A motif; other site
393130007390	ATP binding site [chemical binding]; other site
393130007391	Walker B motif; other site
393130007392	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
393130007393	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
393130007394	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
393130007395	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130007396	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007397	active site
393130007398	motif I; other site
393130007399	motif II; other site
393130007400	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393130007401	Predicted acetyltransferase [General function prediction only]; Region: COG3393
393130007402	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
393130007403	ferrochelatase; Provisional; Region: PRK12435
393130007404	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
393130007405	C-terminal domain interface [polypeptide binding]; other site
393130007406	active site
393130007407	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
393130007408	active site
393130007409	N-terminal domain interface [polypeptide binding]; other site
393130007410	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
393130007411	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
393130007412	substrate binding site [chemical binding]; other site
393130007413	active site
393130007414	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
393130007415	Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473
393130007416	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393130007417	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130007418	Walker A/P-loop; other site
393130007419	ATP binding site [chemical binding]; other site
393130007420	Q-loop/lid; other site
393130007421	ABC transporter signature motif; other site
393130007422	Walker B; other site
393130007423	D-loop; other site
393130007424	H-loop/switch region; other site
393130007425	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
393130007426	HIT family signature motif; other site
393130007427	catalytic residue [active]
393130007428	Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980
393130007429	Protein of unknown function (DUF3267); Region: DUF3267; pfam11667
393130007430	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
393130007431	SurA N-terminal domain; Region: SurA_N_3; cl07813
393130007432	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
393130007433	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
393130007434	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
393130007435	generic binding surface II; other site
393130007436	generic binding surface I; other site
393130007437	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130007438	Zn2+ binding site [ion binding]; other site
393130007439	Mg2+ binding site [ion binding]; other site
393130007440	Uncharacterized conserved protein [Function unknown]; Region: COG4717
393130007441	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
393130007442	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
393130007443	active site
393130007444	metal binding site [ion binding]; metal-binding site
393130007445	DNA binding site [nucleotide binding]
393130007446	hypothetical protein; Provisional; Region: PRK13676
393130007447	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
393130007448	fumarate hydratase; Reviewed; Region: fumC; PRK00485
393130007449	Class II fumarases; Region: Fumarase_classII; cd01362
393130007450	active site
393130007451	tetramer interface [polypeptide binding]; other site
393130007452	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
393130007453	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130007454	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130007455	Walker A/P-loop; other site
393130007456	ATP binding site [chemical binding]; other site
393130007457	Q-loop/lid; other site
393130007458	ABC transporter signature motif; other site
393130007459	Walker B; other site
393130007460	D-loop; other site
393130007461	H-loop/switch region; other site
393130007462	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
393130007463	Transglycosylase; Region: Transgly; pfam00912
393130007464	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
393130007465	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
393130007466	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393130007467	Low molecular weight phosphatase family; Region: LMWPc; cl00105
393130007468	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393130007469	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
393130007470	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393130007471	Domain of unknown function DUF21; Region: DUF21; pfam01595
393130007472	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393130007473	Transporter associated domain; Region: CorC_HlyC; smart01091
393130007474	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130007475	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130007476	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
393130007477	putative dimerization interface [polypeptide binding]; other site
393130007478	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
393130007479	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
393130007480	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
393130007481	active site
393130007482	FMN binding site [chemical binding]; other site
393130007483	substrate binding site [chemical binding]; other site
393130007484	putative catalytic residue [active]
393130007485	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130007486	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130007487	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
393130007488	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
393130007489	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
393130007490	shikimate binding site; other site
393130007491	NAD(P) binding site [chemical binding]; other site
393130007492	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130007493	putative substrate translocation pore; other site
393130007494	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130007495	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130007496	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130007497	putative substrate translocation pore; other site
393130007498	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
393130007499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130007500	Walker A/P-loop; other site
393130007501	ATP binding site [chemical binding]; other site
393130007502	Q-loop/lid; other site
393130007503	ABC transporter signature motif; other site
393130007504	Walker B; other site
393130007505	D-loop; other site
393130007506	H-loop/switch region; other site
393130007507	Predicted transcriptional regulators [Transcription]; Region: COG1725
393130007508	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
393130007509	DNA-binding site [nucleotide binding]; DNA binding site
393130007510	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
393130007511	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
393130007512	DNA binding site [nucleotide binding]
393130007513	active site
393130007514	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
393130007515	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
393130007516	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130007517	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130007518	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
393130007519	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
393130007520	active site
393130007521	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
393130007522	putative dimer interface [polypeptide binding]; other site
393130007523	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130007524	ligand binding site [chemical binding]; other site
393130007525	Zn binding site [ion binding]; other site
393130007526	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
393130007527	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
393130007528	active site
393130007529	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130007530	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130007531	active site
393130007532	catalytic tetrad [active]
393130007533	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
393130007534	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
393130007535	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393130007536	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393130007537	substrate binding pocket [chemical binding]; other site
393130007538	membrane-bound complex binding site; other site
393130007539	hinge residues; other site
393130007540	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393130007541	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007542	dimer interface [polypeptide binding]; other site
393130007543	conserved gate region; other site
393130007544	putative PBP binding loops; other site
393130007545	ABC-ATPase subunit interface; other site
393130007546	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393130007547	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393130007548	Walker A/P-loop; other site
393130007549	ATP binding site [chemical binding]; other site
393130007550	Q-loop/lid; other site
393130007551	ABC transporter signature motif; other site
393130007552	Walker B; other site
393130007553	D-loop; other site
393130007554	H-loop/switch region; other site
393130007555	aspartate aminotransferase; Provisional; Region: PRK06348
393130007556	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130007557	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130007558	homodimer interface [polypeptide binding]; other site
393130007559	catalytic residue [active]
393130007560	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
393130007561	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393130007562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007563	motif II; other site
393130007564	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
393130007565	intracellular protease, PfpI family; Region: PfpI; TIGR01382
393130007566	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
393130007567	proposed catalytic triad [active]
393130007568	conserved cys residue [active]
393130007569	basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576
393130007570	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130007571	methionine cluster; other site
393130007572	active site
393130007573	phosphorylation site [posttranslational modification]
393130007574	metal binding site [ion binding]; metal-binding site
393130007575	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
393130007576	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130007577	Coenzyme A binding pocket [chemical binding]; other site
393130007578	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
393130007579	esterase; Provisional; Region: PRK10566
393130007580	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
393130007581	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130007582	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
393130007583	motif II; other site
393130007584	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007585	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393130007586	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130007587	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130007588	hypothetical protein; Provisional; Region: PRK13673
393130007589	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
393130007590	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
393130007591	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
393130007592	Part of AAA domain; Region: AAA_19; pfam13245
393130007593	Family description; Region: UvrD_C_2; pfam13538
393130007594	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
393130007595	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
393130007596	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
393130007597	IDEAL domain; Region: IDEAL; pfam08858
393130007598	ComK protein; Region: ComK; cl11560
393130007599	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
393130007600	AP2 domain; Region: AP2; pfam00847
393130007601	Domain of unknown function (DUF3825); Region: DUF3825; pfam12873
393130007602	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
393130007603	Domain of unknown function (DUF3597); Region: DUF3597; pfam12200
393130007604	Phage holin; Region: Phage_holin_5; pfam06946
393130007605	Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669
393130007606	Domain of unknown function (DUF2479); Region: DUF2479; pfam10651
393130007607	Prophage endopeptidase tail; Region: Prophage_tail; pfam06605
393130007608	Phage tail protein; Region: Sipho_tail; pfam05709
393130007609	tape measure domain; Region: tape_meas_nterm; TIGR02675
393130007610	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
393130007611	Phage protein Gp14; Region: Phage_Gp14; pfam10666
393130007612	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
393130007613	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
393130007614	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
393130007615	Minor capsid protein; Region: Minor_capsid_2; pfam11114
393130007616	Minor capsid protein; Region: Minor_capsid_1; pfam10665
393130007617	Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053
393130007618	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
393130007619	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
393130007620	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
393130007621	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
393130007622	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
393130007623	Phage terminase large subunit; Region: Terminase_3; cl12054
393130007624	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
393130007625	DNA binding residues [nucleotide binding]
393130007626	Terminase small subunit; Region: Terminase_2; pfam03592
393130007627	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
393130007628	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
393130007629	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393130007630	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393130007631	dimer interface [polypeptide binding]; other site
393130007632	ssDNA binding site [nucleotide binding]; other site
393130007633	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130007634	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
393130007635	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393130007636	phage uncharacterized protein TIGR01671; Region: phage_TIGR01671
393130007637	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
393130007638	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
393130007639	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
393130007640	cofactor binding site; other site
393130007641	DNA binding site [nucleotide binding]
393130007642	substrate interaction site [chemical binding]; other site
393130007643	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
393130007644	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
393130007645	AntA/AntB antirepressor; Region: AntA; pfam08346
393130007646	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
393130007647	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130007648	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130007649	non-specific DNA binding site [nucleotide binding]; other site
393130007650	salt bridge; other site
393130007651	sequence-specific DNA binding site [nucleotide binding]; other site
393130007652	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130007653	non-specific DNA binding site [nucleotide binding]; other site
393130007654	salt bridge; other site
393130007655	sequence-specific DNA binding site [nucleotide binding]; other site
393130007656	Putative zinc-finger; Region: zf-HC2; pfam13490
393130007657	Domain of unknown function (DUF955); Region: DUF955; pfam06114
393130007658	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
393130007659	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
393130007660	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
393130007661	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
393130007662	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
393130007663	catalytic residues [active]
393130007664	catalytic nucleophile [active]
393130007665	Presynaptic Site I dimer interface [polypeptide binding]; other site
393130007666	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
393130007667	Synaptic Flat tetramer interface [polypeptide binding]; other site
393130007668	Synaptic Site I dimer interface [polypeptide binding]; other site
393130007669	DNA binding site [nucleotide binding]
393130007670	Recombinase; Region: Recombinase; pfam07508
393130007671	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
393130007672	ComK protein; Region: ComK; cl11560
393130007673	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130007674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130007675	non-specific DNA binding site [nucleotide binding]; other site
393130007676	salt bridge; other site
393130007677	sequence-specific DNA binding site [nucleotide binding]; other site
393130007678	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
393130007679	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130007680	active site
393130007681	phosphorylation site [posttranslational modification]
393130007682	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130007683	active site
393130007684	P-loop; other site
393130007685	phosphorylation site [posttranslational modification]
393130007686	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130007687	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
393130007688	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
393130007689	putative substrate binding site [chemical binding]; other site
393130007690	putative ATP binding site [chemical binding]; other site
393130007691	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130007692	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393130007693	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130007694	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
393130007695	trimer interface [polypeptide binding]; other site
393130007696	active site
393130007697	G bulge; other site
393130007698	Uncharacterized conserved protein [Function unknown]; Region: COG1683
393130007699	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
393130007700	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
393130007701	non-specific DNA interactions [nucleotide binding]; other site
393130007702	DNA binding site [nucleotide binding]
393130007703	sequence specific DNA binding site [nucleotide binding]; other site
393130007704	putative cAMP binding site [chemical binding]; other site
393130007705	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
393130007706	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
393130007707	substrate binding site [chemical binding]; other site
393130007708	ATP binding site [chemical binding]; other site
393130007709	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
393130007710	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
393130007711	RNA binding surface [nucleotide binding]; other site
393130007712	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
393130007713	active site
393130007714	uracil binding [chemical binding]; other site
393130007715	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
393130007716	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
393130007717	active site
393130007718	non-prolyl cis peptide bond; other site
393130007719	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
393130007720	catalytic residues [active]
393130007721	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
393130007722	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
393130007723	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
393130007724	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
393130007725	Walker A/P-loop; other site
393130007726	ATP binding site [chemical binding]; other site
393130007727	Q-loop/lid; other site
393130007728	ABC transporter signature motif; other site
393130007729	Walker B; other site
393130007730	D-loop; other site
393130007731	H-loop/switch region; other site
393130007732	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393130007733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007734	dimer interface [polypeptide binding]; other site
393130007735	conserved gate region; other site
393130007736	putative PBP binding loops; other site
393130007737	ABC-ATPase subunit interface; other site
393130007738	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
393130007739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007740	dimer interface [polypeptide binding]; other site
393130007741	conserved gate region; other site
393130007742	putative PBP binding loops; other site
393130007743	ABC-ATPase subunit interface; other site
393130007744	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
393130007745	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
393130007746	substrate binding pocket [chemical binding]; other site
393130007747	membrane-bound complex binding site; other site
393130007748	hinge residues; other site
393130007749	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130007750	Coenzyme A binding pocket [chemical binding]; other site
393130007751	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
393130007752	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
393130007753	Transcriptional regulator [Transcription]; Region: LysR; COG0583
393130007754	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
393130007755	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
393130007756	dimerization interface [polypeptide binding]; other site
393130007757	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
393130007758	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
393130007759	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
393130007760	active site
393130007761	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130007762	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130007763	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130007764	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130007765	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
393130007766	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393130007767	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393130007768	active site
393130007769	trimer interface [polypeptide binding]; other site
393130007770	allosteric site; other site
393130007771	active site lid [active]
393130007772	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393130007773	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130007774	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007775	active site
393130007776	motif I; other site
393130007777	motif II; other site
393130007778	Predicted membrane protein [Function unknown]; Region: COG1511
393130007779	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
393130007780	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
393130007781	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
393130007782	Predicted transcriptional regulator [Transcription]; Region: COG1959
393130007783	Transcriptional regulator; Region: Rrf2; pfam02082
393130007784	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
393130007785	L-tyrosine decarboxylase; Provisional; Region: PRK13520
393130007786	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
393130007787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130007788	catalytic residue [active]
393130007789	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
393130007790	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130007791	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
393130007792	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
393130007793	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
393130007794	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
393130007795	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
393130007796	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
393130007797	active site
393130007798	dimer interface [polypeptide binding]; other site
393130007799	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
393130007800	dimer interface [polypeptide binding]; other site
393130007801	active site
393130007802	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
393130007803	nudix motif; other site
393130007804	general stress protein 13; Validated; Region: PRK08059
393130007805	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
393130007806	RNA binding site [nucleotide binding]; other site
393130007807	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
393130007808	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
393130007809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130007810	homodimer interface [polypeptide binding]; other site
393130007811	catalytic residue [active]
393130007812	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
393130007813	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130007814	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130007815	Walker A/P-loop; other site
393130007816	ATP binding site [chemical binding]; other site
393130007817	Q-loop/lid; other site
393130007818	ABC transporter signature motif; other site
393130007819	Walker B; other site
393130007820	D-loop; other site
393130007821	H-loop/switch region; other site
393130007822	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130007823	active site
393130007824	P-loop; other site
393130007825	phosphorylation site [posttranslational modification]
393130007826	aspartate kinase; Reviewed; Region: PRK09034
393130007827	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
393130007828	putative catalytic residues [active]
393130007829	putative nucleotide binding site [chemical binding]; other site
393130007830	putative aspartate binding site [chemical binding]; other site
393130007831	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
393130007832	allosteric regulatory residue; other site
393130007833	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
393130007834	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
393130007835	active site
393130007836	drug efflux system protein MdtG; Provisional; Region: PRK09874
393130007837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130007838	putative substrate translocation pore; other site
393130007839	monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645
393130007840	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
393130007841	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
393130007842	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
393130007843	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600
393130007844	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
393130007845	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
393130007846	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
393130007847	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600
393130007848	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585
393130007849	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
393130007850	CoenzymeA binding site [chemical binding]; other site
393130007851	subunit interaction site [polypeptide binding]; other site
393130007852	PHB binding site; other site
393130007853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963
393130007854	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
393130007855	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
393130007856	Cl- selectivity filter; other site
393130007857	Cl- binding residues [ion binding]; other site
393130007858	pore gating glutamate residue; other site
393130007859	dimer interface [polypeptide binding]; other site
393130007860	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878
393130007861	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
393130007862	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130007863	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
393130007864	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130007865	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130007866	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
393130007867	NADH(P)-binding; Region: NAD_binding_10; pfam13460
393130007868	NAD(P) binding site [chemical binding]; other site
393130007869	putative active site [active]
393130007870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844
393130007871	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837
393130007872	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130007873	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007874	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007875	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007876	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007877	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007878	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007879	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130007880	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
393130007881	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
393130007882	tetramer interfaces [polypeptide binding]; other site
393130007883	binuclear metal-binding site [ion binding]; other site
393130007884	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393130007885	Domain of unknown function DUF21; Region: DUF21; pfam01595
393130007886	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393130007887	Transporter associated domain; Region: CorC_HlyC; smart01091
393130007888	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
393130007889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130007890	Coenzyme A binding pocket [chemical binding]; other site
393130007891	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
393130007892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007893	active site
393130007894	motif I; other site
393130007895	motif II; other site
393130007896	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130007897	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
393130007898	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
393130007899	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
393130007900	active site
393130007901	metal binding site [ion binding]; metal-binding site
393130007902	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
393130007903	Predicted permeases [General function prediction only]; Region: COG0730
393130007904	Predicted membrane protein [Function unknown]; Region: COG4272
393130007905	Uncharacterized conserved protein [Function unknown]; Region: COG1801
393130007906	Superfamily II helicase [General function prediction only]; Region: COG1204
393130007907	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130007908	ATP binding site [chemical binding]; other site
393130007909	putative Mg++ binding site [ion binding]; other site
393130007910	nucleotide binding region [chemical binding]; other site
393130007911	helicase superfamily c-terminal domain; Region: HELICc; smart00490
393130007912	ATP-binding site [chemical binding]; other site
393130007913	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
393130007914	AAA ATPase domain; Region: AAA_15; pfam13175
393130007915	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130007916	Walker A/P-loop; other site
393130007917	ATP binding site [chemical binding]; other site
393130007918	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
393130007919	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
393130007920	putative active site [active]
393130007921	putative metal-binding site [ion binding]; other site
393130007922	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
393130007923	Part of AAA domain; Region: AAA_19; pfam13245
393130007924	Family description; Region: UvrD_C_2; pfam13538
393130007925	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
393130007926	FeS assembly protein SufB; Region: sufB; TIGR01980
393130007927	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
393130007928	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
393130007929	trimerization site [polypeptide binding]; other site
393130007930	active site
393130007931	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
393130007932	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
393130007933	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130007934	catalytic residue [active]
393130007935	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
393130007936	FeS assembly protein SufD; Region: sufD; TIGR01981
393130007937	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
393130007938	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
393130007939	Walker A/P-loop; other site
393130007940	ATP binding site [chemical binding]; other site
393130007941	Q-loop/lid; other site
393130007942	ABC transporter signature motif; other site
393130007943	Walker B; other site
393130007944	D-loop; other site
393130007945	H-loop/switch region; other site
393130007946	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
393130007947	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
393130007948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130007949	ABC-ATPase subunit interface; other site
393130007950	putative PBP binding loops; other site
393130007951	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
393130007952	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
393130007953	Walker A/P-loop; other site
393130007954	ATP binding site [chemical binding]; other site
393130007955	Q-loop/lid; other site
393130007956	ABC transporter signature motif; other site
393130007957	Walker B; other site
393130007958	D-loop; other site
393130007959	H-loop/switch region; other site
393130007960	NIL domain; Region: NIL; pfam09383
393130007961	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130007962	dimer interface [polypeptide binding]; other site
393130007963	phosphorylation site [posttranslational modification]
393130007964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130007965	ATP binding site [chemical binding]; other site
393130007966	Mg2+ binding site [ion binding]; other site
393130007967	G-X-G motif; other site
393130007968	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130007969	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130007970	active site
393130007971	phosphorylation site [posttranslational modification]
393130007972	intermolecular recognition site; other site
393130007973	dimerization interface [polypeptide binding]; other site
393130007974	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130007975	DNA binding site [nucleotide binding]
393130007976	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393130007977	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
393130007978	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130007979	catalytic residues [active]
393130007980	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
393130007981	lipoyl attachment site [posttranslational modification]; other site
393130007982	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
393130007983	ArsC family; Region: ArsC; pfam03960
393130007984	putative ArsC-like catalytic residues; other site
393130007985	putative TRX-like catalytic residues [active]
393130007986	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
393130007987	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
393130007988	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
393130007989	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
393130007990	Walker A/P-loop; other site
393130007991	ATP binding site [chemical binding]; other site
393130007992	Q-loop/lid; other site
393130007993	ABC transporter signature motif; other site
393130007994	Walker B; other site
393130007995	D-loop; other site
393130007996	H-loop/switch region; other site
393130007997	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
393130007998	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
393130007999	ABC-ATPase subunit  interface; other site
393130008000	dimer interface [polypeptide binding]; other site
393130008001	putative PBP binding regions; other site
393130008002	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
393130008003	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
393130008004	intersubunit interface [polypeptide binding]; other site
393130008005	Predicted esterase [General function prediction only]; Region: COG0627
393130008006	S-formylglutathione hydrolase; Region: PLN02442
393130008007	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
393130008008	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130008009	catalytic residue [active]
393130008010	SdpI/YhfL protein family; Region: SdpI; pfam13630
393130008011	CAT RNA binding domain; Region: CAT_RBD; smart01061
393130008012	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393130008013	PRD domain; Region: PRD; pfam00874
393130008014	PRD domain; Region: PRD; pfam00874
393130008015	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
393130008016	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
393130008017	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
393130008018	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
393130008019	Predicted transcriptional regulator [Transcription]; Region: COG2378
393130008020	HTH domain; Region: HTH_11; pfam08279
393130008021	WYL domain; Region: WYL; pfam13280
393130008022	Uncharacterized conserved protein [Function unknown]; Region: COG1434
393130008023	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
393130008024	putative active site [active]
393130008025	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393130008026	Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055
393130008027	active site
393130008028	catalytic site [active]
393130008029	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393130008030	putative metal binding site [ion binding]; other site
393130008031	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393130008032	putative metal binding site [ion binding]; other site
393130008033	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130008034	Leucine rich repeat; Region: LRR_8; pfam13855
393130008035	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
393130008036	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
393130008037	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
393130008038	active site
393130008039	catalytic site [active]
393130008040	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
393130008041	putative metal binding site [ion binding]; other site
393130008042	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
393130008043	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130008044	non-specific DNA binding site [nucleotide binding]; other site
393130008045	salt bridge; other site
393130008046	sequence-specific DNA binding site [nucleotide binding]; other site
393130008047	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
393130008048	Tetratricopeptide repeat; Region: TPR_12; pfam13424
393130008049	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
393130008050	SmpB-tmRNA interface; other site
393130008051	ribonuclease R; Region: RNase_R; TIGR02063
393130008052	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
393130008053	RNB domain; Region: RNB; pfam00773
393130008054	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
393130008055	RNA binding site [nucleotide binding]; other site
393130008056	Esterase/lipase [General function prediction only]; Region: COG1647
393130008057	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393130008058	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
393130008059	Preprotein translocase SecG subunit; Region: SecG; cl09123
393130008060	Esterase/lipase [General function prediction only]; Region: COG1647
393130008061	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
393130008062	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
393130008063	PGAP1-like protein; Region: PGAP1; pfam07819
393130008064	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
393130008065	enolase; Provisional; Region: eno; PRK00077
393130008066	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
393130008067	dimer interface [polypeptide binding]; other site
393130008068	metal binding site [ion binding]; metal-binding site
393130008069	substrate binding pocket [chemical binding]; other site
393130008070	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
393130008071	phosphoglyceromutase; Provisional; Region: PRK05434
393130008072	triosephosphate isomerase; Provisional; Region: PRK14567
393130008073	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
393130008074	substrate binding site [chemical binding]; other site
393130008075	dimer interface [polypeptide binding]; other site
393130008076	catalytic triad [active]
393130008077	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
393130008078	Phosphoglycerate kinase; Region: PGK; pfam00162
393130008079	substrate binding site [chemical binding]; other site
393130008080	hinge regions; other site
393130008081	ADP binding site [chemical binding]; other site
393130008082	catalytic site [active]
393130008083	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
393130008084	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
393130008085	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
393130008086	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
393130008087	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
393130008088	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
393130008089	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
393130008090	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
393130008091	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130008092	DNA binding site [nucleotide binding]
393130008093	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
393130008094	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
393130008095	active site
393130008096	dimer interface [polypeptide binding]; other site
393130008097	MMPL family; Region: MMPL; pfam03176
393130008098	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
393130008099	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130008100	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130008101	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
393130008102	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397
393130008103	Chitin binding domain; Region: Chitin_bind_3; pfam03067
393130008104	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
393130008105	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
393130008106	Interdomain contacts; other site
393130008107	Cytokine receptor motif; other site
393130008108	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393130008109	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393130008110	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
393130008111	aromatic chitin/cellulose binding site residues [chemical binding]; other site
393130008112	Clp protease; Region: CLP_protease; pfam00574
393130008113	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
393130008114	oligomer interface [polypeptide binding]; other site
393130008115	active site residues [active]
393130008116	amino acid transporter; Region: 2A0306; TIGR00909
393130008117	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
393130008118	Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354
393130008119	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130008120	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130008121	Substrate binding site [chemical binding]; other site
393130008122	Leucine rich repeat; Region: LRR_8; pfam13855
393130008123	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
393130008124	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
393130008125	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
393130008126	active site
393130008127	FMN binding site [chemical binding]; other site
393130008128	substrate binding site [chemical binding]; other site
393130008129	homotetramer interface [polypeptide binding]; other site
393130008130	catalytic residue [active]
393130008131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
393130008132	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
393130008133	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
393130008134	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
393130008135	phosphate binding site [ion binding]; other site
393130008136	putative substrate binding pocket [chemical binding]; other site
393130008137	dimer interface [polypeptide binding]; other site
393130008138	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
393130008139	AAA domain; Region: AAA_18; pfam13238
393130008140	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
393130008141	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
393130008142	active site
393130008143	substrate binding site [chemical binding]; other site
393130008144	metal binding site [ion binding]; metal-binding site
393130008145	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
393130008146	active site
393130008147	catalytic residues [active]
393130008148	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
393130008149	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
393130008150	NAD binding site [chemical binding]; other site
393130008151	homodimer interface [polypeptide binding]; other site
393130008152	active site
393130008153	substrate binding site [chemical binding]; other site
393130008154	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
393130008155	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
393130008156	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130008157	TPR repeat; Region: TPR_11; pfam13414
393130008158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130008159	binding surface
393130008160	TPR motif; other site
393130008161	Tetratricopeptide repeat; Region: TPR_12; pfam13424
393130008162	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
393130008163	binding surface
393130008164	TPR motif; other site
393130008165	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
393130008166	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
393130008167	putative trimer interface [polypeptide binding]; other site
393130008168	putative CoA binding site [chemical binding]; other site
393130008169	pyrophosphatase PpaX; Provisional; Region: PRK13288
393130008170	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393130008171	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130008172	motif II; other site
393130008173	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
393130008174	HPr kinase/phosphorylase; Provisional; Region: PRK05428
393130008175	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
393130008176	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
393130008177	Hpr binding site; other site
393130008178	active site
393130008179	homohexamer subunit interaction site [polypeptide binding]; other site
393130008180	Predicted membrane protein [Function unknown]; Region: COG1950
393130008181	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
393130008182	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
393130008183	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393130008184	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393130008185	Uncharacterized conserved protein [Function unknown]; Region: COG3595
393130008186	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
393130008187	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
393130008188	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393130008189	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
393130008190	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
393130008191	excinuclease ABC subunit B; Provisional; Region: PRK05298
393130008192	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130008193	ATP binding site [chemical binding]; other site
393130008194	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130008195	nucleotide binding region [chemical binding]; other site
393130008196	ATP-binding site [chemical binding]; other site
393130008197	Ultra-violet resistance protein B; Region: UvrB; pfam12344
393130008198	UvrB/uvrC motif; Region: UVR; pfam02151
393130008199	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897
393130008200	HD containing hydrolase-like enzyme; Region: HD_2; pfam12917
393130008201	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
393130008202	dimerization interface [polypeptide binding]; other site
393130008203	putative DNA binding site [nucleotide binding]; other site
393130008204	putative Zn2+ binding site [ion binding]; other site
393130008205	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
393130008206	PhoU domain; Region: PhoU; pfam01895
393130008207	PhoU domain; Region: PhoU; pfam01895
393130008208	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
393130008209	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
393130008210	Walker A/P-loop; other site
393130008211	ATP binding site [chemical binding]; other site
393130008212	Q-loop/lid; other site
393130008213	ABC transporter signature motif; other site
393130008214	Walker B; other site
393130008215	D-loop; other site
393130008216	H-loop/switch region; other site
393130008217	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
393130008218	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
393130008219	Walker A/P-loop; other site
393130008220	ATP binding site [chemical binding]; other site
393130008221	Q-loop/lid; other site
393130008222	ABC transporter signature motif; other site
393130008223	Walker B; other site
393130008224	D-loop; other site
393130008225	H-loop/switch region; other site
393130008226	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
393130008227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130008228	dimer interface [polypeptide binding]; other site
393130008229	conserved gate region; other site
393130008230	putative PBP binding loops; other site
393130008231	ABC-ATPase subunit interface; other site
393130008232	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
393130008233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130008234	dimer interface [polypeptide binding]; other site
393130008235	conserved gate region; other site
393130008236	putative PBP binding loops; other site
393130008237	ABC-ATPase subunit interface; other site
393130008238	PBP superfamily domain; Region: PBP_like_2; cl17296
393130008239	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
393130008240	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
393130008241	HAMP domain; Region: HAMP; pfam00672
393130008242	dimerization interface [polypeptide binding]; other site
393130008243	PAS domain; Region: PAS; smart00091
393130008244	putative active site [active]
393130008245	heme pocket [chemical binding]; other site
393130008246	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130008247	dimer interface [polypeptide binding]; other site
393130008248	phosphorylation site [posttranslational modification]
393130008249	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130008250	ATP binding site [chemical binding]; other site
393130008251	Mg2+ binding site [ion binding]; other site
393130008252	G-X-G motif; other site
393130008253	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130008254	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130008255	active site
393130008256	phosphorylation site [posttranslational modification]
393130008257	intermolecular recognition site; other site
393130008258	dimerization interface [polypeptide binding]; other site
393130008259	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130008260	DNA binding site [nucleotide binding]
393130008261	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
393130008262	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
393130008263	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
393130008264	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
393130008265	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
393130008266	putative active site [active]
393130008267	catalytic site [active]
393130008268	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
393130008269	putative active site [active]
393130008270	catalytic site [active]
393130008271	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
393130008272	Peptidase family M23; Region: Peptidase_M23; pfam01551
393130008273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
393130008274	NlpC/P60 family; Region: NLPC_P60; pfam00877
393130008275	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
393130008276	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
393130008277	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
393130008278	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130008279	Walker A/P-loop; other site
393130008280	ATP binding site [chemical binding]; other site
393130008281	Q-loop/lid; other site
393130008282	ABC transporter signature motif; other site
393130008283	Walker B; other site
393130008284	D-loop; other site
393130008285	H-loop/switch region; other site
393130008286	Uncharacterized conserved protein [Function unknown]; Region: COG1284
393130008287	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130008288	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
393130008289	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
393130008290	peptide chain release factor 2; Validated; Region: prfB; PRK00578
393130008291	This domain is found in peptide chain release factors; Region: PCRF; smart00937
393130008292	RF-1 domain; Region: RF-1; pfam00472
393130008293	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
393130008294	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
393130008295	nucleotide binding region [chemical binding]; other site
393130008296	helicase superfamily c-terminal domain; Region: HELICc; smart00490
393130008297	ATP-binding site [chemical binding]; other site
393130008298	SEC-C motif; Region: SEC-C; pfam02810
393130008299	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
393130008300	30S subunit binding site; other site
393130008301	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
393130008302	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130008303	active site
393130008304	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
393130008305	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130008306	ATP binding site [chemical binding]; other site
393130008307	putative Mg++ binding site [ion binding]; other site
393130008308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130008309	nucleotide binding region [chemical binding]; other site
393130008310	ATP-binding site [chemical binding]; other site
393130008311	EDD domain protein, DegV family; Region: DegV; TIGR00762
393130008312	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
393130008313	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
393130008314	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130008315	active site
393130008316	phosphorylation site [posttranslational modification]
393130008317	intermolecular recognition site; other site
393130008318	dimerization interface [polypeptide binding]; other site
393130008319	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
393130008320	DNA binding residues [nucleotide binding]
393130008321	dimerization interface [polypeptide binding]; other site
393130008322	Uncharacterized conserved protein [Function unknown]; Region: COG1739
393130008323	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
393130008324	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
393130008325	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
393130008326	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
393130008327	Transcriptional regulator [Transcription]; Region: LytR; COG1316
393130008328	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
393130008329	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
393130008330	Mg++ binding site [ion binding]; other site
393130008331	putative catalytic motif [active]
393130008332	substrate binding site [chemical binding]; other site
393130008333	N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317
393130008334	o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928
393130008335	active site
393130008336	octamer interface [polypeptide binding]; other site
393130008337	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
393130008338	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
393130008339	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008340	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
393130008342	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393130008343	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393130008344	dimer interface [polypeptide binding]; other site
393130008345	ssDNA binding site [nucleotide binding]; other site
393130008346	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130008347	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
393130008348	rod shape-determining protein Mbl; Provisional; Region: PRK13928
393130008349	MreB and similar proteins; Region: MreB_like; cd10225
393130008350	nucleotide binding site [chemical binding]; other site
393130008351	Mg binding site [ion binding]; other site
393130008352	putative protofilament interaction site [polypeptide binding]; other site
393130008353	RodZ interaction site [polypeptide binding]; other site
393130008354	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
393130008355	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
393130008356	hinge; other site
393130008357	active site
393130008358	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
393130008359	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
393130008360	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
393130008361	gamma subunit interface [polypeptide binding]; other site
393130008362	epsilon subunit interface [polypeptide binding]; other site
393130008363	LBP interface [polypeptide binding]; other site
393130008364	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
393130008365	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393130008366	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
393130008367	alpha subunit interaction interface [polypeptide binding]; other site
393130008368	Walker A motif; other site
393130008369	ATP binding site [chemical binding]; other site
393130008370	Walker B motif; other site
393130008371	inhibitor binding site; inhibition site
393130008372	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393130008373	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
393130008374	core domain interface [polypeptide binding]; other site
393130008375	delta subunit interface [polypeptide binding]; other site
393130008376	epsilon subunit interface [polypeptide binding]; other site
393130008377	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
393130008378	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
393130008379	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
393130008380	beta subunit interaction interface [polypeptide binding]; other site
393130008381	Walker A motif; other site
393130008382	ATP binding site [chemical binding]; other site
393130008383	Walker B motif; other site
393130008384	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
393130008385	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
393130008386	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
393130008387	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
393130008388	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
393130008389	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
393130008390	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
393130008391	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
393130008392	ATP synthase I chain; Region: ATP_synt_I; pfam03899
393130008393	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
393130008394	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
393130008395	active site
393130008396	homodimer interface [polypeptide binding]; other site
393130008397	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
393130008398	active site
393130008399	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
393130008400	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
393130008401	dimer interface [polypeptide binding]; other site
393130008402	active site
393130008403	glycine-pyridoxal phosphate binding site [chemical binding]; other site
393130008404	folate binding site [chemical binding]; other site
393130008405	Low molecular weight phosphatase family; Region: LMWPc; cd00115
393130008406	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
393130008407	active site
393130008408	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
393130008409	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
393130008410	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
393130008411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130008412	S-adenosylmethionine binding site [chemical binding]; other site
393130008413	peptide chain release factor 1; Validated; Region: prfA; PRK00591
393130008414	This domain is found in peptide chain release factors; Region: PCRF; smart00937
393130008415	RF-1 domain; Region: RF-1; pfam00472
393130008416	thymidine kinase; Provisional; Region: PRK04296
393130008417	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
393130008418	ATP binding site [chemical binding]; other site
393130008419	Walker A motif; other site
393130008420	Walker B motif; other site
393130008421	homoserine kinase; Provisional; Region: PRK01212
393130008422	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
393130008423	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
393130008424	threonine synthase; Reviewed; Region: PRK06721
393130008425	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
393130008426	homodimer interface [polypeptide binding]; other site
393130008427	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130008428	catalytic residue [active]
393130008429	homoserine dehydrogenase; Provisional; Region: PRK06349
393130008430	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
393130008431	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
393130008432	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
393130008433	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
393130008434	Predicted membrane protein [Function unknown]; Region: COG2246
393130008435	GtrA-like protein; Region: GtrA; pfam04138
393130008436	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
393130008437	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
393130008438	Ligand binding site; other site
393130008439	Putative Catalytic site; other site
393130008440	DXD motif; other site
393130008441	transcription termination factor Rho; Provisional; Region: rho; PRK09376
393130008442	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
393130008443	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
393130008444	RNA binding site [nucleotide binding]; other site
393130008445	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
393130008446	multimer interface [polypeptide binding]; other site
393130008447	Walker A motif; other site
393130008448	ATP binding site [chemical binding]; other site
393130008449	Walker B motif; other site
393130008450	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
393130008451	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
393130008452	hinge; other site
393130008453	active site
393130008454	Predicted integral membrane protein [Function unknown]; Region: COG0392
393130008455	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
393130008456	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
393130008457	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
393130008458	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
393130008459	putative ADP-binding pocket [chemical binding]; other site
393130008460	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
393130008461	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
393130008462	intersubunit interface [polypeptide binding]; other site
393130008463	active site
393130008464	zinc binding site [ion binding]; other site
393130008465	Na+ binding site [ion binding]; other site
393130008466	putative lipid kinase; Reviewed; Region: PRK13055
393130008467	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
393130008468	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632
393130008469	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
393130008470	amidase catalytic site [active]
393130008471	Zn binding residues [ion binding]; other site
393130008472	substrate binding site [chemical binding]; other site
393130008473	SH3-like domain; Region: SH3_8; pfam13457
393130008474	SH3-like domain; Region: SH3_8; pfam13457
393130008475	SH3-like domain; Region: SH3_8; pfam13457
393130008476	SH3-like domain; Region: SH3_8; pfam13457
393130008477	CTP synthetase; Validated; Region: pyrG; PRK05380
393130008478	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
393130008479	Catalytic site [active]
393130008480	active site
393130008481	UTP binding site [chemical binding]; other site
393130008482	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
393130008483	active site
393130008484	putative oxyanion hole; other site
393130008485	catalytic triad [active]
393130008486	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
393130008487	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
393130008488	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
393130008489	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
393130008490	active site
393130008491	HIGH motif; other site
393130008492	KMSK motif region; other site
393130008493	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
393130008494	tRNA binding surface [nucleotide binding]; other site
393130008495	anticodon binding site; other site
393130008496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506
393130008497	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
393130008498	Peptidase family M50; Region: Peptidase_M50; pfam02163
393130008499	active site
393130008500	putative substrate binding region [chemical binding]; other site
393130008501	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
393130008502	active site 1 [active]
393130008503	dimer interface [polypeptide binding]; other site
393130008504	hexamer interface [polypeptide binding]; other site
393130008505	active site 2 [active]
393130008506	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
393130008507	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130008508	Zn2+ binding site [ion binding]; other site
393130008509	Mg2+ binding site [ion binding]; other site
393130008510	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
393130008511	conserved hypothetical protein TIGR01655; Region: yxeA_fam
393130008512	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
393130008513	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
393130008514	peptide binding site [polypeptide binding]; other site
393130008515	Predicted integral membrane protein [Function unknown]; Region: COG5658
393130008516	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
393130008517	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
393130008518	catalytic triad [active]
393130008519	metal binding site [ion binding]; metal-binding site
393130008520	conserved cis-peptide bond; other site
393130008521	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
393130008522	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
393130008523	folate binding site [chemical binding]; other site
393130008524	NADP+ binding site [chemical binding]; other site
393130008525	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
393130008526	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
393130008527	putative NAD(P) binding site [chemical binding]; other site
393130008528	dimer interface [polypeptide binding]; other site
393130008529	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
393130008530	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
393130008531	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
393130008532	Collagen binding domain; Region: Collagen_bind; pfam05737
393130008533	Collagen binding domain; Region: Collagen_bind; pfam05737
393130008534	Collagen binding domain; Region: Collagen_bind; pfam05737
393130008535	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008536	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008537	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008538	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008539	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008540	Cna protein B-type domain; Region: Cna_B; pfam05738
393130008541	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130008542	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130008543	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130008544	active site
393130008545	motif I; other site
393130008546	motif II; other site
393130008547	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
393130008548	Uncharacterized conserved protein [Function unknown]; Region: COG1359
393130008549	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
393130008550	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
393130008551	Walker A/P-loop; other site
393130008552	ATP binding site [chemical binding]; other site
393130008553	Q-loop/lid; other site
393130008554	ABC transporter signature motif; other site
393130008555	Walker B; other site
393130008556	D-loop; other site
393130008557	H-loop/switch region; other site
393130008558	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
393130008559	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
393130008560	FtsX-like permease family; Region: FtsX; pfam02687
393130008561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
393130008562	dimerization interface [polypeptide binding]; other site
393130008563	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130008564	dimer interface [polypeptide binding]; other site
393130008565	phosphorylation site [posttranslational modification]
393130008566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130008567	ATP binding site [chemical binding]; other site
393130008568	Mg2+ binding site [ion binding]; other site
393130008569	G-X-G motif; other site
393130008570	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130008571	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130008572	active site
393130008573	phosphorylation site [posttranslational modification]
393130008574	intermolecular recognition site; other site
393130008575	dimerization interface [polypeptide binding]; other site
393130008576	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130008577	DNA binding site [nucleotide binding]
393130008578	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
393130008579	Uncharacterized conserved protein [Function unknown]; Region: COG2427
393130008580	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
393130008581	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
393130008582	catalytic loop [active]
393130008583	iron binding site [ion binding]; other site
393130008584	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
393130008585	4Fe-4S binding domain; Region: Fer4; pfam00037
393130008586	4Fe-4S binding domain; Region: Fer4; pfam00037
393130008587	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
393130008588	[4Fe-4S] binding site [ion binding]; other site
393130008589	molybdopterin cofactor binding site; other site
393130008590	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
393130008591	molybdopterin cofactor binding site; other site
393130008592	Uncharacterized conserved protein [Function unknown]; Region: COG1912
393130008593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130008594	putative substrate translocation pore; other site
393130008595	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130008596	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130008597	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130008598	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
393130008599	non-specific DNA binding site [nucleotide binding]; other site
393130008600	salt bridge; other site
393130008601	sequence-specific DNA binding site [nucleotide binding]; other site
393130008602	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
393130008603	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
393130008604	Bacteriophage holin; Region: Phage_holin_1; pfam04531
393130008605	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
393130008606	Phage tail protein; Region: Sipho_tail; cl17486
393130008607	Phage-related tail protein [Function unknown]; Region: COG5283
393130008608	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
393130008609	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
393130008610	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
393130008611	Phage terminase large subunit; Region: Terminase_3; cl12054
393130008612	Terminase-like family; Region: Terminase_6; pfam03237
393130008613	Uncharacterized conserved protein [Function unknown]; Region: COG5484
393130008614	Phage terminase small subunit; Region: Phage_terminase; pfam10668
393130008615	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
393130008616	Protein of unknown function (DUF2481); Region: DUF2481; pfam10654
393130008617	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
393130008618	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
393130008619	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
393130008620	dimer interface [polypeptide binding]; other site
393130008621	ssDNA binding site [nucleotide binding]; other site
393130008622	tetramer (dimer of dimers) interface [polypeptide binding]; other site
393130008623	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
393130008624	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393130008625	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
393130008626	YopX protein; Region: YopX; pfam09643
393130008627	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
393130008628	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
393130008629	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
393130008630	RecT family; Region: RecT; pfam03837
393130008631	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130008632	AAA domain; Region: AAA_23; pfam13476
393130008633	Walker A/P-loop; other site
393130008634	ATP binding site [chemical binding]; other site
393130008635	Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653
393130008636	Helix-turn-helix domain; Region: HTH_17; pfam12728
393130008637	AntA/AntB antirepressor; Region: AntA; pfam08346
393130008638	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
393130008639	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130008640	non-specific DNA binding site [nucleotide binding]; other site
393130008641	salt bridge; other site
393130008642	sequence-specific DNA binding site [nucleotide binding]; other site
393130008643	transcriptional repressor DicA; Reviewed; Region: PRK09706
393130008644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130008645	non-specific DNA binding site [nucleotide binding]; other site
393130008646	salt bridge; other site
393130008647	sequence-specific DNA binding site [nucleotide binding]; other site
393130008648	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
393130008649	Domain of unknown function (DUF955); Region: DUF955; cl01076
393130008650	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
393130008651	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
393130008652	Int/Topo IB signature motif; other site
393130008653	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
393130008654	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
393130008655	Walker A motif; other site
393130008656	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130008657	SH3-like domain; Region: SH3_8; pfam13457
393130008658	SH3-like domain; Region: SH3_8; pfam13457
393130008659	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130008660	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130008661	active site
393130008662	catalytic tetrad [active]
393130008663	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130008664	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130008665	DNA binding residues [nucleotide binding]
393130008666	putative dimer interface [polypeptide binding]; other site
393130008667	CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913
393130008668	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
393130008669	tetramer interface [polypeptide binding]; other site
393130008670	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
393130008671	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
393130008672	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
393130008673	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
393130008674	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
393130008675	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
393130008676	23S rRNA interface [nucleotide binding]; other site
393130008677	L3 interface [polypeptide binding]; other site
393130008678	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
393130008679	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
393130008680	dimerization interface 3.5A [polypeptide binding]; other site
393130008681	active site
393130008682	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
393130008683	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
393130008684	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393130008685	Walker A/P-loop; other site
393130008686	ATP binding site [chemical binding]; other site
393130008687	Q-loop/lid; other site
393130008688	ABC transporter signature motif; other site
393130008689	Walker B; other site
393130008690	D-loop; other site
393130008691	H-loop/switch region; other site
393130008692	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
393130008693	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
393130008694	Walker A/P-loop; other site
393130008695	ATP binding site [chemical binding]; other site
393130008696	Q-loop/lid; other site
393130008697	ABC transporter signature motif; other site
393130008698	Walker B; other site
393130008699	D-loop; other site
393130008700	H-loop/switch region; other site
393130008701	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
393130008702	MgtC family; Region: MgtC; pfam02308
393130008703	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
393130008704	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
393130008705	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
393130008706	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
393130008707	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
393130008708	alphaNTD - beta interaction site [polypeptide binding]; other site
393130008709	alphaNTD homodimer interface [polypeptide binding]; other site
393130008710	alphaNTD - beta' interaction site [polypeptide binding]; other site
393130008711	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
393130008712	30S ribosomal protein S11; Validated; Region: PRK05309
393130008713	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
393130008714	30S ribosomal protein S13; Region: bact_S13; TIGR03631
393130008715	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
393130008716	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
393130008717	rRNA binding site [nucleotide binding]; other site
393130008718	predicted 30S ribosome binding site; other site
393130008719	adenylate kinase; Reviewed; Region: adk; PRK00279
393130008720	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
393130008721	AMP-binding site [chemical binding]; other site
393130008722	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
393130008723	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
393130008724	SecY translocase; Region: SecY; pfam00344
393130008725	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
393130008726	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
393130008727	23S rRNA binding site [nucleotide binding]; other site
393130008728	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
393130008729	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
393130008730	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
393130008731	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
393130008732	5S rRNA interface [nucleotide binding]; other site
393130008733	L27 interface [polypeptide binding]; other site
393130008734	23S rRNA interface [nucleotide binding]; other site
393130008735	L5 interface [polypeptide binding]; other site
393130008736	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
393130008737	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
393130008738	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
393130008739	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
393130008740	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
393130008741	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
393130008742	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
393130008743	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
393130008744	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
393130008745	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
393130008746	RNA binding site [nucleotide binding]; other site
393130008747	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
393130008748	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
393130008749	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
393130008750	23S rRNA interface [nucleotide binding]; other site
393130008751	putative translocon interaction site; other site
393130008752	signal recognition particle (SRP54) interaction site; other site
393130008753	L23 interface [polypeptide binding]; other site
393130008754	trigger factor interaction site; other site
393130008755	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
393130008756	23S rRNA interface [nucleotide binding]; other site
393130008757	5S rRNA interface [nucleotide binding]; other site
393130008758	putative antibiotic binding site [chemical binding]; other site
393130008759	L25 interface [polypeptide binding]; other site
393130008760	L27 interface [polypeptide binding]; other site
393130008761	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
393130008762	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
393130008763	G-X-X-G motif; other site
393130008764	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
393130008765	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
393130008766	putative translocon binding site; other site
393130008767	protein-rRNA interface [nucleotide binding]; other site
393130008768	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
393130008769	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
393130008770	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
393130008771	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
393130008772	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
393130008773	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
393130008774	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
393130008775	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
393130008776	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
393130008777	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387
393130008778	UbiA prenyltransferase family; Region: UbiA; pfam01040
393130008779	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
393130008780	ApbE family; Region: ApbE; pfam02424
393130008781	Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939
393130008782	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
393130008783	This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900
393130008784	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
393130008785	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
393130008786	Predicted membrane protein [Function unknown]; Region: COG2259
393130008787	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
393130008788	trimer interface [polypeptide binding]; other site
393130008789	Predicted membrane protein [Function unknown]; Region: COG4769
393130008790	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
393130008791	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
393130008792	substrate binding pocket [chemical binding]; other site
393130008793	chain length determination region; other site
393130008794	substrate-Mg2+ binding site; other site
393130008795	catalytic residues [active]
393130008796	aspartate-rich region 1; other site
393130008797	active site lid residues [active]
393130008798	aspartate-rich region 2; other site
393130008799	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
393130008800	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
393130008801	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
393130008802	active site
393130008803	metal binding site [ion binding]; metal-binding site
393130008804	Protein of unknown function (DUF4003); Region: DUF4003; pfam13170
393130008805	SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860
393130008806	hypothetical protein; Provisional; Region: PRK02947
393130008807	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130008808	putative active site [active]
393130008809	Protein of unknown function (DUF1341); Region: DUF1341; cl06211
393130008810	Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402
393130008811	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
393130008812	active site
393130008813	substrate binding pocket [chemical binding]; other site
393130008814	homodimer interaction site [polypeptide binding]; other site
393130008815	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
393130008816	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
393130008817	active site
393130008818	P-loop; other site
393130008819	phosphorylation site [posttranslational modification]
393130008820	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130008821	active site
393130008822	phosphorylation site [posttranslational modification]
393130008823	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130008824	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130008825	PRD domain; Region: PRD; pfam00874
393130008826	PRD domain; Region: PRD; pfam00874
393130008827	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130008828	active site
393130008829	P-loop; other site
393130008830	phosphorylation site [posttranslational modification]
393130008831	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130008832	active site
393130008833	phosphorylation site [posttranslational modification]
393130008834	elongation factor Tu; Reviewed; Region: PRK00049
393130008835	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
393130008836	G1 box; other site
393130008837	GEF interaction site [polypeptide binding]; other site
393130008838	GTP/Mg2+ binding site [chemical binding]; other site
393130008839	Switch I region; other site
393130008840	G2 box; other site
393130008841	G3 box; other site
393130008842	Switch II region; other site
393130008843	G4 box; other site
393130008844	G5 box; other site
393130008845	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
393130008846	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
393130008847	Antibiotic Binding Site [chemical binding]; other site
393130008848	elongation factor G; Reviewed; Region: PRK00007
393130008849	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
393130008850	G1 box; other site
393130008851	putative GEF interaction site [polypeptide binding]; other site
393130008852	GTP/Mg2+ binding site [chemical binding]; other site
393130008853	Switch I region; other site
393130008854	G2 box; other site
393130008855	G3 box; other site
393130008856	Switch II region; other site
393130008857	G4 box; other site
393130008858	G5 box; other site
393130008859	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
393130008860	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
393130008861	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
393130008862	30S ribosomal protein S7; Validated; Region: PRK05302
393130008863	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
393130008864	S17 interaction site [polypeptide binding]; other site
393130008865	S8 interaction site; other site
393130008866	16S rRNA interaction site [nucleotide binding]; other site
393130008867	streptomycin interaction site [chemical binding]; other site
393130008868	23S rRNA interaction site [nucleotide binding]; other site
393130008869	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
393130008870	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
393130008871	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130008872	Zn2+ binding site [ion binding]; other site
393130008873	Mg2+ binding site [ion binding]; other site
393130008874	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
393130008875	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
393130008876	Zn2+ binding site [ion binding]; other site
393130008877	Mg2+ binding site [ion binding]; other site
393130008878	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
393130008879	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130008880	Coenzyme A binding pocket [chemical binding]; other site
393130008881	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130008882	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130008883	substrate binding site [chemical binding]; other site
393130008884	hexamer interface [polypeptide binding]; other site
393130008885	metal binding site [ion binding]; metal-binding site
393130008886	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
393130008887	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
393130008888	TPP-binding site [chemical binding]; other site
393130008889	dimer interface [polypeptide binding]; other site
393130008890	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
393130008891	PYR/PP interface [polypeptide binding]; other site
393130008892	dimer interface [polypeptide binding]; other site
393130008893	TPP binding site [chemical binding]; other site
393130008894	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
393130008895	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
393130008896	substrate binding site [chemical binding]; other site
393130008897	hexamer interface [polypeptide binding]; other site
393130008898	metal binding site [ion binding]; metal-binding site
393130008899	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
393130008900	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393130008901	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
393130008902	putative NAD(P) binding site [chemical binding]; other site
393130008903	catalytic Zn binding site [ion binding]; other site
393130008904	structural Zn binding site [ion binding]; other site
393130008905	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393130008906	NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236
393130008907	putative NAD(P) binding site [chemical binding]; other site
393130008908	catalytic Zn binding site [ion binding]; other site
393130008909	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
393130008910	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
393130008911	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
393130008912	active site
393130008913	P-loop; other site
393130008914	phosphorylation site [posttranslational modification]
393130008915	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130008916	active site
393130008917	phosphorylation site [posttranslational modification]
393130008918	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130008919	PRD domain; Region: PRD; pfam00874
393130008920	PRD domain; Region: PRD; pfam00874
393130008921	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130008922	active site
393130008923	P-loop; other site
393130008924	phosphorylation site [posttranslational modification]
393130008925	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130008926	active site
393130008927	phosphorylation site [posttranslational modification]
393130008928	Predicted membrane protein [Function unknown]; Region: COG4905
393130008929	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
393130008930	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
393130008931	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
393130008932	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
393130008933	active site
393130008934	Helix-turn-helix domain; Region: HTH_18; pfam12833
393130008935	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
393130008936	Ligand Binding Site [chemical binding]; other site
393130008937	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
393130008938	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
393130008939	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
393130008940	active site
393130008941	DNA binding site [nucleotide binding]
393130008942	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
393130008943	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
393130008944	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
393130008945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
393130008946	active site
393130008947	phosphorylation site [posttranslational modification]
393130008948	intermolecular recognition site; other site
393130008949	dimerization interface [polypeptide binding]; other site
393130008950	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
393130008951	DNA binding site [nucleotide binding]
393130008952	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
393130008953	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
393130008954	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
393130008955	Ligand Binding Site [chemical binding]; other site
393130008956	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
393130008957	GAF domain; Region: GAF_3; pfam13492
393130008958	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
393130008959	dimer interface [polypeptide binding]; other site
393130008960	phosphorylation site [posttranslational modification]
393130008961	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
393130008962	ATP binding site [chemical binding]; other site
393130008963	Mg2+ binding site [ion binding]; other site
393130008964	G-X-G motif; other site
393130008965	K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156
393130008966	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
393130008967	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130008968	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
393130008969	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130008970	active site
393130008971	P-loop; other site
393130008972	phosphorylation site [posttranslational modification]
393130008973	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130008974	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130008975	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130008976	methionine cluster; other site
393130008977	active site
393130008978	phosphorylation site [posttranslational modification]
393130008979	metal binding site [ion binding]; metal-binding site
393130008980	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393130008981	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
393130008982	magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524
393130008983	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
393130008984	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
393130008985	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
393130008986	Soluble P-type ATPase [General function prediction only]; Region: COG4087
393130008987	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
393130008988	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130008989	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130008990	autolysin; Reviewed; Region: PRK06347
393130008991	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
393130008992	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008993	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008994	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008995	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
393130008996	Protein of unknown function (DUF970); Region: DUF970; pfam06153
393130008997	thymidylate kinase; Validated; Region: tmk; PRK00698
393130008998	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
393130008999	TMP-binding site; other site
393130009000	ATP-binding site [chemical binding]; other site
393130009001	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
393130009002	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
393130009003	homodimer interface [polypeptide binding]; other site
393130009004	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130009005	catalytic residue [active]
393130009006	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
393130009007	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
393130009008	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393130009009	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
393130009010	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
393130009011	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
393130009012	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130009013	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130009014	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130009015	putative active site [active]
393130009016	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
393130009017	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130009018	active site
393130009019	motif I; other site
393130009020	motif II; other site
393130009021	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393130009022	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
393130009023	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
393130009024	active site
393130009025	catalytic tetrad [active]
393130009026	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
393130009027	recombination protein RecR; Reviewed; Region: recR; PRK00076
393130009028	RecR protein; Region: RecR; pfam02132
393130009029	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
393130009030	putative active site [active]
393130009031	putative metal-binding site [ion binding]; other site
393130009032	tetramer interface [polypeptide binding]; other site
393130009033	hypothetical protein; Validated; Region: PRK00153
393130009034	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
393130009035	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
393130009036	Walker A motif; other site
393130009037	ATP binding site [chemical binding]; other site
393130009038	Walker B motif; other site
393130009039	arginine finger; other site
393130009040	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
393130009041	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
393130009042	Protein of unknown function (DUF3188); Region: DUF3188; pfam11384
393130009043	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130009044	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130009045	Domain of unknown function (DUF4307); Region: DUF4307; pfam14155
393130009046	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
393130009047	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
393130009048	N- and C-terminal domain interface [polypeptide binding]; other site
393130009049	active site
393130009050	catalytic site [active]
393130009051	metal binding site [ion binding]; metal-binding site
393130009052	carbohydrate binding site [chemical binding]; other site
393130009053	ATP binding site [chemical binding]; other site
393130009054	SH3-like domain; Region: SH3_8; pfam13457
393130009055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
393130009056	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
393130009057	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130009058	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
393130009059	Walker A/P-loop; other site
393130009060	ATP binding site [chemical binding]; other site
393130009061	Q-loop/lid; other site
393130009062	ABC transporter signature motif; other site
393130009063	Walker B; other site
393130009064	D-loop; other site
393130009065	H-loop/switch region; other site
393130009066	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
393130009067	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130009068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130009069	Walker A/P-loop; other site
393130009070	ATP binding site [chemical binding]; other site
393130009071	Q-loop/lid; other site
393130009072	ABC transporter signature motif; other site
393130009073	Walker B; other site
393130009074	D-loop; other site
393130009075	H-loop/switch region; other site
393130009076	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
393130009077	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
393130009078	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
393130009079	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
393130009080	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
393130009081	nucleoside/Zn binding site; other site
393130009082	dimer interface [polypeptide binding]; other site
393130009083	catalytic motif [active]
393130009084	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
393130009085	Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972
393130009086	active site
393130009087	acyl-activating enzyme (AAE) consensus motif; other site
393130009088	putative CoA binding site [chemical binding]; other site
393130009089	AMP binding site [chemical binding]; other site
393130009090	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
393130009091	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
393130009092	active site
393130009093	trimer interface [polypeptide binding]; other site
393130009094	allosteric site; other site
393130009095	active site lid [active]
393130009096	hexamer (dimer of trimers) interface [polypeptide binding]; other site
393130009097	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
393130009098	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
393130009099	DNA binding residues [nucleotide binding]
393130009100	drug binding residues [chemical binding]; other site
393130009101	dimer interface [polypeptide binding]; other site
393130009102	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
393130009103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130009104	Coenzyme A binding pocket [chemical binding]; other site
393130009105	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
393130009106	dimer interface [polypeptide binding]; other site
393130009107	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
393130009108	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
393130009109	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
393130009110	MarR family; Region: MarR; pfam01047
393130009111	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
393130009112	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
393130009113	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
393130009114	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
393130009115	DNA binding residues [nucleotide binding]
393130009116	putative dimer interface [polypeptide binding]; other site
393130009117	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
393130009118	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
393130009119	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130009120	active site
393130009121	motif I; other site
393130009122	motif II; other site
393130009123	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130009124	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130009125	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130009126	putative active site [active]
393130009127	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
393130009128	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130009129	active site
393130009130	phosphorylation site [posttranslational modification]
393130009131	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
393130009132	active site
393130009133	P-loop; other site
393130009134	phosphorylation site [posttranslational modification]
393130009135	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
393130009136	alpha-mannosidase; Provisional; Region: PRK09819
393130009137	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
393130009138	active site
393130009139	metal binding site [ion binding]; metal-binding site
393130009140	catalytic site [active]
393130009141	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
393130009142	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
393130009143	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
393130009144	active site
393130009145	homodimer interface [polypeptide binding]; other site
393130009146	catalytic site [active]
393130009147	glycerate kinase; Region: TIGR00045
393130009148	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130009149	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130009150	DNA binding site [nucleotide binding]
393130009151	domain linker motif; other site
393130009152	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
393130009153	putative dimerization interface [polypeptide binding]; other site
393130009154	putative ligand binding site [chemical binding]; other site
393130009155	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
393130009156	Domain of unknown function DUF21; Region: DUF21; pfam01595
393130009157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
393130009158	Transporter associated domain; Region: CorC_HlyC; pfam03471
393130009159	NAD-dependent deacetylase; Provisional; Region: PRK00481
393130009160	SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411
393130009161	NAD+ binding site [chemical binding]; other site
393130009162	substrate binding site [chemical binding]; other site
393130009163	putative Zn binding site [ion binding]; other site
393130009164	Pathogenicity locus; Region: Cdd1; pfam11731
393130009165	drug efflux system protein MdtG; Provisional; Region: PRK09874
393130009166	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009167	putative substrate translocation pore; other site
393130009168	Src Homology 3 domain superfamily; Region: SH3; cl17036
393130009169	Variant SH3 domain; Region: SH3_2; pfam07653
393130009170	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
393130009171	active site
393130009172	intersubunit interactions; other site
393130009173	catalytic residue [active]
393130009174	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
393130009175	Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027
393130009176	ligand binding site [chemical binding]; other site
393130009177	flexible hinge region; other site
393130009178	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
393130009179	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130009180	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130009181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130009182	Walker A/P-loop; other site
393130009183	ATP binding site [chemical binding]; other site
393130009184	Q-loop/lid; other site
393130009185	ABC transporter signature motif; other site
393130009186	Walker B; other site
393130009187	D-loop; other site
393130009188	H-loop/switch region; other site
393130009189	TfoX C-terminal domain; Region: TfoX_C; pfam04994
393130009190	seryl-tRNA synthetase; Provisional; Region: PRK05431
393130009191	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
393130009192	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
393130009193	dimer interface [polypeptide binding]; other site
393130009194	active site
393130009195	motif 1; other site
393130009196	motif 2; other site
393130009197	motif 3; other site
393130009198	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
393130009199	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
393130009200	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
393130009201	Glutamine amidotransferase class-I; Region: GATase; pfam00117
393130009202	glutamine binding [chemical binding]; other site
393130009203	catalytic triad [active]
393130009204	aminodeoxychorismate synthase; Provisional; Region: PRK07508
393130009205	chorismate binding enzyme; Region: Chorismate_bind; cl10555
393130009206	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
393130009207	substrate-cofactor binding pocket; other site
393130009208	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
393130009209	pyridoxal 5'-phosphate binding site [chemical binding]; other site
393130009210	catalytic residue [active]
393130009211	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130009212	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130009213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130009214	Walker A/P-loop; other site
393130009215	ATP binding site [chemical binding]; other site
393130009216	Q-loop/lid; other site
393130009217	ABC transporter signature motif; other site
393130009218	Walker B; other site
393130009219	D-loop; other site
393130009220	H-loop/switch region; other site
393130009221	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
393130009222	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
393130009223	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
393130009224	Walker A/P-loop; other site
393130009225	ATP binding site [chemical binding]; other site
393130009226	Q-loop/lid; other site
393130009227	ABC transporter signature motif; other site
393130009228	Walker B; other site
393130009229	D-loop; other site
393130009230	H-loop/switch region; other site
393130009231	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
393130009232	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
393130009233	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
393130009234	Predicted acyl esterases [General function prediction only]; Region: COG2936
393130009235	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
393130009236	DNA topoisomerase III; Provisional; Region: PRK07726
393130009237	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
393130009238	active site
393130009239	putative interdomain interaction site [polypeptide binding]; other site
393130009240	putative metal-binding site [ion binding]; other site
393130009241	putative nucleotide binding site [chemical binding]; other site
393130009242	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
393130009243	domain I; other site
393130009244	DNA binding groove [nucleotide binding]
393130009245	phosphate binding site [ion binding]; other site
393130009246	domain II; other site
393130009247	domain III; other site
393130009248	nucleotide binding site [chemical binding]; other site
393130009249	catalytic site [active]
393130009250	domain IV; other site
393130009251	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
393130009252	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
393130009253	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
393130009254	ATP binding site [chemical binding]; other site
393130009255	putative Mg++ binding site [ion binding]; other site
393130009256	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
393130009257	nucleotide binding region [chemical binding]; other site
393130009258	ATP-binding site [chemical binding]; other site
393130009259	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
393130009260	HRDC domain; Region: HRDC; pfam00570
393130009261	IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516
393130009262	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
393130009263	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
393130009264	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
393130009265	active site
393130009266	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
393130009267	putative ADP-ribose binding site [chemical binding]; other site
393130009268	putative active site [active]
393130009269	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
393130009270	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130009271	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130009272	ABC transporter; Region: ABC_tran_2; pfam12848
393130009273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
393130009274	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
393130009275	beta-galactosidase; Region: BGL; TIGR03356
393130009276	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130009277	active site
393130009278	P-loop; other site
393130009279	phosphorylation site [posttranslational modification]
393130009280	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
393130009281	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130009282	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130009283	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130009284	nucleotide binding site [chemical binding]; other site
393130009285	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130009286	methionine cluster; other site
393130009287	active site
393130009288	phosphorylation site [posttranslational modification]
393130009289	metal binding site [ion binding]; metal-binding site
393130009290	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130009291	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130009292	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130009293	putative active site [active]
393130009294	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
393130009295	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
393130009296	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
393130009297	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
393130009298	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
393130009299	Walker A/P-loop; other site
393130009300	ATP binding site [chemical binding]; other site
393130009301	Q-loop/lid; other site
393130009302	ABC transporter signature motif; other site
393130009303	Walker B; other site
393130009304	D-loop; other site
393130009305	H-loop/switch region; other site
393130009306	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
393130009307	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
393130009308	ATP-grasp domain; Region: ATP-grasp_4; cl17255
393130009309	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
393130009310	beta-galactosidase; Region: BGL; TIGR03356
393130009311	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393130009312	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130009313	active site turn [active]
393130009314	phosphorylation site [posttranslational modification]
393130009315	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130009316	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
393130009317	HPr interaction site; other site
393130009318	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130009319	active site
393130009320	phosphorylation site [posttranslational modification]
393130009321	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393130009322	CAT RNA binding domain; Region: CAT_RBD; smart01061
393130009323	PRD domain; Region: PRD; pfam00874
393130009324	PRD domain; Region: PRD; pfam00874
393130009325	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
393130009326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009327	putative substrate translocation pore; other site
393130009328	GTP-binding protein YchF; Reviewed; Region: PRK09601
393130009329	YchF GTPase; Region: YchF; cd01900
393130009330	G1 box; other site
393130009331	GTP/Mg2+ binding site [chemical binding]; other site
393130009332	Switch I region; other site
393130009333	G2 box; other site
393130009334	Switch II region; other site
393130009335	G3 box; other site
393130009336	G4 box; other site
393130009337	G5 box; other site
393130009338	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
393130009339	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
393130009340	methionine cluster; other site
393130009341	active site
393130009342	phosphorylation site [posttranslational modification]
393130009343	metal binding site [ion binding]; metal-binding site
393130009344	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
393130009345	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
393130009346	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
393130009347	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
393130009348	active site
393130009349	P-loop; other site
393130009350	phosphorylation site [posttranslational modification]
393130009351	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
393130009352	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
393130009353	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
393130009354	HTH domain; Region: HTH_11; pfam08279
393130009355	Mga helix-turn-helix domain; Region: Mga; pfam05043
393130009356	PRD domain; Region: PRD; pfam00874
393130009357	PRD domain; Region: PRD; pfam00874
393130009358	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
393130009359	active site
393130009360	P-loop; other site
393130009361	phosphorylation site [posttranslational modification]
393130009362	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130009363	active site
393130009364	phosphorylation site [posttranslational modification]
393130009365	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
393130009366	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
393130009367	tetramer interface [polypeptide binding]; other site
393130009368	heme binding pocket [chemical binding]; other site
393130009369	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
393130009370	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
393130009371	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
393130009372	active site turn [active]
393130009373	phosphorylation site [posttranslational modification]
393130009374	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
393130009375	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
393130009376	HPr interaction site; other site
393130009377	glycerol kinase (GK) interaction site [polypeptide binding]; other site
393130009378	active site
393130009379	phosphorylation site [posttranslational modification]
393130009380	transcriptional antiterminator BglG; Provisional; Region: PRK09772
393130009381	CAT RNA binding domain; Region: CAT_RBD; pfam03123
393130009382	PRD domain; Region: PRD; pfam00874
393130009383	PRD domain; Region: PRD; pfam00874
393130009384	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
393130009385	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
393130009386	ParB-like nuclease domain; Region: ParB; smart00470
393130009387	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
393130009388	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
393130009389	P-loop; other site
393130009390	Magnesium ion binding site [ion binding]; other site
393130009391	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
393130009392	Magnesium ion binding site [ion binding]; other site
393130009393	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
393130009394	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
393130009395	non-specific DNA binding site [nucleotide binding]; other site
393130009396	salt bridge; other site
393130009397	sequence-specific DNA binding site [nucleotide binding]; other site
393130009398	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
393130009399	ParB-like nuclease domain; Region: ParBc; pfam02195
393130009400	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
393130009401	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
393130009402	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
393130009403	putative active site [active]
393130009404	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
393130009405	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
393130009406	nucleotide binding site [chemical binding]; other site
393130009407	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
393130009408	active site
393130009409	phosphorylation site [posttranslational modification]
393130009410	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
393130009411	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130009412	motif II; other site
393130009413	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
393130009414	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
393130009415	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
393130009416	active site
393130009417	P-loop; other site
393130009418	phosphorylation site [posttranslational modification]
393130009419	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130009420	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130009421	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393130009422	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
393130009423	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
393130009424	putative active site cavity [active]
393130009425	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
393130009426	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
393130009427	S-adenosylmethionine binding site [chemical binding]; other site
393130009428	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
393130009429	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393130009430	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393130009431	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393130009432	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
393130009433	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
393130009434	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
393130009435	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
393130009436	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
393130009437	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
393130009438	trmE is a tRNA modification GTPase; Region: trmE; cd04164
393130009439	G1 box; other site
393130009440	GTP/Mg2+ binding site [chemical binding]; other site
393130009441	Switch I region; other site
393130009442	G2 box; other site
393130009443	Switch II region; other site
393130009444	G3 box; other site
393130009445	G4 box; other site
393130009446	G5 box; other site
393130009447	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
393130009448	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
393130009449	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
393130009450	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
393130009451	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
393130009452	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
393130009453	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
393130009454	NADP binding site [chemical binding]; other site
393130009455	homodimer interface [polypeptide binding]; other site
393130009456	active site
393130009457	substrate binding site [chemical binding]; other site
393130009458	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009459	D-galactonate transporter; Region: 2A0114; TIGR00893
393130009460	putative substrate translocation pore; other site
393130009461	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393130009462	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
393130009463	metal binding site [ion binding]; metal-binding site
393130009464	dimer interface [polypeptide binding]; other site
393130009465	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
393130009466	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
393130009467	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
393130009468	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
393130009469	metal binding site [ion binding]; metal-binding site
393130009470	dimer interface [polypeptide binding]; other site
393130009471	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
393130009472	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
393130009473	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664
393130009474	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
393130009475	Leucine-rich repeats; other site
393130009476	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130009477	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
393130009478	Substrate binding site [chemical binding]; other site
393130009479	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130009480	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130009481	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130009482	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
393130009483	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
393130009484	Uncharacterized conserved protein [Function unknown]; Region: COG4198
393130009485	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
393130009486	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
393130009487	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
393130009488	putative ligand binding site [chemical binding]; other site
393130009489	putative NAD binding site [chemical binding]; other site
393130009490	putative catalytic site [active]
393130009491	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
393130009492	L-serine binding site [chemical binding]; other site
393130009493	ACT domain interface; other site
393130009494	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
393130009495	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
393130009496	catalytic residue [active]
393130009497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009498	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130009499	putative substrate translocation pore; other site
393130009500	Transcriptional regulators [Transcription]; Region: MarR; COG1846
393130009501	MarR family; Region: MarR_2; pfam12802
393130009502	YolD-like protein; Region: YolD; pfam08863
393130009503	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
393130009504	dimer interface [polypeptide binding]; other site
393130009505	FMN binding site [chemical binding]; other site
393130009506	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
393130009507	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
393130009508	catalytic residues [active]
393130009509	beta-phosphoglucomutase; Region: bPGM; TIGR01990
393130009510	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
393130009511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
393130009512	motif II; other site
393130009513	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
393130009514	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
393130009515	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
393130009516	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
393130009517	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
393130009518	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
393130009519	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
393130009520	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
393130009521	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
393130009522	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
393130009523	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
393130009524	putative NAD(P) binding site [chemical binding]; other site
393130009525	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
393130009526	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130009527	dimer interface [polypeptide binding]; other site
393130009528	conserved gate region; other site
393130009529	putative PBP binding loops; other site
393130009530	ABC-ATPase subunit interface; other site
393130009531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
393130009532	dimer interface [polypeptide binding]; other site
393130009533	conserved gate region; other site
393130009534	putative PBP binding loops; other site
393130009535	ABC-ATPase subunit interface; other site
393130009536	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
393130009537	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
393130009538	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
393130009539	sucrose phosphorylase; Provisional; Region: PRK13840
393130009540	active site
393130009541	homodimer interface [polypeptide binding]; other site
393130009542	catalytic site [active]
393130009543	Transcriptional regulators [Transcription]; Region: PurR; COG1609
393130009544	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
393130009545	DNA binding site [nucleotide binding]
393130009546	domain linker motif; other site
393130009547	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
393130009548	putative dimerization interface [polypeptide binding]; other site
393130009549	putative ligand binding site [chemical binding]; other site
393130009550	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
393130009551	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
393130009552	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
393130009553	Coenzyme A binding pocket [chemical binding]; other site
393130009554	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009555	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130009556	putative substrate translocation pore; other site
393130009557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009558	Domain of unknown function (DUF718); Region: DUF718; cl01281
393130009559	rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624
393130009560	intersubunit interface [polypeptide binding]; other site
393130009561	active site
393130009562	Zn2+ binding site [ion binding]; other site
393130009563	L-rhamnose isomerase; Provisional; Region: PRK01076
393130009564	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
393130009565	N- and C-terminal domain interface [polypeptide binding]; other site
393130009566	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
393130009567	active site
393130009568	putative catalytic site [active]
393130009569	metal binding site [ion binding]; metal-binding site
393130009570	ATP binding site [chemical binding]; other site
393130009571	carbohydrate binding site [chemical binding]; other site
393130009572	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
393130009573	putative substrate translocation pore; other site
393130009574	Major Facilitator Superfamily; Region: MFS_1; pfam07690
393130009575	Cupin domain; Region: Cupin_2; pfam07883
393130009576	Helix-turn-helix domain; Region: HTH_18; pfam12833
393130009577	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
393130009578	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
393130009579	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
393130009580	G-X-X-G motif; other site
393130009581	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
393130009582	RxxxH motif; other site
393130009583	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
393130009584	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
393130009585	ribonuclease P; Reviewed; Region: rnpA; PRK00499
393130009586	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399