-- dump date 20140619_132743 -- class Genbank::misc_feature -- table misc_feature_note -- id note 930781000001 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930781000002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781000003 Walker A/P-loop; other site 930781000004 ATP binding site [chemical binding]; other site 930781000005 Q-loop/lid; other site 930781000006 ABC transporter signature motif; other site 930781000007 Walker B; other site 930781000008 D-loop; other site 930781000009 H-loop/switch region; other site 930781000010 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930781000011 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781000012 active site 930781000013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781000014 non-specific DNA binding site [nucleotide binding]; other site 930781000015 salt bridge; other site 930781000016 sequence-specific DNA binding site [nucleotide binding]; other site 930781000017 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 930781000018 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 930781000019 active site 930781000020 catalytic triad [active] 930781000021 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930781000022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781000023 Walker A motif; other site 930781000024 ATP binding site [chemical binding]; other site 930781000025 Walker B motif; other site 930781000026 arginine finger; other site 930781000027 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 930781000028 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 930781000029 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 930781000030 integrase; Provisional; Region: int; PHA02601 930781000031 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930781000032 Int/Topo IB signature motif; other site 930781000033 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930781000034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781000035 non-specific DNA binding site [nucleotide binding]; other site 930781000036 salt bridge; other site 930781000037 sequence-specific DNA binding site [nucleotide binding]; other site 930781000038 GMP synthase; Reviewed; Region: guaA; PRK00074 930781000039 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 930781000040 AMP/PPi binding site [chemical binding]; other site 930781000041 candidate oxyanion hole; other site 930781000042 catalytic triad [active] 930781000043 potential glutamine specificity residues [chemical binding]; other site 930781000044 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 930781000045 ATP Binding subdomain [chemical binding]; other site 930781000046 Dimerization subdomain; other site 930781000047 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 930781000048 active site 930781000049 P-loop; other site 930781000050 phosphorylation site [posttranslational modification] 930781000051 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930781000052 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 930781000053 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 930781000054 homodimer interface [polypeptide binding]; other site 930781000055 NAD binding pocket [chemical binding]; other site 930781000056 ATP binding pocket [chemical binding]; other site 930781000057 Mg binding site [ion binding]; other site 930781000058 active-site loop [active] 930781000059 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 930781000060 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 930781000061 active site 930781000062 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 930781000063 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 930781000064 active site 930781000065 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930781000066 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930781000067 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 930781000068 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930781000069 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930781000070 active site 930781000071 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 930781000072 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930781000073 putative NAD(P) binding site [chemical binding]; other site 930781000074 putative catalytic Zn binding site [ion binding]; other site 930781000075 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930781000076 substrate binding site; other site 930781000077 dimer interface; other site 930781000078 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930781000079 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930781000080 active site 930781000081 tetramer interface; other site 930781000082 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 930781000083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930781000084 active site 930781000085 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930781000086 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 930781000087 conserved hypothetical integral membrane protein; Region: TIGR03766 930781000088 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 930781000089 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 930781000090 Ligand binding site; other site 930781000091 Putative Catalytic site; other site 930781000092 DXD motif; other site 930781000093 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781000094 SH3-like domain; Region: SH3_8; pfam13457 930781000095 SH3-like domain; Region: SH3_8; pfam13457 930781000096 SH3-like domain; Region: SH3_8; pfam13457 930781000097 SH3-like domain; Region: SH3_8; pfam13457 930781000098 SH3-like domain; Region: SH3_8; pfam13457 930781000099 SH3-like domain; Region: SH3_8; pfam13457 930781000100 SH3-like domain; Region: SH3_8; pfam13457 930781000101 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 930781000102 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930781000103 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 930781000104 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930781000105 putative binding site residues; other site 930781000106 pyruvate carboxylase; Reviewed; Region: PRK12999 930781000107 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930781000108 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930781000109 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930781000110 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 930781000111 active site 930781000112 catalytic residues [active] 930781000113 metal binding site [ion binding]; metal-binding site 930781000114 homodimer binding site [polypeptide binding]; other site 930781000115 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930781000116 carboxyltransferase (CT) interaction site; other site 930781000117 biotinylation site [posttranslational modification]; other site 930781000118 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930781000119 hypothetical protein; Provisional; Region: PRK13666 930781000120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 930781000121 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 930781000122 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 930781000123 G1 box; other site 930781000124 putative GEF interaction site [polypeptide binding]; other site 930781000125 GTP/Mg2+ binding site [chemical binding]; other site 930781000126 Switch I region; other site 930781000127 G2 box; other site 930781000128 G3 box; other site 930781000129 Switch II region; other site 930781000130 G4 box; other site 930781000131 G5 box; other site 930781000132 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 930781000133 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 930781000134 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 930781000135 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930781000136 active site 930781000137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 930781000138 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 930781000139 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930781000140 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930781000141 Cl binding site [ion binding]; other site 930781000142 oligomer interface [polypeptide binding]; other site 930781000143 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 930781000144 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 930781000145 catalytic residues [active] 930781000146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 930781000147 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 930781000148 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 930781000149 NAD(P) binding site [chemical binding]; other site 930781000150 LDH/MDH dimer interface [polypeptide binding]; other site 930781000151 substrate binding site [chemical binding]; other site 930781000152 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 930781000153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930781000154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781000155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930781000156 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 930781000157 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930781000158 E3 interaction surface; other site 930781000159 lipoyl attachment site [posttranslational modification]; other site 930781000160 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930781000161 E3 interaction surface; other site 930781000162 lipoyl attachment site [posttranslational modification]; other site 930781000163 e3 binding domain; Region: E3_binding; pfam02817 930781000164 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930781000165 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930781000166 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930781000167 alpha subunit interface [polypeptide binding]; other site 930781000168 TPP binding site [chemical binding]; other site 930781000169 heterodimer interface [polypeptide binding]; other site 930781000170 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781000171 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930781000172 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930781000173 TPP-binding site [chemical binding]; other site 930781000174 tetramer interface [polypeptide binding]; other site 930781000175 heterodimer interface [polypeptide binding]; other site 930781000176 phosphorylation loop region [posttranslational modification] 930781000177 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930781000178 active site 930781000179 catalytic residues [active] 930781000180 metal binding site [ion binding]; metal-binding site 930781000181 Flavin Reductases; Region: FlaRed; cl00801 930781000182 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 930781000183 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930781000184 ATP binding site [chemical binding]; other site 930781000185 substrate interface [chemical binding]; other site 930781000186 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 930781000187 MPT binding site; other site 930781000188 trimer interface [polypeptide binding]; other site 930781000189 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 930781000190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930781000191 FeS/SAM binding site; other site 930781000192 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930781000193 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 930781000194 trimer interface [polypeptide binding]; other site 930781000195 dimer interface [polypeptide binding]; other site 930781000196 putative active site [active] 930781000197 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 930781000198 MoaE interaction surface [polypeptide binding]; other site 930781000199 MoeB interaction surface [polypeptide binding]; other site 930781000200 thiocarboxylated glycine; other site 930781000201 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930781000202 MoaE homodimer interface [polypeptide binding]; other site 930781000203 MoaD interaction [polypeptide binding]; other site 930781000204 active site residues [active] 930781000205 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 930781000206 Walker A motif; other site 930781000207 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930781000208 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930781000209 dimer interface [polypeptide binding]; other site 930781000210 putative functional site; other site 930781000211 putative MPT binding site; other site 930781000212 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 930781000213 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930781000214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000215 dimer interface [polypeptide binding]; other site 930781000216 conserved gate region; other site 930781000217 putative PBP binding loops; other site 930781000218 ABC-ATPase subunit interface; other site 930781000219 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 930781000220 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930781000221 Walker A/P-loop; other site 930781000222 ATP binding site [chemical binding]; other site 930781000223 Q-loop/lid; other site 930781000224 ABC transporter signature motif; other site 930781000225 Walker B; other site 930781000226 D-loop; other site 930781000227 H-loop/switch region; other site 930781000228 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 930781000229 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 930781000230 GTP binding site; other site 930781000231 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 930781000232 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 930781000233 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 930781000234 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930781000235 PYR/PP interface [polypeptide binding]; other site 930781000236 dimer interface [polypeptide binding]; other site 930781000237 TPP binding site [chemical binding]; other site 930781000238 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781000239 transketolase; Reviewed; Region: PRK05899 930781000240 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930781000241 TPP-binding site [chemical binding]; other site 930781000242 dimer interface [polypeptide binding]; other site 930781000243 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 930781000244 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930781000245 trimer interface [polypeptide binding]; other site 930781000246 substrate binding site [chemical binding]; other site 930781000247 Mn binding site [ion binding]; other site 930781000248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781000249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781000250 DNA binding site [nucleotide binding] 930781000251 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930781000252 ligand binding site [chemical binding]; other site 930781000253 dimerization interface [polypeptide binding]; other site 930781000254 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781000255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781000256 active site 930781000257 motif I; other site 930781000258 motif II; other site 930781000259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781000260 hypothetical protein; Provisional; Region: PRK13667 930781000261 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930781000262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930781000263 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930781000264 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 930781000265 Predicted membrane protein [Function unknown]; Region: COG1289 930781000266 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 930781000267 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930781000268 TrkA-N domain; Region: TrkA_N; pfam02254 930781000269 TrkA-C domain; Region: TrkA_C; pfam02080 930781000270 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930781000271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781000272 active site 930781000273 phosphorylation site [posttranslational modification] 930781000274 intermolecular recognition site; other site 930781000275 dimerization interface [polypeptide binding]; other site 930781000276 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930781000277 DNA binding residues [nucleotide binding] 930781000278 dimerization interface [polypeptide binding]; other site 930781000279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930781000280 Histidine kinase; Region: HisKA_3; pfam07730 930781000281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781000282 ATP binding site [chemical binding]; other site 930781000283 Mg2+ binding site [ion binding]; other site 930781000284 G-X-G motif; other site 930781000285 Predicted membrane protein [Function unknown]; Region: COG4758 930781000286 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 930781000287 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 930781000288 S1 domain; Region: S1_2; pfam13509 930781000289 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 930781000290 RNA binding site [nucleotide binding]; other site 930781000291 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 930781000292 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 930781000293 HPr interaction site; other site 930781000294 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930781000295 active site 930781000296 phosphorylation site [posttranslational modification] 930781000297 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 930781000298 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930781000299 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930781000300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000301 dimer interface [polypeptide binding]; other site 930781000302 conserved gate region; other site 930781000303 putative PBP binding loops; other site 930781000304 ABC-ATPase subunit interface; other site 930781000305 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 930781000306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781000307 Walker A/P-loop; other site 930781000308 ATP binding site [chemical binding]; other site 930781000309 Q-loop/lid; other site 930781000310 ABC transporter signature motif; other site 930781000311 Walker B; other site 930781000312 D-loop; other site 930781000313 H-loop/switch region; other site 930781000314 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 930781000315 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930781000316 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 930781000317 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930781000318 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930781000319 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 930781000320 metal binding site [ion binding]; metal-binding site 930781000321 putative dimer interface [polypeptide binding]; other site 930781000322 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 930781000323 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 930781000324 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930781000325 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930781000326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781000327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781000328 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930781000329 dimerization interface [polypeptide binding]; other site 930781000330 FOG: CBS domain [General function prediction only]; Region: COG0517 930781000331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 930781000332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 930781000333 aminotransferase A; Validated; Region: PRK07683 930781000334 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781000335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781000336 homodimer interface [polypeptide binding]; other site 930781000337 catalytic residue [active] 930781000338 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930781000339 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930781000340 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930781000341 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930781000342 putative active site [active] 930781000343 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 930781000344 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 930781000345 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930781000346 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930781000347 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930781000348 dimerization domain swap beta strand [polypeptide binding]; other site 930781000349 regulatory protein interface [polypeptide binding]; other site 930781000350 active site 930781000351 regulatory phosphorylation site [posttranslational modification]; other site 930781000352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 930781000353 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 930781000354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930781000355 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 930781000356 nucleotide binding site [chemical binding]; other site 930781000357 CAAX protease self-immunity; Region: Abi; pfam02517 930781000358 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 930781000359 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781000360 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930781000361 Walker A motif; other site 930781000362 ATP binding site [chemical binding]; other site 930781000363 Walker B motif; other site 930781000364 arginine finger; other site 930781000365 UvrB/uvrC motif; Region: UVR; pfam02151 930781000366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781000367 Walker A motif; other site 930781000368 ATP binding site [chemical binding]; other site 930781000369 Walker B motif; other site 930781000370 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930781000371 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 930781000372 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930781000373 DNA binding site [nucleotide binding] 930781000374 active site 930781000375 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 930781000376 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930781000377 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930781000378 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930781000379 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781000380 MarR family; Region: MarR_2; cl17246 930781000381 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 930781000382 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 930781000383 G1 box; other site 930781000384 putative GEF interaction site [polypeptide binding]; other site 930781000385 GTP/Mg2+ binding site [chemical binding]; other site 930781000386 Switch I region; other site 930781000387 G2 box; other site 930781000388 G3 box; other site 930781000389 Switch II region; other site 930781000390 G4 box; other site 930781000391 G5 box; other site 930781000392 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 930781000393 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930781000394 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930781000395 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781000396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781000397 Walker A/P-loop; other site 930781000398 ATP binding site [chemical binding]; other site 930781000399 Q-loop/lid; other site 930781000400 ABC transporter signature motif; other site 930781000401 Walker B; other site 930781000402 D-loop; other site 930781000403 H-loop/switch region; other site 930781000404 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 930781000405 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930781000406 LytTr DNA-binding domain; Region: LytTR; pfam04397 930781000407 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 930781000408 catalytic residues [active] 930781000409 dimer interface [polypeptide binding]; other site 930781000410 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930781000411 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 930781000412 putative oligomer interface [polypeptide binding]; other site 930781000413 putative active site [active] 930781000414 metal binding site [ion binding]; metal-binding site 930781000415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781000416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781000417 putative substrate translocation pore; other site 930781000418 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930781000419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930781000420 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930781000421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781000422 Walker A/P-loop; other site 930781000423 ATP binding site [chemical binding]; other site 930781000424 Q-loop/lid; other site 930781000425 ABC transporter signature motif; other site 930781000426 Walker B; other site 930781000427 D-loop; other site 930781000428 H-loop/switch region; other site 930781000429 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 930781000430 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 930781000431 homodimer interface [polypeptide binding]; other site 930781000432 substrate-cofactor binding pocket; other site 930781000433 catalytic residue [active] 930781000434 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930781000435 Putative esterase; Region: Esterase; pfam00756 930781000436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781000437 Coenzyme A binding pocket [chemical binding]; other site 930781000438 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 930781000439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781000440 active site 930781000441 dimer interface [polypeptide binding]; other site 930781000442 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 930781000443 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 930781000444 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 930781000445 acyl-activating enzyme (AAE) consensus motif; other site 930781000446 AMP binding site [chemical binding]; other site 930781000447 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 930781000448 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930781000449 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 930781000450 DltD N-terminal region; Region: DltD_N; pfam04915 930781000451 DltD central region; Region: DltD_M; pfam04918 930781000452 DltD C-terminal region; Region: DltD_C; pfam04914 930781000453 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 930781000454 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 930781000455 NAD binding site [chemical binding]; other site 930781000456 homotetramer interface [polypeptide binding]; other site 930781000457 homodimer interface [polypeptide binding]; other site 930781000458 substrate binding site [chemical binding]; other site 930781000459 active site 930781000460 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930781000461 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930781000462 active site 930781000463 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 930781000464 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930781000465 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930781000466 synthetase active site [active] 930781000467 NTP binding site [chemical binding]; other site 930781000468 metal binding site [ion binding]; metal-binding site 930781000469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781000470 TPR motif; other site 930781000471 binding surface 930781000472 Tetratrico peptide repeat; Region: TPR_5; pfam12688 930781000473 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 930781000474 putative active site [active] 930781000475 putative metal binding residues [ion binding]; other site 930781000476 signature motif; other site 930781000477 putative triphosphate binding site [ion binding]; other site 930781000478 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930781000479 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 930781000480 catalytic residues [active] 930781000481 heat shock protein HtpX; Provisional; Region: PRK04897 930781000482 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930781000483 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930781000484 Peptidase family U32; Region: Peptidase_U32; pfam01136 930781000485 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930781000486 Peptidase family U32; Region: Peptidase_U32; pfam01136 930781000487 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930781000488 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930781000489 Mg++ binding site [ion binding]; other site 930781000490 putative catalytic motif [active] 930781000491 substrate binding site [chemical binding]; other site 930781000492 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781000493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781000494 DNA-binding site [nucleotide binding]; DNA binding site 930781000495 UTRA domain; Region: UTRA; pfam07702 930781000496 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930781000497 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930781000498 active site 930781000499 dimer interface [polypeptide binding]; other site 930781000500 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 930781000501 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 930781000502 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 930781000503 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 930781000504 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 930781000505 PGAP1-like protein; Region: PGAP1; pfam07819 930781000506 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930781000507 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930781000508 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930781000509 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781000510 DNA-binding site [nucleotide binding]; DNA binding site 930781000511 FCD domain; Region: FCD; pfam07729 930781000512 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 930781000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781000514 putative substrate translocation pore; other site 930781000515 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 930781000516 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930781000517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781000518 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 930781000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 930781000520 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930781000521 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930781000522 dimerization interface [polypeptide binding]; other site 930781000523 DPS ferroxidase diiron center [ion binding]; other site 930781000524 ion pore; other site 930781000525 HSP90 family protein; Provisional; Region: PRK14083 930781000526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781000527 ATP binding site [chemical binding]; other site 930781000528 Mg2+ binding site [ion binding]; other site 930781000529 G-X-G motif; other site 930781000530 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 930781000531 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930781000532 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930781000533 active site 930781000534 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930781000535 dimer interface [polypeptide binding]; other site 930781000536 FMN binding site [chemical binding]; other site 930781000537 NADPH bind site [chemical binding]; other site 930781000538 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 930781000539 epoxyqueuosine reductase; Region: TIGR00276 930781000540 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 930781000541 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 930781000542 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930781000543 Uncharacterized conserved protein [Function unknown]; Region: COG0398 930781000544 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930781000545 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930781000546 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 930781000547 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 930781000548 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 930781000549 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 930781000550 active site 930781000551 catalytic site [active] 930781000552 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 930781000553 active site 930781000554 DNA binding site [nucleotide binding] 930781000555 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930781000556 Domain of unknown function (DUF373); Region: DUF373; cl12079 930781000557 Sulfatase; Region: Sulfatase; pfam00884 930781000558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781000559 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781000560 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930781000561 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930781000562 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 930781000563 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930781000564 Walker A/P-loop; other site 930781000565 ATP binding site [chemical binding]; other site 930781000566 Q-loop/lid; other site 930781000567 ABC transporter signature motif; other site 930781000568 Walker B; other site 930781000569 D-loop; other site 930781000570 H-loop/switch region; other site 930781000571 pantothenate kinase; Provisional; Region: PRK05439 930781000572 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 930781000573 ATP-binding site [chemical binding]; other site 930781000574 CoA-binding site [chemical binding]; other site 930781000575 Mg2+-binding site [ion binding]; other site 930781000576 Predicted membrane protein [Function unknown]; Region: COG3689 930781000577 Predicted permeases [General function prediction only]; Region: COG0701 930781000578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781000579 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930781000580 ABC transporter; Region: ABC_tran_2; pfam12848 930781000581 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781000582 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 930781000583 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781000584 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781000585 PRD domain; Region: PRD; pfam00874 930781000586 PRD domain; Region: PRD; pfam00874 930781000587 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781000588 active site 930781000589 phosphorylation site [posttranslational modification] 930781000590 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781000591 beta-galactosidase; Region: BGL; TIGR03356 930781000592 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781000593 methionine cluster; other site 930781000594 active site 930781000595 phosphorylation site [posttranslational modification] 930781000596 metal binding site [ion binding]; metal-binding site 930781000597 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781000598 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781000599 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930781000600 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930781000601 tetramerization interface [polypeptide binding]; other site 930781000602 NAD(P) binding site [chemical binding]; other site 930781000603 catalytic residues [active] 930781000604 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 930781000605 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930781000606 Predicted membrane protein [General function prediction only]; Region: COG4194 930781000607 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930781000608 Predicted transcriptional regulators [Transcription]; Region: COG1725 930781000609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781000610 DNA-binding site [nucleotide binding]; DNA binding site 930781000611 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930781000612 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930781000613 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781000614 catalytic core [active] 930781000615 glutathione reductase; Validated; Region: PRK06116 930781000616 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781000617 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781000618 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930781000619 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 930781000620 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930781000621 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 930781000622 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781000623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781000624 DNA-binding site [nucleotide binding]; DNA binding site 930781000625 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930781000626 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781000627 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781000628 Uncharacterized conserved protein [Function unknown]; Region: COG5646 930781000629 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930781000630 hypothetical protein; Provisional; Region: PRK04351 930781000631 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 930781000632 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 930781000633 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 930781000634 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 930781000635 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 930781000636 RNA binding site [nucleotide binding]; other site 930781000637 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 930781000638 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930781000639 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930781000640 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930781000641 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 930781000642 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 930781000643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930781000644 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930781000645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930781000646 DNA binding residues [nucleotide binding] 930781000647 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930781000648 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781000649 ATP binding site [chemical binding]; other site 930781000650 Mg2+ binding site [ion binding]; other site 930781000651 G-X-G motif; other site 930781000652 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 930781000653 anti sigma factor interaction site; other site 930781000654 regulatory phosphorylation site [posttranslational modification]; other site 930781000655 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 930781000656 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 930781000657 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 930781000658 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930781000659 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 930781000660 ATP binding site [chemical binding]; other site 930781000661 Mg2+ binding site [ion binding]; other site 930781000662 G-X-G motif; other site 930781000663 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781000664 Rsbr N terminal; Region: Rsbr_N; pfam08678 930781000665 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781000666 PemK-like protein; Region: PemK; pfam02452 930781000667 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 930781000668 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 930781000669 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 930781000670 active site 930781000671 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930781000672 dimer interface [polypeptide binding]; other site 930781000673 substrate binding site [chemical binding]; other site 930781000674 catalytic residues [active] 930781000675 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 930781000676 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 930781000677 Predicted membrane protein [Function unknown]; Region: COG3428 930781000678 Bacterial PH domain; Region: DUF304; pfam03703 930781000679 Bacterial PH domain; Region: DUF304; pfam03703 930781000680 Bacterial PH domain; Region: DUF304; pfam03703 930781000681 Uncharacterized conserved protein [Function unknown]; Region: COG3402 930781000682 Collagen binding domain; Region: Collagen_bind; pfam05737 930781000683 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781000684 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930781000685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781000686 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781000687 active site 930781000688 catalytic tetrad [active] 930781000689 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930781000690 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930781000691 active site 930781000692 trimer interface [polypeptide binding]; other site 930781000693 allosteric site; other site 930781000694 active site lid [active] 930781000695 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930781000696 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781000697 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781000698 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781000699 active site 930781000700 P-loop; other site 930781000701 phosphorylation site [posttranslational modification] 930781000702 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781000703 methionine cluster; other site 930781000704 active site 930781000705 phosphorylation site [posttranslational modification] 930781000706 metal binding site [ion binding]; metal-binding site 930781000707 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781000708 PRD domain; Region: PRD; pfam00874 930781000709 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781000710 active site 930781000711 P-loop; other site 930781000712 phosphorylation site [posttranslational modification] 930781000713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781000714 active site 930781000715 phosphorylation site [posttranslational modification] 930781000716 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930781000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781000718 putative substrate translocation pore; other site 930781000719 Predicted transcriptional regulators [Transcription]; Region: COG1733 930781000720 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930781000721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 930781000722 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 930781000723 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930781000724 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930781000725 ATP binding site [chemical binding]; other site 930781000726 Mg++ binding site [ion binding]; other site 930781000727 motif III; other site 930781000728 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781000729 nucleotide binding region [chemical binding]; other site 930781000730 ATP-binding site [chemical binding]; other site 930781000731 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930781000732 active site 930781000733 substrate binding site [chemical binding]; other site 930781000734 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 930781000735 metal binding site [ion binding]; metal-binding site 930781000736 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 930781000737 active site 930781000738 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 930781000739 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930781000740 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930781000741 Ca binding site [ion binding]; other site 930781000742 active site 930781000743 catalytic site [active] 930781000744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000746 dimer interface [polypeptide binding]; other site 930781000747 conserved gate region; other site 930781000748 ABC-ATPase subunit interface; other site 930781000749 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930781000750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000751 dimer interface [polypeptide binding]; other site 930781000752 conserved gate region; other site 930781000753 putative PBP binding loops; other site 930781000754 ABC-ATPase subunit interface; other site 930781000755 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930781000756 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781000757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781000758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781000759 DNA binding site [nucleotide binding] 930781000760 domain linker motif; other site 930781000761 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 930781000762 putative dimerization interface [polypeptide binding]; other site 930781000763 putative ligand binding site [chemical binding]; other site 930781000764 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 930781000765 Esterase/lipase [General function prediction only]; Region: COG1647 930781000766 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 930781000767 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930781000768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930781000769 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 930781000770 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 930781000771 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 930781000772 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930781000773 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930781000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781000776 amidase; Provisional; Region: PRK11910 930781000777 amidase; Provisional; Region: PRK06707 930781000778 Amidase; Region: Amidase; cl11426 930781000779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930781000780 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930781000781 Walker A/P-loop; other site 930781000782 ATP binding site [chemical binding]; other site 930781000783 Q-loop/lid; other site 930781000784 ABC transporter signature motif; other site 930781000785 Walker B; other site 930781000786 D-loop; other site 930781000787 H-loop/switch region; other site 930781000788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930781000789 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930781000790 substrate binding pocket [chemical binding]; other site 930781000791 membrane-bound complex binding site; other site 930781000792 hinge residues; other site 930781000793 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930781000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000795 dimer interface [polypeptide binding]; other site 930781000796 conserved gate region; other site 930781000797 putative PBP binding loops; other site 930781000798 ABC-ATPase subunit interface; other site 930781000799 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930781000800 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930781000801 GIY-YIG motif/motif A; other site 930781000802 active site 930781000803 catalytic site [active] 930781000804 putative DNA binding site [nucleotide binding]; other site 930781000805 metal binding site [ion binding]; metal-binding site 930781000806 UvrB/uvrC motif; Region: UVR; pfam02151 930781000807 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930781000808 substrate binding site [chemical binding]; other site 930781000809 zinc-binding site [ion binding]; other site 930781000810 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 930781000811 homotrimer interaction site [polypeptide binding]; other site 930781000812 putative active site [active] 930781000813 Predicted membrane protein [Function unknown]; Region: COG3326 930781000814 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000815 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000816 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000817 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000818 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000819 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000820 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781000821 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781000822 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930781000823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930781000824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781000825 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930781000826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781000827 motif II; other site 930781000828 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930781000829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781000830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781000831 putative DNA binding site [nucleotide binding]; other site 930781000832 putative Zn2+ binding site [ion binding]; other site 930781000833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781000834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781000835 putative substrate translocation pore; other site 930781000836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781000837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781000838 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930781000839 Walker A/P-loop; other site 930781000840 ATP binding site [chemical binding]; other site 930781000841 Q-loop/lid; other site 930781000842 ABC transporter signature motif; other site 930781000843 Walker B; other site 930781000844 D-loop; other site 930781000845 H-loop/switch region; other site 930781000846 Predicted membrane protein [Function unknown]; Region: COG3223 930781000847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781000848 non-specific DNA binding site [nucleotide binding]; other site 930781000849 salt bridge; other site 930781000850 sequence-specific DNA binding site [nucleotide binding]; other site 930781000851 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930781000852 Helix-turn-helix domain; Region: HTH_28; pfam13518 930781000853 Predicted permeases [General function prediction only]; Region: COG0679 930781000854 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 930781000855 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 930781000856 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 930781000857 dimer interface [polypeptide binding]; other site 930781000858 PYR/PP interface [polypeptide binding]; other site 930781000859 TPP binding site [chemical binding]; other site 930781000860 substrate binding site [chemical binding]; other site 930781000861 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 930781000862 Domain of unknown function; Region: EKR; smart00890 930781000863 4Fe-4S binding domain; Region: Fer4_6; pfam12837 930781000864 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 930781000865 TPP-binding site [chemical binding]; other site 930781000866 dimer interface [polypeptide binding]; other site 930781000867 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 930781000868 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930781000869 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930781000870 PhoU domain; Region: PhoU; pfam01895 930781000871 PhoU domain; Region: PhoU; pfam01895 930781000872 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 930781000873 homodimer interface [polypeptide binding]; other site 930781000874 catalytic residues [active] 930781000875 NAD binding site [chemical binding]; other site 930781000876 substrate binding pocket [chemical binding]; other site 930781000877 flexible flap; other site 930781000878 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930781000879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781000880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781000881 active site 930781000882 catalytic tetrad [active] 930781000883 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781000884 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781000885 DNA binding residues [nucleotide binding] 930781000886 putative dimer interface [polypeptide binding]; other site 930781000887 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930781000888 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781000889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781000890 Coenzyme A binding pocket [chemical binding]; other site 930781000891 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930781000892 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930781000893 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781000894 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930781000895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781000896 motif II; other site 930781000897 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930781000898 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930781000899 dimer interface [polypeptide binding]; other site 930781000900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781000901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930781000902 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781000903 Coenzyme A binding pocket [chemical binding]; other site 930781000904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930781000905 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781000906 MarR family; Region: MarR_2; pfam12802 930781000907 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 930781000908 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930781000909 FMN binding site [chemical binding]; other site 930781000910 substrate binding site [chemical binding]; other site 930781000911 putative catalytic residue [active] 930781000912 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781000913 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781000914 nucleotide binding site [chemical binding]; other site 930781000915 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930781000916 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781000917 Zn2+ binding site [ion binding]; other site 930781000918 Mg2+ binding site [ion binding]; other site 930781000919 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 930781000920 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 930781000921 active site 930781000922 zinc binding site [ion binding]; other site 930781000923 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 930781000924 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 930781000925 putative active site [active] 930781000926 putative NTP binding site [chemical binding]; other site 930781000927 putative nucleic acid binding site [nucleotide binding]; other site 930781000928 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781000929 non-specific DNA binding site [nucleotide binding]; other site 930781000930 salt bridge; other site 930781000931 sequence-specific DNA binding site [nucleotide binding]; other site 930781000932 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 930781000933 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781000934 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781000935 DNA binding residues [nucleotide binding] 930781000936 putative dimer interface [polypeptide binding]; other site 930781000937 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 930781000938 classical (c) SDRs; Region: SDR_c; cd05233 930781000939 NAD(P) binding site [chemical binding]; other site 930781000940 active site 930781000941 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 930781000942 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 930781000943 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930781000944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000945 dimer interface [polypeptide binding]; other site 930781000946 conserved gate region; other site 930781000947 putative PBP binding loops; other site 930781000948 ABC-ATPase subunit interface; other site 930781000949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930781000950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781000951 putative PBP binding loops; other site 930781000952 ABC-ATPase subunit interface; other site 930781000953 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930781000954 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 930781000955 Walker A/P-loop; other site 930781000956 ATP binding site [chemical binding]; other site 930781000957 Q-loop/lid; other site 930781000958 ABC transporter signature motif; other site 930781000959 Walker B; other site 930781000960 D-loop; other site 930781000961 H-loop/switch region; other site 930781000962 TOBE domain; Region: TOBE_2; pfam08402 930781000963 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781000964 non-specific DNA binding site [nucleotide binding]; other site 930781000965 salt bridge; other site 930781000966 sequence-specific DNA binding site [nucleotide binding]; other site 930781000967 Cupin domain; Region: Cupin_2; pfam07883 930781000968 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930781000969 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 930781000970 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930781000971 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930781000972 synthetase active site [active] 930781000973 NTP binding site [chemical binding]; other site 930781000974 metal binding site [ion binding]; metal-binding site 930781000975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 930781000976 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930781000977 PAS domain; Region: PAS_9; pfam13426 930781000978 putative active site [active] 930781000979 heme pocket [chemical binding]; other site 930781000980 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781000981 lysine transporter; Provisional; Region: PRK10836 930781000982 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930781000983 MarR family; Region: MarR_2; pfam12802 930781000984 Uncharacterized conserved protein [Function unknown]; Region: COG2353 930781000985 Predicted permeases [General function prediction only]; Region: RarD; COG2962 930781000986 EamA-like transporter family; Region: EamA; pfam00892 930781000987 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930781000988 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930781000989 NAD binding site [chemical binding]; other site 930781000990 substrate binding site [chemical binding]; other site 930781000991 putative active site [active] 930781000992 Protein of unknown function (DUF554); Region: DUF554; pfam04474 930781000993 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930781000994 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 930781000995 active site 930781000996 catalytic triad [active] 930781000997 dimer interface [polypeptide binding]; other site 930781000998 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 930781000999 putative deacylase active site [active] 930781001000 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 930781001001 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930781001002 Leucine rich repeat; Region: LRR_8; pfam13855 930781001003 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001004 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001005 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001006 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001007 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001008 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781001009 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 930781001010 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 930781001011 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 930781001012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 930781001013 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 930781001014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 930781001015 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 930781001016 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 930781001017 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930781001018 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 930781001019 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781001020 Walker A motif; other site 930781001021 ATP binding site [chemical binding]; other site 930781001022 Walker B motif; other site 930781001023 arginine finger; other site 930781001024 Transcriptional antiterminator [Transcription]; Region: COG3933 930781001025 PRD domain; Region: PRD; pfam00874 930781001026 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781001027 active pocket/dimerization site; other site 930781001028 active site 930781001029 phosphorylation site [posttranslational modification] 930781001030 PRD domain; Region: PRD; pfam00874 930781001031 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781001032 active pocket/dimerization site; other site 930781001033 active site 930781001034 phosphorylation site [posttranslational modification] 930781001035 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930781001036 active site 930781001037 phosphorylation site [posttranslational modification] 930781001038 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 930781001039 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 930781001040 Predicted membrane protein [Function unknown]; Region: COG4811 930781001041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781001042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781001043 nucleotide binding site [chemical binding]; other site 930781001044 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 930781001045 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930781001046 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 930781001047 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 930781001048 putative NADP binding site [chemical binding]; other site 930781001049 putative dimer interface [polypeptide binding]; other site 930781001050 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930781001051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001052 DNA-binding site [nucleotide binding]; DNA binding site 930781001053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001054 DNA-binding site [nucleotide binding]; DNA binding site 930781001055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781001056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930781001057 ligand binding site [chemical binding]; other site 930781001058 dimerization interface [polypeptide binding]; other site 930781001059 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 930781001060 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930781001061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930781001062 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781001064 dimer interface [polypeptide binding]; other site 930781001065 conserved gate region; other site 930781001066 putative PBP binding loops; other site 930781001067 ABC-ATPase subunit interface; other site 930781001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930781001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781001070 putative PBP binding loops; other site 930781001071 ABC-ATPase subunit interface; other site 930781001072 Uncharacterized conserved protein [Function unknown]; Region: COG3538 930781001073 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 930781001074 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 930781001075 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930781001076 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 930781001077 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930781001078 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930781001079 putative active site [active] 930781001080 putative metal binding site [ion binding]; other site 930781001081 GTPases [General function prediction only]; Region: HflX; COG2262 930781001082 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930781001083 HflX GTPase family; Region: HflX; cd01878 930781001084 G1 box; other site 930781001085 GTP/Mg2+ binding site [chemical binding]; other site 930781001086 Switch I region; other site 930781001087 G2 box; other site 930781001088 G3 box; other site 930781001089 Switch II region; other site 930781001090 G4 box; other site 930781001091 G5 box; other site 930781001092 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 930781001093 Predicted esterase [General function prediction only]; Region: COG0400 930781001094 putative hydrolase; Provisional; Region: PRK11460 930781001095 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930781001096 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781001097 Zn binding site [ion binding]; other site 930781001098 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930781001099 Zn binding site [ion binding]; other site 930781001100 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930781001101 Zn binding site [ion binding]; other site 930781001102 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930781001103 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781001104 Zn binding site [ion binding]; other site 930781001105 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 930781001106 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930781001107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781001108 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781001109 Walker A/P-loop; other site 930781001110 ATP binding site [chemical binding]; other site 930781001111 Q-loop/lid; other site 930781001112 ABC transporter signature motif; other site 930781001113 Walker B; other site 930781001114 D-loop; other site 930781001115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930781001116 H-loop/switch region; other site 930781001117 active site 930781001118 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 930781001119 active site 930781001120 catalytic triad [active] 930781001121 oxyanion hole [active] 930781001122 SnoaL-like domain; Region: SnoaL_4; pfam13577 930781001123 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781001124 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930781001125 ligand binding site [chemical binding]; other site 930781001126 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930781001127 non-specific DNA interactions [nucleotide binding]; other site 930781001128 DNA binding site [nucleotide binding] 930781001129 sequence specific DNA binding site [nucleotide binding]; other site 930781001130 putative cAMP binding site [chemical binding]; other site 930781001131 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930781001132 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781001133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781001134 Walker A/P-loop; other site 930781001135 ATP binding site [chemical binding]; other site 930781001136 Q-loop/lid; other site 930781001137 ABC transporter signature motif; other site 930781001138 Walker B; other site 930781001139 D-loop; other site 930781001140 H-loop/switch region; other site 930781001141 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781001142 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930781001143 FtsX-like permease family; Region: FtsX; pfam02687 930781001144 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930781001145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781001146 Walker A/P-loop; other site 930781001147 ATP binding site [chemical binding]; other site 930781001148 Q-loop/lid; other site 930781001149 ABC transporter signature motif; other site 930781001150 Walker B; other site 930781001151 D-loop; other site 930781001152 H-loop/switch region; other site 930781001153 Predicted transcriptional regulators [Transcription]; Region: COG1725 930781001154 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001155 DNA-binding site [nucleotide binding]; DNA binding site 930781001156 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781001157 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781001158 ligand binding site [chemical binding]; other site 930781001159 flexible hinge region; other site 930781001160 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930781001161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781001162 non-specific DNA binding site [nucleotide binding]; other site 930781001163 salt bridge; other site 930781001164 sequence-specific DNA binding site [nucleotide binding]; other site 930781001165 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 930781001166 GIY-YIG motif/motif A; other site 930781001167 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 930781001168 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930781001169 active site 930781001170 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 930781001171 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 930781001172 glutaminase active site [active] 930781001173 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930781001174 dimer interface [polypeptide binding]; other site 930781001175 active site 930781001176 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930781001177 dimer interface [polypeptide binding]; other site 930781001178 active site 930781001179 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930781001180 putative active site [active] 930781001181 pyruvate oxidase; Provisional; Region: PRK08611 930781001182 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 930781001183 PYR/PP interface [polypeptide binding]; other site 930781001184 dimer interface [polypeptide binding]; other site 930781001185 tetramer interface [polypeptide binding]; other site 930781001186 TPP binding site [chemical binding]; other site 930781001187 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930781001188 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 930781001189 TPP-binding site [chemical binding]; other site 930781001190 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 930781001191 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 930781001192 Predicted transcriptional regulators [Transcription]; Region: COG1695 930781001193 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930781001194 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 930781001195 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930781001196 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930781001197 catalytic residue [active] 930781001198 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 930781001199 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930781001200 Walker A motif; other site 930781001201 ATP binding site [chemical binding]; other site 930781001202 Walker B motif; other site 930781001203 flagellar assembly protein H; Validated; Region: fliH; PRK06800 930781001204 Flagellar assembly protein FliH; Region: FliH; pfam02108 930781001205 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 930781001206 FliG C-terminal domain; Region: FliG_C; pfam01706 930781001207 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 930781001208 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 930781001209 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 930781001210 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 930781001211 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 930781001212 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930781001213 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 930781001214 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 930781001215 flagellar capping protein; Validated; Region: fliD; PRK06798 930781001216 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 930781001217 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 930781001218 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 930781001219 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930781001220 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 930781001221 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930781001222 Protein of unknown function (DUF327); Region: DUF327; pfam03885 930781001223 flagellar motor switch protein; Reviewed; Region: PRK06782 930781001224 CheC-like family; Region: CheC; pfam04509 930781001225 CheC-like family; Region: CheC; pfam04509 930781001226 Chemotaxis phosphatase CheX; Region: CheX; cl15816 930781001227 CheC-like family; Region: CheC; pfam04509 930781001228 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 930781001229 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 930781001230 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 930781001231 flagellar motor switch protein; Validated; Region: PRK06789 930781001232 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 930781001233 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 930781001234 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 930781001235 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930781001236 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 930781001237 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 930781001238 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 930781001239 flagellar motor switch protein; Validated; Region: PRK06788 930781001240 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 930781001241 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 930781001242 putative binding surface; other site 930781001243 active site 930781001244 P2 response regulator binding domain; Region: P2; pfam07194 930781001245 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 930781001246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781001247 ATP binding site [chemical binding]; other site 930781001248 Mg2+ binding site [ion binding]; other site 930781001249 G-X-G motif; other site 930781001250 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 930781001251 Response regulator receiver domain; Region: Response_reg; pfam00072 930781001252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781001253 active site 930781001254 phosphorylation site [posttranslational modification] 930781001255 intermolecular recognition site; other site 930781001256 dimerization interface [polypeptide binding]; other site 930781001257 flagellin; Provisional; Region: PRK12805 930781001258 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930781001259 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 930781001260 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 930781001261 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 930781001262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781001263 active site 930781001264 phosphorylation site [posttranslational modification] 930781001265 intermolecular recognition site; other site 930781001266 dimerization interface [polypeptide binding]; other site 930781001267 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930781001268 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 930781001269 putative metal binding site; other site 930781001270 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781001271 binding surface 930781001272 TPR motif; other site 930781001273 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 930781001274 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 930781001275 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 930781001276 ligand binding site [chemical binding]; other site 930781001277 flagellar motor protein MotA; Validated; Region: PRK08124 930781001278 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 930781001279 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 930781001280 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 930781001281 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 930781001282 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 930781001283 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 930781001284 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930781001285 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 930781001286 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930781001287 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 930781001288 FHIPEP family; Region: FHIPEP; pfam00771 930781001289 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 930781001290 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 930781001291 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 930781001292 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 930781001293 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 930781001294 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 930781001295 Predicted membrane protein [Function unknown]; Region: COG3152 930781001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 930781001297 oxidoreductase; Provisional; Region: PRK07985 930781001298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930781001299 NAD(P) binding site [chemical binding]; other site 930781001300 active site 930781001301 inner membrane transport permease; Provisional; Region: PRK15066 930781001302 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930781001303 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781001304 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 930781001305 Walker A/P-loop; other site 930781001306 ATP binding site [chemical binding]; other site 930781001307 Q-loop/lid; other site 930781001308 ABC transporter signature motif; other site 930781001309 Walker B; other site 930781001310 D-loop; other site 930781001311 H-loop/switch region; other site 930781001312 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 930781001313 maltose O-acetyltransferase; Provisional; Region: PRK10092 930781001314 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 930781001315 active site 930781001316 substrate binding site [chemical binding]; other site 930781001317 trimer interface [polypeptide binding]; other site 930781001318 CoA binding site [chemical binding]; other site 930781001319 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781001320 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001321 active site 930781001322 motif I; other site 930781001323 motif II; other site 930781001324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001325 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930781001326 dimer interface [polypeptide binding]; other site 930781001327 substrate binding site [chemical binding]; other site 930781001328 ATP binding site [chemical binding]; other site 930781001329 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 930781001330 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001331 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781001332 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781001333 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930781001334 Transposase; Region: HTH_Tnp_1; cl17663 930781001335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781001336 non-specific DNA binding site [nucleotide binding]; other site 930781001337 salt bridge; other site 930781001338 sequence-specific DNA binding site [nucleotide binding]; other site 930781001339 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930781001340 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 930781001341 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930781001342 minor groove reading motif; other site 930781001343 helix-hairpin-helix signature motif; other site 930781001344 substrate binding pocket [chemical binding]; other site 930781001345 active site 930781001346 Predicted membrane protein [Function unknown]; Region: COG2322 930781001347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930781001348 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 930781001349 active site 930781001350 metal binding site [ion binding]; metal-binding site 930781001351 Predicted integral membrane protein [Function unknown]; Region: COG5523 930781001352 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930781001353 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930781001354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001355 DNA-binding site [nucleotide binding]; DNA binding site 930781001356 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930781001357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001358 DNA-binding site [nucleotide binding]; DNA binding site 930781001359 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930781001360 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930781001361 Cl binding site [ion binding]; other site 930781001362 oligomer interface [polypeptide binding]; other site 930781001363 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 930781001364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 930781001365 putative metal binding site [ion binding]; other site 930781001366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930781001367 active site 930781001368 amino acid transporter; Region: 2A0306; TIGR00909 930781001369 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930781001370 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930781001371 Sulfatase; Region: Sulfatase; pfam00884 930781001372 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 930781001373 catalytic residue [active] 930781001374 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 930781001375 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781001376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001377 motif II; other site 930781001378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781001379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781001380 active site 930781001381 catalytic tetrad [active] 930781001382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781001383 S-adenosylmethionine binding site [chemical binding]; other site 930781001384 Predicted transcriptional regulator [Transcription]; Region: COG1959 930781001385 Transcriptional regulator; Region: Rrf2; pfam02082 930781001386 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 930781001387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001388 motif II; other site 930781001389 Isochorismatase family; Region: Isochorismatase; pfam00857 930781001390 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930781001391 catalytic triad [active] 930781001392 conserved cis-peptide bond; other site 930781001393 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930781001394 domain interaction interfaces [polypeptide binding]; other site 930781001395 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930781001396 domain interaction interfaces [polypeptide binding]; other site 930781001397 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930781001398 domain interaction interfaces [polypeptide binding]; other site 930781001399 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930781001400 domain interaction interfaces [polypeptide binding]; other site 930781001401 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 930781001402 active site 930781001403 catalytic triad [active] 930781001404 oxyanion hole [active] 930781001405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930781001406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781001407 Coenzyme A binding pocket [chemical binding]; other site 930781001408 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930781001409 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930781001410 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 930781001411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930781001412 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930781001413 active site 930781001414 ATP binding site [chemical binding]; other site 930781001415 substrate binding site [chemical binding]; other site 930781001416 activation loop (A-loop); other site 930781001417 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 930781001418 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930781001419 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 930781001420 putative active site [active] 930781001421 catalytic site [active] 930781001422 putative metal binding site [ion binding]; other site 930781001423 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 930781001424 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930781001425 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930781001426 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 930781001427 putative NAD(P) binding site [chemical binding]; other site 930781001428 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930781001429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781001430 putative DNA binding site [nucleotide binding]; other site 930781001431 putative Zn2+ binding site [ion binding]; other site 930781001432 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930781001433 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930781001434 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001435 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930781001436 active site residue [active] 930781001437 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781001438 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781001439 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930781001440 Walker A/P-loop; other site 930781001441 ATP binding site [chemical binding]; other site 930781001442 Q-loop/lid; other site 930781001443 ABC transporter signature motif; other site 930781001444 Walker B; other site 930781001445 D-loop; other site 930781001446 H-loop/switch region; other site 930781001447 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781001448 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781001449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781001450 Walker A/P-loop; other site 930781001451 ATP binding site [chemical binding]; other site 930781001452 Q-loop/lid; other site 930781001453 ABC transporter signature motif; other site 930781001454 Walker B; other site 930781001455 D-loop; other site 930781001456 H-loop/switch region; other site 930781001457 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930781001458 MarR family; Region: MarR_2; pfam12802 930781001459 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 930781001460 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930781001461 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930781001462 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930781001463 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930781001464 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930781001465 Predicted membrane protein [Function unknown]; Region: COG4709 930781001466 Predicted transcriptional regulators [Transcription]; Region: COG1695 930781001467 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930781001468 BioY family; Region: BioY; pfam02632 930781001469 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781001470 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930781001471 ligand binding site [chemical binding]; other site 930781001472 flexible hinge region; other site 930781001473 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930781001474 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 930781001475 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 930781001476 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930781001477 homodimer interface [polypeptide binding]; other site 930781001478 substrate-cofactor binding pocket; other site 930781001479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781001480 catalytic residue [active] 930781001481 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 930781001482 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 930781001483 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 930781001484 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 930781001485 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 930781001486 DAK2 domain; Region: Dak2; pfam02734 930781001487 EDD domain protein, DegV family; Region: DegV; TIGR00762 930781001488 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930781001489 Predicted membrane protein [Function unknown]; Region: COG4852 930781001490 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 930781001491 DNA photolyase; Region: DNA_photolyase; pfam00875 930781001492 UreD urease accessory protein; Region: UreD; cl00530 930781001493 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 930781001494 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 930781001495 WxL domain surface cell wall-binding; Region: WxL; pfam13731 930781001496 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930781001497 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930781001498 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 930781001499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930781001500 ATP binding site [chemical binding]; other site 930781001501 putative Mg++ binding site [ion binding]; other site 930781001502 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930781001503 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 930781001504 nucleotide binding region [chemical binding]; other site 930781001505 ATP-binding site [chemical binding]; other site 930781001506 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 930781001507 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 930781001508 putative RNA binding site [nucleotide binding]; other site 930781001509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781001510 S-adenosylmethionine binding site [chemical binding]; other site 930781001511 Predicted esterase [General function prediction only]; Region: COG0400 930781001512 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 930781001513 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 930781001514 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781001515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781001516 DNA-binding site [nucleotide binding]; DNA binding site 930781001517 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930781001518 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781001519 beta-galactosidase; Region: BGL; TIGR03356 930781001520 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930781001521 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930781001522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930781001523 DNA binding site [nucleotide binding] 930781001524 active site 930781001525 histidinol-phosphatase; Reviewed; Region: PRK08123 930781001526 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 930781001527 active site 930781001528 dimer interface [polypeptide binding]; other site 930781001529 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 930781001530 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930781001531 dimer interface [polypeptide binding]; other site 930781001532 motif 1; other site 930781001533 active site 930781001534 motif 2; other site 930781001535 motif 3; other site 930781001536 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 930781001537 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 930781001538 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 930781001539 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 930781001540 NAD binding site [chemical binding]; other site 930781001541 dimerization interface [polypeptide binding]; other site 930781001542 product binding site; other site 930781001543 substrate binding site [chemical binding]; other site 930781001544 zinc binding site [ion binding]; other site 930781001545 catalytic residues [active] 930781001546 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 930781001547 putative active site pocket [active] 930781001548 4-fold oligomerization interface [polypeptide binding]; other site 930781001549 metal binding residues [ion binding]; metal-binding site 930781001550 3-fold/trimer interface [polypeptide binding]; other site 930781001551 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 930781001552 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 930781001553 putative active site [active] 930781001554 oxyanion strand; other site 930781001555 catalytic triad [active] 930781001556 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 930781001557 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 930781001558 catalytic residues [active] 930781001559 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 930781001560 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 930781001561 substrate binding site [chemical binding]; other site 930781001562 glutamase interaction surface [polypeptide binding]; other site 930781001563 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 930781001564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 930781001565 metal binding site [ion binding]; metal-binding site 930781001566 glutamate dehydrogenase; Provisional; Region: PRK09414 930781001567 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 930781001568 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 930781001569 NAD(P) binding site [chemical binding]; other site 930781001570 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 930781001571 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930781001572 Cl binding site [ion binding]; other site 930781001573 oligomer interface [polypeptide binding]; other site 930781001574 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 930781001575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001576 catalytic core [active] 930781001577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001578 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001579 catalytic core [active] 930781001580 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001581 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 930781001582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781001583 putative substrate translocation pore; other site 930781001584 POT family; Region: PTR2; pfam00854 930781001585 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 930781001586 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 930781001587 dimer interface [polypeptide binding]; other site 930781001588 active site 930781001589 metal binding site [ion binding]; metal-binding site 930781001590 FOG: CBS domain [General function prediction only]; Region: COG0517 930781001591 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 930781001592 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 930781001593 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 930781001594 WxL domain surface cell wall-binding; Region: WxL; pfam13731 930781001595 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781001596 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 930781001597 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001598 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001599 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001600 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930781001601 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930781001602 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 930781001603 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781001604 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 930781001605 Glucitol operon activator protein (GutM); Region: GutM; cl01890 930781001606 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 930781001607 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 930781001608 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 930781001609 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 930781001610 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 930781001611 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930781001612 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930781001613 intersubunit interface [polypeptide binding]; other site 930781001614 Beta-lactamase; Region: Beta-lactamase; pfam00144 930781001615 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930781001616 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 930781001617 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930781001618 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 930781001619 metal binding site [ion binding]; metal-binding site 930781001620 putative dimer interface [polypeptide binding]; other site 930781001621 allantoate amidohydrolase; Reviewed; Region: PRK09290 930781001622 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 930781001623 active site 930781001624 metal binding site [ion binding]; metal-binding site 930781001625 dimer interface [polypeptide binding]; other site 930781001626 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930781001627 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 930781001628 NAD binding site [chemical binding]; other site 930781001629 sugar binding site [chemical binding]; other site 930781001630 divalent metal binding site [ion binding]; other site 930781001631 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781001632 dimer interface [polypeptide binding]; other site 930781001633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781001634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781001635 DNA binding site [nucleotide binding] 930781001636 domain linker motif; other site 930781001637 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930781001638 putative dimerization interface [polypeptide binding]; other site 930781001639 putative ligand binding site [chemical binding]; other site 930781001640 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 930781001641 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 930781001642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781001643 S-adenosylmethionine binding site [chemical binding]; other site 930781001644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930781001645 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 930781001646 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 930781001647 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930781001648 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930781001649 DXD motif; other site 930781001650 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 930781001651 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 930781001652 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930781001653 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930781001654 DNA binding residues [nucleotide binding] 930781001655 dimer interface [polypeptide binding]; other site 930781001656 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930781001657 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 930781001658 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930781001659 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930781001660 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930781001661 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781001662 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781001663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781001664 putative active site [active] 930781001665 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930781001666 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 930781001667 NAD binding site [chemical binding]; other site 930781001668 sugar binding site [chemical binding]; other site 930781001669 divalent metal binding site [ion binding]; other site 930781001670 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781001671 dimer interface [polypeptide binding]; other site 930781001672 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930781001673 non-specific DNA interactions [nucleotide binding]; other site 930781001674 DNA binding site [nucleotide binding] 930781001675 sequence specific DNA binding site [nucleotide binding]; other site 930781001676 putative cAMP binding site [chemical binding]; other site 930781001677 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781001678 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930781001679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781001680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781001681 putative substrate translocation pore; other site 930781001682 Predicted membrane protein [Function unknown]; Region: COG3759 930781001683 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001684 catalytic core [active] 930781001685 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781001686 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 930781001687 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930781001688 putative active site [active] 930781001689 putative metal binding site [ion binding]; other site 930781001690 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930781001691 Ligand Binding Site [chemical binding]; other site 930781001692 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001693 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781001694 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781001695 MarR family; Region: MarR_2; pfam12802 930781001696 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 930781001697 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 930781001698 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 930781001699 catalytic triad [active] 930781001700 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930781001701 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 930781001702 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930781001703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781001704 active site 930781001705 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930781001706 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930781001707 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 930781001708 active site 930781001709 P-loop; other site 930781001710 phosphorylation site [posttranslational modification] 930781001711 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930781001712 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 930781001713 putative NAD(P) binding site [chemical binding]; other site 930781001714 catalytic Zn binding site [ion binding]; other site 930781001715 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930781001716 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930781001717 substrate binding site [chemical binding]; other site 930781001718 hexamer interface [polypeptide binding]; other site 930781001719 metal binding site [ion binding]; metal-binding site 930781001720 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781001721 active site 930781001722 phosphorylation site [posttranslational modification] 930781001723 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 930781001724 putative active site [active] 930781001725 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781001726 PRD domain; Region: PRD; pfam00874 930781001727 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781001728 active site 930781001729 P-loop; other site 930781001730 phosphorylation site [posttranslational modification] 930781001731 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781001732 active site 930781001733 phosphorylation site [posttranslational modification] 930781001734 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 930781001735 catalytic residue [active] 930781001736 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930781001737 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930781001738 substrate binding site [chemical binding]; other site 930781001739 hexamer interface [polypeptide binding]; other site 930781001740 metal binding site [ion binding]; metal-binding site 930781001741 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930781001742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 930781001743 EamA-like transporter family; Region: EamA; pfam00892 930781001744 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930781001745 EamA-like transporter family; Region: EamA; pfam00892 930781001746 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 930781001747 active site 930781001748 catalytic triad [active] 930781001749 oxyanion hole [active] 930781001750 Predicted acyl esterases [General function prediction only]; Region: COG2936 930781001751 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 930781001752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781001753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781001754 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 930781001755 dimerization interface [polypeptide binding]; other site 930781001756 substrate binding pocket [chemical binding]; other site 930781001757 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 930781001758 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 930781001759 active site 930781001760 catalytic residue [active] 930781001761 dimer interface [polypeptide binding]; other site 930781001762 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 930781001763 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930781001764 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930781001765 shikimate binding site; other site 930781001766 NAD(P) binding site [chemical binding]; other site 930781001767 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930781001768 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 930781001769 active site 930781001770 FMN binding site [chemical binding]; other site 930781001771 substrate binding site [chemical binding]; other site 930781001772 putative catalytic residue [active] 930781001773 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930781001774 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781001775 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781001776 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781001777 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781001778 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930781001779 putative dimerization interface [polypeptide binding]; other site 930781001780 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930781001781 nudix motif; other site 930781001782 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 930781001783 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 930781001784 putative FMN binding site [chemical binding]; other site 930781001785 LXG domain of WXG superfamily; Region: LXG; pfam04740 930781001786 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 930781001787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 930781001788 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 930781001789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930781001790 FeS/SAM binding site; other site 930781001791 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 930781001792 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930781001793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781001794 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 930781001795 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 930781001796 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781001797 Zn2+ binding site [ion binding]; other site 930781001798 Mg2+ binding site [ion binding]; other site 930781001799 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781001800 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001801 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001802 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001803 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001804 Leucine rich repeat; Region: LRR_8; pfam13855 930781001805 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001806 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781001807 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001808 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001809 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001810 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781001811 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001812 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001813 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001814 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001815 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001816 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001817 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781001818 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001819 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001820 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001821 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001822 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001823 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781001824 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001825 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001826 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001827 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781001828 Leucine rich repeat; Region: LRR_8; pfam13855 930781001829 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001830 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781001831 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 930781001832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781001833 nucleotide binding site [chemical binding]; other site 930781001834 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 930781001835 Uncharacterized conserved protein [Function unknown]; Region: COG3535 930781001836 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 930781001837 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930781001838 Na binding site [ion binding]; other site 930781001839 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 930781001840 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930781001841 MoxR-like ATPases [General function prediction only]; Region: COG0714 930781001842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781001843 Walker A motif; other site 930781001844 ATP binding site [chemical binding]; other site 930781001845 Walker B motif; other site 930781001846 arginine finger; other site 930781001847 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930781001848 Protein of unknown function DUF58; Region: DUF58; pfam01882 930781001849 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930781001850 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930781001851 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930781001852 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 930781001853 Predicted membrane protein [Function unknown]; Region: COG3619 930781001854 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 930781001855 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 930781001856 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930781001857 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 930781001858 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 930781001859 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930781001860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930781001861 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 930781001862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930781001863 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 930781001864 NAD(P) binding site [chemical binding]; other site 930781001865 active site 930781001866 Predicted transcriptional regulator [Transcription]; Region: COG1959 930781001867 Transcriptional regulator; Region: Rrf2; pfam02082 930781001868 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781001869 Leucine rich repeat; Region: LRR_8; pfam13855 930781001870 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781001871 Leucine rich repeat; Region: LRR_8; pfam13855 930781001872 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001873 LRR adjacent; Region: LRR_adjacent; pfam08191 930781001874 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 930781001875 SH3-like domain; Region: SH3_8; pfam13457 930781001876 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781001877 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001878 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781001879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001881 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001882 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001883 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001885 LRR adjacent; Region: LRR_adjacent; pfam08191 930781001886 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001887 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001888 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001889 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 930781001890 RHS protein; Region: RHS; pfam03527 930781001891 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 930781001892 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 930781001893 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 930781001894 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 930781001895 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 930781001896 RHS Repeat; Region: RHS_repeat; pfam05593 930781001897 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 930781001898 RHS Repeat; Region: RHS_repeat; pfam05593 930781001899 RHS Repeat; Region: RHS_repeat; pfam05593 930781001900 RHS Repeat; Region: RHS_repeat; pfam05593 930781001901 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 930781001902 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930781001903 classical (c) SDRs; Region: SDR_c; cd05233 930781001904 NAD(P) binding site [chemical binding]; other site 930781001905 active site 930781001906 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 930781001907 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930781001908 active site 930781001909 substrate binding site [chemical binding]; other site 930781001910 trimer interface [polypeptide binding]; other site 930781001911 CoA binding site [chemical binding]; other site 930781001912 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781001913 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781001914 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930781001915 dimerization interface [polypeptide binding]; other site 930781001916 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930781001917 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930781001918 active site 930781001919 metal binding site [ion binding]; metal-binding site 930781001920 catalytic site [active] 930781001921 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 930781001922 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930781001923 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930781001924 active site 930781001925 P-loop; other site 930781001926 phosphorylation site [posttranslational modification] 930781001927 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781001928 active site 930781001929 phosphorylation site [posttranslational modification] 930781001930 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930781001931 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781001932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001933 active site 930781001934 motif I; other site 930781001935 motif II; other site 930781001936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781001937 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 930781001938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781001939 non-specific DNA binding site [nucleotide binding]; other site 930781001940 salt bridge; other site 930781001941 sequence-specific DNA binding site [nucleotide binding]; other site 930781001942 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930781001943 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 930781001944 NodB motif; other site 930781001945 active site 930781001946 catalytic site [active] 930781001947 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 930781001948 ZIP Zinc transporter; Region: Zip; pfam02535 930781001949 phosphoenolpyruvate synthase; Validated; Region: PRK06241 930781001950 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930781001951 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930781001952 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781001953 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001954 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781001955 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001956 Leucine-rich repeats; other site 930781001957 Substrate binding site [chemical binding]; other site 930781001958 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001959 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001960 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001961 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781001962 LRR adjacent; Region: LRR_adjacent; pfam08191 930781001963 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001964 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001965 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001966 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781001967 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781001968 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 930781001969 trimer interface [polypeptide binding]; other site 930781001970 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 930781001971 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 930781001972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781001973 putative metal binding site [ion binding]; other site 930781001974 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930781001975 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781001976 HTH domain; Region: HTH_11; pfam08279 930781001977 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781001978 PRD domain; Region: PRD; pfam00874 930781001979 PRD domain; Region: PRD; pfam00874 930781001980 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781001981 active site 930781001982 P-loop; other site 930781001983 phosphorylation site [posttranslational modification] 930781001984 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781001985 active site 930781001986 phosphorylation site [posttranslational modification] 930781001987 alpha-mannosidase; Provisional; Region: PRK09819 930781001988 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930781001989 active site 930781001990 metal binding site [ion binding]; metal-binding site 930781001991 catalytic site [active] 930781001992 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930781001993 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930781001994 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930781001995 active site 930781001996 P-loop; other site 930781001997 phosphorylation site [posttranslational modification] 930781001998 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781001999 active site 930781002000 phosphorylation site [posttranslational modification] 930781002001 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 930781002002 putative hydrophobic ligand binding site [chemical binding]; other site 930781002003 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781002004 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930781002005 FtsX-like permease family; Region: FtsX; pfam02687 930781002006 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781002007 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781002008 Walker A/P-loop; other site 930781002009 ATP binding site [chemical binding]; other site 930781002010 Q-loop/lid; other site 930781002011 ABC transporter signature motif; other site 930781002012 Walker B; other site 930781002013 D-loop; other site 930781002014 H-loop/switch region; other site 930781002015 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930781002016 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930781002017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781002018 DNA-binding site [nucleotide binding]; DNA binding site 930781002019 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930781002020 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781002021 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 930781002022 pyrroline-5-carboxylate reductase; Region: PLN02688 930781002023 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781002024 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781002025 Coenzyme A binding pocket [chemical binding]; other site 930781002026 Bacterial SH3 domain; Region: SH3_3; cl17532 930781002027 NlpC/P60 family; Region: NLPC_P60; pfam00877 930781002028 hypothetical protein; Provisional; Region: PRK13665 930781002029 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 930781002030 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930781002031 ligand binding site [chemical binding]; other site 930781002032 active site 930781002033 UGI interface [polypeptide binding]; other site 930781002034 catalytic site [active] 930781002035 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 930781002036 Uncharacterized conserved protein [Function unknown]; Region: COG5646 930781002037 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 930781002038 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930781002039 PYR/PP interface [polypeptide binding]; other site 930781002040 dimer interface [polypeptide binding]; other site 930781002041 TPP binding site [chemical binding]; other site 930781002042 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930781002043 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 930781002044 TPP-binding site; other site 930781002045 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930781002046 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 930781002047 substrate binding site [chemical binding]; other site 930781002048 ATP binding site [chemical binding]; other site 930781002049 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 930781002050 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781002051 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930781002052 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781002053 Predicted transcriptional regulator [Transcription]; Region: COG2378 930781002054 HTH domain; Region: HTH_11; pfam08279 930781002055 WYL domain; Region: WYL; pfam13280 930781002056 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781002057 active site 930781002058 P-loop; other site 930781002059 phosphorylation site [posttranslational modification] 930781002060 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781002061 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 930781002062 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781002063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781002064 DNA-binding site [nucleotide binding]; DNA binding site 930781002065 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930781002066 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 930781002067 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 930781002068 PhnA protein; Region: PhnA; pfam03831 930781002069 hypothetical protein; Provisional; Region: PRK12378 930781002070 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 930781002071 nudix motif; other site 930781002072 Predicted transcriptional regulator [Transcription]; Region: COG2378 930781002073 HTH domain; Region: HTH_11; pfam08279 930781002074 WYL domain; Region: WYL; pfam13280 930781002075 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930781002076 conserved cys residue [active] 930781002077 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781002078 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 930781002079 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781002080 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930781002081 intersubunit interface [polypeptide binding]; other site 930781002082 active site 930781002083 zinc binding site [ion binding]; other site 930781002084 Na+ binding site [ion binding]; other site 930781002085 putative oxidoreductase; Provisional; Region: PRK10206 930781002086 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781002087 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930781002088 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 930781002089 L-aspartate oxidase; Provisional; Region: PRK06175 930781002090 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 930781002091 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930781002092 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930781002093 acyl-activating enzyme (AAE) consensus motif; other site 930781002094 acyl-activating enzyme (AAE) consensus motif; other site 930781002095 AMP binding site [chemical binding]; other site 930781002096 active site 930781002097 CoA binding site [chemical binding]; other site 930781002098 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781002099 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930781002100 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002101 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002102 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781002104 Coenzyme A binding pocket [chemical binding]; other site 930781002105 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781002106 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781002107 putative DNA binding site [nucleotide binding]; other site 930781002108 putative Zn2+ binding site [ion binding]; other site 930781002109 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781002110 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 930781002111 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 930781002112 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930781002113 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930781002114 DAK2 domain; Region: Dak2; cl03685 930781002115 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930781002116 substrate binding site [chemical binding]; other site 930781002117 dimer interface [polypeptide binding]; other site 930781002118 catalytic triad [active] 930781002119 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930781002120 short chain dehydrogenase; Provisional; Region: PRK06841 930781002121 classical (c) SDRs; Region: SDR_c; cd05233 930781002122 NAD(P) binding site [chemical binding]; other site 930781002123 active site 930781002124 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930781002125 active site 930781002126 intersubunit interactions; other site 930781002127 catalytic residue [active] 930781002128 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930781002129 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930781002130 TPP-binding site [chemical binding]; other site 930781002131 dimer interface [polypeptide binding]; other site 930781002132 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930781002133 PYR/PP interface [polypeptide binding]; other site 930781002134 dimer interface [polypeptide binding]; other site 930781002135 TPP binding site [chemical binding]; other site 930781002136 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781002137 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 930781002138 LXG domain of WXG superfamily; Region: LXG; pfam04740 930781002139 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 930781002140 Leucine rich repeat; Region: LRR_8; pfam13855 930781002141 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002142 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002143 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002144 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002145 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781002146 Leucine rich repeat; Region: LRR_8; pfam13855 930781002147 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002148 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002149 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002150 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002151 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002152 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002153 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002154 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002155 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002156 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002157 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002158 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002159 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002160 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781002162 non-specific DNA binding site [nucleotide binding]; other site 930781002163 salt bridge; other site 930781002164 sequence-specific DNA binding site [nucleotide binding]; other site 930781002165 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930781002166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781002167 non-specific DNA binding site [nucleotide binding]; other site 930781002168 salt bridge; other site 930781002169 sequence-specific DNA binding site [nucleotide binding]; other site 930781002170 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930781002171 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 930781002172 putative catalytic site [active] 930781002173 putative metal binding site [ion binding]; other site 930781002174 putative phosphate binding site [ion binding]; other site 930781002175 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 930781002176 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 930781002177 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781002178 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781002179 beta-galactosidase; Region: BGL; TIGR03356 930781002180 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 930781002181 thiamine phosphate binding site [chemical binding]; other site 930781002182 active site 930781002183 pyrophosphate binding site [ion binding]; other site 930781002184 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930781002185 dimer interface [polypeptide binding]; other site 930781002186 substrate binding site [chemical binding]; other site 930781002187 ATP binding site [chemical binding]; other site 930781002188 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 930781002189 substrate binding site [chemical binding]; other site 930781002190 multimerization interface [polypeptide binding]; other site 930781002191 ATP binding site [chemical binding]; other site 930781002192 Putative transcription activator [Transcription]; Region: TenA; COG0819 930781002193 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 930781002194 putative active site [active] 930781002195 YdjC motif; other site 930781002196 Mg binding site [ion binding]; other site 930781002197 putative homodimer interface [polypeptide binding]; other site 930781002198 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930781002199 active site 930781002200 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 930781002201 nucleophilic elbow; other site 930781002202 catalytic triad; other site 930781002203 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 930781002204 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 930781002205 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930781002206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781002207 catalytic residue [active] 930781002208 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 930781002209 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 930781002210 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781002211 methionine cluster; other site 930781002212 active site 930781002213 phosphorylation site [posttranslational modification] 930781002214 metal binding site [ion binding]; metal-binding site 930781002215 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781002216 beta-galactosidase; Region: BGL; TIGR03356 930781002217 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781002218 active site 930781002219 P-loop; other site 930781002220 phosphorylation site [posttranslational modification] 930781002221 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781002222 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781002223 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781002224 HTH domain; Region: HTH_11; pfam08279 930781002225 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781002226 PRD domain; Region: PRD; pfam00874 930781002227 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781002228 active site 930781002229 P-loop; other site 930781002230 phosphorylation site [posttranslational modification] 930781002231 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781002232 active site 930781002233 phosphorylation site [posttranslational modification] 930781002234 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930781002235 dimer interface [polypeptide binding]; other site 930781002236 FMN binding site [chemical binding]; other site 930781002237 NADPH bind site [chemical binding]; other site 930781002238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781002239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781002240 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930781002241 dimerization interface [polypeptide binding]; other site 930781002242 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 930781002243 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930781002244 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930781002245 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930781002246 protein binding site [polypeptide binding]; other site 930781002247 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 930781002248 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930781002249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 930781002250 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 930781002251 YycH protein; Region: YycH; pfam07435 930781002252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 930781002253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930781002254 dimerization interface [polypeptide binding]; other site 930781002255 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930781002256 putative active site [active] 930781002257 heme pocket [chemical binding]; other site 930781002258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781002259 dimer interface [polypeptide binding]; other site 930781002260 phosphorylation site [posttranslational modification] 930781002261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781002262 ATP binding site [chemical binding]; other site 930781002263 Mg2+ binding site [ion binding]; other site 930781002264 G-X-G motif; other site 930781002265 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781002266 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781002267 active site 930781002268 phosphorylation site [posttranslational modification] 930781002269 intermolecular recognition site; other site 930781002270 dimerization interface [polypeptide binding]; other site 930781002271 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781002272 DNA binding site [nucleotide binding] 930781002273 transaminase; Reviewed; Region: PRK08068 930781002274 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781002275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781002276 homodimer interface [polypeptide binding]; other site 930781002277 catalytic residue [active] 930781002278 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930781002279 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930781002280 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 930781002281 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930781002282 Walker A/P-loop; other site 930781002283 ATP binding site [chemical binding]; other site 930781002284 Q-loop/lid; other site 930781002285 ABC transporter signature motif; other site 930781002286 Walker B; other site 930781002287 D-loop; other site 930781002288 H-loop/switch region; other site 930781002289 NIL domain; Region: NIL; pfam09383 930781002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002291 dimer interface [polypeptide binding]; other site 930781002292 conserved gate region; other site 930781002293 ABC-ATPase subunit interface; other site 930781002294 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930781002295 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 930781002296 putative active site [active] 930781002297 catalytic triad [active] 930781002298 putative dimer interface [polypeptide binding]; other site 930781002299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781002300 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781002301 ligand binding site [chemical binding]; other site 930781002302 flexible hinge region; other site 930781002303 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 930781002304 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 930781002305 ATP cone domain; Region: ATP-cone; pfam03477 930781002306 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 930781002307 Class III ribonucleotide reductase; Region: RNR_III; cd01675 930781002308 effector binding site; other site 930781002309 active site 930781002310 Zn binding site [ion binding]; other site 930781002311 glycine loop; other site 930781002312 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930781002313 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930781002314 Walker A/P-loop; other site 930781002315 ATP binding site [chemical binding]; other site 930781002316 Q-loop/lid; other site 930781002317 ABC transporter signature motif; other site 930781002318 Walker B; other site 930781002319 D-loop; other site 930781002320 H-loop/switch region; other site 930781002321 TOBE domain; Region: TOBE; pfam03459 930781002322 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781002323 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781002324 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930781002325 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930781002326 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930781002327 active site 930781002328 motif I; other site 930781002329 motif II; other site 930781002330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002331 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930781002332 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930781002333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781002334 Coenzyme A binding pocket [chemical binding]; other site 930781002335 sugar phosphate phosphatase; Provisional; Region: PRK10513 930781002336 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002337 active site 930781002338 motif I; other site 930781002339 motif II; other site 930781002340 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002341 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781002342 beta-galactosidase; Region: BGL; TIGR03356 930781002343 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 930781002344 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781002345 Substrate binding site [chemical binding]; other site 930781002346 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002347 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002348 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002349 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002350 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002351 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 930781002352 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930781002353 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930781002354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002355 dimer interface [polypeptide binding]; other site 930781002356 conserved gate region; other site 930781002357 ABC-ATPase subunit interface; other site 930781002358 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930781002359 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781002360 Zn binding site [ion binding]; other site 930781002361 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930781002362 Zn binding site [ion binding]; other site 930781002363 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781002364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781002365 putative Zn2+ binding site [ion binding]; other site 930781002366 putative DNA binding site [nucleotide binding]; other site 930781002367 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 930781002368 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 930781002369 metal binding site [ion binding]; metal-binding site 930781002370 dimer interface [polypeptide binding]; other site 930781002371 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781002372 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002373 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781002374 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002375 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002376 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002377 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002378 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002379 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002380 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002381 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781002382 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781002383 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781002384 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002385 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002386 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002387 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002388 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002389 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002390 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002391 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002392 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002393 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781002394 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930781002395 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781002396 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002397 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002398 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002399 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781002400 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002401 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781002402 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002403 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781002404 LRR adjacent; Region: LRR_adjacent; pfam08191 930781002405 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002406 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781002407 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781002408 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781002409 beta-galactosidase; Region: BGL; TIGR03356 930781002410 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 930781002411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002412 active site 930781002413 motif I; other site 930781002414 motif II; other site 930781002415 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 930781002416 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 930781002417 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 930781002418 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 930781002419 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 930781002420 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930781002421 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 930781002422 G-loop; other site 930781002423 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930781002424 DNA binding site [nucleotide binding] 930781002425 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 930781002426 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930781002427 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930781002428 Ca binding site [ion binding]; other site 930781002429 active site 930781002430 catalytic site [active] 930781002431 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781002432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002433 dimer interface [polypeptide binding]; other site 930781002434 conserved gate region; other site 930781002435 putative PBP binding loops; other site 930781002436 ABC-ATPase subunit interface; other site 930781002437 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930781002438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002439 dimer interface [polypeptide binding]; other site 930781002440 conserved gate region; other site 930781002441 putative PBP binding loops; other site 930781002442 ABC-ATPase subunit interface; other site 930781002443 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 930781002444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781002445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781002446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781002447 DNA binding site [nucleotide binding] 930781002448 domain linker motif; other site 930781002449 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930781002450 putative dimerization interface [polypeptide binding]; other site 930781002451 putative ligand binding site [chemical binding]; other site 930781002452 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 930781002453 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930781002454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781002455 S-adenosylmethionine binding site [chemical binding]; other site 930781002456 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 930781002457 core dimer interface [polypeptide binding]; other site 930781002458 peripheral dimer interface [polypeptide binding]; other site 930781002459 L10 interface [polypeptide binding]; other site 930781002460 L11 interface [polypeptide binding]; other site 930781002461 putative EF-Tu interaction site [polypeptide binding]; other site 930781002462 putative EF-G interaction site [polypeptide binding]; other site 930781002463 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 930781002464 23S rRNA interface [nucleotide binding]; other site 930781002465 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 930781002466 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 930781002467 mRNA/rRNA interface [nucleotide binding]; other site 930781002468 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 930781002469 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 930781002470 23S rRNA interface [nucleotide binding]; other site 930781002471 L7/L12 interface [polypeptide binding]; other site 930781002472 putative thiostrepton binding site; other site 930781002473 L25 interface [polypeptide binding]; other site 930781002474 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 930781002475 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 930781002476 putative homodimer interface [polypeptide binding]; other site 930781002477 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 930781002478 heterodimer interface [polypeptide binding]; other site 930781002479 homodimer interface [polypeptide binding]; other site 930781002480 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 930781002481 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 930781002482 RNA polymerase factor sigma-70; Validated; Region: PRK08295 930781002483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930781002484 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 930781002485 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 930781002486 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 930781002487 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 930781002488 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930781002489 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930781002490 active site 930781002491 metal binding site [ion binding]; metal-binding site 930781002492 dimerization interface [polypeptide binding]; other site 930781002493 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 930781002494 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930781002495 active site 930781002496 HIGH motif; other site 930781002497 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930781002498 KMSKS motif; other site 930781002499 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 930781002500 tRNA binding surface [nucleotide binding]; other site 930781002501 anticodon binding site; other site 930781002502 serine O-acetyltransferase; Region: cysE; TIGR01172 930781002503 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 930781002504 trimer interface [polypeptide binding]; other site 930781002505 active site 930781002506 substrate binding site [chemical binding]; other site 930781002507 CoA binding site [chemical binding]; other site 930781002508 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 930781002509 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930781002510 HIGH motif; other site 930781002511 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930781002512 active site 930781002513 KMSKS motif; other site 930781002514 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 930781002515 homotrimer interaction site [polypeptide binding]; other site 930781002516 zinc binding site [ion binding]; other site 930781002517 CDP-binding sites; other site 930781002518 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930781002519 substrate binding site; other site 930781002520 dimer interface; other site 930781002521 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 930781002522 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 930781002523 putative active site [active] 930781002524 DNA repair protein RadA; Provisional; Region: PRK11823 930781002525 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 930781002526 Walker A motif/ATP binding site; other site 930781002527 ATP binding site [chemical binding]; other site 930781002528 Walker B motif; other site 930781002529 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 930781002530 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 930781002531 Clp amino terminal domain; Region: Clp_N; pfam02861 930781002532 Clp amino terminal domain; Region: Clp_N; pfam02861 930781002533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781002534 Walker A motif; other site 930781002535 ATP binding site [chemical binding]; other site 930781002536 Walker B motif; other site 930781002537 arginine finger; other site 930781002538 UvrB/uvrC motif; Region: UVR; pfam02151 930781002539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781002540 Walker A motif; other site 930781002541 ATP binding site [chemical binding]; other site 930781002542 Walker B motif; other site 930781002543 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930781002544 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 930781002545 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 930781002546 ADP binding site [chemical binding]; other site 930781002547 phosphagen binding site; other site 930781002548 substrate specificity loop; other site 930781002549 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 930781002550 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 930781002551 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 930781002552 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 930781002553 dimer interface [polypeptide binding]; other site 930781002554 putative anticodon binding site; other site 930781002555 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 930781002556 motif 1; other site 930781002557 active site 930781002558 motif 2; other site 930781002559 motif 3; other site 930781002560 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 930781002561 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 930781002562 FMN binding site [chemical binding]; other site 930781002563 active site 930781002564 catalytic residues [active] 930781002565 substrate binding site [chemical binding]; other site 930781002566 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 930781002567 catalytic center binding site [active] 930781002568 ATP binding site [chemical binding]; other site 930781002569 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 930781002570 homooctamer interface [polypeptide binding]; other site 930781002571 active site 930781002572 dihydropteroate synthase; Region: DHPS; TIGR01496 930781002573 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 930781002574 substrate binding pocket [chemical binding]; other site 930781002575 dimer interface [polypeptide binding]; other site 930781002576 inhibitor binding site; inhibition site 930781002577 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930781002578 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930781002579 dimer interface [polypeptide binding]; other site 930781002580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781002581 catalytic residue [active] 930781002582 pantothenate kinase; Reviewed; Region: PRK13318 930781002583 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 930781002584 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 930781002585 Ligand Binding Site [chemical binding]; other site 930781002586 TilS substrate C-terminal domain; Region: TilS_C; smart00977 930781002587 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930781002588 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781002589 active site 930781002590 hypothetical protein; Provisional; Region: PRK08582 930781002591 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930781002592 RNA binding site [nucleotide binding]; other site 930781002593 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 930781002594 Septum formation initiator; Region: DivIC; pfam04977 930781002595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781002596 RNA binding surface [nucleotide binding]; other site 930781002597 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930781002598 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930781002599 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 930781002600 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 930781002601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781002602 ATP binding site [chemical binding]; other site 930781002603 putative Mg++ binding site [ion binding]; other site 930781002604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781002605 nucleotide binding region [chemical binding]; other site 930781002606 ATP-binding site [chemical binding]; other site 930781002607 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 930781002608 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 930781002609 putative active site [active] 930781002610 catalytic residue [active] 930781002611 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781002612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781002613 Coenzyme A binding pocket [chemical binding]; other site 930781002614 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 930781002615 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 930781002616 5S rRNA interface [nucleotide binding]; other site 930781002617 CTC domain interface [polypeptide binding]; other site 930781002618 L16 interface [polypeptide binding]; other site 930781002619 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 930781002620 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930781002621 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781002622 NAD binding site [chemical binding]; other site 930781002623 dimer interface [polypeptide binding]; other site 930781002624 substrate binding site [chemical binding]; other site 930781002625 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930781002626 A new structural DNA glycosylase; Region: AlkD_like; cd06561 930781002627 active site 930781002628 hypothetical protein; Provisional; Region: PRK01119 930781002629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 930781002630 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 930781002631 Zn binding site [ion binding]; other site 930781002632 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930781002633 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930781002634 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930781002635 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930781002636 active site 930781002637 Zn binding site [ion binding]; other site 930781002638 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 930781002639 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 930781002640 active site 930781002641 catalytic site [active] 930781002642 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781002643 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781002644 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930781002645 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 930781002646 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930781002647 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781002648 active site 930781002649 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 930781002650 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 930781002651 Substrate binding site; other site 930781002652 Mg++ binding site; other site 930781002653 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 930781002654 active site 930781002655 substrate binding site [chemical binding]; other site 930781002656 CoA binding site [chemical binding]; other site 930781002657 regulatory protein SpoVG; Reviewed; Region: PRK13259 930781002658 regulatory protein SpoVG; Reviewed; Region: PRK13259 930781002659 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781002660 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930781002661 FtsX-like permease family; Region: FtsX; pfam02687 930781002662 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781002663 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781002664 Walker A/P-loop; other site 930781002665 ATP binding site [chemical binding]; other site 930781002666 Q-loop/lid; other site 930781002667 ABC transporter signature motif; other site 930781002668 Walker B; other site 930781002669 D-loop; other site 930781002670 H-loop/switch region; other site 930781002671 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930781002672 HlyD family secretion protein; Region: HlyD_3; pfam13437 930781002673 pur operon repressor; Provisional; Region: PRK09213 930781002674 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 930781002675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781002676 active site 930781002677 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 930781002678 putative active site [active] 930781002679 YdjC motif; other site 930781002680 Mg binding site [ion binding]; other site 930781002681 putative homodimer interface [polypeptide binding]; other site 930781002682 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 930781002683 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930781002684 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 930781002685 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 930781002686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781002687 S-adenosylmethionine binding site [chemical binding]; other site 930781002688 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 930781002689 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 930781002690 putative active site [active] 930781002691 putative metal binding site [ion binding]; other site 930781002692 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 930781002693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 930781002694 Domain of unknown function (DUF348); Region: DUF348; pfam03990 930781002695 Domain of unknown function (DUF348); Region: DUF348; pfam03990 930781002696 G5 domain; Region: G5; pfam07501 930781002697 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930781002698 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 930781002699 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930781002700 active site 930781002701 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930781002702 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930781002703 Ca binding site [ion binding]; other site 930781002704 active site 930781002705 catalytic site [active] 930781002706 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 930781002707 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930781002708 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930781002709 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 930781002710 trimer interface [polypeptide binding]; other site 930781002711 active site 930781002712 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 930781002713 catalytic site [active] 930781002714 alpha-glucosidase; Provisional; Region: PRK10426 930781002715 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930781002716 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 930781002717 active site 930781002718 catalytic site [active] 930781002719 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930781002720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781002721 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781002722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002723 dimer interface [polypeptide binding]; other site 930781002724 conserved gate region; other site 930781002725 putative PBP binding loops; other site 930781002726 ABC-ATPase subunit interface; other site 930781002727 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930781002728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002729 dimer interface [polypeptide binding]; other site 930781002730 conserved gate region; other site 930781002731 putative PBP binding loops; other site 930781002732 ABC-ATPase subunit interface; other site 930781002733 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930781002734 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781002735 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781002736 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930781002737 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 930781002738 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 930781002739 active site 930781002740 HIGH motif; other site 930781002741 KMSKS motif; other site 930781002742 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 930781002743 tRNA binding surface [nucleotide binding]; other site 930781002744 anticodon binding site; other site 930781002745 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 930781002746 dimer interface [polypeptide binding]; other site 930781002747 putative tRNA-binding site [nucleotide binding]; other site 930781002748 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930781002749 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781002750 Uncharacterized conserved protein [Function unknown]; Region: COG5361 930781002751 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 930781002752 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 930781002753 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930781002754 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 930781002755 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930781002756 Predicted methyltransferases [General function prediction only]; Region: COG0313 930781002757 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 930781002758 putative SAM binding site [chemical binding]; other site 930781002759 putative homodimer interface [polypeptide binding]; other site 930781002760 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 930781002761 GIY-YIG motif/motif A; other site 930781002762 putative active site [active] 930781002763 putative metal binding site [ion binding]; other site 930781002764 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 930781002765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781002766 S-adenosylmethionine binding site [chemical binding]; other site 930781002767 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 930781002768 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 930781002769 DNA polymerase III subunit delta'; Validated; Region: PRK08058 930781002770 DNA polymerase III subunit delta'; Validated; Region: PRK08485 930781002771 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781002772 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930781002773 Collagen binding domain; Region: Collagen_bind; pfam05737 930781002774 Cna protein B-type domain; Region: Cna_B; pfam05738 930781002775 Cna protein B-type domain; Region: Cna_B; pfam05738 930781002776 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930781002777 Collagen binding domain; Region: Collagen_bind; pfam05737 930781002778 Cna protein B-type domain; Region: Cna_B; pfam05738 930781002779 Cna protein B-type domain; Region: Cna_B; pfam05738 930781002780 Cna protein B-type domain; Region: Cna_B; pfam05738 930781002781 sugar phosphate phosphatase; Provisional; Region: PRK10513 930781002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002783 active site 930781002784 motif I; other site 930781002785 motif II; other site 930781002786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781002787 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 930781002788 DEAD_2; Region: DEAD_2; pfam06733 930781002789 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930781002790 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930781002791 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781002792 ligand binding site [chemical binding]; other site 930781002793 flexible hinge region; other site 930781002794 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930781002795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781002796 ABC-ATPase subunit interface; other site 930781002797 dimer interface [polypeptide binding]; other site 930781002798 putative PBP binding regions; other site 930781002799 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 930781002800 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930781002801 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 930781002802 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 930781002803 metal binding site [ion binding]; metal-binding site 930781002804 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930781002805 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930781002806 peptide binding site [polypeptide binding]; other site 930781002807 phosphoenolpyruvate synthase; Validated; Region: PRK06464 930781002808 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 930781002809 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 930781002810 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930781002811 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930781002812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002813 dimer interface [polypeptide binding]; other site 930781002814 conserved gate region; other site 930781002815 putative PBP binding loops; other site 930781002816 ABC-ATPase subunit interface; other site 930781002817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930781002818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781002819 dimer interface [polypeptide binding]; other site 930781002820 conserved gate region; other site 930781002821 putative PBP binding loops; other site 930781002822 ABC-ATPase subunit interface; other site 930781002823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781002824 Coenzyme A binding pocket [chemical binding]; other site 930781002825 Uncharacterized conserved protein [Function unknown]; Region: COG3592 930781002826 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 930781002827 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930781002828 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 930781002829 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930781002830 active site 930781002831 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930781002832 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930781002833 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 930781002834 putative active site [active] 930781002835 putative metal binding site [ion binding]; other site 930781002836 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930781002837 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930781002838 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930781002839 active site 930781002840 metal binding site [ion binding]; metal-binding site 930781002841 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 930781002842 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 930781002843 Phage tail protein; Region: Sipho_tail; pfam05709 930781002844 Phage-related protein [Function unknown]; Region: COG5412 930781002845 Predicted secreted protein [Function unknown]; Region: COG5437 930781002846 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930781002847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781002848 non-specific DNA binding site [nucleotide binding]; other site 930781002849 salt bridge; other site 930781002850 sequence-specific DNA binding site [nucleotide binding]; other site 930781002851 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930781002852 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781002853 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930781002854 ligand binding site [chemical binding]; other site 930781002855 flexible hinge region; other site 930781002856 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930781002857 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930781002858 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930781002859 substrate binding pocket [chemical binding]; other site 930781002860 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930781002861 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 930781002862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781002863 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781002864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781002865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781002866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781002867 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930781002868 Walker A/P-loop; other site 930781002869 ATP binding site [chemical binding]; other site 930781002870 Q-loop/lid; other site 930781002871 ABC transporter signature motif; other site 930781002872 Walker B; other site 930781002873 D-loop; other site 930781002874 H-loop/switch region; other site 930781002875 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781002876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781002877 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930781002878 Walker A/P-loop; other site 930781002879 ATP binding site [chemical binding]; other site 930781002880 Q-loop/lid; other site 930781002881 ABC transporter signature motif; other site 930781002882 Walker B; other site 930781002883 D-loop; other site 930781002884 H-loop/switch region; other site 930781002885 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781002886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781002887 nucleotide binding site [chemical binding]; other site 930781002888 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 930781002889 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 930781002890 active site 930781002891 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 930781002892 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930781002893 Interdomain contacts; other site 930781002894 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930781002895 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930781002896 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 930781002897 dimer interface [polypeptide binding]; other site 930781002898 FMN binding site [chemical binding]; other site 930781002899 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930781002900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781002901 dimerization interface [polypeptide binding]; other site 930781002902 putative DNA binding site [nucleotide binding]; other site 930781002903 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 930781002904 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 930781002905 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 930781002906 Domain of unknown function (DUF956); Region: DUF956; pfam06115 930781002907 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 930781002908 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 930781002909 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 930781002910 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781002911 active pocket/dimerization site; other site 930781002912 active site 930781002913 phosphorylation site [posttranslational modification] 930781002914 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930781002915 active site 930781002916 phosphorylation site [posttranslational modification] 930781002917 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781002918 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930781002919 gamma subunit interface [polypeptide binding]; other site 930781002920 epsilon subunit interface [polypeptide binding]; other site 930781002921 LBP interface [polypeptide binding]; other site 930781002922 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 930781002923 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930781002924 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930781002925 alpha subunit interaction interface [polypeptide binding]; other site 930781002926 Walker A motif; other site 930781002927 ATP binding site [chemical binding]; other site 930781002928 Walker B motif; other site 930781002929 inhibitor binding site; inhibition site 930781002930 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930781002931 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930781002932 core domain interface [polypeptide binding]; other site 930781002933 delta subunit interface [polypeptide binding]; other site 930781002934 epsilon subunit interface [polypeptide binding]; other site 930781002935 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 930781002936 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930781002937 Walker A motif; other site 930781002938 ATP binding site [chemical binding]; other site 930781002939 Walker B motif; other site 930781002940 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930781002941 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 930781002942 ATP synthase subunit C; Region: ATP-synt_C; cl00466 930781002943 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781002944 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781002945 active site 930781002946 catalytic tetrad [active] 930781002947 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781002948 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781002949 DNA binding residues [nucleotide binding] 930781002950 putative dimer interface [polypeptide binding]; other site 930781002951 LXG domain of WXG superfamily; Region: LXG; pfam04740 930781002952 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 930781002953 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 930781002954 putative ligand binding site [chemical binding]; other site 930781002955 putative NAD binding site [chemical binding]; other site 930781002956 catalytic site [active] 930781002957 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930781002958 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 930781002959 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930781002960 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930781002961 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930781002962 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930781002963 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930781002964 DNA binding site [nucleotide binding] 930781002965 active site 930781002966 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 930781002967 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930781002968 tetramer interface [polypeptide binding]; other site 930781002969 active site 930781002970 Mg2+/Mn2+ binding site [ion binding]; other site 930781002971 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 930781002972 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 930781002973 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 930781002974 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930781002975 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930781002976 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 930781002977 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 930781002978 Uncharacterized small protein [Function unknown]; Region: COG5417 930781002979 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 930781002980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 930781002981 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 930781002982 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 930781002983 GDP-binding site [chemical binding]; other site 930781002984 ACT binding site; other site 930781002985 IMP binding site; other site 930781002986 replicative DNA helicase; Provisional; Region: PRK05748 930781002987 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 930781002988 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 930781002989 Walker A motif; other site 930781002990 ATP binding site [chemical binding]; other site 930781002991 Walker B motif; other site 930781002992 DNA binding loops [nucleotide binding] 930781002993 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 930781002994 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 930781002995 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 930781002996 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 930781002997 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 930781002998 DHH family; Region: DHH; pfam01368 930781002999 DHHA1 domain; Region: DHHA1; pfam02272 930781003000 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930781003001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781003002 active site 930781003003 phosphorylation site [posttranslational modification] 930781003004 intermolecular recognition site; other site 930781003005 LytTr DNA-binding domain; Region: LytTR; pfam04397 930781003006 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 930781003007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781003008 ATP binding site [chemical binding]; other site 930781003009 Mg2+ binding site [ion binding]; other site 930781003010 G-X-G motif; other site 930781003011 Staphylococcal AgrD protein; Region: AgrD; cl05477 930781003012 putative accessory gene regulator protein; Provisional; Region: PRK01100 930781003013 Predicted membrane protein [Function unknown]; Region: COG3212 930781003014 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930781003015 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930781003016 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 930781003017 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930781003018 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930781003019 dimer interface [polypeptide binding]; other site 930781003020 ssDNA binding site [nucleotide binding]; other site 930781003021 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781003022 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 930781003023 arginine deiminase; Provisional; Region: PRK01388 930781003024 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 930781003025 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930781003026 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781003027 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781003028 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003029 putative active site [active] 930781003030 carbamate kinase; Reviewed; Region: PRK12686 930781003031 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 930781003032 putative substrate binding site [chemical binding]; other site 930781003033 nucleotide binding site [chemical binding]; other site 930781003034 nucleotide binding site [chemical binding]; other site 930781003035 homodimer interface [polypeptide binding]; other site 930781003036 agmatine deiminase; Provisional; Region: PRK13551 930781003037 agmatine deiminase; Region: agmatine_aguA; TIGR03380 930781003038 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930781003039 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 930781003040 putrescine carbamoyltransferase; Provisional; Region: PRK02255 930781003041 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930781003042 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930781003043 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930781003044 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930781003045 dimer interface [polypeptide binding]; other site 930781003046 active site 930781003047 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930781003048 dimer interface [polypeptide binding]; other site 930781003049 active site 930781003050 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781003051 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781003052 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 930781003053 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781003054 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781003055 nucleotide binding site [chemical binding]; other site 930781003056 Butyrate kinase [Energy production and conversion]; Region: COG3426 930781003057 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781003058 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781003059 DNA binding site [nucleotide binding] 930781003060 domain linker motif; other site 930781003061 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 930781003062 dimerization interface [polypeptide binding]; other site 930781003063 putative ligand binding site [chemical binding]; other site 930781003064 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781003065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003066 active site 930781003067 motif I; other site 930781003068 motif II; other site 930781003069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003070 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 930781003071 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 930781003072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003073 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 930781003074 Walker A/P-loop; other site 930781003075 ATP binding site [chemical binding]; other site 930781003076 Q-loop/lid; other site 930781003077 ABC transporter signature motif; other site 930781003078 Walker B; other site 930781003079 D-loop; other site 930781003080 H-loop/switch region; other site 930781003081 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930781003082 putative dimer interface [polypeptide binding]; other site 930781003083 catalytic triad [active] 930781003084 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 930781003085 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930781003086 active site turn [active] 930781003087 phosphorylation site [posttranslational modification] 930781003088 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930781003089 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930781003090 HPr interaction site; other site 930781003091 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930781003092 active site 930781003093 phosphorylation site [posttranslational modification] 930781003094 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 930781003095 hypothetical protein; Provisional; Region: PRK02947 930781003096 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003097 putative active site [active] 930781003098 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 930781003099 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 930781003100 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930781003101 active site 930781003102 phosphorylation site [posttranslational modification] 930781003103 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781003104 active site 930781003105 active pocket/dimerization site; other site 930781003106 phosphorylation site [posttranslational modification] 930781003107 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781003108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781003109 DNA-binding site [nucleotide binding]; DNA binding site 930781003110 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930781003111 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 930781003112 Bacterial SH3 domain; Region: SH3_3; pfam08239 930781003113 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930781003114 putative active site [active] 930781003115 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930781003116 beta-galactosidase; Region: BGL; TIGR03356 930781003117 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930781003118 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 930781003119 putative active site [active] 930781003120 putative metal binding site [ion binding]; other site 930781003121 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 930781003122 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 930781003123 Subunit I/III interface [polypeptide binding]; other site 930781003124 Subunit III/IV interface [polypeptide binding]; other site 930781003125 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930781003126 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930781003127 D-pathway; other site 930781003128 Putative ubiquinol binding site [chemical binding]; other site 930781003129 Low-spin heme (heme b) binding site [chemical binding]; other site 930781003130 Putative water exit pathway; other site 930781003131 Binuclear center (heme o3/CuB) [ion binding]; other site 930781003132 K-pathway; other site 930781003133 Putative proton exit pathway; other site 930781003134 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 930781003135 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 930781003136 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 930781003137 SH3-like domain; Region: SH3_8; pfam13457 930781003138 SH3-like domain; Region: SH3_8; pfam13457 930781003139 SH3-like domain; Region: SH3_8; pfam13457 930781003140 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 930781003141 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930781003142 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 930781003143 diphosphomevalonate decarboxylase; Region: PLN02407 930781003144 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 930781003145 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930781003146 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930781003147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930781003148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781003149 Coenzyme A binding pocket [chemical binding]; other site 930781003150 cardiolipin synthetase; Reviewed; Region: PRK12452 930781003151 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930781003152 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930781003153 putative active site [active] 930781003154 catalytic site [active] 930781003155 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930781003156 putative active site [active] 930781003157 catalytic site [active] 930781003158 DNA gyrase subunit A; Validated; Region: PRK05560 930781003159 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930781003160 CAP-like domain; other site 930781003161 active site 930781003162 primary dimer interface [polypeptide binding]; other site 930781003163 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781003164 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781003165 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781003166 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781003167 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781003168 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 930781003169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781003170 Mg2+ binding site [ion binding]; other site 930781003171 G-X-G motif; other site 930781003172 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930781003173 anchoring element; other site 930781003174 dimer interface [polypeptide binding]; other site 930781003175 ATP binding site [chemical binding]; other site 930781003176 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930781003177 active site 930781003178 putative metal-binding site [ion binding]; other site 930781003179 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930781003180 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 930781003181 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 930781003182 Walker A/P-loop; other site 930781003183 ATP binding site [chemical binding]; other site 930781003184 Q-loop/lid; other site 930781003185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003186 ABC transporter signature motif; other site 930781003187 Walker B; other site 930781003188 D-loop; other site 930781003189 H-loop/switch region; other site 930781003190 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 930781003191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930781003192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 930781003193 DNA polymerase III subunit beta; Validated; Region: PRK05643 930781003194 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930781003195 putative DNA binding surface [nucleotide binding]; other site 930781003196 dimer interface [polypeptide binding]; other site 930781003197 beta-clamp/clamp loader binding surface; other site 930781003198 beta-clamp/translesion DNA polymerase binding surface; other site 930781003199 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 930781003200 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930781003201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781003202 Walker A motif; other site 930781003203 ATP binding site [chemical binding]; other site 930781003204 Walker B motif; other site 930781003205 arginine finger; other site 930781003206 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 930781003207 DnaA box-binding interface [nucleotide binding]; other site 930781003208 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 930781003209 ribonuclease P; Reviewed; Region: rnpA; PRK00499 930781003210 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 930781003211 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 930781003212 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 930781003213 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 930781003214 G-X-X-G motif; other site 930781003215 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 930781003216 RxxxH motif; other site 930781003217 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 930781003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003219 putative substrate translocation pore; other site 930781003220 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781003221 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 930781003222 N- and C-terminal domain interface [polypeptide binding]; other site 930781003223 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 930781003224 active site 930781003225 putative catalytic site [active] 930781003226 metal binding site [ion binding]; metal-binding site 930781003227 ATP binding site [chemical binding]; other site 930781003228 carbohydrate binding site [chemical binding]; other site 930781003229 L-rhamnose isomerase; Provisional; Region: PRK01076 930781003230 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 930781003231 intersubunit interface [polypeptide binding]; other site 930781003232 active site 930781003233 Zn2+ binding site [ion binding]; other site 930781003234 Domain of unknown function (DUF718); Region: DUF718; cl01281 930781003235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003236 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781003237 putative substrate translocation pore; other site 930781003238 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003239 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930781003240 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781003241 Coenzyme A binding pocket [chemical binding]; other site 930781003242 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 930781003243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781003244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781003245 DNA binding site [nucleotide binding] 930781003246 domain linker motif; other site 930781003247 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 930781003248 putative dimerization interface [polypeptide binding]; other site 930781003249 putative ligand binding site [chemical binding]; other site 930781003250 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 930781003251 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 930781003252 active site 930781003253 homodimer interface [polypeptide binding]; other site 930781003254 catalytic site [active] 930781003255 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930781003256 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781003257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781003258 dimer interface [polypeptide binding]; other site 930781003259 conserved gate region; other site 930781003260 putative PBP binding loops; other site 930781003261 ABC-ATPase subunit interface; other site 930781003262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781003263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781003264 dimer interface [polypeptide binding]; other site 930781003265 conserved gate region; other site 930781003266 putative PBP binding loops; other site 930781003267 ABC-ATPase subunit interface; other site 930781003268 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930781003269 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 930781003270 putative NAD(P) binding site [chemical binding]; other site 930781003271 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930781003272 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781003273 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781003274 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930781003275 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930781003276 beta-phosphoglucomutase; Region: bPGM; TIGR01990 930781003277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003278 motif II; other site 930781003279 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781003280 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930781003281 catalytic residues [active] 930781003282 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 930781003283 dimer interface [polypeptide binding]; other site 930781003284 FMN binding site [chemical binding]; other site 930781003285 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930781003286 MarR family; Region: MarR_2; pfam12802 930781003287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781003289 putative substrate translocation pore; other site 930781003290 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 930781003291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781003292 catalytic residue [active] 930781003293 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 930781003294 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930781003295 putative ligand binding site [chemical binding]; other site 930781003296 putative NAD binding site [chemical binding]; other site 930781003297 putative catalytic site [active] 930781003298 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 930781003299 L-serine binding site [chemical binding]; other site 930781003300 ACT domain interface; other site 930781003301 Uncharacterized conserved protein [Function unknown]; Region: COG4198 930781003302 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 930781003303 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781003304 Leucine-rich repeats; other site 930781003305 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781003306 Substrate binding site [chemical binding]; other site 930781003307 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781003308 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003309 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003310 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003311 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003312 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003313 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781003314 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781003315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781003316 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 930781003317 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930781003318 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930781003319 metal binding site [ion binding]; metal-binding site 930781003320 dimer interface [polypeptide binding]; other site 930781003321 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930781003322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 930781003323 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930781003324 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930781003325 metal binding site [ion binding]; metal-binding site 930781003326 dimer interface [polypeptide binding]; other site 930781003327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003328 D-galactonate transporter; Region: 2A0114; TIGR00893 930781003329 putative substrate translocation pore; other site 930781003330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781003331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781003332 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930781003333 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930781003334 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 930781003335 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 930781003336 trmE is a tRNA modification GTPase; Region: trmE; cd04164 930781003337 G1 box; other site 930781003338 GTP/Mg2+ binding site [chemical binding]; other site 930781003339 Switch I region; other site 930781003340 G2 box; other site 930781003341 Switch II region; other site 930781003342 G3 box; other site 930781003343 G4 box; other site 930781003344 G5 box; other site 930781003345 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 930781003346 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 930781003347 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 930781003348 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 930781003349 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930781003350 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930781003351 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 930781003352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781003353 S-adenosylmethionine binding site [chemical binding]; other site 930781003354 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 930781003355 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 930781003356 putative active site cavity [active] 930781003357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781003358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781003359 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930781003360 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 930781003361 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 930781003362 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 930781003363 active site 930781003364 P-loop; other site 930781003365 phosphorylation site [posttranslational modification] 930781003366 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 930781003367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003368 motif II; other site 930781003369 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781003370 active site 930781003371 phosphorylation site [posttranslational modification] 930781003372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781003373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781003374 nucleotide binding site [chemical binding]; other site 930781003375 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781003376 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781003377 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003378 putative active site [active] 930781003379 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 930781003380 ParB-like nuclease domain; Region: ParBc; pfam02195 930781003381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781003382 non-specific DNA binding site [nucleotide binding]; other site 930781003383 salt bridge; other site 930781003384 sequence-specific DNA binding site [nucleotide binding]; other site 930781003385 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930781003386 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930781003387 P-loop; other site 930781003388 Magnesium ion binding site [ion binding]; other site 930781003389 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930781003390 Magnesium ion binding site [ion binding]; other site 930781003391 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930781003392 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 930781003393 ParB-like nuclease domain; Region: ParB; smart00470 930781003394 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 930781003395 salt bridge; other site 930781003396 non-specific DNA binding site [nucleotide binding]; other site 930781003397 sequence-specific DNA binding site [nucleotide binding]; other site 930781003398 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 930781003399 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 930781003400 tetramer interface [polypeptide binding]; other site 930781003401 heme binding pocket [chemical binding]; other site 930781003402 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781003403 HTH domain; Region: HTH_11; pfam08279 930781003404 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781003405 PRD domain; Region: PRD; pfam00874 930781003406 PRD domain; Region: PRD; pfam00874 930781003407 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781003408 active site 930781003409 P-loop; other site 930781003410 phosphorylation site [posttranslational modification] 930781003411 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781003412 active site 930781003413 phosphorylation site [posttranslational modification] 930781003414 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781003415 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 930781003416 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781003417 active site 930781003418 P-loop; other site 930781003419 phosphorylation site [posttranslational modification] 930781003420 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 930781003421 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930781003422 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930781003423 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781003424 methionine cluster; other site 930781003425 active site 930781003426 phosphorylation site [posttranslational modification] 930781003427 metal binding site [ion binding]; metal-binding site 930781003428 GTP-binding protein YchF; Reviewed; Region: PRK09601 930781003429 YchF GTPase; Region: YchF; cd01900 930781003430 G1 box; other site 930781003431 GTP/Mg2+ binding site [chemical binding]; other site 930781003432 Switch I region; other site 930781003433 G2 box; other site 930781003434 Switch II region; other site 930781003435 G3 box; other site 930781003436 G4 box; other site 930781003437 G5 box; other site 930781003438 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 930781003439 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 930781003440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003441 putative substrate translocation pore; other site 930781003442 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 930781003443 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 930781003444 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 930781003445 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781003446 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930781003447 Walker A/P-loop; other site 930781003448 ATP binding site [chemical binding]; other site 930781003449 Q-loop/lid; other site 930781003450 ABC transporter signature motif; other site 930781003451 Walker B; other site 930781003452 D-loop; other site 930781003453 H-loop/switch region; other site 930781003454 transcriptional antiterminator BglG; Provisional; Region: PRK09772 930781003455 CAT RNA binding domain; Region: CAT_RBD; smart01061 930781003456 PRD domain; Region: PRD; pfam00874 930781003457 PRD domain; Region: PRD; pfam00874 930781003458 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 930781003459 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930781003460 active site turn [active] 930781003461 phosphorylation site [posttranslational modification] 930781003462 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930781003463 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930781003464 HPr interaction site; other site 930781003465 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930781003466 active site 930781003467 phosphorylation site [posttranslational modification] 930781003468 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930781003469 beta-galactosidase; Region: BGL; TIGR03356 930781003470 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 930781003471 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 930781003472 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930781003473 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930781003474 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930781003475 Walker A/P-loop; other site 930781003476 ATP binding site [chemical binding]; other site 930781003477 Q-loop/lid; other site 930781003478 ABC transporter signature motif; other site 930781003479 Walker B; other site 930781003480 D-loop; other site 930781003481 H-loop/switch region; other site 930781003482 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930781003483 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930781003484 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 930781003485 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781003486 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781003487 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003488 putative active site [active] 930781003489 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781003490 methionine cluster; other site 930781003491 active site 930781003492 phosphorylation site [posttranslational modification] 930781003493 metal binding site [ion binding]; metal-binding site 930781003494 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930781003495 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781003496 nucleotide binding site [chemical binding]; other site 930781003497 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781003498 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781003499 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781003500 active site 930781003501 P-loop; other site 930781003502 phosphorylation site [posttranslational modification] 930781003503 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930781003504 beta-galactosidase; Region: BGL; TIGR03356 930781003505 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930781003506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781003507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781003508 ABC transporter; Region: ABC_tran_2; pfam12848 930781003509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781003510 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 930781003511 putative ADP-ribose binding site [chemical binding]; other site 930781003512 putative active site [active] 930781003513 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 930781003514 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 930781003515 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 930781003516 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930781003517 active site 930781003518 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 930781003519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781003520 ATP binding site [chemical binding]; other site 930781003521 putative Mg++ binding site [ion binding]; other site 930781003522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781003523 nucleotide binding region [chemical binding]; other site 930781003524 ATP-binding site [chemical binding]; other site 930781003525 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 930781003526 HRDC domain; Region: HRDC; pfam00570 930781003527 DNA topoisomerase III; Provisional; Region: PRK07726 930781003528 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 930781003529 active site 930781003530 putative interdomain interaction site [polypeptide binding]; other site 930781003531 putative metal-binding site [ion binding]; other site 930781003532 putative nucleotide binding site [chemical binding]; other site 930781003533 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930781003534 domain I; other site 930781003535 DNA binding groove [nucleotide binding] 930781003536 phosphate binding site [ion binding]; other site 930781003537 domain II; other site 930781003538 domain III; other site 930781003539 nucleotide binding site [chemical binding]; other site 930781003540 catalytic site [active] 930781003541 domain IV; other site 930781003542 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 930781003543 Predicted acyl esterases [General function prediction only]; Region: COG2936 930781003544 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 930781003545 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930781003546 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930781003547 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 930781003548 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 930781003549 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930781003550 Ligand binding site; other site 930781003551 Putative Catalytic site; other site 930781003552 DXD motif; other site 930781003553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781003554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781003555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003556 Walker A/P-loop; other site 930781003557 ATP binding site [chemical binding]; other site 930781003558 Q-loop/lid; other site 930781003559 ABC transporter signature motif; other site 930781003560 Walker B; other site 930781003561 D-loop; other site 930781003562 H-loop/switch region; other site 930781003563 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781003564 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003566 Walker A/P-loop; other site 930781003567 ATP binding site [chemical binding]; other site 930781003568 Q-loop/lid; other site 930781003569 ABC transporter signature motif; other site 930781003570 Walker B; other site 930781003571 D-loop; other site 930781003572 H-loop/switch region; other site 930781003573 aminodeoxychorismate synthase; Provisional; Region: PRK07508 930781003574 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930781003575 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 930781003576 substrate-cofactor binding pocket; other site 930781003577 homodimer interface [polypeptide binding]; other site 930781003578 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930781003579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781003580 catalytic residue [active] 930781003581 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 930781003582 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930781003583 glutamine binding [chemical binding]; other site 930781003584 catalytic triad [active] 930781003585 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 930781003586 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 930781003587 seryl-tRNA synthetase; Provisional; Region: PRK05431 930781003588 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 930781003589 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 930781003590 dimer interface [polypeptide binding]; other site 930781003591 active site 930781003592 motif 1; other site 930781003593 motif 2; other site 930781003594 motif 3; other site 930781003595 TfoX C-terminal domain; Region: TfoX_C; pfam04994 930781003596 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781003597 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781003598 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003599 Walker A/P-loop; other site 930781003600 ATP binding site [chemical binding]; other site 930781003601 Q-loop/lid; other site 930781003602 ABC transporter signature motif; other site 930781003603 Walker B; other site 930781003604 D-loop; other site 930781003605 H-loop/switch region; other site 930781003606 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781003607 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781003608 ligand binding site [chemical binding]; other site 930781003609 flexible hinge region; other site 930781003610 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930781003611 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930781003612 active site 930781003613 intersubunit interactions; other site 930781003614 catalytic residue [active] 930781003615 Src Homology 3 domain superfamily; Region: SH3; cl17036 930781003616 Variant SH3 domain; Region: SH3_2; pfam07653 930781003617 peptide ligand binding site [polypeptide binding]; other site 930781003618 drug efflux system protein MdtG; Provisional; Region: PRK09874 930781003619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781003620 putative substrate translocation pore; other site 930781003621 Pathogenicity locus; Region: Cdd1; pfam11731 930781003622 NAD-dependent deacetylase; Provisional; Region: PRK00481 930781003623 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 930781003624 NAD+ binding site [chemical binding]; other site 930781003625 substrate binding site [chemical binding]; other site 930781003626 putative Zn binding site [ion binding]; other site 930781003627 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930781003628 Domain of unknown function DUF21; Region: DUF21; pfam01595 930781003629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930781003630 Transporter associated domain; Region: CorC_HlyC; pfam03471 930781003631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781003632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781003633 DNA binding site [nucleotide binding] 930781003634 domain linker motif; other site 930781003635 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930781003636 putative dimerization interface [polypeptide binding]; other site 930781003637 putative ligand binding site [chemical binding]; other site 930781003638 glycerate kinase; Region: TIGR00045 930781003639 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 930781003640 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 930781003641 active site 930781003642 homodimer interface [polypeptide binding]; other site 930781003643 catalytic site [active] 930781003644 alpha-mannosidase; Provisional; Region: PRK09819 930781003645 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930781003646 active site 930781003647 metal binding site [ion binding]; metal-binding site 930781003648 catalytic site [active] 930781003649 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 930781003650 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781003651 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781003652 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003653 putative active site [active] 930781003654 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930781003655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003656 active site 930781003657 motif I; other site 930781003658 motif II; other site 930781003659 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 930781003660 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781003661 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781003662 DNA binding residues [nucleotide binding] 930781003663 putative dimer interface [polypeptide binding]; other site 930781003664 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 930781003665 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930781003666 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781003667 MarR family; Region: MarR; pfam01047 930781003668 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930781003669 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930781003670 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930781003671 dimer interface [polypeptide binding]; other site 930781003672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930781003673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930781003674 Coenzyme A binding pocket [chemical binding]; other site 930781003675 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 930781003676 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930781003677 DNA binding residues [nucleotide binding] 930781003678 drug binding residues [chemical binding]; other site 930781003679 dimer interface [polypeptide binding]; other site 930781003680 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930781003681 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930781003682 active site 930781003683 trimer interface [polypeptide binding]; other site 930781003684 allosteric site; other site 930781003685 active site lid [active] 930781003686 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930781003687 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 930781003688 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 930781003689 active site 930781003690 acyl-activating enzyme (AAE) consensus motif; other site 930781003691 putative CoA binding site [chemical binding]; other site 930781003692 AMP binding site [chemical binding]; other site 930781003693 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930781003694 nucleoside/Zn binding site; other site 930781003695 dimer interface [polypeptide binding]; other site 930781003696 catalytic motif [active] 930781003697 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 930781003698 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930781003699 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930781003700 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 930781003701 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 930781003702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781003703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781003704 Walker A/P-loop; other site 930781003705 ATP binding site [chemical binding]; other site 930781003706 Q-loop/lid; other site 930781003707 ABC transporter signature motif; other site 930781003708 Walker B; other site 930781003709 D-loop; other site 930781003710 H-loop/switch region; other site 930781003711 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 930781003712 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781003713 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 930781003714 Walker A/P-loop; other site 930781003715 ATP binding site [chemical binding]; other site 930781003716 Q-loop/lid; other site 930781003717 ABC transporter signature motif; other site 930781003718 Walker B; other site 930781003719 D-loop; other site 930781003720 H-loop/switch region; other site 930781003721 SH3-like domain; Region: SH3_8; pfam13457 930781003722 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 930781003723 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 930781003724 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 930781003725 N- and C-terminal domain interface [polypeptide binding]; other site 930781003726 active site 930781003727 catalytic site [active] 930781003728 metal binding site [ion binding]; metal-binding site 930781003729 carbohydrate binding site [chemical binding]; other site 930781003730 ATP binding site [chemical binding]; other site 930781003731 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 930781003732 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781003733 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781003734 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 930781003735 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 930781003736 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 930781003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781003738 Walker A motif; other site 930781003739 ATP binding site [chemical binding]; other site 930781003740 Walker B motif; other site 930781003741 arginine finger; other site 930781003742 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 930781003743 hypothetical protein; Validated; Region: PRK00153 930781003744 recombination protein RecR; Reviewed; Region: recR; PRK00076 930781003745 RecR protein; Region: RecR; pfam02132 930781003746 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 930781003747 putative active site [active] 930781003748 putative metal-binding site [ion binding]; other site 930781003749 tetramer interface [polypeptide binding]; other site 930781003750 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 930781003751 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781003752 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781003753 active site 930781003754 catalytic tetrad [active] 930781003755 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 930781003756 nudix motif; other site 930781003757 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781003758 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781003759 active site 930781003760 motif I; other site 930781003761 motif II; other site 930781003762 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930781003763 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781003764 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930781003765 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003766 putative active site [active] 930781003767 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 930781003768 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930781003769 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 930781003770 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 930781003771 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930781003772 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 930781003773 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930781003774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781003775 catalytic residue [active] 930781003776 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 930781003777 thymidylate kinase; Validated; Region: tmk; PRK00698 930781003778 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 930781003779 TMP-binding site; other site 930781003780 ATP-binding site [chemical binding]; other site 930781003781 Protein of unknown function (DUF970); Region: DUF970; pfam06153 930781003782 autolysin; Reviewed; Region: PRK06347 930781003783 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781003784 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781003785 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781003786 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781003787 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781003788 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781003789 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781003790 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 930781003791 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930781003792 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781003793 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930781003794 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930781003795 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930781003796 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930781003797 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930781003798 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781003799 methionine cluster; other site 930781003800 active site 930781003801 phosphorylation site [posttranslational modification] 930781003802 metal binding site [ion binding]; metal-binding site 930781003803 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930781003804 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930781003805 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781003806 active site 930781003807 P-loop; other site 930781003808 phosphorylation site [posttranslational modification] 930781003809 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 930781003810 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 930781003811 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781003812 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 930781003813 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 930781003814 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 930781003815 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 930781003816 Ligand Binding Site [chemical binding]; other site 930781003817 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 930781003818 GAF domain; Region: GAF_3; pfam13492 930781003819 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781003820 dimer interface [polypeptide binding]; other site 930781003821 phosphorylation site [posttranslational modification] 930781003822 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781003823 ATP binding site [chemical binding]; other site 930781003824 Mg2+ binding site [ion binding]; other site 930781003825 G-X-G motif; other site 930781003826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781003827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781003828 active site 930781003829 phosphorylation site [posttranslational modification] 930781003830 intermolecular recognition site; other site 930781003831 dimerization interface [polypeptide binding]; other site 930781003832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781003833 DNA binding site [nucleotide binding] 930781003834 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930781003835 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 930781003836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930781003837 Ligand Binding Site [chemical binding]; other site 930781003838 Helix-turn-helix domain; Region: HTH_18; pfam12833 930781003839 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930781003840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781003841 active site 930781003842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 930781003843 Predicted membrane protein [Function unknown]; Region: COG4905 930781003844 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 930781003845 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781003846 PRD domain; Region: PRD; pfam00874 930781003847 PRD domain; Region: PRD; pfam00874 930781003848 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781003849 active site 930781003850 P-loop; other site 930781003851 phosphorylation site [posttranslational modification] 930781003852 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 930781003853 active site 930781003854 phosphorylation site [posttranslational modification] 930781003855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781003856 active site 930781003857 phosphorylation site [posttranslational modification] 930781003858 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 930781003859 active site 930781003860 P-loop; other site 930781003861 phosphorylation site [posttranslational modification] 930781003862 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930781003863 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930781003864 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930781003865 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 930781003866 putative NAD(P) binding site [chemical binding]; other site 930781003867 catalytic Zn binding site [ion binding]; other site 930781003868 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930781003869 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 930781003870 putative NAD(P) binding site [chemical binding]; other site 930781003871 catalytic Zn binding site [ion binding]; other site 930781003872 structural Zn binding site [ion binding]; other site 930781003873 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930781003874 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930781003875 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930781003876 substrate binding site [chemical binding]; other site 930781003877 hexamer interface [polypeptide binding]; other site 930781003878 metal binding site [ion binding]; metal-binding site 930781003879 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930781003880 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930781003881 TPP-binding site [chemical binding]; other site 930781003882 dimer interface [polypeptide binding]; other site 930781003883 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930781003884 PYR/PP interface [polypeptide binding]; other site 930781003885 dimer interface [polypeptide binding]; other site 930781003886 TPP binding site [chemical binding]; other site 930781003887 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930781003888 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930781003889 substrate binding site [chemical binding]; other site 930781003890 hexamer interface [polypeptide binding]; other site 930781003891 metal binding site [ion binding]; metal-binding site 930781003892 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 930781003893 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003894 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781003895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781003896 Coenzyme A binding pocket [chemical binding]; other site 930781003897 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 930781003898 S17 interaction site [polypeptide binding]; other site 930781003899 S8 interaction site; other site 930781003900 16S rRNA interaction site [nucleotide binding]; other site 930781003901 streptomycin interaction site [chemical binding]; other site 930781003902 23S rRNA interaction site [nucleotide binding]; other site 930781003903 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 930781003904 30S ribosomal protein S7; Validated; Region: PRK05302 930781003905 elongation factor G; Reviewed; Region: PRK00007 930781003906 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 930781003907 G1 box; other site 930781003908 putative GEF interaction site [polypeptide binding]; other site 930781003909 GTP/Mg2+ binding site [chemical binding]; other site 930781003910 Switch I region; other site 930781003911 G2 box; other site 930781003912 G3 box; other site 930781003913 Switch II region; other site 930781003914 G4 box; other site 930781003915 G5 box; other site 930781003916 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 930781003917 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 930781003918 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 930781003919 elongation factor Tu; Reviewed; Region: PRK00049 930781003920 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 930781003921 G1 box; other site 930781003922 GEF interaction site [polypeptide binding]; other site 930781003923 GTP/Mg2+ binding site [chemical binding]; other site 930781003924 Switch I region; other site 930781003925 G2 box; other site 930781003926 G3 box; other site 930781003927 Switch II region; other site 930781003928 G4 box; other site 930781003929 G5 box; other site 930781003930 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 930781003931 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 930781003932 Antibiotic Binding Site [chemical binding]; other site 930781003933 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781003934 active site 930781003935 phosphorylation site [posttranslational modification] 930781003936 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 930781003937 active site 930781003938 P-loop; other site 930781003939 phosphorylation site [posttranslational modification] 930781003940 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 930781003941 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 930781003942 active site 930781003943 substrate binding pocket [chemical binding]; other site 930781003944 homodimer interaction site [polypeptide binding]; other site 930781003945 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 930781003946 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 930781003947 hypothetical protein; Provisional; Region: PRK02947 930781003948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781003949 putative active site [active] 930781003950 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 930781003951 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 930781003952 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 930781003953 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930781003954 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930781003955 substrate binding pocket [chemical binding]; other site 930781003956 chain length determination region; other site 930781003957 substrate-Mg2+ binding site; other site 930781003958 catalytic residues [active] 930781003959 aspartate-rich region 1; other site 930781003960 active site lid residues [active] 930781003961 aspartate-rich region 2; other site 930781003962 Predicted membrane protein [Function unknown]; Region: COG4769 930781003963 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 930781003964 trimer interface [polypeptide binding]; other site 930781003965 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930781003966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781003967 Predicted membrane protein [Function unknown]; Region: COG2259 930781003968 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 930781003969 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 930781003970 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 930781003971 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 930781003972 ApbE family; Region: ApbE; pfam02424 930781003973 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 930781003974 UbiA prenyltransferase family; Region: UbiA; pfam01040 930781003975 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930781003976 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 930781003977 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 930781003978 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 930781003979 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 930781003980 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 930781003981 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 930781003982 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 930781003983 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 930781003984 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 930781003985 putative translocon binding site; other site 930781003986 protein-rRNA interface [nucleotide binding]; other site 930781003987 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 930781003988 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 930781003989 G-X-X-G motif; other site 930781003990 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 930781003991 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 930781003992 23S rRNA interface [nucleotide binding]; other site 930781003993 5S rRNA interface [nucleotide binding]; other site 930781003994 putative antibiotic binding site [chemical binding]; other site 930781003995 L25 interface [polypeptide binding]; other site 930781003996 L27 interface [polypeptide binding]; other site 930781003997 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 930781003998 23S rRNA interface [nucleotide binding]; other site 930781003999 putative translocon interaction site; other site 930781004000 signal recognition particle (SRP54) interaction site; other site 930781004001 L23 interface [polypeptide binding]; other site 930781004002 trigger factor interaction site; other site 930781004003 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 930781004004 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 930781004005 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 930781004006 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 930781004007 RNA binding site [nucleotide binding]; other site 930781004008 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 930781004009 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 930781004010 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 930781004011 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 930781004012 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 930781004013 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 930781004014 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930781004015 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930781004016 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 930781004017 5S rRNA interface [nucleotide binding]; other site 930781004018 L27 interface [polypeptide binding]; other site 930781004019 23S rRNA interface [nucleotide binding]; other site 930781004020 L5 interface [polypeptide binding]; other site 930781004021 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 930781004022 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 930781004023 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 930781004024 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 930781004025 23S rRNA binding site [nucleotide binding]; other site 930781004026 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 930781004027 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 930781004028 SecY translocase; Region: SecY; pfam00344 930781004029 adenylate kinase; Reviewed; Region: adk; PRK00279 930781004030 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930781004031 AMP-binding site [chemical binding]; other site 930781004032 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930781004033 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 930781004034 rRNA binding site [nucleotide binding]; other site 930781004035 predicted 30S ribosome binding site; other site 930781004036 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 930781004037 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 930781004038 30S ribosomal protein S13; Region: bact_S13; TIGR03631 930781004039 30S ribosomal protein S11; Validated; Region: PRK05309 930781004040 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 930781004041 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 930781004042 alphaNTD - beta interaction site [polypeptide binding]; other site 930781004043 alphaNTD homodimer interface [polypeptide binding]; other site 930781004044 alphaNTD - beta' interaction site [polypeptide binding]; other site 930781004045 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 930781004046 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 930781004047 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930781004048 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 930781004049 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 930781004050 MgtC family; Region: MgtC; pfam02308 930781004051 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 930781004052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930781004053 Walker A/P-loop; other site 930781004054 ATP binding site [chemical binding]; other site 930781004055 Q-loop/lid; other site 930781004056 ABC transporter signature motif; other site 930781004057 Walker B; other site 930781004058 D-loop; other site 930781004059 H-loop/switch region; other site 930781004060 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 930781004061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930781004062 Walker A/P-loop; other site 930781004063 ATP binding site [chemical binding]; other site 930781004064 Q-loop/lid; other site 930781004065 ABC transporter signature motif; other site 930781004066 Walker B; other site 930781004067 D-loop; other site 930781004068 H-loop/switch region; other site 930781004069 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930781004070 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 930781004071 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 930781004072 dimerization interface 3.5A [polypeptide binding]; other site 930781004073 active site 930781004074 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 930781004075 23S rRNA interface [nucleotide binding]; other site 930781004076 L3 interface [polypeptide binding]; other site 930781004077 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 930781004078 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930781004079 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 930781004080 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930781004081 Int/Topo IB signature motif; other site 930781004082 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930781004083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 930781004084 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 930781004085 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 930781004086 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 930781004087 HNH endonuclease; Region: HNH_2; pfam13391 930781004088 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781004089 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781004090 DNA binding residues [nucleotide binding] 930781004091 putative dimer interface [polypeptide binding]; other site 930781004092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781004093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781004094 active site 930781004095 catalytic tetrad [active] 930781004096 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781004097 SH3-like domain; Region: SH3_8; pfam13457 930781004098 SH3-like domain; Region: SH3_8; pfam13457 930781004099 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 930781004100 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 930781004101 Walker A motif; other site 930781004102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781004103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781004104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781004105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781004106 putative substrate translocation pore; other site 930781004107 Uncharacterized conserved protein [Function unknown]; Region: COG1912 930781004108 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 930781004109 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930781004110 catalytic loop [active] 930781004111 iron binding site [ion binding]; other site 930781004112 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 930781004113 4Fe-4S binding domain; Region: Fer4; pfam00037 930781004114 4Fe-4S binding domain; Region: Fer4; pfam00037 930781004115 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 930781004116 [4Fe-4S] binding site [ion binding]; other site 930781004117 molybdopterin cofactor binding site; other site 930781004118 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 930781004119 molybdopterin cofactor binding site; other site 930781004120 Uncharacterized conserved protein [Function unknown]; Region: COG2427 930781004121 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 930781004122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781004123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781004124 active site 930781004125 phosphorylation site [posttranslational modification] 930781004126 intermolecular recognition site; other site 930781004127 dimerization interface [polypeptide binding]; other site 930781004128 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781004129 DNA binding site [nucleotide binding] 930781004130 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930781004131 dimerization interface [polypeptide binding]; other site 930781004132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781004133 dimer interface [polypeptide binding]; other site 930781004134 phosphorylation site [posttranslational modification] 930781004135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781004136 ATP binding site [chemical binding]; other site 930781004137 Mg2+ binding site [ion binding]; other site 930781004138 G-X-G motif; other site 930781004139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781004140 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930781004141 FtsX-like permease family; Region: FtsX; pfam02687 930781004142 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781004143 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781004144 Walker A/P-loop; other site 930781004145 ATP binding site [chemical binding]; other site 930781004146 Q-loop/lid; other site 930781004147 ABC transporter signature motif; other site 930781004148 Walker B; other site 930781004149 D-loop; other site 930781004150 H-loop/switch region; other site 930781004151 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930781004152 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 930781004153 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781004154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781004155 active site 930781004156 motif I; other site 930781004157 motif II; other site 930781004158 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 930781004159 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930781004160 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 930781004161 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 930781004162 putative NAD(P) binding site [chemical binding]; other site 930781004163 dimer interface [polypeptide binding]; other site 930781004164 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 930781004165 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930781004166 folate binding site [chemical binding]; other site 930781004167 NADP+ binding site [chemical binding]; other site 930781004168 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 930781004169 catalytic triad [active] 930781004170 metal binding site [ion binding]; metal-binding site 930781004171 conserved cis-peptide bond; other site 930781004172 Predicted integral membrane protein [Function unknown]; Region: COG5658 930781004173 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930781004174 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930781004175 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930781004176 peptide binding site [polypeptide binding]; other site 930781004177 conserved hypothetical protein TIGR01655; Region: yxeA_fam 930781004178 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930781004179 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 930781004180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781004181 Zn2+ binding site [ion binding]; other site 930781004182 Mg2+ binding site [ion binding]; other site 930781004183 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 930781004184 active site 1 [active] 930781004185 dimer interface [polypeptide binding]; other site 930781004186 hexamer interface [polypeptide binding]; other site 930781004187 active site 2 [active] 930781004188 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 930781004189 Peptidase family M50; Region: Peptidase_M50; pfam02163 930781004190 active site 930781004191 putative substrate binding region [chemical binding]; other site 930781004192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 930781004193 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 930781004194 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 930781004195 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 930781004196 active site 930781004197 HIGH motif; other site 930781004198 KMSK motif region; other site 930781004199 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 930781004200 tRNA binding surface [nucleotide binding]; other site 930781004201 anticodon binding site; other site 930781004202 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 930781004203 CTP synthetase; Validated; Region: pyrG; PRK05380 930781004204 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 930781004205 Catalytic site [active] 930781004206 active site 930781004207 UTP binding site [chemical binding]; other site 930781004208 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 930781004209 active site 930781004210 putative oxyanion hole; other site 930781004211 catalytic triad [active] 930781004212 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 930781004213 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930781004214 substrate binding site [chemical binding]; other site 930781004215 SH3-like domain; Region: SH3_8; pfam13457 930781004216 SH3-like domain; Region: SH3_8; pfam13457 930781004217 SH3-like domain; Region: SH3_8; pfam13457 930781004218 putative lipid kinase; Reviewed; Region: PRK13055 930781004219 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930781004220 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 930781004221 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930781004222 intersubunit interface [polypeptide binding]; other site 930781004223 active site 930781004224 zinc binding site [ion binding]; other site 930781004225 Na+ binding site [ion binding]; other site 930781004226 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930781004227 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 930781004228 putative ADP-binding pocket [chemical binding]; other site 930781004229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930781004230 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930781004231 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930781004232 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930781004233 hinge; other site 930781004234 active site 930781004235 transcription termination factor Rho; Provisional; Region: rho; PRK09376 930781004236 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 930781004237 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930781004238 RNA binding site [nucleotide binding]; other site 930781004239 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 930781004240 multimer interface [polypeptide binding]; other site 930781004241 Walker A motif; other site 930781004242 ATP binding site [chemical binding]; other site 930781004243 Walker B motif; other site 930781004244 Predicted membrane protein [Function unknown]; Region: COG2246 930781004245 GtrA-like protein; Region: GtrA; pfam04138 930781004246 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 930781004247 homoserine dehydrogenase; Provisional; Region: PRK06349 930781004248 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 930781004249 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930781004250 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 930781004251 threonine synthase; Reviewed; Region: PRK06721 930781004252 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 930781004253 homodimer interface [polypeptide binding]; other site 930781004254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781004255 catalytic residue [active] 930781004256 homoserine kinase; Provisional; Region: PRK01212 930781004257 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930781004258 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930781004259 thymidine kinase; Provisional; Region: PRK04296 930781004260 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930781004261 ATP binding site [chemical binding]; other site 930781004262 Walker A motif; other site 930781004263 Walker B motif; other site 930781004264 peptide chain release factor 1; Validated; Region: prfA; PRK00591 930781004265 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930781004266 RF-1 domain; Region: RF-1; pfam00472 930781004267 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 930781004268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781004269 S-adenosylmethionine binding site [chemical binding]; other site 930781004270 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 930781004271 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 930781004272 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930781004273 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930781004274 active site 930781004275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781004276 active site 930781004277 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 930781004278 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 930781004279 active site 930781004280 homodimer interface [polypeptide binding]; other site 930781004281 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930781004282 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 930781004283 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 930781004284 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 930781004285 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 930781004286 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 930781004287 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 930781004288 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 930781004289 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 930781004290 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930781004291 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 930781004292 beta subunit interaction interface [polypeptide binding]; other site 930781004293 Walker A motif; other site 930781004294 ATP binding site [chemical binding]; other site 930781004295 Walker B motif; other site 930781004296 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930781004297 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930781004298 core domain interface [polypeptide binding]; other site 930781004299 delta subunit interface [polypeptide binding]; other site 930781004300 epsilon subunit interface [polypeptide binding]; other site 930781004301 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 930781004302 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930781004303 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930781004304 alpha subunit interaction interface [polypeptide binding]; other site 930781004305 Walker A motif; other site 930781004306 ATP binding site [chemical binding]; other site 930781004307 Walker B motif; other site 930781004308 inhibitor binding site; inhibition site 930781004309 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930781004310 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 930781004311 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930781004312 gamma subunit interface [polypeptide binding]; other site 930781004313 epsilon subunit interface [polypeptide binding]; other site 930781004314 LBP interface [polypeptide binding]; other site 930781004315 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 930781004316 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930781004317 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930781004318 hinge; other site 930781004319 active site 930781004320 rod shape-determining protein Mbl; Provisional; Region: PRK13928 930781004321 MreB and similar proteins; Region: MreB_like; cd10225 930781004322 nucleotide binding site [chemical binding]; other site 930781004323 Mg binding site [ion binding]; other site 930781004324 putative protofilament interaction site [polypeptide binding]; other site 930781004325 RodZ interaction site [polypeptide binding]; other site 930781004326 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 930781004327 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930781004328 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930781004329 dimer interface [polypeptide binding]; other site 930781004330 ssDNA binding site [nucleotide binding]; other site 930781004331 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781004332 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781004333 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781004334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930781004335 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 930781004336 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930781004337 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 930781004338 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 930781004339 active site 930781004340 octamer interface [polypeptide binding]; other site 930781004341 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930781004342 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930781004343 Mg++ binding site [ion binding]; other site 930781004344 putative catalytic motif [active] 930781004345 substrate binding site [chemical binding]; other site 930781004346 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930781004347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930781004348 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930781004349 Uncharacterized conserved protein [Function unknown]; Region: COG1739 930781004350 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 930781004351 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 930781004352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930781004353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781004354 active site 930781004355 phosphorylation site [posttranslational modification] 930781004356 intermolecular recognition site; other site 930781004357 dimerization interface [polypeptide binding]; other site 930781004358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930781004359 DNA binding residues [nucleotide binding] 930781004360 dimerization interface [polypeptide binding]; other site 930781004361 EDD domain protein, DegV family; Region: DegV; TIGR00762 930781004362 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930781004363 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 930781004364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781004365 ATP binding site [chemical binding]; other site 930781004366 putative Mg++ binding site [ion binding]; other site 930781004367 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781004368 nucleotide binding region [chemical binding]; other site 930781004369 ATP-binding site [chemical binding]; other site 930781004370 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 930781004371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781004372 active site 930781004373 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 930781004374 30S subunit binding site; other site 930781004375 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 930781004376 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930781004377 nucleotide binding region [chemical binding]; other site 930781004378 helicase superfamily c-terminal domain; Region: HELICc; smart00490 930781004379 ATP-binding site [chemical binding]; other site 930781004380 SEC-C motif; Region: SEC-C; pfam02810 930781004381 peptide chain release factor 2; Validated; Region: prfB; PRK00578 930781004382 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930781004383 RF-1 domain; Region: RF-1; pfam00472 930781004384 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930781004385 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781004386 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781004387 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781004388 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 930781004389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781004390 Walker A/P-loop; other site 930781004391 ATP binding site [chemical binding]; other site 930781004392 Q-loop/lid; other site 930781004393 ABC transporter signature motif; other site 930781004394 Walker B; other site 930781004395 D-loop; other site 930781004396 H-loop/switch region; other site 930781004397 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 930781004398 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 930781004399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930781004400 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930781004401 Peptidase family M23; Region: Peptidase_M23; pfam01551 930781004402 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930781004403 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 930781004404 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930781004405 putative active site [active] 930781004406 catalytic site [active] 930781004407 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930781004408 putative active site [active] 930781004409 catalytic site [active] 930781004410 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930781004411 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930781004412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781004414 active site 930781004415 phosphorylation site [posttranslational modification] 930781004416 intermolecular recognition site; other site 930781004417 dimerization interface [polypeptide binding]; other site 930781004418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781004419 DNA binding site [nucleotide binding] 930781004420 HAMP domain; Region: HAMP; pfam00672 930781004421 dimerization interface [polypeptide binding]; other site 930781004422 PAS domain; Region: PAS; smart00091 930781004423 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930781004424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781004425 dimer interface [polypeptide binding]; other site 930781004426 phosphorylation site [posttranslational modification] 930781004427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781004428 ATP binding site [chemical binding]; other site 930781004429 Mg2+ binding site [ion binding]; other site 930781004430 G-X-G motif; other site 930781004431 PBP superfamily domain; Region: PBP_like_2; cl17296 930781004432 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930781004433 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 930781004434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781004435 dimer interface [polypeptide binding]; other site 930781004436 conserved gate region; other site 930781004437 putative PBP binding loops; other site 930781004438 ABC-ATPase subunit interface; other site 930781004439 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 930781004440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781004441 dimer interface [polypeptide binding]; other site 930781004442 conserved gate region; other site 930781004443 putative PBP binding loops; other site 930781004444 ABC-ATPase subunit interface; other site 930781004445 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 930781004446 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930781004447 Walker A/P-loop; other site 930781004448 ATP binding site [chemical binding]; other site 930781004449 Q-loop/lid; other site 930781004450 ABC transporter signature motif; other site 930781004451 Walker B; other site 930781004452 D-loop; other site 930781004453 H-loop/switch region; other site 930781004454 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 930781004455 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930781004456 Walker A/P-loop; other site 930781004457 ATP binding site [chemical binding]; other site 930781004458 Q-loop/lid; other site 930781004459 ABC transporter signature motif; other site 930781004460 Walker B; other site 930781004461 D-loop; other site 930781004462 H-loop/switch region; other site 930781004463 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 930781004464 PhoU domain; Region: PhoU; pfam01895 930781004465 PhoU domain; Region: PhoU; pfam01895 930781004466 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781004467 dimerization interface [polypeptide binding]; other site 930781004468 putative DNA binding site [nucleotide binding]; other site 930781004469 putative Zn2+ binding site [ion binding]; other site 930781004470 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 930781004471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: CsbA; COG4897 930781004472 excinuclease ABC subunit B; Provisional; Region: PRK05298 930781004473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781004474 ATP binding site [chemical binding]; other site 930781004475 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781004476 nucleotide binding region [chemical binding]; other site 930781004477 ATP-binding site [chemical binding]; other site 930781004478 Ultra-violet resistance protein B; Region: UvrB; pfam12344 930781004479 UvrB/uvrC motif; Region: UVR; pfam02151 930781004480 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 930781004481 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930781004482 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930781004483 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 930781004484 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930781004485 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930781004486 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 930781004487 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930781004488 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930781004489 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 930781004490 Predicted membrane protein [Function unknown]; Region: COG1950 930781004491 HPr kinase/phosphorylase; Provisional; Region: PRK05428 930781004492 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 930781004493 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 930781004494 Hpr binding site; other site 930781004495 active site 930781004496 homohexamer subunit interaction site [polypeptide binding]; other site 930781004497 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 930781004498 pyrophosphatase PpaX; Provisional; Region: PRK13288 930781004499 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781004500 motif II; other site 930781004501 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930781004502 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930781004503 putative trimer interface [polypeptide binding]; other site 930781004504 putative CoA binding site [chemical binding]; other site 930781004505 TPR repeat; Region: TPR_11; pfam13414 930781004506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781004507 binding surface 930781004508 TPR motif; other site 930781004509 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930781004510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781004511 binding surface 930781004512 TPR motif; other site 930781004513 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930781004514 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781004515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781004516 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 930781004517 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 930781004518 NAD binding site [chemical binding]; other site 930781004519 homodimer interface [polypeptide binding]; other site 930781004520 active site 930781004521 substrate binding site [chemical binding]; other site 930781004522 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 930781004523 active site 930781004524 catalytic residues [active] 930781004525 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 930781004526 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930781004527 active site 930781004528 substrate binding site [chemical binding]; other site 930781004529 metal binding site [ion binding]; metal-binding site 930781004530 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 930781004531 AAA domain; Region: AAA_18; pfam13238 930781004532 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 930781004533 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 930781004534 phosphate binding site [ion binding]; other site 930781004535 putative substrate binding pocket [chemical binding]; other site 930781004536 dimer interface [polypeptide binding]; other site 930781004537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 930781004538 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 930781004539 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930781004540 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 930781004541 active site 930781004542 FMN binding site [chemical binding]; other site 930781004543 substrate binding site [chemical binding]; other site 930781004544 homotetramer interface [polypeptide binding]; other site 930781004545 catalytic residue [active] 930781004546 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781004547 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781004548 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781004549 Substrate binding site [chemical binding]; other site 930781004550 Leucine rich repeat; Region: LRR_8; pfam13855 930781004551 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781004552 amino acid transporter; Region: 2A0306; TIGR00909 930781004553 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930781004554 Clp protease; Region: CLP_protease; pfam00574 930781004555 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930781004556 oligomer interface [polypeptide binding]; other site 930781004557 active site residues [active] 930781004558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 930781004559 Chitin binding domain; Region: Chitin_bind_3; pfam03067 930781004560 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930781004561 Interdomain contacts; other site 930781004562 Cytokine receptor motif; other site 930781004563 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 930781004564 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930781004565 Interdomain contacts; other site 930781004566 Cytokine receptor motif; other site 930781004567 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930781004568 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930781004569 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930781004570 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930781004571 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 930781004572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781004573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781004574 MMPL family; Region: MMPL; pfam03176 930781004575 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 930781004576 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 930781004577 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 930781004578 active site 930781004579 dimer interface [polypeptide binding]; other site 930781004580 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 930781004581 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 930781004582 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 930781004583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781004584 DNA binding site [nucleotide binding] 930781004585 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930781004586 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930781004587 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 930781004588 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 930781004589 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930781004590 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 930781004591 Phosphoglycerate kinase; Region: PGK; pfam00162 930781004592 substrate binding site [chemical binding]; other site 930781004593 hinge regions; other site 930781004594 ADP binding site [chemical binding]; other site 930781004595 catalytic site [active] 930781004596 triosephosphate isomerase; Provisional; Region: PRK14567 930781004597 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930781004598 substrate binding site [chemical binding]; other site 930781004599 dimer interface [polypeptide binding]; other site 930781004600 catalytic triad [active] 930781004601 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 930781004602 phosphoglyceromutase; Provisional; Region: PRK05434 930781004603 enolase; Provisional; Region: eno; PRK00077 930781004604 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 930781004605 dimer interface [polypeptide binding]; other site 930781004606 metal binding site [ion binding]; metal-binding site 930781004607 substrate binding pocket [chemical binding]; other site 930781004608 PGAP1-like protein; Region: PGAP1; pfam07819 930781004609 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930781004610 Esterase/lipase [General function prediction only]; Region: COG1647 930781004611 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781004612 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 930781004613 Preprotein translocase SecG subunit; Region: SecG; cl09123 930781004614 Esterase/lipase [General function prediction only]; Region: COG1647 930781004615 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781004616 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930781004617 ribonuclease R; Region: RNase_R; TIGR02063 930781004618 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 930781004619 RNB domain; Region: RNB; pfam00773 930781004620 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 930781004621 RNA binding site [nucleotide binding]; other site 930781004622 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 930781004623 SmpB-tmRNA interface; other site 930781004624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004625 non-specific DNA binding site [nucleotide binding]; other site 930781004626 salt bridge; other site 930781004627 sequence-specific DNA binding site [nucleotide binding]; other site 930781004628 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930781004629 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930781004630 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930781004631 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 930781004632 active site 930781004633 catalytic site [active] 930781004634 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930781004635 putative metal binding site [ion binding]; other site 930781004636 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781004637 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930781004638 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 930781004639 active site 930781004640 catalytic site [active] 930781004641 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930781004642 putative metal binding site [ion binding]; other site 930781004643 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930781004644 putative metal binding site [ion binding]; other site 930781004645 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781004646 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930781004647 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930781004648 putative active site [active] 930781004649 Predicted transcriptional regulator [Transcription]; Region: COG2378 930781004650 HTH domain; Region: HTH_11; pfam08279 930781004651 WYL domain; Region: WYL; pfam13280 930781004652 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930781004653 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 930781004654 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 930781004655 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 930781004656 SdpI/YhfL protein family; Region: SdpI; pfam13630 930781004657 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 930781004658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781004659 catalytic residue [active] 930781004660 Predicted esterase [General function prediction only]; Region: COG0627 930781004661 S-formylglutathione hydrolase; Region: PLN02442 930781004662 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930781004663 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930781004664 intersubunit interface [polypeptide binding]; other site 930781004665 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930781004666 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781004667 ABC-ATPase subunit interface; other site 930781004668 dimer interface [polypeptide binding]; other site 930781004669 putative PBP binding regions; other site 930781004670 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930781004671 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930781004672 Walker A/P-loop; other site 930781004673 ATP binding site [chemical binding]; other site 930781004674 Q-loop/lid; other site 930781004675 ABC transporter signature motif; other site 930781004676 Walker B; other site 930781004677 D-loop; other site 930781004678 H-loop/switch region; other site 930781004679 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930781004680 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930781004681 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 930781004682 ArsC family; Region: ArsC; pfam03960 930781004683 putative ArsC-like catalytic residues; other site 930781004684 putative TRX-like catalytic residues [active] 930781004685 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 930781004686 lipoyl attachment site [posttranslational modification]; other site 930781004687 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781004688 catalytic residues [active] 930781004689 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930781004690 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930781004691 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781004692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781004693 active site 930781004694 phosphorylation site [posttranslational modification] 930781004695 intermolecular recognition site; other site 930781004696 dimerization interface [polypeptide binding]; other site 930781004697 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781004698 DNA binding site [nucleotide binding] 930781004699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781004700 dimer interface [polypeptide binding]; other site 930781004701 phosphorylation site [posttranslational modification] 930781004702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781004703 ATP binding site [chemical binding]; other site 930781004704 Mg2+ binding site [ion binding]; other site 930781004705 G-X-G motif; other site 930781004706 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 930781004707 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930781004708 Walker A/P-loop; other site 930781004709 ATP binding site [chemical binding]; other site 930781004710 Q-loop/lid; other site 930781004711 ABC transporter signature motif; other site 930781004712 Walker B; other site 930781004713 D-loop; other site 930781004714 H-loop/switch region; other site 930781004715 NIL domain; Region: NIL; pfam09383 930781004716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781004717 ABC-ATPase subunit interface; other site 930781004718 putative PBP binding loops; other site 930781004719 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930781004720 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930781004721 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 930781004722 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 930781004723 Walker A/P-loop; other site 930781004724 ATP binding site [chemical binding]; other site 930781004725 Q-loop/lid; other site 930781004726 ABC transporter signature motif; other site 930781004727 Walker B; other site 930781004728 D-loop; other site 930781004729 H-loop/switch region; other site 930781004730 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 930781004731 FeS assembly protein SufD; Region: sufD; TIGR01981 930781004732 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 930781004733 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 930781004734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781004735 catalytic residue [active] 930781004736 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 930781004737 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 930781004738 trimerization site [polypeptide binding]; other site 930781004739 active site 930781004740 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 930781004741 FeS assembly protein SufB; Region: sufB; TIGR01980 930781004742 Uncharacterized conserved protein [Function unknown]; Region: COG1801 930781004743 Predicted membrane protein [Function unknown]; Region: COG4272 930781004744 Predicted permeases [General function prediction only]; Region: COG0730 930781004745 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930781004746 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 930781004747 active site 930781004748 metal binding site [ion binding]; metal-binding site 930781004749 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930781004750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 930781004751 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 930781004752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781004753 active site 930781004754 motif I; other site 930781004755 motif II; other site 930781004756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781004757 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781004758 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781004759 Coenzyme A binding pocket [chemical binding]; other site 930781004760 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930781004761 Domain of unknown function DUF21; Region: DUF21; pfam01595 930781004762 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930781004763 Transporter associated domain; Region: CorC_HlyC; smart01091 930781004764 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 930781004765 tetramer interfaces [polypeptide binding]; other site 930781004766 binuclear metal-binding site [ion binding]; other site 930781004767 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 930781004768 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781004769 Leucine-rich repeats; other site 930781004770 Substrate binding site [chemical binding]; other site 930781004771 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781004772 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781004773 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781004774 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781004775 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781004776 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781004777 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781004778 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781004779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 930781004780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 930781004781 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 930781004782 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930781004783 NAD(P) binding site [chemical binding]; other site 930781004784 putative active site [active] 930781004785 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930781004786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781004787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781004788 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930781004789 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781004790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 930781004791 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781004792 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 930781004793 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 930781004794 Cl- selectivity filter; other site 930781004795 Cl- binding residues [ion binding]; other site 930781004796 pore gating glutamate residue; other site 930781004797 dimer interface [polypeptide binding]; other site 930781004798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 930781004799 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930781004800 CoenzymeA binding site [chemical binding]; other site 930781004801 subunit interaction site [polypeptide binding]; other site 930781004802 PHB binding site; other site 930781004803 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 930781004804 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 930781004805 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 930781004806 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 930781004807 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930781004808 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 930781004809 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 930781004810 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 930781004811 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930781004812 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 930781004813 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 930781004814 active site 930781004815 aspartate kinase; Reviewed; Region: PRK09034 930781004816 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 930781004817 putative catalytic residues [active] 930781004818 putative nucleotide binding site [chemical binding]; other site 930781004819 putative aspartate binding site [chemical binding]; other site 930781004820 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 930781004821 allosteric regulatory residue; other site 930781004822 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 930781004823 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781004824 active site 930781004825 P-loop; other site 930781004826 phosphorylation site [posttranslational modification] 930781004827 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781004828 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781004829 Walker A/P-loop; other site 930781004830 ATP binding site [chemical binding]; other site 930781004831 Q-loop/lid; other site 930781004832 ABC transporter signature motif; other site 930781004833 Walker B; other site 930781004834 D-loop; other site 930781004835 H-loop/switch region; other site 930781004836 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930781004837 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 930781004838 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781004839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781004840 homodimer interface [polypeptide binding]; other site 930781004841 catalytic residue [active] 930781004842 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930781004843 nudix motif; other site 930781004844 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 930781004845 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 930781004846 active site 930781004847 dimer interface [polypeptide binding]; other site 930781004848 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 930781004849 dimer interface [polypeptide binding]; other site 930781004850 active site 930781004851 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781004852 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930781004853 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781004854 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 930781004855 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781004856 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 930781004857 L-tyrosine decarboxylase; Provisional; Region: PRK13520 930781004858 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 930781004859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781004860 catalytic residue [active] 930781004861 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 930781004862 Predicted transcriptional regulator [Transcription]; Region: COG1959 930781004863 Transcriptional regulator; Region: Rrf2; pfam02082 930781004864 Predicted membrane protein [Function unknown]; Region: COG1511 930781004865 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930781004866 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 930781004867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781004868 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781004869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930781004870 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930781004871 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930781004872 active site 930781004873 trimer interface [polypeptide binding]; other site 930781004874 allosteric site; other site 930781004875 active site lid [active] 930781004876 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930781004877 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 930781004878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781004879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781004880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781004881 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 930781004882 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 930781004883 active site 930781004884 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930781004885 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781004886 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781004887 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930781004888 dimerization interface [polypeptide binding]; other site 930781004889 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930781004890 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930781004891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781004892 Coenzyme A binding pocket [chemical binding]; other site 930781004893 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930781004894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930781004895 substrate binding pocket [chemical binding]; other site 930781004896 membrane-bound complex binding site; other site 930781004897 hinge residues; other site 930781004898 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930781004899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781004900 dimer interface [polypeptide binding]; other site 930781004901 conserved gate region; other site 930781004902 putative PBP binding loops; other site 930781004903 ABC-ATPase subunit interface; other site 930781004904 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930781004905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781004906 dimer interface [polypeptide binding]; other site 930781004907 conserved gate region; other site 930781004908 putative PBP binding loops; other site 930781004909 ABC-ATPase subunit interface; other site 930781004910 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930781004911 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930781004912 Walker A/P-loop; other site 930781004913 ATP binding site [chemical binding]; other site 930781004914 Q-loop/lid; other site 930781004915 ABC transporter signature motif; other site 930781004916 Walker B; other site 930781004917 D-loop; other site 930781004918 H-loop/switch region; other site 930781004919 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 930781004920 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930781004921 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930781004922 catalytic residues [active] 930781004923 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 930781004924 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 930781004925 active site 930781004926 non-prolyl cis peptide bond; other site 930781004927 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930781004928 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781004929 RNA binding surface [nucleotide binding]; other site 930781004930 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 930781004931 active site 930781004932 uracil binding [chemical binding]; other site 930781004933 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930781004934 non-specific DNA interactions [nucleotide binding]; other site 930781004935 DNA binding site [nucleotide binding] 930781004936 sequence specific DNA binding site [nucleotide binding]; other site 930781004937 putative cAMP binding site [chemical binding]; other site 930781004938 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 930781004939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930781004940 substrate binding site [chemical binding]; other site 930781004941 ATP binding site [chemical binding]; other site 930781004942 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 930781004943 Uncharacterized conserved protein [Function unknown]; Region: COG1683 930781004944 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781004945 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930781004946 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781004947 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930781004948 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930781004949 putative substrate binding site [chemical binding]; other site 930781004950 putative ATP binding site [chemical binding]; other site 930781004951 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 930781004952 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781004953 active site 930781004954 phosphorylation site [posttranslational modification] 930781004955 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930781004956 active site 930781004957 P-loop; other site 930781004958 phosphorylation site [posttranslational modification] 930781004959 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930781004960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930781004961 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004962 non-specific DNA binding site [nucleotide binding]; other site 930781004963 salt bridge; other site 930781004964 sequence-specific DNA binding site [nucleotide binding]; other site 930781004965 ComK protein; Region: ComK; cl11560 930781004966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 930781004967 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 930781004968 catalytic residues [active] 930781004969 catalytic nucleophile [active] 930781004970 Presynaptic Site I dimer interface [polypeptide binding]; other site 930781004971 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 930781004972 Synaptic Flat tetramer interface [polypeptide binding]; other site 930781004973 Synaptic Site I dimer interface [polypeptide binding]; other site 930781004974 DNA binding site [nucleotide binding] 930781004975 Recombinase; Region: Recombinase; pfam07508 930781004976 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 930781004977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004978 non-specific DNA binding site [nucleotide binding]; other site 930781004979 salt bridge; other site 930781004980 sequence-specific DNA binding site [nucleotide binding]; other site 930781004981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004982 non-specific DNA binding site [nucleotide binding]; other site 930781004983 salt bridge; other site 930781004984 sequence-specific DNA binding site [nucleotide binding]; other site 930781004985 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930781004986 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004987 non-specific DNA binding site [nucleotide binding]; other site 930781004988 salt bridge; other site 930781004989 sequence-specific DNA binding site [nucleotide binding]; other site 930781004990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781004991 non-specific DNA binding site [nucleotide binding]; other site 930781004992 salt bridge; other site 930781004993 sequence-specific DNA binding site [nucleotide binding]; other site 930781004994 AntA/AntB antirepressor; Region: AntA; pfam08346 930781004995 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 930781004996 Helix-turn-helix domain; Region: HTH_17; pfam12728 930781004997 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 930781004998 Phage-related protein, predicted endonuclease [DNA replication, recombination, and repair]; Region: COG5377 930781004999 Recombinational DNA repair protein (RecE pathway) [DNA replication, recombination, and repair]; Region: RecT; COG3723 930781005000 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 930781005001 YopX protein; Region: YopX; pfam09643 930781005002 hypothetical protein; Provisional; Region: PRK10220 930781005003 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930781005004 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930781005005 dimer interface [polypeptide binding]; other site 930781005006 ssDNA binding site [nucleotide binding]; other site 930781005007 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781005008 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 930781005009 Protein of unknown function (DUF2481); Region: DUF2481; pfam10654 930781005010 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 930781005011 positive control sigma-like factor; Validated; Region: PRK06930 930781005012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930781005013 DNA binding residues [nucleotide binding] 930781005014 Uncharacterized conserved protein [Function unknown]; Region: COG5484 930781005015 Phage terminase small subunit; Region: Phage_terminase; pfam10668 930781005016 phage terminase, large subunit, PBSX family; Region: phage_term_2; TIGR01547 930781005017 Terminase-like family; Region: Terminase_6; pfam03237 930781005018 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 930781005019 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 930781005020 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 930781005021 Phage tail protein; Region: Sipho_tail; pfam05709 930781005022 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 930781005023 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 930781005024 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 930781005025 holin, phage phi LC3 family; Region: holin_phiLC3; TIGR01598 930781005026 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 930781005027 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930781005028 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 930781005029 ComK protein; Region: ComK; cl11560 930781005030 IDEAL domain; Region: IDEAL; pfam08858 930781005031 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 930781005032 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930781005033 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 930781005034 Part of AAA domain; Region: AAA_19; pfam13245 930781005035 Family description; Region: UvrD_C_2; pfam13538 930781005036 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930781005037 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930781005038 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930781005039 hypothetical protein; Provisional; Region: PRK13673 930781005040 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930781005041 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781005042 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781005043 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781005044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930781005045 motif II; other site 930781005046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781005047 esterase; Provisional; Region: PRK10566 930781005048 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930781005049 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 930781005050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781005051 Coenzyme A binding pocket [chemical binding]; other site 930781005052 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781005053 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781005054 methionine cluster; other site 930781005055 active site 930781005056 phosphorylation site [posttranslational modification] 930781005057 metal binding site [ion binding]; metal-binding site 930781005058 intracellular protease, PfpI family; Region: PfpI; TIGR01382 930781005059 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 930781005060 proposed catalytic triad [active] 930781005061 conserved cys residue [active] 930781005062 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930781005063 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 930781005064 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781005065 motif II; other site 930781005066 aspartate aminotransferase; Provisional; Region: PRK06348 930781005067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781005068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781005069 homodimer interface [polypeptide binding]; other site 930781005070 catalytic residue [active] 930781005071 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930781005072 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930781005073 Walker A/P-loop; other site 930781005074 ATP binding site [chemical binding]; other site 930781005075 Q-loop/lid; other site 930781005076 ABC transporter signature motif; other site 930781005077 Walker B; other site 930781005078 D-loop; other site 930781005079 H-loop/switch region; other site 930781005080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930781005081 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930781005082 substrate binding pocket [chemical binding]; other site 930781005083 membrane-bound complex binding site; other site 930781005084 hinge residues; other site 930781005085 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930781005086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005087 dimer interface [polypeptide binding]; other site 930781005088 conserved gate region; other site 930781005089 putative PBP binding loops; other site 930781005090 ABC-ATPase subunit interface; other site 930781005091 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930781005092 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 930781005093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781005094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781005095 active site 930781005096 catalytic tetrad [active] 930781005097 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930781005098 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 930781005099 active site 930781005100 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 930781005101 putative dimer interface [polypeptide binding]; other site 930781005102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781005103 ligand binding site [chemical binding]; other site 930781005104 Zn binding site [ion binding]; other site 930781005105 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930781005106 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930781005107 active site 930781005108 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930781005109 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930781005110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781005111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781005112 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930781005113 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930781005114 DNA binding site [nucleotide binding] 930781005115 active site 930781005116 Predicted transcriptional regulators [Transcription]; Region: COG1725 930781005117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781005118 DNA-binding site [nucleotide binding]; DNA binding site 930781005119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781005120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781005121 putative substrate translocation pore; other site 930781005122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781005123 putative substrate translocation pore; other site 930781005124 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781005125 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 930781005126 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930781005127 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930781005128 shikimate binding site; other site 930781005129 NAD(P) binding site [chemical binding]; other site 930781005130 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 930781005131 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 930781005132 active site 930781005133 FMN binding site [chemical binding]; other site 930781005134 substrate binding site [chemical binding]; other site 930781005135 putative catalytic residue [active] 930781005136 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781005137 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781005138 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930781005139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781005140 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781005141 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930781005142 putative dimerization interface [polypeptide binding]; other site 930781005143 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930781005144 Domain of unknown function DUF21; Region: DUF21; pfam01595 930781005145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930781005146 Transporter associated domain; Region: CorC_HlyC; smart01091 930781005147 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930781005148 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930781005149 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930781005150 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930781005151 Transglycosylase; Region: Transgly; pfam00912 930781005152 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930781005153 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930781005154 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930781005155 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781005156 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930781005157 Walker A/P-loop; other site 930781005158 ATP binding site [chemical binding]; other site 930781005159 Q-loop/lid; other site 930781005160 ABC transporter signature motif; other site 930781005161 Walker B; other site 930781005162 D-loop; other site 930781005163 H-loop/switch region; other site 930781005164 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930781005165 fumarate hydratase; Reviewed; Region: fumC; PRK00485 930781005166 Class II fumarases; Region: Fumarase_classII; cd01362 930781005167 active site 930781005168 tetramer interface [polypeptide binding]; other site 930781005169 hypothetical protein; Provisional; Region: PRK13676 930781005170 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930781005171 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930781005172 active site 930781005173 metal binding site [ion binding]; metal-binding site 930781005174 DNA binding site [nucleotide binding] 930781005175 Uncharacterized conserved protein [Function unknown]; Region: COG4717 930781005176 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 930781005177 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 930781005178 generic binding surface II; other site 930781005179 generic binding surface I; other site 930781005180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781005181 Zn2+ binding site [ion binding]; other site 930781005182 Mg2+ binding site [ion binding]; other site 930781005183 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 930781005184 SurA N-terminal domain; Region: SurA_N_3; cl07813 930781005185 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930781005186 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 930781005187 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 930781005188 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 930781005189 HIT family signature motif; other site 930781005190 catalytic residue [active] 930781005191 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930781005192 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930781005193 Walker A/P-loop; other site 930781005194 ATP binding site [chemical binding]; other site 930781005195 Q-loop/lid; other site 930781005196 ABC transporter signature motif; other site 930781005197 Walker B; other site 930781005198 D-loop; other site 930781005199 H-loop/switch region; other site 930781005200 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 930781005201 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 930781005202 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 930781005203 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 930781005204 substrate binding site [chemical binding]; other site 930781005205 active site 930781005206 ferrochelatase; Provisional; Region: PRK12435 930781005207 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 930781005208 C-terminal domain interface [polypeptide binding]; other site 930781005209 active site 930781005210 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 930781005211 active site 930781005212 N-terminal domain interface [polypeptide binding]; other site 930781005213 Predicted acetyltransferase [General function prediction only]; Region: COG3393 930781005214 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930781005215 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930781005216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781005217 active site 930781005218 motif I; other site 930781005219 motif II; other site 930781005220 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930781005221 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 930781005222 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 930781005223 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 930781005224 Clp amino terminal domain; Region: Clp_N; pfam02861 930781005225 Clp amino terminal domain; Region: Clp_N; pfam02861 930781005226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781005227 Walker A motif; other site 930781005228 ATP binding site [chemical binding]; other site 930781005229 Walker B motif; other site 930781005230 arginine finger; other site 930781005231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781005232 Walker A motif; other site 930781005233 ATP binding site [chemical binding]; other site 930781005234 Walker B motif; other site 930781005235 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930781005236 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781005237 catalytic core [active] 930781005238 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781005239 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 930781005240 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781005241 SH3-like domain; Region: SH3_8; pfam13457 930781005242 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 930781005243 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930781005244 dimer interface [polypeptide binding]; other site 930781005245 active site 930781005246 CoA binding pocket [chemical binding]; other site 930781005247 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930781005248 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930781005249 dimer interface [polypeptide binding]; other site 930781005250 active site 930781005251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781005252 MarR family; Region: MarR; pfam01047 930781005253 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 930781005254 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 930781005255 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 930781005256 active site 930781005257 HIGH motif; other site 930781005258 dimer interface [polypeptide binding]; other site 930781005259 KMSKS motif; other site 930781005260 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 930781005261 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930781005262 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930781005263 peptide binding site [polypeptide binding]; other site 930781005264 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930781005265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005266 dimer interface [polypeptide binding]; other site 930781005267 conserved gate region; other site 930781005268 putative PBP binding loops; other site 930781005269 ABC-ATPase subunit interface; other site 930781005270 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930781005271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005272 dimer interface [polypeptide binding]; other site 930781005273 conserved gate region; other site 930781005274 putative PBP binding loops; other site 930781005275 ABC-ATPase subunit interface; other site 930781005276 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930781005277 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930781005278 Walker A/P-loop; other site 930781005279 ATP binding site [chemical binding]; other site 930781005280 Q-loop/lid; other site 930781005281 ABC transporter signature motif; other site 930781005282 Walker B; other site 930781005283 D-loop; other site 930781005284 H-loop/switch region; other site 930781005285 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930781005286 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930781005287 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930781005288 Walker A/P-loop; other site 930781005289 ATP binding site [chemical binding]; other site 930781005290 Q-loop/lid; other site 930781005291 ABC transporter signature motif; other site 930781005292 Walker B; other site 930781005293 D-loop; other site 930781005294 H-loop/switch region; other site 930781005295 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930781005296 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 930781005297 ArsC family; Region: ArsC; pfam03960 930781005298 putative catalytic residues [active] 930781005299 thiol/disulfide switch; other site 930781005300 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 930781005301 Competence protein CoiA-like family; Region: CoiA; cl11541 930781005302 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 930781005303 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 930781005304 active site 930781005305 Zn binding site [ion binding]; other site 930781005306 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930781005307 heme uptake protein IsdC; Region: IsdC; TIGR03656 930781005308 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930781005309 heme-binding site [chemical binding]; other site 930781005310 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 930781005311 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930781005312 heme-binding site [chemical binding]; other site 930781005313 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 930781005314 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930781005315 heme-binding site [chemical binding]; other site 930781005316 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930781005317 heme-binding site [chemical binding]; other site 930781005318 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 930781005319 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 930781005320 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930781005321 intersubunit interface [polypeptide binding]; other site 930781005322 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930781005323 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781005324 ABC-ATPase subunit interface; other site 930781005325 dimer interface [polypeptide binding]; other site 930781005326 putative PBP binding regions; other site 930781005327 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930781005328 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930781005329 Walker A/P-loop; other site 930781005330 ATP binding site [chemical binding]; other site 930781005331 Q-loop/lid; other site 930781005332 ABC transporter signature motif; other site 930781005333 Walker B; other site 930781005334 D-loop; other site 930781005335 H-loop/switch region; other site 930781005336 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 930781005337 active site 930781005338 catalytic site [active] 930781005339 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781005340 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781005341 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781005342 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930781005343 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005344 Collagen binding domain; Region: Collagen_bind; pfam05737 930781005345 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005346 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005347 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005348 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005349 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005350 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005351 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781005352 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781005353 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930781005354 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005355 Collagen binding domain; Region: Collagen_bind; pfam05737 930781005356 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005357 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005358 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005359 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781005360 Tic20-like protein; Region: Tic20; pfam09685 930781005361 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930781005362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781005363 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930781005364 classical (c) SDRs; Region: SDR_c; cd05233 930781005365 NAD(P) binding site [chemical binding]; other site 930781005366 active site 930781005367 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930781005368 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930781005369 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930781005370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930781005371 metal binding site [ion binding]; metal-binding site 930781005372 active site 930781005373 I-site; other site 930781005374 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781005375 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 930781005376 Walker A motif; other site 930781005377 ATP binding site [chemical binding]; other site 930781005378 Walker B motif; other site 930781005379 arginine finger; other site 930781005380 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930781005381 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 930781005382 Coenzyme A transferase; Region: CoA_trans; smart00882 930781005383 Coenzyme A transferase; Region: CoA_trans; cl17247 930781005384 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 930781005385 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 930781005386 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930781005387 FMN binding site [chemical binding]; other site 930781005388 substrate binding site [chemical binding]; other site 930781005389 putative catalytic residue [active] 930781005390 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781005391 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 930781005392 dimer interface [polypeptide binding]; other site 930781005393 active site 930781005394 metal binding site [ion binding]; metal-binding site 930781005395 glutathione binding site [chemical binding]; other site 930781005396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781005397 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781005398 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781005399 ligand binding site [chemical binding]; other site 930781005400 flexible hinge region; other site 930781005401 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 930781005402 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781005403 Cupin; Region: Cupin_1; pfam00190 930781005404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781005405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781005406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781005407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781005408 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930781005409 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930781005410 conserved cys residue [active] 930781005411 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930781005412 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 930781005413 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781005414 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781005415 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930781005416 CsbD-like; Region: CsbD; cl17424 930781005417 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 930781005418 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930781005419 SCP-2 sterol transfer family; Region: SCP2; cl01225 930781005420 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 930781005421 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 930781005422 Class I ribonucleotide reductase; Region: RNR_I; cd01679 930781005423 active site 930781005424 dimer interface [polypeptide binding]; other site 930781005425 catalytic residues [active] 930781005426 effector binding site; other site 930781005427 R2 peptide binding site; other site 930781005428 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 930781005429 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 930781005430 dimer interface [polypeptide binding]; other site 930781005431 putative radical transfer pathway; other site 930781005432 diiron center [ion binding]; other site 930781005433 tyrosyl radical; other site 930781005434 flavodoxin; Provisional; Region: PRK09271 930781005435 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781005436 catalytic residues [active] 930781005437 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 930781005438 homodimer interface [polypeptide binding]; other site 930781005439 chemical substrate binding site [chemical binding]; other site 930781005440 oligomer interface [polypeptide binding]; other site 930781005441 metal binding site [ion binding]; metal-binding site 930781005442 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 930781005443 putative metal binding site [ion binding]; other site 930781005444 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 930781005445 Predicted membrane protein [Function unknown]; Region: COG2855 930781005446 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781005447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781005448 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 930781005449 putative dimerization interface [polypeptide binding]; other site 930781005450 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 930781005451 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 930781005452 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781005453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781005454 DNA-binding site [nucleotide binding]; DNA binding site 930781005455 UTRA domain; Region: UTRA; pfam07702 930781005456 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 930781005457 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 930781005458 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930781005459 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930781005460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781005461 Coenzyme A binding pocket [chemical binding]; other site 930781005462 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 930781005463 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 930781005464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781005465 Walker A/P-loop; other site 930781005466 ATP binding site [chemical binding]; other site 930781005467 Q-loop/lid; other site 930781005468 ABC transporter signature motif; other site 930781005469 Walker B; other site 930781005470 D-loop; other site 930781005471 H-loop/switch region; other site 930781005472 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 930781005473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781005474 active site 930781005475 phosphorylation site [posttranslational modification] 930781005476 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930781005477 active site 930781005478 P-loop; other site 930781005479 phosphorylation site [posttranslational modification] 930781005480 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930781005481 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930781005482 intersubunit interface [polypeptide binding]; other site 930781005483 active site 930781005484 zinc binding site [ion binding]; other site 930781005485 Na+ binding site [ion binding]; other site 930781005486 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781005487 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781005488 ligand binding site [chemical binding]; other site 930781005489 flexible hinge region; other site 930781005490 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930781005491 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781005492 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781005493 ligand binding site [chemical binding]; other site 930781005494 Amino acid permease; Region: AA_permease_2; pfam13520 930781005495 K+ potassium transporter; Region: K_trans; cl15781 930781005496 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781005497 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781005498 DNA binding site [nucleotide binding] 930781005499 domain linker motif; other site 930781005500 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930781005501 ligand binding site [chemical binding]; other site 930781005502 dimerization interface [polypeptide binding]; other site 930781005503 CAAX protease self-immunity; Region: Abi; cl00558 930781005504 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 930781005505 homodimer interface [polypeptide binding]; other site 930781005506 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 930781005507 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930781005508 active site 930781005509 homodimer interface [polypeptide binding]; other site 930781005510 catalytic site [active] 930781005511 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 930781005512 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781005513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005514 dimer interface [polypeptide binding]; other site 930781005515 conserved gate region; other site 930781005516 putative PBP binding loops; other site 930781005517 ABC-ATPase subunit interface; other site 930781005518 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781005519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005520 dimer interface [polypeptide binding]; other site 930781005521 conserved gate region; other site 930781005522 putative PBP binding loops; other site 930781005523 ABC-ATPase subunit interface; other site 930781005524 Predicted integral membrane protein [Function unknown]; Region: COG5521 930781005525 maltose phosphorylase; Provisional; Region: PRK13807 930781005526 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 930781005527 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 930781005528 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 930781005529 Uncharacterized conserved protein [Function unknown]; Region: COG1624 930781005530 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930781005531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 930781005532 YbbR-like protein; Region: YbbR; pfam07949 930781005533 YbbR-like protein; Region: YbbR; pfam07949 930781005534 YbbR-like protein; Region: YbbR; pfam07949 930781005535 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 930781005536 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 930781005537 active site 930781005538 substrate binding site [chemical binding]; other site 930781005539 metal binding site [ion binding]; metal-binding site 930781005540 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781005541 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781005542 Coenzyme A binding pocket [chemical binding]; other site 930781005543 FtsX-like permease family; Region: FtsX; pfam02687 930781005544 FtsX-like permease family; Region: FtsX; pfam02687 930781005545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781005546 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781005547 Walker A/P-loop; other site 930781005548 ATP binding site [chemical binding]; other site 930781005549 Q-loop/lid; other site 930781005550 ABC transporter signature motif; other site 930781005551 Walker B; other site 930781005552 D-loop; other site 930781005553 H-loop/switch region; other site 930781005554 putative heme peroxidase; Provisional; Region: PRK12276 930781005555 Helix-turn-helix domain; Region: HTH_17; pfam12728 930781005556 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930781005557 dimer interface [polypeptide binding]; other site 930781005558 FMN binding site [chemical binding]; other site 930781005559 NADPH bind site [chemical binding]; other site 930781005560 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 930781005561 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 930781005562 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930781005563 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930781005564 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930781005565 active site 930781005566 dimer interface [polypeptide binding]; other site 930781005567 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930781005568 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930781005569 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930781005570 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930781005571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930781005572 putative active site [active] 930781005573 putative metal binding site [ion binding]; other site 930781005574 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 930781005575 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 930781005576 G1 box; other site 930781005577 GTP/Mg2+ binding site [chemical binding]; other site 930781005578 Switch I region; other site 930781005579 G2 box; other site 930781005580 G3 box; other site 930781005581 Switch II region; other site 930781005582 G4 box; other site 930781005583 G5 box; other site 930781005584 Nucleoside recognition; Region: Gate; pfam07670 930781005585 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 930781005586 Nucleoside recognition; Region: Gate; pfam07670 930781005587 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 930781005588 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 930781005589 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 930781005590 conserved cys residue [active] 930781005591 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 930781005592 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 930781005593 active site 930781005594 multimer interface [polypeptide binding]; other site 930781005595 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930781005596 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781005597 DNA-binding site [nucleotide binding]; DNA binding site 930781005598 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781005599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781005600 homodimer interface [polypeptide binding]; other site 930781005601 catalytic residue [active] 930781005602 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930781005603 PRD domain; Region: PRD; pfam00874 930781005604 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930781005605 active site 930781005606 P-loop; other site 930781005607 phosphorylation site [posttranslational modification] 930781005608 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 930781005609 active site 930781005610 phosphorylation site [posttranslational modification] 930781005611 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930781005612 active site 930781005613 phosphorylation site [posttranslational modification] 930781005614 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 930781005615 active site 930781005616 P-loop; other site 930781005617 phosphorylation site [posttranslational modification] 930781005618 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930781005619 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930781005620 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930781005621 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930781005622 putative substrate binding site [chemical binding]; other site 930781005623 putative ATP binding site [chemical binding]; other site 930781005624 hypothetical protein; Provisional; Region: PRK06357 930781005625 active site 930781005626 intersubunit interface [polypeptide binding]; other site 930781005627 Zn2+ binding site [ion binding]; other site 930781005628 BCCT family transporter; Region: BCCT; pfam02028 930781005629 argininosuccinate lyase; Provisional; Region: PRK00855 930781005630 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 930781005631 active sites [active] 930781005632 tetramer interface [polypeptide binding]; other site 930781005633 argininosuccinate synthase; Provisional; Region: PRK13820 930781005634 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 930781005635 ANP binding site [chemical binding]; other site 930781005636 Substrate Binding Site II [chemical binding]; other site 930781005637 Substrate Binding Site I [chemical binding]; other site 930781005638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930781005639 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930781005640 substrate binding pocket [chemical binding]; other site 930781005641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781005642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781005643 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 930781005644 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930781005645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781005646 non-specific DNA binding site [nucleotide binding]; other site 930781005647 salt bridge; other site 930781005648 sequence-specific DNA binding site [nucleotide binding]; other site 930781005649 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005650 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005651 Cna protein B-type domain; Region: Cna_B; pfam05738 930781005652 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781005653 Phosphotransferase enzyme family; Region: APH; pfam01636 930781005654 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930781005655 active site 930781005656 substrate binding site [chemical binding]; other site 930781005657 ATP binding site [chemical binding]; other site 930781005658 Uncharacterized conserved protein [Function unknown]; Region: COG4832 930781005659 camphor resistance protein CrcB; Provisional; Region: PRK14231 930781005660 camphor resistance protein CrcB; Provisional; Region: PRK14214 930781005661 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 930781005662 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930781005663 Glycoprotease family; Region: Peptidase_M22; pfam00814 930781005664 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930781005665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781005666 Coenzyme A binding pocket [chemical binding]; other site 930781005667 UGMP family protein; Validated; Region: PRK09604 930781005668 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930781005669 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781005670 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930781005671 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930781005672 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781005673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781005674 ABC transporter; Region: ABC_tran_2; pfam12848 930781005675 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781005676 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 930781005677 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 930781005678 CoA binding domain; Region: CoA_binding; pfam02629 930781005679 CAAX protease self-immunity; Region: Abi; pfam02517 930781005680 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 930781005681 oligomerisation interface [polypeptide binding]; other site 930781005682 mobile loop; other site 930781005683 roof hairpin; other site 930781005684 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 930781005685 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 930781005686 ring oligomerisation interface [polypeptide binding]; other site 930781005687 ATP/Mg binding site [chemical binding]; other site 930781005688 stacking interactions; other site 930781005689 hinge regions; other site 930781005690 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 930781005691 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 930781005692 active site 930781005693 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 930781005694 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 930781005695 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 930781005696 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 930781005697 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 930781005698 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 930781005699 MOSC domain; Region: MOSC; pfam03473 930781005700 3-alpha domain; Region: 3-alpha; pfam03475 930781005701 Ion transport protein; Region: Ion_trans; pfam00520 930781005702 Ion channel; Region: Ion_trans_2; pfam07885 930781005703 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 930781005704 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 930781005705 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 930781005706 UbiA prenyltransferase family; Region: UbiA; pfam01040 930781005707 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 930781005708 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 930781005709 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 930781005710 hypothetical protein; Provisional; Region: PRK02886 930781005711 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 930781005712 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 930781005713 active site 930781005714 (T/H)XGH motif; other site 930781005715 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 930781005716 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 930781005717 protein binding site [polypeptide binding]; other site 930781005718 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930781005719 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930781005720 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930781005721 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 930781005722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781005723 Walker A/P-loop; other site 930781005724 ATP binding site [chemical binding]; other site 930781005725 Q-loop/lid; other site 930781005726 ABC transporter signature motif; other site 930781005727 Walker B; other site 930781005728 D-loop; other site 930781005729 H-loop/switch region; other site 930781005730 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 930781005731 hypothetical protein; Provisional; Region: PRK13670 930781005732 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 930781005733 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 930781005734 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 930781005735 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 930781005736 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 930781005737 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 930781005738 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 930781005739 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 930781005740 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 930781005741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 930781005742 MraZ protein; Region: MraZ; pfam02381 930781005743 MraZ protein; Region: MraZ; pfam02381 930781005744 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 930781005745 MraW methylase family; Region: Methyltransf_5; pfam01795 930781005746 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 930781005747 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930781005748 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930781005749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930781005750 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 930781005751 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 930781005752 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 930781005753 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930781005754 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930781005755 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930781005756 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 930781005757 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 930781005758 Mg++ binding site [ion binding]; other site 930781005759 putative catalytic motif [active] 930781005760 putative substrate binding site [chemical binding]; other site 930781005761 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 930781005762 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930781005763 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930781005764 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 930781005765 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930781005766 active site 930781005767 homodimer interface [polypeptide binding]; other site 930781005768 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 930781005769 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 930781005770 Cell division protein FtsQ; Region: FtsQ; pfam03799 930781005771 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 930781005772 Cell division protein FtsA; Region: FtsA; smart00842 930781005773 Cell division protein FtsA; Region: FtsA; pfam14450 930781005774 cell division protein FtsZ; Validated; Region: PRK09330 930781005775 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 930781005776 nucleotide binding site [chemical binding]; other site 930781005777 SulA interaction site; other site 930781005778 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 930781005779 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930781005780 catalytic residue [active] 930781005781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 930781005782 YGGT family; Region: YGGT; pfam02325 930781005783 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 930781005784 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781005785 RNA binding surface [nucleotide binding]; other site 930781005786 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781005787 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781005788 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930781005789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781005790 S-adenosylmethionine binding site [chemical binding]; other site 930781005791 Mga helix-turn-helix domain; Region: Mga; pfam05043 930781005792 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005793 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005794 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005795 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005796 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005797 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005798 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005799 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005800 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005801 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005802 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005803 Leucine rich repeat; Region: LRR_8; pfam13855 930781005804 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781005805 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005806 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005807 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005808 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005809 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005810 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005811 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005812 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005813 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005814 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781005815 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005816 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005817 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005818 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005819 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005820 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930781005821 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005822 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930781005823 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930781005824 quinolinate synthetase; Provisional; Region: PRK09375 930781005825 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 930781005826 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 930781005827 dimerization interface [polypeptide binding]; other site 930781005828 active site 930781005829 L-aspartate oxidase; Provisional; Region: PRK08071 930781005830 L-aspartate oxidase; Provisional; Region: PRK06175 930781005831 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930781005832 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 930781005833 HTH domain; Region: HTH_11; pfam08279 930781005834 3H domain; Region: 3H; pfam02829 930781005835 DivIVA protein; Region: DivIVA; pfam05103 930781005836 DivIVA domain; Region: DivI1A_domain; TIGR03544 930781005837 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 930781005838 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930781005839 active site 930781005840 HIGH motif; other site 930781005841 nucleotide binding site [chemical binding]; other site 930781005842 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930781005843 active site 930781005844 KMSKS motif; other site 930781005845 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 930781005846 tRNA binding surface [nucleotide binding]; other site 930781005847 anticodon binding site; other site 930781005848 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930781005849 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 930781005850 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930781005851 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930781005852 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930781005853 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930781005854 active site 930781005855 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930781005856 DNA-binding site [nucleotide binding]; DNA binding site 930781005857 RNA-binding motif; other site 930781005858 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930781005859 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 930781005860 active site 930781005861 catalytic site [active] 930781005862 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930781005863 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930781005864 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 930781005865 active site 930781005866 metal binding site [ion binding]; metal-binding site 930781005867 homodimer interface [polypeptide binding]; other site 930781005868 catalytic site [active] 930781005869 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930781005870 Uncharacterized conserved protein [Function unknown]; Region: COG3538 930781005871 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 930781005872 Predicted integral membrane protein [Function unknown]; Region: COG5578 930781005873 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 930781005874 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 930781005875 dimerization interface [polypeptide binding]; other site 930781005876 Histidine kinase; Region: His_kinase; pfam06580 930781005877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781005878 ATP binding site [chemical binding]; other site 930781005879 Mg2+ binding site [ion binding]; other site 930781005880 G-X-G motif; other site 930781005881 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 930781005882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781005883 active site 930781005884 phosphorylation site [posttranslational modification] 930781005885 intermolecular recognition site; other site 930781005886 dimerization interface [polypeptide binding]; other site 930781005887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781005888 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930781005889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005890 dimer interface [polypeptide binding]; other site 930781005891 conserved gate region; other site 930781005892 ABC-ATPase subunit interface; other site 930781005893 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781005894 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781005895 dimer interface [polypeptide binding]; other site 930781005896 conserved gate region; other site 930781005897 ABC-ATPase subunit interface; other site 930781005898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781005899 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930781005900 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 930781005901 acetolactate synthase; Reviewed; Region: PRK08617 930781005902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930781005903 PYR/PP interface [polypeptide binding]; other site 930781005904 dimer interface [polypeptide binding]; other site 930781005905 TPP binding site [chemical binding]; other site 930781005906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930781005907 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 930781005908 TPP-binding site [chemical binding]; other site 930781005909 dimer interface [polypeptide binding]; other site 930781005910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930781005911 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930781005912 active site 930781005913 catalytic tetrad [active] 930781005914 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781005915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781005916 DNA-binding site [nucleotide binding]; DNA binding site 930781005917 UTRA domain; Region: UTRA; pfam07702 930781005918 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930781005919 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781005920 DNA-binding site [nucleotide binding]; DNA binding site 930781005921 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930781005922 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930781005923 active site 930781005924 phosphorylation site [posttranslational modification] 930781005925 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 930781005926 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 930781005927 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930781005928 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930781005929 dimer interface [polypeptide binding]; other site 930781005930 active site 930781005931 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930781005932 dimer interface [polypeptide binding]; other site 930781005933 active site 930781005934 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930781005935 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 930781005936 putative active site [active] 930781005937 SIS domain; Region: SIS; pfam01380 930781005938 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781005939 active pocket/dimerization site; other site 930781005940 active site 930781005941 phosphorylation site [posttranslational modification] 930781005942 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930781005943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 930781005944 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930781005945 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 930781005946 intersubunit interface [polypeptide binding]; other site 930781005947 active site 930781005948 catalytic residue [active] 930781005949 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781005950 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781005951 DNA binding site [nucleotide binding] 930781005952 domain linker motif; other site 930781005953 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930781005954 dimerization interface [polypeptide binding]; other site 930781005955 ligand binding site [chemical binding]; other site 930781005956 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 930781005957 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930781005958 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930781005959 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 930781005960 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 930781005961 threonine dehydratase; Validated; Region: PRK08639 930781005962 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 930781005963 tetramer interface [polypeptide binding]; other site 930781005964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781005965 catalytic residue [active] 930781005966 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 930781005967 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 930781005968 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 930781005969 substrate binding site [chemical binding]; other site 930781005970 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 930781005971 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 930781005972 substrate binding site [chemical binding]; other site 930781005973 ligand binding site [chemical binding]; other site 930781005974 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 930781005975 tartrate dehydrogenase; Region: TTC; TIGR02089 930781005976 2-isopropylmalate synthase; Validated; Region: PRK00915 930781005977 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 930781005978 active site 930781005979 catalytic residues [active] 930781005980 metal binding site [ion binding]; metal-binding site 930781005981 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 930781005982 ketol-acid reductoisomerase; Provisional; Region: PRK05479 930781005983 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 930781005984 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 930781005985 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 930781005986 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 930781005987 putative valine binding site [chemical binding]; other site 930781005988 dimer interface [polypeptide binding]; other site 930781005989 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 930781005990 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 930781005991 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930781005992 PYR/PP interface [polypeptide binding]; other site 930781005993 dimer interface [polypeptide binding]; other site 930781005994 TPP binding site [chemical binding]; other site 930781005995 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930781005996 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 930781005997 TPP-binding site [chemical binding]; other site 930781005998 dimer interface [polypeptide binding]; other site 930781005999 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 930781006000 6-phosphogluconate dehydratase; Region: edd; TIGR01196 930781006001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930781006002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781006003 Coenzyme A binding pocket [chemical binding]; other site 930781006004 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 930781006005 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 930781006006 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 930781006007 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 930781006008 ribonuclease Z; Region: RNase_Z; TIGR02651 930781006009 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 930781006010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930781006011 NAD(P) binding site [chemical binding]; other site 930781006012 active site 930781006013 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 930781006014 active site 930781006015 DNA polymerase IV; Validated; Region: PRK02406 930781006016 DNA binding site [nucleotide binding] 930781006017 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 930781006018 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 930781006019 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 930781006020 dimer interface [polypeptide binding]; other site 930781006021 ADP-ribose binding site [chemical binding]; other site 930781006022 active site 930781006023 nudix motif; other site 930781006024 metal binding site [ion binding]; metal-binding site 930781006025 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781006026 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930781006027 Walker A/P-loop; other site 930781006028 ATP binding site [chemical binding]; other site 930781006029 Q-loop/lid; other site 930781006030 ABC transporter signature motif; other site 930781006031 Walker B; other site 930781006032 D-loop; other site 930781006033 H-loop/switch region; other site 930781006034 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 930781006035 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930781006036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781006037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781006038 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930781006039 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930781006040 Walker A/P-loop; other site 930781006041 ATP binding site [chemical binding]; other site 930781006042 Q-loop/lid; other site 930781006043 ABC transporter signature motif; other site 930781006044 Walker B; other site 930781006045 D-loop; other site 930781006046 H-loop/switch region; other site 930781006047 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930781006048 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930781006049 putative ligand binding residues [chemical binding]; other site 930781006050 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930781006051 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781006052 ABC-ATPase subunit interface; other site 930781006053 dimer interface [polypeptide binding]; other site 930781006054 putative PBP binding regions; other site 930781006055 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930781006056 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781006057 ABC-ATPase subunit interface; other site 930781006058 dimer interface [polypeptide binding]; other site 930781006059 putative PBP binding regions; other site 930781006060 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930781006061 metal binding site 2 [ion binding]; metal-binding site 930781006062 putative DNA binding helix; other site 930781006063 metal binding site 1 [ion binding]; metal-binding site 930781006064 dimer interface [polypeptide binding]; other site 930781006065 structural Zn2+ binding site [ion binding]; other site 930781006066 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 930781006067 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930781006068 active site 930781006069 Int/Topo IB signature motif; other site 930781006070 phosphopentomutase; Provisional; Region: PRK05362 930781006071 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 930781006072 purine nucleoside phosphorylase; Provisional; Region: PRK08202 930781006073 diaminopimelate decarboxylase; Region: lysA; TIGR01048 930781006074 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 930781006075 active site 930781006076 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930781006077 substrate binding site [chemical binding]; other site 930781006078 catalytic residues [active] 930781006079 dimer interface [polypeptide binding]; other site 930781006080 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 930781006081 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 930781006082 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930781006083 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781006084 RNA binding surface [nucleotide binding]; other site 930781006085 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 930781006086 active site 930781006087 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781006088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781006089 active site 930781006090 phosphorylation site [posttranslational modification] 930781006091 intermolecular recognition site; other site 930781006092 dimerization interface [polypeptide binding]; other site 930781006093 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781006094 DNA binding site [nucleotide binding] 930781006095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930781006096 dimerization interface [polypeptide binding]; other site 930781006097 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930781006098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781006099 dimer interface [polypeptide binding]; other site 930781006100 phosphorylation site [posttranslational modification] 930781006101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781006102 ATP binding site [chemical binding]; other site 930781006103 Mg2+ binding site [ion binding]; other site 930781006104 G-X-G motif; other site 930781006105 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930781006106 Predicted membrane protein [Function unknown]; Region: COG3601 930781006107 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930781006108 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 930781006109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781006110 ATP binding site [chemical binding]; other site 930781006111 putative Mg++ binding site [ion binding]; other site 930781006112 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781006113 nucleotide binding region [chemical binding]; other site 930781006114 ATP-binding site [chemical binding]; other site 930781006115 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930781006116 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 930781006117 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 930781006118 active site 930781006119 homotetramer interface [polypeptide binding]; other site 930781006120 homodimer interface [polypeptide binding]; other site 930781006121 cytidylate kinase; Provisional; Region: cmk; PRK00023 930781006122 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 930781006123 CMP-binding site; other site 930781006124 The sites determining sugar specificity; other site 930781006125 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 930781006126 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 930781006127 RNA binding site [nucleotide binding]; other site 930781006128 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 930781006129 RNA binding site [nucleotide binding]; other site 930781006130 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 930781006131 RNA binding site [nucleotide binding]; other site 930781006132 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930781006133 RNA binding site [nucleotide binding]; other site 930781006134 GTP-binding protein Der; Reviewed; Region: PRK00093 930781006135 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 930781006136 G1 box; other site 930781006137 GTP/Mg2+ binding site [chemical binding]; other site 930781006138 Switch I region; other site 930781006139 G2 box; other site 930781006140 Switch II region; other site 930781006141 G3 box; other site 930781006142 G4 box; other site 930781006143 G5 box; other site 930781006144 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 930781006145 G1 box; other site 930781006146 GTP/Mg2+ binding site [chemical binding]; other site 930781006147 Switch I region; other site 930781006148 G2 box; other site 930781006149 G3 box; other site 930781006150 Switch II region; other site 930781006151 G4 box; other site 930781006152 G5 box; other site 930781006153 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 930781006154 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930781006155 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 930781006156 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 930781006157 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 930781006158 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930781006159 IHF dimer interface [polypeptide binding]; other site 930781006160 IHF - DNA interface [nucleotide binding]; other site 930781006161 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 930781006162 homodecamer interface [polypeptide binding]; other site 930781006163 GTP cyclohydrolase I; Provisional; Region: PLN03044 930781006164 active site 930781006165 putative catalytic site residues [active] 930781006166 zinc binding site [ion binding]; other site 930781006167 GTP-CH-I/GFRP interaction surface; other site 930781006168 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 930781006169 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 930781006170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781006171 S-adenosylmethionine binding site [chemical binding]; other site 930781006172 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930781006173 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930781006174 substrate binding pocket [chemical binding]; other site 930781006175 chain length determination region; other site 930781006176 substrate-Mg2+ binding site; other site 930781006177 catalytic residues [active] 930781006178 aspartate-rich region 1; other site 930781006179 active site lid residues [active] 930781006180 aspartate-rich region 2; other site 930781006181 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 930781006182 active site 930781006183 multimer interface [polypeptide binding]; other site 930781006184 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 930781006185 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 930781006186 Tetramer interface [polypeptide binding]; other site 930781006187 active site 930781006188 FMN-binding site [chemical binding]; other site 930781006189 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 930781006190 active site 930781006191 dimer interface [polypeptide binding]; other site 930781006192 metal binding site [ion binding]; metal-binding site 930781006193 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 930781006194 homotrimer interaction site [polypeptide binding]; other site 930781006195 active site 930781006196 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 930781006197 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781006198 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781006199 homodimer interface [polypeptide binding]; other site 930781006200 catalytic residue [active] 930781006201 prephenate dehydrogenase; Validated; Region: PRK06545 930781006202 prephenate dehydrogenase; Validated; Region: PRK08507 930781006203 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 930781006204 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 930781006205 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 930781006206 hinge; other site 930781006207 active site 930781006208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930781006209 binding surface 930781006210 TPR motif; other site 930781006211 TPR repeat; Region: TPR_11; pfam13414 930781006212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781006213 binding surface 930781006214 TPR motif; other site 930781006215 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930781006216 binding surface 930781006217 TPR motif; other site 930781006218 hypothetical protein; Provisional; Region: PRK03636 930781006219 UPF0302 domain; Region: UPF0302; pfam08864 930781006220 IDEAL domain; Region: IDEAL; pfam08858 930781006221 Predicted membrane protein [Function unknown]; Region: COG4347 930781006222 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 930781006223 HI0933-like protein; Region: HI0933_like; pfam03486 930781006224 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781006225 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 930781006226 Pyruvate formate lyase 1; Region: PFL1; cd01678 930781006227 coenzyme A binding site [chemical binding]; other site 930781006228 active site 930781006229 catalytic residues [active] 930781006230 glycine loop; other site 930781006231 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930781006232 Beta-lactamase; Region: Beta-lactamase; pfam00144 930781006233 malate dehydrogenase; Provisional; Region: PRK13529 930781006234 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930781006235 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 930781006236 NAD(P) binding pocket [chemical binding]; other site 930781006237 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930781006238 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930781006239 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930781006240 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930781006241 metal binding site [ion binding]; metal-binding site 930781006242 active site 930781006243 I-site; other site 930781006244 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930781006245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930781006246 metal binding site [ion binding]; metal-binding site 930781006247 active site 930781006248 I-site; other site 930781006249 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930781006250 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930781006251 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781006252 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781006253 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781006254 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 930781006255 homodimer interface [polypeptide binding]; other site 930781006256 metal binding site [ion binding]; metal-binding site 930781006257 dihydrodipicolinate reductase; Provisional; Region: PRK00048 930781006258 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 930781006259 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 930781006260 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 930781006261 active site 930781006262 dimer interfaces [polypeptide binding]; other site 930781006263 catalytic residues [active] 930781006264 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 930781006265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 930781006266 active site 930781006267 NTP binding site [chemical binding]; other site 930781006268 metal binding triad [ion binding]; metal-binding site 930781006269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 930781006270 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 930781006271 Biotin operon repressor [Transcription]; Region: BirA; COG1654 930781006272 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 930781006273 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 930781006274 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 930781006275 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781006276 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930781006277 catalytic residues [active] 930781006278 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 930781006279 active site 930781006280 oligomerization interface [polypeptide binding]; other site 930781006281 metal binding site [ion binding]; metal-binding site 930781006282 pantoate--beta-alanine ligase; Region: panC; TIGR00018 930781006283 Pantoate-beta-alanine ligase; Region: PanC; cd00560 930781006284 active site 930781006285 ATP-binding site [chemical binding]; other site 930781006286 pantoate-binding site; other site 930781006287 HXXH motif; other site 930781006288 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 930781006289 tetramerization interface [polypeptide binding]; other site 930781006290 active site 930781006291 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 930781006292 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930781006293 active site 930781006294 catalytic site [active] 930781006295 substrate binding site [chemical binding]; other site 930781006296 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 930781006297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930781006298 putative Mg++ binding site [ion binding]; other site 930781006299 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930781006300 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 930781006301 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930781006302 aspartate aminotransferase; Provisional; Region: PRK05764 930781006303 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781006304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781006305 homodimer interface [polypeptide binding]; other site 930781006306 catalytic residue [active] 930781006307 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 930781006308 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 930781006309 putative dimer interface [polypeptide binding]; other site 930781006310 putative anticodon binding site; other site 930781006311 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 930781006312 homodimer interface [polypeptide binding]; other site 930781006313 motif 1; other site 930781006314 motif 2; other site 930781006315 active site 930781006316 motif 3; other site 930781006317 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 930781006318 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930781006319 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 930781006320 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930781006321 minor groove reading motif; other site 930781006322 helix-hairpin-helix signature motif; other site 930781006323 substrate binding pocket [chemical binding]; other site 930781006324 active site 930781006325 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 930781006326 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 930781006327 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 930781006328 hypothetical protein; Provisional; Region: PRK13660 930781006329 cell division protein GpsB; Provisional; Region: PRK14127 930781006330 DivIVA domain; Region: DivI1A_domain; TIGR03544 930781006331 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 930781006332 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 930781006333 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 930781006334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930781006335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781006336 active site 930781006337 xanthine permease; Region: pbuX; TIGR03173 930781006338 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 930781006339 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 930781006340 putative active site [active] 930781006341 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 930781006342 5'-3' exonuclease; Region: 53EXOc; smart00475 930781006343 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930781006344 active site 930781006345 metal binding site 1 [ion binding]; metal-binding site 930781006346 putative 5' ssDNA interaction site; other site 930781006347 metal binding site 3; metal-binding site 930781006348 metal binding site 2 [ion binding]; metal-binding site 930781006349 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930781006350 putative DNA binding site [nucleotide binding]; other site 930781006351 putative metal binding site [ion binding]; other site 930781006352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930781006353 DNA-binding site [nucleotide binding]; DNA binding site 930781006354 RNA-binding motif; other site 930781006355 manganese transport transcriptional regulator; Provisional; Region: PRK03902 930781006356 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 930781006357 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930781006358 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 930781006359 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 930781006360 Potassium binding sites [ion binding]; other site 930781006361 Cesium cation binding sites [ion binding]; other site 930781006362 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930781006363 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930781006364 Walker A/P-loop; other site 930781006365 ATP binding site [chemical binding]; other site 930781006366 Q-loop/lid; other site 930781006367 ABC transporter signature motif; other site 930781006368 Walker B; other site 930781006369 D-loop; other site 930781006370 H-loop/switch region; other site 930781006371 ABC transporter; Region: ABC_tran_2; pfam12848 930781006372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930781006373 thymidylate synthase; Region: thym_sym; TIGR03284 930781006374 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 930781006375 dimerization interface [polypeptide binding]; other site 930781006376 active site 930781006377 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930781006378 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 930781006379 folate binding site [chemical binding]; other site 930781006380 NADP+ binding site [chemical binding]; other site 930781006381 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 930781006382 active site 930781006383 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 930781006384 substrate binding site [chemical binding]; other site 930781006385 metal binding site [ion binding]; metal-binding site 930781006386 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 930781006387 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 930781006388 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 930781006389 Clostridial hydrophobic W; Region: ChW; pfam07538 930781006390 Clostridial hydrophobic W; Region: ChW; pfam07538 930781006391 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930781006392 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930781006393 Predicted membrane protein [Function unknown]; Region: COG4129 930781006394 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930781006395 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 930781006396 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781006397 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930781006398 pyruvate phosphate dikinase; Provisional; Region: PRK09279 930781006399 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930781006400 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930781006401 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930781006402 PEP synthetase regulatory protein; Provisional; Region: PRK05339 930781006403 HTH domain; Region: HTH_11; pfam08279 930781006404 FOG: CBS domain [General function prediction only]; Region: COG0517 930781006405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 930781006406 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 930781006407 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 930781006408 EDD domain protein, DegV family; Region: DegV; TIGR00762 930781006409 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930781006410 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 930781006411 active site 930781006412 catalytic triad [active] 930781006413 oxyanion hole [active] 930781006414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 930781006415 methionine sulfoxide reductase A; Provisional; Region: PRK14054 930781006416 methionine sulfoxide reductase B; Provisional; Region: PRK00222 930781006417 SelR domain; Region: SelR; pfam01641 930781006418 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781006419 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781006420 hypothetical protein; Provisional; Region: PRK13672 930781006421 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 930781006422 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 930781006423 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 930781006424 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930781006425 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 930781006426 putative homodimer interface [polypeptide binding]; other site 930781006427 putative homotetramer interface [polypeptide binding]; other site 930781006428 putative allosteric switch controlling residues; other site 930781006429 putative metal binding site [ion binding]; other site 930781006430 putative homodimer-homodimer interface [polypeptide binding]; other site 930781006431 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930781006432 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930781006433 metal-binding site [ion binding] 930781006434 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930781006435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781006436 motif II; other site 930781006437 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930781006438 metal-binding site [ion binding] 930781006439 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 930781006440 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 930781006441 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 930781006442 protein binding site [polypeptide binding]; other site 930781006443 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 930781006444 Catalytic dyad [active] 930781006445 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 930781006446 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781006447 MarR family; Region: MarR; pfam01047 930781006448 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930781006449 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930781006450 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930781006451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781006452 ABC-ATPase subunit interface; other site 930781006453 dimer interface [polypeptide binding]; other site 930781006454 putative PBP binding regions; other site 930781006455 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 930781006456 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 930781006457 metal binding site [ion binding]; metal-binding site 930781006458 multidrug efflux protein; Reviewed; Region: PRK01766 930781006459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 930781006460 cation binding site [ion binding]; other site 930781006461 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930781006462 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930781006463 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 930781006464 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930781006465 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781006466 RNA binding surface [nucleotide binding]; other site 930781006467 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930781006468 active site 930781006469 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781006470 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930781006471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781006472 active site 930781006473 uracil transporter; Provisional; Region: PRK10720 930781006474 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 930781006475 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930781006476 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930781006477 dihydroorotase; Validated; Region: pyrC; PRK09357 930781006478 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930781006479 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 930781006480 active site 930781006481 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 930781006482 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 930781006483 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 930781006484 catalytic site [active] 930781006485 subunit interface [polypeptide binding]; other site 930781006486 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 930781006487 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930781006488 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930781006489 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 930781006490 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930781006491 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930781006492 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 930781006493 IMP binding site; other site 930781006494 dimer interface [polypeptide binding]; other site 930781006495 interdomain contacts; other site 930781006496 partial ornithine binding site; other site 930781006497 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 930781006498 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 930781006499 FAD binding pocket [chemical binding]; other site 930781006500 FAD binding motif [chemical binding]; other site 930781006501 phosphate binding motif [ion binding]; other site 930781006502 beta-alpha-beta structure motif; other site 930781006503 NAD binding pocket [chemical binding]; other site 930781006504 Iron coordination center [ion binding]; other site 930781006505 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 930781006506 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 930781006507 heterodimer interface [polypeptide binding]; other site 930781006508 active site 930781006509 FMN binding site [chemical binding]; other site 930781006510 homodimer interface [polypeptide binding]; other site 930781006511 substrate binding site [chemical binding]; other site 930781006512 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 930781006513 active site 930781006514 dimer interface [polypeptide binding]; other site 930781006515 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781006516 active site 930781006517 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 930781006518 putative NAD(P) binding site [chemical binding]; other site 930781006519 homodimer interface [polypeptide binding]; other site 930781006520 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 930781006521 Domain of unknown function (DUF814); Region: DUF814; pfam05670 930781006522 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 930781006523 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 930781006524 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 930781006525 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 930781006526 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 930781006527 catalytic site [active] 930781006528 G-X2-G-X-G-K; other site 930781006529 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 930781006530 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 930781006531 Flavoprotein; Region: Flavoprotein; pfam02441 930781006532 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 930781006533 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 930781006534 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 930781006535 putative active site [active] 930781006536 substrate binding site [chemical binding]; other site 930781006537 putative cosubstrate binding site; other site 930781006538 catalytic site [active] 930781006539 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 930781006540 substrate binding site [chemical binding]; other site 930781006541 16S rRNA methyltransferase B; Provisional; Region: PRK14902 930781006542 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 930781006543 putative RNA binding site [nucleotide binding]; other site 930781006544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781006545 S-adenosylmethionine binding site [chemical binding]; other site 930781006546 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 930781006547 Protein phosphatase 2C; Region: PP2C; pfam00481 930781006548 active site 930781006549 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930781006550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930781006551 active site 930781006552 ATP binding site [chemical binding]; other site 930781006553 substrate binding site [chemical binding]; other site 930781006554 activation loop (A-loop); other site 930781006555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 930781006556 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930781006557 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930781006558 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930781006559 GTPase RsgA; Reviewed; Region: PRK00098 930781006560 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 930781006561 RNA binding site [nucleotide binding]; other site 930781006562 homodimer interface [polypeptide binding]; other site 930781006563 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930781006564 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930781006565 GTP/Mg2+ binding site [chemical binding]; other site 930781006566 G4 box; other site 930781006567 G1 box; other site 930781006568 Switch I region; other site 930781006569 G2 box; other site 930781006570 G3 box; other site 930781006571 Switch II region; other site 930781006572 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930781006573 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930781006574 substrate binding site [chemical binding]; other site 930781006575 hexamer interface [polypeptide binding]; other site 930781006576 metal binding site [ion binding]; metal-binding site 930781006577 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 930781006578 Thiamine pyrophosphokinase; Region: TPK; cd07995 930781006579 active site 930781006580 dimerization interface [polypeptide binding]; other site 930781006581 thiamine binding site [chemical binding]; other site 930781006582 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 930781006583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 930781006584 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 930781006585 DAK2 domain; Region: Dak2; pfam02734 930781006586 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 930781006587 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930781006588 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 930781006589 putative L-serine binding site [chemical binding]; other site 930781006590 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 930781006591 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 930781006592 Y-family of DNA polymerases; Region: PolY; cl12025 930781006593 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 930781006594 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 930781006595 generic binding surface II; other site 930781006596 ssDNA binding site; other site 930781006597 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930781006598 ATP binding site [chemical binding]; other site 930781006599 putative Mg++ binding site [ion binding]; other site 930781006600 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781006601 nucleotide binding region [chemical binding]; other site 930781006602 ATP-binding site [chemical binding]; other site 930781006603 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 930781006604 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 930781006605 active site 2 [active] 930781006606 active site 1 [active] 930781006607 putative phosphate acyltransferase; Provisional; Region: PRK05331 930781006608 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930781006609 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 930781006610 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930781006611 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930781006612 NAD(P) binding site [chemical binding]; other site 930781006613 homotetramer interface [polypeptide binding]; other site 930781006614 homodimer interface [polypeptide binding]; other site 930781006615 active site 930781006616 acyl carrier protein; Provisional; Region: acpP; PRK00982 930781006617 ribonuclease III; Reviewed; Region: rnc; PRK00102 930781006618 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930781006619 dimerization interface [polypeptide binding]; other site 930781006620 active site 930781006621 metal binding site [ion binding]; metal-binding site 930781006622 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 930781006623 dsRNA binding site [nucleotide binding]; other site 930781006624 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 930781006625 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930781006626 Walker A/P-loop; other site 930781006627 ATP binding site [chemical binding]; other site 930781006628 Q-loop/lid; other site 930781006629 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 930781006630 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 930781006631 linker region; other site 930781006632 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930781006633 ABC transporter signature motif; other site 930781006634 Walker B; other site 930781006635 D-loop; other site 930781006636 H-loop/switch region; other site 930781006637 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 930781006638 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 930781006639 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930781006640 P loop; other site 930781006641 GTP binding site [chemical binding]; other site 930781006642 putative DNA-binding protein; Validated; Region: PRK00118 930781006643 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 930781006644 signal recognition particle protein; Provisional; Region: PRK10867 930781006645 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 930781006646 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930781006647 P loop; other site 930781006648 GTP binding site [chemical binding]; other site 930781006649 Signal peptide binding domain; Region: SRP_SPB; pfam02978 930781006650 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 930781006651 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 930781006652 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 930781006653 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 930781006654 KH domain; Region: KH_4; pfam13083 930781006655 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 930781006656 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 930781006657 catalytic triad [active] 930781006658 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 930781006659 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 930781006660 RimM N-terminal domain; Region: RimM; pfam01782 930781006661 PRC-barrel domain; Region: PRC; pfam05239 930781006662 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 930781006663 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 930781006664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781006665 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930781006666 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930781006667 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 930781006668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930781006669 DNA binding residues [nucleotide binding] 930781006670 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 930781006671 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781006672 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930781006673 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930781006674 Substrate binding site [chemical binding]; other site 930781006675 Leucine rich repeat; Region: LRR_8; pfam13855 930781006676 LRR adjacent; Region: LRR_adjacent; pfam08191 930781006677 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 930781006678 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 930781006679 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 930781006680 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 930781006681 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 930781006682 23S rRNA binding site [nucleotide binding]; other site 930781006683 L21 binding site [polypeptide binding]; other site 930781006684 L13 binding site [polypeptide binding]; other site 930781006685 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 930781006686 active site 930781006687 putative catalytic site [active] 930781006688 DNA binding site [nucleotide binding] 930781006689 putative phosphate binding site [ion binding]; other site 930781006690 metal binding site A [ion binding]; metal-binding site 930781006691 AP binding site [nucleotide binding]; other site 930781006692 metal binding site B [ion binding]; metal-binding site 930781006693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 930781006694 peptidase T; Region: peptidase-T; TIGR01882 930781006695 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 930781006696 metal binding site [ion binding]; metal-binding site 930781006697 dimer interface [polypeptide binding]; other site 930781006698 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930781006699 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930781006700 Walker A/P-loop; other site 930781006701 ATP binding site [chemical binding]; other site 930781006702 Q-loop/lid; other site 930781006703 ABC transporter signature motif; other site 930781006704 Walker B; other site 930781006705 D-loop; other site 930781006706 H-loop/switch region; other site 930781006707 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 930781006708 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781006709 Zn2+ binding site [ion binding]; other site 930781006710 Mg2+ binding site [ion binding]; other site 930781006711 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 930781006712 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781006713 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 930781006714 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930781006715 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 930781006716 NAD binding site [chemical binding]; other site 930781006717 ATP-grasp domain; Region: ATP-grasp; pfam02222 930781006718 adenylosuccinate lyase; Provisional; Region: PRK07492 930781006719 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 930781006720 tetramer interface [polypeptide binding]; other site 930781006721 active site 930781006722 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 930781006723 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 930781006724 ATP binding site [chemical binding]; other site 930781006725 active site 930781006726 substrate binding site [chemical binding]; other site 930781006727 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 930781006728 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 930781006729 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 930781006730 putative active site [active] 930781006731 catalytic triad [active] 930781006732 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 930781006733 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 930781006734 dimerization interface [polypeptide binding]; other site 930781006735 ATP binding site [chemical binding]; other site 930781006736 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 930781006737 dimerization interface [polypeptide binding]; other site 930781006738 ATP binding site [chemical binding]; other site 930781006739 amidophosphoribosyltransferase; Provisional; Region: PRK06781 930781006740 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 930781006741 active site 930781006742 tetramer interface [polypeptide binding]; other site 930781006743 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781006744 active site 930781006745 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 930781006746 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 930781006747 dimerization interface [polypeptide binding]; other site 930781006748 putative ATP binding site [chemical binding]; other site 930781006749 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 930781006750 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 930781006751 active site 930781006752 substrate binding site [chemical binding]; other site 930781006753 cosubstrate binding site; other site 930781006754 catalytic site [active] 930781006755 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 930781006756 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 930781006757 purine monophosphate binding site [chemical binding]; other site 930781006758 dimer interface [polypeptide binding]; other site 930781006759 putative catalytic residues [active] 930781006760 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 930781006761 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 930781006762 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 930781006763 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 930781006764 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 930781006765 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 930781006766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 930781006767 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 930781006768 Na2 binding site [ion binding]; other site 930781006769 putative substrate binding site 1 [chemical binding]; other site 930781006770 Na binding site 1 [ion binding]; other site 930781006771 putative substrate binding site 2 [chemical binding]; other site 930781006772 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 930781006773 PcrB family; Region: PcrB; pfam01884 930781006774 substrate binding site [chemical binding]; other site 930781006775 putative active site [active] 930781006776 dimer interface [polypeptide binding]; other site 930781006777 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 930781006778 Part of AAA domain; Region: AAA_19; pfam13245 930781006779 Family description; Region: UvrD_C_2; pfam13538 930781006780 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 930781006781 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 930781006782 nucleotide binding pocket [chemical binding]; other site 930781006783 K-X-D-G motif; other site 930781006784 catalytic site [active] 930781006785 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 930781006786 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 930781006787 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 930781006788 Dimer interface [polypeptide binding]; other site 930781006789 BRCT sequence motif; other site 930781006790 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 930781006791 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 930781006792 putative dimer interface [polypeptide binding]; other site 930781006793 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 930781006794 putative dimer interface [polypeptide binding]; other site 930781006795 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 930781006796 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930781006797 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 930781006798 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 930781006799 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 930781006800 GatB domain; Region: GatB_Yqey; smart00845 930781006801 putative lipid kinase; Reviewed; Region: PRK13337 930781006802 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930781006803 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 930781006804 TRAM domain; Region: TRAM; pfam01938 930781006805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781006806 S-adenosylmethionine binding site [chemical binding]; other site 930781006807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 930781006808 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 930781006809 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 930781006810 ADP binding site [chemical binding]; other site 930781006811 magnesium binding site [ion binding]; other site 930781006812 putative shikimate binding site; other site 930781006813 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781006814 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781006815 Walker A/P-loop; other site 930781006816 ATP binding site [chemical binding]; other site 930781006817 Q-loop/lid; other site 930781006818 ABC transporter signature motif; other site 930781006819 Walker B; other site 930781006820 D-loop; other site 930781006821 H-loop/switch region; other site 930781006822 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781006823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781006824 active site 930781006825 phosphorylation site [posttranslational modification] 930781006826 intermolecular recognition site; other site 930781006827 dimerization interface [polypeptide binding]; other site 930781006828 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781006829 DNA binding site [nucleotide binding] 930781006830 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930781006831 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 930781006832 putative NAD(P) binding site [chemical binding]; other site 930781006833 active site 930781006834 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 930781006835 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930781006836 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 930781006837 active site 930781006838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930781006839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 930781006840 dimer interface [polypeptide binding]; other site 930781006841 phosphorylation site [posttranslational modification] 930781006842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781006843 ATP binding site [chemical binding]; other site 930781006844 Mg2+ binding site [ion binding]; other site 930781006845 G-X-G motif; other site 930781006846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781006847 dimer interface [polypeptide binding]; other site 930781006848 conserved gate region; other site 930781006849 putative PBP binding loops; other site 930781006850 ABC-ATPase subunit interface; other site 930781006851 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930781006852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781006853 Q-loop/lid; other site 930781006854 ABC transporter signature motif; other site 930781006855 Walker B; other site 930781006856 D-loop; other site 930781006857 H-loop/switch region; other site 930781006858 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930781006859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930781006860 substrate binding pocket [chemical binding]; other site 930781006861 membrane-bound complex binding site; other site 930781006862 hinge residues; other site 930781006863 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 930781006864 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 930781006865 putative active site [active] 930781006866 metal binding site [ion binding]; metal-binding site 930781006867 Predicted acetyltransferase [General function prediction only]; Region: COG3153 930781006868 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930781006869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930781006870 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930781006871 putative dimerization interface [polypeptide binding]; other site 930781006872 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 930781006873 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930781006874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930781006875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781006876 dimer interface [polypeptide binding]; other site 930781006877 conserved gate region; other site 930781006878 putative PBP binding loops; other site 930781006879 ABC-ATPase subunit interface; other site 930781006880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781006881 dimer interface [polypeptide binding]; other site 930781006882 conserved gate region; other site 930781006883 putative PBP binding loops; other site 930781006884 ABC-ATPase subunit interface; other site 930781006885 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930781006886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930781006887 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 930781006888 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930781006889 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930781006890 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 930781006891 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930781006892 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930781006893 DNA binding site [nucleotide binding] 930781006894 domain linker motif; other site 930781006895 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930781006896 dimerization interface [polypeptide binding]; other site 930781006897 ligand binding site [chemical binding]; other site 930781006898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930781006899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930781006900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930781006901 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930781006902 ATP binding site [chemical binding]; other site 930781006903 putative Mg++ binding site [ion binding]; other site 930781006904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781006905 nucleotide binding region [chemical binding]; other site 930781006906 ATP-binding site [chemical binding]; other site 930781006907 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930781006908 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 930781006909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781006910 Walker A motif; other site 930781006911 ATP binding site [chemical binding]; other site 930781006912 Walker B motif; other site 930781006913 arginine finger; other site 930781006914 Transcriptional antiterminator [Transcription]; Region: COG3933 930781006915 PRD domain; Region: PRD; pfam00874 930781006916 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930781006917 active pocket/dimerization site; other site 930781006918 active site 930781006919 phosphorylation site [posttranslational modification] 930781006920 PRD domain; Region: PRD; pfam00874 930781006921 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930781006922 active site 930781006923 P-loop; other site 930781006924 phosphorylation site [posttranslational modification] 930781006925 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930781006926 methionine cluster; other site 930781006927 active site 930781006928 phosphorylation site [posttranslational modification] 930781006929 metal binding site [ion binding]; metal-binding site 930781006930 Uncharacterized conserved protein [Function unknown]; Region: COG3589 930781006931 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 930781006932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930781006933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930781006934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781006935 S-adenosylmethionine binding site [chemical binding]; other site 930781006936 rod-share determining protein MreBH; Provisional; Region: PRK13929 930781006937 MreB and similar proteins; Region: MreB_like; cd10225 930781006938 nucleotide binding site [chemical binding]; other site 930781006939 Mg binding site [ion binding]; other site 930781006940 putative protofilament interaction site [polypeptide binding]; other site 930781006941 RodZ interaction site [polypeptide binding]; other site 930781006942 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781006943 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781006944 putative substrate translocation pore; other site 930781006945 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930781006946 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930781006947 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 930781006948 flavodoxin, short chain; Region: flav_short; TIGR01753 930781006949 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930781006950 active site 930781006951 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 930781006952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 930781006953 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 930781006954 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 930781006955 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 930781006956 Substrate-binding site [chemical binding]; other site 930781006957 Substrate specificity [chemical binding]; other site 930781006958 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 930781006959 TRAM domain; Region: TRAM; cl01282 930781006960 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 930781006961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781006962 S-adenosylmethionine binding site [chemical binding]; other site 930781006963 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 930781006964 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 930781006965 dimer interface [polypeptide binding]; other site 930781006966 active site 930781006967 Mn binding site [ion binding]; other site 930781006968 PAS fold; Region: PAS_4; pfam08448 930781006969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930781006970 putative active site [active] 930781006971 heme pocket [chemical binding]; other site 930781006972 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930781006973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930781006974 dimer interface [polypeptide binding]; other site 930781006975 putative CheW interface [polypeptide binding]; other site 930781006976 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930781006977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930781006978 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930781006979 Cation efflux family; Region: Cation_efflux; pfam01545 930781006980 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930781006981 Predicted integral membrane protein [Function unknown]; Region: COG0392 930781006982 Uncharacterized conserved protein [Function unknown]; Region: COG2898 930781006983 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 930781006984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930781006985 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 930781006986 NAD(P) binding site [chemical binding]; other site 930781006987 active site 930781006988 WVELL protein; Region: WVELL; pfam14043 930781006989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 930781006990 trimer interface [polypeptide binding]; other site 930781006991 active site 930781006992 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 930781006993 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 930781006994 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 930781006995 putative NAD(P) binding site [chemical binding]; other site 930781006996 active site 930781006997 hypothetical protein; Provisional; Region: PRK13662 930781006998 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 930781006999 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930781007000 inhibitor-cofactor binding pocket; inhibition site 930781007001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007002 catalytic residue [active] 930781007003 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930781007004 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930781007005 NAD binding site [chemical binding]; other site 930781007006 ferric uptake regulator; Provisional; Region: fur; PRK09462 930781007007 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930781007008 metal binding site 2 [ion binding]; metal-binding site 930781007009 putative DNA binding helix; other site 930781007010 metal binding site 1 [ion binding]; metal-binding site 930781007011 dimer interface [polypeptide binding]; other site 930781007012 structural Zn2+ binding site [ion binding]; other site 930781007013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781007014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781007015 putative substrate translocation pore; other site 930781007016 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 930781007017 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 930781007018 THF binding site; other site 930781007019 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930781007020 substrate binding site [chemical binding]; other site 930781007021 THF binding site; other site 930781007022 zinc-binding site [ion binding]; other site 930781007023 cystathionine gamma-synthase; Reviewed; Region: PRK08247 930781007024 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930781007025 homodimer interface [polypeptide binding]; other site 930781007026 substrate-cofactor binding pocket; other site 930781007027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007028 catalytic residue [active] 930781007029 cystathionine beta-lyase; Provisional; Region: PRK08064 930781007030 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930781007031 homodimer interface [polypeptide binding]; other site 930781007032 substrate-cofactor binding pocket; other site 930781007033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007034 catalytic residue [active] 930781007035 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 930781007036 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 930781007037 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 930781007038 FAD binding site [chemical binding]; other site 930781007039 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 930781007040 UbiA prenyltransferase family; Region: UbiA; pfam01040 930781007041 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 930781007042 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930781007043 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 930781007044 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 930781007045 dimer interface [polypeptide binding]; other site 930781007046 tetramer interface [polypeptide binding]; other site 930781007047 PYR/PP interface [polypeptide binding]; other site 930781007048 TPP binding site [chemical binding]; other site 930781007049 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 930781007050 TPP-binding site; other site 930781007051 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781007052 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 930781007053 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930781007054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930781007055 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 930781007056 substrate binding site [chemical binding]; other site 930781007057 oxyanion hole (OAH) forming residues; other site 930781007058 trimer interface [polypeptide binding]; other site 930781007059 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 930781007060 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 930781007061 acyl-activating enzyme (AAE) consensus motif; other site 930781007062 putative AMP binding site [chemical binding]; other site 930781007063 putative active site [active] 930781007064 putative CoA binding site [chemical binding]; other site 930781007065 Uncharacterized conserved protein [Function unknown]; Region: COG0759 930781007066 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 930781007067 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 930781007068 nudix motif; other site 930781007069 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 930781007070 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930781007071 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781007072 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 930781007073 NAD binding site [chemical binding]; other site 930781007074 dimer interface [polypeptide binding]; other site 930781007075 substrate binding site [chemical binding]; other site 930781007076 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 930781007077 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 930781007078 S-adenosylmethionine synthetase; Validated; Region: PRK05250 930781007079 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 930781007080 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 930781007081 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 930781007082 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 930781007083 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930781007084 active site 930781007085 dimer interface [polypeptide binding]; other site 930781007086 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930781007087 Ligand Binding Site [chemical binding]; other site 930781007088 Molecular Tunnel; other site 930781007089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007090 S-adenosylmethionine binding site [chemical binding]; other site 930781007091 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 930781007092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930781007093 FeS/SAM binding site; other site 930781007094 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930781007095 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930781007096 putative active site [active] 930781007097 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 930781007098 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 930781007099 putative active site [active] 930781007100 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930781007101 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 930781007102 active site turn [active] 930781007103 phosphorylation site [posttranslational modification] 930781007104 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930781007105 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 930781007106 rRNA interaction site [nucleotide binding]; other site 930781007107 S8 interaction site; other site 930781007108 putative laminin-1 binding site; other site 930781007109 elongation factor Ts; Provisional; Region: tsf; PRK09377 930781007110 UBA/TS-N domain; Region: UBA; pfam00627 930781007111 Elongation factor TS; Region: EF_TS; pfam00889 930781007112 Elongation factor TS; Region: EF_TS; pfam00889 930781007113 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930781007114 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930781007115 active site 930781007116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781007117 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781007118 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930781007119 Walker A/P-loop; other site 930781007120 ATP binding site [chemical binding]; other site 930781007121 Q-loop/lid; other site 930781007122 ABC transporter signature motif; other site 930781007123 Walker B; other site 930781007124 D-loop; other site 930781007125 H-loop/switch region; other site 930781007126 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 930781007127 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930781007128 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930781007129 putative acyl-acceptor binding pocket; other site 930781007130 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930781007131 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930781007132 active site 930781007133 metal binding site [ion binding]; metal-binding site 930781007134 DNA binding site [nucleotide binding] 930781007135 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 930781007136 Heat induced stress protein YflT; Region: YflT; pfam11181 930781007137 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930781007138 aconitate hydratase; Validated; Region: PRK09277 930781007139 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 930781007140 substrate binding site [chemical binding]; other site 930781007141 ligand binding site [chemical binding]; other site 930781007142 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 930781007143 substrate binding site [chemical binding]; other site 930781007144 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 930781007145 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930781007146 putative dimer interface [polypeptide binding]; other site 930781007147 catalytic triad [active] 930781007148 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930781007149 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 930781007150 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930781007151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781007152 Walker A/P-loop; other site 930781007153 ATP binding site [chemical binding]; other site 930781007154 Q-loop/lid; other site 930781007155 ABC transporter signature motif; other site 930781007156 Walker B; other site 930781007157 D-loop; other site 930781007158 H-loop/switch region; other site 930781007159 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930781007160 dimer interface [polypeptide binding]; other site 930781007161 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 930781007162 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 930781007163 putative catalytic cysteine [active] 930781007164 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 930781007165 putative active site [active] 930781007166 metal binding site [ion binding]; metal-binding site 930781007167 anthranilate synthase component I; Provisional; Region: PRK13570 930781007168 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930781007169 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930781007170 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930781007171 Glutamine amidotransferase class-I; Region: GATase; pfam00117 930781007172 glutamine binding [chemical binding]; other site 930781007173 catalytic triad [active] 930781007174 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 930781007175 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930781007176 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930781007177 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 930781007178 active site 930781007179 ribulose/triose binding site [chemical binding]; other site 930781007180 phosphate binding site [ion binding]; other site 930781007181 substrate (anthranilate) binding pocket [chemical binding]; other site 930781007182 product (indole) binding pocket [chemical binding]; other site 930781007183 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 930781007184 active site 930781007185 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 930781007186 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 930781007187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007188 catalytic residue [active] 930781007189 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 930781007190 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 930781007191 substrate binding site [chemical binding]; other site 930781007192 active site 930781007193 catalytic residues [active] 930781007194 heterodimer interface [polypeptide binding]; other site 930781007195 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930781007196 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930781007197 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930781007198 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930781007199 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930781007200 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930781007201 active site 930781007202 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 930781007203 putative substrate binding site [chemical binding]; other site 930781007204 putative ATP binding site [chemical binding]; other site 930781007205 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 930781007206 nudix motif; other site 930781007207 dipeptidase PepV; Reviewed; Region: PRK07318 930781007208 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 930781007209 active site 930781007210 metal binding site [ion binding]; metal-binding site 930781007211 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930781007212 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930781007213 homodimer interface [polypeptide binding]; other site 930781007214 substrate-cofactor binding pocket; other site 930781007215 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007216 catalytic residue [active] 930781007217 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930781007218 MarR family; Region: MarR; pfam01047 930781007219 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930781007220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781007221 putative substrate translocation pore; other site 930781007222 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781007223 Phosphotransferase enzyme family; Region: APH; pfam01636 930781007224 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930781007225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007226 S-adenosylmethionine binding site [chemical binding]; other site 930781007227 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781007228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 930781007229 putative homodimer interface [polypeptide binding]; other site 930781007230 putative homotetramer interface [polypeptide binding]; other site 930781007231 putative allosteric switch controlling residues; other site 930781007232 putative metal binding site [ion binding]; other site 930781007233 putative homodimer-homodimer interface [polypeptide binding]; other site 930781007234 Predicted small secreted protein [Function unknown]; Region: COG5584 930781007235 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930781007236 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930781007237 oligomer interface [polypeptide binding]; other site 930781007238 active site 930781007239 metal binding site [ion binding]; metal-binding site 930781007240 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 930781007241 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781007242 catalytic residues [active] 930781007243 hypothetical protein; Provisional; Region: PRK13668 930781007244 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930781007245 putative tRNA-binding site [nucleotide binding]; other site 930781007246 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930781007247 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930781007248 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930781007249 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 930781007250 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930781007251 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930781007252 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930781007253 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930781007254 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 930781007255 dimer interface [polypeptide binding]; other site 930781007256 decamer (pentamer of dimers) interface [polypeptide binding]; other site 930781007257 catalytic triad [active] 930781007258 peroxidatic and resolving cysteines [active] 930781007259 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930781007260 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930781007261 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 930781007262 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 930781007263 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 930781007264 Chorismate mutase type II; Region: CM_2; cl00693 930781007265 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 930781007266 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 930781007267 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 930781007268 active site 930781007269 HIGH motif; other site 930781007270 dimer interface [polypeptide binding]; other site 930781007271 KMSKS motif; other site 930781007272 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781007273 RNA binding surface [nucleotide binding]; other site 930781007274 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 930781007275 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 930781007276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781007277 RNA binding surface [nucleotide binding]; other site 930781007278 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 930781007279 GAF domain; Region: GAF_2; pfam13185 930781007280 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 930781007281 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930781007282 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930781007283 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781007284 catalytic residue [active] 930781007285 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 930781007286 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 930781007287 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 930781007288 Ligand Binding Site [chemical binding]; other site 930781007289 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 930781007290 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930781007291 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 930781007292 heterotetramer interface [polypeptide binding]; other site 930781007293 active site pocket [active] 930781007294 cleavage site 930781007295 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 930781007296 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930781007297 inhibitor-cofactor binding pocket; inhibition site 930781007298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007299 catalytic residue [active] 930781007300 ornithine carbamoyltransferase; Provisional; Region: PRK00779 930781007301 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930781007302 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930781007303 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 930781007304 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930781007305 RDD family; Region: RDD; pfam06271 930781007306 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 930781007307 dimer interface [polypeptide binding]; other site 930781007308 catalytic triad [active] 930781007309 peroxidatic and resolving cysteines [active] 930781007310 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 930781007311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007312 S-adenosylmethionine binding site [chemical binding]; other site 930781007313 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930781007314 propionate/acetate kinase; Provisional; Region: PRK12379 930781007315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930781007316 Ligand Binding Site [chemical binding]; other site 930781007317 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930781007318 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 930781007319 hexamer interface [polypeptide binding]; other site 930781007320 ligand binding site [chemical binding]; other site 930781007321 putative active site [active] 930781007322 NAD(P) binding site [chemical binding]; other site 930781007323 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930781007324 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930781007325 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930781007326 active site 930781007327 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930781007328 metal-dependent hydrolase; Provisional; Region: PRK00685 930781007329 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 930781007330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 930781007331 DNA-binding site [nucleotide binding]; DNA binding site 930781007332 DRTGG domain; Region: DRTGG; pfam07085 930781007333 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 930781007334 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 930781007335 active site 2 [active] 930781007336 active site 1 [active] 930781007337 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 930781007338 DHH family; Region: DHH; pfam01368 930781007339 DHHA1 domain; Region: DHHA1; pfam02272 930781007340 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 930781007341 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 930781007342 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 930781007343 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 930781007344 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 930781007345 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 930781007346 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 930781007347 active site 930781007348 ADP/pyrophosphate binding site [chemical binding]; other site 930781007349 dimerization interface [polypeptide binding]; other site 930781007350 allosteric effector site; other site 930781007351 fructose-1,6-bisphosphate binding site; other site 930781007352 pyruvate kinase; Provisional; Region: PRK06354 930781007353 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 930781007354 domain interfaces; other site 930781007355 active site 930781007356 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 930781007357 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 930781007358 Protein of unknown function (DUF441); Region: DUF441; pfam04284 930781007359 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 930781007360 dimer interface [polypeptide binding]; other site 930781007361 Citrate synthase; Region: Citrate_synt; pfam00285 930781007362 active site 930781007363 citrylCoA binding site [chemical binding]; other site 930781007364 oxalacetate/citrate binding site [chemical binding]; other site 930781007365 coenzyme A binding site [chemical binding]; other site 930781007366 catalytic triad [active] 930781007367 isocitrate dehydrogenase; Reviewed; Region: PRK07006 930781007368 isocitrate dehydrogenase; Validated; Region: PRK07362 930781007369 DNA polymerase I; Provisional; Region: PRK05755 930781007370 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930781007371 active site 930781007372 metal binding site 1 [ion binding]; metal-binding site 930781007373 putative 5' ssDNA interaction site; other site 930781007374 metal binding site 3; metal-binding site 930781007375 metal binding site 2 [ion binding]; metal-binding site 930781007376 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930781007377 putative DNA binding site [nucleotide binding]; other site 930781007378 putative metal binding site [ion binding]; other site 930781007379 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 930781007380 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 930781007381 active site 930781007382 DNA binding site [nucleotide binding] 930781007383 catalytic site [active] 930781007384 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 930781007385 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 930781007386 DNA binding site [nucleotide binding] 930781007387 catalytic residue [active] 930781007388 H2TH interface [polypeptide binding]; other site 930781007389 putative catalytic residues [active] 930781007390 turnover-facilitating residue; other site 930781007391 intercalation triad [nucleotide binding]; other site 930781007392 8OG recognition residue [nucleotide binding]; other site 930781007393 putative reading head residues; other site 930781007394 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930781007395 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930781007396 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 930781007397 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 930781007398 CoA-binding site [chemical binding]; other site 930781007399 ATP-binding [chemical binding]; other site 930781007400 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 930781007401 ATP cone domain; Region: ATP-cone; pfam03477 930781007402 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 930781007403 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930781007404 primosomal protein DnaI; Reviewed; Region: PRK08939 930781007405 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 930781007406 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 930781007407 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 930781007408 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930781007409 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 930781007410 active site 930781007411 dimer interface [polypeptide binding]; other site 930781007412 motif 1; other site 930781007413 motif 2; other site 930781007414 motif 3; other site 930781007415 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 930781007416 anticodon binding site; other site 930781007417 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 930781007418 G1 box; other site 930781007419 GTP/Mg2+ binding site [chemical binding]; other site 930781007420 Switch I region; other site 930781007421 G2 box; other site 930781007422 G3 box; other site 930781007423 Switch II region; other site 930781007424 G4 box; other site 930781007425 G5 box; other site 930781007426 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 930781007427 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 930781007428 tRNA; other site 930781007429 putative tRNA binding site [nucleotide binding]; other site 930781007430 putative NADP binding site [chemical binding]; other site 930781007431 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 930781007432 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 930781007433 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 930781007434 domain interfaces; other site 930781007435 active site 930781007436 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 930781007437 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930781007438 active site 930781007439 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 930781007440 dimer interface [polypeptide binding]; other site 930781007441 active site 930781007442 Schiff base residues; other site 930781007443 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 930781007444 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930781007445 inhibitor-cofactor binding pocket; inhibition site 930781007446 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781007447 catalytic residue [active] 930781007448 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 930781007449 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930781007450 active site 930781007451 HIGH motif; other site 930781007452 nucleotide binding site [chemical binding]; other site 930781007453 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930781007454 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 930781007455 active site 930781007456 KMSKS motif; other site 930781007457 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 930781007458 tRNA binding surface [nucleotide binding]; other site 930781007459 anticodon binding site; other site 930781007460 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 930781007461 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 930781007462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930781007463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930781007464 hypothetical protein; Reviewed; Region: PRK00024 930781007465 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 930781007466 MPN+ (JAMM) motif; other site 930781007467 Zinc-binding site [ion binding]; other site 930781007468 rod shape-determining protein MreB; Provisional; Region: PRK13927 930781007469 MreB and similar proteins; Region: MreB_like; cd10225 930781007470 nucleotide binding site [chemical binding]; other site 930781007471 Mg binding site [ion binding]; other site 930781007472 putative protofilament interaction site [polypeptide binding]; other site 930781007473 RodZ interaction site [polypeptide binding]; other site 930781007474 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 930781007475 Protein of unknown function (DUF972); Region: DUF972; pfam06156 930781007476 rod shape-determining protein MreC; Region: MreC; pfam04085 930781007477 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 930781007478 septum formation inhibitor; Reviewed; Region: minC; PRK00513 930781007479 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 930781007480 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 930781007481 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 930781007482 Switch I; other site 930781007483 Switch II; other site 930781007484 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 930781007485 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 930781007486 homodimer interface [polypeptide binding]; other site 930781007487 oligonucleotide binding site [chemical binding]; other site 930781007488 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 930781007489 hypothetical protein; Provisional; Region: PRK14553 930781007490 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 930781007491 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 930781007492 amphipathic channel; other site 930781007493 Asn-Pro-Ala signature motifs; other site 930781007494 glycerol kinase; Provisional; Region: glpK; PRK00047 930781007495 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 930781007496 N- and C-terminal domain interface [polypeptide binding]; other site 930781007497 active site 930781007498 MgATP binding site [chemical binding]; other site 930781007499 catalytic site [active] 930781007500 metal binding site [ion binding]; metal-binding site 930781007501 glycerol binding site [chemical binding]; other site 930781007502 homotetramer interface [polypeptide binding]; other site 930781007503 homodimer interface [polypeptide binding]; other site 930781007504 FBP binding site [chemical binding]; other site 930781007505 protein IIAGlc interface [polypeptide binding]; other site 930781007506 GTPase CgtA; Reviewed; Region: obgE; PRK12297 930781007507 GTP1/OBG; Region: GTP1_OBG; pfam01018 930781007508 Obg GTPase; Region: Obg; cd01898 930781007509 G1 box; other site 930781007510 GTP/Mg2+ binding site [chemical binding]; other site 930781007511 Switch I region; other site 930781007512 G2 box; other site 930781007513 G3 box; other site 930781007514 Switch II region; other site 930781007515 G4 box; other site 930781007516 G5 box; other site 930781007517 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 930781007518 prephenate dehydratase; Provisional; Region: PRK11898 930781007519 Prephenate dehydratase; Region: PDT; pfam00800 930781007520 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 930781007521 putative L-Phe binding site [chemical binding]; other site 930781007522 hypothetical protein; Validated; Region: PRK00110 930781007523 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930781007524 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930781007525 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 930781007526 NAD binding site [chemical binding]; other site 930781007527 dimer interface [polypeptide binding]; other site 930781007528 substrate binding site [chemical binding]; other site 930781007529 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 930781007530 RuvA N terminal domain; Region: RuvA_N; pfam01330 930781007531 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 930781007532 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 930781007533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781007534 Walker A motif; other site 930781007535 ATP binding site [chemical binding]; other site 930781007536 Walker B motif; other site 930781007537 arginine finger; other site 930781007538 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 930781007539 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 930781007540 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 930781007541 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 930781007542 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 930781007543 Preprotein translocase subunit; Region: YajC; pfam02699 930781007544 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 930781007545 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 930781007546 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 930781007547 Protein export membrane protein; Region: SecD_SecF; cl14618 930781007548 Protein export membrane protein; Region: SecD_SecF; pfam02355 930781007549 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 930781007550 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 930781007551 DHH family; Region: DHH; pfam01368 930781007552 DHHA1 domain; Region: DHHA1; pfam02272 930781007553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 930781007554 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930781007555 active site 930781007556 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930781007557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781007558 Zn2+ binding site [ion binding]; other site 930781007559 Mg2+ binding site [ion binding]; other site 930781007560 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930781007561 synthetase active site [active] 930781007562 NTP binding site [chemical binding]; other site 930781007563 metal binding site [ion binding]; metal-binding site 930781007564 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 930781007565 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 930781007566 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 930781007567 putative active site [active] 930781007568 dimerization interface [polypeptide binding]; other site 930781007569 putative tRNAtyr binding site [nucleotide binding]; other site 930781007570 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 930781007571 Bacterial SH3 domain; Region: SH3_3; pfam08239 930781007572 Bacterial SH3 domain; Region: SH3_3; pfam08239 930781007573 Bacterial SH3 domain homologues; Region: SH3b; smart00287 930781007574 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930781007575 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930781007576 active site 930781007577 metal binding site [ion binding]; metal-binding site 930781007578 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 930781007579 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 930781007580 dimer interface [polypeptide binding]; other site 930781007581 anticodon binding site; other site 930781007582 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930781007583 homodimer interface [polypeptide binding]; other site 930781007584 motif 1; other site 930781007585 active site 930781007586 motif 2; other site 930781007587 GAD domain; Region: GAD; pfam02938 930781007588 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930781007589 motif 3; other site 930781007590 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 930781007591 Nitrogen regulatory protein P-II; Region: P-II; smart00938 930781007592 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930781007593 Predicted transcriptional regulator [Transcription]; Region: COG1959 930781007594 Transcriptional regulator; Region: Rrf2; pfam02082 930781007595 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 930781007596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781007597 Walker A motif; other site 930781007598 ATP binding site [chemical binding]; other site 930781007599 Walker B motif; other site 930781007600 arginine finger; other site 930781007601 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 930781007602 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930781007603 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930781007604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930781007605 catalytic residue [active] 930781007606 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 930781007607 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 930781007608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781007609 binding surface 930781007610 TPR motif; other site 930781007611 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 930781007612 TPR repeat; Region: TPR_11; pfam13414 930781007613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781007614 binding surface 930781007615 TPR motif; other site 930781007616 TPR repeat; Region: TPR_11; pfam13414 930781007617 sensor kinase CusS; Provisional; Region: PRK09835 930781007618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930781007619 dimerization interface [polypeptide binding]; other site 930781007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781007621 dimer interface [polypeptide binding]; other site 930781007622 phosphorylation site [posttranslational modification] 930781007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781007624 ATP binding site [chemical binding]; other site 930781007625 Mg2+ binding site [ion binding]; other site 930781007626 G-X-G motif; other site 930781007627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781007629 active site 930781007630 phosphorylation site [posttranslational modification] 930781007631 intermolecular recognition site; other site 930781007632 dimerization interface [polypeptide binding]; other site 930781007633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781007634 DNA binding site [nucleotide binding] 930781007635 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781007636 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930781007637 FtsX-like permease family; Region: FtsX; pfam02687 930781007638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781007639 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781007640 Walker A/P-loop; other site 930781007641 ATP binding site [chemical binding]; other site 930781007642 Q-loop/lid; other site 930781007643 ABC transporter signature motif; other site 930781007644 Walker B; other site 930781007645 D-loop; other site 930781007646 H-loop/switch region; other site 930781007647 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 930781007648 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 930781007649 motif 1; other site 930781007650 active site 930781007651 motif 2; other site 930781007652 motif 3; other site 930781007653 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930781007654 DHHA1 domain; Region: DHHA1; pfam02272 930781007655 hypothetical protein; Provisional; Region: PRK05473 930781007656 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 930781007657 hypothetical protein; Provisional; Region: PRK13678 930781007658 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930781007659 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930781007660 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 930781007661 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 930781007662 dimerization interface [polypeptide binding]; other site 930781007663 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 930781007664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007665 S-adenosylmethionine binding site [chemical binding]; other site 930781007666 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 930781007667 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 930781007668 Sugar specificity; other site 930781007669 Pyrimidine base specificity; other site 930781007670 ATP-binding site [chemical binding]; other site 930781007671 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 930781007672 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 930781007673 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 930781007674 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 930781007675 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 930781007676 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 930781007677 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 930781007678 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 930781007679 active site 930781007680 Zn binding site [ion binding]; other site 930781007681 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 930781007682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930781007683 motif II; other site 930781007684 GTPase YqeH; Provisional; Region: PRK13796 930781007685 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 930781007686 GTP/Mg2+ binding site [chemical binding]; other site 930781007687 G4 box; other site 930781007688 G5 box; other site 930781007689 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930781007690 G1 box; other site 930781007691 G1 box; other site 930781007692 GTP/Mg2+ binding site [chemical binding]; other site 930781007693 G2 box; other site 930781007694 Switch I region; other site 930781007695 G2 box; other site 930781007696 Switch I region; other site 930781007697 G3 box; other site 930781007698 G3 box; other site 930781007699 Switch II region; other site 930781007700 Switch II region; other site 930781007701 G4 box; other site 930781007702 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 930781007703 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930781007704 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930781007705 shikimate binding site; other site 930781007706 NAD(P) binding site [chemical binding]; other site 930781007707 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 930781007708 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 930781007709 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 930781007710 active site 930781007711 (T/H)XGH motif; other site 930781007712 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781007713 Zn2+ binding site [ion binding]; other site 930781007714 Mg2+ binding site [ion binding]; other site 930781007715 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 930781007716 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930781007717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007718 S-adenosylmethionine binding site [chemical binding]; other site 930781007719 SLBB domain; Region: SLBB; pfam10531 930781007720 comEA protein; Region: comE; TIGR01259 930781007721 Helix-hairpin-helix motif; Region: HHH; pfam00633 930781007722 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 930781007723 catalytic motif [active] 930781007724 Zn binding site [ion binding]; other site 930781007725 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 930781007726 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 930781007727 Competence protein; Region: Competence; pfam03772 930781007728 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781007729 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 930781007730 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 930781007731 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 930781007732 GTP-binding protein LepA; Provisional; Region: PRK05433 930781007733 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 930781007734 G1 box; other site 930781007735 putative GEF interaction site [polypeptide binding]; other site 930781007736 GTP/Mg2+ binding site [chemical binding]; other site 930781007737 Switch I region; other site 930781007738 G2 box; other site 930781007739 G3 box; other site 930781007740 Switch II region; other site 930781007741 G4 box; other site 930781007742 G5 box; other site 930781007743 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 930781007744 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 930781007745 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 930781007746 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930781007747 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781007748 DNA binding residues [nucleotide binding] 930781007749 putative dimer interface [polypeptide binding]; other site 930781007750 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930781007751 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 930781007752 NADP binding site [chemical binding]; other site 930781007753 putative substrate binding site [chemical binding]; other site 930781007754 active site 930781007755 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 930781007756 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930781007757 FeS/SAM binding site; other site 930781007758 HemN C-terminal domain; Region: HemN_C; pfam06969 930781007759 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 930781007760 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 930781007761 heat shock protein GrpE; Provisional; Region: PRK14140 930781007762 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 930781007763 dimer interface [polypeptide binding]; other site 930781007764 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 930781007765 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 930781007766 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 930781007767 nucleotide binding site [chemical binding]; other site 930781007768 NEF interaction site [polypeptide binding]; other site 930781007769 SBD interface [polypeptide binding]; other site 930781007770 chaperone protein DnaJ; Provisional; Region: PRK14280 930781007771 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930781007772 HSP70 interaction site [polypeptide binding]; other site 930781007773 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 930781007774 substrate binding site [polypeptide binding]; other site 930781007775 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 930781007776 Zn binding sites [ion binding]; other site 930781007777 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 930781007778 dimer interface [polypeptide binding]; other site 930781007779 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 930781007780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781007781 S-adenosylmethionine binding site [chemical binding]; other site 930781007782 RNA methyltransferase, RsmE family; Region: TIGR00046 930781007783 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 930781007784 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 930781007785 Yqey-like protein; Region: YqeY; pfam09424 930781007786 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 930781007787 PhoH-like protein; Region: PhoH; pfam02562 930781007788 metal-binding heat shock protein; Provisional; Region: PRK00016 930781007789 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 930781007790 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930781007791 active site 930781007792 catalytic motif [active] 930781007793 Zn binding site [ion binding]; other site 930781007794 GTPase Era; Reviewed; Region: era; PRK00089 930781007795 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 930781007796 G1 box; other site 930781007797 GTP/Mg2+ binding site [chemical binding]; other site 930781007798 Switch I region; other site 930781007799 G2 box; other site 930781007800 Switch II region; other site 930781007801 G3 box; other site 930781007802 G4 box; other site 930781007803 G5 box; other site 930781007804 KH domain; Region: KH_2; pfam07650 930781007805 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 930781007806 DNA repair protein RecO; Region: reco; TIGR00613 930781007807 Recombination protein O N terminal; Region: RecO_N; pfam11967 930781007808 Recombination protein O C terminal; Region: RecO_C; pfam02565 930781007809 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 930781007810 dimer interface [polypeptide binding]; other site 930781007811 motif 1; other site 930781007812 active site 930781007813 motif 2; other site 930781007814 motif 3; other site 930781007815 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 930781007816 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 930781007817 DALR anticodon binding domain; Region: DALR_1; pfam05746 930781007818 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 930781007819 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 930781007820 DNA primase; Validated; Region: dnaG; PRK05667 930781007821 CHC2 zinc finger; Region: zf-CHC2; pfam01807 930781007822 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 930781007823 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 930781007824 active site 930781007825 metal binding site [ion binding]; metal-binding site 930781007826 interdomain interaction site; other site 930781007827 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 930781007828 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 930781007829 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 930781007830 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 930781007831 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930781007832 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930781007833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930781007834 DNA binding residues [nucleotide binding] 930781007835 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 930781007836 Family of unknown function (DUF633); Region: DUF633; pfam04816 930781007837 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930781007838 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930781007839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930781007840 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930781007841 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930781007842 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 930781007843 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 930781007844 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930781007845 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930781007846 ATP binding site [chemical binding]; other site 930781007847 Mg++ binding site [ion binding]; other site 930781007848 motif III; other site 930781007849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781007850 nucleotide binding region [chemical binding]; other site 930781007851 ATP-binding site [chemical binding]; other site 930781007852 endonuclease IV; Provisional; Region: PRK01060 930781007853 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 930781007854 AP (apurinic/apyrimidinic) site pocket; other site 930781007855 DNA interaction; other site 930781007856 Metal-binding active site; metal-binding site 930781007857 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 930781007858 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 930781007859 DHHA2 domain; Region: DHHA2; pfam02833 930781007860 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930781007861 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930781007862 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930781007863 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930781007864 ABC-ATPase subunit interface; other site 930781007865 dimer interface [polypeptide binding]; other site 930781007866 putative PBP binding regions; other site 930781007867 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930781007868 metal binding site 2 [ion binding]; metal-binding site 930781007869 putative DNA binding helix; other site 930781007870 metal binding site 1 [ion binding]; metal-binding site 930781007871 dimer interface [polypeptide binding]; other site 930781007872 structural Zn2+ binding site [ion binding]; other site 930781007873 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 930781007874 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930781007875 Predicted membrane protein [Function unknown]; Region: COG4392 930781007876 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 930781007877 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 930781007878 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930781007879 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930781007880 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 930781007881 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930781007882 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930781007883 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930781007884 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930781007885 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930781007886 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930781007887 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 930781007888 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930781007889 aspartate kinase I; Reviewed; Region: PRK08210 930781007890 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 930781007891 nucleotide binding site [chemical binding]; other site 930781007892 substrate binding site [chemical binding]; other site 930781007893 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 930781007894 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 930781007895 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 930781007896 dihydrodipicolinate synthase; Region: dapA; TIGR00674 930781007897 dimer interface [polypeptide binding]; other site 930781007898 active site 930781007899 catalytic residue [active] 930781007900 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930781007901 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930781007902 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930781007903 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 930781007904 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930781007905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781007906 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930781007907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 930781007908 Predicted membrane protein [Function unknown]; Region: COG3859 930781007909 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930781007910 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 930781007911 Walker A/P-loop; other site 930781007912 ATP binding site [chemical binding]; other site 930781007913 Q-loop/lid; other site 930781007914 ABC transporter signature motif; other site 930781007915 Walker B; other site 930781007916 D-loop; other site 930781007917 H-loop/switch region; other site 930781007918 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 930781007919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781007920 dimer interface [polypeptide binding]; other site 930781007921 conserved gate region; other site 930781007922 putative PBP binding loops; other site 930781007923 ABC-ATPase subunit interface; other site 930781007924 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930781007925 LysR substrate binding domain; Region: LysR_substrate; pfam03466 930781007926 dimerization interface [polypeptide binding]; other site 930781007927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781007928 dimer interface [polypeptide binding]; other site 930781007929 conserved gate region; other site 930781007930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930781007931 ABC-ATPase subunit interface; other site 930781007932 manganese transport protein MntH; Reviewed; Region: PRK00701 930781007933 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930781007934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930781007935 dimer interface [polypeptide binding]; other site 930781007936 conserved gate region; other site 930781007937 ABC-ATPase subunit interface; other site 930781007938 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 930781007939 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 930781007940 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 930781007941 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930781007942 Walker A/P-loop; other site 930781007943 ATP binding site [chemical binding]; other site 930781007944 Q-loop/lid; other site 930781007945 ABC transporter signature motif; other site 930781007946 Walker B; other site 930781007947 D-loop; other site 930781007948 H-loop/switch region; other site 930781007949 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 930781007950 FAD binding domain; Region: FAD_binding_4; pfam01565 930781007951 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 930781007952 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930781007953 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930781007954 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 930781007955 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 930781007956 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 930781007957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781007958 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930781007959 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 930781007960 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 930781007961 dimer interface [polypeptide binding]; other site 930781007962 active site 930781007963 putative acyltransferase; Provisional; Region: PRK05790 930781007964 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930781007965 dimer interface [polypeptide binding]; other site 930781007966 active site 930781007967 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781007968 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781007969 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930781007970 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781007971 topology modulation protein; Reviewed; Region: PRK08118 930781007972 AAA domain; Region: AAA_17; pfam13207 930781007973 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781007974 non-specific DNA binding site [nucleotide binding]; other site 930781007975 salt bridge; other site 930781007976 sequence-specific DNA binding site [nucleotide binding]; other site 930781007977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781007978 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781007979 putative substrate translocation pore; other site 930781007980 Predicted transcriptional regulators [Transcription]; Region: COG1695 930781007981 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930781007982 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 930781007983 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 930781007984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930781007985 FeS/SAM binding site; other site 930781007986 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 930781007987 Pyruvate formate lyase 1; Region: PFL1; cd01678 930781007988 coenzyme A binding site [chemical binding]; other site 930781007989 active site 930781007990 catalytic residues [active] 930781007991 glycine loop; other site 930781007992 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 930781007993 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 930781007994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781007995 ATP binding site [chemical binding]; other site 930781007996 Mg2+ binding site [ion binding]; other site 930781007997 G-X-G motif; other site 930781007998 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 930781007999 ATP binding site [chemical binding]; other site 930781008000 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 930781008001 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 930781008002 MutS domain I; Region: MutS_I; pfam01624 930781008003 MutS domain II; Region: MutS_II; pfam05188 930781008004 MutS domain III; Region: MutS_III; pfam05192 930781008005 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 930781008006 Walker A/P-loop; other site 930781008007 ATP binding site [chemical binding]; other site 930781008008 Q-loop/lid; other site 930781008009 ABC transporter signature motif; other site 930781008010 Walker B; other site 930781008011 D-loop; other site 930781008012 H-loop/switch region; other site 930781008013 Predicted membrane protein [Function unknown]; Region: COG4550 930781008014 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 930781008015 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930781008016 putative active site [active] 930781008017 metal binding site [ion binding]; metal-binding site 930781008018 homodimer binding site [polypeptide binding]; other site 930781008019 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930781008020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781008021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930781008022 Coenzyme A binding pocket [chemical binding]; other site 930781008023 phosphodiesterase; Provisional; Region: PRK12704 930781008024 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930781008025 Zn2+ binding site [ion binding]; other site 930781008026 Mg2+ binding site [ion binding]; other site 930781008027 recombinase A; Provisional; Region: recA; PRK09354 930781008028 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 930781008029 hexamer interface [polypeptide binding]; other site 930781008030 Walker A motif; other site 930781008031 ATP binding site [chemical binding]; other site 930781008032 Walker B motif; other site 930781008033 competence damage-inducible protein A; Provisional; Region: PRK00549 930781008034 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 930781008035 putative MPT binding site; other site 930781008036 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 930781008037 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 930781008038 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 930781008039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781008040 non-specific DNA binding site [nucleotide binding]; other site 930781008041 salt bridge; other site 930781008042 sequence-specific DNA binding site [nucleotide binding]; other site 930781008043 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 930781008044 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930781008045 classical (c) SDRs; Region: SDR_c; cd05233 930781008046 NAD(P) binding site [chemical binding]; other site 930781008047 active site 930781008048 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930781008049 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 930781008050 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930781008051 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930781008052 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930781008053 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930781008054 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930781008055 TM-ABC transporter signature motif; other site 930781008056 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930781008057 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930781008058 TM-ABC transporter signature motif; other site 930781008059 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 930781008060 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930781008061 Walker A/P-loop; other site 930781008062 ATP binding site [chemical binding]; other site 930781008063 Q-loop/lid; other site 930781008064 ABC transporter signature motif; other site 930781008065 Walker B; other site 930781008066 D-loop; other site 930781008067 H-loop/switch region; other site 930781008068 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930781008069 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 930781008070 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 930781008071 ligand binding site [chemical binding]; other site 930781008072 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 930781008073 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 930781008074 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 930781008075 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930781008076 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930781008077 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930781008078 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930781008079 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781008080 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781008081 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 930781008082 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 930781008083 active site residue [active] 930781008084 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 930781008085 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 930781008086 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 930781008087 homotetramer interface [polypeptide binding]; other site 930781008088 FMN binding site [chemical binding]; other site 930781008089 homodimer contacts [polypeptide binding]; other site 930781008090 putative active site [active] 930781008091 putative substrate binding site [chemical binding]; other site 930781008092 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 930781008093 acylphosphatase; Provisional; Region: PRK14443 930781008094 OxaA-like protein precursor; Validated; Region: PRK01622 930781008095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930781008096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930781008097 dimerization interface [polypeptide binding]; other site 930781008098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930781008099 dimer interface [polypeptide binding]; other site 930781008100 phosphorylation site [posttranslational modification] 930781008101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781008102 ATP binding site [chemical binding]; other site 930781008103 Mg2+ binding site [ion binding]; other site 930781008104 G-X-G motif; other site 930781008105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930781008106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781008107 active site 930781008108 phosphorylation site [posttranslational modification] 930781008109 intermolecular recognition site; other site 930781008110 dimerization interface [polypeptide binding]; other site 930781008111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930781008112 DNA binding site [nucleotide binding] 930781008113 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930781008114 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 930781008115 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 930781008116 peptidase T-like protein; Region: PepT-like; TIGR01883 930781008117 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 930781008118 metal binding site [ion binding]; metal-binding site 930781008119 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930781008120 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930781008121 E3 interaction surface; other site 930781008122 lipoyl attachment site [posttranslational modification]; other site 930781008123 e3 binding domain; Region: E3_binding; pfam02817 930781008124 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930781008125 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930781008126 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930781008127 alpha subunit interface [polypeptide binding]; other site 930781008128 TPP binding site [chemical binding]; other site 930781008129 heterodimer interface [polypeptide binding]; other site 930781008130 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781008131 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 930781008132 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930781008133 tetramer interface [polypeptide binding]; other site 930781008134 TPP-binding site [chemical binding]; other site 930781008135 heterodimer interface [polypeptide binding]; other site 930781008136 phosphorylation loop region [posttranslational modification] 930781008137 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 930781008138 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930781008139 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930781008140 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781008141 nucleotide binding site [chemical binding]; other site 930781008142 Acetokinase family; Region: Acetate_kinase; cl17229 930781008143 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 930781008144 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 930781008145 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930781008146 Walker A/P-loop; other site 930781008147 ATP binding site [chemical binding]; other site 930781008148 Q-loop/lid; other site 930781008149 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930781008150 ABC transporter signature motif; other site 930781008151 Walker B; other site 930781008152 D-loop; other site 930781008153 H-loop/switch region; other site 930781008154 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 930781008155 arginine repressor; Provisional; Region: PRK04280 930781008156 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 930781008157 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 930781008158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930781008159 RNA binding surface [nucleotide binding]; other site 930781008160 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 930781008161 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 930781008162 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 930781008163 TPP-binding site; other site 930781008164 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930781008165 PYR/PP interface [polypeptide binding]; other site 930781008166 dimer interface [polypeptide binding]; other site 930781008167 TPP binding site [chemical binding]; other site 930781008168 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781008169 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930781008170 DNA-binding site [nucleotide binding]; DNA binding site 930781008171 RNA-binding motif; other site 930781008172 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930781008173 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930781008174 substrate binding pocket [chemical binding]; other site 930781008175 chain length determination region; other site 930781008176 substrate-Mg2+ binding site; other site 930781008177 catalytic residues [active] 930781008178 aspartate-rich region 1; other site 930781008179 active site lid residues [active] 930781008180 aspartate-rich region 2; other site 930781008181 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 930781008182 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 930781008183 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 930781008184 generic binding surface II; other site 930781008185 generic binding surface I; other site 930781008186 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 930781008187 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 930781008188 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 930781008189 homodimer interface [polypeptide binding]; other site 930781008190 NADP binding site [chemical binding]; other site 930781008191 substrate binding site [chemical binding]; other site 930781008192 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 930781008193 putative RNA binding site [nucleotide binding]; other site 930781008194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 930781008195 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 930781008196 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930781008197 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930781008198 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930781008199 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 930781008200 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930781008201 carboxyltransferase (CT) interaction site; other site 930781008202 biotinylation site [posttranslational modification]; other site 930781008203 elongation factor P; Validated; Region: PRK00529 930781008204 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 930781008205 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 930781008206 RNA binding site [nucleotide binding]; other site 930781008207 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 930781008208 RNA binding site [nucleotide binding]; other site 930781008209 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930781008210 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930781008211 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930781008212 active site 930781008213 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 930781008214 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930781008215 active site residue [active] 930781008216 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930781008217 tetramer interface [polypeptide binding]; other site 930781008218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781008219 catalytic residue [active] 930781008220 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 930781008221 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930781008222 tetramer interface [polypeptide binding]; other site 930781008223 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781008224 catalytic residue [active] 930781008225 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 930781008226 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 930781008227 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930781008228 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 930781008229 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 930781008230 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 930781008231 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 930781008232 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930781008233 nucleotide binding site [chemical binding]; other site 930781008234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 930781008235 Rhomboid family; Region: Rhomboid; pfam01694 930781008236 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930781008237 TPR motif; other site 930781008238 TPR repeat; Region: TPR_11; pfam13414 930781008239 binding surface 930781008240 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 930781008241 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 930781008242 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 930781008243 YceG-like family; Region: YceG; pfam02618 930781008244 GTPase RsgA; Reviewed; Region: PRK01889 930781008245 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930781008246 RNA binding site [nucleotide binding]; other site 930781008247 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930781008248 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930781008249 GTP/Mg2+ binding site [chemical binding]; other site 930781008250 G4 box; other site 930781008251 G5 box; other site 930781008252 G1 box; other site 930781008253 Switch I region; other site 930781008254 G2 box; other site 930781008255 G3 box; other site 930781008256 Switch II region; other site 930781008257 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 930781008258 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 930781008259 RNase E interface [polypeptide binding]; other site 930781008260 trimer interface [polypeptide binding]; other site 930781008261 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 930781008262 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 930781008263 RNase E interface [polypeptide binding]; other site 930781008264 trimer interface [polypeptide binding]; other site 930781008265 active site 930781008266 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 930781008267 putative nucleic acid binding region [nucleotide binding]; other site 930781008268 G-X-X-G motif; other site 930781008269 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 930781008270 RNA binding site [nucleotide binding]; other site 930781008271 domain interface; other site 930781008272 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 930781008273 16S/18S rRNA binding site [nucleotide binding]; other site 930781008274 S13e-L30e interaction site [polypeptide binding]; other site 930781008275 25S rRNA binding site [nucleotide binding]; other site 930781008276 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 930781008277 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930781008278 active site 930781008279 Riboflavin kinase; Region: Flavokinase; smart00904 930781008280 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 930781008281 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 930781008282 RNA binding site [nucleotide binding]; other site 930781008283 active site 930781008284 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 930781008285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 930781008286 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930781008287 translation initiation factor IF-2; Region: IF-2; TIGR00487 930781008288 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930781008289 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 930781008290 G1 box; other site 930781008291 putative GEF interaction site [polypeptide binding]; other site 930781008292 GTP/Mg2+ binding site [chemical binding]; other site 930781008293 Switch I region; other site 930781008294 G2 box; other site 930781008295 G3 box; other site 930781008296 Switch II region; other site 930781008297 G4 box; other site 930781008298 G5 box; other site 930781008299 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 930781008300 Translation-initiation factor 2; Region: IF-2; pfam11987 930781008301 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 930781008302 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 930781008303 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 930781008304 putative RNA binding cleft [nucleotide binding]; other site 930781008305 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 930781008306 NusA N-terminal domain; Region: NusA_N; pfam08529 930781008307 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 930781008308 RNA binding site [nucleotide binding]; other site 930781008309 homodimer interface [polypeptide binding]; other site 930781008310 NusA-like KH domain; Region: KH_5; pfam13184 930781008311 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 930781008312 G-X-X-G motif; other site 930781008313 ribosome maturation protein RimP; Reviewed; Region: PRK00092 930781008314 Sm and related proteins; Region: Sm_like; cl00259 930781008315 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 930781008316 putative oligomer interface [polypeptide binding]; other site 930781008317 putative RNA binding site [nucleotide binding]; other site 930781008318 prolyl-tRNA synthetase; Provisional; Region: PRK09194 930781008319 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 930781008320 dimer interface [polypeptide binding]; other site 930781008321 motif 1; other site 930781008322 active site 930781008323 motif 2; other site 930781008324 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 930781008325 putative deacylase active site [active] 930781008326 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930781008327 active site 930781008328 motif 3; other site 930781008329 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 930781008330 anticodon binding site; other site 930781008331 RIP metalloprotease RseP; Region: TIGR00054 930781008332 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930781008333 active site 930781008334 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930781008335 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930781008336 protein binding site [polypeptide binding]; other site 930781008337 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930781008338 putative substrate binding region [chemical binding]; other site 930781008339 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 930781008340 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 930781008341 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 930781008342 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 930781008343 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 930781008344 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 930781008345 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 930781008346 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 930781008347 catalytic residue [active] 930781008348 putative FPP diphosphate binding site; other site 930781008349 putative FPP binding hydrophobic cleft; other site 930781008350 dimer interface [polypeptide binding]; other site 930781008351 putative IPP diphosphate binding site; other site 930781008352 ribosome recycling factor; Reviewed; Region: frr; PRK00083 930781008353 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 930781008354 hinge region; other site 930781008355 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 930781008356 putative nucleotide binding site [chemical binding]; other site 930781008357 uridine monophosphate binding site [chemical binding]; other site 930781008358 homohexameric interface [polypeptide binding]; other site 930781008359 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930781008360 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 930781008361 ParB-like nuclease domain; Region: ParBc; pfam02195 930781008362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930781008363 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930781008364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781008365 S-adenosylmethionine binding site [chemical binding]; other site 930781008366 hypothetical protein; Provisional; Region: PRK01844 930781008367 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930781008368 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930781008369 TPP-binding site [chemical binding]; other site 930781008370 dimer interface [polypeptide binding]; other site 930781008371 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930781008372 PYR/PP interface [polypeptide binding]; other site 930781008373 dimer interface [polypeptide binding]; other site 930781008374 TPP binding site [chemical binding]; other site 930781008375 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930781008376 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 930781008377 cell division suppressor protein YneA; Provisional; Region: PRK14125 930781008378 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 930781008379 LexA repressor; Validated; Region: PRK00215 930781008380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781008381 putative DNA binding site [nucleotide binding]; other site 930781008382 putative Zn2+ binding site [ion binding]; other site 930781008383 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 930781008384 Catalytic site [active] 930781008385 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930781008386 arsenical pump membrane protein; Provisional; Region: PRK15445 930781008387 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 930781008388 transmembrane helices; other site 930781008389 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 930781008390 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 930781008391 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 930781008392 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 930781008393 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930781008394 DNA binding residues [nucleotide binding] 930781008395 putative dimer interface [polypeptide binding]; other site 930781008396 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 930781008397 Aluminium resistance protein; Region: Alum_res; pfam06838 930781008398 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 930781008399 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930781008400 HflX GTPase family; Region: HflX; cd01878 930781008401 G1 box; other site 930781008402 GTP/Mg2+ binding site [chemical binding]; other site 930781008403 Switch I region; other site 930781008404 G2 box; other site 930781008405 G3 box; other site 930781008406 Switch II region; other site 930781008407 G4 box; other site 930781008408 G5 box; other site 930781008409 bacterial Hfq-like; Region: Hfq; cd01716 930781008410 hexamer interface [polypeptide binding]; other site 930781008411 Sm1 motif; other site 930781008412 RNA binding site [nucleotide binding]; other site 930781008413 Sm2 motif; other site 930781008414 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 930781008415 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 930781008416 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 930781008417 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930781008418 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 930781008419 active site 930781008420 catalytic site [active] 930781008421 metal binding site [ion binding]; metal-binding site 930781008422 dimer interface [polypeptide binding]; other site 930781008423 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 930781008424 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 930781008425 catalytic triad [active] 930781008426 catalytic triad [active] 930781008427 oxyanion hole [active] 930781008428 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930781008429 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781008430 S-ribosylhomocysteinase; Provisional; Region: PRK02260 930781008431 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 930781008432 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930781008433 CAP-like domain; other site 930781008434 active site 930781008435 primary dimer interface [polypeptide binding]; other site 930781008436 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930781008437 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 930781008438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781008439 Mg2+ binding site [ion binding]; other site 930781008440 G-X-G motif; other site 930781008441 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930781008442 anchoring element; other site 930781008443 dimer interface [polypeptide binding]; other site 930781008444 ATP binding site [chemical binding]; other site 930781008445 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930781008446 active site 930781008447 putative metal-binding site [ion binding]; other site 930781008448 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930781008449 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 930781008450 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 930781008451 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 930781008452 active site 930781008453 catalytic residues [active] 930781008454 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930781008455 active site 930781008456 transcriptional repressor CodY; Validated; Region: PRK04158 930781008457 CodY GAF-like domain; Region: CodY; pfam06018 930781008458 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 930781008459 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 930781008460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781008461 Walker A motif; other site 930781008462 ATP binding site [chemical binding]; other site 930781008463 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 930781008464 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930781008465 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 930781008466 active site 930781008467 HslU subunit interaction site [polypeptide binding]; other site 930781008468 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 930781008469 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930781008470 active site 930781008471 DNA binding site [nucleotide binding] 930781008472 Int/Topo IB signature motif; other site 930781008473 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 930781008474 Glucose inhibited division protein A; Region: GIDA; pfam01134 930781008475 DNA topoisomerase I; Validated; Region: PRK05582 930781008476 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 930781008477 active site 930781008478 interdomain interaction site; other site 930781008479 putative metal-binding site [ion binding]; other site 930781008480 nucleotide binding site [chemical binding]; other site 930781008481 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930781008482 domain I; other site 930781008483 DNA binding groove [nucleotide binding] 930781008484 phosphate binding site [ion binding]; other site 930781008485 domain II; other site 930781008486 domain III; other site 930781008487 nucleotide binding site [chemical binding]; other site 930781008488 catalytic site [active] 930781008489 domain IV; other site 930781008490 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930781008491 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930781008492 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 930781008493 DNA protecting protein DprA; Region: dprA; TIGR00732 930781008494 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 930781008495 RNA/DNA hybrid binding site [nucleotide binding]; other site 930781008496 active site 930781008497 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 930781008498 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 930781008499 GTP/Mg2+ binding site [chemical binding]; other site 930781008500 G4 box; other site 930781008501 G5 box; other site 930781008502 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930781008503 G1 box; other site 930781008504 G1 box; other site 930781008505 GTP/Mg2+ binding site [chemical binding]; other site 930781008506 Switch I region; other site 930781008507 G2 box; other site 930781008508 G2 box; other site 930781008509 G3 box; other site 930781008510 G3 box; other site 930781008511 Switch II region; other site 930781008512 Switch II region; other site 930781008513 G5 box; other site 930781008514 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 930781008515 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930781008516 Catalytic site [active] 930781008517 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930781008518 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930781008519 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930781008520 Catalytic site [active] 930781008521 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930781008522 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930781008523 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930781008524 Catalytic site [active] 930781008525 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930781008526 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 930781008527 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 930781008528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930781008529 Walker A motif; other site 930781008530 ATP binding site [chemical binding]; other site 930781008531 Walker B motif; other site 930781008532 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930781008533 trigger factor; Provisional; Region: tig; PRK01490 930781008534 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930781008535 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 930781008536 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930781008537 active site 930781008538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781008539 non-specific DNA binding site [nucleotide binding]; other site 930781008540 salt bridge; other site 930781008541 sequence-specific DNA binding site [nucleotide binding]; other site 930781008542 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930781008543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930781008544 non-specific DNA binding site [nucleotide binding]; other site 930781008545 salt bridge; other site 930781008546 sequence-specific DNA binding site [nucleotide binding]; other site 930781008547 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 930781008548 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 930781008549 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 930781008550 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 930781008551 nucleotide binding site [chemical binding]; other site 930781008552 homotetrameric interface [polypeptide binding]; other site 930781008553 putative phosphate binding site [ion binding]; other site 930781008554 putative allosteric binding site; other site 930781008555 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 930781008556 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 930781008557 putative catalytic cysteine [active] 930781008558 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930781008559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781008560 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 930781008561 nudix motif; other site 930781008562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930781008563 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 930781008564 active site turn [active] 930781008565 phosphorylation site [posttranslational modification] 930781008566 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930781008567 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930781008568 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930781008569 Ca binding site [ion binding]; other site 930781008570 active site 930781008571 catalytic site [active] 930781008572 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 930781008573 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930781008574 DNA-binding site [nucleotide binding]; DNA binding site 930781008575 UTRA domain; Region: UTRA; pfam07702 930781008576 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930781008577 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930781008578 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930781008579 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930781008580 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930781008581 ligand binding site [chemical binding]; other site 930781008582 flexible hinge region; other site 930781008583 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930781008584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930781008585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930781008586 putative substrate translocation pore; other site 930781008587 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930781008588 putative active site [active] 930781008589 nucleotide binding site [chemical binding]; other site 930781008590 nudix motif; other site 930781008591 putative metal binding site [ion binding]; other site 930781008592 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930781008593 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 930781008594 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930781008595 ATP binding site [chemical binding]; other site 930781008596 Mg++ binding site [ion binding]; other site 930781008597 motif III; other site 930781008598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930781008599 nucleotide binding region [chemical binding]; other site 930781008600 ATP-binding site [chemical binding]; other site 930781008601 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 930781008602 RNA binding site [nucleotide binding]; other site 930781008603 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781008604 catalytic core [active] 930781008605 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930781008606 dimer interface [polypeptide binding]; other site 930781008607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781008608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 930781008609 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 930781008610 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930781008611 Uncharacterized conserved protein [Function unknown]; Region: COG5361 930781008612 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 930781008613 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 930781008614 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 930781008615 active site 930781008616 metal binding site [ion binding]; metal-binding site 930781008617 homotetramer interface [polypeptide binding]; other site 930781008618 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 930781008619 active site 930781008620 dimerization interface [polypeptide binding]; other site 930781008621 ribonuclease PH; Reviewed; Region: rph; PRK00173 930781008622 Ribonuclease PH; Region: RNase_PH_bact; cd11362 930781008623 hexamer interface [polypeptide binding]; other site 930781008624 active site 930781008625 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 930781008626 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 930781008627 aspartate kinase; Reviewed; Region: PRK06635 930781008628 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 930781008629 putative nucleotide binding site [chemical binding]; other site 930781008630 putative catalytic residues [active] 930781008631 putative Mg ion binding site [ion binding]; other site 930781008632 putative aspartate binding site [chemical binding]; other site 930781008633 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 930781008634 putative allosteric regulatory site; other site 930781008635 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 930781008636 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930781008637 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930781008638 GIY-YIG motif/motif A; other site 930781008639 active site 930781008640 catalytic site [active] 930781008641 putative DNA binding site [nucleotide binding]; other site 930781008642 metal binding site [ion binding]; metal-binding site 930781008643 UvrB/uvrC motif; Region: UVR; pfam02151 930781008644 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 930781008645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930781008646 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930781008647 catalytic residues [active] 930781008648 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 930781008649 MutS domain III; Region: MutS_III; pfam05192 930781008650 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781008651 Walker A/P-loop; other site 930781008652 ATP binding site [chemical binding]; other site 930781008653 Q-loop/lid; other site 930781008654 ABC transporter signature motif; other site 930781008655 Walker B; other site 930781008656 D-loop; other site 930781008657 H-loop/switch region; other site 930781008658 Smr domain; Region: Smr; pfam01713 930781008659 hypothetical protein; Provisional; Region: PRK08609 930781008660 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 930781008661 active site 930781008662 primer binding site [nucleotide binding]; other site 930781008663 NTP binding site [chemical binding]; other site 930781008664 metal binding triad [ion binding]; metal-binding site 930781008665 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 930781008666 active site 930781008667 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 930781008668 Colicin V production protein; Region: Colicin_V; pfam02674 930781008669 Cell division protein ZapA; Region: ZapA; cl01146 930781008670 ribonuclease HIII; Provisional; Region: PRK00996 930781008671 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 930781008672 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 930781008673 RNA/DNA hybrid binding site [nucleotide binding]; other site 930781008674 active site 930781008675 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930781008676 ligand binding site [chemical binding]; other site 930781008677 active site 930781008678 UGI interface [polypeptide binding]; other site 930781008679 catalytic site [active] 930781008680 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930781008681 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930781008682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930781008683 putative DNA binding site [nucleotide binding]; other site 930781008684 putative Zn2+ binding site [ion binding]; other site 930781008685 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781008686 FtsX-like permease family; Region: FtsX; pfam02687 930781008687 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930781008688 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930781008689 FtsX-like permease family; Region: FtsX; pfam02687 930781008690 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930781008691 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930781008692 Walker A/P-loop; other site 930781008693 ATP binding site [chemical binding]; other site 930781008694 Q-loop/lid; other site 930781008695 ABC transporter signature motif; other site 930781008696 Walker B; other site 930781008697 D-loop; other site 930781008698 H-loop/switch region; other site 930781008699 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 930781008700 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930781008701 putative tRNA-binding site [nucleotide binding]; other site 930781008702 B3/4 domain; Region: B3_4; pfam03483 930781008703 tRNA synthetase B5 domain; Region: B5; smart00874 930781008704 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 930781008705 dimer interface [polypeptide binding]; other site 930781008706 motif 1; other site 930781008707 motif 3; other site 930781008708 motif 2; other site 930781008709 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 930781008710 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 930781008711 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 930781008712 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 930781008713 dimer interface [polypeptide binding]; other site 930781008714 motif 1; other site 930781008715 active site 930781008716 motif 2; other site 930781008717 motif 3; other site 930781008718 Predicted transcriptional regulators [Transcription]; Region: COG1733 930781008719 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930781008720 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930781008721 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 930781008722 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930781008723 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930781008724 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930781008725 oligomer interface [polypeptide binding]; other site 930781008726 active site 930781008727 metal binding site [ion binding]; metal-binding site 930781008728 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781008729 SH3-like domain; Region: SH3_8; pfam13457 930781008730 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930781008731 SH3-like domain; Region: SH3_8; pfam13457 930781008732 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 930781008733 Predicted transcriptional regulators [Transcription]; Region: COG1695 930781008734 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930781008735 AAA domain; Region: AAA_17; cl17253 930781008736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 930781008737 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 930781008738 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 930781008739 cobyric acid synthase; Provisional; Region: PRK00784 930781008740 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930781008741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930781008742 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 930781008743 catalytic triad [active] 930781008744 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 930781008745 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930781008746 Walker A/P-loop; other site 930781008747 ATP binding site [chemical binding]; other site 930781008748 Q-loop/lid; other site 930781008749 ABC transporter signature motif; other site 930781008750 Walker B; other site 930781008751 D-loop; other site 930781008752 H-loop/switch region; other site 930781008753 cobalt transport protein CbiQ; Provisional; Region: PRK15485 930781008754 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 930781008755 cobalt transport protein CbiM; Validated; Region: PRK08319 930781008756 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 930781008757 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 930781008758 active site 930781008759 SAM binding site [chemical binding]; other site 930781008760 homodimer interface [polypeptide binding]; other site 930781008761 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 930781008762 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 930781008763 active site 930781008764 C-terminal domain interface [polypeptide binding]; other site 930781008765 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 930781008766 active site 930781008767 N-terminal domain interface [polypeptide binding]; other site 930781008768 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930781008769 active site 930781008770 SAM binding site [chemical binding]; other site 930781008771 homodimer interface [polypeptide binding]; other site 930781008772 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 930781008773 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930781008774 active site 930781008775 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 930781008776 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 930781008777 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 930781008778 active site 930781008779 SAM binding site [chemical binding]; other site 930781008780 homodimer interface [polypeptide binding]; other site 930781008781 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 930781008782 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 930781008783 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 930781008784 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 930781008785 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 930781008786 active site 930781008787 SAM binding site [chemical binding]; other site 930781008788 homodimer interface [polypeptide binding]; other site 930781008789 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 930781008790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930781008791 S-adenosylmethionine binding site [chemical binding]; other site 930781008792 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 930781008793 active site 930781008794 putative homodimer interface [polypeptide binding]; other site 930781008795 SAM binding site [chemical binding]; other site 930781008796 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 930781008797 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 930781008798 Precorrin-8X methylmutase; Region: CbiC; pfam02570 930781008799 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 930781008800 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 930781008801 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930781008802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781008803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781008804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781008805 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 930781008806 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 930781008807 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 930781008808 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 930781008809 putative hexamer interface [polypeptide binding]; other site 930781008810 putative hexagonal pore; other site 930781008811 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 930781008812 putative hexamer interface [polypeptide binding]; other site 930781008813 putative hexagonal pore; other site 930781008814 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 930781008815 Hexamer/Pentamer interface [polypeptide binding]; other site 930781008816 central pore; other site 930781008817 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 930781008818 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 930781008819 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930781008820 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930781008821 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 930781008822 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008823 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 930781008824 Hexamer interface [polypeptide binding]; other site 930781008825 Putative hexagonal pore residue; other site 930781008826 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 930781008827 putative catalytic cysteine [active] 930781008828 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008829 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930781008830 Hexamer interface [polypeptide binding]; other site 930781008831 Hexagonal pore residue; other site 930781008832 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 930781008833 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 930781008834 putative hexamer interface [polypeptide binding]; other site 930781008835 putative hexagonal pore; other site 930781008836 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 930781008837 putative hexamer interface [polypeptide binding]; other site 930781008838 putative hexagonal pore; other site 930781008839 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 930781008840 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 930781008841 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 930781008842 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 930781008843 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 930781008844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 930781008845 Histidine kinase; Region: HisKA_2; pfam07568 930781008846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930781008847 ATP binding site [chemical binding]; other site 930781008848 Mg2+ binding site [ion binding]; other site 930781008849 G-X-G motif; other site 930781008850 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 930781008851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930781008852 active site 930781008853 phosphorylation site [posttranslational modification] 930781008854 intermolecular recognition site; other site 930781008855 dimerization interface [polypeptide binding]; other site 930781008856 ANTAR domain; Region: ANTAR; pfam03861 930781008857 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930781008858 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 930781008859 putative active site [active] 930781008860 metal binding site [ion binding]; metal-binding site 930781008861 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 930781008862 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 930781008863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930781008864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930781008865 homodimer interface [polypeptide binding]; other site 930781008866 catalytic residue [active] 930781008867 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930781008868 propionate/acetate kinase; Provisional; Region: PRK12379 930781008869 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 930781008870 amphipathic channel; other site 930781008871 Asn-Pro-Ala signature motifs; other site 930781008872 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930781008873 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 930781008874 putative active site [active] 930781008875 metal binding site [ion binding]; metal-binding site 930781008876 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 930781008877 putative catalytic cysteine [active] 930781008878 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 930781008879 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 930781008880 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 930781008881 Hexamer/Pentamer interface [polypeptide binding]; other site 930781008882 central pore; other site 930781008883 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 930781008884 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 930781008885 Cell division protein FtsA; Region: FtsA; cl17206 930781008886 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930781008887 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 930781008888 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930781008889 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930781008890 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008891 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930781008892 Hexamer interface [polypeptide binding]; other site 930781008893 Hexagonal pore residue; other site 930781008894 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008895 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 930781008896 putative hexamer interface [polypeptide binding]; other site 930781008897 putative hexagonal pore; other site 930781008898 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 930781008899 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 930781008900 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 930781008901 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 930781008902 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 930781008903 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 930781008904 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 930781008905 alpha-beta subunit interface [polypeptide binding]; other site 930781008906 alpha-gamma subunit interface [polypeptide binding]; other site 930781008907 active site 930781008908 substrate and K+ binding site; other site 930781008909 K+ binding site [ion binding]; other site 930781008910 cobalamin binding site [chemical binding]; other site 930781008911 propanediol utilization protein PduB; Provisional; Region: PRK15415 930781008912 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 930781008913 putative hexamer interface [polypeptide binding]; other site 930781008914 putative hexagonal pore; other site 930781008915 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 930781008916 putative hexamer interface [polypeptide binding]; other site 930781008917 putative hexagonal pore; other site 930781008918 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008919 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930781008920 Hexamer interface [polypeptide binding]; other site 930781008921 Hexagonal pore residue; other site 930781008922 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 930781008923 Sensory domain found in PocR; Region: PocR; pfam10114 930781008924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781008925 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781008926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781008927 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930781008928 catalytic core [active] 930781008929 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 930781008930 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 930781008931 homotrimer interface [polypeptide binding]; other site 930781008932 Walker A motif; other site 930781008933 GTP binding site [chemical binding]; other site 930781008934 Walker B motif; other site 930781008935 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 930781008936 G1 box; other site 930781008937 GTP/Mg2+ binding site [chemical binding]; other site 930781008938 G2 box; other site 930781008939 Switch I region; other site 930781008940 G3 box; other site 930781008941 Switch II region; other site 930781008942 G4 box; other site 930781008943 G5 box; other site 930781008944 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 930781008945 putative hexamer interface [polypeptide binding]; other site 930781008946 putative hexagonal pore; other site 930781008947 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930781008948 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 930781008949 putative hexamer interface [polypeptide binding]; other site 930781008950 putative hexagonal pore; other site 930781008951 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 930781008952 putative hexamer interface [polypeptide binding]; other site 930781008953 putative hexagonal pore; other site 930781008954 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 930781008955 SLBB domain; Region: SLBB; pfam10531 930781008956 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 930781008957 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 930781008958 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 930781008959 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 930781008960 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930781008961 dimer interface [polypeptide binding]; other site 930781008962 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781008963 Clp protease; Region: CLP_protease; pfam00574 930781008964 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930781008965 oligomer interface [polypeptide binding]; other site 930781008966 active site residues [active] 930781008967 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 930781008968 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930781008969 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930781008970 LRR adjacent; Region: LRR_adjacent; pfam08191 930781008971 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930781008972 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930781008973 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930781008974 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930781008975 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781008976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781008977 Walker A/P-loop; other site 930781008978 ATP binding site [chemical binding]; other site 930781008979 Q-loop/lid; other site 930781008980 ABC transporter signature motif; other site 930781008981 Walker B; other site 930781008982 D-loop; other site 930781008983 H-loop/switch region; other site 930781008984 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 930781008985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930781008986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930781008987 Walker A/P-loop; other site 930781008988 ATP binding site [chemical binding]; other site 930781008989 Q-loop/lid; other site 930781008990 ABC transporter signature motif; other site 930781008991 Walker B; other site 930781008992 D-loop; other site 930781008993 H-loop/switch region; other site 930781008994 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930781008995 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 930781008996 DNA binding residues [nucleotide binding] 930781008997 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930781008998 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930781008999 Coenzyme A binding pocket [chemical binding]; other site 930781009000 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930781009001 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930781009002 MepB protein; Region: MepB; cl01985 930781009003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930781009004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930781009005 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 930781009006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930781009007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930781009008 active site 930781009009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781009010 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930781009011 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930781009012 YcaO-like family; Region: YcaO; pfam02624 930781009013 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 930781009014 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 930781009015 putative FMN binding site [chemical binding]; other site 930781009016 NADPH bind site [chemical binding]; other site