-- dump date 20140619_132818 -- class Genbank::misc_feature -- table misc_feature_note -- id note 930782000001 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 930782000002 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 930782000003 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 930782000004 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 930782000005 ADP binding site [chemical binding]; other site 930782000006 phosphagen binding site; other site 930782000007 substrate specificity loop; other site 930782000008 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 930782000009 Clp amino terminal domain; Region: Clp_N; pfam02861 930782000010 Clp amino terminal domain; Region: Clp_N; pfam02861 930782000011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782000012 Walker A motif; other site 930782000013 ATP binding site [chemical binding]; other site 930782000014 Walker B motif; other site 930782000015 arginine finger; other site 930782000016 UvrB/uvrC motif; Region: UVR; pfam02151 930782000017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782000018 Walker A motif; other site 930782000019 ATP binding site [chemical binding]; other site 930782000020 Walker B motif; other site 930782000021 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930782000022 DNA repair protein RadA; Provisional; Region: PRK11823 930782000023 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 930782000024 Walker A motif/ATP binding site; other site 930782000025 ATP binding site [chemical binding]; other site 930782000026 Walker B motif; other site 930782000027 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 930782000028 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 930782000029 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 930782000030 putative active site [active] 930782000031 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930782000032 substrate binding site; other site 930782000033 dimer interface; other site 930782000034 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 930782000035 homotrimer interaction site [polypeptide binding]; other site 930782000036 zinc binding site [ion binding]; other site 930782000037 CDP-binding sites; other site 930782000038 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 930782000039 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930782000040 HIGH motif; other site 930782000041 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 930782000042 active site 930782000043 KMSKS motif; other site 930782000044 serine O-acetyltransferase; Region: cysE; TIGR01172 930782000045 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 930782000046 trimer interface [polypeptide binding]; other site 930782000047 active site 930782000048 substrate binding site [chemical binding]; other site 930782000049 CoA binding site [chemical binding]; other site 930782000050 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 930782000051 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930782000052 active site 930782000053 HIGH motif; other site 930782000054 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 930782000055 KMSKS motif; other site 930782000056 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 930782000057 tRNA binding surface [nucleotide binding]; other site 930782000058 anticodon binding site; other site 930782000059 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930782000060 active site 930782000061 metal binding site [ion binding]; metal-binding site 930782000062 dimerization interface [polypeptide binding]; other site 930782000063 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930782000064 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 930782000065 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930782000066 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 930782000067 RNA polymerase factor sigma-70; Validated; Region: PRK08295 930782000068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930782000069 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 930782000070 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 930782000071 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 930782000072 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 930782000073 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 930782000074 putative homodimer interface [polypeptide binding]; other site 930782000075 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 930782000076 heterodimer interface [polypeptide binding]; other site 930782000077 homodimer interface [polypeptide binding]; other site 930782000078 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 930782000079 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 930782000080 23S rRNA interface [nucleotide binding]; other site 930782000081 L7/L12 interface [polypeptide binding]; other site 930782000082 putative thiostrepton binding site; other site 930782000083 L25 interface [polypeptide binding]; other site 930782000084 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 930782000085 mRNA/rRNA interface [nucleotide binding]; other site 930782000086 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 930782000087 23S rRNA interface [nucleotide binding]; other site 930782000088 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 930782000089 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 930782000090 core dimer interface [polypeptide binding]; other site 930782000091 peripheral dimer interface [polypeptide binding]; other site 930782000092 L10 interface [polypeptide binding]; other site 930782000093 L11 interface [polypeptide binding]; other site 930782000094 putative EF-Tu interaction site [polypeptide binding]; other site 930782000095 putative EF-G interaction site [polypeptide binding]; other site 930782000096 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930782000097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782000098 S-adenosylmethionine binding site [chemical binding]; other site 930782000099 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 930782000100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782000101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782000102 DNA binding site [nucleotide binding] 930782000103 domain linker motif; other site 930782000104 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930782000105 putative dimerization interface [polypeptide binding]; other site 930782000106 putative ligand binding site [chemical binding]; other site 930782000107 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 930782000108 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782000109 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930782000110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782000111 dimer interface [polypeptide binding]; other site 930782000112 conserved gate region; other site 930782000113 putative PBP binding loops; other site 930782000114 ABC-ATPase subunit interface; other site 930782000115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782000116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782000117 dimer interface [polypeptide binding]; other site 930782000118 conserved gate region; other site 930782000119 putative PBP binding loops; other site 930782000120 ABC-ATPase subunit interface; other site 930782000121 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930782000122 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930782000123 Ca binding site [ion binding]; other site 930782000124 active site 930782000125 catalytic site [active] 930782000126 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 930782000127 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 930782000128 active site 930782000129 homodimer interface [polypeptide binding]; other site 930782000130 catalytic site [active] 930782000131 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 930782000132 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930782000133 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930782000134 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 930782000135 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 930782000136 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 930782000137 RPB10 interaction site [polypeptide binding]; other site 930782000138 RPB1 interaction site [polypeptide binding]; other site 930782000139 RPB11 interaction site [polypeptide binding]; other site 930782000140 RPB3 interaction site [polypeptide binding]; other site 930782000141 RPB12 interaction site [polypeptide binding]; other site 930782000142 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 930782000143 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 930782000144 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 930782000145 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 930782000146 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 930782000147 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930782000148 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 930782000149 G-loop; other site 930782000150 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 930782000151 DNA binding site [nucleotide binding] 930782000152 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 930782000153 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 930782000154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000155 active site 930782000156 motif I; other site 930782000157 motif II; other site 930782000158 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782000159 beta-galactosidase; Region: BGL; TIGR03356 930782000160 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930782000161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 930782000162 Walker A/P-loop; other site 930782000163 ATP binding site [chemical binding]; other site 930782000164 Q-loop/lid; other site 930782000165 ABC transporter signature motif; other site 930782000166 Walker B; other site 930782000167 D-loop; other site 930782000168 H-loop/switch region; other site 930782000169 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930782000170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782000171 Walker A/P-loop; other site 930782000172 ATP binding site [chemical binding]; other site 930782000173 Q-loop/lid; other site 930782000174 ABC transporter signature motif; other site 930782000175 Walker B; other site 930782000176 D-loop; other site 930782000177 H-loop/switch region; other site 930782000178 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782000179 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000180 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782000181 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000182 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000183 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000184 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000185 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000186 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000187 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000188 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000189 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000190 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000191 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000192 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000193 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000194 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000195 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000196 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000197 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000198 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000199 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000200 Leucine-rich repeats; other site 930782000201 Substrate binding site [chemical binding]; other site 930782000202 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000203 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000204 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000205 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000206 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000207 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000208 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000209 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 930782000210 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 930782000211 metal binding site [ion binding]; metal-binding site 930782000212 dimer interface [polypeptide binding]; other site 930782000213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782000214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782000215 putative Zn2+ binding site [ion binding]; other site 930782000216 putative DNA binding site [nucleotide binding]; other site 930782000217 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930782000218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782000219 Zn binding site [ion binding]; other site 930782000220 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930782000221 Zn binding site [ion binding]; other site 930782000222 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782000223 catalytic core [active] 930782000224 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 930782000225 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930782000226 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930782000227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782000228 dimer interface [polypeptide binding]; other site 930782000229 conserved gate region; other site 930782000230 ABC-ATPase subunit interface; other site 930782000231 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000232 Substrate binding site [chemical binding]; other site 930782000233 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000234 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000235 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000236 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000237 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000238 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 930782000239 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782000240 beta-galactosidase; Region: BGL; TIGR03356 930782000241 sugar phosphate phosphatase; Provisional; Region: PRK10513 930782000242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000243 active site 930782000244 motif I; other site 930782000245 motif II; other site 930782000246 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782000248 Coenzyme A binding pocket [chemical binding]; other site 930782000249 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782000250 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 930782000251 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930782000252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930782000253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000254 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 930782000255 active site 930782000256 motif I; other site 930782000257 motif II; other site 930782000258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000259 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782000260 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782000261 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930782000262 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 930782000263 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 930782000264 Walker A/P-loop; other site 930782000265 ATP binding site [chemical binding]; other site 930782000266 Q-loop/lid; other site 930782000267 ABC transporter signature motif; other site 930782000268 Walker B; other site 930782000269 D-loop; other site 930782000270 H-loop/switch region; other site 930782000271 TOBE domain; Region: TOBE; pfam03459 930782000272 ATP cone domain; Region: ATP-cone; pfam03477 930782000273 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 930782000274 Class III ribonucleotide reductase; Region: RNR_III; cd01675 930782000275 effector binding site; other site 930782000276 active site 930782000277 Zn binding site [ion binding]; other site 930782000278 glycine loop; other site 930782000279 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 930782000280 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 930782000281 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782000282 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782000283 ligand binding site [chemical binding]; other site 930782000284 flexible hinge region; other site 930782000285 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930782000286 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 930782000287 putative active site [active] 930782000288 catalytic triad [active] 930782000289 putative dimer interface [polypeptide binding]; other site 930782000290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782000291 dimer interface [polypeptide binding]; other site 930782000292 conserved gate region; other site 930782000293 ABC-ATPase subunit interface; other site 930782000294 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 930782000295 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930782000296 Walker A/P-loop; other site 930782000297 ATP binding site [chemical binding]; other site 930782000298 Q-loop/lid; other site 930782000299 ABC transporter signature motif; other site 930782000300 Walker B; other site 930782000301 D-loop; other site 930782000302 H-loop/switch region; other site 930782000303 NIL domain; Region: NIL; pfam09383 930782000304 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930782000305 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930782000306 transaminase; Reviewed; Region: PRK08068 930782000307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782000308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782000309 homodimer interface [polypeptide binding]; other site 930782000310 catalytic residue [active] 930782000311 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782000312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782000313 active site 930782000314 phosphorylation site [posttranslational modification] 930782000315 intermolecular recognition site; other site 930782000316 dimerization interface [polypeptide binding]; other site 930782000317 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782000318 DNA binding site [nucleotide binding] 930782000319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 930782000320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782000321 dimerization interface [polypeptide binding]; other site 930782000322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930782000323 putative active site [active] 930782000324 heme pocket [chemical binding]; other site 930782000325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782000326 dimer interface [polypeptide binding]; other site 930782000327 phosphorylation site [posttranslational modification] 930782000328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782000329 ATP binding site [chemical binding]; other site 930782000330 Mg2+ binding site [ion binding]; other site 930782000331 G-X-G motif; other site 930782000332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 930782000333 YycH protein; Region: YycH; pfam07435 930782000334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 930782000335 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 930782000336 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930782000337 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930782000338 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 930782000339 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930782000340 protein binding site [polypeptide binding]; other site 930782000341 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 930782000342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782000343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782000344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930782000345 dimerization interface [polypeptide binding]; other site 930782000346 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930782000347 dimer interface [polypeptide binding]; other site 930782000348 FMN binding site [chemical binding]; other site 930782000349 NADPH bind site [chemical binding]; other site 930782000350 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782000351 HTH domain; Region: HTH_11; pfam08279 930782000352 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782000353 PRD domain; Region: PRD; pfam00874 930782000354 PRD domain; Region: PRD; pfam00874 930782000355 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782000356 active site 930782000357 P-loop; other site 930782000358 phosphorylation site [posttranslational modification] 930782000359 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000360 active site 930782000361 phosphorylation site [posttranslational modification] 930782000362 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782000363 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782000364 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782000365 active site 930782000366 P-loop; other site 930782000367 phosphorylation site [posttranslational modification] 930782000368 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782000369 beta-galactosidase; Region: BGL; TIGR03356 930782000370 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782000371 methionine cluster; other site 930782000372 active site 930782000373 phosphorylation site [posttranslational modification] 930782000374 metal binding site [ion binding]; metal-binding site 930782000375 HsdM N-terminal domain; Region: HsdM_N; pfam12161 930782000376 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 930782000377 Methyltransferase domain; Region: Methyltransf_26; pfam13659 930782000378 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 930782000379 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 930782000380 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 930782000381 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 930782000382 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 930782000383 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 930782000384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782000385 ATP binding site [chemical binding]; other site 930782000386 putative Mg++ binding site [ion binding]; other site 930782000387 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 930782000388 Mrr N-terminal domain; Region: Mrr_N; pfam14338 930782000389 Restriction endonuclease; Region: Mrr_cat; pfam04471 930782000390 Part of AAA domain; Region: AAA_19; pfam13245 930782000391 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 930782000392 AAA domain; Region: AAA_12; pfam13087 930782000393 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 930782000394 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930782000395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782000396 catalytic residue [active] 930782000397 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 930782000398 putative active site [active] 930782000399 YdjC motif; other site 930782000400 Mg binding site [ion binding]; other site 930782000401 putative homodimer interface [polypeptide binding]; other site 930782000402 Putative transcription activator [Transcription]; Region: TenA; COG0819 930782000403 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 930782000404 substrate binding site [chemical binding]; other site 930782000405 multimerization interface [polypeptide binding]; other site 930782000406 ATP binding site [chemical binding]; other site 930782000407 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930782000408 dimer interface [polypeptide binding]; other site 930782000409 substrate binding site [chemical binding]; other site 930782000410 ATP binding site [chemical binding]; other site 930782000411 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 930782000412 thiamine phosphate binding site [chemical binding]; other site 930782000413 active site 930782000414 pyrophosphate binding site [ion binding]; other site 930782000415 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782000416 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782000417 non-specific DNA binding site [nucleotide binding]; other site 930782000418 salt bridge; other site 930782000419 sequence-specific DNA binding site [nucleotide binding]; other site 930782000420 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 930782000421 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930782000422 cofactor binding site; other site 930782000423 DNA binding site [nucleotide binding] 930782000424 substrate interaction site [chemical binding]; other site 930782000425 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 930782000426 ATP binding site [chemical binding]; other site 930782000427 Mg2+ binding site [ion binding]; other site 930782000428 G-X-G motif; other site 930782000429 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782000430 beta-galactosidase; Region: BGL; TIGR03356 930782000431 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000432 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 930782000433 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 930782000434 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 930782000435 putative catalytic site [active] 930782000436 putative metal binding site [ion binding]; other site 930782000437 putative phosphate binding site [ion binding]; other site 930782000438 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782000439 non-specific DNA binding site [nucleotide binding]; other site 930782000440 salt bridge; other site 930782000441 sequence-specific DNA binding site [nucleotide binding]; other site 930782000442 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930782000443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782000444 non-specific DNA binding site [nucleotide binding]; other site 930782000445 salt bridge; other site 930782000446 sequence-specific DNA binding site [nucleotide binding]; other site 930782000447 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930782000448 Leucine rich repeat; Region: LRR_8; pfam13855 930782000449 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000450 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000451 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000452 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000453 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000454 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000455 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000456 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000457 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000458 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000459 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000460 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000461 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000462 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000463 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000464 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000465 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000466 Leucine rich repeat; Region: LRR_8; pfam13855 930782000467 Leucine rich repeat; Region: LRR_8; pfam13855 930782000468 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000469 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000470 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000471 Leucine-rich repeats; other site 930782000472 Substrate binding site [chemical binding]; other site 930782000473 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000474 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000475 Leucine rich repeat; Region: LRR_8; pfam13855 930782000476 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000477 Leucine-rich repeats; other site 930782000478 Leucine rich repeat; Region: LRR_8; pfam13855 930782000479 Substrate binding site [chemical binding]; other site 930782000480 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000481 Leucine rich repeat; Region: LRR_8; pfam13855 930782000482 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000483 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000484 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000485 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000486 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000487 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000488 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782000489 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 930782000490 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 930782000491 LXG domain of WXG superfamily; Region: LXG; pfam04740 930782000492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782000493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782000494 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930782000495 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930782000496 NAD binding site [chemical binding]; other site 930782000497 substrate binding site [chemical binding]; other site 930782000498 putative active site [active] 930782000499 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930782000500 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930782000501 Magnesium ion binding site [ion binding]; other site 930782000502 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 930782000503 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930782000504 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930782000505 TPP-binding site [chemical binding]; other site 930782000506 dimer interface [polypeptide binding]; other site 930782000507 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930782000508 PYR/PP interface [polypeptide binding]; other site 930782000509 dimer interface [polypeptide binding]; other site 930782000510 TPP binding site [chemical binding]; other site 930782000511 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782000512 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930782000513 active site 930782000514 intersubunit interactions; other site 930782000515 catalytic residue [active] 930782000516 short chain dehydrogenase; Provisional; Region: PRK06841 930782000517 classical (c) SDRs; Region: SDR_c; cd05233 930782000518 NAD(P) binding site [chemical binding]; other site 930782000519 active site 930782000520 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930782000521 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930782000522 substrate binding site [chemical binding]; other site 930782000523 dimer interface [polypeptide binding]; other site 930782000524 catalytic triad [active] 930782000525 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930782000526 DAK2 domain; Region: Dak2; cl03685 930782000527 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 930782000528 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930782000529 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 930782000530 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782000531 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782000532 putative DNA binding site [nucleotide binding]; other site 930782000533 putative Zn2+ binding site [ion binding]; other site 930782000534 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782000535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782000536 Coenzyme A binding pocket [chemical binding]; other site 930782000537 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000538 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782000539 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000540 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000541 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000542 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 930782000543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930782000544 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 930782000545 acyl-activating enzyme (AAE) consensus motif; other site 930782000546 acyl-activating enzyme (AAE) consensus motif; other site 930782000547 AMP binding site [chemical binding]; other site 930782000548 active site 930782000549 CoA binding site [chemical binding]; other site 930782000550 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 930782000551 L-aspartate oxidase; Provisional; Region: PRK06175 930782000552 putative oxidoreductase; Provisional; Region: PRK10206 930782000553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782000554 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930782000555 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930782000556 intersubunit interface [polypeptide binding]; other site 930782000557 active site 930782000558 zinc binding site [ion binding]; other site 930782000559 Na+ binding site [ion binding]; other site 930782000560 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782000561 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 930782000562 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782000563 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930782000564 conserved cys residue [active] 930782000565 Predicted transcriptional regulator [Transcription]; Region: COG2378 930782000566 HTH domain; Region: HTH_11; pfam08279 930782000567 WYL domain; Region: WYL; pfam13280 930782000568 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 930782000569 nudix motif; other site 930782000570 hypothetical protein; Provisional; Region: PRK12378 930782000571 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 930782000572 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 930782000573 PhnA protein; Region: PhnA; pfam03831 930782000574 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782000575 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782000576 DNA-binding site [nucleotide binding]; DNA binding site 930782000577 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930782000578 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782000579 beta-galactosidase; Region: BGL; TIGR03356 930782000580 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782000581 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 930782000582 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782000583 active site 930782000584 P-loop; other site 930782000585 phosphorylation site [posttranslational modification] 930782000586 Predicted transcriptional regulator [Transcription]; Region: COG2378 930782000587 HTH domain; Region: HTH_11; pfam08279 930782000588 WYL domain; Region: WYL; pfam13280 930782000589 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930782000590 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782000591 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930782000592 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782000593 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 930782000594 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 930782000595 tetrameric interface [polypeptide binding]; other site 930782000596 NAD binding site [chemical binding]; other site 930782000597 catalytic residues [active] 930782000598 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 930782000599 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930782000600 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 930782000601 substrate binding site [chemical binding]; other site 930782000602 ATP binding site [chemical binding]; other site 930782000603 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 930782000604 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930782000605 PYR/PP interface [polypeptide binding]; other site 930782000606 dimer interface [polypeptide binding]; other site 930782000607 TPP binding site [chemical binding]; other site 930782000608 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930782000609 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 930782000610 TPP-binding site; other site 930782000611 Uncharacterized conserved protein [Function unknown]; Region: COG5646 930782000612 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 930782000613 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930782000614 ligand binding site [chemical binding]; other site 930782000615 active site 930782000616 UGI interface [polypeptide binding]; other site 930782000617 catalytic site [active] 930782000618 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 930782000619 hypothetical protein; Provisional; Region: PRK13665 930782000620 Bacterial SH3 domain; Region: SH3_3; cl17532 930782000621 NlpC/P60 family; Region: NLPC_P60; pfam00877 930782000622 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782000623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782000624 Coenzyme A binding pocket [chemical binding]; other site 930782000625 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 930782000626 pyrroline-5-carboxylate reductase; Region: PLN02688 930782000627 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782000628 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000629 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930782000630 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782000631 DNA-binding site [nucleotide binding]; DNA binding site 930782000632 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930782000633 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782000634 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782000635 Walker A/P-loop; other site 930782000636 ATP binding site [chemical binding]; other site 930782000637 Q-loop/lid; other site 930782000638 ABC transporter signature motif; other site 930782000639 Walker B; other site 930782000640 D-loop; other site 930782000641 H-loop/switch region; other site 930782000642 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782000643 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782000644 FtsX-like permease family; Region: FtsX; pfam02687 930782000645 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 930782000646 putative hydrophobic ligand binding site [chemical binding]; other site 930782000647 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000648 active site 930782000649 phosphorylation site [posttranslational modification] 930782000650 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930782000651 active site 930782000652 P-loop; other site 930782000653 phosphorylation site [posttranslational modification] 930782000654 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930782000655 alpha-mannosidase; Provisional; Region: PRK09819 930782000656 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930782000657 active site 930782000658 metal binding site [ion binding]; metal-binding site 930782000659 catalytic site [active] 930782000660 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930782000661 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782000662 HTH domain; Region: HTH_11; pfam08279 930782000663 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782000664 PRD domain; Region: PRD; pfam00874 930782000665 PRD domain; Region: PRD; pfam00874 930782000666 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782000667 active site 930782000668 P-loop; other site 930782000669 phosphorylation site [posttranslational modification] 930782000670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000671 active site 930782000672 phosphorylation site [posttranslational modification] 930782000673 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930782000674 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 930782000675 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782000676 putative metal binding site [ion binding]; other site 930782000677 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 930782000678 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 930782000679 trimer interface [polypeptide binding]; other site 930782000680 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000681 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000682 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000683 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000684 Leucine-rich repeats; other site 930782000685 Substrate binding site [chemical binding]; other site 930782000686 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000687 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000688 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000689 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000690 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000691 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000692 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000693 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000694 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000695 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000696 phosphoenolpyruvate synthase; Validated; Region: PRK06241 930782000697 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930782000698 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930782000699 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 930782000700 ZIP Zinc transporter; Region: Zip; pfam02535 930782000701 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 930782000702 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 930782000703 NodB motif; other site 930782000704 active site 930782000705 catalytic site [active] 930782000706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782000707 non-specific DNA binding site [nucleotide binding]; other site 930782000708 salt bridge; other site 930782000709 sequence-specific DNA binding site [nucleotide binding]; other site 930782000710 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 930782000711 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782000712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000713 active site 930782000714 motif I; other site 930782000715 motif II; other site 930782000716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782000717 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930782000718 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782000719 HTH domain; Region: HTH_11; pfam08279 930782000720 PRD domain; Region: PRD; pfam00874 930782000721 PRD domain; Region: PRD; pfam00874 930782000722 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782000723 active site 930782000724 P-loop; other site 930782000725 phosphorylation site [posttranslational modification] 930782000726 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000727 active site 930782000728 phosphorylation site [posttranslational modification] 930782000729 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000730 active site 930782000731 phosphorylation site [posttranslational modification] 930782000732 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930782000733 active site 930782000734 P-loop; other site 930782000735 phosphorylation site [posttranslational modification] 930782000736 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930782000737 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930782000738 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930782000739 active site 930782000740 metal binding site [ion binding]; metal-binding site 930782000741 catalytic site [active] 930782000742 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 930782000743 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782000744 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782000745 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930782000746 dimerization interface [polypeptide binding]; other site 930782000747 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 930782000748 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930782000749 active site 930782000750 substrate binding site [chemical binding]; other site 930782000751 trimer interface [polypeptide binding]; other site 930782000752 CoA binding site [chemical binding]; other site 930782000753 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 930782000754 classical (c) SDRs; Region: SDR_c; cd05233 930782000755 NAD(P) binding site [chemical binding]; other site 930782000756 active site 930782000757 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 930782000758 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 930782000759 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 930782000760 RHS Repeat; Region: RHS_repeat; pfam05593 930782000761 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 930782000762 RHS Repeat; Region: RHS_repeat; pfam05593 930782000763 RHS Repeat; Region: RHS_repeat; pfam05593 930782000764 RHS Repeat; Region: RHS_repeat; pfam05593 930782000765 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 930782000766 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000767 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782000768 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000769 Substrate binding site [chemical binding]; other site 930782000770 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000771 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000772 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000773 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000774 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 930782000775 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782000776 Leucine rich repeat; Region: LRR_8; pfam13855 930782000777 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782000778 Leucine rich repeat; Region: LRR_8; pfam13855 930782000779 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000780 LRR adjacent; Region: LRR_adjacent; pfam08191 930782000781 Listeria/Bacterioides repeat; Region: List_Bact_rpt; TIGR02543 930782000782 SH3-like domain; Region: SH3_8; pfam13457 930782000783 Predicted transcriptional regulator [Transcription]; Region: COG1959 930782000784 Transcriptional regulator; Region: Rrf2; pfam02082 930782000785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930782000786 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 930782000787 NAD(P) binding site [chemical binding]; other site 930782000788 active site 930782000789 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 930782000790 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 930782000791 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 930782000792 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 930782000793 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930782000794 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930782000795 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930782000796 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 930782000797 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 930782000798 Predicted membrane protein [Function unknown]; Region: COG3619 930782000799 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 930782000800 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 930782000801 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 930782000802 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 930782000803 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 930782000804 Protein of unknown function DUF58; Region: DUF58; pfam01882 930782000805 MoxR-like ATPases [General function prediction only]; Region: COG0714 930782000806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782000807 Walker A motif; other site 930782000808 ATP binding site [chemical binding]; other site 930782000809 Walker B motif; other site 930782000810 arginine finger; other site 930782000811 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 930782000812 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930782000813 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 930782000814 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 930782000815 Na binding site [ion binding]; other site 930782000816 Uncharacterized conserved protein [Function unknown]; Region: COG3535 930782000817 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 930782000818 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782000819 nucleotide binding site [chemical binding]; other site 930782000820 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 930782000821 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782000822 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782000823 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000824 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000825 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000826 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000827 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000828 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 930782000829 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000830 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000831 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782000832 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000833 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000834 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000835 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782000836 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000837 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000838 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782000839 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782000840 RWP-RK domain; Region: RWP-RK; pfam02042 930782000841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782000842 Zn2+ binding site [ion binding]; other site 930782000843 Mg2+ binding site [ion binding]; other site 930782000844 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 930782000845 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 930782000846 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930782000847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782000848 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 930782000849 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 930782000850 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930782000851 FeS/SAM binding site; other site 930782000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 930782000853 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 930782000854 LXG domain of WXG superfamily; Region: LXG; pfam04740 930782000855 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 930782000856 putative FMN binding site [chemical binding]; other site 930782000857 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 930782000858 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930782000859 nudix motif; other site 930782000860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782000861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782000862 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930782000863 putative dimerization interface [polypeptide binding]; other site 930782000864 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930782000865 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 930782000866 active site 930782000867 FMN binding site [chemical binding]; other site 930782000868 substrate binding site [chemical binding]; other site 930782000869 putative catalytic residue [active] 930782000870 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 930782000871 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782000872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782000873 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 930782000874 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930782000875 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930782000876 shikimate binding site; other site 930782000877 NAD(P) binding site [chemical binding]; other site 930782000878 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 930782000879 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 930782000880 active site 930782000881 catalytic residue [active] 930782000882 dimer interface [polypeptide binding]; other site 930782000883 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782000884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782000885 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 930782000886 dimerization interface [polypeptide binding]; other site 930782000887 substrate binding pocket [chemical binding]; other site 930782000888 Predicted acyl esterases [General function prediction only]; Region: COG2936 930782000889 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 930782000890 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 930782000891 active site 930782000892 catalytic triad [active] 930782000893 oxyanion hole [active] 930782000894 EamA-like transporter family; Region: EamA; pfam00892 930782000895 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 930782000896 EamA-like transporter family; Region: EamA; pfam00892 930782000897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 930782000898 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930782000899 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930782000900 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930782000901 substrate binding site [chemical binding]; other site 930782000902 hexamer interface [polypeptide binding]; other site 930782000903 metal binding site [ion binding]; metal-binding site 930782000904 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 930782000905 catalytic residue [active] 930782000906 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782000907 PRD domain; Region: PRD; pfam00874 930782000908 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782000909 active site 930782000910 P-loop; other site 930782000911 phosphorylation site [posttranslational modification] 930782000912 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000913 active site 930782000914 phosphorylation site [posttranslational modification] 930782000915 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 930782000916 putative active site [active] 930782000917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782000918 active site 930782000919 phosphorylation site [posttranslational modification] 930782000920 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930782000921 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930782000922 substrate binding site [chemical binding]; other site 930782000923 hexamer interface [polypeptide binding]; other site 930782000924 metal binding site [ion binding]; metal-binding site 930782000925 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930782000926 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 930782000927 putative NAD(P) binding site [chemical binding]; other site 930782000928 catalytic Zn binding site [ion binding]; other site 930782000929 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 930782000930 active site 930782000931 P-loop; other site 930782000932 phosphorylation site [posttranslational modification] 930782000933 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930782000934 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930782000935 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 930782000936 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930782000937 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782000938 active site 930782000939 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930782000940 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 930782000941 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 930782000942 catalytic triad [active] 930782000943 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 930782000944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782000945 MarR family; Region: MarR_2; pfam12802 930782000946 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782000947 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782000948 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930782000949 Ligand Binding Site [chemical binding]; other site 930782000950 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 930782000951 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930782000952 putative active site [active] 930782000953 putative metal binding site [ion binding]; other site 930782000954 Transposase domain (DUF772); Region: DUF772; pfam05598 930782000955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930782000956 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 930782000957 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930782000958 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782000959 catalytic core [active] 930782000960 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782000961 Predicted membrane protein [Function unknown]; Region: COG3759 930782000962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782000963 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782000964 putative substrate translocation pore; other site 930782000965 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930782000966 non-specific DNA interactions [nucleotide binding]; other site 930782000967 DNA binding site [nucleotide binding] 930782000968 sequence specific DNA binding site [nucleotide binding]; other site 930782000969 putative cAMP binding site [chemical binding]; other site 930782000970 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782000971 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930782000972 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930782000973 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 930782000974 NAD binding site [chemical binding]; other site 930782000975 sugar binding site [chemical binding]; other site 930782000976 divalent metal binding site [ion binding]; other site 930782000977 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782000978 dimer interface [polypeptide binding]; other site 930782000979 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782000980 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782000981 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782000982 putative active site [active] 930782000983 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 930782000984 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930782000985 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930782000986 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930782000987 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 930782000988 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930782000989 DNA binding residues [nucleotide binding] 930782000990 dimer interface [polypeptide binding]; other site 930782000991 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 930782000992 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 930782000993 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 930782000994 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 930782000995 DXD motif; other site 930782000996 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 930782000997 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 930782000998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930782000999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782001000 S-adenosylmethionine binding site [chemical binding]; other site 930782001001 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 930782001002 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 930782001003 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782001004 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782001005 DNA binding site [nucleotide binding] 930782001006 domain linker motif; other site 930782001007 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930782001008 putative dimerization interface [polypeptide binding]; other site 930782001009 putative ligand binding site [chemical binding]; other site 930782001010 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 930782001011 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 930782001012 NAD binding site [chemical binding]; other site 930782001013 sugar binding site [chemical binding]; other site 930782001014 divalent metal binding site [ion binding]; other site 930782001015 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782001016 dimer interface [polypeptide binding]; other site 930782001017 allantoate amidohydrolase; Reviewed; Region: PRK09290 930782001018 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 930782001019 active site 930782001020 metal binding site [ion binding]; metal-binding site 930782001021 dimer interface [polypeptide binding]; other site 930782001022 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930782001023 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 930782001024 metal binding site [ion binding]; metal-binding site 930782001025 putative dimer interface [polypeptide binding]; other site 930782001026 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 930782001027 Beta-lactamase; Region: Beta-lactamase; pfam00144 930782001028 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930782001029 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930782001030 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930782001031 intersubunit interface [polypeptide binding]; other site 930782001032 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 930782001033 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 930782001034 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 930782001035 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 930782001036 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 930782001037 Glucitol operon activator protein (GutM); Region: GutM; cl01890 930782001038 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 930782001039 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782001040 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 930782001041 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930782001042 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930782001043 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782001044 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 930782001045 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782001046 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782001047 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782001048 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782001049 WxL domain surface cell wall-binding; Region: WxL; pfam13731 930782001050 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 930782001051 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 930782001052 FOG: CBS domain [General function prediction only]; Region: COG0517 930782001053 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 930782001054 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 930782001055 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 930782001056 dimer interface [polypeptide binding]; other site 930782001057 active site 930782001058 metal binding site [ion binding]; metal-binding site 930782001059 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 930782001060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001061 putative substrate translocation pore; other site 930782001062 POT family; Region: PTR2; pfam00854 930782001063 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782001064 catalytic core [active] 930782001065 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782001066 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782001067 catalytic core [active] 930782001068 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782001069 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 930782001070 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 930782001071 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930782001072 Cl binding site [ion binding]; other site 930782001073 oligomer interface [polypeptide binding]; other site 930782001074 glutamate dehydrogenase; Provisional; Region: PRK09414 930782001075 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 930782001076 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 930782001077 NAD(P) binding site [chemical binding]; other site 930782001078 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 930782001079 metal binding site [ion binding]; metal-binding site 930782001080 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 930782001081 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 930782001082 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 930782001083 substrate binding site [chemical binding]; other site 930782001084 glutamase interaction surface [polypeptide binding]; other site 930782001085 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 930782001086 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 930782001087 catalytic residues [active] 930782001088 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 930782001089 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 930782001090 putative active site [active] 930782001091 oxyanion strand; other site 930782001092 catalytic triad [active] 930782001093 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 930782001094 putative active site pocket [active] 930782001095 4-fold oligomerization interface [polypeptide binding]; other site 930782001096 metal binding residues [ion binding]; metal-binding site 930782001097 3-fold/trimer interface [polypeptide binding]; other site 930782001098 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 930782001099 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 930782001100 NAD binding site [chemical binding]; other site 930782001101 dimerization interface [polypeptide binding]; other site 930782001102 product binding site; other site 930782001103 substrate binding site [chemical binding]; other site 930782001104 zinc binding site [ion binding]; other site 930782001105 catalytic residues [active] 930782001106 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 930782001107 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 930782001108 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 930782001109 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930782001110 dimer interface [polypeptide binding]; other site 930782001111 motif 1; other site 930782001112 active site 930782001113 motif 2; other site 930782001114 motif 3; other site 930782001115 histidinol-phosphatase; Reviewed; Region: PRK08123 930782001116 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 930782001117 active site 930782001118 dimer interface [polypeptide binding]; other site 930782001119 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930782001120 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930782001121 DNA binding site [nucleotide binding] 930782001122 active site 930782001123 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 930782001124 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930782001125 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782001126 beta-galactosidase; Region: BGL; TIGR03356 930782001127 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782001128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782001129 DNA-binding site [nucleotide binding]; DNA binding site 930782001130 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930782001131 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001132 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001133 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 930782001134 Uncharacterized conserved protein [Function unknown]; Region: COG2966 930782001135 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 930782001136 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 930782001137 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 930782001138 Predicted esterase [General function prediction only]; Region: COG0400 930782001139 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 930782001140 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 930782001141 putative RNA binding site [nucleotide binding]; other site 930782001142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782001143 S-adenosylmethionine binding site [chemical binding]; other site 930782001144 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 930782001145 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782001146 Bacterial SH3 domain; Region: SH3_3; pfam08239 930782001147 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782001148 NlpC/P60 family; Region: NLPC_P60; pfam00877 930782001149 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 930782001150 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930782001151 ATP binding site [chemical binding]; other site 930782001152 putative Mg++ binding site [ion binding]; other site 930782001153 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930782001154 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 930782001155 nucleotide binding region [chemical binding]; other site 930782001156 ATP-binding site [chemical binding]; other site 930782001157 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930782001158 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930782001159 WxL domain surface cell wall-binding; Region: WxL; pfam13731 930782001160 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 930782001161 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 930782001162 UreD urease accessory protein; Region: UreD; cl00530 930782001163 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 930782001164 DNA photolyase; Region: DNA_photolyase; pfam00875 930782001165 Predicted membrane protein [Function unknown]; Region: COG4852 930782001166 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 930782001167 DAK2 domain; Region: Dak2; pfam02734 930782001168 EDD domain protein, DegV family; Region: DegV; TIGR00762 930782001169 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930782001170 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 930782001171 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 930782001172 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 930782001173 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 930782001174 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 930782001175 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930782001176 homodimer interface [polypeptide binding]; other site 930782001177 substrate-cofactor binding pocket; other site 930782001178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782001179 catalytic residue [active] 930782001180 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 930782001181 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782001182 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930782001183 ligand binding site [chemical binding]; other site 930782001184 flexible hinge region; other site 930782001185 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782001186 BioY family; Region: BioY; pfam02632 930782001187 Predicted transcriptional regulators [Transcription]; Region: COG1695 930782001188 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930782001189 Predicted membrane protein [Function unknown]; Region: COG4709 930782001190 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930782001191 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930782001192 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930782001193 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930782001194 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930782001195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782001196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930782001197 Coenzyme A binding pocket [chemical binding]; other site 930782001198 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 930782001199 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930782001200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930782001201 MarR family; Region: MarR_2; pfam12802 930782001202 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782001203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782001204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782001205 Walker A/P-loop; other site 930782001206 ATP binding site [chemical binding]; other site 930782001207 Q-loop/lid; other site 930782001208 ABC transporter signature motif; other site 930782001209 Walker B; other site 930782001210 D-loop; other site 930782001211 H-loop/switch region; other site 930782001212 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782001213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782001214 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930782001215 Walker A/P-loop; other site 930782001216 ATP binding site [chemical binding]; other site 930782001217 Q-loop/lid; other site 930782001218 ABC transporter signature motif; other site 930782001219 Walker B; other site 930782001220 D-loop; other site 930782001221 H-loop/switch region; other site 930782001222 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930782001223 active site residue [active] 930782001224 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782001225 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930782001226 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930782001227 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930782001228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782001229 putative DNA binding site [nucleotide binding]; other site 930782001230 putative Zn2+ binding site [ion binding]; other site 930782001231 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 930782001232 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 930782001233 putative NAD(P) binding site [chemical binding]; other site 930782001234 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930782001235 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930782001236 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 930782001237 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930782001238 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 930782001239 putative active site [active] 930782001240 catalytic site [active] 930782001241 putative metal binding site [ion binding]; other site 930782001242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 930782001243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930782001244 active site 930782001245 ATP binding site [chemical binding]; other site 930782001246 substrate binding site [chemical binding]; other site 930782001247 activation loop (A-loop); other site 930782001248 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 930782001249 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 930782001250 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930782001251 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930782001252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782001253 Coenzyme A binding pocket [chemical binding]; other site 930782001254 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 930782001255 active site 930782001256 catalytic triad [active] 930782001257 oxyanion hole [active] 930782001258 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930782001259 domain interaction interfaces [polypeptide binding]; other site 930782001260 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930782001261 domain interaction interfaces [polypeptide binding]; other site 930782001262 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930782001263 domain interaction interfaces [polypeptide binding]; other site 930782001264 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 930782001265 domain interaction interfaces [polypeptide binding]; other site 930782001266 Isochorismatase family; Region: Isochorismatase; pfam00857 930782001267 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 930782001268 catalytic triad [active] 930782001269 conserved cis-peptide bond; other site 930782001270 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782001271 PRD domain; Region: PRD; pfam00874 930782001272 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782001273 active site 930782001274 P-loop; other site 930782001275 phosphorylation site [posttranslational modification] 930782001276 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782001277 active site 930782001278 phosphorylation site [posttranslational modification] 930782001279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782001280 active site 930782001281 phosphorylation site [posttranslational modification] 930782001282 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 930782001283 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930782001284 active site 930782001285 P-loop; other site 930782001286 phosphorylation site [posttranslational modification] 930782001287 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 930782001288 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 930782001289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001290 motif II; other site 930782001291 Predicted transcriptional regulator [Transcription]; Region: COG1959 930782001292 Transcriptional regulator; Region: Rrf2; pfam02082 930782001293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782001294 S-adenosylmethionine binding site [chemical binding]; other site 930782001295 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 930782001296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782001297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782001298 active site 930782001299 catalytic tetrad [active] 930782001300 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 930782001301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782001302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001303 motif II; other site 930782001304 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 930782001305 catalytic residue [active] 930782001306 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930782001307 Sulfatase; Region: Sulfatase; pfam00884 930782001308 amino acid transporter; Region: 2A0306; TIGR00909 930782001309 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930782001310 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 930782001311 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 930782001312 putative metal binding site [ion binding]; other site 930782001313 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 930782001314 active site 930782001315 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930782001316 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930782001317 Cl binding site [ion binding]; other site 930782001318 oligomer interface [polypeptide binding]; other site 930782001319 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930782001320 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782001321 DNA-binding site [nucleotide binding]; DNA binding site 930782001322 Predicted membrane protein [Function unknown]; Region: COG1511 930782001323 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930782001324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001325 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930782001326 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782001327 DNA-binding site [nucleotide binding]; DNA binding site 930782001328 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930782001329 Predicted integral membrane protein [Function unknown]; Region: COG5523 930782001330 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930782001331 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 930782001332 active site 930782001333 metal binding site [ion binding]; metal-binding site 930782001334 Predicted membrane protein [Function unknown]; Region: COG2322 930782001335 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 930782001336 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930782001337 minor groove reading motif; other site 930782001338 helix-hairpin-helix signature motif; other site 930782001339 substrate binding pocket [chemical binding]; other site 930782001340 active site 930782001341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782001342 non-specific DNA binding site [nucleotide binding]; other site 930782001343 salt bridge; other site 930782001344 sequence-specific DNA binding site [nucleotide binding]; other site 930782001345 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930782001346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 930782001347 Transposase; Region: HTH_Tnp_1; cl17663 930782001348 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782001349 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001350 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001351 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 930782001352 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 930782001353 dimer interface [polypeptide binding]; other site 930782001354 substrate binding site [chemical binding]; other site 930782001355 ATP binding site [chemical binding]; other site 930782001356 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782001357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001358 active site 930782001359 motif I; other site 930782001360 motif II; other site 930782001361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001362 maltose O-acetyltransferase; Provisional; Region: PRK10092 930782001363 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 930782001364 active site 930782001365 substrate binding site [chemical binding]; other site 930782001366 trimer interface [polypeptide binding]; other site 930782001367 CoA binding site [chemical binding]; other site 930782001368 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 930782001369 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782001370 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 930782001371 Walker A/P-loop; other site 930782001372 ATP binding site [chemical binding]; other site 930782001373 Q-loop/lid; other site 930782001374 ABC transporter signature motif; other site 930782001375 Walker B; other site 930782001376 D-loop; other site 930782001377 H-loop/switch region; other site 930782001378 inner membrane transport permease; Provisional; Region: PRK15066 930782001379 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930782001380 oxidoreductase; Provisional; Region: PRK07985 930782001381 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930782001382 NAD(P) binding site [chemical binding]; other site 930782001383 active site 930782001384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 930782001385 Predicted membrane protein [Function unknown]; Region: COG3152 930782001386 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 930782001387 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 930782001388 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 930782001389 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 930782001390 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 930782001391 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 930782001392 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 930782001393 FHIPEP family; Region: FHIPEP; pfam00771 930782001394 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 930782001395 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930782001396 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 930782001397 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930782001398 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 930782001399 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 930782001400 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 930782001401 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 930782001402 flagellar motor protein MotA; Validated; Region: PRK08124 930782001403 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 930782001404 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 930782001405 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 930782001406 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 930782001407 ligand binding site [chemical binding]; other site 930782001408 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930782001409 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 930782001410 putative metal binding site; other site 930782001411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782001412 binding surface 930782001413 TPR motif; other site 930782001414 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 930782001415 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 930782001416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782001417 active site 930782001418 phosphorylation site [posttranslational modification] 930782001419 intermolecular recognition site; other site 930782001420 dimerization interface [polypeptide binding]; other site 930782001421 flagellin; Provisional; Region: PRK12805 930782001422 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930782001423 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 930782001424 Response regulator receiver domain; Region: Response_reg; pfam00072 930782001425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782001426 active site 930782001427 phosphorylation site [posttranslational modification] 930782001428 intermolecular recognition site; other site 930782001429 dimerization interface [polypeptide binding]; other site 930782001430 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 930782001431 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 930782001432 putative binding surface; other site 930782001433 active site 930782001434 P2 response regulator binding domain; Region: P2; pfam07194 930782001435 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 930782001436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782001437 ATP binding site [chemical binding]; other site 930782001438 Mg2+ binding site [ion binding]; other site 930782001439 G-X-G motif; other site 930782001440 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 930782001441 flagellar motor switch protein; Validated; Region: PRK06788 930782001442 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 930782001443 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 930782001444 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 930782001445 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 930782001446 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 930782001447 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 930782001448 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930782001449 flagellar motor switch protein; Validated; Region: PRK06789 930782001450 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 930782001451 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 930782001452 flagellar motor switch protein; Reviewed; Region: PRK06782 930782001453 CheC-like family; Region: CheC; pfam04509 930782001454 CheC-like family; Region: CheC; pfam04509 930782001455 Chemotaxis phosphatase CheX; Region: CheX; cl15816 930782001456 CheC-like family; Region: CheC; pfam04509 930782001457 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 930782001458 Protein of unknown function (DUF327); Region: DUF327; pfam03885 930782001459 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 930782001460 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930782001461 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 930782001462 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 930782001463 flagellar capping protein; Validated; Region: fliD; PRK06798 930782001464 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 930782001465 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 930782001466 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 930782001467 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 930782001468 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 930782001469 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 930782001470 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 930782001471 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 930782001472 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 930782001473 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 930782001474 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 930782001475 FliG C-terminal domain; Region: FliG_C; pfam01706 930782001476 flagellar assembly protein H; Validated; Region: fliH; PRK06800 930782001477 Flagellar assembly protein FliH; Region: FliH; pfam02108 930782001478 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 930782001479 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930782001480 Walker A motif; other site 930782001481 ATP binding site [chemical binding]; other site 930782001482 Walker B motif; other site 930782001483 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 930782001484 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930782001485 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930782001486 catalytic residue [active] 930782001487 Predicted transcriptional regulators [Transcription]; Region: COG1695 930782001488 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 930782001489 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 930782001490 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 930782001491 pyruvate oxidase; Provisional; Region: PRK08611 930782001492 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 930782001493 PYR/PP interface [polypeptide binding]; other site 930782001494 dimer interface [polypeptide binding]; other site 930782001495 tetramer interface [polypeptide binding]; other site 930782001496 TPP binding site [chemical binding]; other site 930782001497 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930782001498 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 930782001499 TPP-binding site [chemical binding]; other site 930782001500 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 930782001501 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930782001502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782001503 dimerization interface [polypeptide binding]; other site 930782001504 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930782001505 dimer interface [polypeptide binding]; other site 930782001506 putative CheW interface [polypeptide binding]; other site 930782001507 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930782001508 putative active site [active] 930782001509 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 930782001510 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 930782001511 glutaminase active site [active] 930782001512 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930782001513 dimer interface [polypeptide binding]; other site 930782001514 active site 930782001515 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930782001516 dimer interface [polypeptide binding]; other site 930782001517 active site 930782001518 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 930782001519 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930782001520 active site 930782001521 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 930782001522 GIY-YIG motif/motif A; other site 930782001523 Leucine rich repeat; Region: LRR_8; pfam13855 930782001524 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001525 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001526 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782001528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782001529 non-specific DNA binding site [nucleotide binding]; other site 930782001530 salt bridge; other site 930782001531 sequence-specific DNA binding site [nucleotide binding]; other site 930782001532 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782001533 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782001534 ligand binding site [chemical binding]; other site 930782001535 flexible hinge region; other site 930782001536 Predicted transcriptional regulators [Transcription]; Region: COG1725 930782001537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782001538 DNA-binding site [nucleotide binding]; DNA binding site 930782001539 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930782001540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782001541 Walker A/P-loop; other site 930782001542 ATP binding site [chemical binding]; other site 930782001543 Q-loop/lid; other site 930782001544 ABC transporter signature motif; other site 930782001545 Walker B; other site 930782001546 D-loop; other site 930782001547 H-loop/switch region; other site 930782001548 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782001549 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782001550 Walker A/P-loop; other site 930782001551 ATP binding site [chemical binding]; other site 930782001552 Q-loop/lid; other site 930782001553 ABC transporter signature motif; other site 930782001554 Walker B; other site 930782001555 D-loop; other site 930782001556 H-loop/switch region; other site 930782001557 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782001558 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782001559 FtsX-like permease family; Region: FtsX; pfam02687 930782001560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930782001561 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782001562 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930782001563 ligand binding site [chemical binding]; other site 930782001564 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930782001565 non-specific DNA interactions [nucleotide binding]; other site 930782001566 DNA binding site [nucleotide binding] 930782001567 sequence specific DNA binding site [nucleotide binding]; other site 930782001568 putative cAMP binding site [chemical binding]; other site 930782001569 SnoaL-like domain; Region: SnoaL_4; pfam13577 930782001570 Transposase domain (DUF772); Region: DUF772; pfam05598 930782001571 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930782001572 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 930782001573 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930782001574 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 930782001575 active site 930782001576 catalytic triad [active] 930782001577 oxyanion hole [active] 930782001578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782001579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782001580 Walker A/P-loop; other site 930782001581 ATP binding site [chemical binding]; other site 930782001582 Q-loop/lid; other site 930782001583 ABC transporter signature motif; other site 930782001584 Walker B; other site 930782001585 D-loop; other site 930782001586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930782001587 H-loop/switch region; other site 930782001588 active site 930782001589 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 930782001590 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930782001591 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930782001592 Zn binding site [ion binding]; other site 930782001593 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930782001594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782001595 Zn binding site [ion binding]; other site 930782001596 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 930782001597 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782001598 Zn binding site [ion binding]; other site 930782001599 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 930782001600 Zn binding site [ion binding]; other site 930782001601 Predicted esterase [General function prediction only]; Region: COG0400 930782001602 putative hydrolase; Provisional; Region: PRK11460 930782001603 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 930782001604 GTPases [General function prediction only]; Region: HflX; COG2262 930782001605 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930782001606 HflX GTPase family; Region: HflX; cd01878 930782001607 G1 box; other site 930782001608 GTP/Mg2+ binding site [chemical binding]; other site 930782001609 Switch I region; other site 930782001610 G2 box; other site 930782001611 G3 box; other site 930782001612 Switch II region; other site 930782001613 G4 box; other site 930782001614 G5 box; other site 930782001615 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930782001616 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930782001617 putative active site [active] 930782001618 putative metal binding site [ion binding]; other site 930782001619 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 930782001620 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930782001621 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 930782001622 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930782001623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782001624 DNA-binding site [nucleotide binding]; DNA binding site 930782001625 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 930782001626 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 930782001627 putative NADP binding site [chemical binding]; other site 930782001628 putative dimer interface [polypeptide binding]; other site 930782001629 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 930782001630 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930782001631 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782001632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782001633 nucleotide binding site [chemical binding]; other site 930782001634 Predicted membrane protein [Function unknown]; Region: COG4811 930782001635 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 930782001636 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 930782001637 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930782001638 active site 930782001639 phosphorylation site [posttranslational modification] 930782001640 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782001641 active pocket/dimerization site; other site 930782001642 active site 930782001643 phosphorylation site [posttranslational modification] 930782001644 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 930782001645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782001646 Walker A motif; other site 930782001647 ATP binding site [chemical binding]; other site 930782001648 Walker B motif; other site 930782001649 arginine finger; other site 930782001650 Transcriptional antiterminator [Transcription]; Region: COG3933 930782001651 PRD domain; Region: PRD; pfam00874 930782001652 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782001653 active pocket/dimerization site; other site 930782001654 active site 930782001655 phosphorylation site [posttranslational modification] 930782001656 PRD domain; Region: PRD; pfam00874 930782001657 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 930782001658 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930782001659 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 930782001660 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 930782001661 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 930782001662 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 930782001663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 930782001664 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 930782001665 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 930782001666 Leucine rich repeat; Region: LRR_8; pfam13855 930782001667 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001668 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001669 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001670 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001671 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001672 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782001673 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 930782001674 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930782001675 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 930782001676 putative deacylase active site [active] 930782001677 Predicted amidohydrolase [General function prediction only]; Region: COG0388 930782001678 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 930782001679 active site 930782001680 catalytic triad [active] 930782001681 dimer interface [polypeptide binding]; other site 930782001682 Protein of unknown function (DUF554); Region: DUF554; pfam04474 930782001683 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 930782001684 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930782001685 NAD binding site [chemical binding]; other site 930782001686 substrate binding site [chemical binding]; other site 930782001687 putative active site [active] 930782001688 Predicted permeases [General function prediction only]; Region: RarD; COG2962 930782001689 EamA-like transporter family; Region: EamA; pfam00892 930782001690 Uncharacterized conserved protein [Function unknown]; Region: COG2353 930782001691 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930782001692 MarR family; Region: MarR_2; pfam12802 930782001693 lysine transporter; Provisional; Region: PRK10836 930782001694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930782001695 PAS domain; Region: PAS_9; pfam13426 930782001696 putative active site [active] 930782001697 heme pocket [chemical binding]; other site 930782001698 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782001699 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 930782001700 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930782001701 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930782001702 synthetase active site [active] 930782001703 NTP binding site [chemical binding]; other site 930782001704 metal binding site [ion binding]; metal-binding site 930782001705 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930782001706 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 930782001707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782001708 non-specific DNA binding site [nucleotide binding]; other site 930782001709 salt bridge; other site 930782001710 sequence-specific DNA binding site [nucleotide binding]; other site 930782001711 Cupin domain; Region: Cupin_2; pfam07883 930782001712 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 930782001713 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 930782001714 Walker A/P-loop; other site 930782001715 ATP binding site [chemical binding]; other site 930782001716 Q-loop/lid; other site 930782001717 ABC transporter signature motif; other site 930782001718 Walker B; other site 930782001719 D-loop; other site 930782001720 H-loop/switch region; other site 930782001721 TOBE domain; Region: TOBE_2; pfam08402 930782001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930782001723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782001724 putative PBP binding loops; other site 930782001725 ABC-ATPase subunit interface; other site 930782001726 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930782001727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782001728 dimer interface [polypeptide binding]; other site 930782001729 conserved gate region; other site 930782001730 putative PBP binding loops; other site 930782001731 ABC-ATPase subunit interface; other site 930782001732 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 930782001733 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 930782001734 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 930782001735 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 930782001736 active site 930782001737 zinc binding site [ion binding]; other site 930782001738 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930782001739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782001740 Zn2+ binding site [ion binding]; other site 930782001741 Mg2+ binding site [ion binding]; other site 930782001742 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782001743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782001744 nucleotide binding site [chemical binding]; other site 930782001745 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 930782001746 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930782001747 FMN binding site [chemical binding]; other site 930782001748 substrate binding site [chemical binding]; other site 930782001749 putative catalytic residue [active] 930782001750 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 930782001751 LXG domain of WXG superfamily; Region: LXG; pfam04740 930782001752 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930782001753 dimer interface [polypeptide binding]; other site 930782001754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782001755 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 930782001756 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930782001757 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782001758 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930782001759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001760 motif II; other site 930782001761 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930782001762 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782001763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782001764 Coenzyme A binding pocket [chemical binding]; other site 930782001765 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 930782001766 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782001767 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782001768 DNA binding residues [nucleotide binding] 930782001769 putative dimer interface [polypeptide binding]; other site 930782001770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782001771 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782001772 active site 930782001773 catalytic tetrad [active] 930782001774 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930782001775 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 930782001776 homodimer interface [polypeptide binding]; other site 930782001777 catalytic residues [active] 930782001778 NAD binding site [chemical binding]; other site 930782001779 substrate binding pocket [chemical binding]; other site 930782001780 flexible flap; other site 930782001781 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 930782001782 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930782001783 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 930782001784 PhoU domain; Region: PhoU; pfam01895 930782001785 PhoU domain; Region: PhoU; pfam01895 930782001786 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 930782001787 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 930782001788 dimer interface [polypeptide binding]; other site 930782001789 PYR/PP interface [polypeptide binding]; other site 930782001790 TPP binding site [chemical binding]; other site 930782001791 substrate binding site [chemical binding]; other site 930782001792 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 930782001793 Domain of unknown function; Region: EKR; smart00890 930782001794 4Fe-4S binding domain; Region: Fer4_6; pfam12837 930782001795 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 930782001796 TPP-binding site [chemical binding]; other site 930782001797 dimer interface [polypeptide binding]; other site 930782001798 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 930782001799 Predicted permeases [General function prediction only]; Region: COG0679 930782001800 Helix-turn-helix domain; Region: HTH_28; pfam13518 930782001801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782001802 non-specific DNA binding site [nucleotide binding]; other site 930782001803 salt bridge; other site 930782001804 sequence-specific DNA binding site [nucleotide binding]; other site 930782001805 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930782001806 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001807 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782001808 Predicted membrane protein [Function unknown]; Region: COG3223 930782001809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782001810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782001811 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930782001812 Walker A/P-loop; other site 930782001813 ATP binding site [chemical binding]; other site 930782001814 Q-loop/lid; other site 930782001815 ABC transporter signature motif; other site 930782001816 Walker B; other site 930782001817 D-loop; other site 930782001818 H-loop/switch region; other site 930782001819 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 930782001820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001821 putative substrate translocation pore; other site 930782001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001823 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782001825 putative substrate translocation pore; other site 930782001826 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782001827 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782001828 putative DNA binding site [nucleotide binding]; other site 930782001829 putative Zn2+ binding site [ion binding]; other site 930782001830 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930782001831 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 930782001832 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782001833 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930782001834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782001835 motif II; other site 930782001836 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930782001837 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001838 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001839 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001840 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001841 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001842 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001843 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 930782001844 Predicted membrane protein [Function unknown]; Region: COG3326 930782001845 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 930782001846 homotrimer interaction site [polypeptide binding]; other site 930782001847 putative active site [active] 930782001848 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930782001849 substrate binding site [chemical binding]; other site 930782001850 zinc-binding site [ion binding]; other site 930782001851 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930782001852 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930782001853 GIY-YIG motif/motif A; other site 930782001854 active site 930782001855 catalytic site [active] 930782001856 putative DNA binding site [nucleotide binding]; other site 930782001857 metal binding site [ion binding]; metal-binding site 930782001858 UvrB/uvrC motif; Region: UVR; pfam02151 930782001859 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930782001860 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930782001861 substrate binding pocket [chemical binding]; other site 930782001862 membrane-bound complex binding site; other site 930782001863 hinge residues; other site 930782001864 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930782001865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782001866 dimer interface [polypeptide binding]; other site 930782001867 conserved gate region; other site 930782001868 putative PBP binding loops; other site 930782001869 ABC-ATPase subunit interface; other site 930782001870 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930782001871 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930782001872 Walker A/P-loop; other site 930782001873 ATP binding site [chemical binding]; other site 930782001874 Q-loop/lid; other site 930782001875 ABC transporter signature motif; other site 930782001876 Walker B; other site 930782001877 D-loop; other site 930782001878 H-loop/switch region; other site 930782001879 amidase; Provisional; Region: PRK11910 930782001880 Amidase; Region: Amidase; cl11426 930782001881 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782001882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782001883 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930782001884 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 930782001885 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 930782001886 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 930782001887 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 930782001888 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 930782001889 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930782001890 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930782001891 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 930782001892 Esterase/lipase [General function prediction only]; Region: COG1647 930782001893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782001894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782001895 DNA binding site [nucleotide binding] 930782001896 domain linker motif; other site 930782001897 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 930782001898 putative dimerization interface [polypeptide binding]; other site 930782001899 putative ligand binding site [chemical binding]; other site 930782001900 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930782001901 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782001902 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 930782001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782001904 dimer interface [polypeptide binding]; other site 930782001905 conserved gate region; other site 930782001906 putative PBP binding loops; other site 930782001907 ABC-ATPase subunit interface; other site 930782001908 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782001910 dimer interface [polypeptide binding]; other site 930782001911 conserved gate region; other site 930782001912 ABC-ATPase subunit interface; other site 930782001913 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930782001914 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930782001915 Ca binding site [ion binding]; other site 930782001916 active site 930782001917 catalytic site [active] 930782001918 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 930782001919 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 930782001920 active site 930782001921 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930782001922 active site 930782001923 substrate binding site [chemical binding]; other site 930782001924 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 930782001925 metal binding site [ion binding]; metal-binding site 930782001926 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930782001927 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782001928 ATP binding site [chemical binding]; other site 930782001929 Mg++ binding site [ion binding]; other site 930782001930 motif III; other site 930782001931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782001932 nucleotide binding region [chemical binding]; other site 930782001933 ATP-binding site [chemical binding]; other site 930782001934 Predicted membrane protein [Function unknown]; Region: COG4708 930782001935 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 930782001936 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 930782001937 Predicted transcriptional regulators [Transcription]; Region: COG1733 930782001938 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930782001939 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 930782001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782001941 putative substrate translocation pore; other site 930782001942 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782001943 PRD domain; Region: PRD; pfam00874 930782001944 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782001945 active site 930782001946 P-loop; other site 930782001947 phosphorylation site [posttranslational modification] 930782001948 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782001949 active site 930782001950 phosphorylation site [posttranslational modification] 930782001951 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782001952 methionine cluster; other site 930782001953 active site 930782001954 phosphorylation site [posttranslational modification] 930782001955 metal binding site [ion binding]; metal-binding site 930782001956 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782001957 active site 930782001958 P-loop; other site 930782001959 phosphorylation site [posttranslational modification] 930782001960 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782001961 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782001962 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930782001963 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930782001964 active site 930782001965 trimer interface [polypeptide binding]; other site 930782001966 allosteric site; other site 930782001967 active site lid [active] 930782001968 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930782001969 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782001970 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782001971 active site 930782001972 catalytic tetrad [active] 930782001973 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930782001974 Collagen binding domain; Region: Collagen_bind; pfam05737 930782001975 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782001976 Uncharacterized conserved protein [Function unknown]; Region: COG3402 930782001977 Predicted membrane protein [Function unknown]; Region: COG3428 930782001978 Bacterial PH domain; Region: DUF304; pfam03703 930782001979 Bacterial PH domain; Region: DUF304; pfam03703 930782001980 Bacterial PH domain; Region: DUF304; pfam03703 930782001981 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 930782001982 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 930782001983 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 930782001984 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 930782001985 active site 930782001986 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930782001987 dimer interface [polypeptide binding]; other site 930782001988 substrate binding site [chemical binding]; other site 930782001989 catalytic residues [active] 930782001990 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 930782001991 PemK-like protein; Region: PemK; pfam02452 930782001992 Rsbr N terminal; Region: Rsbr_N; pfam08678 930782001993 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782001994 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782001995 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930782001996 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 930782001997 ATP binding site [chemical binding]; other site 930782001998 Mg2+ binding site [ion binding]; other site 930782001999 G-X-G motif; other site 930782002000 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 930782002001 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 930782002002 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 930782002003 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 930782002004 anti sigma factor interaction site; other site 930782002005 regulatory phosphorylation site [posttranslational modification]; other site 930782002006 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 930782002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782002008 ATP binding site [chemical binding]; other site 930782002009 Mg2+ binding site [ion binding]; other site 930782002010 G-X-G motif; other site 930782002011 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 930782002012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930782002013 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930782002014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930782002015 DNA binding residues [nucleotide binding] 930782002016 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 930782002017 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 930782002018 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 930782002019 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930782002020 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 930782002021 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 930782002022 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 930782002023 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 930782002024 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 930782002025 RNA binding site [nucleotide binding]; other site 930782002026 hypothetical protein; Provisional; Region: PRK04351 930782002027 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 930782002028 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 930782002029 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 930782002030 Uncharacterized conserved protein [Function unknown]; Region: COG5646 930782002031 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782002032 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782002033 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782002034 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782002035 DNA-binding site [nucleotide binding]; DNA binding site 930782002036 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930782002037 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 930782002038 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930782002039 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 930782002040 glutathione reductase; Validated; Region: PRK06116 930782002041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782002042 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782002043 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930782002044 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782002045 catalytic core [active] 930782002046 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930782002047 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930782002048 Predicted transcriptional regulators [Transcription]; Region: COG1725 930782002049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782002050 DNA-binding site [nucleotide binding]; DNA binding site 930782002051 Predicted membrane protein [General function prediction only]; Region: COG4194 930782002052 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930782002053 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930782002054 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 930782002055 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 930782002056 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 930782002057 tetramerization interface [polypeptide binding]; other site 930782002058 NAD(P) binding site [chemical binding]; other site 930782002059 catalytic residues [active] 930782002060 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 930782002061 active site 930782002062 P-loop; other site 930782002063 phosphorylation site [posttranslational modification] 930782002064 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782002065 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782002066 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782002067 methionine cluster; other site 930782002068 active site 930782002069 phosphorylation site [posttranslational modification] 930782002070 metal binding site [ion binding]; metal-binding site 930782002071 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782002072 beta-galactosidase; Region: BGL; TIGR03356 930782002073 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782002074 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782002075 PRD domain; Region: PRD; pfam00874 930782002076 PRD domain; Region: PRD; pfam00874 930782002077 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782002078 active site 930782002079 phosphorylation site [posttranslational modification] 930782002080 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782002081 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930782002082 ABC transporter; Region: ABC_tran_2; pfam12848 930782002083 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782002084 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 930782002085 Predicted permeases [General function prediction only]; Region: COG0701 930782002086 Predicted membrane protein [Function unknown]; Region: COG3689 930782002087 pantothenate kinase; Provisional; Region: PRK05439 930782002088 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 930782002089 ATP-binding site [chemical binding]; other site 930782002090 CoA-binding site [chemical binding]; other site 930782002091 Mg2+-binding site [ion binding]; other site 930782002092 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 930782002093 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782002094 Walker A/P-loop; other site 930782002095 ATP binding site [chemical binding]; other site 930782002096 Q-loop/lid; other site 930782002097 ABC transporter signature motif; other site 930782002098 Walker B; other site 930782002099 D-loop; other site 930782002100 H-loop/switch region; other site 930782002101 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930782002102 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930782002103 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782002104 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782002105 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 930782002106 Domain of unknown function (DUF373); Region: DUF373; cl12079 930782002107 Sulfatase; Region: Sulfatase; pfam00884 930782002108 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 930782002109 active site 930782002110 DNA binding site [nucleotide binding] 930782002111 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 930782002112 active site 930782002113 catalytic site [active] 930782002114 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 930782002115 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930782002116 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 930782002117 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 930782002118 Uncharacterized conserved protein [Function unknown]; Region: COG0398 930782002119 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930782002120 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 930782002121 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 930782002122 epoxyqueuosine reductase; Region: TIGR00276 930782002123 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 930782002124 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 930782002125 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930782002126 dimer interface [polypeptide binding]; other site 930782002127 FMN binding site [chemical binding]; other site 930782002128 NADPH bind site [chemical binding]; other site 930782002129 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930782002130 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930782002131 active site 930782002132 HSP90 family protein; Provisional; Region: PRK14083 930782002133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782002134 ATP binding site [chemical binding]; other site 930782002135 Mg2+ binding site [ion binding]; other site 930782002136 G-X-G motif; other site 930782002137 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 930782002138 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 930782002139 dimerization interface [polypeptide binding]; other site 930782002140 DPS ferroxidase diiron center [ion binding]; other site 930782002141 ion pore; other site 930782002142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 930782002143 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 930782002144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782002145 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 930782002146 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 930782002147 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 930782002148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782002149 putative substrate translocation pore; other site 930782002150 Transcriptional regulators [Transcription]; Region: FadR; COG2186 930782002151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782002152 DNA-binding site [nucleotide binding]; DNA binding site 930782002153 FCD domain; Region: FCD; pfam07729 930782002154 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 930782002155 PGAP1-like protein; Region: PGAP1; pfam07819 930782002156 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 930782002157 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 930782002158 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 930782002159 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 930782002160 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930782002161 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930782002162 active site 930782002163 dimer interface [polypeptide binding]; other site 930782002164 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930782002165 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930782002166 active site 930782002167 trimer interface [polypeptide binding]; other site 930782002168 allosteric site; other site 930782002169 active site lid [active] 930782002170 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930782002171 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782002172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782002173 DNA-binding site [nucleotide binding]; DNA binding site 930782002174 UTRA domain; Region: UTRA; pfam07702 930782002175 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930782002176 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930782002177 Mg++ binding site [ion binding]; other site 930782002178 putative catalytic motif [active] 930782002179 substrate binding site [chemical binding]; other site 930782002180 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930782002181 Peptidase family U32; Region: Peptidase_U32; pfam01136 930782002182 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930782002183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930782002184 Peptidase family U32; Region: Peptidase_U32; pfam01136 930782002185 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 930782002186 heat shock protein HtpX; Provisional; Region: PRK04897 930782002187 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 930782002188 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 930782002189 catalytic residues [active] 930782002190 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 930782002191 putative active site [active] 930782002192 putative metal binding residues [ion binding]; other site 930782002193 signature motif; other site 930782002194 putative triphosphate binding site [ion binding]; other site 930782002195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782002196 TPR motif; other site 930782002197 binding surface 930782002198 Tetratrico peptide repeat; Region: TPR_5; pfam12688 930782002199 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930782002200 synthetase active site [active] 930782002201 NTP binding site [chemical binding]; other site 930782002202 metal binding site [ion binding]; metal-binding site 930782002203 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 930782002204 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930782002205 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930782002206 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930782002207 active site 930782002208 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 930782002209 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 930782002210 NAD binding site [chemical binding]; other site 930782002211 homotetramer interface [polypeptide binding]; other site 930782002212 homodimer interface [polypeptide binding]; other site 930782002213 substrate binding site [chemical binding]; other site 930782002214 active site 930782002215 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 930782002216 DltD N-terminal region; Region: DltD_N; pfam04915 930782002217 DltD central region; Region: DltD_M; pfam04918 930782002218 DltD C-terminal region; Region: DltD_C; pfam04914 930782002219 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 930782002220 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 930782002221 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 930782002222 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 930782002223 acyl-activating enzyme (AAE) consensus motif; other site 930782002224 AMP binding site [chemical binding]; other site 930782002225 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 930782002226 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 930782002227 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782002228 active site 930782002229 dimer interface [polypeptide binding]; other site 930782002230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782002231 Coenzyme A binding pocket [chemical binding]; other site 930782002232 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 930782002233 Putative esterase; Region: Esterase; pfam00756 930782002234 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 930782002235 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 930782002236 homodimer interface [polypeptide binding]; other site 930782002237 substrate-cofactor binding pocket; other site 930782002238 catalytic residue [active] 930782002239 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930782002240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782002241 Walker A/P-loop; other site 930782002242 ATP binding site [chemical binding]; other site 930782002243 Q-loop/lid; other site 930782002244 ABC transporter signature motif; other site 930782002245 Walker B; other site 930782002246 D-loop; other site 930782002247 H-loop/switch region; other site 930782002248 ABC-2 type transporter; Region: ABC2_membrane; cl17235 930782002249 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930782002250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782002251 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782002252 putative substrate translocation pore; other site 930782002253 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930782002254 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 930782002255 putative oligomer interface [polypeptide binding]; other site 930782002256 putative active site [active] 930782002257 metal binding site [ion binding]; metal-binding site 930782002258 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 930782002259 catalytic residues [active] 930782002260 dimer interface [polypeptide binding]; other site 930782002261 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930782002262 LytTr DNA-binding domain; Region: LytTR; pfam04397 930782002263 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782002264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782002265 Walker A/P-loop; other site 930782002266 ATP binding site [chemical binding]; other site 930782002267 Q-loop/lid; other site 930782002268 ABC transporter signature motif; other site 930782002269 Walker B; other site 930782002270 D-loop; other site 930782002271 H-loop/switch region; other site 930782002272 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 930782002273 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 930782002274 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930782002275 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 930782002276 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 930782002277 G1 box; other site 930782002278 putative GEF interaction site [polypeptide binding]; other site 930782002279 GTP/Mg2+ binding site [chemical binding]; other site 930782002280 Switch I region; other site 930782002281 G2 box; other site 930782002282 G3 box; other site 930782002283 Switch II region; other site 930782002284 G4 box; other site 930782002285 G5 box; other site 930782002286 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 930782002287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782002288 MarR family; Region: MarR_2; cl17246 930782002289 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930782002290 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930782002291 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930782002292 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 930782002293 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 930782002294 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 930782002295 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 930782002296 Acyltransferase family; Region: Acyl_transf_3; pfam01757 930782002297 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 930782002298 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930782002299 DNA binding site [nucleotide binding] 930782002300 active site 930782002301 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 930782002302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782002303 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 930782002304 Walker A motif; other site 930782002305 ATP binding site [chemical binding]; other site 930782002306 Walker B motif; other site 930782002307 arginine finger; other site 930782002308 UvrB/uvrC motif; Region: UVR; pfam02151 930782002309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782002310 Walker A motif; other site 930782002311 ATP binding site [chemical binding]; other site 930782002312 Walker B motif; other site 930782002313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930782002314 CAAX protease self-immunity; Region: Abi; pfam02517 930782002315 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 930782002316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930782002317 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 930782002318 nucleotide binding site [chemical binding]; other site 930782002319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 930782002320 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 930782002321 dimerization domain swap beta strand [polypeptide binding]; other site 930782002322 regulatory protein interface [polypeptide binding]; other site 930782002323 active site 930782002324 regulatory phosphorylation site [posttranslational modification]; other site 930782002325 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 930782002326 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 930782002327 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930782002328 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930782002329 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930782002330 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930782002331 putative active site [active] 930782002332 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 930782002333 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930782002334 aminotransferase A; Validated; Region: PRK07683 930782002335 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782002336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782002337 homodimer interface [polypeptide binding]; other site 930782002338 catalytic residue [active] 930782002339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 930782002340 FOG: CBS domain [General function prediction only]; Region: COG0517 930782002341 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 930782002342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782002343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782002344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930782002345 dimerization interface [polypeptide binding]; other site 930782002346 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 930782002347 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 930782002348 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930782002349 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930782002350 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930782002351 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 930782002352 metal binding site [ion binding]; metal-binding site 930782002353 putative dimer interface [polypeptide binding]; other site 930782002354 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 930782002355 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 930782002356 Mechanosensitive ion channel; Region: MS_channel; pfam00924 930782002357 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 930782002358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782002359 Walker A/P-loop; other site 930782002360 ATP binding site [chemical binding]; other site 930782002361 Q-loop/lid; other site 930782002362 ABC transporter signature motif; other site 930782002363 Walker B; other site 930782002364 D-loop; other site 930782002365 H-loop/switch region; other site 930782002366 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 930782002367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782002368 dimer interface [polypeptide binding]; other site 930782002369 conserved gate region; other site 930782002370 putative PBP binding loops; other site 930782002371 ABC-ATPase subunit interface; other site 930782002372 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 930782002373 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930782002374 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930782002375 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 930782002376 HPr interaction site; other site 930782002377 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930782002378 active site 930782002379 phosphorylation site [posttranslational modification] 930782002380 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 930782002381 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 930782002382 S1 domain; Region: S1_2; pfam13509 930782002383 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 930782002384 RNA binding site [nucleotide binding]; other site 930782002385 Predicted membrane protein [Function unknown]; Region: COG4758 930782002386 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 930782002387 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 930782002388 Histidine kinase; Region: HisKA_3; pfam07730 930782002389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782002390 ATP binding site [chemical binding]; other site 930782002391 Mg2+ binding site [ion binding]; other site 930782002392 G-X-G motif; other site 930782002393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930782002394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782002395 active site 930782002396 phosphorylation site [posttranslational modification] 930782002397 intermolecular recognition site; other site 930782002398 dimerization interface [polypeptide binding]; other site 930782002399 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930782002400 DNA binding residues [nucleotide binding] 930782002401 dimerization interface [polypeptide binding]; other site 930782002402 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 930782002403 TrkA-N domain; Region: TrkA_N; pfam02254 930782002404 TrkA-C domain; Region: TrkA_C; pfam02080 930782002405 Predicted membrane protein [Function unknown]; Region: COG1289 930782002406 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 930782002407 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 930782002408 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930782002409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930782002410 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930782002411 hypothetical protein; Provisional; Region: PRK13667 930782002412 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782002413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782002414 active site 930782002415 motif I; other site 930782002416 motif II; other site 930782002417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782002418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782002419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782002420 DNA binding site [nucleotide binding] 930782002421 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930782002422 ligand binding site [chemical binding]; other site 930782002423 dimerization interface [polypeptide binding]; other site 930782002424 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 930782002425 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930782002426 trimer interface [polypeptide binding]; other site 930782002427 substrate binding site [chemical binding]; other site 930782002428 Mn binding site [ion binding]; other site 930782002429 transketolase; Reviewed; Region: PRK05899 930782002430 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930782002431 TPP-binding site [chemical binding]; other site 930782002432 dimer interface [polypeptide binding]; other site 930782002433 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 930782002434 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930782002435 PYR/PP interface [polypeptide binding]; other site 930782002436 dimer interface [polypeptide binding]; other site 930782002437 TPP binding site [chemical binding]; other site 930782002438 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782002439 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 930782002440 Uncharacterized subgroup; belongs to the glycerol kinases subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GK_1; cd10427 930782002441 N- and C-terminal domain interface [polypeptide binding]; other site 930782002442 active site 930782002443 MgATP binding site [chemical binding]; other site 930782002444 catalytic site [active] 930782002445 metal binding site [ion binding]; metal-binding site 930782002446 putative glycerol binding site [chemical binding]; other site 930782002447 putative homotetramer interface [polypeptide binding]; other site 930782002448 putative homodimer interface [polypeptide binding]; other site 930782002449 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 930782002450 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930782002451 active site turn [active] 930782002452 phosphorylation site [posttranslational modification] 930782002453 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930782002454 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930782002455 HPr interaction site; other site 930782002456 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930782002457 active site 930782002458 phosphorylation site [posttranslational modification] 930782002459 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 930782002460 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 930782002461 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 930782002462 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 930782002463 GTP binding site; other site 930782002464 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 930782002465 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930782002466 Walker A/P-loop; other site 930782002467 ATP binding site [chemical binding]; other site 930782002468 Q-loop/lid; other site 930782002469 ABC transporter signature motif; other site 930782002470 Walker B; other site 930782002471 D-loop; other site 930782002472 H-loop/switch region; other site 930782002473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782002474 dimer interface [polypeptide binding]; other site 930782002475 conserved gate region; other site 930782002476 putative PBP binding loops; other site 930782002477 ABC-ATPase subunit interface; other site 930782002478 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 930782002479 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 930782002480 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 930782002481 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 930782002482 dimer interface [polypeptide binding]; other site 930782002483 putative functional site; other site 930782002484 putative MPT binding site; other site 930782002485 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 930782002486 Walker A motif; other site 930782002487 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 930782002488 MoaE homodimer interface [polypeptide binding]; other site 930782002489 MoaD interaction [polypeptide binding]; other site 930782002490 active site residues [active] 930782002491 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 930782002492 MoaE interaction surface [polypeptide binding]; other site 930782002493 MoeB interaction surface [polypeptide binding]; other site 930782002494 thiocarboxylated glycine; other site 930782002495 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 930782002496 trimer interface [polypeptide binding]; other site 930782002497 dimer interface [polypeptide binding]; other site 930782002498 putative active site [active] 930782002499 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 930782002500 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930782002501 FeS/SAM binding site; other site 930782002502 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 930782002503 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 930782002504 MPT binding site; other site 930782002505 trimer interface [polypeptide binding]; other site 930782002506 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 930782002507 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 930782002508 ATP binding site [chemical binding]; other site 930782002509 substrate interface [chemical binding]; other site 930782002510 Flavin Reductases; Region: FlaRed; cl00801 930782002511 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 930782002512 active site 930782002513 catalytic residues [active] 930782002514 metal binding site [ion binding]; metal-binding site 930782002515 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 930782002516 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930782002517 TPP-binding site [chemical binding]; other site 930782002518 tetramer interface [polypeptide binding]; other site 930782002519 heterodimer interface [polypeptide binding]; other site 930782002520 phosphorylation loop region [posttranslational modification] 930782002521 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930782002522 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930782002523 alpha subunit interface [polypeptide binding]; other site 930782002524 TPP binding site [chemical binding]; other site 930782002525 heterodimer interface [polypeptide binding]; other site 930782002526 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782002527 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 930782002528 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930782002529 E3 interaction surface; other site 930782002530 lipoyl attachment site [posttranslational modification]; other site 930782002531 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930782002532 E3 interaction surface; other site 930782002533 lipoyl attachment site [posttranslational modification]; other site 930782002534 e3 binding domain; Region: E3_binding; pfam02817 930782002535 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930782002536 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 930782002537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930782002538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782002539 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930782002540 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 930782002541 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 930782002542 NAD(P) binding site [chemical binding]; other site 930782002543 LDH/MDH dimer interface [polypeptide binding]; other site 930782002544 substrate binding site [chemical binding]; other site 930782002545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 930782002546 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 930782002547 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 930782002548 catalytic residues [active] 930782002549 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 930782002550 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 930782002551 Cl binding site [ion binding]; other site 930782002552 oligomer interface [polypeptide binding]; other site 930782002553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 930782002554 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 930782002555 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 930782002556 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 930782002557 active site 930782002558 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 930782002559 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 930782002560 G1 box; other site 930782002561 putative GEF interaction site [polypeptide binding]; other site 930782002562 GTP/Mg2+ binding site [chemical binding]; other site 930782002563 Switch I region; other site 930782002564 G2 box; other site 930782002565 G3 box; other site 930782002566 Switch II region; other site 930782002567 G4 box; other site 930782002568 G5 box; other site 930782002569 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 930782002570 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 930782002571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 930782002572 hypothetical protein; Provisional; Region: PRK13666 930782002573 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930782002574 pyruvate carboxylase; Reviewed; Region: PRK12999 930782002575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930782002576 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930782002577 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930782002578 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 930782002579 active site 930782002580 catalytic residues [active] 930782002581 metal binding site [ion binding]; metal-binding site 930782002582 homodimer binding site [polypeptide binding]; other site 930782002583 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930782002584 carboxyltransferase (CT) interaction site; other site 930782002585 biotinylation site [posttranslational modification]; other site 930782002586 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 930782002587 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930782002588 putative binding site residues; other site 930782002589 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 930782002590 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 930782002591 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 930782002592 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 930782002593 Walker A/P-loop; other site 930782002594 ATP binding site [chemical binding]; other site 930782002595 Q-loop/lid; other site 930782002596 ABC transporter signature motif; other site 930782002597 Walker B; other site 930782002598 D-loop; other site 930782002599 H-loop/switch region; other site 930782002600 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782002601 SH3-like domain; Region: SH3_8; pfam13457 930782002602 SH3-like domain; Region: SH3_8; pfam13457 930782002603 SH3-like domain; Region: SH3_8; pfam13457 930782002604 SH3-like domain; Region: SH3_8; pfam13457 930782002605 SH3-like domain; Region: SH3_8; pfam13457 930782002606 SH3-like domain; Region: SH3_8; pfam13457 930782002607 SH3-like domain; Region: SH3_8; pfam13457 930782002608 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 930782002609 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 930782002610 Ligand binding site; other site 930782002611 Putative Catalytic site; other site 930782002612 DXD motif; other site 930782002613 conserved hypothetical integral membrane protein; Region: TIGR03766 930782002614 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 930782002615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930782002616 active site 930782002617 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930782002618 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 930782002619 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 930782002620 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 930782002621 active site 930782002622 tetramer interface; other site 930782002623 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 930782002624 substrate binding site; other site 930782002625 dimer interface; other site 930782002626 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 930782002627 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930782002628 putative NAD(P) binding site [chemical binding]; other site 930782002629 putative catalytic Zn binding site [ion binding]; other site 930782002630 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 930782002631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 930782002632 active site 930782002633 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930782002634 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 930782002635 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 930782002636 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 930782002637 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 930782002638 active site 930782002639 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 930782002640 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 930782002641 active site 930782002642 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 930782002643 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 930782002644 homodimer interface [polypeptide binding]; other site 930782002645 NAD binding pocket [chemical binding]; other site 930782002646 ATP binding pocket [chemical binding]; other site 930782002647 Mg binding site [ion binding]; other site 930782002648 active-site loop [active] 930782002649 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930782002650 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 930782002651 active site 930782002652 P-loop; other site 930782002653 phosphorylation site [posttranslational modification] 930782002654 GMP synthase; Reviewed; Region: guaA; PRK00074 930782002655 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 930782002656 AMP/PPi binding site [chemical binding]; other site 930782002657 candidate oxyanion hole; other site 930782002658 catalytic triad [active] 930782002659 potential glutamine specificity residues [chemical binding]; other site 930782002660 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 930782002661 ATP Binding subdomain [chemical binding]; other site 930782002662 Dimerization subdomain; other site 930782002663 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 930782002664 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782002665 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782002666 ATP binding site [chemical binding]; other site 930782002667 putative Mg++ binding site [ion binding]; other site 930782002668 T5orf172 domain; Region: T5orf172; pfam10544 930782002669 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 930782002670 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 930782002671 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930782002672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930782002673 MepB protein; Region: MepB; cl01985 930782002674 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930782002675 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782002676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782002677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782002678 Coenzyme A binding pocket [chemical binding]; other site 930782002679 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 930782002680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782002681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782002682 Walker A/P-loop; other site 930782002683 ATP binding site [chemical binding]; other site 930782002684 Q-loop/lid; other site 930782002685 ABC transporter signature motif; other site 930782002686 Walker B; other site 930782002687 D-loop; other site 930782002688 H-loop/switch region; other site 930782002689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782002690 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782002691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782002692 Walker A/P-loop; other site 930782002693 ATP binding site [chemical binding]; other site 930782002694 Q-loop/lid; other site 930782002695 ABC transporter signature motif; other site 930782002696 Walker B; other site 930782002697 D-loop; other site 930782002698 H-loop/switch region; other site 930782002699 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930782002700 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782002701 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782002702 DNA binding residues [nucleotide binding] 930782002703 putative dimer interface [polypeptide binding]; other site 930782002704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930782002705 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 930782002706 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782002707 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782002708 LRR adjacent; Region: LRR_adjacent; pfam08191 930782002709 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782002710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 930782002711 Clp protease; Region: CLP_protease; pfam00574 930782002712 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930782002713 oligomer interface [polypeptide binding]; other site 930782002714 active site residues [active] 930782002715 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930782002716 dimer interface [polypeptide binding]; other site 930782002717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782002718 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 930782002719 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 930782002720 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 930782002721 SLBB domain; Region: SLBB; pfam10531 930782002722 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 930782002723 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 930782002724 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002725 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 930782002726 putative hexamer interface [polypeptide binding]; other site 930782002727 putative hexagonal pore; other site 930782002728 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 930782002729 putative hexamer interface [polypeptide binding]; other site 930782002730 putative hexagonal pore; other site 930782002731 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 930782002732 putative hexamer interface [polypeptide binding]; other site 930782002733 putative hexagonal pore; other site 930782002734 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 930782002735 G1 box; other site 930782002736 GTP/Mg2+ binding site [chemical binding]; other site 930782002737 G2 box; other site 930782002738 Switch I region; other site 930782002739 G3 box; other site 930782002740 Switch II region; other site 930782002741 G4 box; other site 930782002742 G5 box; other site 930782002743 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 930782002744 homotrimer interface [polypeptide binding]; other site 930782002745 Walker A motif; other site 930782002746 GTP binding site [chemical binding]; other site 930782002747 Walker B motif; other site 930782002748 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 930782002749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782002750 catalytic core [active] 930782002751 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 930782002752 Sensory domain found in PocR; Region: PocR; pfam10114 930782002753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782002754 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782002755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782002756 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002757 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930782002758 Hexamer interface [polypeptide binding]; other site 930782002759 Hexagonal pore residue; other site 930782002760 propanediol utilization protein PduB; Provisional; Region: PRK15415 930782002761 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 930782002762 putative hexamer interface [polypeptide binding]; other site 930782002763 putative hexagonal pore; other site 930782002764 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 930782002765 putative hexamer interface [polypeptide binding]; other site 930782002766 putative hexagonal pore; other site 930782002767 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 930782002768 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 930782002769 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 930782002770 alpha-beta subunit interface [polypeptide binding]; other site 930782002771 alpha-gamma subunit interface [polypeptide binding]; other site 930782002772 active site 930782002773 substrate and K+ binding site; other site 930782002774 K+ binding site [ion binding]; other site 930782002775 cobalamin binding site [chemical binding]; other site 930782002776 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 930782002777 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 930782002778 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 930782002779 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 930782002780 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002781 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 930782002782 putative hexamer interface [polypeptide binding]; other site 930782002783 putative hexagonal pore; other site 930782002784 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002785 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930782002786 Hexamer interface [polypeptide binding]; other site 930782002787 Hexagonal pore residue; other site 930782002788 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 930782002789 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930782002790 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930782002791 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 930782002792 Cell division protein FtsA; Region: FtsA; cl17206 930782002793 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930782002794 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 930782002795 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 930782002796 Hexamer/Pentamer interface [polypeptide binding]; other site 930782002797 central pore; other site 930782002798 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 930782002799 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 930782002800 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 930782002801 putative catalytic cysteine [active] 930782002802 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930782002803 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 930782002804 putative active site [active] 930782002805 metal binding site [ion binding]; metal-binding site 930782002806 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 930782002807 amphipathic channel; other site 930782002808 Asn-Pro-Ala signature motifs; other site 930782002809 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930782002810 propionate/acetate kinase; Provisional; Region: PRK12379 930782002811 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 930782002812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782002813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782002814 homodimer interface [polypeptide binding]; other site 930782002815 catalytic residue [active] 930782002816 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 930782002817 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 930782002818 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 930782002819 putative active site [active] 930782002820 metal binding site [ion binding]; metal-binding site 930782002821 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 930782002822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782002823 active site 930782002824 phosphorylation site [posttranslational modification] 930782002825 intermolecular recognition site; other site 930782002826 dimerization interface [polypeptide binding]; other site 930782002827 ANTAR domain; Region: ANTAR; pfam03861 930782002828 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 930782002829 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 930782002830 Histidine kinase; Region: HisKA_2; pfam07568 930782002831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782002832 ATP binding site [chemical binding]; other site 930782002833 Mg2+ binding site [ion binding]; other site 930782002834 G-X-G motif; other site 930782002835 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 930782002836 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 930782002837 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 930782002838 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 930782002839 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 930782002840 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 930782002841 putative hexamer interface [polypeptide binding]; other site 930782002842 putative hexagonal pore; other site 930782002843 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 930782002844 putative hexamer interface [polypeptide binding]; other site 930782002845 putative hexagonal pore; other site 930782002846 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002847 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 930782002848 Hexamer interface [polypeptide binding]; other site 930782002849 Hexagonal pore residue; other site 930782002850 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 930782002851 putative catalytic cysteine [active] 930782002852 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 930782002853 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 930782002854 Hexamer interface [polypeptide binding]; other site 930782002855 Putative hexagonal pore residue; other site 930782002856 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 930782002857 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 930782002858 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930782002859 Propanediol utilisation protein PduL; Region: PduL; pfam06130 930782002860 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 930782002861 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 930782002862 Hexamer/Pentamer interface [polypeptide binding]; other site 930782002863 central pore; other site 930782002864 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 930782002865 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 930782002866 putative hexamer interface [polypeptide binding]; other site 930782002867 putative hexagonal pore; other site 930782002868 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 930782002869 putative hexamer interface [polypeptide binding]; other site 930782002870 putative hexagonal pore; other site 930782002871 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 930782002872 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 930782002873 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 930782002874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782002875 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782002876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782002877 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 930782002878 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930782002879 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 930782002880 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 930782002881 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 930782002882 catalytic triad [active] 930782002883 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 930782002884 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 930782002885 Precorrin-8X methylmutase; Region: CbiC; pfam02570 930782002886 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 930782002887 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 930782002888 active site 930782002889 putative homodimer interface [polypeptide binding]; other site 930782002890 SAM binding site [chemical binding]; other site 930782002891 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 930782002892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782002893 S-adenosylmethionine binding site [chemical binding]; other site 930782002894 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 930782002895 active site 930782002896 SAM binding site [chemical binding]; other site 930782002897 homodimer interface [polypeptide binding]; other site 930782002898 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 930782002899 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 930782002900 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 930782002901 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 930782002902 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 930782002903 active site 930782002904 SAM binding site [chemical binding]; other site 930782002905 homodimer interface [polypeptide binding]; other site 930782002906 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 930782002907 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 930782002908 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 930782002909 active site 930782002910 SAM binding site [chemical binding]; other site 930782002911 homodimer interface [polypeptide binding]; other site 930782002912 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 930782002913 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930782002914 active site 930782002915 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 930782002916 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 930782002917 active site 930782002918 C-terminal domain interface [polypeptide binding]; other site 930782002919 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 930782002920 active site 930782002921 N-terminal domain interface [polypeptide binding]; other site 930782002922 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 930782002923 active site 930782002924 SAM binding site [chemical binding]; other site 930782002925 homodimer interface [polypeptide binding]; other site 930782002926 cobalt transport protein CbiM; Validated; Region: PRK08319 930782002927 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 930782002928 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 930782002929 cobalt transport protein CbiQ; Provisional; Region: PRK15485 930782002930 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 930782002931 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930782002932 Walker A/P-loop; other site 930782002933 ATP binding site [chemical binding]; other site 930782002934 Q-loop/lid; other site 930782002935 ABC transporter signature motif; other site 930782002936 Walker B; other site 930782002937 D-loop; other site 930782002938 H-loop/switch region; other site 930782002939 cobyric acid synthase; Provisional; Region: PRK00784 930782002940 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930782002941 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930782002942 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 930782002943 catalytic triad [active] 930782002944 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 930782002945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 930782002946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 930782002947 AAA domain; Region: AAA_17; cl17253 930782002948 Predicted transcriptional regulators [Transcription]; Region: COG1695 930782002949 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930782002950 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 930782002951 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782002952 SH3-like domain; Region: SH3_8; pfam13457 930782002953 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782002954 SH3-like domain; Region: SH3_8; pfam13457 930782002955 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930782002956 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930782002957 oligomer interface [polypeptide binding]; other site 930782002958 active site 930782002959 metal binding site [ion binding]; metal-binding site 930782002960 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 930782002961 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 930782002962 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 930782002963 Predicted transcriptional regulators [Transcription]; Region: COG1733 930782002964 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 930782002965 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 930782002966 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 930782002967 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 930782002968 dimer interface [polypeptide binding]; other site 930782002969 motif 1; other site 930782002970 active site 930782002971 motif 2; other site 930782002972 motif 3; other site 930782002973 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 930782002974 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930782002975 putative tRNA-binding site [nucleotide binding]; other site 930782002976 B3/4 domain; Region: B3_4; pfam03483 930782002977 tRNA synthetase B5 domain; Region: B5; smart00874 930782002978 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 930782002979 dimer interface [polypeptide binding]; other site 930782002980 motif 1; other site 930782002981 motif 3; other site 930782002982 motif 2; other site 930782002983 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 930782002984 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782002985 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782002986 Walker A/P-loop; other site 930782002987 ATP binding site [chemical binding]; other site 930782002988 Q-loop/lid; other site 930782002989 ABC transporter signature motif; other site 930782002990 Walker B; other site 930782002991 D-loop; other site 930782002992 H-loop/switch region; other site 930782002993 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782002994 FtsX-like permease family; Region: FtsX; pfam02687 930782002995 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930782002996 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782002997 FtsX-like permease family; Region: FtsX; pfam02687 930782002998 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930782002999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782003000 putative DNA binding site [nucleotide binding]; other site 930782003001 putative Zn2+ binding site [ion binding]; other site 930782003002 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 930782003003 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 930782003004 ligand binding site [chemical binding]; other site 930782003005 active site 930782003006 UGI interface [polypeptide binding]; other site 930782003007 catalytic site [active] 930782003008 ribonuclease HIII; Provisional; Region: PRK00996 930782003009 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 930782003010 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 930782003011 RNA/DNA hybrid binding site [nucleotide binding]; other site 930782003012 active site 930782003013 Cell division protein ZapA; Region: ZapA; cl01146 930782003014 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 930782003015 Colicin V production protein; Region: Colicin_V; pfam02674 930782003016 hypothetical protein; Provisional; Region: PRK08609 930782003017 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 930782003018 active site 930782003019 primer binding site [nucleotide binding]; other site 930782003020 NTP binding site [chemical binding]; other site 930782003021 metal binding triad [ion binding]; metal-binding site 930782003022 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 930782003023 active site 930782003024 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 930782003025 MutS domain III; Region: MutS_III; pfam05192 930782003026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782003027 Walker A/P-loop; other site 930782003028 ATP binding site [chemical binding]; other site 930782003029 Q-loop/lid; other site 930782003030 ABC transporter signature motif; other site 930782003031 Walker B; other site 930782003032 D-loop; other site 930782003033 H-loop/switch region; other site 930782003034 Smr domain; Region: Smr; pfam01713 930782003035 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782003036 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930782003037 catalytic residues [active] 930782003038 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 930782003039 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 930782003040 GIY-YIG motif/motif A; other site 930782003041 active site 930782003042 catalytic site [active] 930782003043 putative DNA binding site [nucleotide binding]; other site 930782003044 metal binding site [ion binding]; metal-binding site 930782003045 UvrB/uvrC motif; Region: UVR; pfam02151 930782003046 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 930782003047 aspartate kinase; Reviewed; Region: PRK06635 930782003048 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 930782003049 putative nucleotide binding site [chemical binding]; other site 930782003050 putative catalytic residues [active] 930782003051 putative Mg ion binding site [ion binding]; other site 930782003052 putative aspartate binding site [chemical binding]; other site 930782003053 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 930782003054 putative allosteric regulatory site; other site 930782003055 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 930782003056 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 930782003057 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 930782003058 ribonuclease PH; Reviewed; Region: rph; PRK00173 930782003059 Ribonuclease PH; Region: RNase_PH_bact; cd11362 930782003060 hexamer interface [polypeptide binding]; other site 930782003061 active site 930782003062 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 930782003063 active site 930782003064 dimerization interface [polypeptide binding]; other site 930782003065 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 930782003066 active site 930782003067 metal binding site [ion binding]; metal-binding site 930782003068 homotetramer interface [polypeptide binding]; other site 930782003069 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 930782003070 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930782003071 Int/Topo IB signature motif; other site 930782003072 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930782003073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782003074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782003075 non-specific DNA binding site [nucleotide binding]; other site 930782003076 salt bridge; other site 930782003077 sequence-specific DNA binding site [nucleotide binding]; other site 930782003078 Protein of unknown function (DUF1250); Region: DUF1250; pfam06855 930782003079 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 930782003080 salt bridge; other site 930782003081 non-specific DNA binding site [nucleotide binding]; other site 930782003082 sequence-specific DNA binding site [nucleotide binding]; other site 930782003083 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 930782003084 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930782003085 cofactor binding site; other site 930782003086 DNA binding site [nucleotide binding] 930782003087 substrate interaction site [chemical binding]; other site 930782003088 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 930782003089 YopX protein; Region: YopX; cl09859 930782003090 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 930782003091 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 930782003092 AAA domain; Region: AAA_24; pfam13479 930782003093 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 930782003094 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782003095 ATP binding site [chemical binding]; other site 930782003096 putative Mg++ binding site [ion binding]; other site 930782003097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782003098 nucleotide binding region [chemical binding]; other site 930782003099 ATP-binding site [chemical binding]; other site 930782003100 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 930782003101 Protein of unknown function (DUF669); Region: DUF669; pfam05037 930782003102 Uncharacterized conserved protein [Function unknown]; Region: COG4983 930782003103 Phage associated DNA primase [General function prediction only]; Region: COG3378 930782003104 D5 N terminal like; Region: D5_N; pfam08706 930782003105 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 930782003106 VRR-NUC domain; Region: VRR_NUC; pfam08774 930782003107 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 930782003108 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 930782003109 Protein of unknown function (DUF722); Region: DUF722; pfam05263 930782003110 HNH endonuclease; Region: HNH; pfam01844 930782003111 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 930782003112 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 930782003113 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 930782003114 oligomer interface [polypeptide binding]; other site 930782003115 Clp protease; Region: CLP_protease; pfam00574 930782003116 active site residues [active] 930782003117 Phage capsid family; Region: Phage_capsid; pfam05065 930782003118 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 930782003119 Phage-related minor tail protein [Function unknown]; Region: COG5280 930782003120 membrane protein P6; Region: PHA01399 930782003121 Phage-related protein [Function unknown]; Region: COG4722 930782003122 Phage tail protein; Region: Sipho_tail; pfam05709 930782003123 Phage-related protein [Function unknown]; Region: PblB; COG4926 930782003124 phage minor structural protein, N-terminal region; Region: put_anti_recept; TIGR01665 930782003125 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 930782003126 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 930782003127 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 930782003128 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; cl09900 930782003129 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 930782003130 Phage holin; Region: Phage_holin_5; pfam06946 930782003131 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 930782003132 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930782003133 Leucine rich repeat; Region: LRR_8; pfam13855 930782003134 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782003135 LRR adjacent; Region: LRR_adjacent; pfam08191 930782003136 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003137 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003138 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003139 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003140 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003141 Uncharacterized conserved protein [Function unknown]; Region: COG5361 930782003142 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 930782003143 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 930782003144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 930782003145 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 930782003146 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 930782003147 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930782003148 dimer interface [polypeptide binding]; other site 930782003149 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782003150 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782003151 catalytic core [active] 930782003152 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 930782003153 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930782003154 ATP binding site [chemical binding]; other site 930782003155 Mg++ binding site [ion binding]; other site 930782003156 motif III; other site 930782003157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782003158 nucleotide binding region [chemical binding]; other site 930782003159 ATP-binding site [chemical binding]; other site 930782003160 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 930782003161 RNA binding site [nucleotide binding]; other site 930782003162 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930782003163 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 930782003164 putative active site [active] 930782003165 nucleotide binding site [chemical binding]; other site 930782003166 nudix motif; other site 930782003167 putative metal binding site [ion binding]; other site 930782003168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782003169 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782003170 putative substrate translocation pore; other site 930782003171 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782003172 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782003173 ligand binding site [chemical binding]; other site 930782003174 flexible hinge region; other site 930782003175 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782003176 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930782003177 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782003178 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782003179 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 930782003180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782003181 DNA-binding site [nucleotide binding]; DNA binding site 930782003182 UTRA domain; Region: UTRA; pfam07702 930782003183 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930782003184 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930782003185 Ca binding site [ion binding]; other site 930782003186 active site 930782003187 catalytic site [active] 930782003188 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930782003189 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 930782003190 active site turn [active] 930782003191 phosphorylation site [posttranslational modification] 930782003192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930782003193 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 930782003194 nudix motif; other site 930782003195 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 930782003196 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782003197 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 930782003198 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 930782003199 putative catalytic cysteine [active] 930782003200 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 930782003201 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 930782003202 nucleotide binding site [chemical binding]; other site 930782003203 homotetrameric interface [polypeptide binding]; other site 930782003204 putative phosphate binding site [ion binding]; other site 930782003205 putative allosteric binding site; other site 930782003206 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 930782003207 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 930782003208 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782003209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782003210 non-specific DNA binding site [nucleotide binding]; other site 930782003211 salt bridge; other site 930782003212 sequence-specific DNA binding site [nucleotide binding]; other site 930782003213 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782003214 non-specific DNA binding site [nucleotide binding]; other site 930782003215 salt bridge; other site 930782003216 sequence-specific DNA binding site [nucleotide binding]; other site 930782003217 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930782003218 active site 930782003219 trigger factor; Provisional; Region: tig; PRK01490 930782003220 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 930782003221 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 930782003222 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 930782003223 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 930782003224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782003225 Walker A motif; other site 930782003226 ATP binding site [chemical binding]; other site 930782003227 Walker B motif; other site 930782003228 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930782003229 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930782003230 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930782003231 Catalytic site [active] 930782003232 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930782003233 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 930782003234 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930782003235 Catalytic site [active] 930782003236 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 930782003237 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 930782003238 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930782003239 Catalytic site [active] 930782003240 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 930782003241 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 930782003242 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 930782003243 GTP/Mg2+ binding site [chemical binding]; other site 930782003244 G4 box; other site 930782003245 G5 box; other site 930782003246 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930782003247 G1 box; other site 930782003248 G1 box; other site 930782003249 GTP/Mg2+ binding site [chemical binding]; other site 930782003250 Switch I region; other site 930782003251 G2 box; other site 930782003252 G2 box; other site 930782003253 G3 box; other site 930782003254 G3 box; other site 930782003255 Switch II region; other site 930782003256 Switch II region; other site 930782003257 G5 box; other site 930782003258 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 930782003259 RNA/DNA hybrid binding site [nucleotide binding]; other site 930782003260 active site 930782003261 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 930782003262 DNA protecting protein DprA; Region: dprA; TIGR00732 930782003263 DNA topoisomerase I; Validated; Region: PRK05582 930782003264 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 930782003265 active site 930782003266 interdomain interaction site; other site 930782003267 putative metal-binding site [ion binding]; other site 930782003268 nucleotide binding site [chemical binding]; other site 930782003269 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930782003270 domain I; other site 930782003271 DNA binding groove [nucleotide binding] 930782003272 phosphate binding site [ion binding]; other site 930782003273 domain II; other site 930782003274 domain III; other site 930782003275 nucleotide binding site [chemical binding]; other site 930782003276 catalytic site [active] 930782003277 domain IV; other site 930782003278 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930782003279 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 930782003280 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 930782003281 Glucose inhibited division protein A; Region: GIDA; pfam01134 930782003282 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 930782003283 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 930782003284 active site 930782003285 DNA binding site [nucleotide binding] 930782003286 Int/Topo IB signature motif; other site 930782003287 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 930782003288 active site 930782003289 HslU subunit interaction site [polypeptide binding]; other site 930782003290 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 930782003291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782003292 Walker A motif; other site 930782003293 ATP binding site [chemical binding]; other site 930782003294 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 930782003295 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 930782003296 transcriptional repressor CodY; Validated; Region: PRK04158 930782003297 CodY GAF-like domain; Region: CodY; pfam06018 930782003298 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 930782003299 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 930782003300 active site 930782003301 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 930782003302 active site 930782003303 catalytic residues [active] 930782003304 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 930782003305 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 930782003306 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 930782003307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782003308 Mg2+ binding site [ion binding]; other site 930782003309 G-X-G motif; other site 930782003310 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930782003311 anchoring element; other site 930782003312 dimer interface [polypeptide binding]; other site 930782003313 ATP binding site [chemical binding]; other site 930782003314 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930782003315 active site 930782003316 putative metal-binding site [ion binding]; other site 930782003317 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930782003318 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 930782003319 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930782003320 CAP-like domain; other site 930782003321 active site 930782003322 primary dimer interface [polypeptide binding]; other site 930782003323 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782003324 S-ribosylhomocysteinase; Provisional; Region: PRK02260 930782003325 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 930782003326 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782003327 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 930782003328 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 930782003329 catalytic triad [active] 930782003330 catalytic triad [active] 930782003331 oxyanion hole [active] 930782003332 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 930782003333 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 930782003334 active site 930782003335 catalytic site [active] 930782003336 metal binding site [ion binding]; metal-binding site 930782003337 dimer interface [polypeptide binding]; other site 930782003338 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 930782003339 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 930782003340 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 930782003341 bacterial Hfq-like; Region: Hfq; cd01716 930782003342 hexamer interface [polypeptide binding]; other site 930782003343 Sm1 motif; other site 930782003344 RNA binding site [nucleotide binding]; other site 930782003345 Sm2 motif; other site 930782003346 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 930782003347 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 930782003348 HflX GTPase family; Region: HflX; cd01878 930782003349 G1 box; other site 930782003350 GTP/Mg2+ binding site [chemical binding]; other site 930782003351 Switch I region; other site 930782003352 G2 box; other site 930782003353 G3 box; other site 930782003354 Switch II region; other site 930782003355 G4 box; other site 930782003356 G5 box; other site 930782003357 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 930782003358 Aluminium resistance protein; Region: Alum_res; pfam06838 930782003359 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 930782003360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930782003361 DNA binding residues [nucleotide binding] 930782003362 putative dimer interface [polypeptide binding]; other site 930782003363 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 930782003364 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 930782003365 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 930782003366 arsenical pump membrane protein; Provisional; Region: PRK15445 930782003367 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 930782003368 transmembrane helices; other site 930782003369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930782003370 LexA repressor; Validated; Region: PRK00215 930782003371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782003372 putative DNA binding site [nucleotide binding]; other site 930782003373 putative Zn2+ binding site [ion binding]; other site 930782003374 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 930782003375 Catalytic site [active] 930782003376 cell division suppressor protein YneA; Provisional; Region: PRK14125 930782003377 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 930782003378 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 930782003379 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930782003380 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930782003381 TPP-binding site [chemical binding]; other site 930782003382 dimer interface [polypeptide binding]; other site 930782003383 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930782003384 PYR/PP interface [polypeptide binding]; other site 930782003385 dimer interface [polypeptide binding]; other site 930782003386 TPP binding site [chemical binding]; other site 930782003387 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782003388 hypothetical protein; Provisional; Region: PRK01844 930782003389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930782003390 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930782003391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782003392 S-adenosylmethionine binding site [chemical binding]; other site 930782003393 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 930782003394 ParB-like nuclease domain; Region: ParBc; pfam02195 930782003395 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 930782003396 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 930782003397 Active Sites [active] 930782003398 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 930782003399 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782003400 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 930782003401 putative nucleotide binding site [chemical binding]; other site 930782003402 uridine monophosphate binding site [chemical binding]; other site 930782003403 homohexameric interface [polypeptide binding]; other site 930782003404 ribosome recycling factor; Reviewed; Region: frr; PRK00083 930782003405 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 930782003406 hinge region; other site 930782003407 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 930782003408 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 930782003409 catalytic residue [active] 930782003410 putative FPP diphosphate binding site; other site 930782003411 putative FPP binding hydrophobic cleft; other site 930782003412 dimer interface [polypeptide binding]; other site 930782003413 putative IPP diphosphate binding site; other site 930782003414 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 930782003415 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 930782003416 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 930782003417 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 930782003418 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 930782003419 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 930782003420 RIP metalloprotease RseP; Region: TIGR00054 930782003421 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930782003422 active site 930782003423 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 930782003424 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 930782003425 protein binding site [polypeptide binding]; other site 930782003426 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 930782003427 putative substrate binding region [chemical binding]; other site 930782003428 prolyl-tRNA synthetase; Provisional; Region: PRK09194 930782003429 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 930782003430 dimer interface [polypeptide binding]; other site 930782003431 motif 1; other site 930782003432 active site 930782003433 motif 2; other site 930782003434 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 930782003435 putative deacylase active site [active] 930782003436 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 930782003437 active site 930782003438 motif 3; other site 930782003439 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 930782003440 anticodon binding site; other site 930782003441 DNA polymerase III PolC; Validated; Region: polC; PRK00448 930782003442 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 930782003443 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 930782003444 generic binding surface II; other site 930782003445 generic binding surface I; other site 930782003446 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 930782003447 active site 930782003448 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930782003449 active site 930782003450 catalytic site [active] 930782003451 substrate binding site [chemical binding]; other site 930782003452 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 930782003453 ribosome maturation protein RimP; Reviewed; Region: PRK00092 930782003454 Sm and related proteins; Region: Sm_like; cl00259 930782003455 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 930782003456 putative oligomer interface [polypeptide binding]; other site 930782003457 putative RNA binding site [nucleotide binding]; other site 930782003458 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 930782003459 NusA N-terminal domain; Region: NusA_N; pfam08529 930782003460 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 930782003461 RNA binding site [nucleotide binding]; other site 930782003462 homodimer interface [polypeptide binding]; other site 930782003463 NusA-like KH domain; Region: KH_5; pfam13184 930782003464 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 930782003465 G-X-X-G motif; other site 930782003466 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 930782003467 putative RNA binding cleft [nucleotide binding]; other site 930782003468 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 930782003469 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930782003470 translation initiation factor IF-2; Region: IF-2; TIGR00487 930782003471 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 930782003472 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 930782003473 G1 box; other site 930782003474 putative GEF interaction site [polypeptide binding]; other site 930782003475 GTP/Mg2+ binding site [chemical binding]; other site 930782003476 Switch I region; other site 930782003477 G2 box; other site 930782003478 G3 box; other site 930782003479 Switch II region; other site 930782003480 G4 box; other site 930782003481 G5 box; other site 930782003482 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 930782003483 Translation-initiation factor 2; Region: IF-2; pfam11987 930782003484 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 930782003485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 930782003486 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 930782003487 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 930782003488 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 930782003489 RNA binding site [nucleotide binding]; other site 930782003490 active site 930782003491 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 930782003492 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 930782003493 active site 930782003494 Riboflavin kinase; Region: Flavokinase; smart00904 930782003495 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 930782003496 16S/18S rRNA binding site [nucleotide binding]; other site 930782003497 S13e-L30e interaction site [polypeptide binding]; other site 930782003498 25S rRNA binding site [nucleotide binding]; other site 930782003499 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 930782003500 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 930782003501 RNase E interface [polypeptide binding]; other site 930782003502 trimer interface [polypeptide binding]; other site 930782003503 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 930782003504 RNase E interface [polypeptide binding]; other site 930782003505 trimer interface [polypeptide binding]; other site 930782003506 active site 930782003507 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 930782003508 putative nucleic acid binding region [nucleotide binding]; other site 930782003509 G-X-X-G motif; other site 930782003510 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 930782003511 RNA binding site [nucleotide binding]; other site 930782003512 domain interface; other site 930782003513 GTPase RsgA; Reviewed; Region: PRK01889 930782003514 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930782003515 RNA binding site [nucleotide binding]; other site 930782003516 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930782003517 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930782003518 GTP/Mg2+ binding site [chemical binding]; other site 930782003519 G4 box; other site 930782003520 G5 box; other site 930782003521 G1 box; other site 930782003522 Switch I region; other site 930782003523 G2 box; other site 930782003524 G3 box; other site 930782003525 Switch II region; other site 930782003526 YceG-like family; Region: YceG; pfam02618 930782003527 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 930782003528 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 930782003529 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 930782003530 Rhomboid family; Region: Rhomboid; pfam01694 930782003531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782003532 TPR motif; other site 930782003533 TPR repeat; Region: TPR_11; pfam13414 930782003534 binding surface 930782003535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 930782003536 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 930782003537 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782003538 nucleotide binding site [chemical binding]; other site 930782003539 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 930782003540 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 930782003541 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 930782003542 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 930782003543 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930782003544 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 930782003545 Type II/IV secretion system protein; Region: T2SE; pfam00437 930782003546 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930782003547 Walker A motif; other site 930782003548 ATP binding site [chemical binding]; other site 930782003549 Walker B motif; other site 930782003550 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 930782003551 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 930782003552 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 930782003553 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 930782003554 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930782003555 tetramer interface [polypeptide binding]; other site 930782003556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782003557 catalytic residue [active] 930782003558 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 930782003559 tetramer interface [polypeptide binding]; other site 930782003560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782003561 catalytic residue [active] 930782003562 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 930782003563 active site residue [active] 930782003564 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 930782003565 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930782003566 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930782003567 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930782003568 active site 930782003569 elongation factor P; Validated; Region: PRK00529 930782003570 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 930782003571 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 930782003572 RNA binding site [nucleotide binding]; other site 930782003573 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 930782003574 RNA binding site [nucleotide binding]; other site 930782003575 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 930782003576 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 930782003577 carboxyltransferase (CT) interaction site; other site 930782003578 biotinylation site [posttranslational modification]; other site 930782003579 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 930782003580 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930782003581 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930782003582 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 930782003583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 930782003584 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 930782003585 putative RNA binding site [nucleotide binding]; other site 930782003586 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 930782003587 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 930782003588 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 930782003589 homodimer interface [polypeptide binding]; other site 930782003590 NADP binding site [chemical binding]; other site 930782003591 substrate binding site [chemical binding]; other site 930782003592 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 930782003593 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 930782003594 generic binding surface II; other site 930782003595 generic binding surface I; other site 930782003596 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 930782003597 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930782003598 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930782003599 substrate binding pocket [chemical binding]; other site 930782003600 chain length determination region; other site 930782003601 substrate-Mg2+ binding site; other site 930782003602 catalytic residues [active] 930782003603 aspartate-rich region 1; other site 930782003604 active site lid residues [active] 930782003605 aspartate-rich region 2; other site 930782003606 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930782003607 DNA-binding site [nucleotide binding]; DNA binding site 930782003608 RNA-binding motif; other site 930782003609 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 930782003610 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 930782003611 TPP-binding site; other site 930782003612 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930782003613 PYR/PP interface [polypeptide binding]; other site 930782003614 dimer interface [polypeptide binding]; other site 930782003615 TPP binding site [chemical binding]; other site 930782003616 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782003617 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 930782003618 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782003619 RNA binding surface [nucleotide binding]; other site 930782003620 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 930782003621 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 930782003622 arginine repressor; Provisional; Region: PRK04280 930782003623 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 930782003624 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 930782003625 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930782003626 Walker A/P-loop; other site 930782003627 ATP binding site [chemical binding]; other site 930782003628 Q-loop/lid; other site 930782003629 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 930782003630 ABC transporter signature motif; other site 930782003631 Walker B; other site 930782003632 D-loop; other site 930782003633 H-loop/switch region; other site 930782003634 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 930782003635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782003636 nucleotide binding site [chemical binding]; other site 930782003637 Acetokinase family; Region: Acetate_kinase; cl17229 930782003638 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 930782003639 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782003640 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930782003641 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 930782003642 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 930782003643 tetramer interface [polypeptide binding]; other site 930782003644 TPP-binding site [chemical binding]; other site 930782003645 heterodimer interface [polypeptide binding]; other site 930782003646 phosphorylation loop region [posttranslational modification] 930782003647 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 930782003648 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 930782003649 alpha subunit interface [polypeptide binding]; other site 930782003650 TPP binding site [chemical binding]; other site 930782003651 heterodimer interface [polypeptide binding]; other site 930782003652 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 930782003653 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 930782003654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 930782003655 E3 interaction surface; other site 930782003656 lipoyl attachment site [posttranslational modification]; other site 930782003657 e3 binding domain; Region: E3_binding; pfam02817 930782003658 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 930782003659 peptidase T-like protein; Region: PepT-like; TIGR01883 930782003660 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 930782003661 metal binding site [ion binding]; metal-binding site 930782003662 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 930782003663 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 930782003664 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 930782003665 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782003666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782003667 active site 930782003668 phosphorylation site [posttranslational modification] 930782003669 intermolecular recognition site; other site 930782003670 dimerization interface [polypeptide binding]; other site 930782003671 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782003672 DNA binding site [nucleotide binding] 930782003673 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930782003674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782003675 dimerization interface [polypeptide binding]; other site 930782003676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782003677 dimer interface [polypeptide binding]; other site 930782003678 phosphorylation site [posttranslational modification] 930782003679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782003680 ATP binding site [chemical binding]; other site 930782003681 Mg2+ binding site [ion binding]; other site 930782003682 G-X-G motif; other site 930782003683 OxaA-like protein precursor; Validated; Region: PRK01622 930782003684 acylphosphatase; Provisional; Region: PRK14443 930782003685 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 930782003686 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 930782003687 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 930782003688 homotetramer interface [polypeptide binding]; other site 930782003689 FMN binding site [chemical binding]; other site 930782003690 homodimer contacts [polypeptide binding]; other site 930782003691 putative active site [active] 930782003692 putative substrate binding site [chemical binding]; other site 930782003693 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 930782003694 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 930782003695 active site residue [active] 930782003696 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 930782003697 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930782003698 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782003699 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782003700 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 930782003701 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930782003702 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930782003703 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930782003704 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 930782003705 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 930782003706 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 930782003707 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 930782003708 ligand binding site [chemical binding]; other site 930782003709 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 930782003710 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 930782003711 Walker A/P-loop; other site 930782003712 ATP binding site [chemical binding]; other site 930782003713 Q-loop/lid; other site 930782003714 ABC transporter signature motif; other site 930782003715 Walker B; other site 930782003716 D-loop; other site 930782003717 H-loop/switch region; other site 930782003718 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 930782003719 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930782003720 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930782003721 TM-ABC transporter signature motif; other site 930782003722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 930782003723 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 930782003724 TM-ABC transporter signature motif; other site 930782003725 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930782003726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930782003727 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 930782003728 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 930782003729 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 930782003730 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930782003731 classical (c) SDRs; Region: SDR_c; cd05233 930782003732 NAD(P) binding site [chemical binding]; other site 930782003733 active site 930782003734 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 930782003735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782003736 non-specific DNA binding site [nucleotide binding]; other site 930782003737 salt bridge; other site 930782003738 sequence-specific DNA binding site [nucleotide binding]; other site 930782003739 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 930782003740 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 930782003741 competence damage-inducible protein A; Provisional; Region: PRK00549 930782003742 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 930782003743 putative MPT binding site; other site 930782003744 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 930782003745 recombinase A; Provisional; Region: recA; PRK09354 930782003746 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 930782003747 hexamer interface [polypeptide binding]; other site 930782003748 Walker A motif; other site 930782003749 ATP binding site [chemical binding]; other site 930782003750 Walker B motif; other site 930782003751 phosphodiesterase; Provisional; Region: PRK12704 930782003752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782003753 Zn2+ binding site [ion binding]; other site 930782003754 Mg2+ binding site [ion binding]; other site 930782003755 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 930782003756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782003757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930782003758 Coenzyme A binding pocket [chemical binding]; other site 930782003759 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 930782003760 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930782003761 putative active site [active] 930782003762 metal binding site [ion binding]; metal-binding site 930782003763 homodimer binding site [polypeptide binding]; other site 930782003764 Predicted membrane protein [Function unknown]; Region: COG4550 930782003765 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 930782003766 MutS domain I; Region: MutS_I; pfam01624 930782003767 MutS domain II; Region: MutS_II; pfam05188 930782003768 MutS domain III; Region: MutS_III; pfam05192 930782003769 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 930782003770 Walker A/P-loop; other site 930782003771 ATP binding site [chemical binding]; other site 930782003772 Q-loop/lid; other site 930782003773 ABC transporter signature motif; other site 930782003774 Walker B; other site 930782003775 D-loop; other site 930782003776 H-loop/switch region; other site 930782003777 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 930782003778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782003779 ATP binding site [chemical binding]; other site 930782003780 Mg2+ binding site [ion binding]; other site 930782003781 G-X-G motif; other site 930782003782 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 930782003783 ATP binding site [chemical binding]; other site 930782003784 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 930782003785 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 930782003786 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 930782003787 Pyruvate formate lyase 1; Region: PFL1; cd01678 930782003788 coenzyme A binding site [chemical binding]; other site 930782003789 active site 930782003790 catalytic residues [active] 930782003791 glycine loop; other site 930782003792 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 930782003793 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930782003794 FeS/SAM binding site; other site 930782003795 Predicted transcriptional regulators [Transcription]; Region: COG1695 930782003796 Transcriptional regulator PadR-like family; Region: PadR; cl17335 930782003797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782003798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782003799 putative substrate translocation pore; other site 930782003800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782003801 non-specific DNA binding site [nucleotide binding]; other site 930782003802 salt bridge; other site 930782003803 sequence-specific DNA binding site [nucleotide binding]; other site 930782003804 topology modulation protein; Reviewed; Region: PRK08118 930782003805 AAA domain; Region: AAA_17; pfam13207 930782003806 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003807 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003808 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782003809 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782003810 putative acyltransferase; Provisional; Region: PRK05790 930782003811 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 930782003812 dimer interface [polypeptide binding]; other site 930782003813 active site 930782003814 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 930782003815 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 930782003816 dimer interface [polypeptide binding]; other site 930782003817 active site 930782003818 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930782003819 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 930782003820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782003821 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 930782003822 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 930782003823 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 930782003824 Domain of unknown function DUF20; Region: UPF0118; pfam01594 930782003825 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 930782003826 FAD binding domain; Region: FAD_binding_4; pfam01565 930782003827 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 930782003828 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 930782003829 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930782003830 Walker A/P-loop; other site 930782003831 ATP binding site [chemical binding]; other site 930782003832 Q-loop/lid; other site 930782003833 ABC transporter signature motif; other site 930782003834 Walker B; other site 930782003835 D-loop; other site 930782003836 H-loop/switch region; other site 930782003837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782003838 dimer interface [polypeptide binding]; other site 930782003839 conserved gate region; other site 930782003840 ABC-ATPase subunit interface; other site 930782003841 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 930782003842 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 930782003843 manganese transport protein MntH; Reviewed; Region: PRK00701 930782003844 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 930782003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782003846 dimer interface [polypeptide binding]; other site 930782003847 conserved gate region; other site 930782003848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 930782003849 ABC-ATPase subunit interface; other site 930782003850 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 930782003851 LysR substrate binding domain; Region: LysR_substrate; pfam03466 930782003852 dimerization interface [polypeptide binding]; other site 930782003853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782003854 dimer interface [polypeptide binding]; other site 930782003855 conserved gate region; other site 930782003856 putative PBP binding loops; other site 930782003857 ABC-ATPase subunit interface; other site 930782003858 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 930782003859 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 930782003860 Walker A/P-loop; other site 930782003861 ATP binding site [chemical binding]; other site 930782003862 Q-loop/lid; other site 930782003863 ABC transporter signature motif; other site 930782003864 Walker B; other site 930782003865 D-loop; other site 930782003866 H-loop/switch region; other site 930782003867 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 930782003868 Predicted membrane protein [Function unknown]; Region: COG3859 930782003869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 930782003870 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 930782003871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782003872 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782003873 ABC transporter; Region: ABC_tran_2; pfam12848 930782003874 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782003875 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 930782003876 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782003877 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782003878 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930782003879 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 930782003880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782003881 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 930782003882 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 930782003883 dihydrodipicolinate synthase; Region: dapA; TIGR00674 930782003884 dimer interface [polypeptide binding]; other site 930782003885 active site 930782003886 catalytic residue [active] 930782003887 aspartate kinase I; Reviewed; Region: PRK08210 930782003888 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 930782003889 nucleotide binding site [chemical binding]; other site 930782003890 substrate binding site [chemical binding]; other site 930782003891 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 930782003892 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 930782003893 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 930782003894 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930782003895 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930782003896 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930782003897 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930782003898 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 930782003899 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 930782003900 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 930782003901 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 930782003902 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 930782003903 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930782003904 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 930782003905 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 930782003906 Predicted membrane protein [Function unknown]; Region: COG4392 930782003907 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 930782003908 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930782003909 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930782003910 metal binding site 2 [ion binding]; metal-binding site 930782003911 putative DNA binding helix; other site 930782003912 metal binding site 1 [ion binding]; metal-binding site 930782003913 dimer interface [polypeptide binding]; other site 930782003914 structural Zn2+ binding site [ion binding]; other site 930782003915 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930782003916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782003917 ABC-ATPase subunit interface; other site 930782003918 dimer interface [polypeptide binding]; other site 930782003919 putative PBP binding regions; other site 930782003920 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 930782003921 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930782003922 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 930782003923 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 930782003924 DHHA2 domain; Region: DHHA2; pfam02833 930782003925 endonuclease IV; Provisional; Region: PRK01060 930782003926 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 930782003927 AP (apurinic/apyrimidinic) site pocket; other site 930782003928 DNA interaction; other site 930782003929 Metal-binding active site; metal-binding site 930782003930 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 930782003931 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782003932 ATP binding site [chemical binding]; other site 930782003933 Mg++ binding site [ion binding]; other site 930782003934 motif III; other site 930782003935 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782003936 nucleotide binding region [chemical binding]; other site 930782003937 ATP-binding site [chemical binding]; other site 930782003938 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 930782003939 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 930782003940 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930782003941 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930782003942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 930782003943 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 930782003944 Uncharacterized conserved protein [Function unknown]; Region: COG0327 930782003945 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 930782003946 Family of unknown function (DUF633); Region: DUF633; pfam04816 930782003947 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 930782003948 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 930782003949 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 930782003950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 930782003951 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 930782003952 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930782003953 DNA binding residues [nucleotide binding] 930782003954 DNA primase; Validated; Region: dnaG; PRK05667 930782003955 CHC2 zinc finger; Region: zf-CHC2; pfam01807 930782003956 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 930782003957 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 930782003958 active site 930782003959 metal binding site [ion binding]; metal-binding site 930782003960 interdomain interaction site; other site 930782003961 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 930782003962 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 930782003963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 930782003964 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 930782003965 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 930782003966 DALR anticodon binding domain; Region: DALR_1; pfam05746 930782003967 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 930782003968 dimer interface [polypeptide binding]; other site 930782003969 motif 1; other site 930782003970 active site 930782003971 motif 2; other site 930782003972 motif 3; other site 930782003973 DNA repair protein RecO; Region: reco; TIGR00613 930782003974 Recombination protein O N terminal; Region: RecO_N; pfam11967 930782003975 Recombination protein O C terminal; Region: RecO_C; pfam02565 930782003976 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 930782003977 GTPase Era; Reviewed; Region: era; PRK00089 930782003978 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 930782003979 G1 box; other site 930782003980 GTP/Mg2+ binding site [chemical binding]; other site 930782003981 Switch I region; other site 930782003982 G2 box; other site 930782003983 Switch II region; other site 930782003984 G3 box; other site 930782003985 G4 box; other site 930782003986 G5 box; other site 930782003987 KH domain; Region: KH_2; pfam07650 930782003988 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 930782003989 active site 930782003990 catalytic motif [active] 930782003991 Zn binding site [ion binding]; other site 930782003992 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 930782003993 metal-binding heat shock protein; Provisional; Region: PRK00016 930782003994 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 930782003995 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 930782003996 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782003997 Zn2+ binding site [ion binding]; other site 930782003998 Mg2+ binding site [ion binding]; other site 930782003999 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 930782004000 PhoH-like protein; Region: PhoH; pfam02562 930782004001 Yqey-like protein; Region: YqeY; pfam09424 930782004002 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 930782004003 RNA methyltransferase, RsmE family; Region: TIGR00046 930782004004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 930782004005 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 930782004006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004007 S-adenosylmethionine binding site [chemical binding]; other site 930782004008 chaperone protein DnaJ; Provisional; Region: PRK14280 930782004009 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 930782004010 HSP70 interaction site [polypeptide binding]; other site 930782004011 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 930782004012 substrate binding site [polypeptide binding]; other site 930782004013 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 930782004014 Zn binding sites [ion binding]; other site 930782004015 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 930782004016 dimer interface [polypeptide binding]; other site 930782004017 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 930782004018 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 930782004019 nucleotide binding site [chemical binding]; other site 930782004020 NEF interaction site [polypeptide binding]; other site 930782004021 SBD interface [polypeptide binding]; other site 930782004022 heat shock protein GrpE; Provisional; Region: PRK14140 930782004023 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 930782004024 dimer interface [polypeptide binding]; other site 930782004025 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 930782004026 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 930782004027 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 930782004028 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 930782004029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930782004030 FeS/SAM binding site; other site 930782004031 HemN C-terminal domain; Region: HemN_C; pfam06969 930782004032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930782004033 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 930782004034 NADP binding site [chemical binding]; other site 930782004035 putative substrate binding site [chemical binding]; other site 930782004036 active site 930782004037 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782004038 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782004039 DNA binding residues [nucleotide binding] 930782004040 putative dimer interface [polypeptide binding]; other site 930782004041 GTP-binding protein LepA; Provisional; Region: PRK05433 930782004042 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 930782004043 G1 box; other site 930782004044 putative GEF interaction site [polypeptide binding]; other site 930782004045 GTP/Mg2+ binding site [chemical binding]; other site 930782004046 Switch I region; other site 930782004047 G2 box; other site 930782004048 G3 box; other site 930782004049 Switch II region; other site 930782004050 G4 box; other site 930782004051 G5 box; other site 930782004052 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 930782004053 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 930782004054 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 930782004055 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 930782004056 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 930782004057 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 930782004058 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 930782004059 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 930782004060 Competence protein; Region: Competence; pfam03772 930782004061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782004062 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 930782004063 catalytic motif [active] 930782004064 Zn binding site [ion binding]; other site 930782004065 SLBB domain; Region: SLBB; pfam10531 930782004066 comEA protein; Region: comE; TIGR01259 930782004067 Helix-hairpin-helix motif; Region: HHH; pfam00633 930782004068 Methyltransferase domain; Region: Methyltransf_23; pfam13489 930782004069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004070 S-adenosylmethionine binding site [chemical binding]; other site 930782004071 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 930782004072 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782004073 Zn2+ binding site [ion binding]; other site 930782004074 Mg2+ binding site [ion binding]; other site 930782004075 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 930782004076 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 930782004077 active site 930782004078 (T/H)XGH motif; other site 930782004079 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 930782004080 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 930782004081 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930782004082 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930782004083 shikimate binding site; other site 930782004084 NAD(P) binding site [chemical binding]; other site 930782004085 GTPase YqeH; Provisional; Region: PRK13796 930782004086 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 930782004087 GTP/Mg2+ binding site [chemical binding]; other site 930782004088 G4 box; other site 930782004089 G5 box; other site 930782004090 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 930782004091 G1 box; other site 930782004092 G1 box; other site 930782004093 GTP/Mg2+ binding site [chemical binding]; other site 930782004094 G2 box; other site 930782004095 Switch I region; other site 930782004096 G2 box; other site 930782004097 Switch I region; other site 930782004098 G3 box; other site 930782004099 G3 box; other site 930782004100 Switch II region; other site 930782004101 Switch II region; other site 930782004102 G4 box; other site 930782004103 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 930782004104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782004105 motif II; other site 930782004106 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 930782004107 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 930782004108 active site 930782004109 Zn binding site [ion binding]; other site 930782004110 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 930782004111 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 930782004112 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 930782004113 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 930782004114 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 930782004115 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 930782004116 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 930782004117 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 930782004118 Sugar specificity; other site 930782004119 Pyrimidine base specificity; other site 930782004120 ATP-binding site [chemical binding]; other site 930782004121 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 930782004122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004123 S-adenosylmethionine binding site [chemical binding]; other site 930782004124 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 930782004125 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 930782004126 dimerization interface [polypeptide binding]; other site 930782004127 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930782004128 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930782004129 hypothetical protein; Provisional; Region: PRK13678 930782004130 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 930782004131 hypothetical protein; Provisional; Region: PRK05473 930782004132 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 930782004133 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 930782004134 motif 1; other site 930782004135 active site 930782004136 motif 2; other site 930782004137 motif 3; other site 930782004138 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930782004139 DHHA1 domain; Region: DHHA1; pfam02272 930782004140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782004141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782004142 Walker A/P-loop; other site 930782004143 ATP binding site [chemical binding]; other site 930782004144 Q-loop/lid; other site 930782004145 ABC transporter signature motif; other site 930782004146 Walker B; other site 930782004147 D-loop; other site 930782004148 H-loop/switch region; other site 930782004149 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782004150 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782004151 FtsX-like permease family; Region: FtsX; pfam02687 930782004152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782004153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782004154 active site 930782004155 phosphorylation site [posttranslational modification] 930782004156 intermolecular recognition site; other site 930782004157 dimerization interface [polypeptide binding]; other site 930782004158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782004159 DNA binding site [nucleotide binding] 930782004160 sensor kinase CusS; Provisional; Region: PRK09835 930782004161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782004162 dimerization interface [polypeptide binding]; other site 930782004163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782004164 dimer interface [polypeptide binding]; other site 930782004165 phosphorylation site [posttranslational modification] 930782004166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782004167 ATP binding site [chemical binding]; other site 930782004168 Mg2+ binding site [ion binding]; other site 930782004169 G-X-G motif; other site 930782004170 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 930782004171 AAA domain; Region: AAA_30; pfam13604 930782004172 Family description; Region: UvrD_C_2; pfam13538 930782004173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782004174 binding surface 930782004175 TPR motif; other site 930782004176 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 930782004177 TPR repeat; Region: TPR_11; pfam13414 930782004178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782004179 binding surface 930782004180 TPR motif; other site 930782004181 TPR repeat; Region: TPR_11; pfam13414 930782004182 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 930782004183 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 930782004184 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 930782004185 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930782004186 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930782004187 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782004188 catalytic residue [active] 930782004189 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 930782004190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782004191 Walker A motif; other site 930782004192 ATP binding site [chemical binding]; other site 930782004193 Walker B motif; other site 930782004194 arginine finger; other site 930782004195 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 930782004196 Predicted transcriptional regulator [Transcription]; Region: COG1959 930782004197 Transcriptional regulator; Region: Rrf2; pfam02082 930782004198 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 930782004199 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 930782004200 Nitrogen regulatory protein P-II; Region: P-II; smart00938 930782004201 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 930782004202 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 930782004203 dimer interface [polypeptide binding]; other site 930782004204 anticodon binding site; other site 930782004205 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930782004206 homodimer interface [polypeptide binding]; other site 930782004207 motif 1; other site 930782004208 active site 930782004209 motif 2; other site 930782004210 GAD domain; Region: GAD; pfam02938 930782004211 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 930782004212 motif 3; other site 930782004213 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 930782004214 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 930782004215 dimer interface [polypeptide binding]; other site 930782004216 motif 1; other site 930782004217 active site 930782004218 motif 2; other site 930782004219 motif 3; other site 930782004220 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 930782004221 anticodon binding site; other site 930782004222 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 930782004223 Bacterial SH3 domain; Region: SH3_3; pfam08239 930782004224 Bacterial SH3 domain; Region: SH3_3; pfam08239 930782004225 Bacterial SH3 domain homologues; Region: SH3b; smart00287 930782004226 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930782004227 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930782004228 active site 930782004229 metal binding site [ion binding]; metal-binding site 930782004230 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 930782004231 putative active site [active] 930782004232 dimerization interface [polypeptide binding]; other site 930782004233 putative tRNAtyr binding site [nucleotide binding]; other site 930782004234 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 930782004235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782004236 Zn2+ binding site [ion binding]; other site 930782004237 Mg2+ binding site [ion binding]; other site 930782004238 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 930782004239 synthetase active site [active] 930782004240 NTP binding site [chemical binding]; other site 930782004241 metal binding site [ion binding]; metal-binding site 930782004242 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 930782004243 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 930782004244 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782004245 active site 930782004246 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 930782004247 DHH family; Region: DHH; pfam01368 930782004248 DHHA1 domain; Region: DHHA1; pfam02272 930782004249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 930782004250 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 930782004251 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 930782004252 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 930782004253 Protein export membrane protein; Region: SecD_SecF; cl14618 930782004254 Protein export membrane protein; Region: SecD_SecF; pfam02355 930782004255 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 930782004256 Preprotein translocase subunit; Region: YajC; pfam02699 930782004257 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 930782004258 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 930782004259 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 930782004260 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 930782004261 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 930782004262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782004263 Walker A motif; other site 930782004264 ATP binding site [chemical binding]; other site 930782004265 Walker B motif; other site 930782004266 arginine finger; other site 930782004267 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 930782004268 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 930782004269 RuvA N terminal domain; Region: RuvA_N; pfam01330 930782004270 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 930782004271 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930782004272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782004273 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 930782004274 NAD binding site [chemical binding]; other site 930782004275 dimer interface [polypeptide binding]; other site 930782004276 substrate binding site [chemical binding]; other site 930782004277 hypothetical protein; Validated; Region: PRK00110 930782004278 prephenate dehydratase; Provisional; Region: PRK11898 930782004279 Prephenate dehydratase; Region: PDT; pfam00800 930782004280 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 930782004281 putative L-Phe binding site [chemical binding]; other site 930782004282 GTPase CgtA; Reviewed; Region: obgE; PRK12297 930782004283 GTP1/OBG; Region: GTP1_OBG; pfam01018 930782004284 Obg GTPase; Region: Obg; cd01898 930782004285 G1 box; other site 930782004286 GTP/Mg2+ binding site [chemical binding]; other site 930782004287 Switch I region; other site 930782004288 G2 box; other site 930782004289 G3 box; other site 930782004290 Switch II region; other site 930782004291 G4 box; other site 930782004292 G5 box; other site 930782004293 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 930782004294 glycerol kinase; Provisional; Region: glpK; PRK00047 930782004295 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 930782004296 N- and C-terminal domain interface [polypeptide binding]; other site 930782004297 active site 930782004298 MgATP binding site [chemical binding]; other site 930782004299 catalytic site [active] 930782004300 metal binding site [ion binding]; metal-binding site 930782004301 glycerol binding site [chemical binding]; other site 930782004302 homotetramer interface [polypeptide binding]; other site 930782004303 homodimer interface [polypeptide binding]; other site 930782004304 FBP binding site [chemical binding]; other site 930782004305 protein IIAGlc interface [polypeptide binding]; other site 930782004306 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 930782004307 amphipathic channel; other site 930782004308 Asn-Pro-Ala signature motifs; other site 930782004309 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 930782004310 hypothetical protein; Provisional; Region: PRK14553 930782004311 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 930782004312 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 930782004313 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 930782004314 homodimer interface [polypeptide binding]; other site 930782004315 oligonucleotide binding site [chemical binding]; other site 930782004316 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 930782004317 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 930782004318 Switch I; other site 930782004319 Switch II; other site 930782004320 septum formation inhibitor; Reviewed; Region: minC; PRK00513 930782004321 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 930782004322 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 930782004323 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 930782004324 Protein of unknown function (DUF972); Region: DUF972; pfam06156 930782004325 rod shape-determining protein MreC; Region: MreC; pfam04085 930782004326 rod shape-determining protein MreB; Provisional; Region: PRK13927 930782004327 MreB and similar proteins; Region: MreB_like; cd10225 930782004328 nucleotide binding site [chemical binding]; other site 930782004329 Mg binding site [ion binding]; other site 930782004330 putative protofilament interaction site [polypeptide binding]; other site 930782004331 RodZ interaction site [polypeptide binding]; other site 930782004332 hypothetical protein; Reviewed; Region: PRK00024 930782004333 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 930782004334 MPN+ (JAMM) motif; other site 930782004335 Zinc-binding site [ion binding]; other site 930782004336 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 930782004337 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 930782004338 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 930782004339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930782004340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930782004341 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 930782004342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930782004343 active site 930782004344 HIGH motif; other site 930782004345 nucleotide binding site [chemical binding]; other site 930782004346 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930782004347 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 930782004348 active site 930782004349 KMSKS motif; other site 930782004350 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 930782004351 tRNA binding surface [nucleotide binding]; other site 930782004352 anticodon binding site; other site 930782004353 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 930782004354 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 930782004355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930782004356 inhibitor-cofactor binding pocket; inhibition site 930782004357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004358 catalytic residue [active] 930782004359 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 930782004360 dimer interface [polypeptide binding]; other site 930782004361 active site 930782004362 Schiff base residues; other site 930782004363 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 930782004364 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 930782004365 active site 930782004366 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 930782004367 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 930782004368 domain interfaces; other site 930782004369 active site 930782004370 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 930782004371 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 930782004372 tRNA; other site 930782004373 putative tRNA binding site [nucleotide binding]; other site 930782004374 putative NADP binding site [chemical binding]; other site 930782004375 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 930782004376 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 930782004377 G1 box; other site 930782004378 GTP/Mg2+ binding site [chemical binding]; other site 930782004379 Switch I region; other site 930782004380 G2 box; other site 930782004381 G3 box; other site 930782004382 Switch II region; other site 930782004383 G4 box; other site 930782004384 G5 box; other site 930782004385 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 930782004386 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 930782004387 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 930782004388 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 930782004389 active site 930782004390 dimer interface [polypeptide binding]; other site 930782004391 motif 1; other site 930782004392 motif 2; other site 930782004393 motif 3; other site 930782004394 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 930782004395 anticodon binding site; other site 930782004396 primosomal protein DnaI; Reviewed; Region: PRK08939 930782004397 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 930782004398 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 930782004399 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930782004400 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 930782004401 ATP cone domain; Region: ATP-cone; pfam03477 930782004402 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 930782004403 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 930782004404 CoA-binding site [chemical binding]; other site 930782004405 ATP-binding [chemical binding]; other site 930782004406 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 930782004407 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 930782004408 DNA binding site [nucleotide binding] 930782004409 catalytic residue [active] 930782004410 H2TH interface [polypeptide binding]; other site 930782004411 putative catalytic residues [active] 930782004412 turnover-facilitating residue; other site 930782004413 intercalation triad [nucleotide binding]; other site 930782004414 8OG recognition residue [nucleotide binding]; other site 930782004415 putative reading head residues; other site 930782004416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 930782004417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930782004418 DNA polymerase I; Provisional; Region: PRK05755 930782004419 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930782004420 active site 930782004421 metal binding site 1 [ion binding]; metal-binding site 930782004422 putative 5' ssDNA interaction site; other site 930782004423 metal binding site 3; metal-binding site 930782004424 metal binding site 2 [ion binding]; metal-binding site 930782004425 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930782004426 putative DNA binding site [nucleotide binding]; other site 930782004427 putative metal binding site [ion binding]; other site 930782004428 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 930782004429 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 930782004430 active site 930782004431 DNA binding site [nucleotide binding] 930782004432 catalytic site [active] 930782004433 isocitrate dehydrogenase; Reviewed; Region: PRK07006 930782004434 isocitrate dehydrogenase; Validated; Region: PRK07362 930782004435 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 930782004436 dimer interface [polypeptide binding]; other site 930782004437 Citrate synthase; Region: Citrate_synt; pfam00285 930782004438 active site 930782004439 citrylCoA binding site [chemical binding]; other site 930782004440 oxalacetate/citrate binding site [chemical binding]; other site 930782004441 coenzyme A binding site [chemical binding]; other site 930782004442 catalytic triad [active] 930782004443 Protein of unknown function (DUF441); Region: DUF441; pfam04284 930782004444 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 930782004445 pyruvate kinase; Provisional; Region: PRK06354 930782004446 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 930782004447 domain interfaces; other site 930782004448 active site 930782004449 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 930782004450 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 930782004451 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 930782004452 active site 930782004453 ADP/pyrophosphate binding site [chemical binding]; other site 930782004454 dimerization interface [polypeptide binding]; other site 930782004455 allosteric effector site; other site 930782004456 fructose-1,6-bisphosphate binding site; other site 930782004457 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 930782004458 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 930782004459 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 930782004460 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 930782004461 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 930782004462 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 930782004463 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 930782004464 active site 930782004465 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 930782004466 generic binding surface I; other site 930782004467 generic binding surface II; other site 930782004468 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 930782004469 DHH family; Region: DHH; pfam01368 930782004470 DHHA1 domain; Region: DHHA1; pfam02272 930782004471 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 930782004472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 930782004473 DNA-binding site [nucleotide binding]; DNA binding site 930782004474 DRTGG domain; Region: DRTGG; pfam07085 930782004475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 930782004476 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 930782004477 active site 2 [active] 930782004478 active site 1 [active] 930782004479 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 930782004480 metal-dependent hydrolase; Provisional; Region: PRK00685 930782004481 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 930782004482 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 930782004483 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 930782004484 active site 930782004485 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 930782004486 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 930782004487 hexamer interface [polypeptide binding]; other site 930782004488 ligand binding site [chemical binding]; other site 930782004489 putative active site [active] 930782004490 NAD(P) binding site [chemical binding]; other site 930782004491 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930782004492 Ligand Binding Site [chemical binding]; other site 930782004493 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 930782004494 propionate/acetate kinase; Provisional; Region: PRK12379 930782004495 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 930782004496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004497 S-adenosylmethionine binding site [chemical binding]; other site 930782004498 RDD family; Region: RDD; pfam06271 930782004499 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 930782004500 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 930782004501 tandem repeat interface [polypeptide binding]; other site 930782004502 oligomer interface [polypeptide binding]; other site 930782004503 active site residues [active] 930782004504 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 930782004505 ATP-NAD kinase; Region: NAD_kinase; pfam01513 930782004506 ornithine carbamoyltransferase; Provisional; Region: PRK00779 930782004507 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930782004508 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930782004509 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 930782004510 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930782004511 inhibitor-cofactor binding pocket; inhibition site 930782004512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004513 catalytic residue [active] 930782004514 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 930782004515 nucleotide binding site [chemical binding]; other site 930782004516 N-acetyl-L-glutamate binding site [chemical binding]; other site 930782004517 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 930782004518 heterotetramer interface [polypeptide binding]; other site 930782004519 active site pocket [active] 930782004520 cleavage site 930782004521 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 930782004522 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 930782004523 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 930782004524 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 930782004525 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 930782004526 Ligand Binding Site [chemical binding]; other site 930782004527 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930782004528 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930782004529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782004530 catalytic residue [active] 930782004531 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 930782004532 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 930782004533 GAF domain; Region: GAF_2; pfam13185 930782004534 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 930782004535 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 930782004536 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782004537 RNA binding surface [nucleotide binding]; other site 930782004538 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 930782004539 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 930782004540 active site 930782004541 HIGH motif; other site 930782004542 dimer interface [polypeptide binding]; other site 930782004543 KMSKS motif; other site 930782004544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782004545 RNA binding surface [nucleotide binding]; other site 930782004546 catabolite control protein A; Region: ccpA; TIGR01481 930782004547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782004548 DNA binding site [nucleotide binding] 930782004549 domain linker motif; other site 930782004550 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 930782004551 dimerization interface [polypeptide binding]; other site 930782004552 effector binding site; other site 930782004553 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 930782004554 Chorismate mutase type II; Region: CM_2; cl00693 930782004555 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 930782004556 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 930782004557 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 930782004558 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930782004559 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930782004560 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 930782004561 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 930782004562 dimer interface [polypeptide binding]; other site 930782004563 decamer (pentamer of dimers) interface [polypeptide binding]; other site 930782004564 catalytic triad [active] 930782004565 peroxidatic and resolving cysteines [active] 930782004566 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 930782004567 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930782004568 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930782004569 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930782004570 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930782004571 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930782004572 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 930782004573 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 930782004574 putative tRNA-binding site [nucleotide binding]; other site 930782004575 hypothetical protein; Provisional; Region: PRK13668 930782004576 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782004577 catalytic residues [active] 930782004578 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 930782004579 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 930782004580 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 930782004581 oligomer interface [polypeptide binding]; other site 930782004582 active site 930782004583 metal binding site [ion binding]; metal-binding site 930782004584 Predicted small secreted protein [Function unknown]; Region: COG5584 930782004585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 930782004586 putative homodimer interface [polypeptide binding]; other site 930782004587 putative homotetramer interface [polypeptide binding]; other site 930782004588 putative allosteric switch controlling residues; other site 930782004589 putative metal binding site [ion binding]; other site 930782004590 putative homodimer-homodimer interface [polypeptide binding]; other site 930782004591 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782004592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004593 S-adenosylmethionine binding site [chemical binding]; other site 930782004594 Phosphotransferase enzyme family; Region: APH; pfam01636 930782004595 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930782004596 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930782004597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782004598 putative substrate translocation pore; other site 930782004599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782004600 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782004601 MarR family; Region: MarR; pfam01047 930782004602 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930782004603 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 930782004604 homodimer interface [polypeptide binding]; other site 930782004605 substrate-cofactor binding pocket; other site 930782004606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004607 catalytic residue [active] 930782004608 dipeptidase PepV; Reviewed; Region: PRK07318 930782004609 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 930782004610 active site 930782004611 metal binding site [ion binding]; metal-binding site 930782004612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 930782004613 nudix motif; other site 930782004614 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 930782004615 putative substrate binding site [chemical binding]; other site 930782004616 putative ATP binding site [chemical binding]; other site 930782004617 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930782004618 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930782004619 active site 930782004620 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930782004621 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930782004622 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930782004623 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930782004624 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 930782004625 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 930782004626 substrate binding site [chemical binding]; other site 930782004627 active site 930782004628 catalytic residues [active] 930782004629 heterodimer interface [polypeptide binding]; other site 930782004630 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 930782004631 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 930782004632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004633 catalytic residue [active] 930782004634 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 930782004635 active site 930782004636 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 930782004637 active site 930782004638 ribulose/triose binding site [chemical binding]; other site 930782004639 phosphate binding site [ion binding]; other site 930782004640 substrate (anthranilate) binding pocket [chemical binding]; other site 930782004641 product (indole) binding pocket [chemical binding]; other site 930782004642 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 930782004643 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930782004644 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930782004645 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930782004646 Glutamine amidotransferase class-I; Region: GATase; pfam00117 930782004647 glutamine binding [chemical binding]; other site 930782004648 catalytic triad [active] 930782004649 anthranilate synthase component I; Provisional; Region: PRK13570 930782004650 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 930782004651 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930782004652 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 930782004653 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 930782004654 putative catalytic cysteine [active] 930782004655 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 930782004656 putative active site [active] 930782004657 metal binding site [ion binding]; metal-binding site 930782004658 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930782004659 dimer interface [polypeptide binding]; other site 930782004660 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782004661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782004662 Walker A/P-loop; other site 930782004663 ATP binding site [chemical binding]; other site 930782004664 Q-loop/lid; other site 930782004665 ABC transporter signature motif; other site 930782004666 Walker B; other site 930782004667 D-loop; other site 930782004668 H-loop/switch region; other site 930782004669 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930782004670 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 930782004671 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930782004672 putative dimer interface [polypeptide binding]; other site 930782004673 catalytic triad [active] 930782004674 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 930782004675 aconitate hydratase; Validated; Region: PRK09277 930782004676 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 930782004677 substrate binding site [chemical binding]; other site 930782004678 ligand binding site [chemical binding]; other site 930782004679 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 930782004680 substrate binding site [chemical binding]; other site 930782004681 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782004682 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 930782004683 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 930782004684 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782004685 ATP binding site [chemical binding]; other site 930782004686 putative Mg++ binding site [ion binding]; other site 930782004687 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782004688 nucleotide binding region [chemical binding]; other site 930782004689 ATP-binding site [chemical binding]; other site 930782004690 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 930782004691 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 930782004692 Walker A/P-loop; other site 930782004693 ATP binding site [chemical binding]; other site 930782004694 Q-loop/lid; other site 930782004695 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 930782004696 ABC transporter signature motif; other site 930782004697 Walker B; other site 930782004698 D-loop; other site 930782004699 H-loop/switch region; other site 930782004700 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930782004701 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930782004702 active site 930782004703 metal binding site [ion binding]; metal-binding site 930782004704 DNA binding site [nucleotide binding] 930782004705 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 930782004706 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 930782004707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 930782004708 putative acyl-acceptor binding pocket; other site 930782004709 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 930782004710 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782004711 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782004712 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 930782004713 Walker A/P-loop; other site 930782004714 ATP binding site [chemical binding]; other site 930782004715 Q-loop/lid; other site 930782004716 ABC transporter signature motif; other site 930782004717 Walker B; other site 930782004718 D-loop; other site 930782004719 H-loop/switch region; other site 930782004720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782004721 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 930782004722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782004723 Walker A/P-loop; other site 930782004724 ATP binding site [chemical binding]; other site 930782004725 Q-loop/lid; other site 930782004726 ABC transporter signature motif; other site 930782004727 Walker B; other site 930782004728 D-loop; other site 930782004729 H-loop/switch region; other site 930782004730 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 930782004731 active site 930782004732 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930782004733 elongation factor Ts; Provisional; Region: tsf; PRK09377 930782004734 UBA/TS-N domain; Region: UBA; pfam00627 930782004735 Elongation factor TS; Region: EF_TS; pfam00889 930782004736 Elongation factor TS; Region: EF_TS; pfam00889 930782004737 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 930782004738 rRNA interaction site [nucleotide binding]; other site 930782004739 S8 interaction site; other site 930782004740 putative laminin-1 binding site; other site 930782004741 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930782004742 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 930782004743 active site turn [active] 930782004744 phosphorylation site [posttranslational modification] 930782004745 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930782004746 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 930782004747 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 930782004748 putative active site [active] 930782004749 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782004750 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782004751 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782004752 putative active site [active] 930782004753 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 930782004754 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 930782004755 HIGH motif; other site 930782004756 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 930782004757 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 930782004758 active site 930782004759 KMSKS motif; other site 930782004760 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 930782004761 tRNA binding surface [nucleotide binding]; other site 930782004762 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 930782004763 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 930782004764 FeS/SAM binding site; other site 930782004765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004766 S-adenosylmethionine binding site [chemical binding]; other site 930782004767 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 930782004768 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 930782004769 active site 930782004770 dimer interface [polypeptide binding]; other site 930782004771 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 930782004772 Ligand Binding Site [chemical binding]; other site 930782004773 Molecular Tunnel; other site 930782004774 S-adenosylmethionine synthetase; Validated; Region: PRK05250 930782004775 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 930782004776 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 930782004777 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 930782004778 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 930782004779 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 930782004780 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930782004781 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782004782 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 930782004783 NAD binding site [chemical binding]; other site 930782004784 dimer interface [polypeptide binding]; other site 930782004785 substrate binding site [chemical binding]; other site 930782004786 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 930782004787 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 930782004788 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 930782004789 nudix motif; other site 930782004790 Uncharacterized conserved protein [Function unknown]; Region: COG0759 930782004791 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 930782004792 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 930782004793 metal binding site [ion binding]; metal-binding site 930782004794 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 930782004795 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 930782004796 acyl-activating enzyme (AAE) consensus motif; other site 930782004797 putative AMP binding site [chemical binding]; other site 930782004798 putative active site [active] 930782004799 putative CoA binding site [chemical binding]; other site 930782004800 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 930782004801 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 930782004802 substrate binding site [chemical binding]; other site 930782004803 oxyanion hole (OAH) forming residues; other site 930782004804 trimer interface [polypeptide binding]; other site 930782004805 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782004806 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 930782004807 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 930782004808 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 930782004809 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 930782004810 dimer interface [polypeptide binding]; other site 930782004811 tetramer interface [polypeptide binding]; other site 930782004812 PYR/PP interface [polypeptide binding]; other site 930782004813 TPP binding site [chemical binding]; other site 930782004814 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 930782004815 TPP-binding site; other site 930782004816 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 930782004817 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930782004818 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 930782004819 UbiA prenyltransferase family; Region: UbiA; pfam01040 930782004820 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 930782004821 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 930782004822 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 930782004823 FAD binding site [chemical binding]; other site 930782004824 cystathionine beta-lyase; Provisional; Region: PRK08064 930782004825 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930782004826 homodimer interface [polypeptide binding]; other site 930782004827 substrate-cofactor binding pocket; other site 930782004828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004829 catalytic residue [active] 930782004830 cystathionine gamma-synthase; Reviewed; Region: PRK08247 930782004831 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 930782004832 homodimer interface [polypeptide binding]; other site 930782004833 substrate-cofactor binding pocket; other site 930782004834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004835 catalytic residue [active] 930782004836 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 930782004837 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 930782004838 THF binding site; other site 930782004839 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 930782004840 substrate binding site [chemical binding]; other site 930782004841 THF binding site; other site 930782004842 zinc-binding site [ion binding]; other site 930782004843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782004844 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782004845 putative substrate translocation pore; other site 930782004846 ferric uptake regulator; Provisional; Region: fur; PRK09462 930782004847 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930782004848 metal binding site 2 [ion binding]; metal-binding site 930782004849 putative DNA binding helix; other site 930782004850 metal binding site 1 [ion binding]; metal-binding site 930782004851 dimer interface [polypeptide binding]; other site 930782004852 structural Zn2+ binding site [ion binding]; other site 930782004853 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930782004854 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930782004855 NAD binding site [chemical binding]; other site 930782004856 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 930782004857 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 930782004858 inhibitor-cofactor binding pocket; inhibition site 930782004859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782004860 catalytic residue [active] 930782004861 Predicted membrane protein [Function unknown]; Region: COG4129 930782004862 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930782004863 hypothetical protein; Provisional; Region: PRK13662 930782004864 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 930782004865 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 930782004866 putative NAD(P) binding site [chemical binding]; other site 930782004867 active site 930782004868 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 930782004869 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930782004870 minor groove reading motif; other site 930782004871 helix-hairpin-helix signature motif; other site 930782004872 substrate binding pocket [chemical binding]; other site 930782004873 active site 930782004874 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 930782004875 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 930782004876 DNA binding and oxoG recognition site [nucleotide binding] 930782004877 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 930782004878 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 930782004879 trimer interface [polypeptide binding]; other site 930782004880 active site 930782004881 WVELL protein; Region: WVELL; pfam14043 930782004882 recombination regulator RecX; Provisional; Region: recX; PRK14135 930782004883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930782004884 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 930782004885 NAD(P) binding site [chemical binding]; other site 930782004886 active site 930782004887 Predicted integral membrane protein [Function unknown]; Region: COG0392 930782004888 Uncharacterized conserved protein [Function unknown]; Region: COG2898 930782004889 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 930782004890 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 930782004891 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930782004892 Cation efflux family; Region: Cation_efflux; pfam01545 930782004893 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930782004894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 930782004895 PAS fold; Region: PAS_4; pfam08448 930782004896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 930782004897 putative active site [active] 930782004898 heme pocket [chemical binding]; other site 930782004899 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 930782004900 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 930782004901 dimer interface [polypeptide binding]; other site 930782004902 putative CheW interface [polypeptide binding]; other site 930782004903 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 930782004904 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 930782004905 dimer interface [polypeptide binding]; other site 930782004906 active site 930782004907 Mn binding site [ion binding]; other site 930782004908 TRAM domain; Region: TRAM; cl01282 930782004909 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 930782004910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004911 S-adenosylmethionine binding site [chemical binding]; other site 930782004912 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 930782004913 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 930782004914 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 930782004915 Substrate-binding site [chemical binding]; other site 930782004916 Substrate specificity [chemical binding]; other site 930782004917 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 930782004918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 930782004919 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 930782004920 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 930782004921 active site 930782004922 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 930782004923 flavodoxin, short chain; Region: flav_short; TIGR01753 930782004924 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 930782004925 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 930782004926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782004927 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782004928 putative substrate translocation pore; other site 930782004929 rod-share determining protein MreBH; Provisional; Region: PRK13929 930782004930 MreB and similar proteins; Region: MreB_like; cd10225 930782004931 nucleotide binding site [chemical binding]; other site 930782004932 Mg binding site [ion binding]; other site 930782004933 putative protofilament interaction site [polypeptide binding]; other site 930782004934 RodZ interaction site [polypeptide binding]; other site 930782004935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782004936 S-adenosylmethionine binding site [chemical binding]; other site 930782004937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782004938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782004939 Uncharacterized conserved protein [Function unknown]; Region: COG3589 930782004940 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 930782004941 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782004942 methionine cluster; other site 930782004943 active site 930782004944 phosphorylation site [posttranslational modification] 930782004945 metal binding site [ion binding]; metal-binding site 930782004946 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782004947 active site 930782004948 P-loop; other site 930782004949 phosphorylation site [posttranslational modification] 930782004950 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 930782004951 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 930782004952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782004953 Walker A motif; other site 930782004954 ATP binding site [chemical binding]; other site 930782004955 Walker B motif; other site 930782004956 arginine finger; other site 930782004957 Transcriptional antiterminator [Transcription]; Region: COG3933 930782004958 PRD domain; Region: PRD; pfam00874 930782004959 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782004960 active pocket/dimerization site; other site 930782004961 active site 930782004962 phosphorylation site [posttranslational modification] 930782004963 PRD domain; Region: PRD; pfam00874 930782004964 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930782004965 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782004966 ATP binding site [chemical binding]; other site 930782004967 putative Mg++ binding site [ion binding]; other site 930782004968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782004969 nucleotide binding region [chemical binding]; other site 930782004970 ATP-binding site [chemical binding]; other site 930782004971 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930782004972 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782004973 Walker A/P-loop; other site 930782004974 ATP binding site [chemical binding]; other site 930782004975 Q-loop/lid; other site 930782004976 ABC transporter signature motif; other site 930782004977 Walker B; other site 930782004978 D-loop; other site 930782004979 H-loop/switch region; other site 930782004980 Predicted transcriptional regulators [Transcription]; Region: COG1725 930782004981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782004982 DNA-binding site [nucleotide binding]; DNA binding site 930782004983 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782004984 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782004985 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782004986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782004987 DNA binding site [nucleotide binding] 930782004988 domain linker motif; other site 930782004989 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930782004990 dimerization interface [polypeptide binding]; other site 930782004991 ligand binding site [chemical binding]; other site 930782004992 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 930782004993 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 930782004994 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930782004995 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930782004996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930782004997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782004999 dimer interface [polypeptide binding]; other site 930782005000 conserved gate region; other site 930782005001 putative PBP binding loops; other site 930782005002 ABC-ATPase subunit interface; other site 930782005003 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782005004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782005005 dimer interface [polypeptide binding]; other site 930782005006 conserved gate region; other site 930782005007 putative PBP binding loops; other site 930782005008 ABC-ATPase subunit interface; other site 930782005009 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 930782005010 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 930782005011 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 930782005012 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 930782005013 active site 930782005014 dimer interface [polypeptide binding]; other site 930782005015 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 930782005016 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 930782005017 active site 930782005018 FMN binding site [chemical binding]; other site 930782005019 substrate binding site [chemical binding]; other site 930782005020 3Fe-4S cluster binding site [ion binding]; other site 930782005021 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 930782005022 domain interface; other site 930782005023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782005024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782005025 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930782005026 putative dimerization interface [polypeptide binding]; other site 930782005027 Predicted acetyltransferase [General function prediction only]; Region: COG3153 930782005028 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 930782005029 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 930782005030 putative active site [active] 930782005031 metal binding site [ion binding]; metal-binding site 930782005032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930782005033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930782005034 substrate binding pocket [chemical binding]; other site 930782005035 membrane-bound complex binding site; other site 930782005036 hinge residues; other site 930782005037 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782005038 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782005039 Walker A/P-loop; other site 930782005040 ATP binding site [chemical binding]; other site 930782005041 Q-loop/lid; other site 930782005042 ABC transporter signature motif; other site 930782005043 Walker B; other site 930782005044 D-loop; other site 930782005045 H-loop/switch region; other site 930782005046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782005047 dimer interface [polypeptide binding]; other site 930782005048 conserved gate region; other site 930782005049 putative PBP binding loops; other site 930782005050 ABC-ATPase subunit interface; other site 930782005051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 930782005052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 930782005053 dimer interface [polypeptide binding]; other site 930782005054 phosphorylation site [posttranslational modification] 930782005055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782005056 ATP binding site [chemical binding]; other site 930782005057 Mg2+ binding site [ion binding]; other site 930782005058 G-X-G motif; other site 930782005059 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 930782005060 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930782005061 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 930782005062 active site 930782005063 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 930782005064 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 930782005065 putative NAD(P) binding site [chemical binding]; other site 930782005066 active site 930782005067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782005068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782005069 active site 930782005070 phosphorylation site [posttranslational modification] 930782005071 intermolecular recognition site; other site 930782005072 dimerization interface [polypeptide binding]; other site 930782005073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782005074 DNA binding site [nucleotide binding] 930782005075 FtsX-like permease family; Region: FtsX; pfam02687 930782005076 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782005077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782005078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782005079 Walker A/P-loop; other site 930782005080 ATP binding site [chemical binding]; other site 930782005081 Q-loop/lid; other site 930782005082 ABC transporter signature motif; other site 930782005083 Walker B; other site 930782005084 D-loop; other site 930782005085 H-loop/switch region; other site 930782005086 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 930782005087 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 930782005088 ADP binding site [chemical binding]; other site 930782005089 magnesium binding site [ion binding]; other site 930782005090 putative shikimate binding site; other site 930782005091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 930782005092 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 930782005093 TRAM domain; Region: TRAM; pfam01938 930782005094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782005095 S-adenosylmethionine binding site [chemical binding]; other site 930782005096 putative lipid kinase; Reviewed; Region: PRK13337 930782005097 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930782005098 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 930782005099 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 930782005100 GatB domain; Region: GatB_Yqey; smart00845 930782005101 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 930782005102 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 930782005103 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 930782005104 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 930782005105 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 930782005106 putative dimer interface [polypeptide binding]; other site 930782005107 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 930782005108 putative dimer interface [polypeptide binding]; other site 930782005109 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 930782005110 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 930782005111 nucleotide binding pocket [chemical binding]; other site 930782005112 K-X-D-G motif; other site 930782005113 catalytic site [active] 930782005114 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 930782005115 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 930782005116 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 930782005117 Dimer interface [polypeptide binding]; other site 930782005118 BRCT sequence motif; other site 930782005119 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 930782005120 Part of AAA domain; Region: AAA_19; pfam13245 930782005121 Family description; Region: UvrD_C_2; pfam13538 930782005122 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 930782005123 PcrB family; Region: PcrB; pfam01884 930782005124 substrate binding site [chemical binding]; other site 930782005125 putative active site [active] 930782005126 dimer interface [polypeptide binding]; other site 930782005127 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 930782005128 Na2 binding site [ion binding]; other site 930782005129 putative substrate binding site 1 [chemical binding]; other site 930782005130 Na binding site 1 [ion binding]; other site 930782005131 putative substrate binding site 2 [chemical binding]; other site 930782005132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 930782005133 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 930782005134 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 930782005135 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 930782005136 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 930782005137 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 930782005138 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 930782005139 purine monophosphate binding site [chemical binding]; other site 930782005140 dimer interface [polypeptide binding]; other site 930782005141 putative catalytic residues [active] 930782005142 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 930782005143 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 930782005144 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 930782005145 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 930782005146 active site 930782005147 substrate binding site [chemical binding]; other site 930782005148 cosubstrate binding site; other site 930782005149 catalytic site [active] 930782005150 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 930782005151 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 930782005152 dimerization interface [polypeptide binding]; other site 930782005153 putative ATP binding site [chemical binding]; other site 930782005154 amidophosphoribosyltransferase; Provisional; Region: PRK06781 930782005155 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 930782005156 active site 930782005157 tetramer interface [polypeptide binding]; other site 930782005158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782005159 active site 930782005160 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 930782005161 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 930782005162 dimerization interface [polypeptide binding]; other site 930782005163 ATP binding site [chemical binding]; other site 930782005164 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 930782005165 dimerization interface [polypeptide binding]; other site 930782005166 ATP binding site [chemical binding]; other site 930782005167 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 930782005168 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 930782005169 putative active site [active] 930782005170 catalytic triad [active] 930782005171 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 930782005172 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 930782005173 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 930782005174 ATP binding site [chemical binding]; other site 930782005175 active site 930782005176 substrate binding site [chemical binding]; other site 930782005177 adenylosuccinate lyase; Provisional; Region: PRK07492 930782005178 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 930782005179 tetramer interface [polypeptide binding]; other site 930782005180 active site 930782005181 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 930782005182 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 930782005183 NAD binding site [chemical binding]; other site 930782005184 ATP-grasp domain; Region: ATP-grasp; pfam02222 930782005185 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 930782005186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 930782005187 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782005188 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 930782005189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782005190 Zn2+ binding site [ion binding]; other site 930782005191 Mg2+ binding site [ion binding]; other site 930782005192 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930782005193 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930782005194 Walker A/P-loop; other site 930782005195 ATP binding site [chemical binding]; other site 930782005196 Q-loop/lid; other site 930782005197 ABC transporter signature motif; other site 930782005198 Walker B; other site 930782005199 D-loop; other site 930782005200 H-loop/switch region; other site 930782005201 peptidase T; Region: peptidase-T; TIGR01882 930782005202 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 930782005203 metal binding site [ion binding]; metal-binding site 930782005204 dimer interface [polypeptide binding]; other site 930782005205 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 930782005206 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 930782005207 active site 930782005208 putative catalytic site [active] 930782005209 DNA binding site [nucleotide binding] 930782005210 putative phosphate binding site [ion binding]; other site 930782005211 metal binding site A [ion binding]; metal-binding site 930782005212 AP binding site [nucleotide binding]; other site 930782005213 metal binding site B [ion binding]; metal-binding site 930782005214 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 930782005215 23S rRNA binding site [nucleotide binding]; other site 930782005216 L21 binding site [polypeptide binding]; other site 930782005217 L13 binding site [polypeptide binding]; other site 930782005218 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 930782005219 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 930782005220 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 930782005221 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 930782005222 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782005223 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782005224 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782005225 Substrate binding site [chemical binding]; other site 930782005226 Leucine rich repeat; Region: LRR_8; pfam13855 930782005227 LRR adjacent; Region: LRR_adjacent; pfam08191 930782005228 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 930782005229 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930782005230 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930782005231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782005232 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 930782005233 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 930782005234 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 930782005235 RimM N-terminal domain; Region: RimM; pfam01782 930782005236 PRC-barrel domain; Region: PRC; pfam05239 930782005237 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 930782005238 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 930782005239 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 930782005240 catalytic triad [active] 930782005241 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 930782005242 KH domain; Region: KH_4; pfam13083 930782005243 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 930782005244 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 930782005245 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 930782005246 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 930782005247 signal recognition particle protein; Provisional; Region: PRK10867 930782005248 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 930782005249 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930782005250 P loop; other site 930782005251 GTP binding site [chemical binding]; other site 930782005252 Signal peptide binding domain; Region: SRP_SPB; pfam02978 930782005253 putative DNA-binding protein; Validated; Region: PRK00118 930782005254 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 930782005255 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 930782005256 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 930782005257 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 930782005258 P loop; other site 930782005259 GTP binding site [chemical binding]; other site 930782005260 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 930782005261 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930782005262 Walker A/P-loop; other site 930782005263 ATP binding site [chemical binding]; other site 930782005264 Q-loop/lid; other site 930782005265 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 930782005266 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 930782005267 linker region; other site 930782005268 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 930782005269 ABC transporter signature motif; other site 930782005270 Walker B; other site 930782005271 D-loop; other site 930782005272 H-loop/switch region; other site 930782005273 ribonuclease III; Reviewed; Region: rnc; PRK00102 930782005274 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 930782005275 dimerization interface [polypeptide binding]; other site 930782005276 active site 930782005277 metal binding site [ion binding]; metal-binding site 930782005278 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 930782005279 dsRNA binding site [nucleotide binding]; other site 930782005280 acyl carrier protein; Provisional; Region: acpP; PRK00982 930782005281 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930782005282 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 930782005283 NAD(P) binding site [chemical binding]; other site 930782005284 homotetramer interface [polypeptide binding]; other site 930782005285 homodimer interface [polypeptide binding]; other site 930782005286 active site 930782005287 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 930782005288 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 930782005289 putative phosphate acyltransferase; Provisional; Region: PRK05331 930782005290 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 930782005291 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 930782005292 active site 2 [active] 930782005293 active site 1 [active] 930782005294 Y-family of DNA polymerases; Region: PolY; cl12025 930782005295 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 930782005296 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 930782005297 generic binding surface II; other site 930782005298 ssDNA binding site; other site 930782005299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782005300 ATP binding site [chemical binding]; other site 930782005301 putative Mg++ binding site [ion binding]; other site 930782005302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782005303 nucleotide binding region [chemical binding]; other site 930782005304 ATP-binding site [chemical binding]; other site 930782005305 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 930782005306 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 930782005307 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 930782005308 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 930782005309 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 930782005310 putative L-serine binding site [chemical binding]; other site 930782005311 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 930782005312 DAK2 domain; Region: Dak2; pfam02734 930782005313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 930782005314 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 930782005315 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 930782005316 Thiamine pyrophosphokinase; Region: TPK; cd07995 930782005317 active site 930782005318 dimerization interface [polypeptide binding]; other site 930782005319 thiamine binding site [chemical binding]; other site 930782005320 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930782005321 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930782005322 substrate binding site [chemical binding]; other site 930782005323 hexamer interface [polypeptide binding]; other site 930782005324 metal binding site [ion binding]; metal-binding site 930782005325 GTPase RsgA; Reviewed; Region: PRK00098 930782005326 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 930782005327 RNA binding site [nucleotide binding]; other site 930782005328 homodimer interface [polypeptide binding]; other site 930782005329 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 930782005330 GTPase/Zn-binding domain interface [polypeptide binding]; other site 930782005331 GTP/Mg2+ binding site [chemical binding]; other site 930782005332 G4 box; other site 930782005333 G1 box; other site 930782005334 Switch I region; other site 930782005335 G2 box; other site 930782005336 G3 box; other site 930782005337 Switch II region; other site 930782005338 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 930782005339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 930782005340 active site 930782005341 ATP binding site [chemical binding]; other site 930782005342 substrate binding site [chemical binding]; other site 930782005343 activation loop (A-loop); other site 930782005344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 930782005345 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930782005346 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930782005347 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 930782005348 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 930782005349 Protein phosphatase 2C; Region: PP2C; pfam00481 930782005350 active site 930782005351 16S rRNA methyltransferase B; Provisional; Region: PRK14902 930782005352 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 930782005353 putative RNA binding site [nucleotide binding]; other site 930782005354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782005355 S-adenosylmethionine binding site [chemical binding]; other site 930782005356 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 930782005357 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 930782005358 putative active site [active] 930782005359 substrate binding site [chemical binding]; other site 930782005360 putative cosubstrate binding site; other site 930782005361 catalytic site [active] 930782005362 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 930782005363 substrate binding site [chemical binding]; other site 930782005364 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 930782005365 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782005366 ATP binding site [chemical binding]; other site 930782005367 putative Mg++ binding site [ion binding]; other site 930782005368 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782005369 ATP-binding site [chemical binding]; other site 930782005370 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 930782005371 Flavoprotein; Region: Flavoprotein; pfam02441 930782005372 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 930782005373 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 930782005374 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 930782005375 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 930782005376 catalytic site [active] 930782005377 G-X2-G-X-G-K; other site 930782005378 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 930782005379 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 930782005380 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 930782005381 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 930782005382 Domain of unknown function (DUF814); Region: DUF814; pfam05670 930782005383 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 930782005384 putative NAD(P) binding site [chemical binding]; other site 930782005385 homodimer interface [polypeptide binding]; other site 930782005386 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782005387 active site 930782005388 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 930782005389 active site 930782005390 dimer interface [polypeptide binding]; other site 930782005391 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 930782005392 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 930782005393 heterodimer interface [polypeptide binding]; other site 930782005394 active site 930782005395 FMN binding site [chemical binding]; other site 930782005396 homodimer interface [polypeptide binding]; other site 930782005397 substrate binding site [chemical binding]; other site 930782005398 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 930782005399 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 930782005400 FAD binding pocket [chemical binding]; other site 930782005401 FAD binding motif [chemical binding]; other site 930782005402 phosphate binding motif [ion binding]; other site 930782005403 beta-alpha-beta structure motif; other site 930782005404 NAD binding pocket [chemical binding]; other site 930782005405 Iron coordination center [ion binding]; other site 930782005406 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 930782005407 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930782005408 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 930782005409 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 930782005410 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 930782005411 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930782005412 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 930782005413 IMP binding site; other site 930782005414 dimer interface [polypeptide binding]; other site 930782005415 interdomain contacts; other site 930782005416 partial ornithine binding site; other site 930782005417 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 930782005418 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 930782005419 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 930782005420 catalytic site [active] 930782005421 subunit interface [polypeptide binding]; other site 930782005422 dihydroorotase; Validated; Region: pyrC; PRK09357 930782005423 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 930782005424 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 930782005425 active site 930782005426 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 930782005427 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930782005428 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930782005429 uracil transporter; Provisional; Region: PRK10720 930782005430 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930782005431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782005432 active site 930782005433 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782005434 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930782005435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782005436 RNA binding surface [nucleotide binding]; other site 930782005437 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930782005438 active site 930782005439 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 930782005440 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930782005441 Sulfate transporter family; Region: Sulfate_transp; pfam00916 930782005442 multidrug efflux protein; Reviewed; Region: PRK01766 930782005443 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 930782005444 cation binding site [ion binding]; other site 930782005445 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 930782005446 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 930782005447 metal binding site [ion binding]; metal-binding site 930782005448 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930782005449 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782005450 ABC-ATPase subunit interface; other site 930782005451 dimer interface [polypeptide binding]; other site 930782005452 putative PBP binding regions; other site 930782005453 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 930782005454 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930782005455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782005456 MarR family; Region: MarR; pfam01047 930782005457 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 930782005458 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 930782005459 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 930782005460 protein binding site [polypeptide binding]; other site 930782005461 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 930782005462 Catalytic dyad [active] 930782005463 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 930782005464 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930782005465 metal-binding site [ion binding] 930782005466 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930782005467 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930782005468 metal-binding site [ion binding] 930782005469 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782005470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782005471 motif II; other site 930782005472 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 930782005473 putative homodimer interface [polypeptide binding]; other site 930782005474 putative homotetramer interface [polypeptide binding]; other site 930782005475 putative allosteric switch controlling residues; other site 930782005476 putative metal binding site [ion binding]; other site 930782005477 putative homodimer-homodimer interface [polypeptide binding]; other site 930782005478 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 930782005479 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930782005480 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 930782005481 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 930782005482 hypothetical protein; Provisional; Region: PRK13672 930782005483 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782005484 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782005485 methionine sulfoxide reductase B; Provisional; Region: PRK00222 930782005486 SelR domain; Region: SelR; pfam01641 930782005487 methionine sulfoxide reductase A; Provisional; Region: PRK14054 930782005488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 930782005489 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 930782005490 active site 930782005491 catalytic triad [active] 930782005492 oxyanion hole [active] 930782005493 EDD domain protein, DegV family; Region: DegV; TIGR00762 930782005494 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930782005495 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 930782005496 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 930782005497 HTH domain; Region: HTH_11; pfam08279 930782005498 FOG: CBS domain [General function prediction only]; Region: COG0517 930782005499 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 930782005500 PEP synthetase regulatory protein; Provisional; Region: PRK05339 930782005501 pyruvate phosphate dikinase; Provisional; Region: PRK09279 930782005502 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 930782005503 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 930782005504 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 930782005505 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782005506 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 930782005507 Predicted membrane protein [Function unknown]; Region: COG4129 930782005508 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 930782005509 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 930782005510 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930782005511 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 930782005512 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 930782005513 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 930782005514 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 930782005515 Clostridial hydrophobic W; Region: ChW; pfam07538 930782005516 Clostridial hydrophobic W; Region: ChW; pfam07538 930782005517 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 930782005518 active site 930782005519 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 930782005520 substrate binding site [chemical binding]; other site 930782005521 metal binding site [ion binding]; metal-binding site 930782005522 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 930782005523 Methyltransferase domain; Region: Methyltransf_18; pfam12847 930782005524 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930782005525 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 930782005526 folate binding site [chemical binding]; other site 930782005527 NADP+ binding site [chemical binding]; other site 930782005528 thymidylate synthase; Region: thym_sym; TIGR03284 930782005529 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 930782005530 dimerization interface [polypeptide binding]; other site 930782005531 active site 930782005532 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930782005533 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930782005534 Walker A/P-loop; other site 930782005535 ATP binding site [chemical binding]; other site 930782005536 Q-loop/lid; other site 930782005537 ABC transporter signature motif; other site 930782005538 Walker B; other site 930782005539 D-loop; other site 930782005540 H-loop/switch region; other site 930782005541 ABC transporter; Region: ABC_tran_2; pfam12848 930782005542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782005543 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 930782005544 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 930782005545 Potassium binding sites [ion binding]; other site 930782005546 Cesium cation binding sites [ion binding]; other site 930782005547 manganese transport transcriptional regulator; Provisional; Region: PRK03902 930782005548 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 930782005549 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 930782005550 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930782005551 DNA-binding site [nucleotide binding]; DNA binding site 930782005552 RNA-binding motif; other site 930782005553 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 930782005554 RNA/DNA hybrid binding site [nucleotide binding]; other site 930782005555 active site 930782005556 5'-3' exonuclease; Region: 53EXOc; smart00475 930782005557 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 930782005558 active site 930782005559 metal binding site 1 [ion binding]; metal-binding site 930782005560 putative 5' ssDNA interaction site; other site 930782005561 metal binding site 3; metal-binding site 930782005562 metal binding site 2 [ion binding]; metal-binding site 930782005563 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 930782005564 putative DNA binding site [nucleotide binding]; other site 930782005565 putative metal binding site [ion binding]; other site 930782005566 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 930782005567 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 930782005568 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 930782005569 putative active site [active] 930782005570 xanthine permease; Region: pbuX; TIGR03173 930782005571 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782005572 active site 930782005573 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 930782005574 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 930782005575 active site 930782005576 Zn binding site [ion binding]; other site 930782005577 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 930782005578 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 930782005579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 930782005580 cell division protein GpsB; Provisional; Region: PRK14127 930782005581 DivIVA domain; Region: DivI1A_domain; TIGR03544 930782005582 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 930782005583 hypothetical protein; Provisional; Region: PRK13660 930782005584 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 930782005585 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 930782005586 Transglycosylase; Region: Transgly; pfam00912 930782005587 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930782005588 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930782005589 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 930782005590 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 930782005591 minor groove reading motif; other site 930782005592 helix-hairpin-helix signature motif; other site 930782005593 substrate binding pocket [chemical binding]; other site 930782005594 active site 930782005595 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 930782005596 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 930782005597 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 930782005598 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 930782005599 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 930782005600 putative dimer interface [polypeptide binding]; other site 930782005601 putative anticodon binding site; other site 930782005602 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 930782005603 homodimer interface [polypeptide binding]; other site 930782005604 motif 1; other site 930782005605 motif 2; other site 930782005606 active site 930782005607 motif 3; other site 930782005608 aspartate aminotransferase; Provisional; Region: PRK05764 930782005609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782005610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782005611 homodimer interface [polypeptide binding]; other site 930782005612 catalytic residue [active] 930782005613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 930782005614 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930782005615 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 930782005616 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 930782005617 active site 930782005618 catalytic site [active] 930782005619 substrate binding site [chemical binding]; other site 930782005620 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 930782005621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 930782005622 putative Mg++ binding site [ion binding]; other site 930782005623 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930782005624 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 930782005625 tetramerization interface [polypeptide binding]; other site 930782005626 active site 930782005627 pantoate--beta-alanine ligase; Region: panC; TIGR00018 930782005628 Pantoate-beta-alanine ligase; Region: PanC; cd00560 930782005629 active site 930782005630 ATP-binding site [chemical binding]; other site 930782005631 pantoate-binding site; other site 930782005632 HXXH motif; other site 930782005633 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 930782005634 active site 930782005635 oligomerization interface [polypeptide binding]; other site 930782005636 metal binding site [ion binding]; metal-binding site 930782005637 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782005638 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930782005639 catalytic residues [active] 930782005640 Biotin operon repressor [Transcription]; Region: BirA; COG1654 930782005641 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 930782005642 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 930782005643 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 930782005644 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 930782005645 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 930782005646 active site 930782005647 NTP binding site [chemical binding]; other site 930782005648 metal binding triad [ion binding]; metal-binding site 930782005649 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 930782005650 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 930782005651 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 930782005652 active site 930782005653 dimer interfaces [polypeptide binding]; other site 930782005654 catalytic residues [active] 930782005655 dihydrodipicolinate reductase; Provisional; Region: PRK00048 930782005656 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 930782005657 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 930782005658 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 930782005659 homodimer interface [polypeptide binding]; other site 930782005660 metal binding site [ion binding]; metal-binding site 930782005661 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930782005662 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782005663 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782005664 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782005665 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 930782005666 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930782005667 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930782005668 metal binding site [ion binding]; metal-binding site 930782005669 active site 930782005670 I-site; other site 930782005671 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930782005672 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930782005673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930782005674 metal binding site [ion binding]; metal-binding site 930782005675 active site 930782005676 I-site; other site 930782005677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930782005678 malate dehydrogenase; Provisional; Region: PRK13529 930782005679 Malic enzyme, N-terminal domain; Region: malic; pfam00390 930782005680 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 930782005681 NAD(P) binding pocket [chemical binding]; other site 930782005682 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 930782005683 Beta-lactamase; Region: Beta-lactamase; pfam00144 930782005684 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 930782005685 Pyruvate formate lyase 1; Region: PFL1; cd01678 930782005686 coenzyme A binding site [chemical binding]; other site 930782005687 active site 930782005688 catalytic residues [active] 930782005689 glycine loop; other site 930782005690 HI0933-like protein; Region: HI0933_like; pfam03486 930782005691 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782005692 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 930782005693 Predicted membrane protein [Function unknown]; Region: COG4347 930782005694 hypothetical protein; Provisional; Region: PRK03636 930782005695 UPF0302 domain; Region: UPF0302; pfam08864 930782005696 IDEAL domain; Region: IDEAL; pfam08858 930782005697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930782005698 binding surface 930782005699 TPR motif; other site 930782005700 TPR repeat; Region: TPR_11; pfam13414 930782005701 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782005702 binding surface 930782005703 TPR motif; other site 930782005704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 930782005705 binding surface 930782005706 TPR motif; other site 930782005707 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 930782005708 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 930782005709 hinge; other site 930782005710 active site 930782005711 prephenate dehydrogenase; Validated; Region: PRK06545 930782005712 prephenate dehydrogenase; Validated; Region: PRK08507 930782005713 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 930782005714 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 930782005715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782005716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782005717 homodimer interface [polypeptide binding]; other site 930782005718 catalytic residue [active] 930782005719 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 930782005720 homotrimer interaction site [polypeptide binding]; other site 930782005721 active site 930782005722 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 930782005723 active site 930782005724 dimer interface [polypeptide binding]; other site 930782005725 metal binding site [ion binding]; metal-binding site 930782005726 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 930782005727 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 930782005728 Tetramer interface [polypeptide binding]; other site 930782005729 active site 930782005730 FMN-binding site [chemical binding]; other site 930782005731 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 930782005732 active site 930782005733 multimer interface [polypeptide binding]; other site 930782005734 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930782005735 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930782005736 substrate binding pocket [chemical binding]; other site 930782005737 chain length determination region; other site 930782005738 substrate-Mg2+ binding site; other site 930782005739 catalytic residues [active] 930782005740 aspartate-rich region 1; other site 930782005741 active site lid residues [active] 930782005742 aspartate-rich region 2; other site 930782005743 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 930782005744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782005745 S-adenosylmethionine binding site [chemical binding]; other site 930782005746 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 930782005747 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 930782005748 homodecamer interface [polypeptide binding]; other site 930782005749 GTP cyclohydrolase I; Provisional; Region: PLN03044 930782005750 active site 930782005751 putative catalytic site residues [active] 930782005752 zinc binding site [ion binding]; other site 930782005753 GTP-CH-I/GFRP interaction surface; other site 930782005754 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 930782005755 IHF dimer interface [polypeptide binding]; other site 930782005756 IHF - DNA interface [nucleotide binding]; other site 930782005757 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 930782005758 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 930782005759 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 930782005760 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 930782005761 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 930782005762 GTP-binding protein Der; Reviewed; Region: PRK00093 930782005763 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 930782005764 G1 box; other site 930782005765 GTP/Mg2+ binding site [chemical binding]; other site 930782005766 Switch I region; other site 930782005767 G2 box; other site 930782005768 Switch II region; other site 930782005769 G3 box; other site 930782005770 G4 box; other site 930782005771 G5 box; other site 930782005772 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 930782005773 G1 box; other site 930782005774 GTP/Mg2+ binding site [chemical binding]; other site 930782005775 Switch I region; other site 930782005776 G2 box; other site 930782005777 G3 box; other site 930782005778 Switch II region; other site 930782005779 G4 box; other site 930782005780 G5 box; other site 930782005781 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 930782005782 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 930782005783 RNA binding site [nucleotide binding]; other site 930782005784 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 930782005785 RNA binding site [nucleotide binding]; other site 930782005786 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 930782005787 RNA binding site [nucleotide binding]; other site 930782005788 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930782005789 RNA binding site [nucleotide binding]; other site 930782005790 cytidylate kinase; Provisional; Region: cmk; PRK00023 930782005791 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 930782005792 CMP-binding site; other site 930782005793 The sites determining sugar specificity; other site 930782005794 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 930782005795 active site 930782005796 homotetramer interface [polypeptide binding]; other site 930782005797 homodimer interface [polypeptide binding]; other site 930782005798 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782005799 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 930782005800 DEAD-like helicases superfamily; Region: DEXDc; smart00487 930782005801 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782005802 ATP binding site [chemical binding]; other site 930782005803 putative Mg++ binding site [ion binding]; other site 930782005804 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782005805 nucleotide binding region [chemical binding]; other site 930782005806 ATP-binding site [chemical binding]; other site 930782005807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 930782005808 Predicted membrane protein [Function unknown]; Region: COG3601 930782005809 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930782005810 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 930782005811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782005812 dimerization interface [polypeptide binding]; other site 930782005813 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930782005814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782005815 dimer interface [polypeptide binding]; other site 930782005816 phosphorylation site [posttranslational modification] 930782005817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782005818 ATP binding site [chemical binding]; other site 930782005819 Mg2+ binding site [ion binding]; other site 930782005820 G-X-G motif; other site 930782005821 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782005822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782005823 active site 930782005824 phosphorylation site [posttranslational modification] 930782005825 intermolecular recognition site; other site 930782005826 dimerization interface [polypeptide binding]; other site 930782005827 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782005828 DNA binding site [nucleotide binding] 930782005829 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930782005830 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782005831 RNA binding surface [nucleotide binding]; other site 930782005832 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 930782005833 active site 930782005834 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 930782005835 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 930782005836 diaminopimelate decarboxylase; Region: lysA; TIGR01048 930782005837 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 930782005838 active site 930782005839 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930782005840 substrate binding site [chemical binding]; other site 930782005841 catalytic residues [active] 930782005842 dimer interface [polypeptide binding]; other site 930782005843 purine nucleoside phosphorylase; Provisional; Region: PRK08202 930782005844 phosphopentomutase; Provisional; Region: PRK05362 930782005845 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 930782005846 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 930782005847 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 930782005848 active site 930782005849 Int/Topo IB signature motif; other site 930782005850 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 930782005851 metal binding site 2 [ion binding]; metal-binding site 930782005852 putative DNA binding helix; other site 930782005853 metal binding site 1 [ion binding]; metal-binding site 930782005854 dimer interface [polypeptide binding]; other site 930782005855 structural Zn2+ binding site [ion binding]; other site 930782005856 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930782005857 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782005858 ABC-ATPase subunit interface; other site 930782005859 dimer interface [polypeptide binding]; other site 930782005860 putative PBP binding regions; other site 930782005861 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930782005862 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782005863 ABC-ATPase subunit interface; other site 930782005864 dimer interface [polypeptide binding]; other site 930782005865 putative PBP binding regions; other site 930782005866 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 930782005867 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 930782005868 putative ligand binding residues [chemical binding]; other site 930782005869 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930782005870 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930782005871 Walker A/P-loop; other site 930782005872 ATP binding site [chemical binding]; other site 930782005873 Q-loop/lid; other site 930782005874 ABC transporter signature motif; other site 930782005875 Walker B; other site 930782005876 D-loop; other site 930782005877 H-loop/switch region; other site 930782005878 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930782005879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782005880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782005881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782005882 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 930782005883 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930782005884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782005885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782005886 Walker A/P-loop; other site 930782005887 ATP binding site [chemical binding]; other site 930782005888 Q-loop/lid; other site 930782005889 ABC transporter signature motif; other site 930782005890 Walker B; other site 930782005891 D-loop; other site 930782005892 H-loop/switch region; other site 930782005893 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 930782005894 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 930782005895 dimer interface [polypeptide binding]; other site 930782005896 ADP-ribose binding site [chemical binding]; other site 930782005897 active site 930782005898 nudix motif; other site 930782005899 metal binding site [ion binding]; metal-binding site 930782005900 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 930782005901 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 930782005902 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 930782005903 active site 930782005904 DNA polymerase IV; Validated; Region: PRK02406 930782005905 DNA binding site [nucleotide binding] 930782005906 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 930782005907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 930782005908 NAD(P) binding site [chemical binding]; other site 930782005909 active site 930782005910 ribonuclease Z; Region: RNase_Z; TIGR02651 930782005911 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 930782005912 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 930782005913 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 930782005914 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 930782005915 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930782005916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782005917 Coenzyme A binding pocket [chemical binding]; other site 930782005918 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 930782005919 6-phosphogluconate dehydratase; Region: edd; TIGR01196 930782005920 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 930782005921 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930782005922 PYR/PP interface [polypeptide binding]; other site 930782005923 dimer interface [polypeptide binding]; other site 930782005924 TPP binding site [chemical binding]; other site 930782005925 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930782005926 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 930782005927 TPP-binding site [chemical binding]; other site 930782005928 dimer interface [polypeptide binding]; other site 930782005929 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 930782005930 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 930782005931 putative valine binding site [chemical binding]; other site 930782005932 dimer interface [polypeptide binding]; other site 930782005933 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 930782005934 ketol-acid reductoisomerase; Provisional; Region: PRK05479 930782005935 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 930782005936 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 930782005937 2-isopropylmalate synthase; Validated; Region: PRK00915 930782005938 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 930782005939 active site 930782005940 catalytic residues [active] 930782005941 metal binding site [ion binding]; metal-binding site 930782005942 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 930782005943 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 930782005944 tartrate dehydrogenase; Region: TTC; TIGR02089 930782005945 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 930782005946 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 930782005947 substrate binding site [chemical binding]; other site 930782005948 ligand binding site [chemical binding]; other site 930782005949 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 930782005950 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 930782005951 substrate binding site [chemical binding]; other site 930782005952 threonine dehydratase; Validated; Region: PRK08639 930782005953 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 930782005954 tetramer interface [polypeptide binding]; other site 930782005955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782005956 catalytic residue [active] 930782005957 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 930782005958 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 930782005959 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 930782005960 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 930782005961 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 930782005962 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 930782005963 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782005964 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782005965 DNA binding site [nucleotide binding] 930782005966 domain linker motif; other site 930782005967 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930782005968 dimerization interface [polypeptide binding]; other site 930782005969 ligand binding site [chemical binding]; other site 930782005970 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 930782005971 intersubunit interface [polypeptide binding]; other site 930782005972 active site 930782005973 catalytic residue [active] 930782005974 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930782005975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 930782005976 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930782005977 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782005978 active pocket/dimerization site; other site 930782005979 active site 930782005980 phosphorylation site [posttranslational modification] 930782005981 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930782005982 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 930782005983 putative active site [active] 930782005984 SIS domain; Region: SIS; pfam01380 930782005985 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930782005986 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930782005987 dimer interface [polypeptide binding]; other site 930782005988 active site 930782005989 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930782005990 dimer interface [polypeptide binding]; other site 930782005991 active site 930782005992 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 930782005993 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 930782005994 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930782005995 active site 930782005996 phosphorylation site [posttranslational modification] 930782005997 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782005998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782005999 DNA-binding site [nucleotide binding]; DNA binding site 930782006000 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930782006001 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782006002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782006003 DNA-binding site [nucleotide binding]; DNA binding site 930782006004 UTRA domain; Region: UTRA; pfam07702 930782006005 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782006006 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782006007 active site 930782006008 catalytic tetrad [active] 930782006009 acetolactate synthase; Reviewed; Region: PRK08617 930782006010 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 930782006011 PYR/PP interface [polypeptide binding]; other site 930782006012 dimer interface [polypeptide binding]; other site 930782006013 TPP binding site [chemical binding]; other site 930782006014 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 930782006015 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 930782006016 TPP-binding site [chemical binding]; other site 930782006017 dimer interface [polypeptide binding]; other site 930782006018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782006019 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 930782006020 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 930782006021 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782006022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006023 dimer interface [polypeptide binding]; other site 930782006024 conserved gate region; other site 930782006025 ABC-ATPase subunit interface; other site 930782006026 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930782006027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006028 dimer interface [polypeptide binding]; other site 930782006029 conserved gate region; other site 930782006030 ABC-ATPase subunit interface; other site 930782006031 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 930782006032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782006033 active site 930782006034 phosphorylation site [posttranslational modification] 930782006035 intermolecular recognition site; other site 930782006036 dimerization interface [polypeptide binding]; other site 930782006037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782006038 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 930782006039 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 930782006040 dimerization interface [polypeptide binding]; other site 930782006041 Histidine kinase; Region: His_kinase; pfam06580 930782006042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782006043 ATP binding site [chemical binding]; other site 930782006044 Mg2+ binding site [ion binding]; other site 930782006045 G-X-G motif; other site 930782006046 Predicted integral membrane protein [Function unknown]; Region: COG5578 930782006047 Uncharacterized conserved protein [Function unknown]; Region: COG3538 930782006048 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 930782006049 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930782006050 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 930782006051 active site 930782006052 metal binding site [ion binding]; metal-binding site 930782006053 homodimer interface [polypeptide binding]; other site 930782006054 catalytic site [active] 930782006055 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930782006056 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 930782006057 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 930782006058 active site 930782006059 catalytic site [active] 930782006060 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 930782006061 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 930782006062 DNA-binding site [nucleotide binding]; DNA binding site 930782006063 RNA-binding motif; other site 930782006064 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 930782006065 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 930782006066 active site 930782006067 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 930782006068 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930782006069 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 930782006070 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 930782006071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 930782006072 active site 930782006073 HIGH motif; other site 930782006074 nucleotide binding site [chemical binding]; other site 930782006075 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 930782006076 active site 930782006077 KMSKS motif; other site 930782006078 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 930782006079 tRNA binding surface [nucleotide binding]; other site 930782006080 anticodon binding site; other site 930782006081 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 930782006082 DivIVA protein; Region: DivIVA; pfam05103 930782006083 DivIVA domain; Region: DivI1A_domain; TIGR03544 930782006084 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 930782006085 HTH domain; Region: HTH_11; pfam08279 930782006086 3H domain; Region: 3H; pfam02829 930782006087 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 930782006088 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 930782006089 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782006090 catalytic residue [active] 930782006091 L-aspartate oxidase; Provisional; Region: PRK08071 930782006092 L-aspartate oxidase; Provisional; Region: PRK06175 930782006093 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 930782006094 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 930782006095 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 930782006096 dimerization interface [polypeptide binding]; other site 930782006097 active site 930782006098 quinolinate synthetase; Provisional; Region: PRK09375 930782006099 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006100 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782006101 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006102 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006103 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006104 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782006105 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006106 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006107 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782006108 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006109 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782006110 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006111 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006112 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006113 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006114 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 930782006115 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006116 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006117 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006118 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 930782006119 Leucine rich repeat; Region: LRR_8; pfam13855 930782006120 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 930782006121 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782006122 Methyltransferase domain; Region: Methyltransf_31; pfam13847 930782006123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782006124 S-adenosylmethionine binding site [chemical binding]; other site 930782006125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782006126 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782006127 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 930782006128 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782006129 RNA binding surface [nucleotide binding]; other site 930782006130 YGGT family; Region: YGGT; pfam02325 930782006131 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 930782006132 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 930782006133 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 930782006134 catalytic residue [active] 930782006135 cell division protein FtsZ; Validated; Region: PRK09330 930782006136 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 930782006137 nucleotide binding site [chemical binding]; other site 930782006138 SulA interaction site; other site 930782006139 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 930782006140 Cell division protein FtsA; Region: FtsA; smart00842 930782006141 Cell division protein FtsA; Region: FtsA; pfam14450 930782006142 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 930782006143 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 930782006144 Cell division protein FtsQ; Region: FtsQ; pfam03799 930782006145 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 930782006146 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 930782006147 active site 930782006148 homodimer interface [polypeptide binding]; other site 930782006149 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 930782006150 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930782006151 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930782006152 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 930782006153 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 930782006154 Mg++ binding site [ion binding]; other site 930782006155 putative catalytic motif [active] 930782006156 putative substrate binding site [chemical binding]; other site 930782006157 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 930782006158 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 930782006159 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 930782006160 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 930782006161 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 930782006162 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 930782006163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930782006164 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 930782006165 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 930782006166 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 930782006167 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 930782006168 MraW methylase family; Region: Methyltransf_5; pfam01795 930782006169 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 930782006170 MraZ protein; Region: MraZ; pfam02381 930782006171 MraZ protein; Region: MraZ; pfam02381 930782006172 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782006173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782006174 putative substrate translocation pore; other site 930782006175 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 930782006176 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 930782006177 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 930782006178 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 930782006179 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 930782006180 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 930782006181 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 930782006182 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 930782006183 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 930782006184 hypothetical protein; Provisional; Region: PRK13670 930782006185 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930782006186 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930782006187 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 930782006188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782006189 Walker A/P-loop; other site 930782006190 ATP binding site [chemical binding]; other site 930782006191 Q-loop/lid; other site 930782006192 ABC transporter signature motif; other site 930782006193 Walker B; other site 930782006194 D-loop; other site 930782006195 H-loop/switch region; other site 930782006196 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 930782006197 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 930782006198 protein binding site [polypeptide binding]; other site 930782006199 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 930782006200 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 930782006201 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 930782006202 active site 930782006203 (T/H)XGH motif; other site 930782006204 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 930782006205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782006206 S-adenosylmethionine binding site [chemical binding]; other site 930782006207 hypothetical protein; Provisional; Region: PRK02886 930782006208 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 930782006209 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 930782006210 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 930782006211 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 930782006212 UbiA prenyltransferase family; Region: UbiA; pfam01040 930782006213 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 930782006214 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 930782006215 Ion transport protein; Region: Ion_trans; pfam00520 930782006216 Ion channel; Region: Ion_trans_2; pfam07885 930782006217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 930782006218 MOSC domain; Region: MOSC; pfam03473 930782006219 3-alpha domain; Region: 3-alpha; pfam03475 930782006220 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 930782006221 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 930782006222 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 930782006223 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 930782006224 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 930782006225 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 930782006226 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 930782006227 active site 930782006228 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 930782006229 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 930782006230 ring oligomerisation interface [polypeptide binding]; other site 930782006231 ATP/Mg binding site [chemical binding]; other site 930782006232 stacking interactions; other site 930782006233 hinge regions; other site 930782006234 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 930782006235 oligomerisation interface [polypeptide binding]; other site 930782006236 mobile loop; other site 930782006237 roof hairpin; other site 930782006238 CAAX protease self-immunity; Region: Abi; pfam02517 930782006239 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 930782006240 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 930782006241 CoA binding domain; Region: CoA_binding; pfam02629 930782006242 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930782006243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782006244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782006245 ABC transporter; Region: ABC_tran_2; pfam12848 930782006246 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782006247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782006248 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930782006249 UGMP family protein; Validated; Region: PRK09604 930782006250 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930782006251 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930782006252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782006253 Coenzyme A binding pocket [chemical binding]; other site 930782006254 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 930782006255 Glycoprotease family; Region: Peptidase_M22; pfam00814 930782006256 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 930782006257 camphor resistance protein CrcB; Provisional; Region: PRK14214 930782006258 camphor resistance protein CrcB; Provisional; Region: PRK14231 930782006259 Uncharacterized conserved protein [Function unknown]; Region: COG4832 930782006260 Phosphotransferase enzyme family; Region: APH; pfam01636 930782006261 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 930782006262 active site 930782006263 substrate binding site [chemical binding]; other site 930782006264 ATP binding site [chemical binding]; other site 930782006265 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006266 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006267 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006268 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782006269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782006270 non-specific DNA binding site [nucleotide binding]; other site 930782006271 salt bridge; other site 930782006272 sequence-specific DNA binding site [nucleotide binding]; other site 930782006273 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 930782006274 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930782006275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782006276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782006277 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930782006278 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930782006279 substrate binding pocket [chemical binding]; other site 930782006280 argininosuccinate synthase; Provisional; Region: PRK13820 930782006281 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 930782006282 ANP binding site [chemical binding]; other site 930782006283 Substrate Binding Site II [chemical binding]; other site 930782006284 Substrate Binding Site I [chemical binding]; other site 930782006285 argininosuccinate lyase; Provisional; Region: PRK00855 930782006286 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 930782006287 active sites [active] 930782006288 tetramer interface [polypeptide binding]; other site 930782006289 BCCT family transporter; Region: BCCT; pfam02028 930782006290 hypothetical protein; Provisional; Region: PRK06357 930782006291 active site 930782006292 intersubunit interface [polypeptide binding]; other site 930782006293 Zn2+ binding site [ion binding]; other site 930782006294 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930782006295 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930782006296 putative substrate binding site [chemical binding]; other site 930782006297 putative ATP binding site [chemical binding]; other site 930782006298 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930782006299 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930782006300 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 930782006301 active site 930782006302 P-loop; other site 930782006303 phosphorylation site [posttranslational modification] 930782006304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782006305 active site 930782006306 phosphorylation site [posttranslational modification] 930782006307 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782006308 PRD domain; Region: PRD; pfam00874 930782006309 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782006310 active site 930782006311 P-loop; other site 930782006312 phosphorylation site [posttranslational modification] 930782006313 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 930782006314 active site 930782006315 phosphorylation site [posttranslational modification] 930782006316 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 930782006317 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782006318 DNA-binding site [nucleotide binding]; DNA binding site 930782006319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782006320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782006321 homodimer interface [polypeptide binding]; other site 930782006322 catalytic residue [active] 930782006323 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 930782006324 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 930782006325 active site 930782006326 multimer interface [polypeptide binding]; other site 930782006327 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 930782006328 conserved cys residue [active] 930782006329 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 930782006330 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 930782006331 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 930782006332 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 930782006333 G1 box; other site 930782006334 GTP/Mg2+ binding site [chemical binding]; other site 930782006335 Switch I region; other site 930782006336 G2 box; other site 930782006337 G3 box; other site 930782006338 Switch II region; other site 930782006339 G4 box; other site 930782006340 G5 box; other site 930782006341 Nucleoside recognition; Region: Gate; pfam07670 930782006342 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 930782006343 Nucleoside recognition; Region: Gate; pfam07670 930782006344 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 930782006345 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 930782006346 putative active site [active] 930782006347 putative metal binding site [ion binding]; other site 930782006348 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782006349 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930782006350 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782006351 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 930782006352 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 930782006353 active site 930782006354 dimer interface [polypeptide binding]; other site 930782006355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930782006356 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 930782006357 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 930782006358 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 930782006359 dimer interface [polypeptide binding]; other site 930782006360 FMN binding site [chemical binding]; other site 930782006361 NADPH bind site [chemical binding]; other site 930782006362 Helix-turn-helix domain; Region: HTH_17; pfam12728 930782006363 putative heme peroxidase; Provisional; Region: PRK12276 930782006364 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782006365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782006366 Walker A/P-loop; other site 930782006367 ATP binding site [chemical binding]; other site 930782006368 Q-loop/lid; other site 930782006369 ABC transporter signature motif; other site 930782006370 Walker B; other site 930782006371 D-loop; other site 930782006372 H-loop/switch region; other site 930782006373 FtsX-like permease family; Region: FtsX; pfam02687 930782006374 FtsX-like permease family; Region: FtsX; pfam02687 930782006375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782006376 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782006377 Coenzyme A binding pocket [chemical binding]; other site 930782006378 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 930782006379 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 930782006380 active site 930782006381 substrate binding site [chemical binding]; other site 930782006382 metal binding site [ion binding]; metal-binding site 930782006383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 930782006384 YbbR-like protein; Region: YbbR; pfam07949 930782006385 YbbR-like protein; Region: YbbR; pfam07949 930782006386 YbbR-like protein; Region: YbbR; pfam07949 930782006387 Uncharacterized conserved protein [Function unknown]; Region: COG1624 930782006388 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 930782006389 maltose phosphorylase; Provisional; Region: PRK13807 930782006390 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 930782006391 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 930782006392 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 930782006393 Predicted integral membrane protein [Function unknown]; Region: COG5521 930782006394 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006396 dimer interface [polypeptide binding]; other site 930782006397 conserved gate region; other site 930782006398 putative PBP binding loops; other site 930782006399 ABC-ATPase subunit interface; other site 930782006400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006401 dimer interface [polypeptide binding]; other site 930782006402 conserved gate region; other site 930782006403 putative PBP binding loops; other site 930782006404 ABC-ATPase subunit interface; other site 930782006405 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 930782006406 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782006407 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 930782006408 homodimer interface [polypeptide binding]; other site 930782006409 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 930782006410 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 930782006411 active site 930782006412 homodimer interface [polypeptide binding]; other site 930782006413 catalytic site [active] 930782006414 CAAX protease self-immunity; Region: Abi; cl00558 930782006415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782006416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782006417 DNA binding site [nucleotide binding] 930782006418 domain linker motif; other site 930782006419 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 930782006420 ligand binding site [chemical binding]; other site 930782006421 dimerization interface [polypeptide binding]; other site 930782006422 Amino acid permease; Region: AA_permease_2; pfam13520 930782006423 K+ potassium transporter; Region: K_trans; cl15781 930782006424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782006425 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782006426 ligand binding site [chemical binding]; other site 930782006427 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782006428 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782006429 ligand binding site [chemical binding]; other site 930782006430 flexible hinge region; other site 930782006431 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782006432 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930782006433 intersubunit interface [polypeptide binding]; other site 930782006434 active site 930782006435 zinc binding site [ion binding]; other site 930782006436 Na+ binding site [ion binding]; other site 930782006437 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930782006438 intersubunit interface [polypeptide binding]; other site 930782006439 active site 930782006440 zinc binding site [ion binding]; other site 930782006441 Na+ binding site [ion binding]; other site 930782006442 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930782006443 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930782006444 active site 930782006445 P-loop; other site 930782006446 phosphorylation site [posttranslational modification] 930782006447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782006448 active site 930782006449 phosphorylation site [posttranslational modification] 930782006450 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782006451 HTH domain; Region: HTH_11; pfam08279 930782006452 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782006453 PRD domain; Region: PRD; pfam00874 930782006454 PRD domain; Region: PRD; pfam00874 930782006455 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782006456 active site 930782006457 P-loop; other site 930782006458 phosphorylation site [posttranslational modification] 930782006459 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 930782006460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782006461 Walker A/P-loop; other site 930782006462 ATP binding site [chemical binding]; other site 930782006463 Q-loop/lid; other site 930782006464 ABC transporter signature motif; other site 930782006465 Walker B; other site 930782006466 D-loop; other site 930782006467 H-loop/switch region; other site 930782006468 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 930782006469 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 930782006470 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 930782006471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782006472 Coenzyme A binding pocket [chemical binding]; other site 930782006473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 930782006474 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 930782006475 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 930782006476 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782006477 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782006478 DNA-binding site [nucleotide binding]; DNA binding site 930782006479 UTRA domain; Region: UTRA; pfam07702 930782006480 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 930782006481 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 930782006482 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782006483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782006484 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 930782006485 putative dimerization interface [polypeptide binding]; other site 930782006486 Predicted membrane protein [Function unknown]; Region: COG2855 930782006487 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 930782006488 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 930782006489 putative metal binding site [ion binding]; other site 930782006490 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 930782006491 homodimer interface [polypeptide binding]; other site 930782006492 chemical substrate binding site [chemical binding]; other site 930782006493 oligomer interface [polypeptide binding]; other site 930782006494 metal binding site [ion binding]; metal-binding site 930782006495 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782006496 catalytic residues [active] 930782006497 flavodoxin; Provisional; Region: PRK09271 930782006498 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 930782006499 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 930782006500 dimer interface [polypeptide binding]; other site 930782006501 putative radical transfer pathway; other site 930782006502 diiron center [ion binding]; other site 930782006503 tyrosyl radical; other site 930782006504 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 930782006505 Class I ribonucleotide reductase; Region: RNR_I; cd01679 930782006506 active site 930782006507 dimer interface [polypeptide binding]; other site 930782006508 catalytic residues [active] 930782006509 effector binding site; other site 930782006510 R2 peptide binding site; other site 930782006511 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 930782006512 SCP-2 sterol transfer family; Region: SCP2; cl01225 930782006513 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 930782006514 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 930782006515 CsbD-like; Region: CsbD; cl17424 930782006516 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782006517 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782006518 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930782006519 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930782006520 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 930782006521 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 930782006522 conserved cys residue [active] 930782006523 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930782006524 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782006525 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782006526 Cupin; Region: Cupin_1; pfam00190 930782006527 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782006528 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782006529 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782006530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782006531 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782006532 ligand binding site [chemical binding]; other site 930782006533 flexible hinge region; other site 930782006534 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 930782006535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 930782006536 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782006537 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 930782006538 dimer interface [polypeptide binding]; other site 930782006539 active site 930782006540 metal binding site [ion binding]; metal-binding site 930782006541 glutathione binding site [chemical binding]; other site 930782006542 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 930782006543 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 930782006544 FMN binding site [chemical binding]; other site 930782006545 substrate binding site [chemical binding]; other site 930782006546 putative catalytic residue [active] 930782006547 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 930782006548 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 930782006549 Coenzyme A transferase; Region: CoA_trans; smart00882 930782006550 Coenzyme A transferase; Region: CoA_trans; cl17247 930782006551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782006552 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 930782006553 Walker A motif; other site 930782006554 ATP binding site [chemical binding]; other site 930782006555 Walker B motif; other site 930782006556 arginine finger; other site 930782006557 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 930782006558 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 930782006559 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 930782006560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 930782006561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 930782006562 metal binding site [ion binding]; metal-binding site 930782006563 active site 930782006564 I-site; other site 930782006565 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 930782006566 classical (c) SDRs; Region: SDR_c; cd05233 930782006567 NAD(P) binding site [chemical binding]; other site 930782006568 active site 930782006569 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 930782006570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782006571 Tic20-like protein; Region: Tic20; pfam09685 930782006572 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930782006573 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006574 Collagen binding domain; Region: Collagen_bind; pfam05737 930782006575 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006576 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006577 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006578 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006579 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782006580 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930782006581 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006582 Collagen binding domain; Region: Collagen_bind; pfam05737 930782006583 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006584 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006585 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006586 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006587 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006588 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006589 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782006590 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782006591 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782006592 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782006593 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782006594 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 930782006595 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 930782006596 active site 930782006597 catalytic site [active] 930782006598 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930782006599 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930782006600 Walker A/P-loop; other site 930782006601 ATP binding site [chemical binding]; other site 930782006602 Q-loop/lid; other site 930782006603 ABC transporter signature motif; other site 930782006604 Walker B; other site 930782006605 D-loop; other site 930782006606 H-loop/switch region; other site 930782006607 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 930782006608 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782006609 ABC-ATPase subunit interface; other site 930782006610 dimer interface [polypeptide binding]; other site 930782006611 putative PBP binding regions; other site 930782006612 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 930782006613 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930782006614 intersubunit interface [polypeptide binding]; other site 930782006615 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930782006616 heme-binding site [chemical binding]; other site 930782006617 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 930782006618 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930782006619 heme-binding site [chemical binding]; other site 930782006620 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930782006621 heme-binding site [chemical binding]; other site 930782006622 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 930782006623 heme uptake protein IsdC; Region: IsdC; TIGR03656 930782006624 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 930782006625 heme-binding site [chemical binding]; other site 930782006626 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 930782006627 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 930782006628 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 930782006629 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 930782006630 active site 930782006631 Zn binding site [ion binding]; other site 930782006632 Competence protein CoiA-like family; Region: CoiA; cl11541 930782006633 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 930782006634 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 930782006635 ArsC family; Region: ArsC; pfam03960 930782006636 putative catalytic residues [active] 930782006637 thiol/disulfide switch; other site 930782006638 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 930782006639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930782006640 Walker A/P-loop; other site 930782006641 ATP binding site [chemical binding]; other site 930782006642 Q-loop/lid; other site 930782006643 ABC transporter signature motif; other site 930782006644 Walker B; other site 930782006645 D-loop; other site 930782006646 H-loop/switch region; other site 930782006647 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930782006648 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 930782006649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 930782006650 Walker A/P-loop; other site 930782006651 ATP binding site [chemical binding]; other site 930782006652 Q-loop/lid; other site 930782006653 ABC transporter signature motif; other site 930782006654 Walker B; other site 930782006655 D-loop; other site 930782006656 H-loop/switch region; other site 930782006657 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 930782006658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930782006659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006660 dimer interface [polypeptide binding]; other site 930782006661 conserved gate region; other site 930782006662 putative PBP binding loops; other site 930782006663 ABC-ATPase subunit interface; other site 930782006664 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930782006665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006666 dimer interface [polypeptide binding]; other site 930782006667 conserved gate region; other site 930782006668 putative PBP binding loops; other site 930782006669 ABC-ATPase subunit interface; other site 930782006670 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930782006671 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930782006672 peptide binding site [polypeptide binding]; other site 930782006673 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 930782006674 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 930782006675 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 930782006676 active site 930782006677 HIGH motif; other site 930782006678 dimer interface [polypeptide binding]; other site 930782006679 KMSKS motif; other site 930782006680 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 930782006681 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782006682 MarR family; Region: MarR; pfam01047 930782006683 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 930782006684 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 930782006685 dimer interface [polypeptide binding]; other site 930782006686 active site 930782006687 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 930782006688 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 930782006689 dimer interface [polypeptide binding]; other site 930782006690 active site 930782006691 CoA binding pocket [chemical binding]; other site 930782006692 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782006693 SH3-like domain; Region: SH3_8; pfam13457 930782006694 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 930782006695 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782006696 catalytic core [active] 930782006697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 930782006698 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 930782006699 Clp amino terminal domain; Region: Clp_N; pfam02861 930782006700 Clp amino terminal domain; Region: Clp_N; pfam02861 930782006701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782006702 Walker A motif; other site 930782006703 ATP binding site [chemical binding]; other site 930782006704 Walker B motif; other site 930782006705 arginine finger; other site 930782006706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782006707 Walker A motif; other site 930782006708 ATP binding site [chemical binding]; other site 930782006709 Walker B motif; other site 930782006710 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 930782006711 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 930782006712 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 930782006713 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782006714 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782006715 active site 930782006716 motif I; other site 930782006717 motif II; other site 930782006718 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930782006719 Predicted acetyltransferase [General function prediction only]; Region: COG3393 930782006720 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930782006721 ferrochelatase; Provisional; Region: PRK12435 930782006722 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 930782006723 C-terminal domain interface [polypeptide binding]; other site 930782006724 active site 930782006725 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 930782006726 active site 930782006727 N-terminal domain interface [polypeptide binding]; other site 930782006728 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 930782006729 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 930782006730 substrate binding site [chemical binding]; other site 930782006731 active site 930782006732 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 930782006733 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 930782006734 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930782006735 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782006736 Walker A/P-loop; other site 930782006737 ATP binding site [chemical binding]; other site 930782006738 Q-loop/lid; other site 930782006739 ABC transporter signature motif; other site 930782006740 Walker B; other site 930782006741 D-loop; other site 930782006742 H-loop/switch region; other site 930782006743 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 930782006744 HIT family signature motif; other site 930782006745 catalytic residue [active] 930782006746 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 930782006747 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 930782006748 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 930782006749 SurA N-terminal domain; Region: SurA_N_3; cl07813 930782006750 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 930782006751 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 930782006752 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 930782006753 generic binding surface II; other site 930782006754 generic binding surface I; other site 930782006755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782006756 Zn2+ binding site [ion binding]; other site 930782006757 Mg2+ binding site [ion binding]; other site 930782006758 Uncharacterized conserved protein [Function unknown]; Region: COG4717 930782006759 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 930782006760 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 930782006761 active site 930782006762 metal binding site [ion binding]; metal-binding site 930782006763 DNA binding site [nucleotide binding] 930782006764 hypothetical protein; Provisional; Region: PRK13676 930782006765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 930782006766 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 930782006767 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930782006768 Int/Topo IB signature motif; other site 930782006769 Helix-turn-helix domain; Region: HTH_16; pfam12645 930782006770 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 930782006771 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 930782006772 DNA binding residues [nucleotide binding] 930782006773 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 930782006774 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 930782006775 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 930782006776 P loop; other site 930782006777 Nucleotide binding site [chemical binding]; other site 930782006778 DTAP/Switch II; other site 930782006779 Switch I; other site 930782006780 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 930782006781 P loop; other site 930782006782 Nucleotide binding site [chemical binding]; other site 930782006783 DTAP/Switch II; other site 930782006784 Switch I; other site 930782006785 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782006786 dimerization interface [polypeptide binding]; other site 930782006787 putative DNA binding site [nucleotide binding]; other site 930782006788 putative Zn2+ binding site [ion binding]; other site 930782006789 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 930782006790 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782006791 dimerization interface [polypeptide binding]; other site 930782006792 putative DNA binding site [nucleotide binding]; other site 930782006793 putative Zn2+ binding site [ion binding]; other site 930782006794 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 930782006795 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 930782006796 P loop; other site 930782006797 Nucleotide binding site [chemical binding]; other site 930782006798 DTAP/Switch II; other site 930782006799 Switch I; other site 930782006800 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 930782006801 DTAP/Switch II; other site 930782006802 Switch I; other site 930782006803 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 930782006804 arsenical-resistance protein; Region: acr3; TIGR00832 930782006805 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 930782006806 arsenical-resistance protein; Region: acr3; TIGR00832 930782006807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782006808 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 930782006809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782006810 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 930782006811 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 930782006812 active site residue [active] 930782006813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782006814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782006815 Walker A/P-loop; other site 930782006816 ATP binding site [chemical binding]; other site 930782006817 Q-loop/lid; other site 930782006818 ABC transporter signature motif; other site 930782006819 Walker B; other site 930782006820 D-loop; other site 930782006821 H-loop/switch region; other site 930782006822 inner membrane transport permease; Provisional; Region: PRK15066 930782006823 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 930782006824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782006825 putative DNA binding site [nucleotide binding]; other site 930782006826 dimerization interface [polypeptide binding]; other site 930782006827 putative Zn2+ binding site [ion binding]; other site 930782006828 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 930782006829 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 930782006830 metal-binding site [ion binding] 930782006831 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782006832 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930782006833 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 930782006834 N-acetyl-D-glucosamine binding site [chemical binding]; other site 930782006835 catalytic residue [active] 930782006836 TIGR02594 family protein; Region: TIGR02594 930782006837 AAA-like domain; Region: AAA_10; pfam12846 930782006838 TcpE family; Region: TcpE; pfam12648 930782006839 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 930782006840 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 930782006841 Antirestriction protein (ArdA); Region: ArdA; cl01953 930782006842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782006843 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782006844 non-specific DNA binding site [nucleotide binding]; other site 930782006845 salt bridge; other site 930782006846 sequence-specific DNA binding site [nucleotide binding]; other site 930782006847 Replication initiation factor; Region: Rep_trans; pfam02486 930782006848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930782006849 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 930782006850 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 930782006851 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006852 Cna protein B-type domain; Region: Cna_B; pfam05738 930782006853 Domain of unknown function (DUF4297); Region: DUF4297; pfam14130 930782006854 TIGR03545 family protein; Region: TIGR03545 930782006855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 930782006856 fumarate hydratase; Reviewed; Region: fumC; PRK00485 930782006857 Class II fumarases; Region: Fumarase_classII; cd01362 930782006858 active site 930782006859 tetramer interface [polypeptide binding]; other site 930782006860 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930782006861 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 930782006862 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782006863 Walker A/P-loop; other site 930782006864 ATP binding site [chemical binding]; other site 930782006865 Q-loop/lid; other site 930782006866 ABC transporter signature motif; other site 930782006867 Walker B; other site 930782006868 D-loop; other site 930782006869 H-loop/switch region; other site 930782006870 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930782006871 Transglycosylase; Region: Transgly; pfam00912 930782006872 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 930782006873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 930782006874 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930782006875 Low molecular weight phosphatase family; Region: LMWPc; cl00105 930782006876 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930782006877 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930782006878 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930782006879 Domain of unknown function DUF21; Region: DUF21; pfam01595 930782006880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930782006881 Transporter associated domain; Region: CorC_HlyC; smart01091 930782006882 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782006883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782006884 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 930782006885 putative dimerization interface [polypeptide binding]; other site 930782006886 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 930782006887 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 930782006888 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 930782006889 active site 930782006890 FMN binding site [chemical binding]; other site 930782006891 substrate binding site [chemical binding]; other site 930782006892 putative catalytic residue [active] 930782006893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782006894 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782006895 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 930782006896 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 930782006897 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 930782006898 shikimate binding site; other site 930782006899 NAD(P) binding site [chemical binding]; other site 930782006900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782006901 putative substrate translocation pore; other site 930782006902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782006903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782006904 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782006905 putative substrate translocation pore; other site 930782006906 Predicted transcriptional regulators [Transcription]; Region: COG1725 930782006907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782006908 DNA-binding site [nucleotide binding]; DNA binding site 930782006909 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930782006910 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930782006911 DNA binding site [nucleotide binding] 930782006912 active site 930782006913 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930782006914 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930782006915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782006916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782006917 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 930782006918 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 930782006919 active site 930782006920 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 930782006921 putative dimer interface [polypeptide binding]; other site 930782006922 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782006923 ligand binding site [chemical binding]; other site 930782006924 Zn binding site [ion binding]; other site 930782006925 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930782006926 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 930782006927 active site 930782006928 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782006929 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782006930 active site 930782006931 catalytic tetrad [active] 930782006932 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 930782006933 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 930782006934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930782006935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930782006936 substrate binding pocket [chemical binding]; other site 930782006937 membrane-bound complex binding site; other site 930782006938 hinge residues; other site 930782006939 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930782006940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782006941 dimer interface [polypeptide binding]; other site 930782006942 conserved gate region; other site 930782006943 putative PBP binding loops; other site 930782006944 ABC-ATPase subunit interface; other site 930782006945 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930782006946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930782006947 Walker A/P-loop; other site 930782006948 ATP binding site [chemical binding]; other site 930782006949 Q-loop/lid; other site 930782006950 ABC transporter signature motif; other site 930782006951 Walker B; other site 930782006952 D-loop; other site 930782006953 H-loop/switch region; other site 930782006954 aspartate aminotransferase; Provisional; Region: PRK06348 930782006955 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782006956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782006957 homodimer interface [polypeptide binding]; other site 930782006958 catalytic residue [active] 930782006959 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 930782006960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782006961 motif II; other site 930782006962 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 930782006963 intracellular protease, PfpI family; Region: PfpI; TIGR01382 930782006964 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 930782006965 proposed catalytic triad [active] 930782006966 conserved cys residue [active] 930782006967 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782006968 methionine cluster; other site 930782006969 active site 930782006970 phosphorylation site [posttranslational modification] 930782006971 metal binding site [ion binding]; metal-binding site 930782006972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782006973 Coenzyme A binding pocket [chemical binding]; other site 930782006974 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782006975 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 930782006976 esterase; Provisional; Region: PRK10566 930782006977 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930782006978 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782006979 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930782006980 motif II; other site 930782006981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782006982 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930782006983 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782006984 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782006985 hypothetical protein; Provisional; Region: PRK13673 930782006986 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 930782006987 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 930782006988 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 930782006989 Part of AAA domain; Region: AAA_19; pfam13245 930782006990 Family description; Region: UvrD_C_2; pfam13538 930782006991 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930782006992 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 930782006993 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 930782006994 IDEAL domain; Region: IDEAL; pfam08858 930782006995 ComK protein; Region: ComK; cl11560 930782006996 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782006997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782006998 non-specific DNA binding site [nucleotide binding]; other site 930782006999 salt bridge; other site 930782007000 sequence-specific DNA binding site [nucleotide binding]; other site 930782007001 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 930782007002 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782007003 active site 930782007004 phosphorylation site [posttranslational modification] 930782007005 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 930782007006 active site 930782007007 P-loop; other site 930782007008 phosphorylation site [posttranslational modification] 930782007009 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 930782007010 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 930782007011 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 930782007012 putative substrate binding site [chemical binding]; other site 930782007013 putative ATP binding site [chemical binding]; other site 930782007014 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782007015 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930782007016 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782007017 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 930782007018 trimer interface [polypeptide binding]; other site 930782007019 active site 930782007020 G bulge; other site 930782007021 Uncharacterized conserved protein [Function unknown]; Region: COG1683 930782007022 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 930782007023 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 930782007024 non-specific DNA interactions [nucleotide binding]; other site 930782007025 DNA binding site [nucleotide binding] 930782007026 sequence specific DNA binding site [nucleotide binding]; other site 930782007027 putative cAMP binding site [chemical binding]; other site 930782007028 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 930782007029 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 930782007030 substrate binding site [chemical binding]; other site 930782007031 ATP binding site [chemical binding]; other site 930782007032 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 930782007033 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782007034 RNA binding surface [nucleotide binding]; other site 930782007035 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 930782007036 active site 930782007037 uracil binding [chemical binding]; other site 930782007038 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 930782007039 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 930782007040 active site 930782007041 non-prolyl cis peptide bond; other site 930782007042 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 930782007043 catalytic residues [active] 930782007044 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 930782007045 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 930782007046 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 930782007047 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 930782007048 Walker A/P-loop; other site 930782007049 ATP binding site [chemical binding]; other site 930782007050 Q-loop/lid; other site 930782007051 ABC transporter signature motif; other site 930782007052 Walker B; other site 930782007053 D-loop; other site 930782007054 H-loop/switch region; other site 930782007055 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930782007056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782007057 dimer interface [polypeptide binding]; other site 930782007058 conserved gate region; other site 930782007059 putative PBP binding loops; other site 930782007060 ABC-ATPase subunit interface; other site 930782007061 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 930782007062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782007063 dimer interface [polypeptide binding]; other site 930782007064 conserved gate region; other site 930782007065 putative PBP binding loops; other site 930782007066 ABC-ATPase subunit interface; other site 930782007067 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 930782007068 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 930782007069 substrate binding pocket [chemical binding]; other site 930782007070 membrane-bound complex binding site; other site 930782007071 hinge residues; other site 930782007072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782007073 Coenzyme A binding pocket [chemical binding]; other site 930782007074 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 930782007075 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 930782007076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 930782007077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 930782007078 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 930782007079 dimerization interface [polypeptide binding]; other site 930782007080 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 930782007081 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 930782007082 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 930782007083 active site 930782007084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782007085 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782007086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782007087 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 930782007088 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930782007089 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930782007090 active site 930782007091 trimer interface [polypeptide binding]; other site 930782007092 allosteric site; other site 930782007093 active site lid [active] 930782007094 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930782007095 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782007096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 930782007097 Predicted membrane protein [Function unknown]; Region: COG1511 930782007098 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930782007099 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 930782007100 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 930782007101 Predicted transcriptional regulator [Transcription]; Region: COG1959 930782007102 Transcriptional regulator; Region: Rrf2; pfam02082 930782007103 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 930782007104 L-tyrosine decarboxylase; Provisional; Region: PRK13520 930782007105 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 930782007106 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782007107 catalytic residue [active] 930782007108 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 930782007109 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782007110 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 930782007111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 930782007112 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 930782007113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 930782007114 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 930782007115 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 930782007116 active site 930782007117 dimer interface [polypeptide binding]; other site 930782007118 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 930782007119 dimer interface [polypeptide binding]; other site 930782007120 active site 930782007121 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 930782007122 nudix motif; other site 930782007123 general stress protein 13; Validated; Region: PRK08059 930782007124 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930782007125 RNA binding site [nucleotide binding]; other site 930782007126 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 930782007127 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 930782007128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782007129 homodimer interface [polypeptide binding]; other site 930782007130 catalytic residue [active] 930782007131 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 930782007132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782007133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782007134 Walker A/P-loop; other site 930782007135 ATP binding site [chemical binding]; other site 930782007136 Q-loop/lid; other site 930782007137 ABC transporter signature motif; other site 930782007138 Walker B; other site 930782007139 D-loop; other site 930782007140 H-loop/switch region; other site 930782007141 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782007142 active site 930782007143 P-loop; other site 930782007144 phosphorylation site [posttranslational modification] 930782007145 aspartate kinase; Reviewed; Region: PRK09034 930782007146 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 930782007147 putative catalytic residues [active] 930782007148 putative nucleotide binding site [chemical binding]; other site 930782007149 putative aspartate binding site [chemical binding]; other site 930782007150 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 930782007151 allosteric regulatory residue; other site 930782007152 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 930782007153 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 930782007154 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 930782007155 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930782007156 glutamine binding [chemical binding]; other site 930782007157 catalytic triad [active] 930782007158 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 930782007159 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 930782007160 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 930782007161 hypothetical protein; Provisional; Region: PRK07206 930782007162 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 930782007163 Chorismate mutase type II; Region: CM_2; smart00830 930782007164 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 930782007165 Peptidase family U32; Region: Peptidase_U32; cl03113 930782007166 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 930782007167 active site 930782007168 drug efflux system protein MdtG; Provisional; Region: PRK09874 930782007169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782007170 putative substrate translocation pore; other site 930782007171 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 930782007172 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930782007173 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 930782007174 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 930782007175 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 930782007176 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 930782007177 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 930782007178 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 930782007179 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 930782007180 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 930782007181 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 930782007182 CoenzymeA binding site [chemical binding]; other site 930782007183 subunit interaction site [polypeptide binding]; other site 930782007184 PHB binding site; other site 930782007185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 930782007186 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 930782007187 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 930782007188 Cl- selectivity filter; other site 930782007189 Cl- binding residues [ion binding]; other site 930782007190 pore gating glutamate residue; other site 930782007191 dimer interface [polypeptide binding]; other site 930782007192 Transposase domain (DUF772); Region: DUF772; pfam05598 930782007193 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 930782007194 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 930782007195 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 930782007196 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 930782007198 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930782007199 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782007200 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 930782007201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782007202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782007203 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 930782007204 NADH(P)-binding; Region: NAD_binding_10; pfam13460 930782007205 NAD(P) binding site [chemical binding]; other site 930782007206 putative active site [active] 930782007207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 930782007208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 930782007209 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 930782007210 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 930782007211 tetramer interfaces [polypeptide binding]; other site 930782007212 binuclear metal-binding site [ion binding]; other site 930782007213 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930782007214 Domain of unknown function DUF21; Region: DUF21; pfam01595 930782007215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930782007216 Transporter associated domain; Region: CorC_HlyC; smart01091 930782007217 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782007218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782007219 Coenzyme A binding pocket [chemical binding]; other site 930782007220 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 930782007221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782007222 active site 930782007223 motif I; other site 930782007224 motif II; other site 930782007225 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782007226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 930782007227 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930782007228 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 930782007229 active site 930782007230 metal binding site [ion binding]; metal-binding site 930782007231 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930782007232 Predicted permeases [General function prediction only]; Region: COG0730 930782007233 Predicted membrane protein [Function unknown]; Region: COG4272 930782007234 Uncharacterized conserved protein [Function unknown]; Region: COG1801 930782007235 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 930782007236 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 930782007237 FeS assembly protein SufB; Region: sufB; TIGR01980 930782007238 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 930782007239 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 930782007240 trimerization site [polypeptide binding]; other site 930782007241 active site 930782007242 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 930782007243 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 930782007244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782007245 catalytic residue [active] 930782007246 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 930782007247 FeS assembly protein SufD; Region: sufD; TIGR01981 930782007248 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 930782007249 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 930782007250 Walker A/P-loop; other site 930782007251 ATP binding site [chemical binding]; other site 930782007252 Q-loop/lid; other site 930782007253 ABC transporter signature motif; other site 930782007254 Walker B; other site 930782007255 D-loop; other site 930782007256 H-loop/switch region; other site 930782007257 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 930782007258 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 930782007259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782007260 ABC-ATPase subunit interface; other site 930782007261 putative PBP binding loops; other site 930782007262 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 930782007263 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 930782007264 Walker A/P-loop; other site 930782007265 ATP binding site [chemical binding]; other site 930782007266 Q-loop/lid; other site 930782007267 ABC transporter signature motif; other site 930782007268 Walker B; other site 930782007269 D-loop; other site 930782007270 H-loop/switch region; other site 930782007271 NIL domain; Region: NIL; pfam09383 930782007272 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782007273 dimer interface [polypeptide binding]; other site 930782007274 phosphorylation site [posttranslational modification] 930782007275 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782007276 ATP binding site [chemical binding]; other site 930782007277 Mg2+ binding site [ion binding]; other site 930782007278 G-X-G motif; other site 930782007279 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782007280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782007281 active site 930782007282 phosphorylation site [posttranslational modification] 930782007283 intermolecular recognition site; other site 930782007284 dimerization interface [polypeptide binding]; other site 930782007285 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782007286 DNA binding site [nucleotide binding] 930782007287 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930782007288 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 930782007289 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782007290 catalytic residues [active] 930782007291 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 930782007292 lipoyl attachment site [posttranslational modification]; other site 930782007293 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 930782007294 ArsC family; Region: ArsC; pfam03960 930782007295 putative ArsC-like catalytic residues; other site 930782007296 putative TRX-like catalytic residues [active] 930782007297 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930782007298 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 930782007299 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 930782007300 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 930782007301 Walker A/P-loop; other site 930782007302 ATP binding site [chemical binding]; other site 930782007303 Q-loop/lid; other site 930782007304 ABC transporter signature motif; other site 930782007305 Walker B; other site 930782007306 D-loop; other site 930782007307 H-loop/switch region; other site 930782007308 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 930782007309 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782007310 ABC-ATPase subunit interface; other site 930782007311 dimer interface [polypeptide binding]; other site 930782007312 putative PBP binding regions; other site 930782007313 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 930782007314 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 930782007315 intersubunit interface [polypeptide binding]; other site 930782007316 Predicted esterase [General function prediction only]; Region: COG0627 930782007317 S-formylglutathione hydrolase; Region: PLN02442 930782007318 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 930782007319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782007320 catalytic residue [active] 930782007321 SdpI/YhfL protein family; Region: SdpI; pfam13630 930782007322 CAT RNA binding domain; Region: CAT_RBD; smart01061 930782007323 transcriptional antiterminator BglG; Provisional; Region: PRK09772 930782007324 PRD domain; Region: PRD; pfam00874 930782007325 PRD domain; Region: PRD; pfam00874 930782007326 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 930782007327 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 930782007328 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 930782007329 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 930782007330 Predicted transcriptional regulator [Transcription]; Region: COG2378 930782007331 HTH domain; Region: HTH_11; pfam08279 930782007332 WYL domain; Region: WYL; pfam13280 930782007333 Uncharacterized conserved protein [Function unknown]; Region: COG1434 930782007334 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 930782007335 putative active site [active] 930782007336 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782007337 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930782007338 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 930782007339 active site 930782007340 catalytic site [active] 930782007341 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930782007342 putative metal binding site [ion binding]; other site 930782007343 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930782007344 putative metal binding site [ion binding]; other site 930782007345 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782007346 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930782007347 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930782007348 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 930782007349 active site 930782007350 catalytic site [active] 930782007351 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 930782007352 putative metal binding site [ion binding]; other site 930782007353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782007354 non-specific DNA binding site [nucleotide binding]; other site 930782007355 salt bridge; other site 930782007356 sequence-specific DNA binding site [nucleotide binding]; other site 930782007357 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 930782007358 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 930782007359 SmpB-tmRNA interface; other site 930782007360 ribonuclease R; Region: RNase_R; TIGR02063 930782007361 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 930782007362 RNB domain; Region: RNB; pfam00773 930782007363 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 930782007364 RNA binding site [nucleotide binding]; other site 930782007365 Esterase/lipase [General function prediction only]; Region: COG1647 930782007366 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782007367 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 930782007368 Preprotein translocase SecG subunit; Region: SecG; cl09123 930782007369 Esterase/lipase [General function prediction only]; Region: COG1647 930782007370 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 930782007371 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 930782007372 PGAP1-like protein; Region: PGAP1; pfam07819 930782007373 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 930782007374 enolase; Provisional; Region: eno; PRK00077 930782007375 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 930782007376 dimer interface [polypeptide binding]; other site 930782007377 metal binding site [ion binding]; metal-binding site 930782007378 substrate binding pocket [chemical binding]; other site 930782007379 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 930782007380 phosphoglyceromutase; Provisional; Region: PRK05434 930782007381 triosephosphate isomerase; Provisional; Region: PRK14567 930782007382 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 930782007383 substrate binding site [chemical binding]; other site 930782007384 dimer interface [polypeptide binding]; other site 930782007385 catalytic triad [active] 930782007386 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 930782007387 Phosphoglycerate kinase; Region: PGK; pfam00162 930782007388 substrate binding site [chemical binding]; other site 930782007389 hinge regions; other site 930782007390 ADP binding site [chemical binding]; other site 930782007391 catalytic site [active] 930782007392 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 930782007393 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 930782007394 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 930782007395 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 930782007396 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 930782007397 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 930782007398 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 930782007399 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 930782007400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782007401 DNA binding site [nucleotide binding] 930782007402 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 930782007403 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 930782007404 active site 930782007405 dimer interface [polypeptide binding]; other site 930782007406 MMPL family; Region: MMPL; pfam03176 930782007407 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 930782007408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782007409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782007410 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 930782007411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 930782007412 Chitin binding domain; Region: Chitin_bind_3; pfam03067 930782007413 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930782007414 Interdomain contacts; other site 930782007415 Cytokine receptor motif; other site 930782007416 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 930782007417 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930782007418 Interdomain contacts; other site 930782007419 Cytokine receptor motif; other site 930782007420 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930782007421 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930782007422 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930782007423 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930782007424 Clp protease; Region: CLP_protease; pfam00574 930782007425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 930782007426 oligomer interface [polypeptide binding]; other site 930782007427 active site residues [active] 930782007428 amino acid transporter; Region: 2A0306; TIGR00909 930782007429 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 930782007430 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 930782007431 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782007432 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782007433 Substrate binding site [chemical binding]; other site 930782007434 Leucine rich repeat; Region: LRR_8; pfam13855 930782007435 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782007436 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 930782007437 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 930782007438 active site 930782007439 FMN binding site [chemical binding]; other site 930782007440 substrate binding site [chemical binding]; other site 930782007441 homotetramer interface [polypeptide binding]; other site 930782007442 catalytic residue [active] 930782007443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 930782007444 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 930782007445 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 930782007446 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 930782007447 phosphate binding site [ion binding]; other site 930782007448 putative substrate binding pocket [chemical binding]; other site 930782007449 dimer interface [polypeptide binding]; other site 930782007450 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 930782007451 AAA domain; Region: AAA_18; pfam13238 930782007452 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 930782007453 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 930782007454 active site 930782007455 substrate binding site [chemical binding]; other site 930782007456 metal binding site [ion binding]; metal-binding site 930782007457 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 930782007458 active site 930782007459 catalytic residues [active] 930782007460 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 930782007461 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 930782007462 NAD binding site [chemical binding]; other site 930782007463 homodimer interface [polypeptide binding]; other site 930782007464 active site 930782007465 substrate binding site [chemical binding]; other site 930782007466 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 930782007467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 930782007468 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782007469 TPR repeat; Region: TPR_11; pfam13414 930782007470 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782007471 binding surface 930782007472 TPR motif; other site 930782007473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 930782007474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 930782007475 binding surface 930782007476 TPR motif; other site 930782007477 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 930782007478 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 930782007479 putative trimer interface [polypeptide binding]; other site 930782007480 putative CoA binding site [chemical binding]; other site 930782007481 pyrophosphatase PpaX; Provisional; Region: PRK13288 930782007482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782007483 motif II; other site 930782007484 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 930782007485 HPr kinase/phosphorylase; Provisional; Region: PRK05428 930782007486 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 930782007487 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 930782007488 Hpr binding site; other site 930782007489 active site 930782007490 homohexamer subunit interaction site [polypeptide binding]; other site 930782007491 Predicted membrane protein [Function unknown]; Region: COG1950 930782007492 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 930782007493 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 930782007494 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930782007495 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930782007496 Uncharacterized conserved protein [Function unknown]; Region: COG3595 930782007497 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 930782007498 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 930782007499 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930782007500 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 930782007501 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 930782007502 excinuclease ABC subunit B; Provisional; Region: PRK05298 930782007503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782007504 ATP binding site [chemical binding]; other site 930782007505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782007506 nucleotide binding region [chemical binding]; other site 930782007507 ATP-binding site [chemical binding]; other site 930782007508 Ultra-violet resistance protein B; Region: UvrB; pfam12344 930782007509 UvrB/uvrC motif; Region: UVR; pfam02151 930782007510 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 930782007511 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 930782007512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782007513 dimerization interface [polypeptide binding]; other site 930782007514 putative DNA binding site [nucleotide binding]; other site 930782007515 putative Zn2+ binding site [ion binding]; other site 930782007516 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 930782007517 PhoU domain; Region: PhoU; pfam01895 930782007518 PhoU domain; Region: PhoU; pfam01895 930782007519 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 930782007520 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930782007521 Walker A/P-loop; other site 930782007522 ATP binding site [chemical binding]; other site 930782007523 Q-loop/lid; other site 930782007524 ABC transporter signature motif; other site 930782007525 Walker B; other site 930782007526 D-loop; other site 930782007527 H-loop/switch region; other site 930782007528 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 930782007529 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 930782007530 Walker A/P-loop; other site 930782007531 ATP binding site [chemical binding]; other site 930782007532 Q-loop/lid; other site 930782007533 ABC transporter signature motif; other site 930782007534 Walker B; other site 930782007535 D-loop; other site 930782007536 H-loop/switch region; other site 930782007537 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 930782007538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782007539 dimer interface [polypeptide binding]; other site 930782007540 conserved gate region; other site 930782007541 putative PBP binding loops; other site 930782007542 ABC-ATPase subunit interface; other site 930782007543 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 930782007544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782007545 dimer interface [polypeptide binding]; other site 930782007546 conserved gate region; other site 930782007547 putative PBP binding loops; other site 930782007548 ABC-ATPase subunit interface; other site 930782007549 PBP superfamily domain; Region: PBP_like_2; cl17296 930782007550 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 930782007551 HAMP domain; Region: HAMP; pfam00672 930782007552 dimerization interface [polypeptide binding]; other site 930782007553 PAS domain; Region: PAS; smart00091 930782007554 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 930782007555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782007556 dimer interface [polypeptide binding]; other site 930782007557 phosphorylation site [posttranslational modification] 930782007558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782007559 ATP binding site [chemical binding]; other site 930782007560 Mg2+ binding site [ion binding]; other site 930782007561 G-X-G motif; other site 930782007562 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782007563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782007564 active site 930782007565 phosphorylation site [posttranslational modification] 930782007566 intermolecular recognition site; other site 930782007567 dimerization interface [polypeptide binding]; other site 930782007568 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782007569 DNA binding site [nucleotide binding] 930782007570 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 930782007571 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 930782007572 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930782007573 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 930782007574 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930782007575 putative active site [active] 930782007576 catalytic site [active] 930782007577 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930782007578 putative active site [active] 930782007579 catalytic site [active] 930782007580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930782007581 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 930782007582 Peptidase family M23; Region: Peptidase_M23; pfam01551 930782007583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 930782007584 NlpC/P60 family; Region: NLPC_P60; pfam00877 930782007585 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 930782007586 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 930782007587 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 930782007588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782007589 Walker A/P-loop; other site 930782007590 ATP binding site [chemical binding]; other site 930782007591 Q-loop/lid; other site 930782007592 ABC transporter signature motif; other site 930782007593 Walker B; other site 930782007594 D-loop; other site 930782007595 H-loop/switch region; other site 930782007596 Uncharacterized conserved protein [Function unknown]; Region: COG1284 930782007597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782007598 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 930782007599 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 930782007600 peptide chain release factor 2; Validated; Region: prfB; PRK00578 930782007601 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930782007602 RF-1 domain; Region: RF-1; pfam00472 930782007603 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 930782007604 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 930782007605 nucleotide binding region [chemical binding]; other site 930782007606 helicase superfamily c-terminal domain; Region: HELICc; smart00490 930782007607 ATP-binding site [chemical binding]; other site 930782007608 SEC-C motif; Region: SEC-C; pfam02810 930782007609 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 930782007610 30S subunit binding site; other site 930782007611 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 930782007612 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782007613 active site 930782007614 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 930782007615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782007616 ATP binding site [chemical binding]; other site 930782007617 putative Mg++ binding site [ion binding]; other site 930782007618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782007619 nucleotide binding region [chemical binding]; other site 930782007620 ATP-binding site [chemical binding]; other site 930782007621 EDD domain protein, DegV family; Region: DegV; TIGR00762 930782007622 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 930782007623 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 930782007624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782007625 active site 930782007626 phosphorylation site [posttranslational modification] 930782007627 intermolecular recognition site; other site 930782007628 dimerization interface [polypeptide binding]; other site 930782007629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 930782007630 DNA binding residues [nucleotide binding] 930782007631 dimerization interface [polypeptide binding]; other site 930782007632 Uncharacterized conserved protein [Function unknown]; Region: COG1739 930782007633 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 930782007634 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 930782007635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 930782007636 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 930782007637 Transcriptional regulator [Transcription]; Region: LytR; COG1316 930782007638 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 930782007639 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 930782007640 Mg++ binding site [ion binding]; other site 930782007641 putative catalytic motif [active] 930782007642 substrate binding site [chemical binding]; other site 930782007643 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 930782007644 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 930782007645 active site 930782007646 octamer interface [polypeptide binding]; other site 930782007647 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 930782007648 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 930782007649 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782007650 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782007651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930782007652 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930782007653 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930782007654 dimer interface [polypeptide binding]; other site 930782007655 ssDNA binding site [nucleotide binding]; other site 930782007656 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782007657 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 930782007658 rod shape-determining protein Mbl; Provisional; Region: PRK13928 930782007659 MreB and similar proteins; Region: MreB_like; cd10225 930782007660 nucleotide binding site [chemical binding]; other site 930782007661 Mg binding site [ion binding]; other site 930782007662 putative protofilament interaction site [polypeptide binding]; other site 930782007663 RodZ interaction site [polypeptide binding]; other site 930782007664 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930782007665 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930782007666 hinge; other site 930782007667 active site 930782007668 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 930782007669 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 930782007670 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930782007671 gamma subunit interface [polypeptide binding]; other site 930782007672 epsilon subunit interface [polypeptide binding]; other site 930782007673 LBP interface [polypeptide binding]; other site 930782007674 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 930782007675 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930782007676 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930782007677 alpha subunit interaction interface [polypeptide binding]; other site 930782007678 Walker A motif; other site 930782007679 ATP binding site [chemical binding]; other site 930782007680 Walker B motif; other site 930782007681 inhibitor binding site; inhibition site 930782007682 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930782007683 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930782007684 core domain interface [polypeptide binding]; other site 930782007685 delta subunit interface [polypeptide binding]; other site 930782007686 epsilon subunit interface [polypeptide binding]; other site 930782007687 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 930782007688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930782007689 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 930782007690 beta subunit interaction interface [polypeptide binding]; other site 930782007691 Walker A motif; other site 930782007692 ATP binding site [chemical binding]; other site 930782007693 Walker B motif; other site 930782007694 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930782007695 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 930782007696 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 930782007697 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 930782007698 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 930782007699 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 930782007700 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 930782007701 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 930782007702 ATP synthase I chain; Region: ATP_synt_I; pfam03899 930782007703 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 930782007704 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 930782007705 active site 930782007706 homodimer interface [polypeptide binding]; other site 930782007707 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782007708 active site 930782007709 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 930782007710 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 930782007711 dimer interface [polypeptide binding]; other site 930782007712 active site 930782007713 glycine-pyridoxal phosphate binding site [chemical binding]; other site 930782007714 folate binding site [chemical binding]; other site 930782007715 Low molecular weight phosphatase family; Region: LMWPc; cd00115 930782007716 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 930782007717 active site 930782007718 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 930782007719 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 930782007720 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 930782007721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782007722 S-adenosylmethionine binding site [chemical binding]; other site 930782007723 peptide chain release factor 1; Validated; Region: prfA; PRK00591 930782007724 This domain is found in peptide chain release factors; Region: PCRF; smart00937 930782007725 RF-1 domain; Region: RF-1; pfam00472 930782007726 thymidine kinase; Provisional; Region: PRK04296 930782007727 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930782007728 ATP binding site [chemical binding]; other site 930782007729 Walker A motif; other site 930782007730 Walker B motif; other site 930782007731 homoserine kinase; Provisional; Region: PRK01212 930782007732 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930782007733 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930782007734 threonine synthase; Reviewed; Region: PRK06721 930782007735 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 930782007736 homodimer interface [polypeptide binding]; other site 930782007737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782007738 catalytic residue [active] 930782007739 homoserine dehydrogenase; Provisional; Region: PRK06349 930782007740 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 930782007741 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 930782007742 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 930782007743 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 930782007744 Predicted membrane protein [Function unknown]; Region: COG2246 930782007745 GtrA-like protein; Region: GtrA; pfam04138 930782007746 transcription termination factor Rho; Provisional; Region: rho; PRK09376 930782007747 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 930782007748 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 930782007749 RNA binding site [nucleotide binding]; other site 930782007750 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 930782007751 multimer interface [polypeptide binding]; other site 930782007752 Walker A motif; other site 930782007753 ATP binding site [chemical binding]; other site 930782007754 Walker B motif; other site 930782007755 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 930782007756 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 930782007757 hinge; other site 930782007758 active site 930782007759 Predicted integral membrane protein [Function unknown]; Region: COG0392 930782007760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930782007761 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 930782007762 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 930782007763 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 930782007764 putative ADP-binding pocket [chemical binding]; other site 930782007765 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 930782007766 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 930782007767 intersubunit interface [polypeptide binding]; other site 930782007768 active site 930782007769 zinc binding site [ion binding]; other site 930782007770 Na+ binding site [ion binding]; other site 930782007771 putative lipid kinase; Reviewed; Region: PRK13055 930782007772 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 930782007773 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 930782007774 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 930782007775 substrate binding site [chemical binding]; other site 930782007776 SH3-like domain; Region: SH3_8; pfam13457 930782007777 SH3-like domain; Region: SH3_8; pfam13457 930782007778 SH3-like domain; Region: SH3_8; pfam13457 930782007779 CTP synthetase; Validated; Region: pyrG; PRK05380 930782007780 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 930782007781 Catalytic site [active] 930782007782 active site 930782007783 UTP binding site [chemical binding]; other site 930782007784 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 930782007785 active site 930782007786 putative oxyanion hole; other site 930782007787 catalytic triad [active] 930782007788 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 930782007789 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 930782007790 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 930782007791 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 930782007792 active site 930782007793 HIGH motif; other site 930782007794 KMSK motif region; other site 930782007795 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 930782007796 tRNA binding surface [nucleotide binding]; other site 930782007797 anticodon binding site; other site 930782007798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 930782007799 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 930782007800 Peptidase family M50; Region: Peptidase_M50; pfam02163 930782007801 active site 930782007802 putative substrate binding region [chemical binding]; other site 930782007803 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 930782007804 active site 1 [active] 930782007805 dimer interface [polypeptide binding]; other site 930782007806 hexamer interface [polypeptide binding]; other site 930782007807 active site 2 [active] 930782007808 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 930782007809 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782007810 Zn2+ binding site [ion binding]; other site 930782007811 Mg2+ binding site [ion binding]; other site 930782007812 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 930782007813 conserved hypothetical protein TIGR01655; Region: yxeA_fam 930782007814 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930782007815 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930782007816 peptide binding site [polypeptide binding]; other site 930782007817 Predicted integral membrane protein [Function unknown]; Region: COG5658 930782007818 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 930782007819 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 930782007820 catalytic triad [active] 930782007821 metal binding site [ion binding]; metal-binding site 930782007822 conserved cis-peptide bond; other site 930782007823 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 930782007824 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 930782007825 folate binding site [chemical binding]; other site 930782007826 NADP+ binding site [chemical binding]; other site 930782007827 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 930782007828 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 930782007829 putative NAD(P) binding site [chemical binding]; other site 930782007830 dimer interface [polypeptide binding]; other site 930782007831 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 930782007832 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 930782007833 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782007834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782007835 active site 930782007836 motif I; other site 930782007837 motif II; other site 930782007838 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 930782007839 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930782007840 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782007841 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782007842 Walker A/P-loop; other site 930782007843 ATP binding site [chemical binding]; other site 930782007844 Q-loop/lid; other site 930782007845 ABC transporter signature motif; other site 930782007846 Walker B; other site 930782007847 D-loop; other site 930782007848 H-loop/switch region; other site 930782007849 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782007850 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782007851 FtsX-like permease family; Region: FtsX; pfam02687 930782007852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 930782007853 dimerization interface [polypeptide binding]; other site 930782007854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782007855 dimer interface [polypeptide binding]; other site 930782007856 phosphorylation site [posttranslational modification] 930782007857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782007858 ATP binding site [chemical binding]; other site 930782007859 Mg2+ binding site [ion binding]; other site 930782007860 G-X-G motif; other site 930782007861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782007862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782007863 active site 930782007864 phosphorylation site [posttranslational modification] 930782007865 intermolecular recognition site; other site 930782007866 dimerization interface [polypeptide binding]; other site 930782007867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782007868 DNA binding site [nucleotide binding] 930782007869 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 930782007870 Uncharacterized conserved protein [Function unknown]; Region: COG2427 930782007871 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 930782007872 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 930782007873 catalytic loop [active] 930782007874 iron binding site [ion binding]; other site 930782007875 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 930782007876 4Fe-4S binding domain; Region: Fer4; pfam00037 930782007877 4Fe-4S binding domain; Region: Fer4; pfam00037 930782007878 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 930782007879 [4Fe-4S] binding site [ion binding]; other site 930782007880 molybdopterin cofactor binding site; other site 930782007881 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 930782007882 molybdopterin cofactor binding site; other site 930782007883 Uncharacterized conserved protein [Function unknown]; Region: COG1912 930782007884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782007885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782007886 putative substrate translocation pore; other site 930782007887 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782007888 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782007889 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 930782007890 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 930782007891 Walker A motif; other site 930782007892 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782007893 SH3-like domain; Region: SH3_8; pfam13457 930782007894 SH3-like domain; Region: SH3_8; pfam13457 930782007895 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782007896 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782007897 active site 930782007898 catalytic tetrad [active] 930782007899 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782007900 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782007901 DNA binding residues [nucleotide binding] 930782007902 putative dimer interface [polypeptide binding]; other site 930782007903 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 930782007904 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 930782007905 23S rRNA interface [nucleotide binding]; other site 930782007906 L3 interface [polypeptide binding]; other site 930782007907 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 930782007908 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 930782007909 dimerization interface 3.5A [polypeptide binding]; other site 930782007910 active site 930782007911 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930782007912 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 930782007913 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930782007914 Walker A/P-loop; other site 930782007915 ATP binding site [chemical binding]; other site 930782007916 Q-loop/lid; other site 930782007917 ABC transporter signature motif; other site 930782007918 Walker B; other site 930782007919 D-loop; other site 930782007920 H-loop/switch region; other site 930782007921 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 930782007922 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 930782007923 Walker A/P-loop; other site 930782007924 ATP binding site [chemical binding]; other site 930782007925 Q-loop/lid; other site 930782007926 ABC transporter signature motif; other site 930782007927 Walker B; other site 930782007928 D-loop; other site 930782007929 H-loop/switch region; other site 930782007930 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 930782007931 MgtC family; Region: MgtC; pfam02308 930782007932 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 930782007933 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 930782007934 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 930782007935 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 930782007936 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 930782007937 alphaNTD - beta interaction site [polypeptide binding]; other site 930782007938 alphaNTD homodimer interface [polypeptide binding]; other site 930782007939 alphaNTD - beta' interaction site [polypeptide binding]; other site 930782007940 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 930782007941 30S ribosomal protein S11; Validated; Region: PRK05309 930782007942 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 930782007943 30S ribosomal protein S13; Region: bact_S13; TIGR03631 930782007944 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 930782007945 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 930782007946 rRNA binding site [nucleotide binding]; other site 930782007947 predicted 30S ribosome binding site; other site 930782007948 adenylate kinase; Reviewed; Region: adk; PRK00279 930782007949 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 930782007950 AMP-binding site [chemical binding]; other site 930782007951 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 930782007952 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 930782007953 SecY translocase; Region: SecY; pfam00344 930782007954 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 930782007955 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 930782007956 23S rRNA binding site [nucleotide binding]; other site 930782007957 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 930782007958 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 930782007959 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 930782007960 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 930782007961 5S rRNA interface [nucleotide binding]; other site 930782007962 L27 interface [polypeptide binding]; other site 930782007963 23S rRNA interface [nucleotide binding]; other site 930782007964 L5 interface [polypeptide binding]; other site 930782007965 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 930782007966 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930782007967 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 930782007968 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 930782007969 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 930782007970 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 930782007971 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 930782007972 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 930782007973 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 930782007974 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 930782007975 RNA binding site [nucleotide binding]; other site 930782007976 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 930782007977 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 930782007978 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 930782007979 23S rRNA interface [nucleotide binding]; other site 930782007980 putative translocon interaction site; other site 930782007981 signal recognition particle (SRP54) interaction site; other site 930782007982 L23 interface [polypeptide binding]; other site 930782007983 trigger factor interaction site; other site 930782007984 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 930782007985 23S rRNA interface [nucleotide binding]; other site 930782007986 5S rRNA interface [nucleotide binding]; other site 930782007987 putative antibiotic binding site [chemical binding]; other site 930782007988 L25 interface [polypeptide binding]; other site 930782007989 L27 interface [polypeptide binding]; other site 930782007990 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 930782007991 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 930782007992 G-X-X-G motif; other site 930782007993 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 930782007994 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 930782007995 putative translocon binding site; other site 930782007996 protein-rRNA interface [nucleotide binding]; other site 930782007997 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 930782007998 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 930782007999 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 930782008000 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 930782008001 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 930782008002 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 930782008003 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 930782008004 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 930782008005 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 930782008006 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 930782008007 UbiA prenyltransferase family; Region: UbiA; pfam01040 930782008008 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 930782008009 ApbE family; Region: ApbE; pfam02424 930782008010 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 930782008011 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 930782008012 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 930782008013 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 930782008014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 930782008015 Predicted membrane protein [Function unknown]; Region: COG2259 930782008016 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 930782008017 trimer interface [polypeptide binding]; other site 930782008018 Predicted membrane protein [Function unknown]; Region: COG4769 930782008019 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 930782008020 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 930782008021 substrate binding pocket [chemical binding]; other site 930782008022 chain length determination region; other site 930782008023 substrate-Mg2+ binding site; other site 930782008024 catalytic residues [active] 930782008025 aspartate-rich region 1; other site 930782008026 active site lid residues [active] 930782008027 aspartate-rich region 2; other site 930782008028 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 930782008029 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 930782008030 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 930782008031 active site 930782008032 metal binding site [ion binding]; metal-binding site 930782008033 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 930782008034 hypothetical protein; Provisional; Region: PRK02947 930782008035 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008036 putative active site [active] 930782008037 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 930782008038 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 930782008039 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 930782008040 active site 930782008041 substrate binding pocket [chemical binding]; other site 930782008042 homodimer interaction site [polypeptide binding]; other site 930782008043 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 930782008044 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 930782008045 active site 930782008046 P-loop; other site 930782008047 phosphorylation site [posttranslational modification] 930782008048 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782008049 active site 930782008050 phosphorylation site [posttranslational modification] 930782008051 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782008052 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782008053 PRD domain; Region: PRD; pfam00874 930782008054 PRD domain; Region: PRD; pfam00874 930782008055 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782008056 active site 930782008057 P-loop; other site 930782008058 phosphorylation site [posttranslational modification] 930782008059 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782008060 active site 930782008061 phosphorylation site [posttranslational modification] 930782008062 elongation factor Tu; Reviewed; Region: PRK00049 930782008063 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 930782008064 G1 box; other site 930782008065 GEF interaction site [polypeptide binding]; other site 930782008066 GTP/Mg2+ binding site [chemical binding]; other site 930782008067 Switch I region; other site 930782008068 G2 box; other site 930782008069 G3 box; other site 930782008070 Switch II region; other site 930782008071 G4 box; other site 930782008072 G5 box; other site 930782008073 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 930782008074 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 930782008075 Antibiotic Binding Site [chemical binding]; other site 930782008076 elongation factor G; Reviewed; Region: PRK00007 930782008077 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 930782008078 G1 box; other site 930782008079 putative GEF interaction site [polypeptide binding]; other site 930782008080 GTP/Mg2+ binding site [chemical binding]; other site 930782008081 Switch I region; other site 930782008082 G2 box; other site 930782008083 G3 box; other site 930782008084 Switch II region; other site 930782008085 G4 box; other site 930782008086 G5 box; other site 930782008087 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 930782008088 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 930782008089 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 930782008090 30S ribosomal protein S7; Validated; Region: PRK05302 930782008091 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 930782008092 S17 interaction site [polypeptide binding]; other site 930782008093 S8 interaction site; other site 930782008094 16S rRNA interaction site [nucleotide binding]; other site 930782008095 streptomycin interaction site [chemical binding]; other site 930782008096 23S rRNA interaction site [nucleotide binding]; other site 930782008097 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 930782008098 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 930782008099 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 930782008100 Zn2+ binding site [ion binding]; other site 930782008101 Mg2+ binding site [ion binding]; other site 930782008102 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 930782008103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782008104 Coenzyme A binding pocket [chemical binding]; other site 930782008105 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 930782008106 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008107 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008108 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930782008109 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930782008110 substrate binding site [chemical binding]; other site 930782008111 hexamer interface [polypeptide binding]; other site 930782008112 metal binding site [ion binding]; metal-binding site 930782008113 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 930782008114 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 930782008115 TPP-binding site [chemical binding]; other site 930782008116 dimer interface [polypeptide binding]; other site 930782008117 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 930782008118 PYR/PP interface [polypeptide binding]; other site 930782008119 dimer interface [polypeptide binding]; other site 930782008120 TPP binding site [chemical binding]; other site 930782008121 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 930782008122 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 930782008123 substrate binding site [chemical binding]; other site 930782008124 hexamer interface [polypeptide binding]; other site 930782008125 metal binding site [ion binding]; metal-binding site 930782008126 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 930782008127 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930782008128 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 930782008129 putative NAD(P) binding site [chemical binding]; other site 930782008130 catalytic Zn binding site [ion binding]; other site 930782008131 structural Zn binding site [ion binding]; other site 930782008132 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930782008133 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 930782008134 putative NAD(P) binding site [chemical binding]; other site 930782008135 catalytic Zn binding site [ion binding]; other site 930782008136 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 930782008137 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 930782008138 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 930782008139 active site 930782008140 P-loop; other site 930782008141 phosphorylation site [posttranslational modification] 930782008142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782008143 active site 930782008144 phosphorylation site [posttranslational modification] 930782008145 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782008146 PRD domain; Region: PRD; pfam00874 930782008147 PRD domain; Region: PRD; pfam00874 930782008148 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782008149 active site 930782008150 P-loop; other site 930782008151 phosphorylation site [posttranslational modification] 930782008152 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 930782008153 active site 930782008154 phosphorylation site [posttranslational modification] 930782008155 Predicted membrane protein [Function unknown]; Region: COG4905 930782008156 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 930782008157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 930782008158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 930782008159 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 930782008160 active site 930782008161 Helix-turn-helix domain; Region: HTH_18; pfam12833 930782008162 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 930782008163 Ligand Binding Site [chemical binding]; other site 930782008164 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 930782008165 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 930782008166 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 930782008167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782008168 active site 930782008169 phosphorylation site [posttranslational modification] 930782008170 intermolecular recognition site; other site 930782008171 dimerization interface [polypeptide binding]; other site 930782008172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 930782008173 DNA binding site [nucleotide binding] 930782008174 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 930782008175 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 930782008176 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 930782008177 Ligand Binding Site [chemical binding]; other site 930782008178 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 930782008179 GAF domain; Region: GAF_3; pfam13492 930782008180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 930782008181 dimer interface [polypeptide binding]; other site 930782008182 phosphorylation site [posttranslational modification] 930782008183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782008184 ATP binding site [chemical binding]; other site 930782008185 Mg2+ binding site [ion binding]; other site 930782008186 G-X-G motif; other site 930782008187 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 930782008188 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 930782008189 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782008190 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 930782008191 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782008192 active site 930782008193 P-loop; other site 930782008194 phosphorylation site [posttranslational modification] 930782008195 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782008196 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782008197 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782008198 methionine cluster; other site 930782008199 active site 930782008200 phosphorylation site [posttranslational modification] 930782008201 metal binding site [ion binding]; metal-binding site 930782008202 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 930782008203 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 930782008204 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 930782008205 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 930782008206 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 930782008207 Soluble P-type ATPase [General function prediction only]; Region: COG4087 930782008208 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 930782008209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782008210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782008211 autolysin; Reviewed; Region: PRK06347 930782008212 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 930782008213 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782008214 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782008215 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782008216 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 930782008217 Protein of unknown function (DUF970); Region: DUF970; pfam06153 930782008218 thymidylate kinase; Validated; Region: tmk; PRK00698 930782008219 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 930782008220 TMP-binding site; other site 930782008221 ATP-binding site [chemical binding]; other site 930782008222 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 930782008223 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 930782008224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782008225 catalytic residue [active] 930782008226 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 930782008227 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 930782008228 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930782008229 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 930782008230 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 930782008231 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 930782008232 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782008233 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782008234 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008235 putative active site [active] 930782008236 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782008237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008238 active site 930782008239 motif I; other site 930782008240 motif II; other site 930782008241 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930782008242 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 930782008243 nudix motif; other site 930782008244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782008245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782008246 active site 930782008247 catalytic tetrad [active] 930782008248 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 930782008249 recombination protein RecR; Reviewed; Region: recR; PRK00076 930782008250 RecR protein; Region: RecR; pfam02132 930782008251 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 930782008252 putative active site [active] 930782008253 putative metal-binding site [ion binding]; other site 930782008254 tetramer interface [polypeptide binding]; other site 930782008255 hypothetical protein; Validated; Region: PRK00153 930782008256 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 930782008257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782008258 Walker A motif; other site 930782008259 ATP binding site [chemical binding]; other site 930782008260 Walker B motif; other site 930782008261 arginine finger; other site 930782008262 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 930782008263 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 930782008264 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 930782008265 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782008266 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782008267 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 930782008268 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 930782008269 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 930782008270 N- and C-terminal domain interface [polypeptide binding]; other site 930782008271 active site 930782008272 catalytic site [active] 930782008273 metal binding site [ion binding]; metal-binding site 930782008274 carbohydrate binding site [chemical binding]; other site 930782008275 ATP binding site [chemical binding]; other site 930782008276 SH3-like domain; Region: SH3_8; pfam13457 930782008277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 930782008278 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 930782008279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782008280 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 930782008281 Walker A/P-loop; other site 930782008282 ATP binding site [chemical binding]; other site 930782008283 Q-loop/lid; other site 930782008284 ABC transporter signature motif; other site 930782008285 Walker B; other site 930782008286 D-loop; other site 930782008287 H-loop/switch region; other site 930782008288 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 930782008289 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782008290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008291 Walker A/P-loop; other site 930782008292 ATP binding site [chemical binding]; other site 930782008293 Q-loop/lid; other site 930782008294 ABC transporter signature motif; other site 930782008295 Walker B; other site 930782008296 D-loop; other site 930782008297 H-loop/switch region; other site 930782008298 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 930782008299 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 930782008300 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 930782008301 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 930782008302 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 930782008303 nucleoside/Zn binding site; other site 930782008304 dimer interface [polypeptide binding]; other site 930782008305 catalytic motif [active] 930782008306 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 930782008307 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 930782008308 active site 930782008309 acyl-activating enzyme (AAE) consensus motif; other site 930782008310 putative CoA binding site [chemical binding]; other site 930782008311 AMP binding site [chemical binding]; other site 930782008312 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 930782008313 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 930782008314 active site 930782008315 trimer interface [polypeptide binding]; other site 930782008316 allosteric site; other site 930782008317 active site lid [active] 930782008318 hexamer (dimer of trimers) interface [polypeptide binding]; other site 930782008319 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 930782008320 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 930782008321 DNA binding residues [nucleotide binding] 930782008322 drug binding residues [chemical binding]; other site 930782008323 dimer interface [polypeptide binding]; other site 930782008324 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 930782008325 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 930782008326 Coenzyme A binding pocket [chemical binding]; other site 930782008327 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 930782008328 dimer interface [polypeptide binding]; other site 930782008329 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930782008330 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 930782008331 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 930782008332 MarR family; Region: MarR; pfam01047 930782008333 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 930782008334 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 930782008335 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782008336 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782008337 DNA binding residues [nucleotide binding] 930782008338 putative dimer interface [polypeptide binding]; other site 930782008339 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 930782008340 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 930782008341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008342 active site 930782008343 motif I; other site 930782008344 motif II; other site 930782008345 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782008346 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782008347 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008348 putative active site [active] 930782008349 alpha-mannosidase; Provisional; Region: PRK09819 930782008350 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 930782008351 active site 930782008352 metal binding site [ion binding]; metal-binding site 930782008353 catalytic site [active] 930782008354 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 930782008355 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 930782008356 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 930782008357 active site 930782008358 homodimer interface [polypeptide binding]; other site 930782008359 catalytic site [active] 930782008360 glycerate kinase; Region: TIGR00045 930782008361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782008362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782008363 DNA binding site [nucleotide binding] 930782008364 domain linker motif; other site 930782008365 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 930782008366 putative dimerization interface [polypeptide binding]; other site 930782008367 putative ligand binding site [chemical binding]; other site 930782008368 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 930782008369 Domain of unknown function DUF21; Region: DUF21; pfam01595 930782008370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 930782008371 Transporter associated domain; Region: CorC_HlyC; pfam03471 930782008372 NAD-dependent deacetylase; Provisional; Region: PRK00481 930782008373 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 930782008374 NAD+ binding site [chemical binding]; other site 930782008375 substrate binding site [chemical binding]; other site 930782008376 putative Zn binding site [ion binding]; other site 930782008377 Pathogenicity locus; Region: Cdd1; pfam11731 930782008378 drug efflux system protein MdtG; Provisional; Region: PRK09874 930782008379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008380 putative substrate translocation pore; other site 930782008381 Src Homology 3 domain superfamily; Region: SH3; cl17036 930782008382 Variant SH3 domain; Region: SH3_2; pfam07653 930782008383 peptide ligand binding site [polypeptide binding]; other site 930782008384 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 930782008385 active site 930782008386 intersubunit interactions; other site 930782008387 catalytic residue [active] 930782008388 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782008389 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782008390 ligand binding site [chemical binding]; other site 930782008391 flexible hinge region; other site 930782008392 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782008393 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782008394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782008395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008396 Walker A/P-loop; other site 930782008397 ATP binding site [chemical binding]; other site 930782008398 Q-loop/lid; other site 930782008399 ABC transporter signature motif; other site 930782008400 Walker B; other site 930782008401 D-loop; other site 930782008402 H-loop/switch region; other site 930782008403 TfoX C-terminal domain; Region: TfoX_C; pfam04994 930782008404 seryl-tRNA synthetase; Provisional; Region: PRK05431 930782008405 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 930782008406 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 930782008407 dimer interface [polypeptide binding]; other site 930782008408 active site 930782008409 motif 1; other site 930782008410 motif 2; other site 930782008411 motif 3; other site 930782008412 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 930782008413 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 930782008414 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 930782008415 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 930782008416 glutamine binding [chemical binding]; other site 930782008417 catalytic triad [active] 930782008418 aminodeoxychorismate synthase; Provisional; Region: PRK07508 930782008419 chorismate binding enzyme; Region: Chorismate_bind; cl10555 930782008420 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 930782008421 substrate-cofactor binding pocket; other site 930782008422 homodimer interface [polypeptide binding]; other site 930782008423 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 930782008424 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782008425 catalytic residue [active] 930782008426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782008427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782008428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008429 Walker A/P-loop; other site 930782008430 ATP binding site [chemical binding]; other site 930782008431 Q-loop/lid; other site 930782008432 ABC transporter signature motif; other site 930782008433 Walker B; other site 930782008434 D-loop; other site 930782008435 H-loop/switch region; other site 930782008436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782008437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782008438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008439 Walker A/P-loop; other site 930782008440 ATP binding site [chemical binding]; other site 930782008441 Q-loop/lid; other site 930782008442 ABC transporter signature motif; other site 930782008443 Walker B; other site 930782008444 D-loop; other site 930782008445 H-loop/switch region; other site 930782008446 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 930782008447 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 930782008448 Ligand binding site; other site 930782008449 Putative Catalytic site; other site 930782008450 DXD motif; other site 930782008451 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 930782008452 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930782008453 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 930782008454 Predicted acyl esterases [General function prediction only]; Region: COG2936 930782008455 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 930782008456 DNA topoisomerase III; Provisional; Region: PRK07726 930782008457 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 930782008458 active site 930782008459 putative interdomain interaction site [polypeptide binding]; other site 930782008460 putative metal-binding site [ion binding]; other site 930782008461 putative nucleotide binding site [chemical binding]; other site 930782008462 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 930782008463 domain I; other site 930782008464 DNA binding groove [nucleotide binding] 930782008465 phosphate binding site [ion binding]; other site 930782008466 domain II; other site 930782008467 domain III; other site 930782008468 nucleotide binding site [chemical binding]; other site 930782008469 catalytic site [active] 930782008470 domain IV; other site 930782008471 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 930782008472 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 930782008473 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782008474 ATP binding site [chemical binding]; other site 930782008475 putative Mg++ binding site [ion binding]; other site 930782008476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782008477 nucleotide binding region [chemical binding]; other site 930782008478 ATP-binding site [chemical binding]; other site 930782008479 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 930782008480 HRDC domain; Region: HRDC; pfam00570 930782008481 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 930782008482 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 930782008483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 930782008484 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930782008485 active site 930782008486 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 930782008487 putative ADP-ribose binding site [chemical binding]; other site 930782008488 putative active site [active] 930782008489 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 930782008490 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782008491 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782008492 ABC transporter; Region: ABC_tran_2; pfam12848 930782008493 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 930782008494 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 930782008495 beta-galactosidase; Region: BGL; TIGR03356 930782008496 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782008497 active site 930782008498 P-loop; other site 930782008499 phosphorylation site [posttranslational modification] 930782008500 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782008501 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782008502 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782008503 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782008504 nucleotide binding site [chemical binding]; other site 930782008505 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782008506 methionine cluster; other site 930782008507 active site 930782008508 phosphorylation site [posttranslational modification] 930782008509 metal binding site [ion binding]; metal-binding site 930782008510 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782008511 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782008512 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008513 putative active site [active] 930782008514 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 930782008515 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 930782008516 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 930782008517 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 930782008518 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 930782008519 Walker A/P-loop; other site 930782008520 ATP binding site [chemical binding]; other site 930782008521 Q-loop/lid; other site 930782008522 ABC transporter signature motif; other site 930782008523 Walker B; other site 930782008524 D-loop; other site 930782008525 H-loop/switch region; other site 930782008526 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 930782008527 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 930782008528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 930782008529 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930782008530 beta-galactosidase; Region: BGL; TIGR03356 930782008531 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 930782008532 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930782008533 active site turn [active] 930782008534 phosphorylation site [posttranslational modification] 930782008535 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930782008536 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930782008537 HPr interaction site; other site 930782008538 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930782008539 active site 930782008540 phosphorylation site [posttranslational modification] 930782008541 transcriptional antiterminator BglG; Provisional; Region: PRK09772 930782008542 CAT RNA binding domain; Region: CAT_RBD; smart01061 930782008543 PRD domain; Region: PRD; pfam00874 930782008544 PRD domain; Region: PRD; pfam00874 930782008545 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782008546 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 930782008547 Walker A/P-loop; other site 930782008548 ATP binding site [chemical binding]; other site 930782008549 Q-loop/lid; other site 930782008550 ABC transporter signature motif; other site 930782008551 Walker B; other site 930782008552 D-loop; other site 930782008553 H-loop/switch region; other site 930782008554 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 930782008555 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 930782008556 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 930782008557 GTP-binding protein YchF; Reviewed; Region: PRK09601 930782008558 YchF GTPase; Region: YchF; cd01900 930782008559 G1 box; other site 930782008560 GTP/Mg2+ binding site [chemical binding]; other site 930782008561 Switch I region; other site 930782008562 G2 box; other site 930782008563 Switch II region; other site 930782008564 G3 box; other site 930782008565 G4 box; other site 930782008566 G5 box; other site 930782008567 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 930782008568 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 930782008569 methionine cluster; other site 930782008570 active site 930782008571 phosphorylation site [posttranslational modification] 930782008572 metal binding site [ion binding]; metal-binding site 930782008573 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 930782008574 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 930782008575 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 930782008576 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 930782008577 active site 930782008578 P-loop; other site 930782008579 phosphorylation site [posttranslational modification] 930782008580 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782008581 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 930782008582 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 930782008583 HTH domain; Region: HTH_11; pfam08279 930782008584 Mga helix-turn-helix domain; Region: Mga; pfam05043 930782008585 PRD domain; Region: PRD; pfam00874 930782008586 PRD domain; Region: PRD; pfam00874 930782008587 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 930782008588 active site 930782008589 P-loop; other site 930782008590 phosphorylation site [posttranslational modification] 930782008591 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782008592 active site 930782008593 phosphorylation site [posttranslational modification] 930782008594 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 930782008595 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 930782008596 tetramer interface [polypeptide binding]; other site 930782008597 heme binding pocket [chemical binding]; other site 930782008598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 930782008599 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 930782008600 ParB-like nuclease domain; Region: ParB; smart00470 930782008601 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 930782008602 salt bridge; other site 930782008603 non-specific DNA binding site [nucleotide binding]; other site 930782008604 sequence-specific DNA binding site [nucleotide binding]; other site 930782008605 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 930782008606 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930782008607 P-loop; other site 930782008608 Magnesium ion binding site [ion binding]; other site 930782008609 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 930782008610 Magnesium ion binding site [ion binding]; other site 930782008611 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 930782008612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782008613 non-specific DNA binding site [nucleotide binding]; other site 930782008614 salt bridge; other site 930782008615 sequence-specific DNA binding site [nucleotide binding]; other site 930782008616 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 930782008617 ParB-like nuclease domain; Region: ParBc; pfam02195 930782008618 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782008619 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782008620 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008621 putative active site [active] 930782008622 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782008623 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782008624 nucleotide binding site [chemical binding]; other site 930782008625 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 930782008626 active site 930782008627 phosphorylation site [posttranslational modification] 930782008628 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 930782008629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008630 motif II; other site 930782008631 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 930782008632 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 930782008633 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 930782008634 active site 930782008635 P-loop; other site 930782008636 phosphorylation site [posttranslational modification] 930782008637 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782008638 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782008639 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930782008640 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 930782008641 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 930782008642 putative active site cavity [active] 930782008643 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 930782008644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782008645 S-adenosylmethionine binding site [chemical binding]; other site 930782008646 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930782008647 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930782008648 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930782008649 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 930782008650 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 930782008651 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 930782008652 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 930782008653 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 930782008654 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 930782008655 trmE is a tRNA modification GTPase; Region: trmE; cd04164 930782008656 G1 box; other site 930782008657 GTP/Mg2+ binding site [chemical binding]; other site 930782008658 Switch I region; other site 930782008659 G2 box; other site 930782008660 Switch II region; other site 930782008661 G3 box; other site 930782008662 G4 box; other site 930782008663 G5 box; other site 930782008664 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 930782008665 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 930782008666 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 930782008667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 930782008668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 930782008669 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 930782008670 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 930782008671 NADP binding site [chemical binding]; other site 930782008672 homodimer interface [polypeptide binding]; other site 930782008673 active site 930782008674 substrate binding site [chemical binding]; other site 930782008675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008676 D-galactonate transporter; Region: 2A0114; TIGR00893 930782008677 putative substrate translocation pore; other site 930782008678 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930782008679 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930782008680 metal binding site [ion binding]; metal-binding site 930782008681 dimer interface [polypeptide binding]; other site 930782008682 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 930782008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 930782008684 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 930782008685 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 930782008686 metal binding site [ion binding]; metal-binding site 930782008687 dimer interface [polypeptide binding]; other site 930782008688 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782008689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782008690 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 930782008691 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 930782008692 Leucine-rich repeats; other site 930782008693 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782008694 Substrate binding site [chemical binding]; other site 930782008695 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 930782008696 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008697 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008698 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008699 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008700 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782008701 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 930782008702 Uncharacterized conserved protein [Function unknown]; Region: COG4198 930782008703 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 930782008704 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 930782008705 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 930782008706 putative ligand binding site [chemical binding]; other site 930782008707 putative NAD binding site [chemical binding]; other site 930782008708 putative catalytic site [active] 930782008709 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 930782008710 L-serine binding site [chemical binding]; other site 930782008711 ACT domain interface; other site 930782008712 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 930782008713 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 930782008714 catalytic residue [active] 930782008715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782008717 putative substrate translocation pore; other site 930782008718 Transcriptional regulators [Transcription]; Region: MarR; COG1846 930782008719 MarR family; Region: MarR_2; pfam12802 930782008720 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 930782008721 dimer interface [polypeptide binding]; other site 930782008722 FMN binding site [chemical binding]; other site 930782008723 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 930782008724 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 930782008725 catalytic residues [active] 930782008726 beta-phosphoglucomutase; Region: bPGM; TIGR01990 930782008727 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 930782008728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008729 motif II; other site 930782008730 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 930782008731 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 930782008732 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 930782008733 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 930782008734 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 930782008735 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 930782008736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 930782008737 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 930782008738 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 930782008739 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 930782008740 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 930782008741 putative NAD(P) binding site [chemical binding]; other site 930782008742 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782008743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782008744 dimer interface [polypeptide binding]; other site 930782008745 conserved gate region; other site 930782008746 putative PBP binding loops; other site 930782008747 ABC-ATPase subunit interface; other site 930782008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782008749 dimer interface [polypeptide binding]; other site 930782008750 conserved gate region; other site 930782008751 putative PBP binding loops; other site 930782008752 ABC-ATPase subunit interface; other site 930782008753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930782008754 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782008755 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 930782008756 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 930782008757 active site 930782008758 homodimer interface [polypeptide binding]; other site 930782008759 catalytic site [active] 930782008760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782008761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782008762 DNA binding site [nucleotide binding] 930782008763 domain linker motif; other site 930782008764 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 930782008765 putative dimerization interface [polypeptide binding]; other site 930782008766 putative ligand binding site [chemical binding]; other site 930782008767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930782008768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782008769 Coenzyme A binding pocket [chemical binding]; other site 930782008770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782008772 putative substrate translocation pore; other site 930782008773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008774 Domain of unknown function (DUF718); Region: DUF718; cl01281 930782008775 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 930782008776 intersubunit interface [polypeptide binding]; other site 930782008777 active site 930782008778 Zn2+ binding site [ion binding]; other site 930782008779 L-rhamnose isomerase; Provisional; Region: PRK01076 930782008780 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 930782008781 N- and C-terminal domain interface [polypeptide binding]; other site 930782008782 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 930782008783 active site 930782008784 putative catalytic site [active] 930782008785 metal binding site [ion binding]; metal-binding site 930782008786 ATP binding site [chemical binding]; other site 930782008787 carbohydrate binding site [chemical binding]; other site 930782008788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 930782008789 putative substrate translocation pore; other site 930782008790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 930782008791 Cupin domain; Region: Cupin_2; pfam07883 930782008792 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782008793 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 930782008794 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 930782008795 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 930782008796 G-X-X-G motif; other site 930782008797 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 930782008798 RxxxH motif; other site 930782008799 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 930782008800 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 930782008801 ribonuclease P; Reviewed; Region: rnpA; PRK00499 930782008802 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 930782008803 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 930782008804 DnaA N-terminal domain; Region: DnaA_N; pfam11638 930782008805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782008806 Walker A motif; other site 930782008807 ATP binding site [chemical binding]; other site 930782008808 Walker B motif; other site 930782008809 arginine finger; other site 930782008810 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 930782008811 DnaA box-binding interface [nucleotide binding]; other site 930782008812 DNA polymerase III subunit beta; Validated; Region: PRK05643 930782008813 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 930782008814 putative DNA binding surface [nucleotide binding]; other site 930782008815 dimer interface [polypeptide binding]; other site 930782008816 beta-clamp/clamp loader binding surface; other site 930782008817 beta-clamp/translesion DNA polymerase binding surface; other site 930782008818 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 930782008819 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 930782008820 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 930782008821 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 930782008822 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 930782008823 Walker A/P-loop; other site 930782008824 ATP binding site [chemical binding]; other site 930782008825 Q-loop/lid; other site 930782008826 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008827 ABC transporter signature motif; other site 930782008828 Walker B; other site 930782008829 D-loop; other site 930782008830 H-loop/switch region; other site 930782008831 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 930782008832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782008833 Mg2+ binding site [ion binding]; other site 930782008834 G-X-G motif; other site 930782008835 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 930782008836 anchoring element; other site 930782008837 dimer interface [polypeptide binding]; other site 930782008838 ATP binding site [chemical binding]; other site 930782008839 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 930782008840 active site 930782008841 putative metal-binding site [ion binding]; other site 930782008842 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 930782008843 DNA gyrase subunit A; Validated; Region: PRK05560 930782008844 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 930782008845 CAP-like domain; other site 930782008846 active site 930782008847 primary dimer interface [polypeptide binding]; other site 930782008848 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782008849 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782008850 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782008851 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782008852 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 930782008853 cardiolipin synthetase; Reviewed; Region: PRK12452 930782008854 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 930782008855 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 930782008856 putative active site [active] 930782008857 catalytic site [active] 930782008858 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 930782008859 putative active site [active] 930782008860 catalytic site [active] 930782008861 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 930782008862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782008863 Coenzyme A binding pocket [chemical binding]; other site 930782008864 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 930782008865 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930782008866 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930782008867 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 930782008868 diphosphomevalonate decarboxylase; Region: PLN02407 930782008869 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 930782008870 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 930782008871 SH3-like domain; Region: SH3_8; pfam13457 930782008872 SH3-like domain; Region: SH3_8; pfam13457 930782008873 SH3-like domain; Region: SH3_8; pfam13457 930782008874 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 930782008875 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 930782008876 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 930782008877 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 930782008878 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 930782008879 D-pathway; other site 930782008880 Putative ubiquinol binding site [chemical binding]; other site 930782008881 Low-spin heme (heme b) binding site [chemical binding]; other site 930782008882 Putative water exit pathway; other site 930782008883 Binuclear center (heme o3/CuB) [ion binding]; other site 930782008884 K-pathway; other site 930782008885 Putative proton exit pathway; other site 930782008886 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 930782008887 Subunit I/III interface [polypeptide binding]; other site 930782008888 Subunit III/IV interface [polypeptide binding]; other site 930782008889 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 930782008890 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 930782008891 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 930782008892 putative active site [active] 930782008893 putative metal binding site [ion binding]; other site 930782008894 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 930782008895 beta-galactosidase; Region: BGL; TIGR03356 930782008896 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 930782008897 Bacterial SH3 domain; Region: SH3_3; pfam08239 930782008898 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 930782008899 putative active site [active] 930782008900 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 930782008901 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 930782008902 DNA-binding site [nucleotide binding]; DNA binding site 930782008903 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 930782008904 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782008905 active site 930782008906 active pocket/dimerization site; other site 930782008907 phosphorylation site [posttranslational modification] 930782008908 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930782008909 active site 930782008910 phosphorylation site [posttranslational modification] 930782008911 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 930782008912 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 930782008913 hypothetical protein; Provisional; Region: PRK02947 930782008914 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008915 putative active site [active] 930782008916 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 930782008917 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 930782008918 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 930782008919 active site turn [active] 930782008920 phosphorylation site [posttranslational modification] 930782008921 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 930782008922 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 930782008923 HPr interaction site; other site 930782008924 glycerol kinase (GK) interaction site [polypeptide binding]; other site 930782008925 active site 930782008926 phosphorylation site [posttranslational modification] 930782008927 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 930782008928 putative dimer interface [polypeptide binding]; other site 930782008929 catalytic triad [active] 930782008930 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782008931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 930782008932 Walker A/P-loop; other site 930782008933 ATP binding site [chemical binding]; other site 930782008934 Q-loop/lid; other site 930782008935 ABC transporter signature motif; other site 930782008936 Walker B; other site 930782008937 D-loop; other site 930782008938 H-loop/switch region; other site 930782008939 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 930782008940 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 930782008941 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 930782008942 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 930782008943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008944 active site 930782008945 motif I; other site 930782008946 motif II; other site 930782008947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782008948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 930782008949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 930782008950 DNA binding site [nucleotide binding] 930782008951 domain linker motif; other site 930782008952 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 930782008953 dimerization interface [polypeptide binding]; other site 930782008954 putative ligand binding site [chemical binding]; other site 930782008955 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782008956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782008957 nucleotide binding site [chemical binding]; other site 930782008958 Butyrate kinase [Energy production and conversion]; Region: COG3426 930782008959 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 930782008960 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 930782008961 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 930782008962 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 930782008963 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 930782008964 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 930782008965 dimer interface [polypeptide binding]; other site 930782008966 active site 930782008967 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 930782008968 dimer interface [polypeptide binding]; other site 930782008969 active site 930782008970 putrescine carbamoyltransferase; Provisional; Region: PRK02255 930782008971 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 930782008972 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 930782008973 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 930782008974 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 930782008975 agmatine deiminase; Provisional; Region: PRK13551 930782008976 agmatine deiminase; Region: agmatine_aguA; TIGR03380 930782008977 carbamate kinase; Reviewed; Region: PRK12686 930782008978 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 930782008979 putative substrate binding site [chemical binding]; other site 930782008980 nucleotide binding site [chemical binding]; other site 930782008981 nucleotide binding site [chemical binding]; other site 930782008982 homodimer interface [polypeptide binding]; other site 930782008983 agmatine deiminase; Provisional; Region: PRK13551 930782008984 agmatine deiminase; Region: agmatine_aguA; TIGR03380 930782008985 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 930782008986 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 930782008987 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 930782008988 putative active site [active] 930782008989 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 930782008990 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 930782008991 arginine deiminase; Provisional; Region: PRK01388 930782008992 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 930782008993 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930782008994 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930782008995 dimer interface [polypeptide binding]; other site 930782008996 ssDNA binding site [nucleotide binding]; other site 930782008997 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782008998 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 930782008999 Predicted membrane protein [Function unknown]; Region: COG3212 930782009000 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930782009001 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930782009002 putative accessory gene regulator protein; Provisional; Region: PRK01100 930782009003 Staphylococcal AgrD protein; Region: AgrD; cl05477 930782009004 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 930782009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 930782009006 ATP binding site [chemical binding]; other site 930782009007 Mg2+ binding site [ion binding]; other site 930782009008 G-X-G motif; other site 930782009009 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 930782009010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 930782009011 active site 930782009012 phosphorylation site [posttranslational modification] 930782009013 intermolecular recognition site; other site 930782009014 LytTr DNA-binding domain; Region: LytTR; pfam04397 930782009015 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 930782009016 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 930782009017 DHH family; Region: DHH; pfam01368 930782009018 DHHA1 domain; Region: DHHA1; pfam02272 930782009019 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 930782009020 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 930782009021 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 930782009022 replicative DNA helicase; Provisional; Region: PRK05748 930782009023 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 930782009024 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 930782009025 Walker A motif; other site 930782009026 ATP binding site [chemical binding]; other site 930782009027 Walker B motif; other site 930782009028 DNA binding loops [nucleotide binding] 930782009029 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 930782009030 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 930782009031 GDP-binding site [chemical binding]; other site 930782009032 ACT binding site; other site 930782009033 IMP binding site; other site 930782009034 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 930782009035 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 930782009036 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 930782009037 Predicted membrane protein [Function unknown]; Region: COG1511 930782009038 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 930782009039 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 930782009040 Uncharacterized small protein [Function unknown]; Region: COG5417 930782009041 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 930782009042 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 930782009043 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 930782009044 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 930782009045 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930782009046 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 930782009047 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 930782009048 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 930782009049 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 930782009050 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 930782009051 tetramer interface [polypeptide binding]; other site 930782009052 active site 930782009053 Mg2+/Mn2+ binding site [ion binding]; other site 930782009054 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 930782009055 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 930782009056 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 930782009057 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 930782009058 DNA binding site [nucleotide binding] 930782009059 active site 930782009060 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930782009061 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 930782009062 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 930782009063 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 930782009064 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 930782009065 putative ligand binding site [chemical binding]; other site 930782009066 putative NAD binding site [chemical binding]; other site 930782009067 catalytic site [active] 930782009068 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 930782009069 Int/Topo IB signature motif; other site 930782009070 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 930782009071 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 930782009072 putative protein serine/threonine phosphatase; Provisional; Region: PRK14559 930782009073 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930782009074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782009075 non-specific DNA binding site [nucleotide binding]; other site 930782009076 salt bridge; other site 930782009077 sequence-specific DNA binding site [nucleotide binding]; other site 930782009078 Putative zinc-finger; Region: zf-HC2; pfam13490 930782009079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 930782009080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782009081 non-specific DNA binding site [nucleotide binding]; other site 930782009082 salt bridge; other site 930782009083 sequence-specific DNA binding site [nucleotide binding]; other site 930782009084 Prophage antirepressor [Transcription]; Region: COG3617 930782009085 BRO family, N-terminal domain; Region: Bro-N; smart01040 930782009086 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 930782009087 Helix-turn-helix domain; Region: HTH_17; pfam12728 930782009088 Protein gp45 of Bacteriophage A118; Region: Phage-A118_gp45; pfam10653 930782009089 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 930782009090 ERF superfamily; Region: ERF; pfam04404 930782009091 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 930782009092 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 930782009093 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930782009094 cofactor binding site; other site 930782009095 DNA binding site [nucleotide binding] 930782009096 substrate interaction site [chemical binding]; other site 930782009097 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 930782009098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782009099 S-adenosylmethionine binding site [chemical binding]; other site 930782009100 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 930782009101 YopX protein; Region: YopX; cl09859 930782009102 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 930782009103 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 930782009104 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 930782009105 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 930782009106 dimer interface [polypeptide binding]; other site 930782009107 ssDNA binding site [nucleotide binding]; other site 930782009108 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782009109 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 930782009110 Protein of unknown function (DUF2481); Region: DUF2481; pfam10654 930782009111 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930782009112 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 930782009113 Phage terminase large subunit; Region: Terminase_3; pfam04466 930782009114 Terminase-like family; Region: Terminase_6; pfam03237 930782009115 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 930782009116 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 930782009117 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 930782009118 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 930782009119 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 930782009120 Minor capsid protein; Region: Minor_capsid_1; pfam10665 930782009121 Minor capsid protein; Region: Minor_capsid_2; pfam11114 930782009122 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 930782009123 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 930782009124 Phage protein Gp14; Region: Phage_Gp14; pfam10666 930782009125 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 930782009126 tape measure domain; Region: tape_meas_nterm; TIGR02675 930782009127 Phage tail protein; Region: Sipho_tail; pfam05709 930782009128 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 930782009129 putative pectinesterase; Region: PLN02432; cl01911 930782009130 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 930782009131 phage uncharacterized protein, XkdX family; Region: phage_XkdX; TIGR01669 930782009132 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 930782009133 Phage holin; Region: Phage_holin_5; pfam06946 930782009134 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 930782009135 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 930782009136 Abi-like protein; Region: Abi_2; cl01988 930782009137 LXG domain of WXG superfamily; Region: LXG; pfam04740 930782009138 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 930782009139 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 930782009140 DNA binding residues [nucleotide binding] 930782009141 putative dimer interface [polypeptide binding]; other site 930782009142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 930782009143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 930782009144 active site 930782009145 catalytic tetrad [active] 930782009146 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782009147 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782009148 ATP synthase subunit C; Region: ATP-synt_C; cl00466 930782009149 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 930782009150 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 930782009151 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 930782009152 Walker A motif; other site 930782009153 ATP binding site [chemical binding]; other site 930782009154 Walker B motif; other site 930782009155 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930782009156 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 930782009157 core domain interface [polypeptide binding]; other site 930782009158 delta subunit interface [polypeptide binding]; other site 930782009159 epsilon subunit interface [polypeptide binding]; other site 930782009160 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 930782009161 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 930782009162 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 930782009163 alpha subunit interaction interface [polypeptide binding]; other site 930782009164 Walker A motif; other site 930782009165 ATP binding site [chemical binding]; other site 930782009166 Walker B motif; other site 930782009167 inhibitor binding site; inhibition site 930782009168 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 930782009169 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 930782009170 gamma subunit interface [polypeptide binding]; other site 930782009171 epsilon subunit interface [polypeptide binding]; other site 930782009172 LBP interface [polypeptide binding]; other site 930782009173 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782009174 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 930782009175 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 930782009176 active pocket/dimerization site; other site 930782009177 active site 930782009178 phosphorylation site [posttranslational modification] 930782009179 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 930782009180 active site 930782009181 phosphorylation site [posttranslational modification] 930782009182 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 930782009183 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 930782009184 Domain of unknown function (DUF956); Region: DUF956; pfam06115 930782009185 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 930782009186 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 930782009187 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 930782009188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 930782009189 dimerization interface [polypeptide binding]; other site 930782009190 putative DNA binding site [nucleotide binding]; other site 930782009191 Uncharacterized conserved protein [Function unknown]; Region: COG1359 930782009192 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 930782009193 dimer interface [polypeptide binding]; other site 930782009194 FMN binding site [chemical binding]; other site 930782009195 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 930782009196 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 930782009197 active site 930782009198 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 930782009199 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 930782009200 Interdomain contacts; other site 930782009201 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 930782009202 aromatic chitin/cellulose binding site residues [chemical binding]; other site 930782009203 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782009204 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782009205 nucleotide binding site [chemical binding]; other site 930782009206 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782009207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782009208 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930782009209 Walker A/P-loop; other site 930782009210 ATP binding site [chemical binding]; other site 930782009211 Q-loop/lid; other site 930782009212 ABC transporter signature motif; other site 930782009213 Walker B; other site 930782009214 D-loop; other site 930782009215 H-loop/switch region; other site 930782009216 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 930782009217 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 930782009218 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 930782009219 Walker A/P-loop; other site 930782009220 ATP binding site [chemical binding]; other site 930782009221 Q-loop/lid; other site 930782009222 ABC transporter signature motif; other site 930782009223 Walker B; other site 930782009224 D-loop; other site 930782009225 H-loop/switch region; other site 930782009226 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 930782009227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782009228 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 930782009229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 930782009230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 930782009231 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 930782009232 substrate binding pocket [chemical binding]; other site 930782009233 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930782009234 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782009235 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930782009236 ligand binding site [chemical binding]; other site 930782009237 flexible hinge region; other site 930782009238 Domain of unknown function (DUF955); Region: DUF955; pfam06114 930782009239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 930782009240 non-specific DNA binding site [nucleotide binding]; other site 930782009241 salt bridge; other site 930782009242 sequence-specific DNA binding site [nucleotide binding]; other site 930782009243 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 930782009244 Predicted secreted protein [Function unknown]; Region: COG5437 930782009245 Phage-related protein [Function unknown]; Region: COG5412 930782009246 Phage tail protein; Region: Sipho_tail; pfam05709 930782009247 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 930782009248 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 930782009249 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 930782009250 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 930782009251 active site 930782009252 metal binding site [ion binding]; metal-binding site 930782009253 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 930782009254 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 930782009255 putative active site [active] 930782009256 putative metal binding site [ion binding]; other site 930782009257 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 930782009258 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 930782009259 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 930782009260 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 930782009261 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 930782009262 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 930782009263 active site 930782009264 Uncharacterized conserved protein [Function unknown]; Region: COG3592 930782009265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782009266 Coenzyme A binding pocket [chemical binding]; other site 930782009267 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 930782009268 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 930782009269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 930782009270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782009271 dimer interface [polypeptide binding]; other site 930782009272 conserved gate region; other site 930782009273 putative PBP binding loops; other site 930782009274 ABC-ATPase subunit interface; other site 930782009275 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 930782009276 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 930782009277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782009278 dimer interface [polypeptide binding]; other site 930782009279 conserved gate region; other site 930782009280 putative PBP binding loops; other site 930782009281 ABC-ATPase subunit interface; other site 930782009282 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 930782009283 LXG domain of WXG superfamily; Region: LXG; pfam04740 930782009284 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 930782009285 phosphoenolpyruvate synthase; Validated; Region: PRK06464 930782009286 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 930782009287 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 930782009288 peptide binding site [polypeptide binding]; other site 930782009289 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 930782009290 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 930782009291 metal binding site [ion binding]; metal-binding site 930782009292 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 930782009293 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 930782009294 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 930782009295 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 930782009296 ABC-ATPase subunit interface; other site 930782009297 dimer interface [polypeptide binding]; other site 930782009298 putative PBP binding regions; other site 930782009299 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 930782009300 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782009301 ligand binding site [chemical binding]; other site 930782009302 flexible hinge region; other site 930782009303 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 930782009304 DEAD_2; Region: DEAD_2; pfam06733 930782009305 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 930782009306 sugar phosphate phosphatase; Provisional; Region: PRK10513 930782009307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782009308 active site 930782009309 motif I; other site 930782009310 motif II; other site 930782009311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 930782009312 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930782009313 Collagen binding domain; Region: Collagen_bind; pfam05737 930782009314 Cna protein B-type domain; Region: Cna_B; pfam05738 930782009315 Cna protein B-type domain; Region: Cna_B; pfam05738 930782009316 Cna protein B-type domain; Region: Cna_B; pfam05738 930782009317 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 930782009318 Collagen binding domain; Region: Collagen_bind; pfam05737 930782009319 Cna protein B-type domain; Region: Cna_B; pfam05738 930782009320 Cna protein B-type domain; Region: Cna_B; pfam05738 930782009321 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 930782009322 DNA polymerase III subunit delta'; Validated; Region: PRK08058 930782009323 DNA polymerase III subunit delta'; Validated; Region: PRK08485 930782009324 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 930782009325 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 930782009326 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 930782009327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782009328 S-adenosylmethionine binding site [chemical binding]; other site 930782009329 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 930782009330 GIY-YIG motif/motif A; other site 930782009331 putative active site [active] 930782009332 putative metal binding site [ion binding]; other site 930782009333 Predicted methyltransferases [General function prediction only]; Region: COG0313 930782009334 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 930782009335 putative SAM binding site [chemical binding]; other site 930782009336 putative homodimer interface [polypeptide binding]; other site 930782009337 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 930782009338 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 930782009339 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930782009340 Uncharacterized conserved protein [Function unknown]; Region: COG5361 930782009341 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 930782009342 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 930782009343 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 930782009344 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 930782009345 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 930782009346 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 930782009347 active site 930782009348 HIGH motif; other site 930782009349 KMSKS motif; other site 930782009350 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 930782009351 tRNA binding surface [nucleotide binding]; other site 930782009352 anticodon binding site; other site 930782009353 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 930782009354 dimer interface [polypeptide binding]; other site 930782009355 putative tRNA-binding site [nucleotide binding]; other site 930782009356 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 930782009357 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 930782009358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 930782009359 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 930782009360 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 930782009361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782009362 dimer interface [polypeptide binding]; other site 930782009363 conserved gate region; other site 930782009364 putative PBP binding loops; other site 930782009365 ABC-ATPase subunit interface; other site 930782009366 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 930782009367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 930782009368 dimer interface [polypeptide binding]; other site 930782009369 conserved gate region; other site 930782009370 putative PBP binding loops; other site 930782009371 ABC-ATPase subunit interface; other site 930782009372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 930782009373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 930782009374 alpha-glucosidase; Provisional; Region: PRK10426 930782009375 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930782009376 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 930782009377 active site 930782009378 catalytic site [active] 930782009379 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 930782009380 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 930782009381 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 930782009382 trimer interface [polypeptide binding]; other site 930782009383 active site 930782009384 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 930782009385 catalytic site [active] 930782009386 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 930782009387 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 930782009388 Ca binding site [ion binding]; other site 930782009389 active site 930782009390 catalytic site [active] 930782009391 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 930782009392 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 930782009393 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 930782009394 active site 930782009395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 930782009396 Domain of unknown function (DUF348); Region: DUF348; pfam03990 930782009397 Domain of unknown function (DUF348); Region: DUF348; pfam03990 930782009398 G5 domain; Region: G5; pfam07501 930782009399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 930782009400 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 930782009401 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 930782009402 putative active site [active] 930782009403 putative metal binding site [ion binding]; other site 930782009404 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 930782009405 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 930782009406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 930782009407 S-adenosylmethionine binding site [chemical binding]; other site 930782009408 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 930782009409 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 930782009410 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 930782009411 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 930782009412 putative active site [active] 930782009413 YdjC motif; other site 930782009414 Mg binding site [ion binding]; other site 930782009415 putative homodimer interface [polypeptide binding]; other site 930782009416 pur operon repressor; Provisional; Region: PRK09213 930782009417 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 930782009418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782009419 active site 930782009420 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 930782009421 HlyD family secretion protein; Region: HlyD_3; pfam13437 930782009422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 930782009423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 930782009424 Walker A/P-loop; other site 930782009425 ATP binding site [chemical binding]; other site 930782009426 Q-loop/lid; other site 930782009427 ABC transporter signature motif; other site 930782009428 Walker B; other site 930782009429 D-loop; other site 930782009430 H-loop/switch region; other site 930782009431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 930782009432 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 930782009433 FtsX-like permease family; Region: FtsX; pfam02687 930782009434 regulatory protein SpoVG; Reviewed; Region: PRK13259 930782009435 regulatory protein SpoVG; Reviewed; Region: PRK13259 930782009436 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 930782009437 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 930782009438 Substrate binding site; other site 930782009439 Mg++ binding site; other site 930782009440 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 930782009441 active site 930782009442 substrate binding site [chemical binding]; other site 930782009443 CoA binding site [chemical binding]; other site 930782009444 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 930782009445 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 930782009446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782009447 active site 930782009448 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 930782009449 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 930782009450 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 930782009451 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 930782009452 active site 930782009453 catalytic site [active] 930782009454 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 930782009455 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 930782009456 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 930782009457 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 930782009458 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 930782009459 active site 930782009460 Zn binding site [ion binding]; other site 930782009461 ActA Protein; Region: ActA; pfam05058 930782009462 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 930782009463 Zn binding site [ion binding]; other site 930782009464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 930782009465 hypothetical protein; Provisional; Region: PRK01119 930782009466 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 930782009467 A new structural DNA glycosylase; Region: AlkD_like; cd06561 930782009468 active site 930782009469 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 930782009470 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 930782009471 tetramer (dimer of dimers) interface [polypeptide binding]; other site 930782009472 NAD binding site [chemical binding]; other site 930782009473 dimer interface [polypeptide binding]; other site 930782009474 substrate binding site [chemical binding]; other site 930782009475 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 930782009476 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 930782009477 5S rRNA interface [nucleotide binding]; other site 930782009478 CTC domain interface [polypeptide binding]; other site 930782009479 L16 interface [polypeptide binding]; other site 930782009480 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 930782009481 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 930782009482 Coenzyme A binding pocket [chemical binding]; other site 930782009483 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 930782009484 putative active site [active] 930782009485 catalytic residue [active] 930782009486 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 930782009487 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 930782009488 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 930782009489 ATP binding site [chemical binding]; other site 930782009490 putative Mg++ binding site [ion binding]; other site 930782009491 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 930782009492 nucleotide binding region [chemical binding]; other site 930782009493 ATP-binding site [chemical binding]; other site 930782009494 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 930782009495 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 930782009496 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 930782009497 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 930782009498 RNA binding surface [nucleotide binding]; other site 930782009499 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 930782009500 Septum formation initiator; Region: DivIC; pfam04977 930782009501 hypothetical protein; Provisional; Region: PRK08582 930782009502 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 930782009503 RNA binding site [nucleotide binding]; other site 930782009504 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 930782009505 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 930782009506 Ligand Binding Site [chemical binding]; other site 930782009507 TilS substrate C-terminal domain; Region: TilS_C; smart00977 930782009508 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 930782009509 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 930782009510 active site 930782009511 FtsH Extracellular; Region: FtsH_ext; pfam06480 930782009512 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 930782009513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 930782009514 Walker A motif; other site 930782009515 ATP binding site [chemical binding]; other site 930782009516 Walker B motif; other site 930782009517 arginine finger; other site 930782009518 Peptidase family M41; Region: Peptidase_M41; pfam01434 930782009519 pantothenate kinase; Reviewed; Region: PRK13318 930782009520 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 930782009521 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 930782009522 dimerization interface [polypeptide binding]; other site 930782009523 domain crossover interface; other site 930782009524 redox-dependent activation switch; other site 930782009525 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 930782009526 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 930782009527 dimer interface [polypeptide binding]; other site 930782009528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 930782009529 catalytic residue [active] 930782009530 dihydropteroate synthase; Region: DHPS; TIGR01496 930782009531 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 930782009532 substrate binding pocket [chemical binding]; other site 930782009533 dimer interface [polypeptide binding]; other site 930782009534 inhibitor binding site; inhibition site 930782009535 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 930782009536 homooctamer interface [polypeptide binding]; other site 930782009537 active site 930782009538 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 930782009539 catalytic center binding site [active] 930782009540 ATP binding site [chemical binding]; other site 930782009541 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 930782009542 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 930782009543 FMN binding site [chemical binding]; other site 930782009544 active site 930782009545 catalytic residues [active] 930782009546 substrate binding site [chemical binding]; other site 930782009547 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 930782009548 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 930782009549 dimer interface [polypeptide binding]; other site 930782009550 putative anticodon binding site; other site 930782009551 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 930782009552 motif 1; other site 930782009553 active site 930782009554 motif 2; other site 930782009555 motif 3; other site