-- dump date 20140619_133608 -- class Genbank::misc_feature -- table misc_feature_note -- id note 882094000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 882094000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 882094000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094000004 Walker A motif; other site 882094000005 ATP binding site [chemical binding]; other site 882094000006 Walker B motif; other site 882094000007 arginine finger; other site 882094000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 882094000009 DnaA box-binding interface [nucleotide binding]; other site 882094000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 882094000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 882094000012 putative DNA binding surface [nucleotide binding]; other site 882094000013 dimer interface [polypeptide binding]; other site 882094000014 beta-clamp/clamp loader binding surface; other site 882094000015 beta-clamp/translesion DNA polymerase binding surface; other site 882094000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882094000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 882094000018 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 882094000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 882094000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 882094000021 Walker A/P-loop; other site 882094000022 ATP binding site [chemical binding]; other site 882094000023 Q-loop/lid; other site 882094000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094000025 ABC transporter signature motif; other site 882094000026 Walker B; other site 882094000027 D-loop; other site 882094000028 H-loop/switch region; other site 882094000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 882094000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094000031 Mg2+ binding site [ion binding]; other site 882094000032 G-X-G motif; other site 882094000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882094000034 anchoring element; other site 882094000035 dimer interface [polypeptide binding]; other site 882094000036 ATP binding site [chemical binding]; other site 882094000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882094000038 active site 882094000039 putative metal-binding site [ion binding]; other site 882094000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882094000041 DNA gyrase subunit A; Validated; Region: PRK05560 882094000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882094000043 CAP-like domain; other site 882094000044 active site 882094000045 primary dimer interface [polypeptide binding]; other site 882094000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094000051 cardiolipin synthetase; Reviewed; Region: PRK12452 882094000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882094000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882094000054 putative active site [active] 882094000055 catalytic site [active] 882094000056 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882094000057 putative active site [active] 882094000058 catalytic site [active] 882094000059 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882094000060 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094000061 Coenzyme A binding pocket [chemical binding]; other site 882094000062 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 882094000063 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882094000064 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882094000065 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 882094000066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882094000067 SH3-like domain; Region: SH3_8; pfam13457 882094000068 SH3-like domain; Region: SH3_8; pfam13457 882094000069 SH3-like domain; Region: SH3_8; pfam13457 882094000070 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 882094000071 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 882094000072 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 882094000073 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 882094000074 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 882094000075 D-pathway; other site 882094000076 Putative ubiquinol binding site [chemical binding]; other site 882094000077 Low-spin heme (heme b) binding site [chemical binding]; other site 882094000078 Putative water exit pathway; other site 882094000079 Binuclear center (heme o3/CuB) [ion binding]; other site 882094000080 K-pathway; other site 882094000081 Putative proton exit pathway; other site 882094000082 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 882094000083 Subunit I/III interface [polypeptide binding]; other site 882094000084 Subunit III/IV interface [polypeptide binding]; other site 882094000085 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 882094000086 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882094000087 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 882094000088 putative active site [active] 882094000089 putative metal binding site [ion binding]; other site 882094000090 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882094000091 beta-galactosidase; Region: BGL; TIGR03356 882094000092 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882094000093 Bacterial SH3 domain; Region: SH3_3; pfam08239 882094000094 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882094000095 putative active site [active] 882094000096 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094000097 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094000098 DNA-binding site [nucleotide binding]; DNA binding site 882094000099 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882094000100 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094000101 active site 882094000102 active pocket/dimerization site; other site 882094000103 phosphorylation site [posttranslational modification] 882094000104 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882094000105 active site 882094000106 phosphorylation site [posttranslational modification] 882094000107 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 882094000108 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 882094000109 hypothetical protein; Provisional; Region: PRK02947 882094000110 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094000111 putative active site [active] 882094000112 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882094000113 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 882094000114 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882094000115 active site turn [active] 882094000116 phosphorylation site [posttranslational modification] 882094000117 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882094000118 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882094000119 HPr interaction site; other site 882094000120 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882094000121 active site 882094000122 phosphorylation site [posttranslational modification] 882094000123 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882094000124 putative dimer interface [polypeptide binding]; other site 882094000125 catalytic triad [active] 882094000126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094000127 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 882094000128 Walker A/P-loop; other site 882094000129 ATP binding site [chemical binding]; other site 882094000130 Q-loop/lid; other site 882094000131 ABC transporter signature motif; other site 882094000132 Walker B; other site 882094000133 D-loop; other site 882094000134 H-loop/switch region; other site 882094000135 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 882094000136 Protein of unknown function (DUF2712); Region: DUF2712; pfam10916 882094000137 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094000138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000139 active site 882094000140 motif I; other site 882094000141 motif II; other site 882094000142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000143 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094000144 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094000145 DNA binding site [nucleotide binding] 882094000146 domain linker motif; other site 882094000147 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 882094000148 dimerization interface [polypeptide binding]; other site 882094000149 putative ligand binding site [chemical binding]; other site 882094000150 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094000151 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094000152 nucleotide binding site [chemical binding]; other site 882094000153 Butyrate kinase [Energy production and conversion]; Region: COG3426 882094000154 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 882094000155 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 882094000156 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094000157 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094000158 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882094000159 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882094000160 dimer interface [polypeptide binding]; other site 882094000161 active site 882094000162 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882094000163 dimer interface [polypeptide binding]; other site 882094000164 active site 882094000165 putrescine carbamoyltransferase; Provisional; Region: PRK02255 882094000166 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882094000167 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882094000168 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 882094000169 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 882094000170 agmatine deiminase; Provisional; Region: PRK13551 882094000171 agmatine deiminase; Region: agmatine_aguA; TIGR03380 882094000172 carbamate kinase; Reviewed; Region: PRK12686 882094000173 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 882094000174 putative substrate binding site [chemical binding]; other site 882094000175 nucleotide binding site [chemical binding]; other site 882094000176 nucleotide binding site [chemical binding]; other site 882094000177 homodimer interface [polypeptide binding]; other site 882094000178 agmatine deiminase; Provisional; Region: PRK13551 882094000179 agmatine deiminase; Region: agmatine_aguA; TIGR03380 882094000180 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094000181 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094000182 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094000183 putative active site [active] 882094000184 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 882094000185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882094000186 arginine deiminase; Provisional; Region: PRK01388 882094000187 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 882094000188 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882094000189 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882094000190 dimer interface [polypeptide binding]; other site 882094000191 ssDNA binding site [nucleotide binding]; other site 882094000192 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094000193 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 882094000194 Predicted membrane protein [Function unknown]; Region: COG3212 882094000195 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882094000196 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882094000197 putative accessory gene regulator protein; Provisional; Region: PRK01100 882094000198 Staphylococcal AgrD protein; Region: AgrD; cl05477 882094000199 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882094000200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094000201 ATP binding site [chemical binding]; other site 882094000202 Mg2+ binding site [ion binding]; other site 882094000203 G-X-G motif; other site 882094000204 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882094000205 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094000206 active site 882094000207 phosphorylation site [posttranslational modification] 882094000208 intermolecular recognition site; other site 882094000209 LytTr DNA-binding domain; Region: LytTR; pfam04397 882094000210 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 882094000211 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 882094000212 DHH family; Region: DHH; pfam01368 882094000213 DHHA1 domain; Region: DHHA1; pfam02272 882094000214 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 882094000215 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 882094000216 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 882094000217 replicative DNA helicase; Provisional; Region: PRK05748 882094000218 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 882094000219 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 882094000220 Walker A motif; other site 882094000221 ATP binding site [chemical binding]; other site 882094000222 Walker B motif; other site 882094000223 DNA binding loops [nucleotide binding] 882094000224 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 882094000225 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 882094000226 GDP-binding site [chemical binding]; other site 882094000227 ACT binding site; other site 882094000228 IMP binding site; other site 882094000229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 882094000230 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882094000231 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 882094000232 Predicted membrane protein [Function unknown]; Region: COG1511 882094000233 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 882094000234 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 882094000235 Uncharacterized small protein [Function unknown]; Region: COG5417 882094000236 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 882094000237 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 882094000238 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 882094000239 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 882094000240 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882094000241 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882094000242 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 882094000243 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 882094000244 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 882094000245 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 882094000246 tetramer interface [polypeptide binding]; other site 882094000247 active site 882094000248 Mg2+/Mn2+ binding site [ion binding]; other site 882094000249 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882094000250 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882094000251 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882094000252 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882094000253 DNA binding site [nucleotide binding] 882094000254 active site 882094000255 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882094000256 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 882094000257 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 882094000258 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 882094000259 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 882094000260 putative ligand binding site [chemical binding]; other site 882094000261 putative NAD binding site [chemical binding]; other site 882094000262 catalytic site [active] 882094000263 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094000264 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094000265 DNA binding residues [nucleotide binding] 882094000266 putative dimer interface [polypeptide binding]; other site 882094000267 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094000268 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094000269 active site 882094000270 catalytic tetrad [active] 882094000271 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094000272 ATP synthase subunit C; Region: ATP-synt_C; cl00466 882094000273 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882094000274 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 882094000275 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882094000276 Walker A motif; other site 882094000277 ATP binding site [chemical binding]; other site 882094000278 Walker B motif; other site 882094000279 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882094000280 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882094000281 core domain interface [polypeptide binding]; other site 882094000282 delta subunit interface [polypeptide binding]; other site 882094000283 epsilon subunit interface [polypeptide binding]; other site 882094000284 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 882094000285 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882094000286 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882094000287 alpha subunit interaction interface [polypeptide binding]; other site 882094000288 Walker A motif; other site 882094000289 ATP binding site [chemical binding]; other site 882094000290 Walker B motif; other site 882094000291 inhibitor binding site; inhibition site 882094000292 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882094000293 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 882094000294 gamma subunit interface [polypeptide binding]; other site 882094000295 epsilon subunit interface [polypeptide binding]; other site 882094000296 LBP interface [polypeptide binding]; other site 882094000297 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000298 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 882094000299 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094000300 active pocket/dimerization site; other site 882094000301 active site 882094000302 phosphorylation site [posttranslational modification] 882094000303 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882094000304 active site 882094000305 phosphorylation site [posttranslational modification] 882094000306 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882094000307 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882094000308 Domain of unknown function (DUF956); Region: DUF956; pfam06115 882094000309 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 882094000310 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882094000311 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 882094000312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094000313 dimerization interface [polypeptide binding]; other site 882094000314 putative DNA binding site [nucleotide binding]; other site 882094000315 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882094000316 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 882094000317 dimer interface [polypeptide binding]; other site 882094000318 FMN binding site [chemical binding]; other site 882094000319 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 882094000320 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 882094000321 active site 882094000322 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882094000323 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882094000324 Interdomain contacts; other site 882094000325 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882094000326 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882094000327 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094000328 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094000329 nucleotide binding site [chemical binding]; other site 882094000330 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094000331 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094000332 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882094000333 Walker A/P-loop; other site 882094000334 ATP binding site [chemical binding]; other site 882094000335 Q-loop/lid; other site 882094000336 ABC transporter signature motif; other site 882094000337 Walker B; other site 882094000338 D-loop; other site 882094000339 H-loop/switch region; other site 882094000340 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094000341 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094000342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094000343 Walker A/P-loop; other site 882094000344 ATP binding site [chemical binding]; other site 882094000345 Q-loop/lid; other site 882094000346 ABC transporter signature motif; other site 882094000347 Walker B; other site 882094000348 D-loop; other site 882094000349 H-loop/switch region; other site 882094000350 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 882094000351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094000352 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094000353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094000354 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882094000355 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882094000356 substrate binding pocket [chemical binding]; other site 882094000357 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882094000358 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000359 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882094000360 ligand binding site [chemical binding]; other site 882094000361 flexible hinge region; other site 882094000362 Domain of unknown function (DUF955); Region: DUF955; pfam06114 882094000363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094000364 non-specific DNA binding site [nucleotide binding]; other site 882094000365 salt bridge; other site 882094000366 sequence-specific DNA binding site [nucleotide binding]; other site 882094000367 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 882094000368 Predicted secreted protein [Function unknown]; Region: COG5437 882094000369 Phage-related protein [Function unknown]; Region: COG5412 882094000370 Phage tail protein; Region: Sipho_tail; pfam05709 882094000371 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 882094000372 Phage-related holin (Lysis protein) [General function prediction only]; Region: COG4824 882094000373 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882094000374 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882094000375 active site 882094000376 metal binding site [ion binding]; metal-binding site 882094000377 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882094000378 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 882094000379 putative active site [active] 882094000380 putative metal binding site [ion binding]; other site 882094000381 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882094000382 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882094000383 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07107 882094000384 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 882094000385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 882094000386 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882094000387 active site 882094000388 Uncharacterized conserved protein [Function unknown]; Region: COG3592 882094000389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094000390 Coenzyme A binding pocket [chemical binding]; other site 882094000391 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 882094000392 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 882094000393 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882094000394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000395 dimer interface [polypeptide binding]; other site 882094000396 conserved gate region; other site 882094000397 putative PBP binding loops; other site 882094000398 ABC-ATPase subunit interface; other site 882094000399 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882094000400 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 882094000401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000402 dimer interface [polypeptide binding]; other site 882094000403 conserved gate region; other site 882094000404 putative PBP binding loops; other site 882094000405 ABC-ATPase subunit interface; other site 882094000406 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 882094000407 LXG domain of WXG superfamily; Region: LXG; pfam04740 882094000408 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 882094000409 phosphoenolpyruvate synthase; Validated; Region: PRK06464 882094000410 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882094000411 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882094000412 peptide binding site [polypeptide binding]; other site 882094000413 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882094000414 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882094000415 metal binding site [ion binding]; metal-binding site 882094000416 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 882094000417 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882094000418 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882094000419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094000420 ABC-ATPase subunit interface; other site 882094000421 dimer interface [polypeptide binding]; other site 882094000422 putative PBP binding regions; other site 882094000423 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882094000424 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000425 ligand binding site [chemical binding]; other site 882094000426 flexible hinge region; other site 882094000427 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 882094000428 DEAD_2; Region: DEAD_2; pfam06733 882094000429 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882094000430 sugar phosphate phosphatase; Provisional; Region: PRK10513 882094000431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000432 active site 882094000433 motif I; other site 882094000434 motif II; other site 882094000435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000436 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882094000437 Collagen binding domain; Region: Collagen_bind; pfam05737 882094000438 Cna protein B-type domain; Region: Cna_B; pfam05738 882094000439 Cna protein B-type domain; Region: Cna_B; pfam05738 882094000440 Cna protein B-type domain; Region: Cna_B; pfam05738 882094000441 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882094000442 Collagen binding domain; Region: Collagen_bind; pfam05737 882094000443 Cna protein B-type domain; Region: Cna_B; pfam05738 882094000444 Cna protein B-type domain; Region: Cna_B; pfam05738 882094000445 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094000446 DNA polymerase III subunit delta'; Validated; Region: PRK08058 882094000447 DNA polymerase III subunit delta'; Validated; Region: PRK08485 882094000448 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 882094000449 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 882094000450 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 882094000451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094000452 S-adenosylmethionine binding site [chemical binding]; other site 882094000453 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 882094000454 GIY-YIG motif/motif A; other site 882094000455 putative active site [active] 882094000456 putative metal binding site [ion binding]; other site 882094000457 Predicted methyltransferases [General function prediction only]; Region: COG0313 882094000458 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 882094000459 putative SAM binding site [chemical binding]; other site 882094000460 putative homodimer interface [polypeptide binding]; other site 882094000461 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 882094000462 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 882094000463 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882094000464 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882094000465 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882094000466 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 882094000467 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094000468 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882094000469 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 882094000470 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 882094000471 active site 882094000472 HIGH motif; other site 882094000473 KMSKS motif; other site 882094000474 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 882094000475 tRNA binding surface [nucleotide binding]; other site 882094000476 anticodon binding site; other site 882094000477 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 882094000478 dimer interface [polypeptide binding]; other site 882094000479 putative tRNA-binding site [nucleotide binding]; other site 882094000480 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 882094000481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094000482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094000483 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882094000484 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882094000485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000486 dimer interface [polypeptide binding]; other site 882094000487 conserved gate region; other site 882094000488 putative PBP binding loops; other site 882094000489 ABC-ATPase subunit interface; other site 882094000490 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094000491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000492 dimer interface [polypeptide binding]; other site 882094000493 conserved gate region; other site 882094000494 putative PBP binding loops; other site 882094000495 ABC-ATPase subunit interface; other site 882094000496 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882094000497 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094000498 alpha-glucosidase; Provisional; Region: PRK10426 882094000499 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882094000500 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882094000501 active site 882094000502 catalytic site [active] 882094000503 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882094000504 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882094000505 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 882094000506 trimer interface [polypeptide binding]; other site 882094000507 active site 882094000508 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 882094000509 catalytic site [active] 882094000510 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882094000511 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882094000512 Ca binding site [ion binding]; other site 882094000513 active site 882094000514 catalytic site [active] 882094000515 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 882094000516 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 882094000517 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 882094000518 active site 882094000519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 882094000520 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882094000521 Domain of unknown function (DUF348); Region: DUF348; pfam03990 882094000522 G5 domain; Region: G5; pfam07501 882094000523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882094000524 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 882094000525 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 882094000526 putative active site [active] 882094000527 putative metal binding site [ion binding]; other site 882094000528 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 882094000529 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 882094000530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094000531 S-adenosylmethionine binding site [chemical binding]; other site 882094000532 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 882094000533 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 882094000534 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882094000535 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 882094000536 putative active site [active] 882094000537 YdjC motif; other site 882094000538 Mg binding site [ion binding]; other site 882094000539 putative homodimer interface [polypeptide binding]; other site 882094000540 pur operon repressor; Provisional; Region: PRK09213 882094000541 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 882094000542 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094000543 active site 882094000544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 882094000545 HlyD family secretion protein; Region: HlyD_3; pfam13437 882094000546 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094000547 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094000548 Walker A/P-loop; other site 882094000549 ATP binding site [chemical binding]; other site 882094000550 Q-loop/lid; other site 882094000551 ABC transporter signature motif; other site 882094000552 Walker B; other site 882094000553 D-loop; other site 882094000554 H-loop/switch region; other site 882094000555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094000556 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882094000557 FtsX-like permease family; Region: FtsX; pfam02687 882094000558 regulatory protein SpoVG; Reviewed; Region: PRK13259 882094000559 regulatory protein SpoVG; Reviewed; Region: PRK13259 882094000560 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 882094000561 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 882094000562 Substrate binding site; other site 882094000563 Mg++ binding site; other site 882094000564 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 882094000565 active site 882094000566 substrate binding site [chemical binding]; other site 882094000567 CoA binding site [chemical binding]; other site 882094000568 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882094000569 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882094000570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094000571 active site 882094000572 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000573 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094000574 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094000575 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 882094000576 active site 882094000577 catalytic site [active] 882094000578 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 882094000579 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 882094000580 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 882094000581 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882094000582 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 882094000583 active site 882094000584 Zn binding site [ion binding]; other site 882094000585 ActA Protein; Region: ActA; pfam05058 882094000586 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 882094000587 Zn binding site [ion binding]; other site 882094000588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 882094000589 hypothetical protein; Provisional; Region: PRK01119 882094000590 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882094000591 A new structural DNA glycosylase; Region: AlkD_like; cd06561 882094000592 active site 882094000593 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 882094000594 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882094000595 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094000596 NAD binding site [chemical binding]; other site 882094000597 dimer interface [polypeptide binding]; other site 882094000598 substrate binding site [chemical binding]; other site 882094000599 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 882094000600 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 882094000601 5S rRNA interface [nucleotide binding]; other site 882094000602 CTC domain interface [polypeptide binding]; other site 882094000603 L16 interface [polypeptide binding]; other site 882094000604 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094000605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094000606 Coenzyme A binding pocket [chemical binding]; other site 882094000607 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 882094000608 putative active site [active] 882094000609 catalytic residue [active] 882094000610 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 882094000611 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 882094000612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094000613 ATP binding site [chemical binding]; other site 882094000614 putative Mg++ binding site [ion binding]; other site 882094000615 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094000616 nucleotide binding region [chemical binding]; other site 882094000617 ATP-binding site [chemical binding]; other site 882094000618 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 882094000619 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882094000620 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882094000621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094000622 RNA binding surface [nucleotide binding]; other site 882094000623 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 882094000624 Septum formation initiator; Region: DivIC; pfam04977 882094000625 hypothetical protein; Provisional; Region: PRK08582 882094000626 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882094000627 RNA binding site [nucleotide binding]; other site 882094000628 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 882094000629 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 882094000630 Ligand Binding Site [chemical binding]; other site 882094000631 TilS substrate C-terminal domain; Region: TilS_C; smart00977 882094000632 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882094000633 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094000634 active site 882094000635 FtsH Extracellular; Region: FtsH_ext; pfam06480 882094000636 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 882094000637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094000638 Walker A motif; other site 882094000639 ATP binding site [chemical binding]; other site 882094000640 Walker B motif; other site 882094000641 arginine finger; other site 882094000642 Peptidase family M41; Region: Peptidase_M41; pfam01434 882094000643 pantothenate kinase; Reviewed; Region: PRK13318 882094000644 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 882094000645 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 882094000646 dimerization interface [polypeptide binding]; other site 882094000647 domain crossover interface; other site 882094000648 redox-dependent activation switch; other site 882094000649 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 882094000650 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 882094000651 dimer interface [polypeptide binding]; other site 882094000652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094000653 catalytic residue [active] 882094000654 dihydropteroate synthase; Region: DHPS; TIGR01496 882094000655 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 882094000656 substrate binding pocket [chemical binding]; other site 882094000657 dimer interface [polypeptide binding]; other site 882094000658 inhibitor binding site; inhibition site 882094000659 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 882094000660 homooctamer interface [polypeptide binding]; other site 882094000661 active site 882094000662 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 882094000663 catalytic center binding site [active] 882094000664 ATP binding site [chemical binding]; other site 882094000665 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 882094000666 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 882094000667 FMN binding site [chemical binding]; other site 882094000668 active site 882094000669 catalytic residues [active] 882094000670 substrate binding site [chemical binding]; other site 882094000671 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 882094000672 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 882094000673 dimer interface [polypeptide binding]; other site 882094000674 putative anticodon binding site; other site 882094000675 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 882094000676 motif 1; other site 882094000677 active site 882094000678 motif 2; other site 882094000679 motif 3; other site 882094000680 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 882094000681 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 882094000682 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 882094000683 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 882094000684 ADP binding site [chemical binding]; other site 882094000685 phosphagen binding site; other site 882094000686 substrate specificity loop; other site 882094000687 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 882094000688 Clp amino terminal domain; Region: Clp_N; pfam02861 882094000689 Clp amino terminal domain; Region: Clp_N; pfam02861 882094000690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094000691 Walker A motif; other site 882094000692 ATP binding site [chemical binding]; other site 882094000693 Walker B motif; other site 882094000694 arginine finger; other site 882094000695 UvrB/uvrC motif; Region: UVR; pfam02151 882094000696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094000697 Walker A motif; other site 882094000698 ATP binding site [chemical binding]; other site 882094000699 Walker B motif; other site 882094000700 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882094000701 DNA repair protein RadA; Provisional; Region: PRK11823 882094000702 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 882094000703 Walker A motif/ATP binding site; other site 882094000704 ATP binding site [chemical binding]; other site 882094000705 Walker B motif; other site 882094000706 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 882094000707 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 882094000708 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 882094000709 putative active site [active] 882094000710 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882094000711 substrate binding site; other site 882094000712 dimer interface; other site 882094000713 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 882094000714 homotrimer interaction site [polypeptide binding]; other site 882094000715 zinc binding site [ion binding]; other site 882094000716 CDP-binding sites; other site 882094000717 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 882094000718 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882094000719 HIGH motif; other site 882094000720 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 882094000721 active site 882094000722 KMSKS motif; other site 882094000723 serine O-acetyltransferase; Region: cysE; TIGR01172 882094000724 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 882094000725 trimer interface [polypeptide binding]; other site 882094000726 active site 882094000727 substrate binding site [chemical binding]; other site 882094000728 CoA binding site [chemical binding]; other site 882094000729 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 882094000730 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882094000731 active site 882094000732 HIGH motif; other site 882094000733 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 882094000734 KMSKS motif; other site 882094000735 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 882094000736 tRNA binding surface [nucleotide binding]; other site 882094000737 anticodon binding site; other site 882094000738 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882094000739 active site 882094000740 metal binding site [ion binding]; metal-binding site 882094000741 dimerization interface [polypeptide binding]; other site 882094000742 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882094000743 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 882094000744 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882094000745 Predicted RNA-binding protein containing a PIN domain [General function prediction only]; Region: COG3688 882094000746 RNA polymerase factor sigma-70; Validated; Region: PRK08295 882094000747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882094000748 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 882094000749 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 882094000750 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 882094000751 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 882094000752 putative homodimer interface [polypeptide binding]; other site 882094000753 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 882094000754 heterodimer interface [polypeptide binding]; other site 882094000755 homodimer interface [polypeptide binding]; other site 882094000756 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 882094000757 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 882094000758 23S rRNA interface [nucleotide binding]; other site 882094000759 L7/L12 interface [polypeptide binding]; other site 882094000760 putative thiostrepton binding site; other site 882094000761 L25 interface [polypeptide binding]; other site 882094000762 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 882094000763 mRNA/rRNA interface [nucleotide binding]; other site 882094000764 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 882094000765 23S rRNA interface [nucleotide binding]; other site 882094000766 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 882094000767 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 882094000768 core dimer interface [polypeptide binding]; other site 882094000769 peripheral dimer interface [polypeptide binding]; other site 882094000770 L10 interface [polypeptide binding]; other site 882094000771 L11 interface [polypeptide binding]; other site 882094000772 putative EF-Tu interaction site [polypeptide binding]; other site 882094000773 putative EF-G interaction site [polypeptide binding]; other site 882094000774 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882094000775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094000776 S-adenosylmethionine binding site [chemical binding]; other site 882094000777 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 882094000778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094000779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094000780 DNA binding site [nucleotide binding] 882094000781 domain linker motif; other site 882094000782 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882094000783 putative dimerization interface [polypeptide binding]; other site 882094000784 putative ligand binding site [chemical binding]; other site 882094000785 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 882094000786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094000787 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882094000788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000789 dimer interface [polypeptide binding]; other site 882094000790 conserved gate region; other site 882094000791 putative PBP binding loops; other site 882094000792 ABC-ATPase subunit interface; other site 882094000793 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000795 dimer interface [polypeptide binding]; other site 882094000796 conserved gate region; other site 882094000797 putative PBP binding loops; other site 882094000798 ABC-ATPase subunit interface; other site 882094000799 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882094000800 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882094000801 Ca binding site [ion binding]; other site 882094000802 active site 882094000803 catalytic site [active] 882094000804 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 882094000805 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882094000806 active site 882094000807 homodimer interface [polypeptide binding]; other site 882094000808 catalytic site [active] 882094000809 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 882094000810 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882094000811 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882094000812 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 882094000813 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 882094000814 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 882094000815 RPB10 interaction site [polypeptide binding]; other site 882094000816 RPB1 interaction site [polypeptide binding]; other site 882094000817 RPB11 interaction site [polypeptide binding]; other site 882094000818 RPB3 interaction site [polypeptide binding]; other site 882094000819 RPB12 interaction site [polypeptide binding]; other site 882094000820 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 882094000821 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 882094000822 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 882094000823 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 882094000824 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 882094000825 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882094000826 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 882094000827 G-loop; other site 882094000828 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 882094000829 DNA binding site [nucleotide binding] 882094000830 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 882094000831 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 882094000832 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000833 active site 882094000834 motif I; other site 882094000835 motif II; other site 882094000836 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094000837 beta-galactosidase; Region: BGL; TIGR03356 882094000838 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882094000839 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 882094000840 Walker A/P-loop; other site 882094000841 ATP binding site [chemical binding]; other site 882094000842 Q-loop/lid; other site 882094000843 ABC transporter signature motif; other site 882094000844 Walker B; other site 882094000845 D-loop; other site 882094000846 H-loop/switch region; other site 882094000847 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882094000848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 882094000849 Walker A/P-loop; other site 882094000850 ATP binding site [chemical binding]; other site 882094000851 Q-loop/lid; other site 882094000852 ABC transporter signature motif; other site 882094000853 Walker B; other site 882094000854 D-loop; other site 882094000855 H-loop/switch region; other site 882094000856 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094000857 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094000858 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094000859 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000860 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000861 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000862 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000863 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000864 LRR adjacent; Region: LRR_adjacent; pfam08191 882094000865 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094000866 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094000867 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094000868 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094000869 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000870 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000871 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000872 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000873 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000874 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000875 LRR adjacent; Region: LRR_adjacent; pfam08191 882094000876 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094000877 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094000878 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094000879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000880 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000881 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094000882 Leucine-rich repeats; other site 882094000883 Substrate binding site [chemical binding]; other site 882094000884 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000886 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000887 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000888 LRR adjacent; Region: LRR_adjacent; pfam08191 882094000889 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094000890 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094000891 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 882094000892 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 882094000893 metal binding site [ion binding]; metal-binding site 882094000894 dimer interface [polypeptide binding]; other site 882094000895 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094000896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094000897 putative Zn2+ binding site [ion binding]; other site 882094000898 putative DNA binding site [nucleotide binding]; other site 882094000899 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882094000900 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094000901 Zn binding site [ion binding]; other site 882094000902 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882094000903 Zn binding site [ion binding]; other site 882094000904 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094000905 catalytic core [active] 882094000906 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 882094000907 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882094000908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882094000909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000910 dimer interface [polypeptide binding]; other site 882094000911 conserved gate region; other site 882094000912 ABC-ATPase subunit interface; other site 882094000913 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094000914 Substrate binding site [chemical binding]; other site 882094000915 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000916 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000917 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000918 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000919 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094000920 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882094000921 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094000922 beta-galactosidase; Region: BGL; TIGR03356 882094000923 sugar phosphate phosphatase; Provisional; Region: PRK10513 882094000924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000925 active site 882094000926 motif I; other site 882094000927 motif II; other site 882094000928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094000930 Coenzyme A binding pocket [chemical binding]; other site 882094000931 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000932 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 882094000933 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882094000934 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882094000935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000936 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 882094000937 active site 882094000938 motif I; other site 882094000939 motif II; other site 882094000940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094000941 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094000942 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094000943 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882094000944 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 882094000945 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 882094000946 Walker A/P-loop; other site 882094000947 ATP binding site [chemical binding]; other site 882094000948 Q-loop/lid; other site 882094000949 ABC transporter signature motif; other site 882094000950 Walker B; other site 882094000951 D-loop; other site 882094000952 H-loop/switch region; other site 882094000953 TOBE domain; Region: TOBE; pfam03459 882094000954 ATP cone domain; Region: ATP-cone; pfam03477 882094000955 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 882094000956 Class III ribonucleotide reductase; Region: RNR_III; cd01675 882094000957 effector binding site; other site 882094000958 active site 882094000959 Zn binding site [ion binding]; other site 882094000960 glycine loop; other site 882094000961 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 882094000962 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 882094000963 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094000964 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094000965 ligand binding site [chemical binding]; other site 882094000966 flexible hinge region; other site 882094000967 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882094000968 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 882094000969 putative active site [active] 882094000970 catalytic triad [active] 882094000971 putative dimer interface [polypeptide binding]; other site 882094000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094000973 dimer interface [polypeptide binding]; other site 882094000974 conserved gate region; other site 882094000975 ABC-ATPase subunit interface; other site 882094000976 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 882094000977 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882094000978 Walker A/P-loop; other site 882094000979 ATP binding site [chemical binding]; other site 882094000980 Q-loop/lid; other site 882094000981 ABC transporter signature motif; other site 882094000982 Walker B; other site 882094000983 D-loop; other site 882094000984 H-loop/switch region; other site 882094000985 NIL domain; Region: NIL; pfam09383 882094000986 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882094000987 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882094000988 transaminase; Reviewed; Region: PRK08068 882094000989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094000990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094000991 homodimer interface [polypeptide binding]; other site 882094000992 catalytic residue [active] 882094000993 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094000994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094000995 active site 882094000996 phosphorylation site [posttranslational modification] 882094000997 intermolecular recognition site; other site 882094000998 dimerization interface [polypeptide binding]; other site 882094000999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094001000 DNA binding site [nucleotide binding] 882094001001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 882094001002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094001003 dimerization interface [polypeptide binding]; other site 882094001004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882094001005 putative active site [active] 882094001006 heme pocket [chemical binding]; other site 882094001007 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094001008 dimer interface [polypeptide binding]; other site 882094001009 phosphorylation site [posttranslational modification] 882094001010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094001011 ATP binding site [chemical binding]; other site 882094001012 Mg2+ binding site [ion binding]; other site 882094001013 G-X-G motif; other site 882094001014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 882094001015 YycH protein; Region: YycH; pfam07435 882094001016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 882094001017 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 882094001018 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882094001019 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882094001020 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 882094001021 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882094001022 protein binding site [polypeptide binding]; other site 882094001023 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 882094001024 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094001025 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094001026 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882094001027 dimerization interface [polypeptide binding]; other site 882094001028 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882094001029 dimer interface [polypeptide binding]; other site 882094001030 FMN binding site [chemical binding]; other site 882094001031 NADPH bind site [chemical binding]; other site 882094001032 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094001033 HTH domain; Region: HTH_11; pfam08279 882094001034 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094001035 PRD domain; Region: PRD; pfam00874 882094001036 PRD domain; Region: PRD; pfam00874 882094001037 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094001038 active site 882094001039 P-loop; other site 882094001040 phosphorylation site [posttranslational modification] 882094001041 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001042 active site 882094001043 phosphorylation site [posttranslational modification] 882094001044 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094001045 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094001046 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094001047 active site 882094001048 P-loop; other site 882094001049 phosphorylation site [posttranslational modification] 882094001050 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094001051 beta-galactosidase; Region: BGL; TIGR03356 882094001052 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094001053 methionine cluster; other site 882094001054 active site 882094001055 phosphorylation site [posttranslational modification] 882094001056 metal binding site [ion binding]; metal-binding site 882094001057 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 882094001058 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882094001059 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094001060 catalytic residue [active] 882094001061 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 882094001062 putative active site [active] 882094001063 YdjC motif; other site 882094001064 Mg binding site [ion binding]; other site 882094001065 putative homodimer interface [polypeptide binding]; other site 882094001066 Putative transcription activator [Transcription]; Region: TenA; COG0819 882094001067 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 882094001068 substrate binding site [chemical binding]; other site 882094001069 multimerization interface [polypeptide binding]; other site 882094001070 ATP binding site [chemical binding]; other site 882094001071 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882094001072 dimer interface [polypeptide binding]; other site 882094001073 substrate binding site [chemical binding]; other site 882094001074 ATP binding site [chemical binding]; other site 882094001075 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 882094001076 thiamine phosphate binding site [chemical binding]; other site 882094001077 active site 882094001078 pyrophosphate binding site [ion binding]; other site 882094001079 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094001080 beta-galactosidase; Region: BGL; TIGR03356 882094001081 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001082 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 882094001083 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 882094001084 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 882094001085 putative catalytic site [active] 882094001086 putative metal binding site [ion binding]; other site 882094001087 putative phosphate binding site [ion binding]; other site 882094001088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094001089 non-specific DNA binding site [nucleotide binding]; other site 882094001090 salt bridge; other site 882094001091 sequence-specific DNA binding site [nucleotide binding]; other site 882094001092 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882094001093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094001094 non-specific DNA binding site [nucleotide binding]; other site 882094001095 salt bridge; other site 882094001096 sequence-specific DNA binding site [nucleotide binding]; other site 882094001097 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882094001098 Leucine rich repeat; Region: LRR_8; pfam13855 882094001099 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001100 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001101 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001102 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001103 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001104 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001105 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001106 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001107 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001108 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001109 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001110 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001111 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001112 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001113 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001114 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001115 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001116 Leucine rich repeat; Region: LRR_8; pfam13855 882094001117 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001118 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001119 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094001120 Leucine-rich repeats; other site 882094001121 Substrate binding site [chemical binding]; other site 882094001122 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001123 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001124 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001125 Leucine rich repeat; Region: LRR_8; pfam13855 882094001126 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094001127 Leucine-rich repeats; other site 882094001128 Leucine rich repeat; Region: LRR_8; pfam13855 882094001129 Substrate binding site [chemical binding]; other site 882094001130 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001131 Leucine rich repeat; Region: LRR_8; pfam13855 882094001132 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001133 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001134 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001135 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001136 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001137 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001138 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001139 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 882094001140 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882094001141 LXG domain of WXG superfamily; Region: LXG; pfam04740 882094001142 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 882094001143 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882094001144 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882094001145 TPP-binding site [chemical binding]; other site 882094001146 dimer interface [polypeptide binding]; other site 882094001147 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882094001148 PYR/PP interface [polypeptide binding]; other site 882094001149 dimer interface [polypeptide binding]; other site 882094001150 TPP binding site [chemical binding]; other site 882094001151 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094001152 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882094001153 active site 882094001154 intersubunit interactions; other site 882094001155 catalytic residue [active] 882094001156 short chain dehydrogenase; Provisional; Region: PRK06841 882094001157 classical (c) SDRs; Region: SDR_c; cd05233 882094001158 NAD(P) binding site [chemical binding]; other site 882094001159 active site 882094001160 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882094001161 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882094001162 substrate binding site [chemical binding]; other site 882094001163 dimer interface [polypeptide binding]; other site 882094001164 catalytic triad [active] 882094001165 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882094001166 DAK2 domain; Region: Dak2; cl03685 882094001167 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 882094001168 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882094001169 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 882094001170 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094001171 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094001172 putative DNA binding site [nucleotide binding]; other site 882094001173 putative Zn2+ binding site [ion binding]; other site 882094001174 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094001175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094001176 Coenzyme A binding pocket [chemical binding]; other site 882094001177 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094001178 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882094001179 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001180 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001181 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001182 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882094001183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882094001184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 882094001185 acyl-activating enzyme (AAE) consensus motif; other site 882094001186 acyl-activating enzyme (AAE) consensus motif; other site 882094001187 AMP binding site [chemical binding]; other site 882094001188 active site 882094001189 CoA binding site [chemical binding]; other site 882094001190 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 882094001191 L-aspartate oxidase; Provisional; Region: PRK06175 882094001192 putative oxidoreductase; Provisional; Region: PRK10206 882094001193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094001194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882094001195 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001196 active site 882094001197 phosphorylation site [posttranslational modification] 882094001198 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 882094001199 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094001200 active site 882094001201 P-loop; other site 882094001202 phosphorylation site [posttranslational modification] 882094001203 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094001204 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882094001205 intersubunit interface [polypeptide binding]; other site 882094001206 active site 882094001207 zinc binding site [ion binding]; other site 882094001208 Na+ binding site [ion binding]; other site 882094001209 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094001210 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 882094001211 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094001212 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 882094001213 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 882094001214 Peptidase E [Amino acid transport and metabolism]; Region: PepE; COG3340 882094001215 conserved cys residue [active] 882094001216 Predicted transcriptional regulator [Transcription]; Region: COG2378 882094001217 HTH domain; Region: HTH_11; pfam08279 882094001218 WYL domain; Region: WYL; pfam13280 882094001219 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 882094001220 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 882094001221 Imelysin; Region: Peptidase_M75; pfam09375 882094001222 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 882094001223 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 882094001224 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 882094001225 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_34; cd04693 882094001226 nudix motif; other site 882094001227 hypothetical protein; Provisional; Region: PRK12378 882094001228 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 882094001229 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 882094001230 PhnA protein; Region: PhnA; pfam03831 882094001231 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094001232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094001233 DNA-binding site [nucleotide binding]; DNA binding site 882094001234 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882094001235 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094001236 beta-galactosidase; Region: BGL; TIGR03356 882094001237 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094001238 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882094001239 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094001240 active site 882094001241 P-loop; other site 882094001242 phosphorylation site [posttranslational modification] 882094001243 Predicted transcriptional regulator [Transcription]; Region: COG2378 882094001244 HTH domain; Region: HTH_11; pfam08279 882094001245 WYL domain; Region: WYL; pfam13280 882094001246 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 882094001247 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094001248 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882094001249 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094001250 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 882094001251 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 882094001252 tetrameric interface [polypeptide binding]; other site 882094001253 NAD binding site [chemical binding]; other site 882094001254 catalytic residues [active] 882094001255 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 882094001256 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882094001257 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 882094001258 substrate binding site [chemical binding]; other site 882094001259 ATP binding site [chemical binding]; other site 882094001260 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 882094001261 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882094001262 PYR/PP interface [polypeptide binding]; other site 882094001263 dimer interface [polypeptide binding]; other site 882094001264 TPP binding site [chemical binding]; other site 882094001265 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882094001266 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 882094001267 TPP-binding site; other site 882094001268 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882094001269 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 882094001270 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882094001271 ligand binding site [chemical binding]; other site 882094001272 active site 882094001273 UGI interface [polypeptide binding]; other site 882094001274 catalytic site [active] 882094001275 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 882094001276 hypothetical protein; Provisional; Region: PRK13665 882094001277 Bacterial SH3 domain; Region: SH3_3; cl17532 882094001278 NlpC/P60 family; Region: NLPC_P60; pfam00877 882094001279 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094001280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094001281 Coenzyme A binding pocket [chemical binding]; other site 882094001282 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 882094001283 pyrroline-5-carboxylate reductase; Region: PLN02688 882094001284 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094001285 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001286 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882094001287 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094001288 DNA-binding site [nucleotide binding]; DNA binding site 882094001289 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 882094001290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094001291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094001292 Walker A/P-loop; other site 882094001293 ATP binding site [chemical binding]; other site 882094001294 Q-loop/lid; other site 882094001295 ABC transporter signature motif; other site 882094001296 Walker B; other site 882094001297 D-loop; other site 882094001298 H-loop/switch region; other site 882094001299 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094001300 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882094001301 FtsX-like permease family; Region: FtsX; pfam02687 882094001302 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 882094001303 putative hydrophobic ligand binding site [chemical binding]; other site 882094001304 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001305 active site 882094001306 phosphorylation site [posttranslational modification] 882094001307 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094001308 active site 882094001309 P-loop; other site 882094001310 phosphorylation site [posttranslational modification] 882094001311 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094001312 alpha-mannosidase; Provisional; Region: PRK09819 882094001313 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882094001314 active site 882094001315 metal binding site [ion binding]; metal-binding site 882094001316 catalytic site [active] 882094001317 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882094001318 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094001319 HTH domain; Region: HTH_11; pfam08279 882094001320 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094001321 PRD domain; Region: PRD; pfam00874 882094001322 PRD domain; Region: PRD; pfam00874 882094001323 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094001324 active site 882094001325 P-loop; other site 882094001326 phosphorylation site [posttranslational modification] 882094001327 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001328 active site 882094001329 phosphorylation site [posttranslational modification] 882094001330 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882094001331 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 882094001332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094001333 putative metal binding site [ion binding]; other site 882094001334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 882094001335 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882094001336 trimer interface [polypeptide binding]; other site 882094001337 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094001338 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001339 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094001340 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001341 Leucine-rich repeats; other site 882094001342 Substrate binding site [chemical binding]; other site 882094001343 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001344 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001345 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001346 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001347 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001348 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001349 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001350 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001351 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001352 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001353 phosphoenolpyruvate synthase; Validated; Region: PRK06241 882094001354 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882094001355 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882094001356 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 882094001357 ZIP Zinc transporter; Region: Zip; pfam02535 882094001358 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 882094001359 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 882094001360 NodB motif; other site 882094001361 active site 882094001362 catalytic site [active] 882094001363 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094001364 non-specific DNA binding site [nucleotide binding]; other site 882094001365 salt bridge; other site 882094001366 sequence-specific DNA binding site [nucleotide binding]; other site 882094001367 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 882094001368 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094001369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094001370 active site 882094001371 motif I; other site 882094001372 motif II; other site 882094001373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094001374 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 882094001375 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094001376 HTH domain; Region: HTH_11; pfam08279 882094001377 PRD domain; Region: PRD; pfam00874 882094001378 PRD domain; Region: PRD; pfam00874 882094001379 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094001380 active site 882094001381 P-loop; other site 882094001382 phosphorylation site [posttranslational modification] 882094001383 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001384 active site 882094001385 phosphorylation site [posttranslational modification] 882094001386 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001387 active site 882094001388 phosphorylation site [posttranslational modification] 882094001389 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094001390 active site 882094001391 P-loop; other site 882094001392 phosphorylation site [posttranslational modification] 882094001393 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094001394 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882094001395 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882094001396 active site 882094001397 metal binding site [ion binding]; metal-binding site 882094001398 catalytic site [active] 882094001399 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882094001400 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094001401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094001402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882094001403 dimerization interface [polypeptide binding]; other site 882094001404 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882094001405 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882094001406 active site 882094001407 substrate binding site [chemical binding]; other site 882094001408 trimer interface [polypeptide binding]; other site 882094001409 CoA binding site [chemical binding]; other site 882094001410 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 882094001411 classical (c) SDRs; Region: SDR_c; cd05233 882094001412 NAD(P) binding site [chemical binding]; other site 882094001413 active site 882094001414 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 882094001415 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 882094001416 RHS Repeat; Region: RHS_repeat; pfam05593 882094001417 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 882094001418 RHS Repeat; Region: RHS_repeat; pfam05593 882094001419 RHS Repeat; Region: RHS_repeat; pfam05593 882094001420 RHS Repeat; Region: RHS_repeat; pfam05593 882094001421 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 882094001422 HEAT repeats; Region: HEAT_2; pfam13646 882094001423 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094001424 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001425 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094001426 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001427 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001428 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001429 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001430 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001431 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001432 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001433 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001434 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001435 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001436 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 882094001437 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094001438 Leucine rich repeat; Region: LRR_8; pfam13855 882094001439 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094001440 Leucine rich repeat; Region: LRR_8; pfam13855 882094001441 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001442 LRR adjacent; Region: LRR_adjacent; pfam08191 882094001443 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001444 SH3-like domain; Region: SH3_8; pfam13457 882094001445 Predicted transcriptional regulator [Transcription]; Region: COG1959 882094001446 Transcriptional regulator; Region: Rrf2; pfam02082 882094001447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882094001448 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 882094001449 NAD(P) binding site [chemical binding]; other site 882094001450 active site 882094001451 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 882094001452 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 882094001453 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 882094001454 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882094001455 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882094001456 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882094001457 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882094001458 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 882094001459 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 882094001460 Predicted membrane protein [Function unknown]; Region: COG3619 882094001461 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 882094001462 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 882094001463 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 882094001464 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 882094001465 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 882094001466 Protein of unknown function DUF58; Region: DUF58; pfam01882 882094001467 MoxR-like ATPases [General function prediction only]; Region: COG0714 882094001468 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094001469 Walker A motif; other site 882094001470 ATP binding site [chemical binding]; other site 882094001471 Walker B motif; other site 882094001472 arginine finger; other site 882094001473 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882094001474 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882094001475 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 882094001476 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 882094001477 Na binding site [ion binding]; other site 882094001478 Uncharacterized conserved protein [Function unknown]; Region: COG3535 882094001479 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 882094001480 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094001481 nucleotide binding site [chemical binding]; other site 882094001482 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 882094001483 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094001484 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094001485 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001486 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001487 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001488 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094001489 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001490 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001491 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001492 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001493 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001494 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001495 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001496 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094001497 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001498 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001499 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001500 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001501 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001502 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094001503 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001504 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001505 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001506 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094001507 Leucine rich repeat; Region: LRR_8; pfam13855 882094001508 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094001509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094001510 Zn2+ binding site [ion binding]; other site 882094001511 Mg2+ binding site [ion binding]; other site 882094001512 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 882094001513 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 882094001514 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 882094001515 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094001516 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 882094001517 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 882094001518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882094001519 FeS/SAM binding site; other site 882094001520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 882094001521 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 882094001522 LXG domain of WXG superfamily; Region: LXG; pfam04740 882094001523 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 882094001524 putative FMN binding site [chemical binding]; other site 882094001525 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 882094001526 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 882094001527 nudix motif; other site 882094001528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094001529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094001530 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882094001531 putative dimerization interface [polypeptide binding]; other site 882094001532 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882094001533 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882094001534 active site 882094001535 FMN binding site [chemical binding]; other site 882094001536 substrate binding site [chemical binding]; other site 882094001537 putative catalytic residue [active] 882094001538 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 882094001539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094001540 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094001541 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882094001542 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882094001543 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882094001544 shikimate binding site; other site 882094001545 NAD(P) binding site [chemical binding]; other site 882094001546 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 882094001547 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 882094001548 active site 882094001549 catalytic residue [active] 882094001550 dimer interface [polypeptide binding]; other site 882094001551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094001552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094001553 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 882094001554 dimerization interface [polypeptide binding]; other site 882094001555 substrate binding pocket [chemical binding]; other site 882094001556 Predicted acyl esterases [General function prediction only]; Region: COG2936 882094001557 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 882094001558 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 882094001559 active site 882094001560 catalytic triad [active] 882094001561 oxyanion hole [active] 882094001562 EamA-like transporter family; Region: EamA; pfam00892 882094001563 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 882094001564 EamA-like transporter family; Region: EamA; pfam00892 882094001565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4224 882094001566 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882094001567 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882094001568 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882094001569 substrate binding site [chemical binding]; other site 882094001570 hexamer interface [polypeptide binding]; other site 882094001571 metal binding site [ion binding]; metal-binding site 882094001572 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882094001573 catalytic residue [active] 882094001574 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094001575 PRD domain; Region: PRD; pfam00874 882094001576 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094001577 active site 882094001578 P-loop; other site 882094001579 phosphorylation site [posttranslational modification] 882094001580 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001581 active site 882094001582 phosphorylation site [posttranslational modification] 882094001583 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 882094001584 putative active site [active] 882094001585 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094001586 active site 882094001587 phosphorylation site [posttranslational modification] 882094001588 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882094001589 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882094001590 substrate binding site [chemical binding]; other site 882094001591 hexamer interface [polypeptide binding]; other site 882094001592 metal binding site [ion binding]; metal-binding site 882094001593 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882094001594 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882094001595 putative NAD(P) binding site [chemical binding]; other site 882094001596 catalytic Zn binding site [ion binding]; other site 882094001597 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882094001598 active site 882094001599 P-loop; other site 882094001600 phosphorylation site [posttranslational modification] 882094001601 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882094001602 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882094001603 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 882094001604 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 882094001605 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094001606 active site 882094001607 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 882094001608 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 882094001609 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 882094001610 catalytic triad [active] 882094001611 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 882094001612 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094001613 MarR family; Region: MarR_2; pfam12802 882094001614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001615 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001616 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882094001617 Ligand Binding Site [chemical binding]; other site 882094001618 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 882094001619 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 882094001620 putative active site [active] 882094001621 putative metal binding site [ion binding]; other site 882094001622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001623 catalytic core [active] 882094001624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001625 Predicted membrane protein [Function unknown]; Region: COG3759 882094001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094001627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094001628 putative substrate translocation pore; other site 882094001629 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882094001630 non-specific DNA interactions [nucleotide binding]; other site 882094001631 DNA binding site [nucleotide binding] 882094001632 sequence specific DNA binding site [nucleotide binding]; other site 882094001633 putative cAMP binding site [chemical binding]; other site 882094001634 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094001635 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882094001636 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 882094001637 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 882094001638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094001639 ATP binding site [chemical binding]; other site 882094001640 putative Mg++ binding site [ion binding]; other site 882094001641 HsdM N-terminal domain; Region: HsdM_N; pfam12161 882094001642 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 882094001643 Methyltransferase domain; Region: Methyltransf_26; pfam13659 882094001644 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 882094001645 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 882094001646 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 882094001647 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 882094001648 Int/Topo IB signature motif; other site 882094001649 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 882094001650 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 882094001651 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 882094001652 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882094001653 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882094001654 NAD binding site [chemical binding]; other site 882094001655 sugar binding site [chemical binding]; other site 882094001656 divalent metal binding site [ion binding]; other site 882094001657 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094001658 dimer interface [polypeptide binding]; other site 882094001659 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094001660 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094001661 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094001662 putative active site [active] 882094001663 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882094001664 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882094001665 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882094001666 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882094001667 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 882094001668 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882094001669 DNA binding residues [nucleotide binding] 882094001670 dimer interface [polypeptide binding]; other site 882094001671 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 882094001672 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 882094001673 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 882094001674 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 882094001675 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 882094001676 DXD motif; other site 882094001677 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882094001678 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 882094001679 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882094001680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094001681 S-adenosylmethionine binding site [chemical binding]; other site 882094001682 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 882094001683 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 882094001684 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094001685 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094001686 DNA binding site [nucleotide binding] 882094001687 domain linker motif; other site 882094001688 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882094001689 putative dimerization interface [polypeptide binding]; other site 882094001690 putative ligand binding site [chemical binding]; other site 882094001691 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882094001692 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 882094001693 NAD binding site [chemical binding]; other site 882094001694 sugar binding site [chemical binding]; other site 882094001695 divalent metal binding site [ion binding]; other site 882094001696 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094001697 dimer interface [polypeptide binding]; other site 882094001698 allantoate amidohydrolase; Reviewed; Region: PRK09290 882094001699 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 882094001700 active site 882094001701 metal binding site [ion binding]; metal-binding site 882094001702 dimer interface [polypeptide binding]; other site 882094001703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882094001704 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_subfamily5; cd08019 882094001705 metal binding site [ion binding]; metal-binding site 882094001706 putative dimer interface [polypeptide binding]; other site 882094001707 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 882094001708 Beta-lactamase; Region: Beta-lactamase; pfam00144 882094001709 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882094001710 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882094001711 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882094001712 intersubunit interface [polypeptide binding]; other site 882094001713 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 882094001714 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 882094001715 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 882094001716 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 882094001717 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 882094001718 Glucitol operon activator protein (GutM); Region: GutM; cl01890 882094001719 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 882094001720 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094001721 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 882094001722 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882094001723 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882094001724 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094001725 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 882094001726 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001727 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001728 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001729 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094001730 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882094001731 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882094001732 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882094001733 FOG: CBS domain [General function prediction only]; Region: COG0517 882094001734 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 882094001735 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 882094001736 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 882094001737 dimer interface [polypeptide binding]; other site 882094001738 active site 882094001739 metal binding site [ion binding]; metal-binding site 882094001740 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 882094001741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094001742 putative substrate translocation pore; other site 882094001743 POT family; Region: PTR2; pfam00854 882094001744 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001745 catalytic core [active] 882094001746 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001748 catalytic core [active] 882094001749 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094001750 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 882094001751 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 882094001752 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882094001753 Cl binding site [ion binding]; other site 882094001754 oligomer interface [polypeptide binding]; other site 882094001755 glutamate dehydrogenase; Provisional; Region: PRK09414 882094001756 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 882094001757 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 882094001758 NAD(P) binding site [chemical binding]; other site 882094001759 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 882094001760 metal binding site [ion binding]; metal-binding site 882094001761 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 882094001762 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 882094001763 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 882094001764 substrate binding site [chemical binding]; other site 882094001765 glutamase interaction surface [polypeptide binding]; other site 882094001766 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 882094001767 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 882094001768 catalytic residues [active] 882094001769 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 882094001770 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 882094001771 putative active site [active] 882094001772 oxyanion strand; other site 882094001773 catalytic triad [active] 882094001774 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 882094001775 putative active site pocket [active] 882094001776 4-fold oligomerization interface [polypeptide binding]; other site 882094001777 metal binding residues [ion binding]; metal-binding site 882094001778 3-fold/trimer interface [polypeptide binding]; other site 882094001779 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 882094001780 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 882094001781 NAD binding site [chemical binding]; other site 882094001782 dimerization interface [polypeptide binding]; other site 882094001783 product binding site; other site 882094001784 substrate binding site [chemical binding]; other site 882094001785 zinc binding site [ion binding]; other site 882094001786 catalytic residues [active] 882094001787 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 882094001788 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 882094001789 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 882094001790 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882094001791 dimer interface [polypeptide binding]; other site 882094001792 motif 1; other site 882094001793 active site 882094001794 motif 2; other site 882094001795 motif 3; other site 882094001796 histidinol-phosphatase; Reviewed; Region: PRK08123 882094001797 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 882094001798 active site 882094001799 dimer interface [polypeptide binding]; other site 882094001800 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882094001801 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882094001802 DNA binding site [nucleotide binding] 882094001803 active site 882094001804 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 882094001805 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882094001806 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094001807 beta-galactosidase; Region: BGL; TIGR03356 882094001808 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094001809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094001810 DNA-binding site [nucleotide binding]; DNA binding site 882094001811 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882094001812 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001813 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094001814 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 882094001815 Uncharacterized conserved protein [Function unknown]; Region: COG2966 882094001816 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 882094001817 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 882094001818 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 882094001819 Predicted esterase [General function prediction only]; Region: COG0400 882094001820 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 882094001821 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 882094001822 putative RNA binding site [nucleotide binding]; other site 882094001823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094001824 S-adenosylmethionine binding site [chemical binding]; other site 882094001825 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 882094001826 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094001827 Bacterial SH3 domain; Region: SH3_3; pfam08239 882094001828 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094001829 NlpC/P60 family; Region: NLPC_P60; pfam00877 882094001830 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 882094001831 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882094001832 ATP binding site [chemical binding]; other site 882094001833 putative Mg++ binding site [ion binding]; other site 882094001834 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882094001835 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 882094001836 nucleotide binding region [chemical binding]; other site 882094001837 ATP-binding site [chemical binding]; other site 882094001838 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882094001839 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882094001840 WxL domain surface cell wall-binding; Region: WxL; pfam13731 882094001841 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 882094001842 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 882094001843 UreD urease accessory protein; Region: UreD; cl00530 882094001844 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 882094001845 DNA photolyase; Region: DNA_photolyase; pfam00875 882094001846 Predicted membrane protein [Function unknown]; Region: COG4852 882094001847 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 882094001848 DAK2 domain; Region: Dak2; pfam02734 882094001849 EDD domain protein, DegV family; Region: DegV; TIGR00762 882094001850 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882094001851 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 882094001852 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882094001853 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 882094001854 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 882094001855 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 882094001856 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882094001857 homodimer interface [polypeptide binding]; other site 882094001858 substrate-cofactor binding pocket; other site 882094001859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094001860 catalytic residue [active] 882094001861 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882094001862 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094001863 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882094001864 ligand binding site [chemical binding]; other site 882094001865 flexible hinge region; other site 882094001866 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094001867 BioY family; Region: BioY; pfam02632 882094001868 Predicted transcriptional regulators [Transcription]; Region: COG1695 882094001869 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882094001870 Predicted membrane protein [Function unknown]; Region: COG4709 882094001871 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882094001872 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882094001873 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882094001874 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882094001875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882094001876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094001877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882094001878 Coenzyme A binding pocket [chemical binding]; other site 882094001879 Tic20-like protein; Region: Tic20; pfam09685 882094001880 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 882094001881 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882094001882 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882094001883 MarR family; Region: MarR_2; pfam12802 882094001884 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094001885 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094001886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094001887 Walker A/P-loop; other site 882094001888 ATP binding site [chemical binding]; other site 882094001889 Q-loop/lid; other site 882094001890 ABC transporter signature motif; other site 882094001891 Walker B; other site 882094001892 D-loop; other site 882094001893 H-loop/switch region; other site 882094001894 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094001895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094001896 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882094001897 Walker A/P-loop; other site 882094001898 ATP binding site [chemical binding]; other site 882094001899 Q-loop/lid; other site 882094001900 ABC transporter signature motif; other site 882094001901 Walker B; other site 882094001902 D-loop; other site 882094001903 H-loop/switch region; other site 882094001904 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882094001905 active site residue [active] 882094001906 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094001907 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882094001908 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882094001909 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882094001910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094001911 putative DNA binding site [nucleotide binding]; other site 882094001912 putative Zn2+ binding site [ion binding]; other site 882094001913 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 882094001914 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 882094001915 putative NAD(P) binding site [chemical binding]; other site 882094001916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 882094001917 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882094001918 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 882094001919 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882094001920 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 882094001921 putative active site [active] 882094001922 catalytic site [active] 882094001923 putative metal binding site [ion binding]; other site 882094001924 Catalytic domain of Protein Kinases; Region: PKc; cd00180 882094001925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882094001926 active site 882094001927 ATP binding site [chemical binding]; other site 882094001928 substrate binding site [chemical binding]; other site 882094001929 activation loop (A-loop); other site 882094001930 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 882094001931 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 882094001932 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882094001933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882094001934 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094001935 Coenzyme A binding pocket [chemical binding]; other site 882094001936 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 882094001937 active site 882094001938 catalytic triad [active] 882094001939 oxyanion hole [active] 882094001940 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882094001941 domain interaction interfaces [polypeptide binding]; other site 882094001942 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882094001943 domain interaction interfaces [polypeptide binding]; other site 882094001944 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882094001945 domain interaction interfaces [polypeptide binding]; other site 882094001946 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 882094001947 domain interaction interfaces [polypeptide binding]; other site 882094001948 Isochorismatase family; Region: Isochorismatase; pfam00857 882094001949 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 882094001950 catalytic triad [active] 882094001951 conserved cis-peptide bond; other site 882094001952 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 882094001953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094001954 motif II; other site 882094001955 Predicted transcriptional regulator [Transcription]; Region: COG1959 882094001956 Transcriptional regulator; Region: Rrf2; pfam02082 882094001957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094001958 S-adenosylmethionine binding site [chemical binding]; other site 882094001959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882094001960 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882094001961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094001962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094001963 active site 882094001964 catalytic tetrad [active] 882094001965 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 882094001966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094001967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094001968 motif II; other site 882094001969 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 882094001970 catalytic residue [active] 882094001971 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882094001972 Sulfatase; Region: Sulfatase; pfam00884 882094001973 amino acid transporter; Region: 2A0306; TIGR00909 882094001974 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882094001975 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 882094001976 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 882094001977 putative metal binding site [ion binding]; other site 882094001978 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 882094001979 active site 882094001980 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882094001981 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882094001982 Cl binding site [ion binding]; other site 882094001983 oligomer interface [polypeptide binding]; other site 882094001984 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882094001985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094001986 DNA-binding site [nucleotide binding]; DNA binding site 882094001987 Predicted membrane protein [Function unknown]; Region: COG1511 882094001988 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882094001989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094001990 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882094001991 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094001992 DNA-binding site [nucleotide binding]; DNA binding site 882094001993 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882094001994 Predicted integral membrane protein [Function unknown]; Region: COG5523 882094001995 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882094001996 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 882094001997 active site 882094001998 metal binding site [ion binding]; metal-binding site 882094001999 Predicted membrane protein [Function unknown]; Region: COG2322 882094002000 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 882094002001 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 882094002002 cofactor binding site; other site 882094002003 DNA binding site [nucleotide binding] 882094002004 substrate interaction site [chemical binding]; other site 882094002005 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 882094002006 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 882094002007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882094002008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094002009 ATP binding site [chemical binding]; other site 882094002010 Mg2+ binding site [ion binding]; other site 882094002011 G-X-G motif; other site 882094002012 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 882094002013 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882094002014 minor groove reading motif; other site 882094002015 helix-hairpin-helix signature motif; other site 882094002016 substrate binding pocket [chemical binding]; other site 882094002017 active site 882094002018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094002019 non-specific DNA binding site [nucleotide binding]; other site 882094002020 salt bridge; other site 882094002021 sequence-specific DNA binding site [nucleotide binding]; other site 882094002022 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882094002023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 882094002024 Transposase; Region: HTH_Tnp_1; cl17663 882094002025 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094002026 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002027 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002028 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 882094002029 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 882094002030 dimer interface [polypeptide binding]; other site 882094002031 substrate binding site [chemical binding]; other site 882094002032 ATP binding site [chemical binding]; other site 882094002033 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094002034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094002035 active site 882094002036 motif I; other site 882094002037 motif II; other site 882094002038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094002039 maltose O-acetyltransferase; Provisional; Region: PRK10092 882094002040 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 882094002041 active site 882094002042 substrate binding site [chemical binding]; other site 882094002043 trimer interface [polypeptide binding]; other site 882094002044 CoA binding site [chemical binding]; other site 882094002045 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 882094002046 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094002047 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 882094002048 Walker A/P-loop; other site 882094002049 ATP binding site [chemical binding]; other site 882094002050 Q-loop/lid; other site 882094002051 ABC transporter signature motif; other site 882094002052 Walker B; other site 882094002053 D-loop; other site 882094002054 H-loop/switch region; other site 882094002055 inner membrane transport permease; Provisional; Region: PRK15066 882094002056 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882094002057 oxidoreductase; Provisional; Region: PRK07985 882094002058 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882094002059 NAD(P) binding site [chemical binding]; other site 882094002060 active site 882094002061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 882094002062 Predicted membrane protein [Function unknown]; Region: COG3152 882094002063 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 882094002064 Flagellar biosynthesis pathway, component FliP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliP; COG1338 882094002065 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 882094002066 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 882094002067 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 882094002068 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 882094002069 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 882094002070 FHIPEP family; Region: FHIPEP; pfam00771 882094002071 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 882094002072 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882094002073 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 882094002074 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882094002075 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 882094002076 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 882094002077 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 882094002078 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 882094002079 flagellar motor protein MotA; Validated; Region: PRK08124 882094002080 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 882094002081 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 882094002082 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 882094002083 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 882094002084 ligand binding site [chemical binding]; other site 882094002085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882094002086 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 882094002087 putative metal binding site; other site 882094002088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094002089 binding surface 882094002090 TPR motif; other site 882094002091 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 882094002092 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 882094002093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094002094 active site 882094002095 phosphorylation site [posttranslational modification] 882094002096 intermolecular recognition site; other site 882094002097 dimerization interface [polypeptide binding]; other site 882094002098 flagellin; Provisional; Region: PRK12805 882094002099 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882094002100 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 882094002101 Response regulator receiver domain; Region: Response_reg; pfam00072 882094002102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094002103 active site 882094002104 phosphorylation site [posttranslational modification] 882094002105 intermolecular recognition site; other site 882094002106 dimerization interface [polypeptide binding]; other site 882094002107 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 882094002108 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 882094002109 putative binding surface; other site 882094002110 active site 882094002111 P2 response regulator binding domain; Region: P2; pfam07194 882094002112 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 882094002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094002114 ATP binding site [chemical binding]; other site 882094002115 Mg2+ binding site [ion binding]; other site 882094002116 G-X-G motif; other site 882094002117 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 882094002118 flagellar motor switch protein; Validated; Region: PRK06788 882094002119 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 882094002120 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 882094002121 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 882094002122 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 882094002123 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 882094002124 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 882094002125 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882094002126 flagellar motor switch protein; Validated; Region: PRK06789 882094002127 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 882094002128 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 882094002129 flagellar motor switch protein; Reviewed; Region: PRK06782 882094002130 CheC-like family; Region: CheC; pfam04509 882094002131 CheC-like family; Region: CheC; pfam04509 882094002132 Chemotaxis phosphatase CheX; Region: CheX; cl15816 882094002133 CheC-like family; Region: CheC; pfam04509 882094002134 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 882094002135 Protein of unknown function (DUF327); Region: DUF327; pfam03885 882094002136 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 882094002137 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882094002138 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 882094002139 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 882094002140 flagellar capping protein; Validated; Region: fliD; PRK06798 882094002141 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 882094002142 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 882094002143 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 882094002144 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 882094002145 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 882094002146 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 882094002147 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 882094002148 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 882094002149 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 882094002150 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 882094002151 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 882094002152 FliG C-terminal domain; Region: FliG_C; pfam01706 882094002153 flagellar assembly protein H; Validated; Region: fliH; PRK06800 882094002154 Flagellar assembly protein FliH; Region: FliH; pfam02108 882094002155 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 882094002156 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882094002157 Walker A motif; other site 882094002158 ATP binding site [chemical binding]; other site 882094002159 Walker B motif; other site 882094002160 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 882094002161 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 882094002162 N-acetyl-D-glucosamine binding site [chemical binding]; other site 882094002163 catalytic residue [active] 882094002164 Predicted transcriptional regulators [Transcription]; Region: COG1695 882094002165 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 882094002166 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 882094002167 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 882094002168 pyruvate oxidase; Provisional; Region: PRK08611 882094002169 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 882094002170 PYR/PP interface [polypeptide binding]; other site 882094002171 dimer interface [polypeptide binding]; other site 882094002172 tetramer interface [polypeptide binding]; other site 882094002173 TPP binding site [chemical binding]; other site 882094002174 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882094002175 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 882094002176 TPP-binding site [chemical binding]; other site 882094002177 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 882094002178 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882094002179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094002180 dimerization interface [polypeptide binding]; other site 882094002181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882094002182 dimer interface [polypeptide binding]; other site 882094002183 putative CheW interface [polypeptide binding]; other site 882094002184 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 882094002185 putative active site [active] 882094002186 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 882094002187 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 882094002188 glutaminase active site [active] 882094002189 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882094002190 dimer interface [polypeptide binding]; other site 882094002191 active site 882094002192 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882094002193 dimer interface [polypeptide binding]; other site 882094002194 active site 882094002195 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 882094002196 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882094002197 active site 882094002198 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 882094002199 GIY-YIG motif/motif A; other site 882094002200 Leucine rich repeat; Region: LRR_8; pfam13855 882094002201 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002202 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002203 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882094002205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094002206 non-specific DNA binding site [nucleotide binding]; other site 882094002207 salt bridge; other site 882094002208 sequence-specific DNA binding site [nucleotide binding]; other site 882094002209 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094002210 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094002211 ligand binding site [chemical binding]; other site 882094002212 flexible hinge region; other site 882094002213 Predicted transcriptional regulators [Transcription]; Region: COG1725 882094002214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002215 DNA-binding site [nucleotide binding]; DNA binding site 882094002216 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882094002217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094002218 Walker A/P-loop; other site 882094002219 ATP binding site [chemical binding]; other site 882094002220 Q-loop/lid; other site 882094002221 ABC transporter signature motif; other site 882094002222 Walker B; other site 882094002223 D-loop; other site 882094002224 H-loop/switch region; other site 882094002225 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094002226 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094002227 Walker A/P-loop; other site 882094002228 ATP binding site [chemical binding]; other site 882094002229 Q-loop/lid; other site 882094002230 ABC transporter signature motif; other site 882094002231 Walker B; other site 882094002232 D-loop; other site 882094002233 H-loop/switch region; other site 882094002234 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882094002235 FtsX-like permease family; Region: FtsX; pfam02687 882094002236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882094002237 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094002238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 882094002239 ligand binding site [chemical binding]; other site 882094002240 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882094002241 non-specific DNA interactions [nucleotide binding]; other site 882094002242 DNA binding site [nucleotide binding] 882094002243 sequence specific DNA binding site [nucleotide binding]; other site 882094002244 putative cAMP binding site [chemical binding]; other site 882094002245 SnoaL-like domain; Region: SnoaL_4; pfam13577 882094002246 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882094002247 active site 882094002248 catalytic triad [active] 882094002249 oxyanion hole [active] 882094002250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094002251 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094002252 Walker A/P-loop; other site 882094002253 ATP binding site [chemical binding]; other site 882094002254 Q-loop/lid; other site 882094002255 ABC transporter signature motif; other site 882094002256 Walker B; other site 882094002257 D-loop; other site 882094002258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882094002259 H-loop/switch region; other site 882094002260 active site 882094002261 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 882094002262 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882094002263 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882094002264 Zn binding site [ion binding]; other site 882094002265 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882094002266 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094002267 Zn binding site [ion binding]; other site 882094002268 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 882094002269 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094002270 Zn binding site [ion binding]; other site 882094002271 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 882094002272 Zn binding site [ion binding]; other site 882094002273 Predicted esterase [General function prediction only]; Region: COG0400 882094002274 putative hydrolase; Provisional; Region: PRK11460 882094002275 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 882094002276 GTPases [General function prediction only]; Region: HflX; COG2262 882094002277 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882094002278 HflX GTPase family; Region: HflX; cd01878 882094002279 G1 box; other site 882094002280 GTP/Mg2+ binding site [chemical binding]; other site 882094002281 Switch I region; other site 882094002282 G2 box; other site 882094002283 G3 box; other site 882094002284 Switch II region; other site 882094002285 G4 box; other site 882094002286 G5 box; other site 882094002287 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882094002288 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882094002289 putative active site [active] 882094002290 putative metal binding site [ion binding]; other site 882094002291 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882094002292 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882094002293 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882094002294 Uncharacterized conserved protein [Function unknown]; Region: COG3538 882094002295 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 882094002296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882094002297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002298 putative PBP binding loops; other site 882094002299 ABC-ATPase subunit interface; other site 882094002300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002302 dimer interface [polypeptide binding]; other site 882094002303 conserved gate region; other site 882094002304 putative PBP binding loops; other site 882094002305 ABC-ATPase subunit interface; other site 882094002306 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882094002307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 882094002308 Predicted glycosyl hydrolase [Carbohydrate transport and metabolism]; Region: COG4833 882094002309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002310 DNA-binding site [nucleotide binding]; DNA binding site 882094002311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094002312 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882094002313 ligand binding site [chemical binding]; other site 882094002314 dimerization interface [polypeptide binding]; other site 882094002315 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882094002316 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002317 DNA-binding site [nucleotide binding]; DNA binding site 882094002318 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 882094002319 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 882094002320 putative NADP binding site [chemical binding]; other site 882094002321 putative dimer interface [polypeptide binding]; other site 882094002322 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 882094002323 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882094002324 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094002325 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094002326 nucleotide binding site [chemical binding]; other site 882094002327 Predicted membrane protein [Function unknown]; Region: COG4811 882094002328 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 882094002329 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 882094002330 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882094002331 active site 882094002332 phosphorylation site [posttranslational modification] 882094002333 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094002334 active pocket/dimerization site; other site 882094002335 active site 882094002336 phosphorylation site [posttranslational modification] 882094002337 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882094002338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094002339 Walker A motif; other site 882094002340 ATP binding site [chemical binding]; other site 882094002341 Walker B motif; other site 882094002342 arginine finger; other site 882094002343 Transcriptional antiterminator [Transcription]; Region: COG3933 882094002344 PRD domain; Region: PRD; pfam00874 882094002345 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094002346 active pocket/dimerization site; other site 882094002347 active site 882094002348 phosphorylation site [posttranslational modification] 882094002349 PRD domain; Region: PRD; pfam00874 882094002350 Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182 882094002351 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882094002352 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 882094002353 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882094002354 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 882094002355 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 882094002356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 882094002357 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 882094002358 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 882094002359 Leucine rich repeat; Region: LRR_8; pfam13855 882094002360 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002361 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002362 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002363 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002364 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002365 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094002366 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 882094002367 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882094002368 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 882094002369 putative deacylase active site [active] 882094002370 Predicted amidohydrolase [General function prediction only]; Region: COG0388 882094002371 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 882094002372 active site 882094002373 catalytic triad [active] 882094002374 dimer interface [polypeptide binding]; other site 882094002375 Protein of unknown function (DUF554); Region: DUF554; pfam04474 882094002376 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 882094002377 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882094002378 NAD binding site [chemical binding]; other site 882094002379 substrate binding site [chemical binding]; other site 882094002380 putative active site [active] 882094002381 Predicted permeases [General function prediction only]; Region: RarD; COG2962 882094002382 EamA-like transporter family; Region: EamA; pfam00892 882094002383 Uncharacterized conserved protein [Function unknown]; Region: COG2353 882094002384 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882094002385 MarR family; Region: MarR_2; pfam12802 882094002386 lysine transporter; Provisional; Region: PRK10836 882094002387 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882094002388 PAS domain; Region: PAS_9; pfam13426 882094002389 putative active site [active] 882094002390 heme pocket [chemical binding]; other site 882094002391 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094002392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 882094002393 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882094002394 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882094002395 synthetase active site [active] 882094002396 NTP binding site [chemical binding]; other site 882094002397 metal binding site [ion binding]; metal-binding site 882094002398 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882094002399 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 882094002400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094002401 non-specific DNA binding site [nucleotide binding]; other site 882094002402 salt bridge; other site 882094002403 sequence-specific DNA binding site [nucleotide binding]; other site 882094002404 Cupin domain; Region: Cupin_2; pfam07883 882094002405 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 882094002406 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 882094002407 Walker A/P-loop; other site 882094002408 ATP binding site [chemical binding]; other site 882094002409 Q-loop/lid; other site 882094002410 ABC transporter signature motif; other site 882094002411 Walker B; other site 882094002412 D-loop; other site 882094002413 H-loop/switch region; other site 882094002414 TOBE domain; Region: TOBE_2; pfam08402 882094002415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002416 dimer interface [polypeptide binding]; other site 882094002417 conserved gate region; other site 882094002418 putative PBP binding loops; other site 882094002419 ABC-ATPase subunit interface; other site 882094002420 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 882094002421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002422 dimer interface [polypeptide binding]; other site 882094002423 conserved gate region; other site 882094002424 putative PBP binding loops; other site 882094002425 ABC-ATPase subunit interface; other site 882094002426 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 882094002427 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 882094002428 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 882094002429 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 882094002430 active site 882094002431 zinc binding site [ion binding]; other site 882094002432 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882094002433 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094002434 Zn2+ binding site [ion binding]; other site 882094002435 Mg2+ binding site [ion binding]; other site 882094002436 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094002437 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094002438 nucleotide binding site [chemical binding]; other site 882094002439 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882094002440 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882094002441 FMN binding site [chemical binding]; other site 882094002442 substrate binding site [chemical binding]; other site 882094002443 putative catalytic residue [active] 882094002444 Protein of unknown function (DUF3130; Region: DUF3130; pfam11328 882094002445 LXG domain of WXG superfamily; Region: LXG; pfam04740 882094002446 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882094002447 dimer interface [polypeptide binding]; other site 882094002448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094002449 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 882094002450 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882094002451 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094002452 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882094002453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094002454 motif II; other site 882094002455 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882094002456 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094002457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094002458 Coenzyme A binding pocket [chemical binding]; other site 882094002459 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 882094002460 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094002461 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094002462 DNA binding residues [nucleotide binding] 882094002463 putative dimer interface [polypeptide binding]; other site 882094002464 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094002465 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094002466 active site 882094002467 catalytic tetrad [active] 882094002468 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882094002469 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 882094002470 homodimer interface [polypeptide binding]; other site 882094002471 catalytic residues [active] 882094002472 NAD binding site [chemical binding]; other site 882094002473 substrate binding pocket [chemical binding]; other site 882094002474 flexible flap; other site 882094002475 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 882094002476 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882094002477 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 882094002478 PhoU domain; Region: PhoU; pfam01895 882094002479 PhoU domain; Region: PhoU; pfam01895 882094002480 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 882094002481 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 882094002482 dimer interface [polypeptide binding]; other site 882094002483 PYR/PP interface [polypeptide binding]; other site 882094002484 TPP binding site [chemical binding]; other site 882094002485 substrate binding site [chemical binding]; other site 882094002486 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 882094002487 Domain of unknown function; Region: EKR; smart00890 882094002488 4Fe-4S binding domain; Region: Fer4_6; pfam12837 882094002489 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 882094002490 TPP-binding site [chemical binding]; other site 882094002491 dimer interface [polypeptide binding]; other site 882094002492 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 882094002493 Predicted permeases [General function prediction only]; Region: COG0679 882094002494 Helix-turn-helix domain; Region: HTH_28; pfam13518 882094002495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094002496 non-specific DNA binding site [nucleotide binding]; other site 882094002497 salt bridge; other site 882094002498 sequence-specific DNA binding site [nucleotide binding]; other site 882094002499 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882094002500 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002501 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094002502 Predicted membrane protein [Function unknown]; Region: COG3223 882094002503 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094002504 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094002505 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 882094002506 Walker A/P-loop; other site 882094002507 ATP binding site [chemical binding]; other site 882094002508 Q-loop/lid; other site 882094002509 ABC transporter signature motif; other site 882094002510 Walker B; other site 882094002511 D-loop; other site 882094002512 H-loop/switch region; other site 882094002513 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 882094002514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002515 putative substrate translocation pore; other site 882094002516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094002519 putative substrate translocation pore; other site 882094002520 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094002521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094002522 putative DNA binding site [nucleotide binding]; other site 882094002523 putative Zn2+ binding site [ion binding]; other site 882094002524 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882094002525 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 882094002526 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094002527 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882094002528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094002529 motif II; other site 882094002530 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882094002531 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002532 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002533 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002534 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002535 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002536 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002537 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094002538 Predicted membrane protein [Function unknown]; Region: COG3326 882094002539 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 882094002540 homotrimer interaction site [polypeptide binding]; other site 882094002541 putative active site [active] 882094002542 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882094002543 substrate binding site [chemical binding]; other site 882094002544 zinc-binding site [ion binding]; other site 882094002545 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882094002546 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882094002547 GIY-YIG motif/motif A; other site 882094002548 active site 882094002549 catalytic site [active] 882094002550 putative DNA binding site [nucleotide binding]; other site 882094002551 metal binding site [ion binding]; metal-binding site 882094002552 UvrB/uvrC motif; Region: UVR; pfam02151 882094002553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882094002554 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882094002555 substrate binding pocket [chemical binding]; other site 882094002556 membrane-bound complex binding site; other site 882094002557 hinge residues; other site 882094002558 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882094002559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002560 dimer interface [polypeptide binding]; other site 882094002561 conserved gate region; other site 882094002562 putative PBP binding loops; other site 882094002563 ABC-ATPase subunit interface; other site 882094002564 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882094002565 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882094002566 Walker A/P-loop; other site 882094002567 ATP binding site [chemical binding]; other site 882094002568 Q-loop/lid; other site 882094002569 ABC transporter signature motif; other site 882094002570 Walker B; other site 882094002571 D-loop; other site 882094002572 H-loop/switch region; other site 882094002573 amidase; Provisional; Region: PRK11910 882094002574 Amidase; Region: Amidase; cl11426 882094002575 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094002576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094002577 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882094002578 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 882094002579 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 882094002580 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 882094002581 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 882094002582 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 882094002583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882094002584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882094002585 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 882094002586 Esterase/lipase [General function prediction only]; Region: COG1647 882094002587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094002588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094002589 DNA binding site [nucleotide binding] 882094002590 domain linker motif; other site 882094002591 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 882094002592 putative dimerization interface [polypeptide binding]; other site 882094002593 putative ligand binding site [chemical binding]; other site 882094002594 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882094002595 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094002596 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 882094002597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002598 dimer interface [polypeptide binding]; other site 882094002599 conserved gate region; other site 882094002600 putative PBP binding loops; other site 882094002601 ABC-ATPase subunit interface; other site 882094002602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094002603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094002604 dimer interface [polypeptide binding]; other site 882094002605 conserved gate region; other site 882094002606 ABC-ATPase subunit interface; other site 882094002607 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882094002608 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882094002609 Ca binding site [ion binding]; other site 882094002610 active site 882094002611 catalytic site [active] 882094002612 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 882094002613 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 882094002614 active site 882094002615 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882094002616 active site 882094002617 substrate binding site [chemical binding]; other site 882094002618 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882094002619 metal binding site [ion binding]; metal-binding site 882094002620 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882094002621 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882094002622 ATP binding site [chemical binding]; other site 882094002623 Mg++ binding site [ion binding]; other site 882094002624 motif III; other site 882094002625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094002626 nucleotide binding region [chemical binding]; other site 882094002627 ATP-binding site [chemical binding]; other site 882094002628 Predicted membrane protein [Function unknown]; Region: COG4708 882094002629 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 882094002630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4367 882094002631 Predicted transcriptional regulators [Transcription]; Region: COG1733 882094002632 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882094002633 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 882094002634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002635 putative substrate translocation pore; other site 882094002636 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094002637 PRD domain; Region: PRD; pfam00874 882094002638 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094002639 active site 882094002640 P-loop; other site 882094002641 phosphorylation site [posttranslational modification] 882094002642 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094002643 active site 882094002644 phosphorylation site [posttranslational modification] 882094002645 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094002646 methionine cluster; other site 882094002647 active site 882094002648 phosphorylation site [posttranslational modification] 882094002649 metal binding site [ion binding]; metal-binding site 882094002650 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094002651 active site 882094002652 P-loop; other site 882094002653 phosphorylation site [posttranslational modification] 882094002654 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094002655 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094002656 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882094002657 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882094002658 active site 882094002659 trimer interface [polypeptide binding]; other site 882094002660 allosteric site; other site 882094002661 active site lid [active] 882094002662 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882094002663 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094002664 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094002665 active site 882094002666 catalytic tetrad [active] 882094002667 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882094002668 Collagen binding domain; Region: Collagen_bind; pfam05737 882094002669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094002670 Uncharacterized conserved protein [Function unknown]; Region: COG3402 882094002671 Predicted membrane protein [Function unknown]; Region: COG3428 882094002672 Bacterial PH domain; Region: DUF304; pfam03703 882094002673 Bacterial PH domain; Region: DUF304; pfam03703 882094002674 Bacterial PH domain; Region: DUF304; pfam03703 882094002675 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 882094002676 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 882094002677 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 882094002678 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 882094002679 active site 882094002680 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882094002681 dimer interface [polypeptide binding]; other site 882094002682 substrate binding site [chemical binding]; other site 882094002683 catalytic residues [active] 882094002684 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 882094002685 PemK-like protein; Region: PemK; pfam02452 882094002686 Rsbr N terminal; Region: Rsbr_N; pfam08678 882094002687 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094002688 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094002689 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882094002690 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 882094002691 ATP binding site [chemical binding]; other site 882094002692 Mg2+ binding site [ion binding]; other site 882094002693 G-X-G motif; other site 882094002694 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 882094002695 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 882094002696 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 882094002697 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 882094002698 anti sigma factor interaction site; other site 882094002699 regulatory phosphorylation site [posttranslational modification]; other site 882094002700 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 882094002701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094002702 ATP binding site [chemical binding]; other site 882094002703 Mg2+ binding site [ion binding]; other site 882094002704 G-X-G motif; other site 882094002705 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 882094002706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882094002707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882094002708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882094002709 DNA binding residues [nucleotide binding] 882094002710 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 882094002711 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 882094002712 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 882094002713 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882094002714 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 882094002715 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 882094002716 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 882094002717 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 882094002718 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 882094002719 RNA binding site [nucleotide binding]; other site 882094002720 hypothetical protein; Provisional; Region: PRK04351 882094002721 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 882094002722 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 882094002723 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 882094002724 Uncharacterized conserved protein [Function unknown]; Region: COG5646 882094002725 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094002726 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094002727 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094002728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002729 DNA-binding site [nucleotide binding]; DNA binding site 882094002730 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882094002731 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882094002732 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882094002733 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 882094002734 glutathione reductase; Validated; Region: PRK06116 882094002735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094002736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094002737 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882094002738 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094002739 catalytic core [active] 882094002740 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882094002741 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882094002742 Predicted transcriptional regulators [Transcription]; Region: COG1725 882094002743 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002744 DNA-binding site [nucleotide binding]; DNA binding site 882094002745 Predicted membrane protein [General function prediction only]; Region: COG4194 882094002746 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882094002747 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882094002748 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 882094002749 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 882094002750 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 882094002751 tetramerization interface [polypeptide binding]; other site 882094002752 NAD(P) binding site [chemical binding]; other site 882094002753 catalytic residues [active] 882094002754 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 882094002755 active site 882094002756 P-loop; other site 882094002757 phosphorylation site [posttranslational modification] 882094002758 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094002759 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094002760 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094002761 methionine cluster; other site 882094002762 active site 882094002763 phosphorylation site [posttranslational modification] 882094002764 metal binding site [ion binding]; metal-binding site 882094002765 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094002766 beta-galactosidase; Region: BGL; TIGR03356 882094002767 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094002768 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094002769 PRD domain; Region: PRD; pfam00874 882094002770 PRD domain; Region: PRD; pfam00874 882094002771 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094002772 active site 882094002773 phosphorylation site [posttranslational modification] 882094002774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094002775 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882094002776 ABC transporter; Region: ABC_tran_2; pfam12848 882094002777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094002778 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 882094002779 Predicted permeases [General function prediction only]; Region: COG0701 882094002780 Predicted membrane protein [Function unknown]; Region: COG3689 882094002781 pantothenate kinase; Provisional; Region: PRK05439 882094002782 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 882094002783 ATP-binding site [chemical binding]; other site 882094002784 CoA-binding site [chemical binding]; other site 882094002785 Mg2+-binding site [ion binding]; other site 882094002786 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 882094002787 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094002788 Walker A/P-loop; other site 882094002789 ATP binding site [chemical binding]; other site 882094002790 Q-loop/lid; other site 882094002791 ABC transporter signature motif; other site 882094002792 Walker B; other site 882094002793 D-loop; other site 882094002794 H-loop/switch region; other site 882094002795 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882094002796 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882094002797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094002798 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094002799 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 882094002800 Domain of unknown function (DUF373); Region: DUF373; cl12079 882094002801 Sulfatase; Region: Sulfatase; pfam00884 882094002802 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 882094002803 active site 882094002804 DNA binding site [nucleotide binding] 882094002805 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 882094002806 active site 882094002807 catalytic site [active] 882094002808 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 882094002809 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882094002810 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 882094002811 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 882094002812 Uncharacterized conserved protein [Function unknown]; Region: COG0398 882094002813 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882094002814 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 882094002815 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 882094002816 epoxyqueuosine reductase; Region: TIGR00276 882094002817 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 882094002818 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 882094002819 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882094002820 dimer interface [polypeptide binding]; other site 882094002821 FMN binding site [chemical binding]; other site 882094002822 NADPH bind site [chemical binding]; other site 882094002823 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882094002824 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882094002825 active site 882094002826 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 882094002827 HSP90 family protein; Provisional; Region: PRK14083 882094002828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094002829 ATP binding site [chemical binding]; other site 882094002830 Mg2+ binding site [ion binding]; other site 882094002831 G-X-G motif; other site 882094002832 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 882094002833 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 882094002834 dimerization interface [polypeptide binding]; other site 882094002835 DPS ferroxidase diiron center [ion binding]; other site 882094002836 ion pore; other site 882094002837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 882094002838 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 882094002839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094002840 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 882094002841 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 882094002842 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 882094002843 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002844 putative substrate translocation pore; other site 882094002845 Transcriptional regulators [Transcription]; Region: FadR; COG2186 882094002846 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002847 DNA-binding site [nucleotide binding]; DNA binding site 882094002848 FCD domain; Region: FCD; pfam07729 882094002849 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882094002850 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882094002851 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882094002852 PGAP1-like protein; Region: PGAP1; pfam07819 882094002853 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 882094002854 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 882094002855 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 882094002856 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 882094002857 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882094002858 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882094002859 active site 882094002860 dimer interface [polypeptide binding]; other site 882094002861 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882094002862 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882094002863 active site 882094002864 trimer interface [polypeptide binding]; other site 882094002865 allosteric site; other site 882094002866 active site lid [active] 882094002867 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882094002868 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094002869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094002870 DNA-binding site [nucleotide binding]; DNA binding site 882094002871 UTRA domain; Region: UTRA; pfam07702 882094002872 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882094002873 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882094002874 Mg++ binding site [ion binding]; other site 882094002875 putative catalytic motif [active] 882094002876 substrate binding site [chemical binding]; other site 882094002877 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882094002878 Peptidase family U32; Region: Peptidase_U32; pfam01136 882094002879 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 882094002880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882094002881 Peptidase family U32; Region: Peptidase_U32; pfam01136 882094002882 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 882094002883 heat shock protein HtpX; Provisional; Region: PRK04897 882094002884 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 882094002885 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 882094002886 catalytic residues [active] 882094002887 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 882094002888 putative active site [active] 882094002889 putative metal binding residues [ion binding]; other site 882094002890 signature motif; other site 882094002891 putative triphosphate binding site [ion binding]; other site 882094002892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094002893 TPR motif; other site 882094002894 binding surface 882094002895 Tetratrico peptide repeat; Region: TPR_5; pfam12688 882094002896 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882094002897 synthetase active site [active] 882094002898 NTP binding site [chemical binding]; other site 882094002899 metal binding site [ion binding]; metal-binding site 882094002900 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 882094002901 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882094002902 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882094002903 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882094002904 active site 882094002905 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 882094002906 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 882094002907 NAD binding site [chemical binding]; other site 882094002908 homotetramer interface [polypeptide binding]; other site 882094002909 homodimer interface [polypeptide binding]; other site 882094002910 substrate binding site [chemical binding]; other site 882094002911 active site 882094002912 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 882094002913 DltD N-terminal region; Region: DltD_N; pfam04915 882094002914 DltD central region; Region: DltD_M; pfam04918 882094002915 DltD C-terminal region; Region: DltD_C; pfam04914 882094002916 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 882094002917 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 882094002918 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 882094002919 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 882094002920 acyl-activating enzyme (AAE) consensus motif; other site 882094002921 AMP binding site [chemical binding]; other site 882094002922 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 882094002923 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 882094002924 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094002925 active site 882094002926 dimer interface [polypeptide binding]; other site 882094002927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094002928 Coenzyme A binding pocket [chemical binding]; other site 882094002929 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 882094002930 Putative esterase; Region: Esterase; pfam00756 882094002931 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 882094002932 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 882094002933 homodimer interface [polypeptide binding]; other site 882094002934 substrate-cofactor binding pocket; other site 882094002935 catalytic residue [active] 882094002936 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882094002937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094002938 Walker A/P-loop; other site 882094002939 ATP binding site [chemical binding]; other site 882094002940 Q-loop/lid; other site 882094002941 ABC transporter signature motif; other site 882094002942 Walker B; other site 882094002943 D-loop; other site 882094002944 H-loop/switch region; other site 882094002945 ABC-2 type transporter; Region: ABC2_membrane; cl17235 882094002946 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 882094002947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094002948 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094002949 putative substrate translocation pore; other site 882094002950 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882094002951 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 882094002952 putative oligomer interface [polypeptide binding]; other site 882094002953 putative active site [active] 882094002954 metal binding site [ion binding]; metal-binding site 882094002955 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 882094002956 catalytic residues [active] 882094002957 dimer interface [polypeptide binding]; other site 882094002958 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 882094002959 LytTr DNA-binding domain; Region: LytTR; pfam04397 882094002960 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094002961 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094002962 Walker A/P-loop; other site 882094002963 ATP binding site [chemical binding]; other site 882094002964 Q-loop/lid; other site 882094002965 ABC transporter signature motif; other site 882094002966 Walker B; other site 882094002967 D-loop; other site 882094002968 H-loop/switch region; other site 882094002969 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 882094002970 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 882094002971 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882094002972 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 882094002973 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 882094002974 G1 box; other site 882094002975 putative GEF interaction site [polypeptide binding]; other site 882094002976 GTP/Mg2+ binding site [chemical binding]; other site 882094002977 Switch I region; other site 882094002978 G2 box; other site 882094002979 G3 box; other site 882094002980 Switch II region; other site 882094002981 G4 box; other site 882094002982 G5 box; other site 882094002983 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 882094002984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094002985 MarR family; Region: MarR_2; cl17246 882094002986 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882094002987 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882094002988 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882094002989 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 882094002990 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 882094002991 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 882094002992 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 882094002993 Acyltransferase family; Region: Acyl_transf_3; pfam01757 882094002994 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 882094002995 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882094002996 DNA binding site [nucleotide binding] 882094002997 active site 882094002998 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 882094002999 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094003000 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 882094003001 Walker A motif; other site 882094003002 ATP binding site [chemical binding]; other site 882094003003 Walker B motif; other site 882094003004 arginine finger; other site 882094003005 UvrB/uvrC motif; Region: UVR; pfam02151 882094003006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094003007 Walker A motif; other site 882094003008 ATP binding site [chemical binding]; other site 882094003009 Walker B motif; other site 882094003010 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882094003011 CAAX protease self-immunity; Region: Abi; pfam02517 882094003012 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 882094003013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882094003014 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 882094003015 nucleotide binding site [chemical binding]; other site 882094003016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 882094003017 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 882094003018 dimerization domain swap beta strand [polypeptide binding]; other site 882094003019 regulatory protein interface [polypeptide binding]; other site 882094003020 active site 882094003021 regulatory phosphorylation site [posttranslational modification]; other site 882094003022 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 882094003023 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 882094003024 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882094003025 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882094003026 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882094003027 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882094003028 putative active site [active] 882094003029 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 882094003030 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882094003031 aminotransferase A; Validated; Region: PRK07683 882094003032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094003033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094003034 homodimer interface [polypeptide binding]; other site 882094003035 catalytic residue [active] 882094003036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 882094003037 FOG: CBS domain [General function prediction only]; Region: COG0517 882094003038 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 882094003039 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094003040 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094003041 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882094003042 dimerization interface [polypeptide binding]; other site 882094003043 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 882094003044 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 882094003045 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882094003046 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882094003047 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882094003048 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 882094003049 metal binding site [ion binding]; metal-binding site 882094003050 putative dimer interface [polypeptide binding]; other site 882094003051 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 882094003052 Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264 882094003053 Mechanosensitive ion channel; Region: MS_channel; pfam00924 882094003054 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 882094003055 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003056 Walker A/P-loop; other site 882094003057 ATP binding site [chemical binding]; other site 882094003058 Q-loop/lid; other site 882094003059 ABC transporter signature motif; other site 882094003060 Walker B; other site 882094003061 D-loop; other site 882094003062 H-loop/switch region; other site 882094003063 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882094003064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094003065 dimer interface [polypeptide binding]; other site 882094003066 conserved gate region; other site 882094003067 putative PBP binding loops; other site 882094003068 ABC-ATPase subunit interface; other site 882094003069 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 882094003070 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882094003071 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882094003072 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 882094003073 HPr interaction site; other site 882094003074 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882094003075 active site 882094003076 phosphorylation site [posttranslational modification] 882094003077 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 882094003078 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 882094003079 S1 domain; Region: S1_2; pfam13509 882094003080 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 882094003081 RNA binding site [nucleotide binding]; other site 882094003082 Predicted membrane protein [Function unknown]; Region: COG4758 882094003083 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 882094003084 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 882094003085 Histidine kinase; Region: HisKA_3; pfam07730 882094003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094003087 ATP binding site [chemical binding]; other site 882094003088 Mg2+ binding site [ion binding]; other site 882094003089 G-X-G motif; other site 882094003090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882094003091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094003092 active site 882094003093 phosphorylation site [posttranslational modification] 882094003094 intermolecular recognition site; other site 882094003095 dimerization interface [polypeptide binding]; other site 882094003096 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882094003097 DNA binding residues [nucleotide binding] 882094003098 dimerization interface [polypeptide binding]; other site 882094003099 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 882094003100 TrkA-N domain; Region: TrkA_N; pfam02254 882094003101 TrkA-C domain; Region: TrkA_C; pfam02080 882094003102 Predicted membrane protein [Function unknown]; Region: COG1289 882094003103 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 882094003104 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 882094003105 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882094003106 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882094003107 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882094003108 hypothetical protein; Provisional; Region: PRK13667 882094003109 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094003110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094003111 active site 882094003112 motif I; other site 882094003113 motif II; other site 882094003114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094003115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094003116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094003117 DNA binding site [nucleotide binding] 882094003118 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882094003119 ligand binding site [chemical binding]; other site 882094003120 dimerization interface [polypeptide binding]; other site 882094003121 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 882094003122 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882094003123 trimer interface [polypeptide binding]; other site 882094003124 substrate binding site [chemical binding]; other site 882094003125 Mn binding site [ion binding]; other site 882094003126 transketolase; Reviewed; Region: PRK05899 882094003127 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882094003128 TPP-binding site [chemical binding]; other site 882094003129 dimer interface [polypeptide binding]; other site 882094003130 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 882094003131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882094003132 PYR/PP interface [polypeptide binding]; other site 882094003133 dimer interface [polypeptide binding]; other site 882094003134 TPP binding site [chemical binding]; other site 882094003135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094003136 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 882094003137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 882094003138 nucleotide binding site [chemical binding]; other site 882094003139 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882094003140 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882094003141 active site turn [active] 882094003142 phosphorylation site [posttranslational modification] 882094003143 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882094003144 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882094003145 HPr interaction site; other site 882094003146 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882094003147 active site 882094003148 phosphorylation site [posttranslational modification] 882094003149 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 882094003150 Uncharacterized integral membrane protein [Function unknown]; Region: COG3739 882094003151 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 882094003152 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 882094003153 GTP binding site; other site 882094003154 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 882094003155 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882094003156 Walker A/P-loop; other site 882094003157 ATP binding site [chemical binding]; other site 882094003158 Q-loop/lid; other site 882094003159 ABC transporter signature motif; other site 882094003160 Walker B; other site 882094003161 D-loop; other site 882094003162 H-loop/switch region; other site 882094003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094003164 dimer interface [polypeptide binding]; other site 882094003165 conserved gate region; other site 882094003166 putative PBP binding loops; other site 882094003167 ABC-ATPase subunit interface; other site 882094003168 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 882094003169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 882094003170 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 882094003171 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 882094003172 dimer interface [polypeptide binding]; other site 882094003173 putative functional site; other site 882094003174 putative MPT binding site; other site 882094003175 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 882094003176 Walker A motif; other site 882094003177 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 882094003178 MoaE homodimer interface [polypeptide binding]; other site 882094003179 MoaD interaction [polypeptide binding]; other site 882094003180 active site residues [active] 882094003181 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 882094003182 MoaE interaction surface [polypeptide binding]; other site 882094003183 MoeB interaction surface [polypeptide binding]; other site 882094003184 thiocarboxylated glycine; other site 882094003185 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 882094003186 trimer interface [polypeptide binding]; other site 882094003187 dimer interface [polypeptide binding]; other site 882094003188 putative active site [active] 882094003189 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 882094003190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882094003191 FeS/SAM binding site; other site 882094003192 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 882094003193 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 882094003194 MPT binding site; other site 882094003195 trimer interface [polypeptide binding]; other site 882094003196 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 882094003197 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 882094003198 ATP binding site [chemical binding]; other site 882094003199 substrate interface [chemical binding]; other site 882094003200 Flavin Reductases; Region: FlaRed; cl00801 882094003201 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 882094003202 active site 882094003203 catalytic residues [active] 882094003204 metal binding site [ion binding]; metal-binding site 882094003205 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 882094003206 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882094003207 TPP-binding site [chemical binding]; other site 882094003208 tetramer interface [polypeptide binding]; other site 882094003209 heterodimer interface [polypeptide binding]; other site 882094003210 phosphorylation loop region [posttranslational modification] 882094003211 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882094003212 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882094003213 alpha subunit interface [polypeptide binding]; other site 882094003214 TPP binding site [chemical binding]; other site 882094003215 heterodimer interface [polypeptide binding]; other site 882094003216 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094003217 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 882094003218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882094003219 E3 interaction surface; other site 882094003220 lipoyl attachment site [posttranslational modification]; other site 882094003221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882094003222 E3 interaction surface; other site 882094003223 lipoyl attachment site [posttranslational modification]; other site 882094003224 e3 binding domain; Region: E3_binding; pfam02817 882094003225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882094003226 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 882094003227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882094003228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094003229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882094003230 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 882094003231 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 882094003232 NAD(P) binding site [chemical binding]; other site 882094003233 LDH/MDH dimer interface [polypeptide binding]; other site 882094003234 substrate binding site [chemical binding]; other site 882094003235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 882094003236 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 882094003237 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 882094003238 catalytic residues [active] 882094003239 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 882094003240 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 882094003241 Cl binding site [ion binding]; other site 882094003242 oligomer interface [polypeptide binding]; other site 882094003243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 882094003244 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 882094003245 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 882094003246 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 882094003247 active site 882094003248 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 882094003249 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 882094003250 G1 box; other site 882094003251 putative GEF interaction site [polypeptide binding]; other site 882094003252 GTP/Mg2+ binding site [chemical binding]; other site 882094003253 Switch I region; other site 882094003254 G2 box; other site 882094003255 G3 box; other site 882094003256 Switch II region; other site 882094003257 G4 box; other site 882094003258 G5 box; other site 882094003259 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 882094003260 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 882094003261 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4896 882094003262 hypothetical protein; Provisional; Region: PRK13666 882094003263 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882094003264 pyruvate carboxylase; Reviewed; Region: PRK12999 882094003265 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882094003266 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882094003267 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882094003268 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 882094003269 active site 882094003270 catalytic residues [active] 882094003271 metal binding site [ion binding]; metal-binding site 882094003272 homodimer binding site [polypeptide binding]; other site 882094003273 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882094003274 carboxyltransferase (CT) interaction site; other site 882094003275 biotinylation site [posttranslational modification]; other site 882094003276 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 882094003277 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882094003278 putative binding site residues; other site 882094003279 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 882094003280 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 882094003281 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 882094003282 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 882094003283 Walker A/P-loop; other site 882094003284 ATP binding site [chemical binding]; other site 882094003285 Q-loop/lid; other site 882094003286 ABC transporter signature motif; other site 882094003287 Walker B; other site 882094003288 D-loop; other site 882094003289 H-loop/switch region; other site 882094003290 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094003291 SH3-like domain; Region: SH3_8; pfam13457 882094003292 SH3-like domain; Region: SH3_8; pfam13457 882094003293 SH3-like domain; Region: SH3_8; pfam13457 882094003294 SH3-like domain; Region: SH3_8; pfam13457 882094003295 SH3-like domain; Region: SH3_8; pfam13457 882094003296 SH3-like domain; Region: SH3_8; pfam13457 882094003297 SH3-like domain; Region: SH3_8; pfam13457 882094003298 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 882094003299 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 882094003300 Ligand binding site; other site 882094003301 Putative Catalytic site; other site 882094003302 DXD motif; other site 882094003303 conserved hypothetical integral membrane protein; Region: TIGR03766 882094003304 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 882094003305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882094003306 active site 882094003307 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882094003308 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882094003309 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 882094003310 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 882094003311 active site 882094003312 tetramer interface; other site 882094003313 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 882094003314 substrate binding site; other site 882094003315 dimer interface; other site 882094003316 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 882094003317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882094003318 putative NAD(P) binding site [chemical binding]; other site 882094003319 putative catalytic Zn binding site [ion binding]; other site 882094003320 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 882094003321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 882094003322 active site 882094003323 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882094003324 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 882094003325 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 882094003326 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 882094003327 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 882094003328 active site 882094003329 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 882094003330 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 882094003331 active site 882094003332 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 882094003333 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 882094003334 homodimer interface [polypeptide binding]; other site 882094003335 NAD binding pocket [chemical binding]; other site 882094003336 ATP binding pocket [chemical binding]; other site 882094003337 Mg binding site [ion binding]; other site 882094003338 active-site loop [active] 882094003339 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882094003340 Phosphotransferase system cellobiose-specific component IIB [Carbohydrate transport and metabolism]; Region: CelA; COG1440 882094003341 active site 882094003342 P-loop; other site 882094003343 phosphorylation site [posttranslational modification] 882094003344 GMP synthase; Reviewed; Region: guaA; PRK00074 882094003345 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 882094003346 AMP/PPi binding site [chemical binding]; other site 882094003347 candidate oxyanion hole; other site 882094003348 catalytic triad [active] 882094003349 potential glutamine specificity residues [chemical binding]; other site 882094003350 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 882094003351 ATP Binding subdomain [chemical binding]; other site 882094003352 Dimerization subdomain; other site 882094003353 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882094003354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094003355 active site 882094003356 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882094003357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003358 Walker A/P-loop; other site 882094003359 ATP binding site [chemical binding]; other site 882094003360 Q-loop/lid; other site 882094003361 ABC transporter signature motif; other site 882094003362 Walker B; other site 882094003363 D-loop; other site 882094003364 H-loop/switch region; other site 882094003365 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 882094003366 putative FMN binding site [chemical binding]; other site 882094003367 NADPH bind site [chemical binding]; other site 882094003368 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 882094003369 YcaO-like family; Region: YcaO; pfam02624 882094003370 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 882094003371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003372 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094003373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003374 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882094003375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094003376 active site 882094003377 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 882094003378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003379 Walker A/P-loop; other site 882094003380 ATP binding site [chemical binding]; other site 882094003381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003382 Q-loop/lid; other site 882094003383 ABC transporter signature motif; other site 882094003384 Walker B; other site 882094003385 D-loop; other site 882094003386 H-loop/switch region; other site 882094003387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882094003388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882094003389 Coenzyme A binding pocket [chemical binding]; other site 882094003390 MepB protein; Region: MepB; cl01985 882094003391 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 882094003392 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094003393 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094003394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094003395 Coenzyme A binding pocket [chemical binding]; other site 882094003396 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094003397 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 882094003398 DNA binding residues [nucleotide binding] 882094003399 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882094003400 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094003401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003402 Walker A/P-loop; other site 882094003403 ATP binding site [chemical binding]; other site 882094003404 Q-loop/lid; other site 882094003405 ABC transporter signature motif; other site 882094003406 Walker B; other site 882094003407 D-loop; other site 882094003408 H-loop/switch region; other site 882094003409 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094003410 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094003411 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003412 Walker A/P-loop; other site 882094003413 ATP binding site [chemical binding]; other site 882094003414 Q-loop/lid; other site 882094003415 ABC transporter signature motif; other site 882094003416 Walker B; other site 882094003417 D-loop; other site 882094003418 H-loop/switch region; other site 882094003419 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882094003420 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094003421 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094003422 DNA binding residues [nucleotide binding] 882094003423 putative dimer interface [polypeptide binding]; other site 882094003424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882094003425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882094003426 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 882094003427 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094003428 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882094003429 LRR adjacent; Region: LRR_adjacent; pfam08191 882094003430 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094003431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 882094003432 Clp protease; Region: CLP_protease; pfam00574 882094003433 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882094003434 oligomer interface [polypeptide binding]; other site 882094003435 active site residues [active] 882094003436 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882094003437 dimer interface [polypeptide binding]; other site 882094003438 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094003439 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 882094003440 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 882094003441 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 882094003442 SLBB domain; Region: SLBB; pfam10531 882094003443 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 882094003444 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 882094003445 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003446 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882094003447 putative hexamer interface [polypeptide binding]; other site 882094003448 putative hexagonal pore; other site 882094003449 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882094003450 putative hexamer interface [polypeptide binding]; other site 882094003451 putative hexagonal pore; other site 882094003452 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 882094003453 putative hexamer interface [polypeptide binding]; other site 882094003454 putative hexagonal pore; other site 882094003455 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 882094003456 G1 box; other site 882094003457 GTP/Mg2+ binding site [chemical binding]; other site 882094003458 G2 box; other site 882094003459 Switch I region; other site 882094003460 G3 box; other site 882094003461 Switch II region; other site 882094003462 G4 box; other site 882094003463 G5 box; other site 882094003464 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 882094003465 homotrimer interface [polypeptide binding]; other site 882094003466 Walker A motif; other site 882094003467 GTP binding site [chemical binding]; other site 882094003468 Walker B motif; other site 882094003469 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 882094003470 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094003471 catalytic core [active] 882094003472 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 882094003473 Sensory domain found in PocR; Region: PocR; pfam10114 882094003474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003475 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094003476 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003477 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003478 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882094003479 Hexamer interface [polypeptide binding]; other site 882094003480 Hexagonal pore residue; other site 882094003481 propanediol utilization protein PduB; Provisional; Region: PRK15415 882094003482 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 882094003483 putative hexamer interface [polypeptide binding]; other site 882094003484 putative hexagonal pore; other site 882094003485 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 882094003486 putative hexamer interface [polypeptide binding]; other site 882094003487 putative hexagonal pore; other site 882094003488 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 882094003489 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 882094003490 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 882094003491 alpha-beta subunit interface [polypeptide binding]; other site 882094003492 alpha-gamma subunit interface [polypeptide binding]; other site 882094003493 active site 882094003494 substrate and K+ binding site; other site 882094003495 K+ binding site [ion binding]; other site 882094003496 cobalamin binding site [chemical binding]; other site 882094003497 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 882094003498 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 882094003499 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 882094003500 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 882094003501 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003502 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 882094003503 putative hexamer interface [polypeptide binding]; other site 882094003504 putative hexagonal pore; other site 882094003505 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003506 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882094003507 Hexamer interface [polypeptide binding]; other site 882094003508 Hexagonal pore residue; other site 882094003509 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882094003510 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882094003511 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882094003512 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 882094003513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094003514 nucleotide binding site [chemical binding]; other site 882094003515 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 882094003516 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882094003517 Hexamer/Pentamer interface [polypeptide binding]; other site 882094003518 central pore; other site 882094003519 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882094003520 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 882094003521 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 882094003522 putative catalytic cysteine [active] 882094003523 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882094003524 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882094003525 putative active site [active] 882094003526 metal binding site [ion binding]; metal-binding site 882094003527 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882094003528 amphipathic channel; other site 882094003529 Asn-Pro-Ala signature motifs; other site 882094003530 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882094003531 propionate/acetate kinase; Provisional; Region: PRK12379 882094003532 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 882094003533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094003534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094003535 homodimer interface [polypeptide binding]; other site 882094003536 catalytic residue [active] 882094003537 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 882094003538 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 882094003539 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 882094003540 putative active site [active] 882094003541 metal binding site [ion binding]; metal-binding site 882094003542 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 882094003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094003544 active site 882094003545 phosphorylation site [posttranslational modification] 882094003546 intermolecular recognition site; other site 882094003547 dimerization interface [polypeptide binding]; other site 882094003548 ANTAR domain; Region: ANTAR; pfam03861 882094003549 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 882094003550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 882094003551 Histidine kinase; Region: HisKA_2; pfam07568 882094003552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094003553 ATP binding site [chemical binding]; other site 882094003554 Mg2+ binding site [ion binding]; other site 882094003555 G-X-G motif; other site 882094003556 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 882094003557 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 882094003558 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 882094003559 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 882094003560 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 882094003561 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 882094003562 putative hexamer interface [polypeptide binding]; other site 882094003563 putative hexagonal pore; other site 882094003564 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 882094003565 putative hexamer interface [polypeptide binding]; other site 882094003566 putative hexagonal pore; other site 882094003567 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003568 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 882094003569 Hexamer interface [polypeptide binding]; other site 882094003570 Hexagonal pore residue; other site 882094003571 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882094003572 putative catalytic cysteine [active] 882094003573 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 882094003574 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 882094003575 Hexamer interface [polypeptide binding]; other site 882094003576 Putative hexagonal pore residue; other site 882094003577 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 882094003578 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 882094003579 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882094003580 Propanediol utilisation protein PduL; Region: PduL; pfam06130 882094003581 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 882094003582 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 882094003583 Hexamer/Pentamer interface [polypeptide binding]; other site 882094003584 central pore; other site 882094003585 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 882094003586 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 882094003587 putative hexamer interface [polypeptide binding]; other site 882094003588 putative hexagonal pore; other site 882094003589 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 882094003590 putative hexamer interface [polypeptide binding]; other site 882094003591 putative hexagonal pore; other site 882094003592 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 882094003593 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 882094003594 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 882094003595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094003597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094003598 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 882094003599 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882094003600 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 882094003601 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 882094003602 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 882094003603 catalytic triad [active] 882094003604 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 882094003605 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 882094003606 Precorrin-8X methylmutase; Region: CbiC; pfam02570 882094003607 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 882094003608 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 882094003609 active site 882094003610 putative homodimer interface [polypeptide binding]; other site 882094003611 SAM binding site [chemical binding]; other site 882094003612 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 882094003613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094003614 S-adenosylmethionine binding site [chemical binding]; other site 882094003615 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 882094003616 active site 882094003617 SAM binding site [chemical binding]; other site 882094003618 homodimer interface [polypeptide binding]; other site 882094003619 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 882094003620 active site 882094003621 SAM binding site [chemical binding]; other site 882094003622 homodimer interface [polypeptide binding]; other site 882094003623 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 882094003624 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 882094003625 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 882094003626 active site 882094003627 SAM binding site [chemical binding]; other site 882094003628 homodimer interface [polypeptide binding]; other site 882094003629 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 882094003630 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882094003631 active site 882094003632 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 882094003633 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 882094003634 active site 882094003635 C-terminal domain interface [polypeptide binding]; other site 882094003636 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 882094003637 active site 882094003638 N-terminal domain interface [polypeptide binding]; other site 882094003639 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 882094003640 active site 882094003641 SAM binding site [chemical binding]; other site 882094003642 homodimer interface [polypeptide binding]; other site 882094003643 cobalt transport protein CbiM; Validated; Region: PRK08319 882094003644 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 882094003645 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 882094003646 cobalt transport protein CbiQ; Provisional; Region: PRK15485 882094003647 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 882094003648 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882094003649 Walker A/P-loop; other site 882094003650 ATP binding site [chemical binding]; other site 882094003651 Q-loop/lid; other site 882094003652 ABC transporter signature motif; other site 882094003653 Walker B; other site 882094003654 D-loop; other site 882094003655 H-loop/switch region; other site 882094003656 cobyric acid synthase; Provisional; Region: PRK00784 882094003657 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882094003658 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882094003659 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 882094003660 catalytic triad [active] 882094003661 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 882094003662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882094003663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 882094003664 AAA domain; Region: AAA_17; cl17253 882094003665 Predicted transcriptional regulators [Transcription]; Region: COG1695 882094003666 Transcriptional regulator PadR-like family; Region: PadR; cl17335 882094003667 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 882094003668 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094003669 SH3-like domain; Region: SH3_8; pfam13457 882094003670 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094003671 SH3-like domain; Region: SH3_8; pfam13457 882094003672 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882094003673 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882094003674 oligomer interface [polypeptide binding]; other site 882094003675 active site 882094003676 metal binding site [ion binding]; metal-binding site 882094003677 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 882094003678 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 882094003679 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 882094003680 Predicted transcriptional regulators [Transcription]; Region: COG1733 882094003681 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 882094003682 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 882094003683 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 882094003684 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 882094003685 dimer interface [polypeptide binding]; other site 882094003686 motif 1; other site 882094003687 active site 882094003688 motif 2; other site 882094003689 motif 3; other site 882094003690 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 882094003691 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882094003692 putative tRNA-binding site [nucleotide binding]; other site 882094003693 B3/4 domain; Region: B3_4; pfam03483 882094003694 tRNA synthetase B5 domain; Region: B5; smart00874 882094003695 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 882094003696 dimer interface [polypeptide binding]; other site 882094003697 motif 1; other site 882094003698 motif 3; other site 882094003699 motif 2; other site 882094003700 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 882094003701 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094003702 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094003703 Walker A/P-loop; other site 882094003704 ATP binding site [chemical binding]; other site 882094003705 Q-loop/lid; other site 882094003706 ABC transporter signature motif; other site 882094003707 Walker B; other site 882094003708 D-loop; other site 882094003709 H-loop/switch region; other site 882094003710 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094003711 FtsX-like permease family; Region: FtsX; pfam02687 882094003712 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882094003713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094003714 FtsX-like permease family; Region: FtsX; pfam02687 882094003715 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882094003716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094003717 putative DNA binding site [nucleotide binding]; other site 882094003718 putative Zn2+ binding site [ion binding]; other site 882094003719 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 882094003720 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 882094003721 ligand binding site [chemical binding]; other site 882094003722 active site 882094003723 UGI interface [polypeptide binding]; other site 882094003724 catalytic site [active] 882094003725 ribonuclease HIII; Provisional; Region: PRK00996 882094003726 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 882094003727 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 882094003728 RNA/DNA hybrid binding site [nucleotide binding]; other site 882094003729 active site 882094003730 Cell division protein ZapA; Region: ZapA; cl01146 882094003731 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 882094003732 Colicin V production protein; Region: Colicin_V; pfam02674 882094003733 hypothetical protein; Provisional; Region: PRK08609 882094003734 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 882094003735 active site 882094003736 primer binding site [nucleotide binding]; other site 882094003737 NTP binding site [chemical binding]; other site 882094003738 metal binding triad [ion binding]; metal-binding site 882094003739 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 882094003740 active site 882094003741 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 882094003742 MutS domain III; Region: MutS_III; pfam05192 882094003743 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094003744 Walker A/P-loop; other site 882094003745 ATP binding site [chemical binding]; other site 882094003746 Q-loop/lid; other site 882094003747 ABC transporter signature motif; other site 882094003748 Walker B; other site 882094003749 D-loop; other site 882094003750 H-loop/switch region; other site 882094003751 Smr domain; Region: Smr; pfam01713 882094003752 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094003753 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882094003754 catalytic residues [active] 882094003755 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 882094003756 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 882094003757 GIY-YIG motif/motif A; other site 882094003758 active site 882094003759 catalytic site [active] 882094003760 putative DNA binding site [nucleotide binding]; other site 882094003761 metal binding site [ion binding]; metal-binding site 882094003762 UvrB/uvrC motif; Region: UVR; pfam02151 882094003763 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 882094003764 aspartate kinase; Reviewed; Region: PRK06635 882094003765 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 882094003766 putative nucleotide binding site [chemical binding]; other site 882094003767 putative catalytic residues [active] 882094003768 putative Mg ion binding site [ion binding]; other site 882094003769 putative aspartate binding site [chemical binding]; other site 882094003770 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 882094003771 putative allosteric regulatory site; other site 882094003772 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 882094003773 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 882094003774 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 882094003775 ribonuclease PH; Reviewed; Region: rph; PRK00173 882094003776 Ribonuclease PH; Region: RNase_PH_bact; cd11362 882094003777 hexamer interface [polypeptide binding]; other site 882094003778 active site 882094003779 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 882094003780 active site 882094003781 dimerization interface [polypeptide binding]; other site 882094003782 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 882094003783 active site 882094003784 metal binding site [ion binding]; metal-binding site 882094003785 homotetramer interface [polypeptide binding]; other site 882094003786 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882094003787 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 882094003788 LRR adjacent; Region: LRR_adjacent; pfam08191 882094003789 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094003790 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094003791 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094003792 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094003793 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094003794 Uncharacterized conserved protein [Function unknown]; Region: COG5361 882094003795 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 882094003796 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 882094003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 882094003798 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 882094003799 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 882094003800 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882094003801 dimer interface [polypeptide binding]; other site 882094003802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094003803 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094003804 catalytic core [active] 882094003805 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 882094003806 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882094003807 ATP binding site [chemical binding]; other site 882094003808 Mg++ binding site [ion binding]; other site 882094003809 motif III; other site 882094003810 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094003811 nucleotide binding region [chemical binding]; other site 882094003812 ATP-binding site [chemical binding]; other site 882094003813 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 882094003814 RNA binding site [nucleotide binding]; other site 882094003815 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882094003816 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 882094003817 putative active site [active] 882094003818 nucleotide binding site [chemical binding]; other site 882094003819 nudix motif; other site 882094003820 putative metal binding site [ion binding]; other site 882094003821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094003822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094003823 putative substrate translocation pore; other site 882094003824 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094003825 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094003826 ligand binding site [chemical binding]; other site 882094003827 flexible hinge region; other site 882094003828 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094003829 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882094003830 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094003831 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094003832 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 882094003833 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094003834 DNA-binding site [nucleotide binding]; DNA binding site 882094003835 UTRA domain; Region: UTRA; pfam07702 882094003836 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 882094003837 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 882094003838 Ca binding site [ion binding]; other site 882094003839 active site 882094003840 catalytic site [active] 882094003841 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882094003842 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 882094003843 active site turn [active] 882094003844 phosphorylation site [posttranslational modification] 882094003845 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882094003846 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 882094003847 nudix motif; other site 882094003848 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 882094003849 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094003850 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 882094003851 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 882094003852 putative catalytic cysteine [active] 882094003853 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 882094003854 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 882094003855 nucleotide binding site [chemical binding]; other site 882094003856 homotetrameric interface [polypeptide binding]; other site 882094003857 putative phosphate binding site [ion binding]; other site 882094003858 putative allosteric binding site; other site 882094003859 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 882094003860 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 882094003861 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882094003862 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094003863 non-specific DNA binding site [nucleotide binding]; other site 882094003864 salt bridge; other site 882094003865 sequence-specific DNA binding site [nucleotide binding]; other site 882094003866 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094003867 non-specific DNA binding site [nucleotide binding]; other site 882094003868 salt bridge; other site 882094003869 sequence-specific DNA binding site [nucleotide binding]; other site 882094003870 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882094003871 active site 882094003872 trigger factor; Provisional; Region: tig; PRK01490 882094003873 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 882094003874 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 882094003875 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 882094003876 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 882094003877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094003878 Walker A motif; other site 882094003879 ATP binding site [chemical binding]; other site 882094003880 Walker B motif; other site 882094003881 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882094003882 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882094003883 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882094003884 Catalytic site [active] 882094003885 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882094003886 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 882094003887 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882094003888 Catalytic site [active] 882094003889 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 882094003890 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 882094003891 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882094003892 Catalytic site [active] 882094003893 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 882094003894 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 882094003895 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 882094003896 GTP/Mg2+ binding site [chemical binding]; other site 882094003897 G4 box; other site 882094003898 G5 box; other site 882094003899 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 882094003900 G1 box; other site 882094003901 G1 box; other site 882094003902 GTP/Mg2+ binding site [chemical binding]; other site 882094003903 Switch I region; other site 882094003904 G2 box; other site 882094003905 G2 box; other site 882094003906 G3 box; other site 882094003907 G3 box; other site 882094003908 Switch II region; other site 882094003909 Switch II region; other site 882094003910 G5 box; other site 882094003911 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 882094003912 RNA/DNA hybrid binding site [nucleotide binding]; other site 882094003913 active site 882094003914 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 882094003915 DNA protecting protein DprA; Region: dprA; TIGR00732 882094003916 DNA topoisomerase I; Validated; Region: PRK05582 882094003917 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 882094003918 active site 882094003919 interdomain interaction site; other site 882094003920 putative metal-binding site [ion binding]; other site 882094003921 nucleotide binding site [chemical binding]; other site 882094003922 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882094003923 domain I; other site 882094003924 DNA binding groove [nucleotide binding] 882094003925 phosphate binding site [ion binding]; other site 882094003926 domain II; other site 882094003927 domain III; other site 882094003928 nucleotide binding site [chemical binding]; other site 882094003929 catalytic site [active] 882094003930 domain IV; other site 882094003931 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882094003932 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 882094003933 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882094003934 Glucose inhibited division protein A; Region: GIDA; pfam01134 882094003935 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 882094003936 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 882094003937 active site 882094003938 DNA binding site [nucleotide binding] 882094003939 Int/Topo IB signature motif; other site 882094003940 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 882094003941 active site 882094003942 HslU subunit interaction site [polypeptide binding]; other site 882094003943 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 882094003944 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094003945 Walker A motif; other site 882094003946 ATP binding site [chemical binding]; other site 882094003947 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 882094003948 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 882094003949 transcriptional repressor CodY; Validated; Region: PRK04158 882094003950 CodY GAF-like domain; Region: CodY; pfam06018 882094003951 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 882094003952 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 882094003953 active site 882094003954 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 882094003955 active site 882094003956 catalytic residues [active] 882094003957 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 882094003958 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 882094003959 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 882094003960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094003961 Mg2+ binding site [ion binding]; other site 882094003962 G-X-G motif; other site 882094003963 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 882094003964 anchoring element; other site 882094003965 dimer interface [polypeptide binding]; other site 882094003966 ATP binding site [chemical binding]; other site 882094003967 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 882094003968 active site 882094003969 putative metal-binding site [ion binding]; other site 882094003970 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 882094003971 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 882094003972 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 882094003973 CAP-like domain; other site 882094003974 active site 882094003975 primary dimer interface [polypeptide binding]; other site 882094003976 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 882094003977 S-ribosylhomocysteinase; Provisional; Region: PRK02260 882094003978 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094003979 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 882094003980 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 882094003981 catalytic triad [active] 882094003982 catalytic triad [active] 882094003983 oxyanion hole [active] 882094003984 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 882094003985 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 882094003986 active site 882094003987 catalytic site [active] 882094003988 metal binding site [ion binding]; metal-binding site 882094003989 dimer interface [polypeptide binding]; other site 882094003990 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 882094003991 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 882094003992 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 882094003993 bacterial Hfq-like; Region: Hfq; cd01716 882094003994 hexamer interface [polypeptide binding]; other site 882094003995 Sm1 motif; other site 882094003996 RNA binding site [nucleotide binding]; other site 882094003997 Sm2 motif; other site 882094003998 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 882094003999 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 882094004000 HflX GTPase family; Region: HflX; cd01878 882094004001 G1 box; other site 882094004002 GTP/Mg2+ binding site [chemical binding]; other site 882094004003 Switch I region; other site 882094004004 G2 box; other site 882094004005 G3 box; other site 882094004006 Switch II region; other site 882094004007 G4 box; other site 882094004008 G5 box; other site 882094004009 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 882094004010 Aluminium resistance protein; Region: Alum_res; pfam06838 882094004011 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 882094004012 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882094004013 DNA binding residues [nucleotide binding] 882094004014 putative dimer interface [polypeptide binding]; other site 882094004015 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 882094004016 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 882094004017 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 882094004018 arsenical pump membrane protein; Provisional; Region: PRK15445 882094004019 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 882094004020 transmembrane helices; other site 882094004021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882094004022 LexA repressor; Validated; Region: PRK00215 882094004023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094004024 putative DNA binding site [nucleotide binding]; other site 882094004025 putative Zn2+ binding site [ion binding]; other site 882094004026 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 882094004027 Catalytic site [active] 882094004028 cell division suppressor protein YneA; Provisional; Region: PRK14125 882094004029 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 882094004030 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 882094004031 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882094004032 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882094004033 TPP-binding site [chemical binding]; other site 882094004034 dimer interface [polypeptide binding]; other site 882094004035 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882094004036 PYR/PP interface [polypeptide binding]; other site 882094004037 dimer interface [polypeptide binding]; other site 882094004038 TPP binding site [chemical binding]; other site 882094004039 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094004040 hypothetical protein; Provisional; Region: PRK01844 882094004041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882094004042 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882094004043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094004044 S-adenosylmethionine binding site [chemical binding]; other site 882094004045 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 882094004046 ParB-like nuclease domain; Region: ParBc; pfam02195 882094004047 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 882094004048 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 882094004049 Active Sites [active] 882094004050 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 882094004051 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882094004052 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 882094004053 putative nucleotide binding site [chemical binding]; other site 882094004054 uridine monophosphate binding site [chemical binding]; other site 882094004055 homohexameric interface [polypeptide binding]; other site 882094004056 ribosome recycling factor; Reviewed; Region: frr; PRK00083 882094004057 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 882094004058 hinge region; other site 882094004059 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 882094004060 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 882094004061 catalytic residue [active] 882094004062 putative FPP diphosphate binding site; other site 882094004063 putative FPP binding hydrophobic cleft; other site 882094004064 dimer interface [polypeptide binding]; other site 882094004065 putative IPP diphosphate binding site; other site 882094004066 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 882094004067 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 882094004068 1-deoxy-D-xylulose 5-phosphate reductoisomerase [Lipid metabolism]; Region: Dxr; COG0743 882094004069 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 882094004070 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 882094004071 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 882094004072 RIP metalloprotease RseP; Region: TIGR00054 882094004073 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882094004074 active site 882094004075 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 882094004076 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 882094004077 protein binding site [polypeptide binding]; other site 882094004078 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 882094004079 putative substrate binding region [chemical binding]; other site 882094004080 prolyl-tRNA synthetase; Provisional; Region: PRK09194 882094004081 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 882094004082 dimer interface [polypeptide binding]; other site 882094004083 motif 1; other site 882094004084 active site 882094004085 motif 2; other site 882094004086 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 882094004087 putative deacylase active site [active] 882094004088 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 882094004089 active site 882094004090 motif 3; other site 882094004091 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 882094004092 anticodon binding site; other site 882094004093 DNA polymerase III PolC; Validated; Region: polC; PRK00448 882094004094 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 882094004095 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 882094004096 generic binding surface II; other site 882094004097 generic binding surface I; other site 882094004098 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882094004099 active site 882094004100 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882094004101 active site 882094004102 catalytic site [active] 882094004103 substrate binding site [chemical binding]; other site 882094004104 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 882094004105 ribosome maturation protein RimP; Reviewed; Region: PRK00092 882094004106 Sm and related proteins; Region: Sm_like; cl00259 882094004107 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 882094004108 putative oligomer interface [polypeptide binding]; other site 882094004109 putative RNA binding site [nucleotide binding]; other site 882094004110 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 882094004111 NusA N-terminal domain; Region: NusA_N; pfam08529 882094004112 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 882094004113 RNA binding site [nucleotide binding]; other site 882094004114 homodimer interface [polypeptide binding]; other site 882094004115 NusA-like KH domain; Region: KH_5; pfam13184 882094004116 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 882094004117 G-X-X-G motif; other site 882094004118 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 882094004119 putative RNA binding cleft [nucleotide binding]; other site 882094004120 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 882094004121 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882094004122 translation initiation factor IF-2; Region: IF-2; TIGR00487 882094004123 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 882094004124 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 882094004125 G1 box; other site 882094004126 putative GEF interaction site [polypeptide binding]; other site 882094004127 GTP/Mg2+ binding site [chemical binding]; other site 882094004128 Switch I region; other site 882094004129 G2 box; other site 882094004130 G3 box; other site 882094004131 Switch II region; other site 882094004132 G4 box; other site 882094004133 G5 box; other site 882094004134 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 882094004135 Translation-initiation factor 2; Region: IF-2; pfam11987 882094004136 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 882094004137 Protein of unknown function (DUF503); Region: DUF503; cl00669 882094004138 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 882094004139 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 882094004140 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 882094004141 RNA binding site [nucleotide binding]; other site 882094004142 active site 882094004143 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 882094004144 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 882094004145 active site 882094004146 Riboflavin kinase; Region: Flavokinase; smart00904 882094004147 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 882094004148 16S/18S rRNA binding site [nucleotide binding]; other site 882094004149 S13e-L30e interaction site [polypeptide binding]; other site 882094004150 25S rRNA binding site [nucleotide binding]; other site 882094004151 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 882094004152 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 882094004153 RNase E interface [polypeptide binding]; other site 882094004154 trimer interface [polypeptide binding]; other site 882094004155 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 882094004156 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 882094004157 RNase E interface [polypeptide binding]; other site 882094004158 trimer interface [polypeptide binding]; other site 882094004159 active site 882094004160 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 882094004161 putative nucleic acid binding region [nucleotide binding]; other site 882094004162 G-X-X-G motif; other site 882094004163 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 882094004164 RNA binding site [nucleotide binding]; other site 882094004165 domain interface; other site 882094004166 GTPase RsgA; Reviewed; Region: PRK01889 882094004167 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882094004168 RNA binding site [nucleotide binding]; other site 882094004169 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882094004170 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882094004171 GTP/Mg2+ binding site [chemical binding]; other site 882094004172 G4 box; other site 882094004173 G5 box; other site 882094004174 G1 box; other site 882094004175 Switch I region; other site 882094004176 G2 box; other site 882094004177 G3 box; other site 882094004178 Switch II region; other site 882094004179 YceG-like family; Region: YceG; pfam02618 882094004180 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 882094004181 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 882094004182 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 882094004183 Rhomboid family; Region: Rhomboid; pfam01694 882094004184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094004185 TPR motif; other site 882094004186 TPR repeat; Region: TPR_11; pfam13414 882094004187 binding surface 882094004188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 882094004189 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 882094004190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094004191 nucleotide binding site [chemical binding]; other site 882094004192 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 882094004193 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 882094004194 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 882094004195 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 882094004196 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882094004197 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 882094004198 Type II/IV secretion system protein; Region: T2SE; pfam00437 882094004199 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882094004200 Walker A motif; other site 882094004201 ATP binding site [chemical binding]; other site 882094004202 Walker B motif; other site 882094004203 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 882094004204 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 882094004205 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 882094004206 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 882094004207 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882094004208 tetramer interface [polypeptide binding]; other site 882094004209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094004210 catalytic residue [active] 882094004211 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 882094004212 tetramer interface [polypeptide binding]; other site 882094004213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094004214 catalytic residue [active] 882094004215 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 882094004216 active site residue [active] 882094004217 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 882094004218 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882094004219 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882094004220 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882094004221 active site 882094004222 elongation factor P; Validated; Region: PRK00529 882094004223 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 882094004224 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 882094004225 RNA binding site [nucleotide binding]; other site 882094004226 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 882094004227 RNA binding site [nucleotide binding]; other site 882094004228 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 882094004229 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 882094004230 carboxyltransferase (CT) interaction site; other site 882094004231 biotinylation site [posttranslational modification]; other site 882094004232 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 882094004233 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882094004234 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882094004235 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 882094004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882094004237 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 882094004238 putative RNA binding site [nucleotide binding]; other site 882094004239 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 882094004240 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 882094004241 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 882094004242 homodimer interface [polypeptide binding]; other site 882094004243 NADP binding site [chemical binding]; other site 882094004244 substrate binding site [chemical binding]; other site 882094004245 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 882094004246 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 882094004247 generic binding surface II; other site 882094004248 generic binding surface I; other site 882094004249 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 882094004250 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882094004251 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882094004252 substrate binding pocket [chemical binding]; other site 882094004253 chain length determination region; other site 882094004254 substrate-Mg2+ binding site; other site 882094004255 catalytic residues [active] 882094004256 aspartate-rich region 1; other site 882094004257 active site lid residues [active] 882094004258 aspartate-rich region 2; other site 882094004259 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882094004260 DNA-binding site [nucleotide binding]; DNA binding site 882094004261 RNA-binding motif; other site 882094004262 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 882094004263 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 882094004264 TPP-binding site; other site 882094004265 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882094004266 PYR/PP interface [polypeptide binding]; other site 882094004267 dimer interface [polypeptide binding]; other site 882094004268 TPP binding site [chemical binding]; other site 882094004269 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094004270 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 882094004271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094004272 RNA binding surface [nucleotide binding]; other site 882094004273 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 882094004274 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 882094004275 arginine repressor; Provisional; Region: PRK04280 882094004276 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 882094004277 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 882094004278 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882094004279 Walker A/P-loop; other site 882094004280 ATP binding site [chemical binding]; other site 882094004281 Q-loop/lid; other site 882094004282 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 882094004283 ABC transporter signature motif; other site 882094004284 Walker B; other site 882094004285 D-loop; other site 882094004286 H-loop/switch region; other site 882094004287 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 882094004288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094004289 nucleotide binding site [chemical binding]; other site 882094004290 Acetokinase family; Region: Acetate_kinase; cl17229 882094004291 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 882094004292 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094004293 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882094004294 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 882094004295 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 882094004296 tetramer interface [polypeptide binding]; other site 882094004297 TPP-binding site [chemical binding]; other site 882094004298 heterodimer interface [polypeptide binding]; other site 882094004299 phosphorylation loop region [posttranslational modification] 882094004300 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 882094004301 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 882094004302 alpha subunit interface [polypeptide binding]; other site 882094004303 TPP binding site [chemical binding]; other site 882094004304 heterodimer interface [polypeptide binding]; other site 882094004305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 882094004306 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 882094004307 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 882094004308 E3 interaction surface; other site 882094004309 lipoyl attachment site [posttranslational modification]; other site 882094004310 e3 binding domain; Region: E3_binding; pfam02817 882094004311 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 882094004312 peptidase T-like protein; Region: PepT-like; TIGR01883 882094004313 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 882094004314 metal binding site [ion binding]; metal-binding site 882094004315 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 882094004316 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 882094004317 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 882094004318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094004319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094004320 active site 882094004321 phosphorylation site [posttranslational modification] 882094004322 intermolecular recognition site; other site 882094004323 dimerization interface [polypeptide binding]; other site 882094004324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094004325 DNA binding site [nucleotide binding] 882094004326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882094004327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094004328 dimerization interface [polypeptide binding]; other site 882094004329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094004330 dimer interface [polypeptide binding]; other site 882094004331 phosphorylation site [posttranslational modification] 882094004332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094004333 ATP binding site [chemical binding]; other site 882094004334 Mg2+ binding site [ion binding]; other site 882094004335 G-X-G motif; other site 882094004336 OxaA-like protein precursor; Validated; Region: PRK01622 882094004337 acylphosphatase; Provisional; Region: PRK14443 882094004338 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 882094004339 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 882094004340 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 882094004341 homotetramer interface [polypeptide binding]; other site 882094004342 FMN binding site [chemical binding]; other site 882094004343 homodimer contacts [polypeptide binding]; other site 882094004344 putative active site [active] 882094004345 putative substrate binding site [chemical binding]; other site 882094004346 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 882094004347 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 882094004348 active site residue [active] 882094004349 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 882094004350 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882094004351 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094004352 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094004353 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 882094004354 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882094004355 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882094004356 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882094004357 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 882094004358 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 882094004359 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 882094004360 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 882094004361 ligand binding site [chemical binding]; other site 882094004362 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 882094004363 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 882094004364 Walker A/P-loop; other site 882094004365 ATP binding site [chemical binding]; other site 882094004366 Q-loop/lid; other site 882094004367 ABC transporter signature motif; other site 882094004368 Walker B; other site 882094004369 D-loop; other site 882094004370 H-loop/switch region; other site 882094004371 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 882094004372 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882094004373 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882094004374 TM-ABC transporter signature motif; other site 882094004375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 882094004376 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 882094004377 TM-ABC transporter signature motif; other site 882094004378 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882094004379 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882094004380 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 882094004381 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 882094004382 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 882094004383 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882094004384 classical (c) SDRs; Region: SDR_c; cd05233 882094004385 NAD(P) binding site [chemical binding]; other site 882094004386 active site 882094004387 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 882094004388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094004389 non-specific DNA binding site [nucleotide binding]; other site 882094004390 salt bridge; other site 882094004391 sequence-specific DNA binding site [nucleotide binding]; other site 882094004392 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 882094004393 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 882094004394 competence damage-inducible protein A; Provisional; Region: PRK00549 882094004395 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 882094004396 putative MPT binding site; other site 882094004397 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 882094004398 recombinase A; Provisional; Region: recA; PRK09354 882094004399 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 882094004400 hexamer interface [polypeptide binding]; other site 882094004401 Walker A motif; other site 882094004402 ATP binding site [chemical binding]; other site 882094004403 Walker B motif; other site 882094004404 phosphodiesterase; Provisional; Region: PRK12704 882094004405 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094004406 Zn2+ binding site [ion binding]; other site 882094004407 Mg2+ binding site [ion binding]; other site 882094004408 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 882094004409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094004410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882094004411 Coenzyme A binding pocket [chemical binding]; other site 882094004412 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 882094004413 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882094004414 putative active site [active] 882094004415 metal binding site [ion binding]; metal-binding site 882094004416 homodimer binding site [polypeptide binding]; other site 882094004417 Predicted membrane protein [Function unknown]; Region: COG4550 882094004418 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 882094004419 MutS domain I; Region: MutS_I; pfam01624 882094004420 MutS domain II; Region: MutS_II; pfam05188 882094004421 MutS domain III; Region: MutS_III; pfam05192 882094004422 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 882094004423 Walker A/P-loop; other site 882094004424 ATP binding site [chemical binding]; other site 882094004425 Q-loop/lid; other site 882094004426 ABC transporter signature motif; other site 882094004427 Walker B; other site 882094004428 D-loop; other site 882094004429 H-loop/switch region; other site 882094004430 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 882094004431 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094004432 ATP binding site [chemical binding]; other site 882094004433 Mg2+ binding site [ion binding]; other site 882094004434 G-X-G motif; other site 882094004435 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 882094004436 ATP binding site [chemical binding]; other site 882094004437 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 882094004438 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 882094004439 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882094004440 Pyruvate formate lyase 1; Region: PFL1; cd01678 882094004441 coenzyme A binding site [chemical binding]; other site 882094004442 active site 882094004443 catalytic residues [active] 882094004444 glycine loop; other site 882094004445 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 882094004446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882094004447 FeS/SAM binding site; other site 882094004448 Predicted transcriptional regulators [Transcription]; Region: COG1695 882094004449 Transcriptional regulator PadR-like family; Region: PadR; cl17335 882094004450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094004451 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094004452 putative substrate translocation pore; other site 882094004453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882094004454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094004455 non-specific DNA binding site [nucleotide binding]; other site 882094004456 salt bridge; other site 882094004457 sequence-specific DNA binding site [nucleotide binding]; other site 882094004458 topology modulation protein; Reviewed; Region: PRK08118 882094004459 AAA domain; Region: AAA_17; pfam13207 882094004460 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094004461 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094004462 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094004463 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094004464 putative acyltransferase; Provisional; Region: PRK05790 882094004465 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 882094004466 dimer interface [polypeptide binding]; other site 882094004467 active site 882094004468 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 882094004469 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 882094004470 dimer interface [polypeptide binding]; other site 882094004471 active site 882094004472 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882094004473 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 882094004474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094004475 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 882094004476 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 882094004477 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 882094004478 Domain of unknown function DUF20; Region: UPF0118; pfam01594 882094004479 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 882094004480 FAD binding domain; Region: FAD_binding_4; pfam01565 882094004481 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 882094004482 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 882094004483 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882094004484 Walker A/P-loop; other site 882094004485 ATP binding site [chemical binding]; other site 882094004486 Q-loop/lid; other site 882094004487 ABC transporter signature motif; other site 882094004488 Walker B; other site 882094004489 D-loop; other site 882094004490 H-loop/switch region; other site 882094004491 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094004492 dimer interface [polypeptide binding]; other site 882094004493 conserved gate region; other site 882094004494 ABC-ATPase subunit interface; other site 882094004495 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 882094004496 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 882094004497 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 882094004498 manganese transport protein MntH; Reviewed; Region: PRK00701 882094004499 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 882094004500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094004501 dimer interface [polypeptide binding]; other site 882094004502 conserved gate region; other site 882094004503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 882094004504 ABC-ATPase subunit interface; other site 882094004505 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 882094004506 LysR substrate binding domain; Region: LysR_substrate; pfam03466 882094004507 dimerization interface [polypeptide binding]; other site 882094004508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094004509 dimer interface [polypeptide binding]; other site 882094004510 conserved gate region; other site 882094004511 putative PBP binding loops; other site 882094004512 ABC-ATPase subunit interface; other site 882094004513 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 882094004514 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 882094004515 Walker A/P-loop; other site 882094004516 ATP binding site [chemical binding]; other site 882094004517 Q-loop/lid; other site 882094004518 ABC transporter signature motif; other site 882094004519 Walker B; other site 882094004520 D-loop; other site 882094004521 H-loop/switch region; other site 882094004522 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 882094004523 Predicted membrane protein [Function unknown]; Region: COG3859 882094004524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882094004525 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 882094004526 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094004527 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094004528 ABC transporter; Region: ABC_tran_2; pfam12848 882094004529 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094004530 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 882094004531 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094004532 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094004533 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 882094004534 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 882094004535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094004536 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 882094004537 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 882094004538 dihydrodipicolinate synthase; Region: dapA; TIGR00674 882094004539 dimer interface [polypeptide binding]; other site 882094004540 active site 882094004541 catalytic residue [active] 882094004542 aspartate kinase I; Reviewed; Region: PRK08210 882094004543 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 882094004544 nucleotide binding site [chemical binding]; other site 882094004545 substrate binding site [chemical binding]; other site 882094004546 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 882094004547 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 882094004548 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 882094004549 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882094004550 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882094004551 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882094004552 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882094004553 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 882094004554 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 882094004555 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 882094004556 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 882094004557 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 882094004558 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 882094004559 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 882094004560 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 882094004561 Predicted membrane protein [Function unknown]; Region: COG4392 882094004562 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882094004563 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882094004564 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882094004565 metal binding site 2 [ion binding]; metal-binding site 882094004566 putative DNA binding helix; other site 882094004567 metal binding site 1 [ion binding]; metal-binding site 882094004568 dimer interface [polypeptide binding]; other site 882094004569 structural Zn2+ binding site [ion binding]; other site 882094004570 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882094004571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094004572 ABC-ATPase subunit interface; other site 882094004573 dimer interface [polypeptide binding]; other site 882094004574 putative PBP binding regions; other site 882094004575 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 882094004576 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882094004577 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 882094004578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 882094004579 DHHA2 domain; Region: DHHA2; pfam02833 882094004580 endonuclease IV; Provisional; Region: PRK01060 882094004581 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 882094004582 AP (apurinic/apyrimidinic) site pocket; other site 882094004583 DNA interaction; other site 882094004584 Metal-binding active site; metal-binding site 882094004585 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 882094004586 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882094004587 ATP binding site [chemical binding]; other site 882094004588 Mg++ binding site [ion binding]; other site 882094004589 motif III; other site 882094004590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094004591 nucleotide binding region [chemical binding]; other site 882094004592 ATP-binding site [chemical binding]; other site 882094004593 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 882094004594 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 882094004595 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882094004596 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882094004597 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 882094004598 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 882094004599 Uncharacterized conserved protein [Function unknown]; Region: COG0327 882094004600 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 882094004601 Family of unknown function (DUF633); Region: DUF633; pfam04816 882094004602 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 882094004603 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 882094004604 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 882094004605 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 882094004606 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 882094004607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 882094004608 DNA binding residues [nucleotide binding] 882094004609 DNA primase; Validated; Region: dnaG; PRK05667 882094004610 CHC2 zinc finger; Region: zf-CHC2; pfam01807 882094004611 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 882094004612 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 882094004613 active site 882094004614 metal binding site [ion binding]; metal-binding site 882094004615 interdomain interaction site; other site 882094004616 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 882094004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 882094004618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 882094004619 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 882094004620 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 882094004621 DALR anticodon binding domain; Region: DALR_1; pfam05746 882094004622 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 882094004623 dimer interface [polypeptide binding]; other site 882094004624 motif 1; other site 882094004625 active site 882094004626 motif 2; other site 882094004627 motif 3; other site 882094004628 DNA repair protein RecO; Region: reco; TIGR00613 882094004629 Recombination protein O N terminal; Region: RecO_N; pfam11967 882094004630 Recombination protein O C terminal; Region: RecO_C; pfam02565 882094004631 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 882094004632 GTPase Era; Reviewed; Region: era; PRK00089 882094004633 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 882094004634 G1 box; other site 882094004635 GTP/Mg2+ binding site [chemical binding]; other site 882094004636 Switch I region; other site 882094004637 G2 box; other site 882094004638 Switch II region; other site 882094004639 G3 box; other site 882094004640 G4 box; other site 882094004641 G5 box; other site 882094004642 KH domain; Region: KH_2; pfam07650 882094004643 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 882094004644 active site 882094004645 catalytic motif [active] 882094004646 Zn binding site [ion binding]; other site 882094004647 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 882094004648 metal-binding heat shock protein; Provisional; Region: PRK00016 882094004649 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 882094004650 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 882094004651 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094004652 Zn2+ binding site [ion binding]; other site 882094004653 Mg2+ binding site [ion binding]; other site 882094004654 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 882094004655 PhoH-like protein; Region: PhoH; pfam02562 882094004656 Yqey-like protein; Region: YqeY; pfam09424 882094004657 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 882094004658 RNA methyltransferase, RsmE family; Region: TIGR00046 882094004659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 882094004660 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 882094004661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094004662 S-adenosylmethionine binding site [chemical binding]; other site 882094004663 chaperone protein DnaJ; Provisional; Region: PRK14280 882094004664 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 882094004665 HSP70 interaction site [polypeptide binding]; other site 882094004666 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 882094004667 substrate binding site [polypeptide binding]; other site 882094004668 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 882094004669 Zn binding sites [ion binding]; other site 882094004670 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 882094004671 dimer interface [polypeptide binding]; other site 882094004672 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 882094004673 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 882094004674 nucleotide binding site [chemical binding]; other site 882094004675 NEF interaction site [polypeptide binding]; other site 882094004676 SBD interface [polypeptide binding]; other site 882094004677 heat shock protein GrpE; Provisional; Region: PRK14140 882094004678 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 882094004679 dimer interface [polypeptide binding]; other site 882094004680 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 882094004681 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 882094004682 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 882094004683 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 882094004684 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882094004685 FeS/SAM binding site; other site 882094004686 HemN C-terminal domain; Region: HemN_C; pfam06969 882094004687 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882094004688 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 882094004689 NADP binding site [chemical binding]; other site 882094004690 putative substrate binding site [chemical binding]; other site 882094004691 active site 882094004692 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094004693 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094004694 DNA binding residues [nucleotide binding] 882094004695 putative dimer interface [polypeptide binding]; other site 882094004696 GTP-binding protein LepA; Provisional; Region: PRK05433 882094004697 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 882094004698 G1 box; other site 882094004699 putative GEF interaction site [polypeptide binding]; other site 882094004700 GTP/Mg2+ binding site [chemical binding]; other site 882094004701 Switch I region; other site 882094004702 G2 box; other site 882094004703 G3 box; other site 882094004704 Switch II region; other site 882094004705 G4 box; other site 882094004706 G5 box; other site 882094004707 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 882094004708 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 882094004709 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 882094004710 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 882094004711 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 882094004712 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 882094004713 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 882094004714 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 882094004715 Competence protein; Region: Competence; pfam03772 882094004716 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094004717 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 882094004718 catalytic motif [active] 882094004719 Zn binding site [ion binding]; other site 882094004720 SLBB domain; Region: SLBB; pfam10531 882094004721 comEA protein; Region: comE; TIGR01259 882094004722 Helix-hairpin-helix motif; Region: HHH; pfam00633 882094004723 Methyltransferase domain; Region: Methyltransf_23; pfam13489 882094004724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094004725 S-adenosylmethionine binding site [chemical binding]; other site 882094004726 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 882094004727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094004728 Zn2+ binding site [ion binding]; other site 882094004729 Mg2+ binding site [ion binding]; other site 882094004730 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 882094004731 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 882094004732 active site 882094004733 (T/H)XGH motif; other site 882094004734 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 882094004735 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 882094004736 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882094004737 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882094004738 shikimate binding site; other site 882094004739 NAD(P) binding site [chemical binding]; other site 882094004740 GTPase YqeH; Provisional; Region: PRK13796 882094004741 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 882094004742 GTP/Mg2+ binding site [chemical binding]; other site 882094004743 G4 box; other site 882094004744 G5 box; other site 882094004745 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 882094004746 G1 box; other site 882094004747 G1 box; other site 882094004748 GTP/Mg2+ binding site [chemical binding]; other site 882094004749 G2 box; other site 882094004750 Switch I region; other site 882094004751 G2 box; other site 882094004752 Switch I region; other site 882094004753 G3 box; other site 882094004754 G3 box; other site 882094004755 Switch II region; other site 882094004756 Switch II region; other site 882094004757 G4 box; other site 882094004758 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 882094004759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094004760 motif II; other site 882094004761 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 882094004762 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 882094004763 active site 882094004764 Zn binding site [ion binding]; other site 882094004765 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 882094004766 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 882094004767 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 882094004768 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 882094004769 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 882094004770 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 882094004771 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 882094004772 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 882094004773 Sugar specificity; other site 882094004774 Pyrimidine base specificity; other site 882094004775 ATP-binding site [chemical binding]; other site 882094004776 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 882094004777 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094004778 S-adenosylmethionine binding site [chemical binding]; other site 882094004779 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 882094004780 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 882094004781 dimerization interface [polypeptide binding]; other site 882094004782 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882094004783 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882094004784 hypothetical protein; Provisional; Region: PRK13678 882094004785 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 882094004786 hypothetical protein; Provisional; Region: PRK05473 882094004787 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 882094004788 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 882094004789 motif 1; other site 882094004790 active site 882094004791 motif 2; other site 882094004792 motif 3; other site 882094004793 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882094004794 DHHA1 domain; Region: DHHA1; pfam02272 882094004795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094004796 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094004797 Walker A/P-loop; other site 882094004798 ATP binding site [chemical binding]; other site 882094004799 Q-loop/lid; other site 882094004800 ABC transporter signature motif; other site 882094004801 Walker B; other site 882094004802 D-loop; other site 882094004803 H-loop/switch region; other site 882094004804 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094004805 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882094004806 FtsX-like permease family; Region: FtsX; pfam02687 882094004807 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094004808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094004809 active site 882094004810 phosphorylation site [posttranslational modification] 882094004811 intermolecular recognition site; other site 882094004812 dimerization interface [polypeptide binding]; other site 882094004813 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094004814 DNA binding site [nucleotide binding] 882094004815 sensor kinase CusS; Provisional; Region: PRK09835 882094004816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094004817 dimerization interface [polypeptide binding]; other site 882094004818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094004819 dimer interface [polypeptide binding]; other site 882094004820 phosphorylation site [posttranslational modification] 882094004821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094004822 ATP binding site [chemical binding]; other site 882094004823 Mg2+ binding site [ion binding]; other site 882094004824 G-X-G motif; other site 882094004825 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 882094004826 AAA domain; Region: AAA_30; pfam13604 882094004827 Family description; Region: UvrD_C_2; pfam13538 882094004828 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094004829 binding surface 882094004830 TPR motif; other site 882094004831 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 882094004832 TPR repeat; Region: TPR_11; pfam13414 882094004833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094004834 binding surface 882094004835 TPR motif; other site 882094004836 TPR repeat; Region: TPR_11; pfam13414 882094004837 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 882094004838 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 882094004839 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 882094004840 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882094004841 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882094004842 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094004843 catalytic residue [active] 882094004844 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 882094004845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094004846 Walker A motif; other site 882094004847 ATP binding site [chemical binding]; other site 882094004848 Walker B motif; other site 882094004849 arginine finger; other site 882094004850 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 882094004851 Predicted transcriptional regulator [Transcription]; Region: COG1959 882094004852 Transcriptional regulator; Region: Rrf2; pfam02082 882094004853 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 882094004854 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 882094004855 Nitrogen regulatory protein P-II; Region: P-II; smart00938 882094004856 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 882094004857 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 882094004858 dimer interface [polypeptide binding]; other site 882094004859 anticodon binding site; other site 882094004860 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 882094004861 homodimer interface [polypeptide binding]; other site 882094004862 motif 1; other site 882094004863 active site 882094004864 motif 2; other site 882094004865 GAD domain; Region: GAD; pfam02938 882094004866 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 882094004867 motif 3; other site 882094004868 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 882094004869 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 882094004870 dimer interface [polypeptide binding]; other site 882094004871 motif 1; other site 882094004872 active site 882094004873 motif 2; other site 882094004874 motif 3; other site 882094004875 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 882094004876 anticodon binding site; other site 882094004877 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 882094004878 Bacterial SH3 domain; Region: SH3_3; pfam08239 882094004879 Bacterial SH3 domain; Region: SH3_3; pfam08239 882094004880 Bacterial SH3 domain homologues; Region: SH3b; smart00287 882094004881 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 882094004882 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 882094004883 active site 882094004884 metal binding site [ion binding]; metal-binding site 882094004885 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 882094004886 putative active site [active] 882094004887 dimerization interface [polypeptide binding]; other site 882094004888 putative tRNAtyr binding site [nucleotide binding]; other site 882094004889 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 882094004890 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094004891 Zn2+ binding site [ion binding]; other site 882094004892 Mg2+ binding site [ion binding]; other site 882094004893 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 882094004894 synthetase active site [active] 882094004895 NTP binding site [chemical binding]; other site 882094004896 metal binding site [ion binding]; metal-binding site 882094004897 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 882094004898 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 882094004899 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094004900 active site 882094004901 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 882094004902 DHH family; Region: DHH; pfam01368 882094004903 DHHA1 domain; Region: DHHA1; pfam02272 882094004904 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 882094004905 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 882094004906 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 882094004907 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 882094004908 Protein export membrane protein; Region: SecD_SecF; cl14618 882094004909 Protein export membrane protein; Region: SecD_SecF; pfam02355 882094004910 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 882094004911 Preprotein translocase subunit; Region: YajC; pfam02699 882094004912 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 882094004913 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 882094004914 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 882094004915 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 882094004916 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 882094004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094004918 Walker A motif; other site 882094004919 ATP binding site [chemical binding]; other site 882094004920 Walker B motif; other site 882094004921 arginine finger; other site 882094004922 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 882094004923 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 882094004924 RuvA N terminal domain; Region: RuvA_N; pfam01330 882094004925 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 882094004926 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882094004927 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094004928 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882094004929 NAD binding site [chemical binding]; other site 882094004930 dimer interface [polypeptide binding]; other site 882094004931 substrate binding site [chemical binding]; other site 882094004932 hypothetical protein; Validated; Region: PRK00110 882094004933 prephenate dehydratase; Provisional; Region: PRK11898 882094004934 Prephenate dehydratase; Region: PDT; pfam00800 882094004935 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 882094004936 putative L-Phe binding site [chemical binding]; other site 882094004937 GTPase CgtA; Reviewed; Region: obgE; PRK12297 882094004938 GTP1/OBG; Region: GTP1_OBG; pfam01018 882094004939 Obg GTPase; Region: Obg; cd01898 882094004940 G1 box; other site 882094004941 GTP/Mg2+ binding site [chemical binding]; other site 882094004942 Switch I region; other site 882094004943 G2 box; other site 882094004944 G3 box; other site 882094004945 Switch II region; other site 882094004946 G4 box; other site 882094004947 G5 box; other site 882094004948 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 882094004949 glycerol kinase; Provisional; Region: glpK; PRK00047 882094004950 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 882094004951 N- and C-terminal domain interface [polypeptide binding]; other site 882094004952 active site 882094004953 MgATP binding site [chemical binding]; other site 882094004954 catalytic site [active] 882094004955 metal binding site [ion binding]; metal-binding site 882094004956 glycerol binding site [chemical binding]; other site 882094004957 homotetramer interface [polypeptide binding]; other site 882094004958 homodimer interface [polypeptide binding]; other site 882094004959 FBP binding site [chemical binding]; other site 882094004960 protein IIAGlc interface [polypeptide binding]; other site 882094004961 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 882094004962 amphipathic channel; other site 882094004963 Asn-Pro-Ala signature motifs; other site 882094004964 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 882094004965 hypothetical protein; Provisional; Region: PRK14553 882094004966 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 882094004967 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 882094004968 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 882094004969 homodimer interface [polypeptide binding]; other site 882094004970 oligonucleotide binding site [chemical binding]; other site 882094004971 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 882094004972 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 882094004973 Switch I; other site 882094004974 Switch II; other site 882094004975 septum formation inhibitor; Reviewed; Region: minC; PRK00513 882094004976 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 882094004977 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 882094004978 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 882094004979 Protein of unknown function (DUF972); Region: DUF972; pfam06156 882094004980 rod shape-determining protein MreC; Region: MreC; pfam04085 882094004981 rod shape-determining protein MreB; Provisional; Region: PRK13927 882094004982 MreB and similar proteins; Region: MreB_like; cd10225 882094004983 nucleotide binding site [chemical binding]; other site 882094004984 Mg binding site [ion binding]; other site 882094004985 putative protofilament interaction site [polypeptide binding]; other site 882094004986 RodZ interaction site [polypeptide binding]; other site 882094004987 hypothetical protein; Reviewed; Region: PRK00024 882094004988 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 882094004989 MPN+ (JAMM) motif; other site 882094004990 Zinc-binding site [ion binding]; other site 882094004991 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 882094004992 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 882094004993 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 882094004994 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882094004995 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882094004996 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 882094004997 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 882094004998 active site 882094004999 HIGH motif; other site 882094005000 nucleotide binding site [chemical binding]; other site 882094005001 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882094005002 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 882094005003 active site 882094005004 KMSKS motif; other site 882094005005 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 882094005006 tRNA binding surface [nucleotide binding]; other site 882094005007 anticodon binding site; other site 882094005008 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 882094005009 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 882094005010 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882094005011 inhibitor-cofactor binding pocket; inhibition site 882094005012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005013 catalytic residue [active] 882094005014 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 882094005015 dimer interface [polypeptide binding]; other site 882094005016 active site 882094005017 Schiff base residues; other site 882094005018 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 882094005019 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 882094005020 active site 882094005021 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 882094005022 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 882094005023 domain interfaces; other site 882094005024 active site 882094005025 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 882094005026 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 882094005027 tRNA; other site 882094005028 putative tRNA binding site [nucleotide binding]; other site 882094005029 putative NADP binding site [chemical binding]; other site 882094005030 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 882094005031 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 882094005032 G1 box; other site 882094005033 GTP/Mg2+ binding site [chemical binding]; other site 882094005034 Switch I region; other site 882094005035 G2 box; other site 882094005036 G3 box; other site 882094005037 Switch II region; other site 882094005038 G4 box; other site 882094005039 G5 box; other site 882094005040 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 882094005041 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 882094005042 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 882094005043 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 882094005044 active site 882094005045 dimer interface [polypeptide binding]; other site 882094005046 motif 1; other site 882094005047 motif 2; other site 882094005048 motif 3; other site 882094005049 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 882094005050 anticodon binding site; other site 882094005051 primosomal protein DnaI; Reviewed; Region: PRK08939 882094005052 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 882094005053 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 882094005054 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882094005055 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 882094005056 ATP cone domain; Region: ATP-cone; pfam03477 882094005057 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 882094005058 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 882094005059 CoA-binding site [chemical binding]; other site 882094005060 ATP-binding [chemical binding]; other site 882094005061 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 882094005062 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 882094005063 DNA binding site [nucleotide binding] 882094005064 catalytic residue [active] 882094005065 H2TH interface [polypeptide binding]; other site 882094005066 putative catalytic residues [active] 882094005067 turnover-facilitating residue; other site 882094005068 intercalation triad [nucleotide binding]; other site 882094005069 8OG recognition residue [nucleotide binding]; other site 882094005070 putative reading head residues; other site 882094005071 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 882094005072 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882094005073 DNA polymerase I; Provisional; Region: PRK05755 882094005074 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882094005075 active site 882094005076 metal binding site 1 [ion binding]; metal-binding site 882094005077 putative 5' ssDNA interaction site; other site 882094005078 metal binding site 3; metal-binding site 882094005079 metal binding site 2 [ion binding]; metal-binding site 882094005080 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882094005081 putative DNA binding site [nucleotide binding]; other site 882094005082 putative metal binding site [ion binding]; other site 882094005083 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 882094005084 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 882094005085 active site 882094005086 DNA binding site [nucleotide binding] 882094005087 catalytic site [active] 882094005088 isocitrate dehydrogenase; Reviewed; Region: PRK07006 882094005089 isocitrate dehydrogenase; Validated; Region: PRK07362 882094005090 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 882094005091 dimer interface [polypeptide binding]; other site 882094005092 Citrate synthase; Region: Citrate_synt; pfam00285 882094005093 active site 882094005094 citrylCoA binding site [chemical binding]; other site 882094005095 oxalacetate/citrate binding site [chemical binding]; other site 882094005096 coenzyme A binding site [chemical binding]; other site 882094005097 catalytic triad [active] 882094005098 Protein of unknown function (DUF441); Region: DUF441; pfam04284 882094005099 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 882094005100 pyruvate kinase; Provisional; Region: PRK06354 882094005101 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 882094005102 domain interfaces; other site 882094005103 active site 882094005104 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 882094005105 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 882094005106 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 882094005107 active site 882094005108 ADP/pyrophosphate binding site [chemical binding]; other site 882094005109 dimerization interface [polypeptide binding]; other site 882094005110 allosteric effector site; other site 882094005111 fructose-1,6-bisphosphate binding site; other site 882094005112 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 882094005113 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 882094005114 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 882094005115 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 882094005116 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 882094005117 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 882094005118 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 882094005119 active site 882094005120 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 882094005121 generic binding surface I; other site 882094005122 generic binding surface II; other site 882094005123 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 882094005124 DHH family; Region: DHH; pfam01368 882094005125 DHHA1 domain; Region: DHHA1; pfam02272 882094005126 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 882094005127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 882094005128 DNA-binding site [nucleotide binding]; DNA binding site 882094005129 DRTGG domain; Region: DRTGG; pfam07085 882094005130 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 882094005131 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 882094005132 active site 2 [active] 882094005133 active site 1 [active] 882094005134 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 882094005135 metal-dependent hydrolase; Provisional; Region: PRK00685 882094005136 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 882094005137 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 882094005138 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 882094005139 active site 882094005140 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 882094005141 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 882094005142 hexamer interface [polypeptide binding]; other site 882094005143 ligand binding site [chemical binding]; other site 882094005144 putative active site [active] 882094005145 NAD(P) binding site [chemical binding]; other site 882094005146 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882094005147 Ligand Binding Site [chemical binding]; other site 882094005148 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 882094005149 propionate/acetate kinase; Provisional; Region: PRK12379 882094005150 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 882094005151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005152 S-adenosylmethionine binding site [chemical binding]; other site 882094005153 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 882094005154 dimer interface [polypeptide binding]; other site 882094005155 catalytic triad [active] 882094005156 peroxidatic and resolving cysteines [active] 882094005157 RDD family; Region: RDD; pfam06271 882094005158 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 882094005159 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 882094005160 tandem repeat interface [polypeptide binding]; other site 882094005161 oligomer interface [polypeptide binding]; other site 882094005162 active site residues [active] 882094005163 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 882094005164 ATP-NAD kinase; Region: NAD_kinase; pfam01513 882094005165 ornithine carbamoyltransferase; Provisional; Region: PRK00779 882094005166 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882094005167 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882094005168 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 882094005169 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882094005170 inhibitor-cofactor binding pocket; inhibition site 882094005171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005172 catalytic residue [active] 882094005173 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 882094005174 nucleotide binding site [chemical binding]; other site 882094005175 N-acetyl-L-glutamate binding site [chemical binding]; other site 882094005176 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 882094005177 heterotetramer interface [polypeptide binding]; other site 882094005178 active site pocket [active] 882094005179 cleavage site 882094005180 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 882094005181 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 882094005182 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 882094005183 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 882094005184 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 882094005185 Ligand Binding Site [chemical binding]; other site 882094005186 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882094005187 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882094005188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094005189 catalytic residue [active] 882094005190 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 882094005191 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 882094005192 GAF domain; Region: GAF_2; pfam13185 882094005193 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 882094005194 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 882094005195 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094005196 RNA binding surface [nucleotide binding]; other site 882094005197 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 882094005198 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 882094005199 active site 882094005200 HIGH motif; other site 882094005201 dimer interface [polypeptide binding]; other site 882094005202 KMSKS motif; other site 882094005203 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094005204 RNA binding surface [nucleotide binding]; other site 882094005205 catabolite control protein A; Region: ccpA; TIGR01481 882094005206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094005207 DNA binding site [nucleotide binding] 882094005208 domain linker motif; other site 882094005209 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 882094005210 dimerization interface [polypeptide binding]; other site 882094005211 effector binding site; other site 882094005212 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 882094005213 Chorismate mutase type II; Region: CM_2; cl00693 882094005214 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 882094005215 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882094005216 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 882094005217 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882094005218 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882094005219 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 882094005220 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 882094005221 dimer interface [polypeptide binding]; other site 882094005222 decamer (pentamer of dimers) interface [polypeptide binding]; other site 882094005223 catalytic triad [active] 882094005224 peroxidatic and resolving cysteines [active] 882094005225 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 882094005226 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882094005227 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882094005228 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882094005229 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 882094005230 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 882094005231 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 882094005232 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 882094005233 putative tRNA-binding site [nucleotide binding]; other site 882094005234 hypothetical protein; Provisional; Region: PRK13668 882094005235 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094005236 catalytic residues [active] 882094005237 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882094005238 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 882094005239 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 882094005240 oligomer interface [polypeptide binding]; other site 882094005241 active site 882094005242 metal binding site [ion binding]; metal-binding site 882094005243 Predicted small secreted protein [Function unknown]; Region: COG5584 882094005244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 882094005245 putative homodimer interface [polypeptide binding]; other site 882094005246 putative homotetramer interface [polypeptide binding]; other site 882094005247 putative allosteric switch controlling residues; other site 882094005248 putative metal binding site [ion binding]; other site 882094005249 putative homodimer-homodimer interface [polypeptide binding]; other site 882094005250 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094005251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005252 S-adenosylmethionine binding site [chemical binding]; other site 882094005253 Phosphotransferase enzyme family; Region: APH; pfam01636 882094005254 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882094005255 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882094005256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094005257 putative substrate translocation pore; other site 882094005258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094005259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094005260 MarR family; Region: MarR; pfam01047 882094005261 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882094005262 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 882094005263 homodimer interface [polypeptide binding]; other site 882094005264 substrate-cofactor binding pocket; other site 882094005265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005266 catalytic residue [active] 882094005267 dipeptidase PepV; Reviewed; Region: PRK07318 882094005268 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 882094005269 active site 882094005270 metal binding site [ion binding]; metal-binding site 882094005271 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 882094005272 nudix motif; other site 882094005273 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 882094005274 putative substrate binding site [chemical binding]; other site 882094005275 putative ATP binding site [chemical binding]; other site 882094005276 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882094005277 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882094005278 active site 882094005279 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882094005280 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882094005281 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 882094005282 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 882094005283 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 882094005284 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 882094005285 substrate binding site [chemical binding]; other site 882094005286 active site 882094005287 catalytic residues [active] 882094005288 heterodimer interface [polypeptide binding]; other site 882094005289 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 882094005290 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 882094005291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005292 catalytic residue [active] 882094005293 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 882094005294 active site 882094005295 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 882094005296 active site 882094005297 ribulose/triose binding site [chemical binding]; other site 882094005298 phosphate binding site [ion binding]; other site 882094005299 substrate (anthranilate) binding pocket [chemical binding]; other site 882094005300 product (indole) binding pocket [chemical binding]; other site 882094005301 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 882094005302 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882094005303 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882094005304 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882094005305 Glutamine amidotransferase class-I; Region: GATase; pfam00117 882094005306 glutamine binding [chemical binding]; other site 882094005307 catalytic triad [active] 882094005308 anthranilate synthase component I; Provisional; Region: PRK13570 882094005309 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 882094005310 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 882094005311 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 882094005312 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 882094005313 putative catalytic cysteine [active] 882094005314 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 882094005315 putative active site [active] 882094005316 metal binding site [ion binding]; metal-binding site 882094005317 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882094005318 dimer interface [polypeptide binding]; other site 882094005319 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094005320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094005321 Walker A/P-loop; other site 882094005322 ATP binding site [chemical binding]; other site 882094005323 Q-loop/lid; other site 882094005324 ABC transporter signature motif; other site 882094005325 Walker B; other site 882094005326 D-loop; other site 882094005327 H-loop/switch region; other site 882094005328 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882094005329 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882094005330 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 882094005331 putative dimer interface [polypeptide binding]; other site 882094005332 catalytic triad [active] 882094005333 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 882094005334 aconitate hydratase; Validated; Region: PRK09277 882094005335 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 882094005336 substrate binding site [chemical binding]; other site 882094005337 ligand binding site [chemical binding]; other site 882094005338 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 882094005339 substrate binding site [chemical binding]; other site 882094005340 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094005341 Heat induced stress protein YflT; Region: YflT; pfam11181 882094005342 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 882094005343 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 882094005344 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094005345 ATP binding site [chemical binding]; other site 882094005346 putative Mg++ binding site [ion binding]; other site 882094005347 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094005348 nucleotide binding region [chemical binding]; other site 882094005349 ATP-binding site [chemical binding]; other site 882094005350 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 882094005351 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882094005352 Walker A/P-loop; other site 882094005353 ATP binding site [chemical binding]; other site 882094005354 Q-loop/lid; other site 882094005355 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 882094005356 ABC transporter signature motif; other site 882094005357 Walker B; other site 882094005358 D-loop; other site 882094005359 H-loop/switch region; other site 882094005360 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882094005361 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882094005362 active site 882094005363 metal binding site [ion binding]; metal-binding site 882094005364 DNA binding site [nucleotide binding] 882094005365 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 882094005366 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 882094005367 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 882094005368 putative acyl-acceptor binding pocket; other site 882094005369 Membrane protein involved in cytochrome C biogenesis [Posttranslational modification, protein turnover, chaperones]; Region: CcdC; COG4846 882094005370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094005371 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094005372 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 882094005373 Walker A/P-loop; other site 882094005374 ATP binding site [chemical binding]; other site 882094005375 Q-loop/lid; other site 882094005376 ABC transporter signature motif; other site 882094005377 Walker B; other site 882094005378 D-loop; other site 882094005379 H-loop/switch region; other site 882094005380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094005381 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 882094005382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094005383 Walker A/P-loop; other site 882094005384 ATP binding site [chemical binding]; other site 882094005385 Q-loop/lid; other site 882094005386 ABC transporter signature motif; other site 882094005387 Walker B; other site 882094005388 D-loop; other site 882094005389 H-loop/switch region; other site 882094005390 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 882094005391 active site 882094005392 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882094005393 elongation factor Ts; Provisional; Region: tsf; PRK09377 882094005394 UBA/TS-N domain; Region: UBA; pfam00627 882094005395 Elongation factor TS; Region: EF_TS; pfam00889 882094005396 Elongation factor TS; Region: EF_TS; pfam00889 882094005397 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 882094005398 rRNA interaction site [nucleotide binding]; other site 882094005399 S8 interaction site; other site 882094005400 putative laminin-1 binding site; other site 882094005401 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 882094005402 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882094005403 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 882094005404 active site turn [active] 882094005405 phosphorylation site [posttranslational modification] 882094005406 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882094005407 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 882094005408 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 882094005409 putative active site [active] 882094005410 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094005411 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094005412 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094005413 putative active site [active] 882094005414 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 882094005415 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882094005416 HIGH motif; other site 882094005417 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 882094005418 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 882094005419 active site 882094005420 KMSKS motif; other site 882094005421 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 882094005422 tRNA binding surface [nucleotide binding]; other site 882094005423 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 882094005424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 882094005425 FeS/SAM binding site; other site 882094005426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005427 S-adenosylmethionine binding site [chemical binding]; other site 882094005428 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 882094005429 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 882094005430 active site 882094005431 dimer interface [polypeptide binding]; other site 882094005432 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 882094005433 Ligand Binding Site [chemical binding]; other site 882094005434 Molecular Tunnel; other site 882094005435 S-adenosylmethionine synthetase; Validated; Region: PRK05250 882094005436 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 882094005437 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 882094005438 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 882094005439 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 882094005440 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 882094005441 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 882094005442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094005443 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 882094005444 NAD binding site [chemical binding]; other site 882094005445 dimer interface [polypeptide binding]; other site 882094005446 substrate binding site [chemical binding]; other site 882094005447 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 882094005448 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 882094005449 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 882094005450 nudix motif; other site 882094005451 Uncharacterized conserved protein [Function unknown]; Region: COG0759 882094005452 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882094005453 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 882094005454 metal binding site [ion binding]; metal-binding site 882094005455 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 882094005456 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 882094005457 acyl-activating enzyme (AAE) consensus motif; other site 882094005458 putative AMP binding site [chemical binding]; other site 882094005459 putative active site [active] 882094005460 putative CoA binding site [chemical binding]; other site 882094005461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 882094005462 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 882094005463 substrate binding site [chemical binding]; other site 882094005464 oxyanion hole (OAH) forming residues; other site 882094005465 trimer interface [polypeptide binding]; other site 882094005466 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094005467 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 882094005468 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 882094005469 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 882094005470 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 882094005471 dimer interface [polypeptide binding]; other site 882094005472 tetramer interface [polypeptide binding]; other site 882094005473 PYR/PP interface [polypeptide binding]; other site 882094005474 TPP binding site [chemical binding]; other site 882094005475 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 882094005476 TPP-binding site; other site 882094005477 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 882094005478 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882094005479 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 882094005480 UbiA prenyltransferase family; Region: UbiA; pfam01040 882094005481 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 882094005482 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 882094005483 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 882094005484 FAD binding site [chemical binding]; other site 882094005485 cystathionine beta-lyase; Provisional; Region: PRK08064 882094005486 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882094005487 homodimer interface [polypeptide binding]; other site 882094005488 substrate-cofactor binding pocket; other site 882094005489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005490 catalytic residue [active] 882094005491 cystathionine gamma-synthase; Reviewed; Region: PRK08247 882094005492 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 882094005493 homodimer interface [polypeptide binding]; other site 882094005494 substrate-cofactor binding pocket; other site 882094005495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005496 catalytic residue [active] 882094005497 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 882094005498 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 882094005499 THF binding site; other site 882094005500 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 882094005501 substrate binding site [chemical binding]; other site 882094005502 THF binding site; other site 882094005503 zinc-binding site [ion binding]; other site 882094005504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094005505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094005506 putative substrate translocation pore; other site 882094005507 ferric uptake regulator; Provisional; Region: fur; PRK09462 882094005508 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882094005509 metal binding site 2 [ion binding]; metal-binding site 882094005510 putative DNA binding helix; other site 882094005511 metal binding site 1 [ion binding]; metal-binding site 882094005512 dimer interface [polypeptide binding]; other site 882094005513 structural Zn2+ binding site [ion binding]; other site 882094005514 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882094005515 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882094005516 NAD binding site [chemical binding]; other site 882094005517 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 882094005518 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 882094005519 inhibitor-cofactor binding pocket; inhibition site 882094005520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094005521 catalytic residue [active] 882094005522 Predicted membrane protein [Function unknown]; Region: COG4129 882094005523 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882094005524 hypothetical protein; Provisional; Region: PRK13662 882094005525 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 882094005526 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 882094005527 putative NAD(P) binding site [chemical binding]; other site 882094005528 active site 882094005529 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 882094005530 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882094005531 minor groove reading motif; other site 882094005532 helix-hairpin-helix signature motif; other site 882094005533 substrate binding pocket [chemical binding]; other site 882094005534 active site 882094005535 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 882094005536 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 882094005537 DNA binding and oxoG recognition site [nucleotide binding] 882094005538 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 882094005539 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 882094005540 trimer interface [polypeptide binding]; other site 882094005541 active site 882094005542 WVELL protein; Region: WVELL; pfam14043 882094005543 recombination regulator RecX; Provisional; Region: recX; PRK14135 882094005544 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882094005545 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 882094005546 NAD(P) binding site [chemical binding]; other site 882094005547 active site 882094005548 Predicted integral membrane protein [Function unknown]; Region: COG0392 882094005549 Uncharacterized conserved protein [Function unknown]; Region: COG2898 882094005550 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 882094005551 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 882094005552 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882094005553 Cation efflux family; Region: Cation_efflux; pfam01545 882094005554 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882094005555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 882094005556 PAS fold; Region: PAS_4; pfam08448 882094005557 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 882094005558 putative active site [active] 882094005559 heme pocket [chemical binding]; other site 882094005560 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 882094005561 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 882094005562 dimer interface [polypeptide binding]; other site 882094005563 putative CheW interface [polypeptide binding]; other site 882094005564 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 882094005565 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 882094005566 dimer interface [polypeptide binding]; other site 882094005567 active site 882094005568 Mn binding site [ion binding]; other site 882094005569 TRAM domain; Region: TRAM; cl01282 882094005570 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882094005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005572 S-adenosylmethionine binding site [chemical binding]; other site 882094005573 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 882094005574 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 882094005575 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 882094005576 Substrate-binding site [chemical binding]; other site 882094005577 Substrate specificity [chemical binding]; other site 882094005578 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 882094005579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 882094005580 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 882094005581 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 882094005582 active site 882094005583 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 882094005584 flavodoxin, short chain; Region: flav_short; TIGR01753 882094005585 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 882094005586 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 882094005587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094005588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094005589 putative substrate translocation pore; other site 882094005590 rod-share determining protein MreBH; Provisional; Region: PRK13929 882094005591 MreB and similar proteins; Region: MreB_like; cd10225 882094005592 nucleotide binding site [chemical binding]; other site 882094005593 Mg binding site [ion binding]; other site 882094005594 putative protofilament interaction site [polypeptide binding]; other site 882094005595 RodZ interaction site [polypeptide binding]; other site 882094005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005597 S-adenosylmethionine binding site [chemical binding]; other site 882094005598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094005599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094005600 Uncharacterized conserved protein [Function unknown]; Region: COG4748 882094005601 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 882094005602 Uncharacterized conserved protein [Function unknown]; Region: COG3589 882094005603 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 882094005604 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094005605 methionine cluster; other site 882094005606 active site 882094005607 phosphorylation site [posttranslational modification] 882094005608 metal binding site [ion binding]; metal-binding site 882094005609 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094005610 active site 882094005611 P-loop; other site 882094005612 phosphorylation site [posttranslational modification] 882094005613 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 882094005614 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094005615 Walker A motif; other site 882094005616 ATP binding site [chemical binding]; other site 882094005617 Walker B motif; other site 882094005618 arginine finger; other site 882094005619 Transcriptional antiterminator [Transcription]; Region: COG3933 882094005620 PRD domain; Region: PRD; pfam00874 882094005621 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094005622 active pocket/dimerization site; other site 882094005623 active site 882094005624 phosphorylation site [posttranslational modification] 882094005625 PRD domain; Region: PRD; pfam00874 882094005626 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882094005627 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882094005628 ATP binding site [chemical binding]; other site 882094005629 putative Mg++ binding site [ion binding]; other site 882094005630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094005631 nucleotide binding region [chemical binding]; other site 882094005632 ATP-binding site [chemical binding]; other site 882094005633 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882094005634 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094005635 Walker A/P-loop; other site 882094005636 ATP binding site [chemical binding]; other site 882094005637 Q-loop/lid; other site 882094005638 ABC transporter signature motif; other site 882094005639 Walker B; other site 882094005640 D-loop; other site 882094005641 H-loop/switch region; other site 882094005642 Predicted transcriptional regulators [Transcription]; Region: COG1725 882094005643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094005644 DNA-binding site [nucleotide binding]; DNA binding site 882094005645 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094005646 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094005647 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094005648 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094005649 DNA binding site [nucleotide binding] 882094005650 domain linker motif; other site 882094005651 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882094005652 dimerization interface [polypeptide binding]; other site 882094005653 ligand binding site [chemical binding]; other site 882094005654 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 882094005655 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882094005656 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882094005657 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882094005658 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882094005659 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094005660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094005661 dimer interface [polypeptide binding]; other site 882094005662 conserved gate region; other site 882094005663 putative PBP binding loops; other site 882094005664 ABC-ATPase subunit interface; other site 882094005665 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094005666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094005667 dimer interface [polypeptide binding]; other site 882094005668 conserved gate region; other site 882094005669 putative PBP binding loops; other site 882094005670 ABC-ATPase subunit interface; other site 882094005671 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 882094005672 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 882094005673 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 882094005674 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 882094005675 active site 882094005676 dimer interface [polypeptide binding]; other site 882094005677 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 882094005678 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 882094005679 active site 882094005680 FMN binding site [chemical binding]; other site 882094005681 substrate binding site [chemical binding]; other site 882094005682 3Fe-4S cluster binding site [ion binding]; other site 882094005683 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 882094005684 domain interface; other site 882094005685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094005686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094005687 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882094005688 putative dimerization interface [polypeptide binding]; other site 882094005689 Predicted acetyltransferase [General function prediction only]; Region: COG3153 882094005690 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 882094005691 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 882094005692 putative active site [active] 882094005693 metal binding site [ion binding]; metal-binding site 882094005694 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882094005695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882094005696 substrate binding pocket [chemical binding]; other site 882094005697 membrane-bound complex binding site; other site 882094005698 hinge residues; other site 882094005699 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094005700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094005701 Walker A/P-loop; other site 882094005702 ATP binding site [chemical binding]; other site 882094005703 Q-loop/lid; other site 882094005704 ABC transporter signature motif; other site 882094005705 Walker B; other site 882094005706 D-loop; other site 882094005707 H-loop/switch region; other site 882094005708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094005709 dimer interface [polypeptide binding]; other site 882094005710 conserved gate region; other site 882094005711 putative PBP binding loops; other site 882094005712 ABC-ATPase subunit interface; other site 882094005713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 882094005714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 882094005715 dimer interface [polypeptide binding]; other site 882094005716 phosphorylation site [posttranslational modification] 882094005717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094005718 ATP binding site [chemical binding]; other site 882094005719 Mg2+ binding site [ion binding]; other site 882094005720 G-X-G motif; other site 882094005721 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 882094005722 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882094005723 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 882094005724 active site 882094005725 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 882094005726 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 882094005727 putative NAD(P) binding site [chemical binding]; other site 882094005728 active site 882094005729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094005730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094005731 active site 882094005732 phosphorylation site [posttranslational modification] 882094005733 intermolecular recognition site; other site 882094005734 dimerization interface [polypeptide binding]; other site 882094005735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094005736 DNA binding site [nucleotide binding] 882094005737 FtsX-like permease family; Region: FtsX; pfam02687 882094005738 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882094005739 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094005740 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094005741 Walker A/P-loop; other site 882094005742 ATP binding site [chemical binding]; other site 882094005743 Q-loop/lid; other site 882094005744 ABC transporter signature motif; other site 882094005745 Walker B; other site 882094005746 D-loop; other site 882094005747 H-loop/switch region; other site 882094005748 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 882094005749 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 882094005750 ADP binding site [chemical binding]; other site 882094005751 magnesium binding site [ion binding]; other site 882094005752 putative shikimate binding site; other site 882094005753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 882094005754 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 882094005755 TRAM domain; Region: TRAM; pfam01938 882094005756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094005757 S-adenosylmethionine binding site [chemical binding]; other site 882094005758 putative lipid kinase; Reviewed; Region: PRK13337 882094005759 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882094005760 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 882094005761 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 882094005762 GatB domain; Region: GatB_Yqey; smart00845 882094005763 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 882094005764 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 882094005765 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 882094005766 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 882094005767 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 882094005768 putative dimer interface [polypeptide binding]; other site 882094005769 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 882094005770 putative dimer interface [polypeptide binding]; other site 882094005771 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 882094005772 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 882094005773 nucleotide binding pocket [chemical binding]; other site 882094005774 K-X-D-G motif; other site 882094005775 catalytic site [active] 882094005776 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 882094005777 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 882094005778 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 882094005779 Dimer interface [polypeptide binding]; other site 882094005780 BRCT sequence motif; other site 882094005781 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 882094005782 Part of AAA domain; Region: AAA_19; pfam13245 882094005783 Family description; Region: UvrD_C_2; pfam13538 882094005784 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 882094005785 PcrB family; Region: PcrB; pfam01884 882094005786 substrate binding site [chemical binding]; other site 882094005787 putative active site [active] 882094005788 dimer interface [polypeptide binding]; other site 882094005789 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 882094005790 Na2 binding site [ion binding]; other site 882094005791 putative substrate binding site 1 [chemical binding]; other site 882094005792 Na binding site 1 [ion binding]; other site 882094005793 putative substrate binding site 2 [chemical binding]; other site 882094005794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 882094005795 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 882094005796 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 882094005797 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 882094005798 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 882094005799 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 882094005800 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 882094005801 purine monophosphate binding site [chemical binding]; other site 882094005802 dimer interface [polypeptide binding]; other site 882094005803 putative catalytic residues [active] 882094005804 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 882094005805 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 882094005806 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 882094005807 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 882094005808 active site 882094005809 substrate binding site [chemical binding]; other site 882094005810 cosubstrate binding site; other site 882094005811 catalytic site [active] 882094005812 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 882094005813 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 882094005814 dimerization interface [polypeptide binding]; other site 882094005815 putative ATP binding site [chemical binding]; other site 882094005816 amidophosphoribosyltransferase; Provisional; Region: PRK06781 882094005817 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 882094005818 active site 882094005819 tetramer interface [polypeptide binding]; other site 882094005820 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094005821 active site 882094005822 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 882094005823 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 882094005824 dimerization interface [polypeptide binding]; other site 882094005825 ATP binding site [chemical binding]; other site 882094005826 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 882094005827 dimerization interface [polypeptide binding]; other site 882094005828 ATP binding site [chemical binding]; other site 882094005829 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 882094005830 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 882094005831 putative active site [active] 882094005832 catalytic triad [active] 882094005833 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 882094005834 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 882094005835 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 882094005836 ATP binding site [chemical binding]; other site 882094005837 active site 882094005838 substrate binding site [chemical binding]; other site 882094005839 adenylosuccinate lyase; Provisional; Region: PRK07492 882094005840 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 882094005841 tetramer interface [polypeptide binding]; other site 882094005842 active site 882094005843 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 882094005844 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 882094005845 NAD binding site [chemical binding]; other site 882094005846 ATP-grasp domain; Region: ATP-grasp; pfam02222 882094005847 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 882094005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 882094005849 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094005850 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 882094005851 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094005852 Zn2+ binding site [ion binding]; other site 882094005853 Mg2+ binding site [ion binding]; other site 882094005854 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882094005855 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882094005856 Walker A/P-loop; other site 882094005857 ATP binding site [chemical binding]; other site 882094005858 Q-loop/lid; other site 882094005859 ABC transporter signature motif; other site 882094005860 Walker B; other site 882094005861 D-loop; other site 882094005862 H-loop/switch region; other site 882094005863 peptidase T; Region: peptidase-T; TIGR01882 882094005864 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 882094005865 metal binding site [ion binding]; metal-binding site 882094005866 dimer interface [polypeptide binding]; other site 882094005867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 882094005868 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 882094005869 active site 882094005870 putative catalytic site [active] 882094005871 DNA binding site [nucleotide binding] 882094005872 putative phosphate binding site [ion binding]; other site 882094005873 metal binding site A [ion binding]; metal-binding site 882094005874 AP binding site [nucleotide binding]; other site 882094005875 metal binding site B [ion binding]; metal-binding site 882094005876 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 882094005877 23S rRNA binding site [nucleotide binding]; other site 882094005878 L21 binding site [polypeptide binding]; other site 882094005879 L13 binding site [polypeptide binding]; other site 882094005880 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 882094005881 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 882094005882 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 882094005883 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 882094005884 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094005885 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094005886 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094005887 Substrate binding site [chemical binding]; other site 882094005888 Leucine rich repeat; Region: LRR_8; pfam13855 882094005889 LRR adjacent; Region: LRR_adjacent; pfam08191 882094005890 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 882094005891 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 882094005892 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882094005893 DNA binding residues [nucleotide binding] 882094005894 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882094005895 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882094005896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094005897 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 882094005898 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 882094005899 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 882094005900 RimM N-terminal domain; Region: RimM; pfam01782 882094005901 PRC-barrel domain; Region: PRC; pfam05239 882094005902 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 882094005903 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 882094005904 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 882094005905 catalytic triad [active] 882094005906 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 882094005907 KH domain; Region: KH_4; pfam13083 882094005908 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 882094005909 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882094005910 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882094005911 signal recognition particle protein; Provisional; Region: PRK10867 882094005912 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 882094005913 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882094005914 P loop; other site 882094005915 GTP binding site [chemical binding]; other site 882094005916 Signal peptide binding domain; Region: SRP_SPB; pfam02978 882094005917 putative DNA-binding protein; Validated; Region: PRK00118 882094005918 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 882094005919 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 882094005920 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 882094005921 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 882094005922 P loop; other site 882094005923 GTP binding site [chemical binding]; other site 882094005924 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 882094005925 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882094005926 Walker A/P-loop; other site 882094005927 ATP binding site [chemical binding]; other site 882094005928 Q-loop/lid; other site 882094005929 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 882094005930 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 882094005931 linker region; other site 882094005932 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 882094005933 ABC transporter signature motif; other site 882094005934 Walker B; other site 882094005935 D-loop; other site 882094005936 H-loop/switch region; other site 882094005937 ribonuclease III; Reviewed; Region: rnc; PRK00102 882094005938 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 882094005939 dimerization interface [polypeptide binding]; other site 882094005940 active site 882094005941 metal binding site [ion binding]; metal-binding site 882094005942 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 882094005943 dsRNA binding site [nucleotide binding]; other site 882094005944 acyl carrier protein; Provisional; Region: acpP; PRK00982 882094005945 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882094005946 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 882094005947 NAD(P) binding site [chemical binding]; other site 882094005948 homotetramer interface [polypeptide binding]; other site 882094005949 homodimer interface [polypeptide binding]; other site 882094005950 active site 882094005951 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 882094005952 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 882094005953 putative phosphate acyltransferase; Provisional; Region: PRK05331 882094005954 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 882094005955 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 882094005956 active site 2 [active] 882094005957 active site 1 [active] 882094005958 Y-family of DNA polymerases; Region: PolY; cl12025 882094005959 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 882094005960 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 882094005961 generic binding surface II; other site 882094005962 ssDNA binding site; other site 882094005963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094005964 ATP binding site [chemical binding]; other site 882094005965 putative Mg++ binding site [ion binding]; other site 882094005966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094005967 nucleotide binding region [chemical binding]; other site 882094005968 ATP-binding site [chemical binding]; other site 882094005969 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 882094005970 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 882094005971 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 882094005972 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 882094005973 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 882094005974 putative L-serine binding site [chemical binding]; other site 882094005975 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 882094005976 DAK2 domain; Region: Dak2; pfam02734 882094005977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 882094005978 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 882094005979 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 882094005980 Thiamine pyrophosphokinase; Region: TPK; cd07995 882094005981 active site 882094005982 dimerization interface [polypeptide binding]; other site 882094005983 thiamine binding site [chemical binding]; other site 882094005984 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882094005985 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882094005986 substrate binding site [chemical binding]; other site 882094005987 hexamer interface [polypeptide binding]; other site 882094005988 metal binding site [ion binding]; metal-binding site 882094005989 GTPase RsgA; Reviewed; Region: PRK00098 882094005990 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 882094005991 RNA binding site [nucleotide binding]; other site 882094005992 homodimer interface [polypeptide binding]; other site 882094005993 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 882094005994 GTPase/Zn-binding domain interface [polypeptide binding]; other site 882094005995 GTP/Mg2+ binding site [chemical binding]; other site 882094005996 G4 box; other site 882094005997 G1 box; other site 882094005998 Switch I region; other site 882094005999 G2 box; other site 882094006000 G3 box; other site 882094006001 Switch II region; other site 882094006002 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 882094006003 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 882094006004 active site 882094006005 ATP binding site [chemical binding]; other site 882094006006 substrate binding site [chemical binding]; other site 882094006007 activation loop (A-loop); other site 882094006008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 882094006009 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882094006010 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882094006011 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 882094006012 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 882094006013 Protein phosphatase 2C; Region: PP2C; pfam00481 882094006014 active site 882094006015 16S rRNA methyltransferase B; Provisional; Region: PRK14902 882094006016 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 882094006017 putative RNA binding site [nucleotide binding]; other site 882094006018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094006019 S-adenosylmethionine binding site [chemical binding]; other site 882094006020 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 882094006021 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 882094006022 putative active site [active] 882094006023 substrate binding site [chemical binding]; other site 882094006024 putative cosubstrate binding site; other site 882094006025 catalytic site [active] 882094006026 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 882094006027 substrate binding site [chemical binding]; other site 882094006028 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 882094006029 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094006030 ATP binding site [chemical binding]; other site 882094006031 putative Mg++ binding site [ion binding]; other site 882094006032 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094006033 ATP-binding site [chemical binding]; other site 882094006034 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 882094006035 Flavoprotein; Region: Flavoprotein; pfam02441 882094006036 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 882094006037 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 882094006038 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 882094006039 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 882094006040 catalytic site [active] 882094006041 G-X2-G-X-G-K; other site 882094006042 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 882094006043 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 882094006044 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 882094006045 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 882094006046 Domain of unknown function (DUF814); Region: DUF814; pfam05670 882094006047 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 882094006048 putative NAD(P) binding site [chemical binding]; other site 882094006049 homodimer interface [polypeptide binding]; other site 882094006050 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094006051 active site 882094006052 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 882094006053 active site 882094006054 dimer interface [polypeptide binding]; other site 882094006055 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 882094006056 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 882094006057 heterodimer interface [polypeptide binding]; other site 882094006058 active site 882094006059 FMN binding site [chemical binding]; other site 882094006060 homodimer interface [polypeptide binding]; other site 882094006061 substrate binding site [chemical binding]; other site 882094006062 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 882094006063 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 882094006064 FAD binding pocket [chemical binding]; other site 882094006065 FAD binding motif [chemical binding]; other site 882094006066 phosphate binding motif [ion binding]; other site 882094006067 beta-alpha-beta structure motif; other site 882094006068 NAD binding pocket [chemical binding]; other site 882094006069 Iron coordination center [ion binding]; other site 882094006070 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 882094006071 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882094006072 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 882094006073 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 882094006074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 882094006075 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882094006076 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 882094006077 IMP binding site; other site 882094006078 dimer interface [polypeptide binding]; other site 882094006079 interdomain contacts; other site 882094006080 partial ornithine binding site; other site 882094006081 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 882094006082 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 882094006083 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 882094006084 catalytic site [active] 882094006085 subunit interface [polypeptide binding]; other site 882094006086 dihydroorotase; Validated; Region: pyrC; PRK09357 882094006087 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 882094006088 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 882094006089 active site 882094006090 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 882094006091 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 882094006092 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 882094006093 uracil transporter; Provisional; Region: PRK10720 882094006094 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 882094006095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094006096 active site 882094006097 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 882094006098 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882094006099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094006100 RNA binding surface [nucleotide binding]; other site 882094006101 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882094006102 active site 882094006103 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 882094006104 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882094006105 Sulfate transporter family; Region: Sulfate_transp; pfam00916 882094006106 multidrug efflux protein; Reviewed; Region: PRK01766 882094006107 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 882094006108 cation binding site [ion binding]; other site 882094006109 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 882094006110 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 882094006111 metal binding site [ion binding]; metal-binding site 882094006112 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 882094006113 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094006114 ABC-ATPase subunit interface; other site 882094006115 dimer interface [polypeptide binding]; other site 882094006116 putative PBP binding regions; other site 882094006117 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 882094006118 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 882094006119 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094006120 MarR family; Region: MarR; pfam01047 882094006121 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 882094006122 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 882094006123 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 882094006124 protein binding site [polypeptide binding]; other site 882094006125 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 882094006126 Catalytic dyad [active] 882094006127 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 882094006128 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882094006129 metal-binding site [ion binding] 882094006130 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 882094006131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 882094006132 metal-binding site [ion binding] 882094006133 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094006134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094006135 motif II; other site 882094006136 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 882094006137 putative homodimer interface [polypeptide binding]; other site 882094006138 putative homotetramer interface [polypeptide binding]; other site 882094006139 putative allosteric switch controlling residues; other site 882094006140 putative metal binding site [ion binding]; other site 882094006141 putative homodimer-homodimer interface [polypeptide binding]; other site 882094006142 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 882094006143 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 882094006144 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 882094006145 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 882094006146 hypothetical protein; Provisional; Region: PRK13672 882094006147 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094006148 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094006149 methionine sulfoxide reductase B; Provisional; Region: PRK00222 882094006150 SelR domain; Region: SelR; pfam01641 882094006151 methionine sulfoxide reductase A; Provisional; Region: PRK14054 882094006152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4698 882094006153 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 882094006154 active site 882094006155 catalytic triad [active] 882094006156 oxyanion hole [active] 882094006157 EDD domain protein, DegV family; Region: DegV; TIGR00762 882094006158 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882094006159 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 882094006160 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 882094006161 HTH domain; Region: HTH_11; pfam08279 882094006162 FOG: CBS domain [General function prediction only]; Region: COG0517 882094006163 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 882094006164 PEP synthetase regulatory protein; Provisional; Region: PRK05339 882094006165 pyruvate phosphate dikinase; Provisional; Region: PRK09279 882094006166 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 882094006167 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 882094006168 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 882094006169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094006170 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 882094006171 Predicted membrane protein [Function unknown]; Region: COG4129 882094006172 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 882094006173 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 882094006174 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 882094006175 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 882094006176 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 882094006177 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 882094006178 Clostridial hydrophobic, with a conserved W residue, domain; Region: ChW; smart00728 882094006179 Clostridial hydrophobic W; Region: ChW; pfam07538 882094006180 Clostridial hydrophobic W; Region: ChW; pfam07538 882094006181 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 882094006182 active site 882094006183 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 882094006184 substrate binding site [chemical binding]; other site 882094006185 metal binding site [ion binding]; metal-binding site 882094006186 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 882094006187 Methyltransferase domain; Region: Methyltransf_18; pfam12847 882094006188 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882094006189 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 882094006190 folate binding site [chemical binding]; other site 882094006191 NADP+ binding site [chemical binding]; other site 882094006192 thymidylate synthase; Region: thym_sym; TIGR03284 882094006193 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 882094006194 dimerization interface [polypeptide binding]; other site 882094006195 active site 882094006196 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882094006197 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882094006198 Walker A/P-loop; other site 882094006199 ATP binding site [chemical binding]; other site 882094006200 Q-loop/lid; other site 882094006201 ABC transporter signature motif; other site 882094006202 Walker B; other site 882094006203 D-loop; other site 882094006204 H-loop/switch region; other site 882094006205 ABC transporter; Region: ABC_tran_2; pfam12848 882094006206 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094006207 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 882094006208 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 882094006209 Potassium binding sites [ion binding]; other site 882094006210 Cesium cation binding sites [ion binding]; other site 882094006211 manganese transport transcriptional regulator; Provisional; Region: PRK03902 882094006212 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 882094006213 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 882094006214 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882094006215 DNA-binding site [nucleotide binding]; DNA binding site 882094006216 RNA-binding motif; other site 882094006217 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 882094006218 RNA/DNA hybrid binding site [nucleotide binding]; other site 882094006219 active site 882094006220 5'-3' exonuclease; Region: 53EXOc; smart00475 882094006221 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 882094006222 active site 882094006223 metal binding site 1 [ion binding]; metal-binding site 882094006224 putative 5' ssDNA interaction site; other site 882094006225 metal binding site 3; metal-binding site 882094006226 metal binding site 2 [ion binding]; metal-binding site 882094006227 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 882094006228 putative DNA binding site [nucleotide binding]; other site 882094006229 putative metal binding site [ion binding]; other site 882094006230 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 882094006231 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 882094006232 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 882094006233 putative active site [active] 882094006234 xanthine permease; Region: pbuX; TIGR03173 882094006235 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094006236 active site 882094006237 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 882094006238 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 882094006239 active site 882094006240 Zn binding site [ion binding]; other site 882094006241 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 882094006242 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 882094006243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 882094006244 cell division protein GpsB; Provisional; Region: PRK14127 882094006245 DivIVA domain; Region: DivI1A_domain; TIGR03544 882094006246 Interactor of ZYG-11; Region: ZYG-11_interact; pfam05884 882094006247 hypothetical protein; Provisional; Region: PRK13660 882094006248 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 882094006249 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 882094006250 Transglycosylase; Region: Transgly; pfam00912 882094006251 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882094006252 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882094006253 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 882094006254 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 882094006255 minor groove reading motif; other site 882094006256 helix-hairpin-helix signature motif; other site 882094006257 substrate binding pocket [chemical binding]; other site 882094006258 active site 882094006259 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 882094006260 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 882094006261 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 882094006262 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 882094006263 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 882094006264 putative dimer interface [polypeptide binding]; other site 882094006265 putative anticodon binding site; other site 882094006266 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 882094006267 homodimer interface [polypeptide binding]; other site 882094006268 motif 1; other site 882094006269 motif 2; other site 882094006270 active site 882094006271 motif 3; other site 882094006272 aspartate aminotransferase; Provisional; Region: PRK05764 882094006273 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094006274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094006275 homodimer interface [polypeptide binding]; other site 882094006276 catalytic residue [active] 882094006277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 882094006278 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 882094006279 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 882094006280 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 882094006281 active site 882094006282 catalytic site [active] 882094006283 substrate binding site [chemical binding]; other site 882094006284 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 882094006285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 882094006286 putative Mg++ binding site [ion binding]; other site 882094006287 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 882094006288 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 882094006289 tetramerization interface [polypeptide binding]; other site 882094006290 active site 882094006291 pantoate--beta-alanine ligase; Region: panC; TIGR00018 882094006292 Pantoate-beta-alanine ligase; Region: PanC; cd00560 882094006293 active site 882094006294 ATP-binding site [chemical binding]; other site 882094006295 pantoate-binding site; other site 882094006296 HXXH motif; other site 882094006297 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 882094006298 active site 882094006299 oligomerization interface [polypeptide binding]; other site 882094006300 metal binding site [ion binding]; metal-binding site 882094006301 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094006302 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882094006303 catalytic residues [active] 882094006304 Biotin operon repressor [Transcription]; Region: BirA; COG1654 882094006305 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 882094006306 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 882094006307 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 882094006308 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 882094006309 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 882094006310 active site 882094006311 NTP binding site [chemical binding]; other site 882094006312 metal binding triad [ion binding]; metal-binding site 882094006313 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 882094006314 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 882094006315 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 882094006316 active site 882094006317 dimer interfaces [polypeptide binding]; other site 882094006318 catalytic residues [active] 882094006319 dihydrodipicolinate reductase; Provisional; Region: PRK00048 882094006320 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 882094006321 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 882094006322 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 882094006323 homodimer interface [polypeptide binding]; other site 882094006324 metal binding site [ion binding]; metal-binding site 882094006325 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882094006326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094006327 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094006328 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094006329 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 882094006330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882094006331 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882094006332 metal binding site [ion binding]; metal-binding site 882094006333 active site 882094006334 I-site; other site 882094006335 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882094006336 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882094006337 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882094006338 metal binding site [ion binding]; metal-binding site 882094006339 active site 882094006340 I-site; other site 882094006341 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 882094006342 malate dehydrogenase; Provisional; Region: PRK13529 882094006343 Malic enzyme, N-terminal domain; Region: malic; pfam00390 882094006344 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 882094006345 NAD(P) binding pocket [chemical binding]; other site 882094006346 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 882094006347 Beta-lactamase; Region: Beta-lactamase; pfam00144 882094006348 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 882094006349 Pyruvate formate lyase 1; Region: PFL1; cd01678 882094006350 coenzyme A binding site [chemical binding]; other site 882094006351 active site 882094006352 catalytic residues [active] 882094006353 glycine loop; other site 882094006354 HI0933-like protein; Region: HI0933_like; pfam03486 882094006355 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094006356 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 882094006357 Predicted membrane protein [Function unknown]; Region: COG4347 882094006358 hypothetical protein; Provisional; Region: PRK03636 882094006359 UPF0302 domain; Region: UPF0302; pfam08864 882094006360 IDEAL domain; Region: IDEAL; pfam08858 882094006361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882094006362 binding surface 882094006363 TPR motif; other site 882094006364 TPR repeat; Region: TPR_11; pfam13414 882094006365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094006366 binding surface 882094006367 TPR motif; other site 882094006368 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 882094006369 binding surface 882094006370 TPR motif; other site 882094006371 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 882094006372 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 882094006373 hinge; other site 882094006374 active site 882094006375 prephenate dehydrogenase; Validated; Region: PRK06545 882094006376 prephenate dehydrogenase; Validated; Region: PRK08507 882094006377 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 882094006378 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 882094006379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094006380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094006381 homodimer interface [polypeptide binding]; other site 882094006382 catalytic residue [active] 882094006383 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 882094006384 homotrimer interaction site [polypeptide binding]; other site 882094006385 active site 882094006386 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 882094006387 active site 882094006388 dimer interface [polypeptide binding]; other site 882094006389 metal binding site [ion binding]; metal-binding site 882094006390 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 882094006391 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 882094006392 Tetramer interface [polypeptide binding]; other site 882094006393 active site 882094006394 FMN-binding site [chemical binding]; other site 882094006395 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 882094006396 active site 882094006397 multimer interface [polypeptide binding]; other site 882094006398 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882094006399 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882094006400 substrate binding pocket [chemical binding]; other site 882094006401 chain length determination region; other site 882094006402 substrate-Mg2+ binding site; other site 882094006403 catalytic residues [active] 882094006404 aspartate-rich region 1; other site 882094006405 active site lid residues [active] 882094006406 aspartate-rich region 2; other site 882094006407 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 882094006408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094006409 S-adenosylmethionine binding site [chemical binding]; other site 882094006410 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 882094006411 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 882094006412 homodecamer interface [polypeptide binding]; other site 882094006413 GTP cyclohydrolase I; Provisional; Region: PLN03044 882094006414 active site 882094006415 putative catalytic site residues [active] 882094006416 zinc binding site [ion binding]; other site 882094006417 GTP-CH-I/GFRP interaction surface; other site 882094006418 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 882094006419 IHF dimer interface [polypeptide binding]; other site 882094006420 IHF - DNA interface [nucleotide binding]; other site 882094006421 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 882094006422 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 882094006423 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 882094006424 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 882094006425 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 882094006426 GTP-binding protein Der; Reviewed; Region: PRK00093 882094006427 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 882094006428 G1 box; other site 882094006429 GTP/Mg2+ binding site [chemical binding]; other site 882094006430 Switch I region; other site 882094006431 G2 box; other site 882094006432 Switch II region; other site 882094006433 G3 box; other site 882094006434 G4 box; other site 882094006435 G5 box; other site 882094006436 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 882094006437 G1 box; other site 882094006438 GTP/Mg2+ binding site [chemical binding]; other site 882094006439 Switch I region; other site 882094006440 G2 box; other site 882094006441 G3 box; other site 882094006442 Switch II region; other site 882094006443 G4 box; other site 882094006444 G5 box; other site 882094006445 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 882094006446 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 882094006447 RNA binding site [nucleotide binding]; other site 882094006448 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 882094006449 RNA binding site [nucleotide binding]; other site 882094006450 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 882094006451 RNA binding site [nucleotide binding]; other site 882094006452 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882094006453 RNA binding site [nucleotide binding]; other site 882094006454 cytidylate kinase; Provisional; Region: cmk; PRK00023 882094006455 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 882094006456 CMP-binding site; other site 882094006457 The sites determining sugar specificity; other site 882094006458 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 882094006459 active site 882094006460 homotetramer interface [polypeptide binding]; other site 882094006461 homodimer interface [polypeptide binding]; other site 882094006462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094006463 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 882094006464 DEAD-like helicases superfamily; Region: DEXDc; smart00487 882094006465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094006466 ATP binding site [chemical binding]; other site 882094006467 putative Mg++ binding site [ion binding]; other site 882094006468 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094006469 nucleotide binding region [chemical binding]; other site 882094006470 ATP-binding site [chemical binding]; other site 882094006471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 882094006472 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006473 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006474 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006475 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006476 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006477 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006478 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 882094006479 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094006480 Predicted membrane protein [Function unknown]; Region: COG3601 882094006481 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882094006482 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 882094006483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094006484 dimerization interface [polypeptide binding]; other site 882094006485 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 882094006486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094006487 dimer interface [polypeptide binding]; other site 882094006488 phosphorylation site [posttranslational modification] 882094006489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094006490 ATP binding site [chemical binding]; other site 882094006491 Mg2+ binding site [ion binding]; other site 882094006492 G-X-G motif; other site 882094006493 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094006494 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094006495 active site 882094006496 phosphorylation site [posttranslational modification] 882094006497 intermolecular recognition site; other site 882094006498 dimerization interface [polypeptide binding]; other site 882094006499 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094006500 DNA binding site [nucleotide binding] 882094006501 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882094006502 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094006503 RNA binding surface [nucleotide binding]; other site 882094006504 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 882094006505 active site 882094006506 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 882094006507 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 882094006508 diaminopimelate decarboxylase; Region: lysA; TIGR01048 882094006509 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 882094006510 active site 882094006511 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882094006512 substrate binding site [chemical binding]; other site 882094006513 catalytic residues [active] 882094006514 dimer interface [polypeptide binding]; other site 882094006515 purine nucleoside phosphorylase; Provisional; Region: PRK08202 882094006516 phosphopentomutase; Provisional; Region: PRK05362 882094006517 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 882094006518 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 882094006519 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 882094006520 active site 882094006521 Int/Topo IB signature motif; other site 882094006522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 882094006523 metal binding site 2 [ion binding]; metal-binding site 882094006524 putative DNA binding helix; other site 882094006525 metal binding site 1 [ion binding]; metal-binding site 882094006526 dimer interface [polypeptide binding]; other site 882094006527 structural Zn2+ binding site [ion binding]; other site 882094006528 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882094006529 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094006530 ABC-ATPase subunit interface; other site 882094006531 dimer interface [polypeptide binding]; other site 882094006532 putative PBP binding regions; other site 882094006533 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882094006534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094006535 ABC-ATPase subunit interface; other site 882094006536 dimer interface [polypeptide binding]; other site 882094006537 putative PBP binding regions; other site 882094006538 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 882094006539 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 882094006540 putative ligand binding residues [chemical binding]; other site 882094006541 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882094006542 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882094006543 Walker A/P-loop; other site 882094006544 ATP binding site [chemical binding]; other site 882094006545 Q-loop/lid; other site 882094006546 ABC transporter signature motif; other site 882094006547 Walker B; other site 882094006548 D-loop; other site 882094006549 H-loop/switch region; other site 882094006550 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882094006551 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094006552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094006553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094006554 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 882094006555 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882094006556 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094006557 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094006558 Walker A/P-loop; other site 882094006559 ATP binding site [chemical binding]; other site 882094006560 Q-loop/lid; other site 882094006561 ABC transporter signature motif; other site 882094006562 Walker B; other site 882094006563 D-loop; other site 882094006564 H-loop/switch region; other site 882094006565 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 882094006566 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 882094006567 dimer interface [polypeptide binding]; other site 882094006568 ADP-ribose binding site [chemical binding]; other site 882094006569 active site 882094006570 nudix motif; other site 882094006571 metal binding site [ion binding]; metal-binding site 882094006572 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 882094006573 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 882094006574 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 882094006575 active site 882094006576 DNA polymerase IV; Validated; Region: PRK02406 882094006577 DNA binding site [nucleotide binding] 882094006578 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 882094006579 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 882094006580 NAD(P) binding site [chemical binding]; other site 882094006581 active site 882094006582 ribonuclease Z; Region: RNase_Z; TIGR02651 882094006583 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 882094006584 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 882094006585 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 882094006586 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 882094006587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882094006588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094006589 Coenzyme A binding pocket [chemical binding]; other site 882094006590 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 882094006591 6-phosphogluconate dehydratase; Region: edd; TIGR01196 882094006592 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 882094006593 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882094006594 PYR/PP interface [polypeptide binding]; other site 882094006595 dimer interface [polypeptide binding]; other site 882094006596 TPP binding site [chemical binding]; other site 882094006597 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882094006598 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 882094006599 TPP-binding site [chemical binding]; other site 882094006600 dimer interface [polypeptide binding]; other site 882094006601 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 882094006602 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 882094006603 putative valine binding site [chemical binding]; other site 882094006604 dimer interface [polypeptide binding]; other site 882094006605 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 882094006606 ketol-acid reductoisomerase; Provisional; Region: PRK05479 882094006607 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 882094006608 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 882094006609 2-isopropylmalate synthase; Validated; Region: PRK00915 882094006610 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 882094006611 active site 882094006612 catalytic residues [active] 882094006613 metal binding site [ion binding]; metal-binding site 882094006614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 882094006615 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 882094006616 tartrate dehydrogenase; Region: TTC; TIGR02089 882094006617 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 882094006618 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 882094006619 substrate binding site [chemical binding]; other site 882094006620 ligand binding site [chemical binding]; other site 882094006621 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 882094006622 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 882094006623 substrate binding site [chemical binding]; other site 882094006624 threonine dehydratase; Validated; Region: PRK08639 882094006625 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 882094006626 tetramer interface [polypeptide binding]; other site 882094006627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094006628 catalytic residue [active] 882094006629 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 882094006630 alpha-acetolactate decarboxylase; Region: acetolac_decarb; TIGR01252 882094006631 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 882094006632 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 882094006633 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 882094006634 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 882094006635 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094006636 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094006637 DNA binding site [nucleotide binding] 882094006638 domain linker motif; other site 882094006639 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882094006640 dimerization interface [polypeptide binding]; other site 882094006641 ligand binding site [chemical binding]; other site 882094006642 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 882094006643 intersubunit interface [polypeptide binding]; other site 882094006644 active site 882094006645 catalytic residue [active] 882094006646 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882094006647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 882094006648 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882094006649 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 882094006650 active pocket/dimerization site; other site 882094006651 active site 882094006652 phosphorylation site [posttranslational modification] 882094006653 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882094006654 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 882094006655 putative active site [active] 882094006656 SIS domain; Region: SIS; pfam01380 882094006657 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 882094006658 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 882094006659 dimer interface [polypeptide binding]; other site 882094006660 active site 882094006661 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 882094006662 dimer interface [polypeptide binding]; other site 882094006663 active site 882094006664 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 882094006665 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 882094006666 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 882094006667 active site 882094006668 phosphorylation site [posttranslational modification] 882094006669 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094006670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094006671 DNA-binding site [nucleotide binding]; DNA binding site 882094006672 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 882094006673 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094006674 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094006675 DNA-binding site [nucleotide binding]; DNA binding site 882094006676 UTRA domain; Region: UTRA; pfam07702 882094006677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094006678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094006679 active site 882094006680 catalytic tetrad [active] 882094006681 acetolactate synthase; Reviewed; Region: PRK08617 882094006682 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 882094006683 PYR/PP interface [polypeptide binding]; other site 882094006684 dimer interface [polypeptide binding]; other site 882094006685 TPP binding site [chemical binding]; other site 882094006686 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 882094006687 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 882094006688 TPP-binding site [chemical binding]; other site 882094006689 dimer interface [polypeptide binding]; other site 882094006690 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094006691 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 882094006692 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 882094006693 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094006694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094006695 dimer interface [polypeptide binding]; other site 882094006696 conserved gate region; other site 882094006697 ABC-ATPase subunit interface; other site 882094006698 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 882094006699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094006700 dimer interface [polypeptide binding]; other site 882094006701 conserved gate region; other site 882094006702 ABC-ATPase subunit interface; other site 882094006703 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 882094006704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094006705 active site 882094006706 phosphorylation site [posttranslational modification] 882094006707 intermolecular recognition site; other site 882094006708 dimerization interface [polypeptide binding]; other site 882094006709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094006710 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 882094006711 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 882094006712 dimerization interface [polypeptide binding]; other site 882094006713 Histidine kinase; Region: His_kinase; pfam06580 882094006714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094006715 ATP binding site [chemical binding]; other site 882094006716 Mg2+ binding site [ion binding]; other site 882094006717 G-X-G motif; other site 882094006718 Predicted integral membrane protein [Function unknown]; Region: COG5578 882094006719 Uncharacterized conserved protein [Function unknown]; Region: COG3538 882094006720 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 882094006721 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882094006722 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 882094006723 active site 882094006724 metal binding site [ion binding]; metal-binding site 882094006725 homodimer interface [polypeptide binding]; other site 882094006726 catalytic site [active] 882094006727 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882094006728 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 882094006729 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 882094006730 active site 882094006731 catalytic site [active] 882094006732 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 882094006733 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 882094006734 DNA-binding site [nucleotide binding]; DNA binding site 882094006735 RNA-binding motif; other site 882094006736 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 882094006737 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 882094006738 active site 882094006739 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 882094006740 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882094006741 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 882094006742 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 882094006743 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 882094006744 active site 882094006745 HIGH motif; other site 882094006746 nucleotide binding site [chemical binding]; other site 882094006747 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 882094006748 active site 882094006749 KMSKS motif; other site 882094006750 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 882094006751 tRNA binding surface [nucleotide binding]; other site 882094006752 anticodon binding site; other site 882094006753 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 882094006754 DivIVA protein; Region: DivIVA; pfam05103 882094006755 DivIVA domain; Region: DivI1A_domain; TIGR03544 882094006756 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 882094006757 HTH domain; Region: HTH_11; pfam08279 882094006758 3H domain; Region: 3H; pfam02829 882094006759 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 882094006760 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 882094006761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094006762 catalytic residue [active] 882094006763 L-aspartate oxidase; Provisional; Region: PRK08071 882094006764 L-aspartate oxidase; Provisional; Region: PRK06175 882094006765 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 882094006766 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 882094006767 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 882094006768 dimerization interface [polypeptide binding]; other site 882094006769 active site 882094006770 quinolinate synthetase; Provisional; Region: PRK09375 882094006771 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006772 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006773 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006774 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006775 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006776 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006777 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006778 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006779 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094006780 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006781 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006782 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006783 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006784 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006785 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006786 Leucine rich repeat; Region: LRR_8; pfam13855 882094006787 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094006788 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006789 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006790 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006791 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006792 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006793 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006794 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006795 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006796 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006797 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006798 Leucine rich repeat; Region: LRR_8; pfam13855 882094006799 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094006800 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006801 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006802 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006803 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006804 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006805 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006806 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 882094006807 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006808 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006809 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006810 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 882094006811 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 882094006812 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094006813 Methyltransferase domain; Region: Methyltransf_31; pfam13847 882094006814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094006815 S-adenosylmethionine binding site [chemical binding]; other site 882094006816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094006817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094006818 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 882094006819 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094006820 RNA binding surface [nucleotide binding]; other site 882094006821 YGGT family; Region: YGGT; pfam02325 882094006822 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 882094006823 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 882094006824 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 882094006825 catalytic residue [active] 882094006826 cell division protein FtsZ; Validated; Region: PRK09330 882094006827 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 882094006828 nucleotide binding site [chemical binding]; other site 882094006829 SulA interaction site; other site 882094006830 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 882094006831 Cell division protein FtsA; Region: FtsA; smart00842 882094006832 Cell division protein FtsA; Region: FtsA; pfam14450 882094006833 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 882094006834 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 882094006835 Cell division protein FtsQ; Region: FtsQ; pfam03799 882094006836 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 882094006837 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 882094006838 active site 882094006839 homodimer interface [polypeptide binding]; other site 882094006840 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 882094006841 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882094006842 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882094006843 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 882094006844 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 882094006845 Mg++ binding site [ion binding]; other site 882094006846 putative catalytic motif [active] 882094006847 putative substrate binding site [chemical binding]; other site 882094006848 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 882094006849 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 882094006850 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 882094006851 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 882094006852 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 882094006853 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 882094006854 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882094006855 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 882094006856 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 882094006857 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 882094006858 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 882094006859 MraW methylase family; Region: Methyltransf_5; pfam01795 882094006860 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 882094006861 MraZ protein; Region: MraZ; pfam02381 882094006862 MraZ protein; Region: MraZ; pfam02381 882094006863 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094006864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094006865 putative substrate translocation pore; other site 882094006866 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 882094006867 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 882094006868 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 882094006869 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 882094006870 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 882094006871 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 882094006872 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 882094006873 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 882094006874 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 882094006875 hypothetical protein; Provisional; Region: PRK13670 882094006876 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882094006877 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882094006878 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 882094006879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094006880 Walker A/P-loop; other site 882094006881 ATP binding site [chemical binding]; other site 882094006882 Q-loop/lid; other site 882094006883 ABC transporter signature motif; other site 882094006884 Walker B; other site 882094006885 D-loop; other site 882094006886 H-loop/switch region; other site 882094006887 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 882094006888 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 882094006889 protein binding site [polypeptide binding]; other site 882094006890 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 882094006891 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 882094006892 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 882094006893 active site 882094006894 (T/H)XGH motif; other site 882094006895 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 882094006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094006897 S-adenosylmethionine binding site [chemical binding]; other site 882094006898 hypothetical protein; Provisional; Region: PRK02886 882094006899 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 882094006900 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 882094006901 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 882094006902 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 882094006903 UbiA prenyltransferase family; Region: UbiA; pfam01040 882094006904 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 882094006905 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 882094006906 Ion transport protein; Region: Ion_trans; pfam00520 882094006907 Ion channel; Region: Ion_trans_2; pfam07885 882094006908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 882094006909 MOSC domain; Region: MOSC; pfam03473 882094006910 3-alpha domain; Region: 3-alpha; pfam03475 882094006911 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 882094006912 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 882094006913 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 882094006914 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 882094006915 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 882094006916 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 882094006917 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 882094006918 active site 882094006919 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 882094006920 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 882094006921 ring oligomerisation interface [polypeptide binding]; other site 882094006922 ATP/Mg binding site [chemical binding]; other site 882094006923 stacking interactions; other site 882094006924 hinge regions; other site 882094006925 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 882094006926 oligomerisation interface [polypeptide binding]; other site 882094006927 mobile loop; other site 882094006928 roof hairpin; other site 882094006929 CAAX protease self-immunity; Region: Abi; pfam02517 882094006930 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 882094006931 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 882094006932 CoA binding domain; Region: CoA_binding; pfam02629 882094006933 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882094006934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094006935 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094006936 ABC transporter; Region: ABC_tran_2; pfam12848 882094006937 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094006938 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094006939 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882094006940 UGMP family protein; Validated; Region: PRK09604 882094006941 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882094006942 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882094006943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094006944 Coenzyme A binding pocket [chemical binding]; other site 882094006945 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 882094006946 Glycoprotease family; Region: Peptidase_M22; pfam00814 882094006947 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 882094006948 camphor resistance protein CrcB; Provisional; Region: PRK14214 882094006949 camphor resistance protein CrcB; Provisional; Region: PRK14231 882094006950 Uncharacterized conserved protein [Function unknown]; Region: COG4832 882094006951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 882094006952 Phosphotransferase enzyme family; Region: APH; pfam01636 882094006953 active site 882094006954 substrate binding site [chemical binding]; other site 882094006955 ATP binding site [chemical binding]; other site 882094006956 Cna protein B-type domain; Region: Cna_B; pfam05738 882094006957 Cna protein B-type domain; Region: Cna_B; pfam05738 882094006958 Cna protein B-type domain; Region: Cna_B; pfam05738 882094006959 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094006960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094006961 non-specific DNA binding site [nucleotide binding]; other site 882094006962 salt bridge; other site 882094006963 sequence-specific DNA binding site [nucleotide binding]; other site 882094006964 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 882094006965 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882094006966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094006967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094006968 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 882094006969 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 882094006970 substrate binding pocket [chemical binding]; other site 882094006971 argininosuccinate synthase; Provisional; Region: PRK13820 882094006972 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 882094006973 ANP binding site [chemical binding]; other site 882094006974 Substrate Binding Site II [chemical binding]; other site 882094006975 Substrate Binding Site I [chemical binding]; other site 882094006976 argininosuccinate lyase; Provisional; Region: PRK00855 882094006977 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 882094006978 active sites [active] 882094006979 tetramer interface [polypeptide binding]; other site 882094006980 BCCT family transporter; Region: BCCT; pfam02028 882094006981 hypothetical protein; Provisional; Region: PRK06357 882094006982 active site 882094006983 intersubunit interface [polypeptide binding]; other site 882094006984 Zn2+ binding site [ion binding]; other site 882094006985 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882094006986 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882094006987 putative substrate binding site [chemical binding]; other site 882094006988 putative ATP binding site [chemical binding]; other site 882094006989 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882094006990 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882094006991 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882094006992 active site 882094006993 P-loop; other site 882094006994 phosphorylation site [posttranslational modification] 882094006995 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094006996 active site 882094006997 phosphorylation site [posttranslational modification] 882094006998 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094006999 PRD domain; Region: PRD; pfam00874 882094007000 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094007001 active site 882094007002 P-loop; other site 882094007003 phosphorylation site [posttranslational modification] 882094007004 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 882094007005 active site 882094007006 phosphorylation site [posttranslational modification] 882094007007 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 882094007008 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094007009 DNA-binding site [nucleotide binding]; DNA binding site 882094007010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094007011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094007012 homodimer interface [polypeptide binding]; other site 882094007013 catalytic residue [active] 882094007014 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 882094007015 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 882094007016 active site 882094007017 multimer interface [polypeptide binding]; other site 882094007018 glutamine amidotransferase subunit PdxT; Provisional; Region: PRK13525 882094007019 conserved cys residue [active] 882094007020 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 882094007021 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 882094007022 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 882094007023 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 882094007024 G1 box; other site 882094007025 GTP/Mg2+ binding site [chemical binding]; other site 882094007026 Switch I region; other site 882094007027 G2 box; other site 882094007028 G3 box; other site 882094007029 Switch II region; other site 882094007030 G4 box; other site 882094007031 G5 box; other site 882094007032 Nucleoside recognition; Region: Gate; pfam07670 882094007033 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 882094007034 Nucleoside recognition; Region: Gate; pfam07670 882094007035 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 882094007036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 882094007037 putative active site [active] 882094007038 putative metal binding site [ion binding]; other site 882094007039 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094007040 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882094007041 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094007042 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 882094007043 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 882094007044 active site 882094007045 dimer interface [polypeptide binding]; other site 882094007046 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882094007047 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882094007048 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 882094007049 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 882094007050 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 882094007051 dimer interface [polypeptide binding]; other site 882094007052 FMN binding site [chemical binding]; other site 882094007053 NADPH bind site [chemical binding]; other site 882094007054 Helix-turn-helix domain; Region: HTH_17; pfam12728 882094007055 putative heme peroxidase; Provisional; Region: PRK12276 882094007056 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094007057 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094007058 Walker A/P-loop; other site 882094007059 ATP binding site [chemical binding]; other site 882094007060 Q-loop/lid; other site 882094007061 ABC transporter signature motif; other site 882094007062 Walker B; other site 882094007063 D-loop; other site 882094007064 H-loop/switch region; other site 882094007065 FtsX-like permease family; Region: FtsX; pfam02687 882094007066 FtsX-like permease family; Region: FtsX; pfam02687 882094007067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094007068 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094007069 Coenzyme A binding pocket [chemical binding]; other site 882094007070 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 882094007071 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 882094007072 active site 882094007073 substrate binding site [chemical binding]; other site 882094007074 metal binding site [ion binding]; metal-binding site 882094007075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 882094007076 YbbR-like protein; Region: YbbR; pfam07949 882094007077 YbbR-like protein; Region: YbbR; pfam07949 882094007078 YbbR-like protein; Region: YbbR; pfam07949 882094007079 Uncharacterized conserved protein [Function unknown]; Region: COG1624 882094007080 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 882094007081 maltose phosphorylase; Provisional; Region: PRK13807 882094007082 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882094007083 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882094007084 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 882094007085 Predicted integral membrane protein [Function unknown]; Region: COG5521 882094007086 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094007087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007088 dimer interface [polypeptide binding]; other site 882094007089 conserved gate region; other site 882094007090 putative PBP binding loops; other site 882094007091 ABC-ATPase subunit interface; other site 882094007092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007093 dimer interface [polypeptide binding]; other site 882094007094 conserved gate region; other site 882094007095 putative PBP binding loops; other site 882094007096 ABC-ATPase subunit interface; other site 882094007097 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 882094007098 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094007099 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 882094007100 homodimer interface [polypeptide binding]; other site 882094007101 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 882094007102 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 882094007103 active site 882094007104 homodimer interface [polypeptide binding]; other site 882094007105 catalytic site [active] 882094007106 CAAX protease self-immunity; Region: Abi; cl00558 882094007107 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094007108 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094007109 DNA binding site [nucleotide binding] 882094007110 domain linker motif; other site 882094007111 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 882094007112 ligand binding site [chemical binding]; other site 882094007113 dimerization interface [polypeptide binding]; other site 882094007114 Amino acid permease; Region: AA_permease_2; pfam13520 882094007115 K+ potassium transporter; Region: K_trans; cl15781 882094007116 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094007117 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094007118 ligand binding site [chemical binding]; other site 882094007119 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094007120 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094007121 ligand binding site [chemical binding]; other site 882094007122 flexible hinge region; other site 882094007123 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094007124 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882094007125 intersubunit interface [polypeptide binding]; other site 882094007126 active site 882094007127 zinc binding site [ion binding]; other site 882094007128 Na+ binding site [ion binding]; other site 882094007129 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882094007130 intersubunit interface [polypeptide binding]; other site 882094007131 active site 882094007132 zinc binding site [ion binding]; other site 882094007133 Na+ binding site [ion binding]; other site 882094007134 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094007135 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094007136 active site 882094007137 P-loop; other site 882094007138 phosphorylation site [posttranslational modification] 882094007139 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094007140 active site 882094007141 phosphorylation site [posttranslational modification] 882094007142 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094007143 HTH domain; Region: HTH_11; pfam08279 882094007144 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094007145 PRD domain; Region: PRD; pfam00874 882094007146 PRD domain; Region: PRD; pfam00874 882094007147 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094007148 active site 882094007149 P-loop; other site 882094007150 phosphorylation site [posttranslational modification] 882094007151 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 882094007152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094007153 Walker A/P-loop; other site 882094007154 ATP binding site [chemical binding]; other site 882094007155 Q-loop/lid; other site 882094007156 ABC transporter signature motif; other site 882094007157 Walker B; other site 882094007158 D-loop; other site 882094007159 H-loop/switch region; other site 882094007160 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 882094007161 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 882094007162 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 882094007163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094007164 Coenzyme A binding pocket [chemical binding]; other site 882094007165 Transcriptional regulators [Transcription]; Region: GntR; COG1802 882094007166 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 882094007167 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 882094007168 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 882094007169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094007170 DNA-binding site [nucleotide binding]; DNA binding site 882094007171 UTRA domain; Region: UTRA; pfam07702 882094007172 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 882094007173 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 882094007174 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094007175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094007176 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 882094007177 putative dimerization interface [polypeptide binding]; other site 882094007178 Predicted membrane protein [Function unknown]; Region: COG2855 882094007179 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 882094007180 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 882094007181 putative metal binding site [ion binding]; other site 882094007182 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 882094007183 homodimer interface [polypeptide binding]; other site 882094007184 chemical substrate binding site [chemical binding]; other site 882094007185 oligomer interface [polypeptide binding]; other site 882094007186 metal binding site [ion binding]; metal-binding site 882094007187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094007188 catalytic residues [active] 882094007189 flavodoxin; Provisional; Region: PRK09271 882094007190 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 882094007191 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 882094007192 dimer interface [polypeptide binding]; other site 882094007193 putative radical transfer pathway; other site 882094007194 diiron center [ion binding]; other site 882094007195 tyrosyl radical; other site 882094007196 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 882094007197 Class I ribonucleotide reductase; Region: RNR_I; cd01679 882094007198 active site 882094007199 dimer interface [polypeptide binding]; other site 882094007200 catalytic residues [active] 882094007201 effector binding site; other site 882094007202 R2 peptide binding site; other site 882094007203 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 882094007204 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 882094007205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 882094007206 SCP-2 sterol transfer family; Region: SCP2; cl01225 882094007207 CsbD-like; Region: CsbD; cl17424 882094007208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094007209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094007210 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882094007211 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882094007212 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 882094007213 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 882094007214 conserved cys residue [active] 882094007215 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882094007216 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094007217 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094007218 Cupin; Region: Cupin_1; pfam00190 882094007219 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094007220 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094007221 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094007222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094007223 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094007224 ligand binding site [chemical binding]; other site 882094007225 flexible hinge region; other site 882094007226 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 882094007227 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 882094007228 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094007229 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 882094007230 dimer interface [polypeptide binding]; other site 882094007231 active site 882094007232 metal binding site [ion binding]; metal-binding site 882094007233 glutathione binding site [chemical binding]; other site 882094007234 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 882094007235 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 882094007236 FMN binding site [chemical binding]; other site 882094007237 substrate binding site [chemical binding]; other site 882094007238 putative catalytic residue [active] 882094007239 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 882094007240 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 882094007241 Coenzyme A transferase; Region: CoA_trans; smart00882 882094007242 Coenzyme A transferase; Region: CoA_trans; cl17247 882094007243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094007244 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 882094007245 Walker A motif; other site 882094007246 ATP binding site [chemical binding]; other site 882094007247 Walker B motif; other site 882094007248 arginine finger; other site 882094007249 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 882094007250 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 882094007251 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 882094007252 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 882094007253 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 882094007254 metal binding site [ion binding]; metal-binding site 882094007255 active site 882094007256 I-site; other site 882094007257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 882094007258 classical (c) SDRs; Region: SDR_c; cd05233 882094007259 NAD(P) binding site [chemical binding]; other site 882094007260 active site 882094007261 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 882094007262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094007263 Tic20-like protein; Region: Tic20; pfam09685 882094007264 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882094007265 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007266 Collagen binding domain; Region: Collagen_bind; pfam05737 882094007267 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007268 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007269 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007270 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007271 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 882094007272 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007273 Collagen binding domain; Region: Collagen_bind; pfam05737 882094007274 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007275 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007276 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007277 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007278 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007279 Cna protein B-type domain; Region: Cna_B; pfam05738 882094007280 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007281 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094007282 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007283 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007284 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094007285 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 882094007286 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 882094007287 active site 882094007288 catalytic site [active] 882094007289 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882094007290 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882094007291 Walker A/P-loop; other site 882094007292 ATP binding site [chemical binding]; other site 882094007293 Q-loop/lid; other site 882094007294 ABC transporter signature motif; other site 882094007295 Walker B; other site 882094007296 D-loop; other site 882094007297 H-loop/switch region; other site 882094007298 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 882094007299 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094007300 ABC-ATPase subunit interface; other site 882094007301 dimer interface [polypeptide binding]; other site 882094007302 putative PBP binding regions; other site 882094007303 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 882094007304 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882094007305 intersubunit interface [polypeptide binding]; other site 882094007306 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882094007307 heme-binding site [chemical binding]; other site 882094007308 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 882094007309 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882094007310 heme-binding site [chemical binding]; other site 882094007311 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882094007312 heme-binding site [chemical binding]; other site 882094007313 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882094007314 heme uptake protein IsdC; Region: IsdC; TIGR03656 882094007315 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 882094007316 heme-binding site [chemical binding]; other site 882094007317 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 882094007318 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 882094007319 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 882094007320 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 882094007321 active site 882094007322 Zn binding site [ion binding]; other site 882094007323 Competence protein CoiA-like family; Region: CoiA; cl11541 882094007324 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 882094007325 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 882094007326 ArsC family; Region: ArsC; pfam03960 882094007327 putative catalytic residues [active] 882094007328 thiol/disulfide switch; other site 882094007329 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 882094007330 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882094007331 Walker A/P-loop; other site 882094007332 ATP binding site [chemical binding]; other site 882094007333 Q-loop/lid; other site 882094007334 ABC transporter signature motif; other site 882094007335 Walker B; other site 882094007336 D-loop; other site 882094007337 H-loop/switch region; other site 882094007338 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882094007339 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 882094007340 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 882094007341 Walker A/P-loop; other site 882094007342 ATP binding site [chemical binding]; other site 882094007343 Q-loop/lid; other site 882094007344 ABC transporter signature motif; other site 882094007345 Walker B; other site 882094007346 D-loop; other site 882094007347 H-loop/switch region; other site 882094007348 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 882094007349 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 882094007350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007351 dimer interface [polypeptide binding]; other site 882094007352 conserved gate region; other site 882094007353 putative PBP binding loops; other site 882094007354 ABC-ATPase subunit interface; other site 882094007355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 882094007356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007357 dimer interface [polypeptide binding]; other site 882094007358 conserved gate region; other site 882094007359 putative PBP binding loops; other site 882094007360 ABC-ATPase subunit interface; other site 882094007361 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882094007362 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882094007363 peptide binding site [polypeptide binding]; other site 882094007364 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 882094007365 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 882094007366 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 882094007367 active site 882094007368 HIGH motif; other site 882094007369 dimer interface [polypeptide binding]; other site 882094007370 KMSKS motif; other site 882094007371 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 882094007372 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094007373 MarR family; Region: MarR; pfam01047 882094007374 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 882094007375 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 882094007376 dimer interface [polypeptide binding]; other site 882094007377 active site 882094007378 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 882094007379 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 882094007380 dimer interface [polypeptide binding]; other site 882094007381 active site 882094007382 CoA binding pocket [chemical binding]; other site 882094007383 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094007384 SH3-like domain; Region: SH3_8; pfam13457 882094007385 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 882094007386 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094007387 catalytic core [active] 882094007388 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 882094007389 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 882094007390 Clp amino terminal domain; Region: Clp_N; pfam02861 882094007391 Clp amino terminal domain; Region: Clp_N; pfam02861 882094007392 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094007393 Walker A motif; other site 882094007394 ATP binding site [chemical binding]; other site 882094007395 Walker B motif; other site 882094007396 arginine finger; other site 882094007397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094007398 Walker A motif; other site 882094007399 ATP binding site [chemical binding]; other site 882094007400 Walker B motif; other site 882094007401 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 882094007402 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 882094007403 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 882094007404 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094007405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094007406 active site 882094007407 motif I; other site 882094007408 motif II; other site 882094007409 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882094007410 Predicted acetyltransferase [General function prediction only]; Region: COG3393 882094007411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 882094007412 ferrochelatase; Provisional; Region: PRK12435 882094007413 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 882094007414 C-terminal domain interface [polypeptide binding]; other site 882094007415 active site 882094007416 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 882094007417 active site 882094007418 N-terminal domain interface [polypeptide binding]; other site 882094007419 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 882094007420 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 882094007421 substrate binding site [chemical binding]; other site 882094007422 active site 882094007423 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 882094007424 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 882094007425 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882094007426 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094007427 Walker A/P-loop; other site 882094007428 ATP binding site [chemical binding]; other site 882094007429 Q-loop/lid; other site 882094007430 ABC transporter signature motif; other site 882094007431 Walker B; other site 882094007432 D-loop; other site 882094007433 H-loop/switch region; other site 882094007434 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 882094007435 HIT family signature motif; other site 882094007436 catalytic residue [active] 882094007437 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 882094007438 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 882094007439 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 882094007440 SurA N-terminal domain; Region: SurA_N_3; cl07813 882094007441 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 882094007442 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 882094007443 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 882094007444 generic binding surface II; other site 882094007445 generic binding surface I; other site 882094007446 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094007447 Zn2+ binding site [ion binding]; other site 882094007448 Mg2+ binding site [ion binding]; other site 882094007449 Uncharacterized conserved protein [Function unknown]; Region: COG4717 882094007450 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 882094007451 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 882094007452 active site 882094007453 metal binding site [ion binding]; metal-binding site 882094007454 DNA binding site [nucleotide binding] 882094007455 hypothetical protein; Provisional; Region: PRK13676 882094007456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 882094007457 fumarate hydratase; Reviewed; Region: fumC; PRK00485 882094007458 Class II fumarases; Region: Fumarase_classII; cd01362 882094007459 active site 882094007460 tetramer interface [polypeptide binding]; other site 882094007461 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 882094007462 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094007463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094007464 Walker A/P-loop; other site 882094007465 ATP binding site [chemical binding]; other site 882094007466 Q-loop/lid; other site 882094007467 ABC transporter signature motif; other site 882094007468 Walker B; other site 882094007469 D-loop; other site 882094007470 H-loop/switch region; other site 882094007471 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882094007472 Transglycosylase; Region: Transgly; pfam00912 882094007473 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 882094007474 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 882094007475 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882094007476 Low molecular weight phosphatase family; Region: LMWPc; cl00105 882094007477 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882094007478 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882094007479 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882094007480 Domain of unknown function DUF21; Region: DUF21; pfam01595 882094007481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882094007482 Transporter associated domain; Region: CorC_HlyC; smart01091 882094007483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094007484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094007485 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 882094007486 putative dimerization interface [polypeptide binding]; other site 882094007487 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 882094007488 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 882094007489 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 882094007490 active site 882094007491 FMN binding site [chemical binding]; other site 882094007492 substrate binding site [chemical binding]; other site 882094007493 putative catalytic residue [active] 882094007494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094007495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094007496 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 882094007497 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 882094007498 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 882094007499 shikimate binding site; other site 882094007500 NAD(P) binding site [chemical binding]; other site 882094007501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094007502 putative substrate translocation pore; other site 882094007503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094007504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094007505 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094007506 putative substrate translocation pore; other site 882094007507 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 882094007508 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094007509 Walker A/P-loop; other site 882094007510 ATP binding site [chemical binding]; other site 882094007511 Q-loop/lid; other site 882094007512 ABC transporter signature motif; other site 882094007513 Walker B; other site 882094007514 D-loop; other site 882094007515 H-loop/switch region; other site 882094007516 Predicted transcriptional regulators [Transcription]; Region: COG1725 882094007517 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 882094007518 DNA-binding site [nucleotide binding]; DNA binding site 882094007519 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 882094007520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 882094007521 DNA binding site [nucleotide binding] 882094007522 active site 882094007523 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 882094007524 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 882094007525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094007526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094007527 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 882094007528 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 882094007529 active site 882094007530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 882094007531 putative dimer interface [polypeptide binding]; other site 882094007532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094007533 ligand binding site [chemical binding]; other site 882094007534 Zn binding site [ion binding]; other site 882094007535 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 882094007536 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 882094007537 active site 882094007538 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094007539 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094007540 active site 882094007541 catalytic tetrad [active] 882094007542 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 882094007543 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 882094007544 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882094007545 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882094007546 substrate binding pocket [chemical binding]; other site 882094007547 membrane-bound complex binding site; other site 882094007548 hinge residues; other site 882094007549 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882094007550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007551 dimer interface [polypeptide binding]; other site 882094007552 conserved gate region; other site 882094007553 putative PBP binding loops; other site 882094007554 ABC-ATPase subunit interface; other site 882094007555 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882094007556 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882094007557 Walker A/P-loop; other site 882094007558 ATP binding site [chemical binding]; other site 882094007559 Q-loop/lid; other site 882094007560 ABC transporter signature motif; other site 882094007561 Walker B; other site 882094007562 D-loop; other site 882094007563 H-loop/switch region; other site 882094007564 aspartate aminotransferase; Provisional; Region: PRK06348 882094007565 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094007566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094007567 homodimer interface [polypeptide binding]; other site 882094007568 catalytic residue [active] 882094007569 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882094007570 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882094007571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094007572 motif II; other site 882094007573 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 882094007574 intracellular protease, PfpI family; Region: PfpI; TIGR01382 882094007575 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 882094007576 proposed catalytic triad [active] 882094007577 conserved cys residue [active] 882094007578 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 882094007579 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094007580 methionine cluster; other site 882094007581 active site 882094007582 phosphorylation site [posttranslational modification] 882094007583 metal binding site [ion binding]; metal-binding site 882094007584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094007585 Coenzyme A binding pocket [chemical binding]; other site 882094007586 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094007587 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 882094007588 esterase; Provisional; Region: PRK10566 882094007589 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882094007590 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094007591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882094007592 motif II; other site 882094007593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094007594 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882094007595 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094007596 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094007597 hypothetical protein; Provisional; Region: PRK13673 882094007598 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 882094007599 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 882094007600 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 882094007601 Part of AAA domain; Region: AAA_19; pfam13245 882094007602 Family description; Region: UvrD_C_2; pfam13538 882094007603 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882094007604 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 882094007605 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 882094007606 IDEAL domain; Region: IDEAL; pfam08858 882094007607 ComK protein; Region: ComK; cl11560 882094007608 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 882094007609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094007610 non-specific DNA binding site [nucleotide binding]; other site 882094007611 salt bridge; other site 882094007612 sequence-specific DNA binding site [nucleotide binding]; other site 882094007613 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882094007614 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094007615 active site 882094007616 phosphorylation site [posttranslational modification] 882094007617 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094007618 active site 882094007619 P-loop; other site 882094007620 phosphorylation site [posttranslational modification] 882094007621 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094007622 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 882094007623 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 882094007624 putative substrate binding site [chemical binding]; other site 882094007625 putative ATP binding site [chemical binding]; other site 882094007626 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094007627 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882094007628 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094007629 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 882094007630 trimer interface [polypeptide binding]; other site 882094007631 active site 882094007632 G bulge; other site 882094007633 Uncharacterized conserved protein [Function unknown]; Region: COG1683 882094007634 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 882094007635 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 882094007636 non-specific DNA interactions [nucleotide binding]; other site 882094007637 DNA binding site [nucleotide binding] 882094007638 sequence specific DNA binding site [nucleotide binding]; other site 882094007639 putative cAMP binding site [chemical binding]; other site 882094007640 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 882094007641 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 882094007642 substrate binding site [chemical binding]; other site 882094007643 ATP binding site [chemical binding]; other site 882094007644 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 882094007645 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 882094007646 RNA binding surface [nucleotide binding]; other site 882094007647 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 882094007648 active site 882094007649 uracil binding [chemical binding]; other site 882094007650 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 882094007651 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 882094007652 active site 882094007653 non-prolyl cis peptide bond; other site 882094007654 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 882094007655 catalytic residues [active] 882094007656 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 882094007657 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 882094007658 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 882094007659 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 882094007660 Walker A/P-loop; other site 882094007661 ATP binding site [chemical binding]; other site 882094007662 Q-loop/lid; other site 882094007663 ABC transporter signature motif; other site 882094007664 Walker B; other site 882094007665 D-loop; other site 882094007666 H-loop/switch region; other site 882094007667 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882094007668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007669 dimer interface [polypeptide binding]; other site 882094007670 conserved gate region; other site 882094007671 putative PBP binding loops; other site 882094007672 ABC-ATPase subunit interface; other site 882094007673 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 882094007674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007675 dimer interface [polypeptide binding]; other site 882094007676 conserved gate region; other site 882094007677 putative PBP binding loops; other site 882094007678 ABC-ATPase subunit interface; other site 882094007679 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 882094007680 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 882094007681 substrate binding pocket [chemical binding]; other site 882094007682 membrane-bound complex binding site; other site 882094007683 hinge residues; other site 882094007684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094007685 Coenzyme A binding pocket [chemical binding]; other site 882094007686 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 882094007687 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 882094007688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 882094007689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 882094007690 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 882094007691 dimerization interface [polypeptide binding]; other site 882094007692 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 882094007693 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 882094007694 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 882094007695 active site 882094007696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094007697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094007698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094007699 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 882094007700 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882094007701 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882094007702 active site 882094007703 trimer interface [polypeptide binding]; other site 882094007704 allosteric site; other site 882094007705 active site lid [active] 882094007706 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882094007707 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094007708 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 882094007709 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 882094007710 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 882094007711 NAD binding site [chemical binding]; other site 882094007712 sugar binding site [chemical binding]; other site 882094007713 divalent metal binding site [ion binding]; other site 882094007714 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094007715 dimer interface [polypeptide binding]; other site 882094007716 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094007717 HTH domain; Region: HTH_11; pfam08279 882094007718 PRD domain; Region: PRD; pfam00874 882094007719 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094007720 active site 882094007721 phosphorylation site [posttranslational modification] 882094007722 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 882094007723 putative active site [active] 882094007724 YdjC motif; other site 882094007725 Mg binding site [ion binding]; other site 882094007726 putative homodimer interface [polypeptide binding]; other site 882094007727 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094007728 methionine cluster; other site 882094007729 active site 882094007730 phosphorylation site [posttranslational modification] 882094007731 metal binding site [ion binding]; metal-binding site 882094007732 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094007733 active site 882094007734 P-loop; other site 882094007735 phosphorylation site [posttranslational modification] 882094007736 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094007737 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094007738 Predicted membrane protein [Function unknown]; Region: COG1511 882094007739 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 882094007740 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 882094007741 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 882094007742 Predicted transcriptional regulator [Transcription]; Region: COG1959 882094007743 Transcriptional regulator; Region: Rrf2; pfam02082 882094007744 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 882094007745 L-tyrosine decarboxylase; Provisional; Region: PRK13520 882094007746 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882094007747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094007748 catalytic residue [active] 882094007749 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 882094007750 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094007751 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 882094007752 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 882094007753 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 882094007754 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 882094007755 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 882094007756 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 882094007757 active site 882094007758 dimer interface [polypeptide binding]; other site 882094007759 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 882094007760 dimer interface [polypeptide binding]; other site 882094007761 active site 882094007762 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 882094007763 nudix motif; other site 882094007764 general stress protein 13; Validated; Region: PRK08059 882094007765 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 882094007766 RNA binding site [nucleotide binding]; other site 882094007767 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 882094007768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 882094007769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094007770 homodimer interface [polypeptide binding]; other site 882094007771 catalytic residue [active] 882094007772 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 882094007773 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094007774 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094007775 Walker A/P-loop; other site 882094007776 ATP binding site [chemical binding]; other site 882094007777 Q-loop/lid; other site 882094007778 ABC transporter signature motif; other site 882094007779 Walker B; other site 882094007780 D-loop; other site 882094007781 H-loop/switch region; other site 882094007782 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094007783 active site 882094007784 P-loop; other site 882094007785 phosphorylation site [posttranslational modification] 882094007786 aspartate kinase; Reviewed; Region: PRK09034 882094007787 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 882094007788 putative catalytic residues [active] 882094007789 putative nucleotide binding site [chemical binding]; other site 882094007790 putative aspartate binding site [chemical binding]; other site 882094007791 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 882094007792 allosteric regulatory residue; other site 882094007793 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 882094007794 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 882094007795 putative active site [active] 882094007796 putative NTP binding site [chemical binding]; other site 882094007797 putative nucleic acid binding site [nucleotide binding]; other site 882094007798 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 882094007799 active site 882094007800 drug efflux system protein MdtG; Provisional; Region: PRK09874 882094007801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094007802 putative substrate translocation pore; other site 882094007803 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 882094007804 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882094007805 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 882094007806 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 882094007807 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 882094007808 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 882094007809 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 882094007810 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 882094007811 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 882094007812 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 882094007813 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 882094007814 CoenzymeA binding site [chemical binding]; other site 882094007815 subunit interaction site [polypeptide binding]; other site 882094007816 PHB binding site; other site 882094007817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 882094007818 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 882094007819 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 882094007820 Cl- selectivity filter; other site 882094007821 Cl- binding residues [ion binding]; other site 882094007822 pore gating glutamate residue; other site 882094007823 dimer interface [polypeptide binding]; other site 882094007824 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094007825 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 882094007826 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882094007827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094007828 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 882094007829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094007830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094007831 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 882094007832 NADH(P)-binding; Region: NAD_binding_10; pfam13460 882094007833 NAD(P) binding site [chemical binding]; other site 882094007834 putative active site [active] 882094007835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4844 882094007836 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 882094007837 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094007838 Leucine-rich repeats; other site 882094007839 Substrate binding site [chemical binding]; other site 882094007840 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094007841 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094007842 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094007843 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007844 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007845 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007846 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007847 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007848 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094007849 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 882094007850 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 882094007851 tetramer interfaces [polypeptide binding]; other site 882094007852 binuclear metal-binding site [ion binding]; other site 882094007853 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882094007854 Domain of unknown function DUF21; Region: DUF21; pfam01595 882094007855 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882094007856 Transporter associated domain; Region: CorC_HlyC; smart01091 882094007857 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 882094007858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094007859 Coenzyme A binding pocket [chemical binding]; other site 882094007860 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 882094007861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094007862 active site 882094007863 motif I; other site 882094007864 motif II; other site 882094007865 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094007866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 882094007867 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 882094007868 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 882094007869 active site 882094007870 metal binding site [ion binding]; metal-binding site 882094007871 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 882094007872 Predicted permeases [General function prediction only]; Region: COG0730 882094007873 Predicted membrane protein [Function unknown]; Region: COG4272 882094007874 Uncharacterized conserved protein [Function unknown]; Region: COG1801 882094007875 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 882094007876 FeS assembly protein SufB; Region: sufB; TIGR01980 882094007877 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 882094007878 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 882094007879 trimerization site [polypeptide binding]; other site 882094007880 active site 882094007881 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 882094007882 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 882094007883 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094007884 catalytic residue [active] 882094007885 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 882094007886 FeS assembly protein SufD; Region: sufD; TIGR01981 882094007887 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 882094007888 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 882094007889 Walker A/P-loop; other site 882094007890 ATP binding site [chemical binding]; other site 882094007891 Q-loop/lid; other site 882094007892 ABC transporter signature motif; other site 882094007893 Walker B; other site 882094007894 D-loop; other site 882094007895 H-loop/switch region; other site 882094007896 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 882094007897 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 882094007898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094007899 ABC-ATPase subunit interface; other site 882094007900 putative PBP binding loops; other site 882094007901 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 882094007902 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 882094007903 Walker A/P-loop; other site 882094007904 ATP binding site [chemical binding]; other site 882094007905 Q-loop/lid; other site 882094007906 ABC transporter signature motif; other site 882094007907 Walker B; other site 882094007908 D-loop; other site 882094007909 H-loop/switch region; other site 882094007910 NIL domain; Region: NIL; pfam09383 882094007911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094007912 dimer interface [polypeptide binding]; other site 882094007913 phosphorylation site [posttranslational modification] 882094007914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094007915 ATP binding site [chemical binding]; other site 882094007916 Mg2+ binding site [ion binding]; other site 882094007917 G-X-G motif; other site 882094007918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094007919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094007920 active site 882094007921 phosphorylation site [posttranslational modification] 882094007922 intermolecular recognition site; other site 882094007923 dimerization interface [polypeptide binding]; other site 882094007924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094007925 DNA binding site [nucleotide binding] 882094007926 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882094007927 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 882094007928 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094007929 catalytic residues [active] 882094007930 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 882094007931 lipoyl attachment site [posttranslational modification]; other site 882094007932 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 882094007933 ArsC family; Region: ArsC; pfam03960 882094007934 putative ArsC-like catalytic residues; other site 882094007935 putative TRX-like catalytic residues [active] 882094007936 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882094007937 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 882094007938 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 882094007939 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 882094007940 Walker A/P-loop; other site 882094007941 ATP binding site [chemical binding]; other site 882094007942 Q-loop/lid; other site 882094007943 ABC transporter signature motif; other site 882094007944 Walker B; other site 882094007945 D-loop; other site 882094007946 H-loop/switch region; other site 882094007947 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 882094007948 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 882094007949 ABC-ATPase subunit interface; other site 882094007950 dimer interface [polypeptide binding]; other site 882094007951 putative PBP binding regions; other site 882094007952 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 882094007953 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 882094007954 intersubunit interface [polypeptide binding]; other site 882094007955 Predicted esterase [General function prediction only]; Region: COG0627 882094007956 S-formylglutathione hydrolase; Region: PLN02442 882094007957 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 882094007958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094007959 catalytic residue [active] 882094007960 SdpI/YhfL protein family; Region: SdpI; pfam13630 882094007961 CAT RNA binding domain; Region: CAT_RBD; smart01061 882094007962 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882094007963 PRD domain; Region: PRD; pfam00874 882094007964 PRD domain; Region: PRD; pfam00874 882094007965 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 882094007966 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 882094007967 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 882094007968 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 882094007969 Predicted transcriptional regulator [Transcription]; Region: COG2378 882094007970 HTH domain; Region: HTH_11; pfam08279 882094007971 WYL domain; Region: WYL; pfam13280 882094007972 Uncharacterized conserved protein [Function unknown]; Region: COG1434 882094007973 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 882094007974 putative active site [active] 882094007975 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094007976 Leucine rich repeat; Region: LRR_8; pfam13855 882094007977 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882094007978 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 882094007979 active site 882094007980 catalytic site [active] 882094007981 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882094007982 putative metal binding site [ion binding]; other site 882094007983 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882094007984 putative metal binding site [ion binding]; other site 882094007985 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094007986 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 882094007987 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 882094007988 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 882094007989 active site 882094007990 catalytic site [active] 882094007991 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 882094007992 putative metal binding site [ion binding]; other site 882094007993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094007994 non-specific DNA binding site [nucleotide binding]; other site 882094007995 salt bridge; other site 882094007996 sequence-specific DNA binding site [nucleotide binding]; other site 882094007997 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 882094007998 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 882094007999 SmpB-tmRNA interface; other site 882094008000 ribonuclease R; Region: RNase_R; TIGR02063 882094008001 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 882094008002 RNB domain; Region: RNB; pfam00773 882094008003 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 882094008004 RNA binding site [nucleotide binding]; other site 882094008005 Esterase/lipase [General function prediction only]; Region: COG1647 882094008006 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094008007 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 882094008008 Preprotein translocase SecG subunit; Region: SecG; cl09123 882094008009 Esterase/lipase [General function prediction only]; Region: COG1647 882094008010 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 882094008011 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 882094008012 PGAP1-like protein; Region: PGAP1; pfam07819 882094008013 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 882094008014 enolase; Provisional; Region: eno; PRK00077 882094008015 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 882094008016 dimer interface [polypeptide binding]; other site 882094008017 metal binding site [ion binding]; metal-binding site 882094008018 substrate binding pocket [chemical binding]; other site 882094008019 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 882094008020 phosphoglyceromutase; Provisional; Region: PRK05434 882094008021 triosephosphate isomerase; Provisional; Region: PRK14567 882094008022 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 882094008023 substrate binding site [chemical binding]; other site 882094008024 dimer interface [polypeptide binding]; other site 882094008025 catalytic triad [active] 882094008026 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 882094008027 Phosphoglycerate kinase; Region: PGK; pfam00162 882094008028 substrate binding site [chemical binding]; other site 882094008029 hinge regions; other site 882094008030 ADP binding site [chemical binding]; other site 882094008031 catalytic site [active] 882094008032 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 882094008033 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 882094008034 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 882094008035 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 882094008036 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 882094008037 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 882094008038 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 882094008039 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 882094008040 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094008041 DNA binding site [nucleotide binding] 882094008042 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 882094008043 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 882094008044 active site 882094008045 dimer interface [polypeptide binding]; other site 882094008046 MMPL family; Region: MMPL; pfam03176 882094008047 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 882094008048 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094008049 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094008050 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 882094008051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 882094008052 Chitin binding domain; Region: Chitin_bind_3; pfam03067 882094008053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882094008054 Interdomain contacts; other site 882094008055 Cytokine receptor motif; other site 882094008056 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 882094008057 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 882094008058 Interdomain contacts; other site 882094008059 Cytokine receptor motif; other site 882094008060 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882094008061 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882094008062 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 882094008063 aromatic chitin/cellulose binding site residues [chemical binding]; other site 882094008064 Clp protease; Region: CLP_protease; pfam00574 882094008065 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 882094008066 oligomer interface [polypeptide binding]; other site 882094008067 active site residues [active] 882094008068 amino acid transporter; Region: 2A0306; TIGR00909 882094008069 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 882094008070 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 882094008071 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094008072 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094008073 Substrate binding site [chemical binding]; other site 882094008074 Leucine rich repeat; Region: LRR_8; pfam13855 882094008075 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094008076 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 882094008077 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 882094008078 active site 882094008079 FMN binding site [chemical binding]; other site 882094008080 substrate binding site [chemical binding]; other site 882094008081 homotetramer interface [polypeptide binding]; other site 882094008082 catalytic residue [active] 882094008083 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 882094008084 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 882094008085 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 882094008086 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 882094008087 phosphate binding site [ion binding]; other site 882094008088 putative substrate binding pocket [chemical binding]; other site 882094008089 dimer interface [polypeptide binding]; other site 882094008090 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 882094008091 AAA domain; Region: AAA_18; pfam13238 882094008092 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 882094008093 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 882094008094 active site 882094008095 substrate binding site [chemical binding]; other site 882094008096 metal binding site [ion binding]; metal-binding site 882094008097 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 882094008098 active site 882094008099 catalytic residues [active] 882094008100 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 882094008101 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 882094008102 NAD binding site [chemical binding]; other site 882094008103 homodimer interface [polypeptide binding]; other site 882094008104 active site 882094008105 substrate binding site [chemical binding]; other site 882094008106 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 882094008107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 882094008108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094008109 TPR repeat; Region: TPR_11; pfam13414 882094008110 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094008111 binding surface 882094008112 TPR motif; other site 882094008113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 882094008114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 882094008115 binding surface 882094008116 TPR motif; other site 882094008117 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 882094008118 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 882094008119 putative trimer interface [polypeptide binding]; other site 882094008120 putative CoA binding site [chemical binding]; other site 882094008121 pyrophosphatase PpaX; Provisional; Region: PRK13288 882094008122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094008123 motif II; other site 882094008124 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 882094008125 HPr kinase/phosphorylase; Provisional; Region: PRK05428 882094008126 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 882094008127 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 882094008128 Hpr binding site; other site 882094008129 active site 882094008130 homohexamer subunit interaction site [polypeptide binding]; other site 882094008131 Predicted membrane protein [Function unknown]; Region: COG1950 882094008132 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 882094008133 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 882094008134 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882094008135 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882094008136 Uncharacterized conserved protein [Function unknown]; Region: COG3595 882094008137 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 882094008138 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 882094008139 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882094008140 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 882094008141 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 882094008142 excinuclease ABC subunit B; Provisional; Region: PRK05298 882094008143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094008144 ATP binding site [chemical binding]; other site 882094008145 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094008146 nucleotide binding region [chemical binding]; other site 882094008147 ATP-binding site [chemical binding]; other site 882094008148 Ultra-violet resistance protein B; Region: UvrB; pfam12344 882094008149 UvrB/uvrC motif; Region: UVR; pfam02151 882094008150 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 882094008151 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 882094008152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 882094008153 dimerization interface [polypeptide binding]; other site 882094008154 putative DNA binding site [nucleotide binding]; other site 882094008155 putative Zn2+ binding site [ion binding]; other site 882094008156 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 882094008157 PhoU domain; Region: PhoU; pfam01895 882094008158 PhoU domain; Region: PhoU; pfam01895 882094008159 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882094008160 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882094008161 Walker A/P-loop; other site 882094008162 ATP binding site [chemical binding]; other site 882094008163 Q-loop/lid; other site 882094008164 ABC transporter signature motif; other site 882094008165 Walker B; other site 882094008166 D-loop; other site 882094008167 H-loop/switch region; other site 882094008168 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 882094008169 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 882094008170 Walker A/P-loop; other site 882094008171 ATP binding site [chemical binding]; other site 882094008172 Q-loop/lid; other site 882094008173 ABC transporter signature motif; other site 882094008174 Walker B; other site 882094008175 D-loop; other site 882094008176 H-loop/switch region; other site 882094008177 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 882094008178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094008179 dimer interface [polypeptide binding]; other site 882094008180 conserved gate region; other site 882094008181 putative PBP binding loops; other site 882094008182 ABC-ATPase subunit interface; other site 882094008183 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 882094008184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094008185 dimer interface [polypeptide binding]; other site 882094008186 conserved gate region; other site 882094008187 putative PBP binding loops; other site 882094008188 ABC-ATPase subunit interface; other site 882094008189 PBP superfamily domain; Region: PBP_like_2; cl17296 882094008190 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 882094008191 HAMP domain; Region: HAMP; pfam00672 882094008192 dimerization interface [polypeptide binding]; other site 882094008193 PAS domain; Region: PAS; smart00091 882094008194 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 882094008195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094008196 dimer interface [polypeptide binding]; other site 882094008197 phosphorylation site [posttranslational modification] 882094008198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094008199 ATP binding site [chemical binding]; other site 882094008200 Mg2+ binding site [ion binding]; other site 882094008201 G-X-G motif; other site 882094008202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094008203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094008204 active site 882094008205 phosphorylation site [posttranslational modification] 882094008206 intermolecular recognition site; other site 882094008207 dimerization interface [polypeptide binding]; other site 882094008208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094008209 DNA binding site [nucleotide binding] 882094008210 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 882094008211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 882094008212 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 882094008213 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 882094008214 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 882094008215 putative active site [active] 882094008216 catalytic site [active] 882094008217 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 882094008218 putative active site [active] 882094008219 catalytic site [active] 882094008220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882094008221 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 882094008222 Peptidase family M23; Region: Peptidase_M23; pfam01551 882094008223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 882094008224 NlpC/P60 family; Region: NLPC_P60; pfam00877 882094008225 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 882094008226 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 882094008227 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 882094008228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094008229 Walker A/P-loop; other site 882094008230 ATP binding site [chemical binding]; other site 882094008231 Q-loop/lid; other site 882094008232 ABC transporter signature motif; other site 882094008233 Walker B; other site 882094008234 D-loop; other site 882094008235 H-loop/switch region; other site 882094008236 Uncharacterized conserved protein [Function unknown]; Region: COG1284 882094008237 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094008238 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 882094008239 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 882094008240 peptide chain release factor 2; Validated; Region: prfB; PRK00578 882094008241 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882094008242 RF-1 domain; Region: RF-1; pfam00472 882094008243 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 882094008244 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 882094008245 nucleotide binding region [chemical binding]; other site 882094008246 helicase superfamily c-terminal domain; Region: HELICc; smart00490 882094008247 ATP-binding site [chemical binding]; other site 882094008248 SEC-C motif; Region: SEC-C; pfam02810 882094008249 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 882094008250 30S subunit binding site; other site 882094008251 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 882094008252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094008253 active site 882094008254 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 882094008255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094008256 ATP binding site [chemical binding]; other site 882094008257 putative Mg++ binding site [ion binding]; other site 882094008258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094008259 nucleotide binding region [chemical binding]; other site 882094008260 ATP-binding site [chemical binding]; other site 882094008261 EDD domain protein, DegV family; Region: DegV; TIGR00762 882094008262 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 882094008263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 882094008264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094008265 active site 882094008266 phosphorylation site [posttranslational modification] 882094008267 intermolecular recognition site; other site 882094008268 dimerization interface [polypeptide binding]; other site 882094008269 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 882094008270 DNA binding residues [nucleotide binding] 882094008271 dimerization interface [polypeptide binding]; other site 882094008272 Uncharacterized conserved protein [Function unknown]; Region: COG1739 882094008273 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 882094008274 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 882094008275 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 882094008276 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 882094008277 Transcriptional regulator [Transcription]; Region: LytR; COG1316 882094008278 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 882094008279 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 882094008280 Mg++ binding site [ion binding]; other site 882094008281 putative catalytic motif [active] 882094008282 substrate binding site [chemical binding]; other site 882094008283 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 882094008284 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 882094008285 active site 882094008286 octamer interface [polypeptide binding]; other site 882094008287 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 882094008288 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 882094008289 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008290 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008291 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 882094008292 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 882094008293 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 882094008294 dimer interface [polypeptide binding]; other site 882094008295 ssDNA binding site [nucleotide binding]; other site 882094008296 tetramer (dimer of dimers) interface [polypeptide binding]; other site 882094008297 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 882094008298 rod shape-determining protein Mbl; Provisional; Region: PRK13928 882094008299 MreB and similar proteins; Region: MreB_like; cd10225 882094008300 nucleotide binding site [chemical binding]; other site 882094008301 Mg binding site [ion binding]; other site 882094008302 putative protofilament interaction site [polypeptide binding]; other site 882094008303 RodZ interaction site [polypeptide binding]; other site 882094008304 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882094008305 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882094008306 hinge; other site 882094008307 active site 882094008308 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 882094008309 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 882094008310 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 882094008311 gamma subunit interface [polypeptide binding]; other site 882094008312 epsilon subunit interface [polypeptide binding]; other site 882094008313 LBP interface [polypeptide binding]; other site 882094008314 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 882094008315 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882094008316 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 882094008317 alpha subunit interaction interface [polypeptide binding]; other site 882094008318 Walker A motif; other site 882094008319 ATP binding site [chemical binding]; other site 882094008320 Walker B motif; other site 882094008321 inhibitor binding site; inhibition site 882094008322 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882094008323 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 882094008324 core domain interface [polypeptide binding]; other site 882094008325 delta subunit interface [polypeptide binding]; other site 882094008326 epsilon subunit interface [polypeptide binding]; other site 882094008327 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 882094008328 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 882094008329 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 882094008330 beta subunit interaction interface [polypeptide binding]; other site 882094008331 Walker A motif; other site 882094008332 ATP binding site [chemical binding]; other site 882094008333 Walker B motif; other site 882094008334 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 882094008335 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 882094008336 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 882094008337 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 882094008338 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 882094008339 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 882094008340 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 882094008341 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 882094008342 ATP synthase I chain; Region: ATP_synt_I; pfam03899 882094008343 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 882094008344 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 882094008345 active site 882094008346 homodimer interface [polypeptide binding]; other site 882094008347 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 882094008348 active site 882094008349 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 882094008350 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 882094008351 dimer interface [polypeptide binding]; other site 882094008352 active site 882094008353 glycine-pyridoxal phosphate binding site [chemical binding]; other site 882094008354 folate binding site [chemical binding]; other site 882094008355 Low molecular weight phosphatase family; Region: LMWPc; cd00115 882094008356 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 882094008357 active site 882094008358 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 882094008359 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 882094008360 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 882094008361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094008362 S-adenosylmethionine binding site [chemical binding]; other site 882094008363 peptide chain release factor 1; Validated; Region: prfA; PRK00591 882094008364 This domain is found in peptide chain release factors; Region: PCRF; smart00937 882094008365 RF-1 domain; Region: RF-1; pfam00472 882094008366 thymidine kinase; Provisional; Region: PRK04296 882094008367 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 882094008368 ATP binding site [chemical binding]; other site 882094008369 Walker A motif; other site 882094008370 Walker B motif; other site 882094008371 homoserine kinase; Provisional; Region: PRK01212 882094008372 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 882094008373 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 882094008374 threonine synthase; Reviewed; Region: PRK06721 882094008375 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 882094008376 homodimer interface [polypeptide binding]; other site 882094008377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094008378 catalytic residue [active] 882094008379 homoserine dehydrogenase; Provisional; Region: PRK06349 882094008380 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 882094008381 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 882094008382 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 882094008383 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 882094008384 Predicted membrane protein [Function unknown]; Region: COG2246 882094008385 GtrA-like protein; Region: GtrA; pfam04138 882094008386 transcription termination factor Rho; Provisional; Region: rho; PRK09376 882094008387 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 882094008388 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 882094008389 RNA binding site [nucleotide binding]; other site 882094008390 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 882094008391 multimer interface [polypeptide binding]; other site 882094008392 Walker A motif; other site 882094008393 ATP binding site [chemical binding]; other site 882094008394 Walker B motif; other site 882094008395 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 882094008396 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 882094008397 hinge; other site 882094008398 active site 882094008399 Predicted integral membrane protein [Function unknown]; Region: COG0392 882094008400 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882094008401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 882094008402 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 882094008403 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 882094008404 putative ADP-binding pocket [chemical binding]; other site 882094008405 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 882094008406 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 882094008407 intersubunit interface [polypeptide binding]; other site 882094008408 active site 882094008409 zinc binding site [ion binding]; other site 882094008410 Na+ binding site [ion binding]; other site 882094008411 putative lipid kinase; Reviewed; Region: PRK13055 882094008412 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 882094008413 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 882094008414 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 882094008415 substrate binding site [chemical binding]; other site 882094008416 SH3-like domain; Region: SH3_8; pfam13457 882094008417 SH3-like domain; Region: SH3_8; pfam13457 882094008418 CTP synthetase; Validated; Region: pyrG; PRK05380 882094008419 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 882094008420 Catalytic site [active] 882094008421 active site 882094008422 UTP binding site [chemical binding]; other site 882094008423 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 882094008424 active site 882094008425 putative oxyanion hole; other site 882094008426 catalytic triad [active] 882094008427 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 882094008428 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 882094008429 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 882094008430 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 882094008431 active site 882094008432 HIGH motif; other site 882094008433 KMSK motif region; other site 882094008434 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 882094008435 tRNA binding surface [nucleotide binding]; other site 882094008436 anticodon binding site; other site 882094008437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 882094008438 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 882094008439 Peptidase family M50; Region: Peptidase_M50; pfam02163 882094008440 active site 882094008441 putative substrate binding region [chemical binding]; other site 882094008442 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 882094008443 active site 1 [active] 882094008444 dimer interface [polypeptide binding]; other site 882094008445 hexamer interface [polypeptide binding]; other site 882094008446 active site 2 [active] 882094008447 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 882094008448 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094008449 Zn2+ binding site [ion binding]; other site 882094008450 Mg2+ binding site [ion binding]; other site 882094008451 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 882094008452 conserved hypothetical protein TIGR01655; Region: yxeA_fam 882094008453 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 882094008454 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 882094008455 peptide binding site [polypeptide binding]; other site 882094008456 Predicted integral membrane protein [Function unknown]; Region: COG5658 882094008457 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 882094008458 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 882094008459 catalytic triad [active] 882094008460 metal binding site [ion binding]; metal-binding site 882094008461 conserved cis-peptide bond; other site 882094008462 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 882094008463 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 882094008464 folate binding site [chemical binding]; other site 882094008465 NADP+ binding site [chemical binding]; other site 882094008466 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 882094008467 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 882094008468 putative NAD(P) binding site [chemical binding]; other site 882094008469 dimer interface [polypeptide binding]; other site 882094008470 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 882094008471 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 882094008472 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094008473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094008474 active site 882094008475 motif I; other site 882094008476 motif II; other site 882094008477 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 882094008478 Uncharacterized conserved protein [Function unknown]; Region: COG1359 882094008479 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 882094008480 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094008481 Walker A/P-loop; other site 882094008482 ATP binding site [chemical binding]; other site 882094008483 Q-loop/lid; other site 882094008484 ABC transporter signature motif; other site 882094008485 Walker B; other site 882094008486 D-loop; other site 882094008487 H-loop/switch region; other site 882094008488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 882094008489 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 882094008490 FtsX-like permease family; Region: FtsX; pfam02687 882094008491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 882094008492 dimerization interface [polypeptide binding]; other site 882094008493 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094008494 dimer interface [polypeptide binding]; other site 882094008495 phosphorylation site [posttranslational modification] 882094008496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094008497 ATP binding site [chemical binding]; other site 882094008498 Mg2+ binding site [ion binding]; other site 882094008499 G-X-G motif; other site 882094008500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094008501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094008502 active site 882094008503 phosphorylation site [posttranslational modification] 882094008504 intermolecular recognition site; other site 882094008505 dimerization interface [polypeptide binding]; other site 882094008506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094008507 DNA binding site [nucleotide binding] 882094008508 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 882094008509 Uncharacterized conserved protein [Function unknown]; Region: COG2427 882094008510 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 882094008511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 882094008512 catalytic loop [active] 882094008513 iron binding site [ion binding]; other site 882094008514 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 882094008515 4Fe-4S binding domain; Region: Fer4; pfam00037 882094008516 4Fe-4S binding domain; Region: Fer4; pfam00037 882094008517 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 882094008518 [4Fe-4S] binding site [ion binding]; other site 882094008519 molybdopterin cofactor binding site; other site 882094008520 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 882094008521 molybdopterin cofactor binding site; other site 882094008522 Uncharacterized conserved protein [Function unknown]; Region: COG1912 882094008523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094008524 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094008525 putative substrate translocation pore; other site 882094008526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094008527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094008528 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 882094008529 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 882094008530 Walker A motif; other site 882094008531 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094008532 SH3-like domain; Region: SH3_8; pfam13457 882094008533 SH3-like domain; Region: SH3_8; pfam13457 882094008534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094008535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094008536 active site 882094008537 catalytic tetrad [active] 882094008538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094008539 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094008540 DNA binding residues [nucleotide binding] 882094008541 putative dimer interface [polypeptide binding]; other site 882094008542 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 882094008543 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 882094008544 23S rRNA interface [nucleotide binding]; other site 882094008545 L3 interface [polypeptide binding]; other site 882094008546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 882094008547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 882094008548 dimerization interface 3.5A [polypeptide binding]; other site 882094008549 active site 882094008550 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882094008551 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 882094008552 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882094008553 Walker A/P-loop; other site 882094008554 ATP binding site [chemical binding]; other site 882094008555 Q-loop/lid; other site 882094008556 ABC transporter signature motif; other site 882094008557 Walker B; other site 882094008558 D-loop; other site 882094008559 H-loop/switch region; other site 882094008560 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 882094008561 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 882094008562 Walker A/P-loop; other site 882094008563 ATP binding site [chemical binding]; other site 882094008564 Q-loop/lid; other site 882094008565 ABC transporter signature motif; other site 882094008566 Walker B; other site 882094008567 D-loop; other site 882094008568 H-loop/switch region; other site 882094008569 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 882094008570 MgtC family; Region: MgtC; pfam02308 882094008571 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 882094008572 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 882094008573 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 882094008574 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 882094008575 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 882094008576 alphaNTD - beta interaction site [polypeptide binding]; other site 882094008577 alphaNTD homodimer interface [polypeptide binding]; other site 882094008578 alphaNTD - beta' interaction site [polypeptide binding]; other site 882094008579 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 882094008580 30S ribosomal protein S11; Validated; Region: PRK05309 882094008581 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 882094008582 30S ribosomal protein S13; Region: bact_S13; TIGR03631 882094008583 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 882094008584 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 882094008585 rRNA binding site [nucleotide binding]; other site 882094008586 predicted 30S ribosome binding site; other site 882094008587 adenylate kinase; Reviewed; Region: adk; PRK00279 882094008588 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 882094008589 AMP-binding site [chemical binding]; other site 882094008590 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 882094008591 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 882094008592 SecY translocase; Region: SecY; pfam00344 882094008593 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 882094008594 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 882094008595 23S rRNA binding site [nucleotide binding]; other site 882094008596 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 882094008597 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 882094008598 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 882094008599 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 882094008600 5S rRNA interface [nucleotide binding]; other site 882094008601 L27 interface [polypeptide binding]; other site 882094008602 23S rRNA interface [nucleotide binding]; other site 882094008603 L5 interface [polypeptide binding]; other site 882094008604 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 882094008605 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882094008606 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 882094008607 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 882094008608 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 882094008609 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 882094008610 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 882094008611 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 882094008612 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 882094008613 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 882094008614 RNA binding site [nucleotide binding]; other site 882094008615 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 882094008616 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 882094008617 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 882094008618 23S rRNA interface [nucleotide binding]; other site 882094008619 putative translocon interaction site; other site 882094008620 signal recognition particle (SRP54) interaction site; other site 882094008621 L23 interface [polypeptide binding]; other site 882094008622 trigger factor interaction site; other site 882094008623 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 882094008624 23S rRNA interface [nucleotide binding]; other site 882094008625 5S rRNA interface [nucleotide binding]; other site 882094008626 putative antibiotic binding site [chemical binding]; other site 882094008627 L25 interface [polypeptide binding]; other site 882094008628 L27 interface [polypeptide binding]; other site 882094008629 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 882094008630 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 882094008631 G-X-X-G motif; other site 882094008632 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 882094008633 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 882094008634 putative translocon binding site; other site 882094008635 protein-rRNA interface [nucleotide binding]; other site 882094008636 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 882094008637 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 882094008638 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 882094008639 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 882094008640 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 882094008641 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 882094008642 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 882094008643 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 882094008644 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 882094008645 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 882094008646 UbiA prenyltransferase family; Region: UbiA; pfam01040 882094008647 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 882094008648 ApbE family; Region: ApbE; pfam02424 882094008649 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 882094008650 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882094008651 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 882094008652 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 882094008653 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 882094008654 Predicted membrane protein [Function unknown]; Region: COG2259 882094008655 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 882094008656 trimer interface [polypeptide binding]; other site 882094008657 Predicted membrane protein [Function unknown]; Region: COG4769 882094008658 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 882094008659 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 882094008660 substrate binding pocket [chemical binding]; other site 882094008661 chain length determination region; other site 882094008662 substrate-Mg2+ binding site; other site 882094008663 catalytic residues [active] 882094008664 aspartate-rich region 1; other site 882094008665 active site lid residues [active] 882094008666 aspartate-rich region 2; other site 882094008667 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 882094008668 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 882094008669 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 882094008670 active site 882094008671 metal binding site [ion binding]; metal-binding site 882094008672 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 882094008673 hypothetical protein; Provisional; Region: PRK02947 882094008674 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094008675 putative active site [active] 882094008676 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 882094008677 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 882094008678 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 882094008679 active site 882094008680 substrate binding pocket [chemical binding]; other site 882094008681 homodimer interaction site [polypeptide binding]; other site 882094008682 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 882094008683 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 882094008684 active site 882094008685 P-loop; other site 882094008686 phosphorylation site [posttranslational modification] 882094008687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094008688 active site 882094008689 phosphorylation site [posttranslational modification] 882094008690 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094008691 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094008692 PRD domain; Region: PRD; pfam00874 882094008693 PRD domain; Region: PRD; pfam00874 882094008694 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094008695 active site 882094008696 P-loop; other site 882094008697 phosphorylation site [posttranslational modification] 882094008698 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094008699 active site 882094008700 phosphorylation site [posttranslational modification] 882094008701 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 882094008702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094008703 Walker A/P-loop; other site 882094008704 ATP binding site [chemical binding]; other site 882094008705 Q-loop/lid; other site 882094008706 ABC transporter signature motif; other site 882094008707 Walker B; other site 882094008708 D-loop; other site 882094008709 H-loop/switch region; other site 882094008710 elongation factor Tu; Reviewed; Region: PRK00049 882094008711 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 882094008712 G1 box; other site 882094008713 GEF interaction site [polypeptide binding]; other site 882094008714 GTP/Mg2+ binding site [chemical binding]; other site 882094008715 Switch I region; other site 882094008716 G2 box; other site 882094008717 G3 box; other site 882094008718 Switch II region; other site 882094008719 G4 box; other site 882094008720 G5 box; other site 882094008721 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 882094008722 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 882094008723 Antibiotic Binding Site [chemical binding]; other site 882094008724 elongation factor G; Reviewed; Region: PRK00007 882094008725 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 882094008726 G1 box; other site 882094008727 putative GEF interaction site [polypeptide binding]; other site 882094008728 GTP/Mg2+ binding site [chemical binding]; other site 882094008729 Switch I region; other site 882094008730 G2 box; other site 882094008731 G3 box; other site 882094008732 Switch II region; other site 882094008733 G4 box; other site 882094008734 G5 box; other site 882094008735 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 882094008736 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 882094008737 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 882094008738 30S ribosomal protein S7; Validated; Region: PRK05302 882094008739 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 882094008740 S17 interaction site [polypeptide binding]; other site 882094008741 S8 interaction site; other site 882094008742 16S rRNA interaction site [nucleotide binding]; other site 882094008743 streptomycin interaction site [chemical binding]; other site 882094008744 23S rRNA interaction site [nucleotide binding]; other site 882094008745 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 882094008746 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 882094008747 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 882094008748 Zn2+ binding site [ion binding]; other site 882094008749 Mg2+ binding site [ion binding]; other site 882094008750 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 882094008751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094008752 Coenzyme A binding pocket [chemical binding]; other site 882094008753 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 882094008754 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094008755 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094008756 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882094008757 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882094008758 substrate binding site [chemical binding]; other site 882094008759 hexamer interface [polypeptide binding]; other site 882094008760 metal binding site [ion binding]; metal-binding site 882094008761 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 882094008762 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 882094008763 TPP-binding site [chemical binding]; other site 882094008764 dimer interface [polypeptide binding]; other site 882094008765 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 882094008766 PYR/PP interface [polypeptide binding]; other site 882094008767 dimer interface [polypeptide binding]; other site 882094008768 TPP binding site [chemical binding]; other site 882094008769 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 882094008770 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 882094008771 substrate binding site [chemical binding]; other site 882094008772 hexamer interface [polypeptide binding]; other site 882094008773 metal binding site [ion binding]; metal-binding site 882094008774 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 882094008775 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882094008776 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 882094008777 putative NAD(P) binding site [chemical binding]; other site 882094008778 catalytic Zn binding site [ion binding]; other site 882094008779 structural Zn binding site [ion binding]; other site 882094008780 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882094008781 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 882094008782 putative NAD(P) binding site [chemical binding]; other site 882094008783 catalytic Zn binding site [ion binding]; other site 882094008784 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 882094008785 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 882094008786 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 882094008787 active site 882094008788 P-loop; other site 882094008789 phosphorylation site [posttranslational modification] 882094008790 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094008791 active site 882094008792 phosphorylation site [posttranslational modification] 882094008793 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094008794 PRD domain; Region: PRD; pfam00874 882094008795 PRD domain; Region: PRD; pfam00874 882094008796 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094008797 active site 882094008798 P-loop; other site 882094008799 phosphorylation site [posttranslational modification] 882094008800 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 882094008801 active site 882094008802 phosphorylation site [posttranslational modification] 882094008803 Predicted membrane protein [Function unknown]; Region: COG4905 882094008804 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 882094008805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 882094008806 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 882094008807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 882094008808 active site 882094008809 Helix-turn-helix domain; Region: HTH_18; pfam12833 882094008810 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 882094008811 Ligand Binding Site [chemical binding]; other site 882094008812 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 882094008813 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 882094008814 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 882094008815 active site 882094008816 DNA binding site [nucleotide binding] 882094008817 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 882094008818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 882094008819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 882094008820 active site 882094008821 phosphorylation site [posttranslational modification] 882094008822 intermolecular recognition site; other site 882094008823 dimerization interface [polypeptide binding]; other site 882094008824 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 882094008825 DNA binding site [nucleotide binding] 882094008826 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 882094008827 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 882094008828 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 882094008829 Ligand Binding Site [chemical binding]; other site 882094008830 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 882094008831 GAF domain; Region: GAF_3; pfam13492 882094008832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 882094008833 dimer interface [polypeptide binding]; other site 882094008834 phosphorylation site [posttranslational modification] 882094008835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 882094008836 ATP binding site [chemical binding]; other site 882094008837 Mg2+ binding site [ion binding]; other site 882094008838 G-X-G motif; other site 882094008839 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 882094008840 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 882094008841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094008842 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 882094008843 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094008844 active site 882094008845 P-loop; other site 882094008846 phosphorylation site [posttranslational modification] 882094008847 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094008848 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094008849 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094008850 methionine cluster; other site 882094008851 active site 882094008852 phosphorylation site [posttranslational modification] 882094008853 metal binding site [ion binding]; metal-binding site 882094008854 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882094008855 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 882094008856 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 882094008857 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 882094008858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 882094008859 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 882094008860 Soluble P-type ATPase [General function prediction only]; Region: COG4087 882094008861 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 882094008862 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094008863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094008864 autolysin; Reviewed; Region: PRK06347 882094008865 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 882094008866 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008867 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 882094008870 Protein of unknown function (DUF970); Region: DUF970; pfam06153 882094008871 thymidylate kinase; Validated; Region: tmk; PRK00698 882094008872 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 882094008873 TMP-binding site; other site 882094008874 ATP-binding site [chemical binding]; other site 882094008875 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 882094008876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 882094008877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094008878 catalytic residue [active] 882094008879 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 882094008880 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 882094008881 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882094008882 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 882094008883 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 882094008884 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 882094008885 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094008886 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094008887 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094008888 putative active site [active] 882094008889 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 882094008890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094008891 active site 882094008892 motif I; other site 882094008893 motif II; other site 882094008894 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 882094008895 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 882094008896 nudix motif; other site 882094008897 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 882094008898 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 882094008899 active site 882094008900 catalytic tetrad [active] 882094008901 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 882094008902 recombination protein RecR; Reviewed; Region: recR; PRK00076 882094008903 RecR protein; Region: RecR; pfam02132 882094008904 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 882094008905 putative active site [active] 882094008906 putative metal-binding site [ion binding]; other site 882094008907 tetramer interface [polypeptide binding]; other site 882094008908 hypothetical protein; Validated; Region: PRK00153 882094008909 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 882094008910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 882094008911 Walker A motif; other site 882094008912 ATP binding site [chemical binding]; other site 882094008913 Walker B motif; other site 882094008914 arginine finger; other site 882094008915 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 882094008916 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 882094008917 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 882094008918 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094008919 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094008920 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 882094008921 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 882094008922 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 882094008923 N- and C-terminal domain interface [polypeptide binding]; other site 882094008924 active site 882094008925 catalytic site [active] 882094008926 metal binding site [ion binding]; metal-binding site 882094008927 carbohydrate binding site [chemical binding]; other site 882094008928 ATP binding site [chemical binding]; other site 882094008929 SH3-like domain; Region: SH3_8; pfam13457 882094008930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 882094008931 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 882094008932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094008933 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 882094008934 Walker A/P-loop; other site 882094008935 ATP binding site [chemical binding]; other site 882094008936 Q-loop/lid; other site 882094008937 ABC transporter signature motif; other site 882094008938 Walker B; other site 882094008939 D-loop; other site 882094008940 H-loop/switch region; other site 882094008941 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 882094008942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094008943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094008944 Walker A/P-loop; other site 882094008945 ATP binding site [chemical binding]; other site 882094008946 Q-loop/lid; other site 882094008947 ABC transporter signature motif; other site 882094008948 Walker B; other site 882094008949 D-loop; other site 882094008950 H-loop/switch region; other site 882094008951 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 882094008952 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 882094008953 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 882094008954 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 882094008955 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 882094008956 nucleoside/Zn binding site; other site 882094008957 dimer interface [polypeptide binding]; other site 882094008958 catalytic motif [active] 882094008959 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 882094008960 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 882094008961 active site 882094008962 acyl-activating enzyme (AAE) consensus motif; other site 882094008963 putative CoA binding site [chemical binding]; other site 882094008964 AMP binding site [chemical binding]; other site 882094008965 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 882094008966 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 882094008967 active site 882094008968 trimer interface [polypeptide binding]; other site 882094008969 allosteric site; other site 882094008970 active site lid [active] 882094008971 hexamer (dimer of trimers) interface [polypeptide binding]; other site 882094008972 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 882094008973 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 882094008974 DNA binding residues [nucleotide binding] 882094008975 drug binding residues [chemical binding]; other site 882094008976 dimer interface [polypeptide binding]; other site 882094008977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 882094008978 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 882094008979 Coenzyme A binding pocket [chemical binding]; other site 882094008980 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 882094008981 dimer interface [polypeptide binding]; other site 882094008982 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 882094008983 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 882094008984 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 882094008985 MarR family; Region: MarR; pfam01047 882094008986 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 882094008987 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 882094008988 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 882094008989 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 882094008990 DNA binding residues [nucleotide binding] 882094008991 putative dimer interface [polypeptide binding]; other site 882094008992 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 882094008993 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 882094008994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094008995 active site 882094008996 motif I; other site 882094008997 motif II; other site 882094008998 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094008999 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094009000 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094009001 putative active site [active] 882094009002 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 882094009003 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094009004 active site 882094009005 phosphorylation site [posttranslational modification] 882094009006 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 882094009007 active site 882094009008 P-loop; other site 882094009009 phosphorylation site [posttranslational modification] 882094009010 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 882094009011 alpha-mannosidase; Provisional; Region: PRK09819 882094009012 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 882094009013 active site 882094009014 metal binding site [ion binding]; metal-binding site 882094009015 catalytic site [active] 882094009016 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 882094009017 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882094009018 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882094009019 active site 882094009020 homodimer interface [polypeptide binding]; other site 882094009021 catalytic site [active] 882094009022 glycerate kinase; Region: TIGR00045 882094009023 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094009024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094009025 DNA binding site [nucleotide binding] 882094009026 domain linker motif; other site 882094009027 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 882094009028 putative dimerization interface [polypeptide binding]; other site 882094009029 putative ligand binding site [chemical binding]; other site 882094009030 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 882094009031 Domain of unknown function DUF21; Region: DUF21; pfam01595 882094009032 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 882094009033 Transporter associated domain; Region: CorC_HlyC; pfam03471 882094009034 NAD-dependent deacetylase; Provisional; Region: PRK00481 882094009035 SIR2H: Uncharacterized prokaryotic Sir2 homologs from several gram positive bacterial species and Fusobacteria; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone...; Region: SIR2H; cd01411 882094009036 NAD+ binding site [chemical binding]; other site 882094009037 substrate binding site [chemical binding]; other site 882094009038 putative Zn binding site [ion binding]; other site 882094009039 Pathogenicity locus; Region: Cdd1; pfam11731 882094009040 drug efflux system protein MdtG; Provisional; Region: PRK09874 882094009041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009042 putative substrate translocation pore; other site 882094009043 Src Homology 3 domain superfamily; Region: SH3; cl17036 882094009044 Variant SH3 domain; Region: SH3_2; pfam07653 882094009045 peptide ligand binding site [polypeptide binding]; other site 882094009046 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 882094009047 active site 882094009048 intersubunit interactions; other site 882094009049 catalytic residue [active] 882094009050 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 882094009051 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 882094009052 ligand binding site [chemical binding]; other site 882094009053 flexible hinge region; other site 882094009054 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 882094009055 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094009056 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094009057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094009058 Walker A/P-loop; other site 882094009059 ATP binding site [chemical binding]; other site 882094009060 Q-loop/lid; other site 882094009061 ABC transporter signature motif; other site 882094009062 Walker B; other site 882094009063 D-loop; other site 882094009064 H-loop/switch region; other site 882094009065 TfoX C-terminal domain; Region: TfoX_C; pfam04994 882094009066 seryl-tRNA synthetase; Provisional; Region: PRK05431 882094009067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 882094009068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 882094009069 dimer interface [polypeptide binding]; other site 882094009070 active site 882094009071 motif 1; other site 882094009072 motif 2; other site 882094009073 motif 3; other site 882094009074 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 882094009075 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 882094009076 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 882094009077 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 882094009078 glutamine binding [chemical binding]; other site 882094009079 catalytic triad [active] 882094009080 aminodeoxychorismate synthase; Provisional; Region: PRK07508 882094009081 chorismate binding enzyme; Region: Chorismate_bind; cl10555 882094009082 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 882094009083 substrate-cofactor binding pocket; other site 882094009084 homodimer interface [polypeptide binding]; other site 882094009085 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 882094009086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 882094009087 catalytic residue [active] 882094009088 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094009089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094009090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094009091 Walker A/P-loop; other site 882094009092 ATP binding site [chemical binding]; other site 882094009093 Q-loop/lid; other site 882094009094 ABC transporter signature motif; other site 882094009095 Walker B; other site 882094009096 D-loop; other site 882094009097 H-loop/switch region; other site 882094009098 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 882094009099 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 882094009100 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 882094009101 Walker A/P-loop; other site 882094009102 ATP binding site [chemical binding]; other site 882094009103 Q-loop/lid; other site 882094009104 ABC transporter signature motif; other site 882094009105 Walker B; other site 882094009106 D-loop; other site 882094009107 H-loop/switch region; other site 882094009108 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 882094009109 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 882094009110 Ligand binding site; other site 882094009111 Putative Catalytic site; other site 882094009112 DXD motif; other site 882094009113 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 882094009114 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882094009115 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 882094009116 Predicted acyl esterases [General function prediction only]; Region: COG2936 882094009117 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 882094009118 DNA topoisomerase III; Provisional; Region: PRK07726 882094009119 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 882094009120 active site 882094009121 putative interdomain interaction site [polypeptide binding]; other site 882094009122 putative metal-binding site [ion binding]; other site 882094009123 putative nucleotide binding site [chemical binding]; other site 882094009124 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 882094009125 domain I; other site 882094009126 DNA binding groove [nucleotide binding] 882094009127 phosphate binding site [ion binding]; other site 882094009128 domain II; other site 882094009129 domain III; other site 882094009130 nucleotide binding site [chemical binding]; other site 882094009131 catalytic site [active] 882094009132 domain IV; other site 882094009133 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 882094009134 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 882094009135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 882094009136 ATP binding site [chemical binding]; other site 882094009137 putative Mg++ binding site [ion binding]; other site 882094009138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 882094009139 nucleotide binding region [chemical binding]; other site 882094009140 ATP-binding site [chemical binding]; other site 882094009141 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 882094009142 HRDC domain; Region: HRDC; pfam00570 882094009143 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 882094009144 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 882094009145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 882094009146 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 882094009147 active site 882094009148 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 882094009149 putative ADP-ribose binding site [chemical binding]; other site 882094009150 putative active site [active] 882094009151 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 882094009152 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094009153 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094009154 ABC transporter; Region: ABC_tran_2; pfam12848 882094009155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 882094009156 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 882094009157 beta-galactosidase; Region: BGL; TIGR03356 882094009158 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094009159 active site 882094009160 P-loop; other site 882094009161 phosphorylation site [posttranslational modification] 882094009162 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 882094009163 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094009164 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094009165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094009166 nucleotide binding site [chemical binding]; other site 882094009167 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094009168 methionine cluster; other site 882094009169 active site 882094009170 phosphorylation site [posttranslational modification] 882094009171 metal binding site [ion binding]; metal-binding site 882094009172 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094009173 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094009174 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094009175 putative active site [active] 882094009176 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 882094009177 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 882094009178 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 882094009179 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 882094009180 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 882094009181 Walker A/P-loop; other site 882094009182 ATP binding site [chemical binding]; other site 882094009183 Q-loop/lid; other site 882094009184 ABC transporter signature motif; other site 882094009185 Walker B; other site 882094009186 D-loop; other site 882094009187 H-loop/switch region; other site 882094009188 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 882094009189 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 882094009190 ATP-grasp domain; Region: ATP-grasp_4; cl17255 882094009191 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 882094009192 beta-galactosidase; Region: BGL; TIGR03356 882094009193 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 882094009194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 882094009195 active site turn [active] 882094009196 phosphorylation site [posttranslational modification] 882094009197 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 882094009198 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 882094009199 HPr interaction site; other site 882094009200 glycerol kinase (GK) interaction site [polypeptide binding]; other site 882094009201 active site 882094009202 phosphorylation site [posttranslational modification] 882094009203 transcriptional antiterminator BglG; Provisional; Region: PRK09772 882094009204 CAT RNA binding domain; Region: CAT_RBD; smart01061 882094009205 PRD domain; Region: PRD; pfam00874 882094009206 PRD domain; Region: PRD; pfam00874 882094009207 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 882094009208 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 882094009209 Walker A/P-loop; other site 882094009210 ATP binding site [chemical binding]; other site 882094009211 Q-loop/lid; other site 882094009212 ABC transporter signature motif; other site 882094009213 Walker B; other site 882094009214 D-loop; other site 882094009215 H-loop/switch region; other site 882094009216 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 882094009217 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 882094009218 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 882094009219 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 882094009220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009221 putative substrate translocation pore; other site 882094009222 GTP-binding protein YchF; Reviewed; Region: PRK09601 882094009223 YchF GTPase; Region: YchF; cd01900 882094009224 G1 box; other site 882094009225 GTP/Mg2+ binding site [chemical binding]; other site 882094009226 Switch I region; other site 882094009227 G2 box; other site 882094009228 Switch II region; other site 882094009229 G3 box; other site 882094009230 G4 box; other site 882094009231 G5 box; other site 882094009232 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 882094009233 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 882094009234 methionine cluster; other site 882094009235 active site 882094009236 phosphorylation site [posttranslational modification] 882094009237 metal binding site [ion binding]; metal-binding site 882094009238 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 882094009239 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 882094009240 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 882094009241 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 882094009242 active site 882094009243 P-loop; other site 882094009244 phosphorylation site [posttranslational modification] 882094009245 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 882094009246 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 882094009247 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 882094009248 HTH domain; Region: HTH_11; pfam08279 882094009249 Mga helix-turn-helix domain; Region: Mga; pfam05043 882094009250 PRD domain; Region: PRD; pfam00874 882094009251 PRD domain; Region: PRD; pfam00874 882094009252 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 882094009253 active site 882094009254 P-loop; other site 882094009255 phosphorylation site [posttranslational modification] 882094009256 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094009257 active site 882094009258 phosphorylation site [posttranslational modification] 882094009259 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 882094009260 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 882094009261 tetramer interface [polypeptide binding]; other site 882094009262 heme binding pocket [chemical binding]; other site 882094009263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 882094009264 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 882094009265 ParB-like nuclease domain; Region: ParB; smart00470 882094009266 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 882094009267 salt bridge; other site 882094009268 non-specific DNA binding site [nucleotide binding]; other site 882094009269 sequence-specific DNA binding site [nucleotide binding]; other site 882094009270 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 882094009271 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882094009272 P-loop; other site 882094009273 Magnesium ion binding site [ion binding]; other site 882094009274 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 882094009275 Magnesium ion binding site [ion binding]; other site 882094009276 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 882094009277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 882094009278 non-specific DNA binding site [nucleotide binding]; other site 882094009279 salt bridge; other site 882094009280 sequence-specific DNA binding site [nucleotide binding]; other site 882094009281 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 882094009282 ParB-like nuclease domain; Region: ParBc; pfam02195 882094009283 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 882094009284 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 882094009285 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 882094009286 putative active site [active] 882094009287 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 882094009288 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 882094009289 nucleotide binding site [chemical binding]; other site 882094009290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 882094009291 active site 882094009292 phosphorylation site [posttranslational modification] 882094009293 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 882094009294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094009295 motif II; other site 882094009296 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 882094009297 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 882094009298 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 882094009299 active site 882094009300 P-loop; other site 882094009301 phosphorylation site [posttranslational modification] 882094009302 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094009303 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094009304 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882094009305 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 882094009306 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 882094009307 putative active site cavity [active] 882094009308 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 882094009309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 882094009310 S-adenosylmethionine binding site [chemical binding]; other site 882094009311 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882094009312 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882094009313 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882094009314 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 882094009315 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 882094009316 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 882094009317 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 882094009318 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 882094009319 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 882094009320 trmE is a tRNA modification GTPase; Region: trmE; cd04164 882094009321 G1 box; other site 882094009322 GTP/Mg2+ binding site [chemical binding]; other site 882094009323 Switch I region; other site 882094009324 G2 box; other site 882094009325 Switch II region; other site 882094009326 G3 box; other site 882094009327 G4 box; other site 882094009328 G5 box; other site 882094009329 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 882094009330 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 882094009331 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 882094009332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 882094009333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 882094009334 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 882094009335 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 882094009336 NADP binding site [chemical binding]; other site 882094009337 homodimer interface [polypeptide binding]; other site 882094009338 active site 882094009339 substrate binding site [chemical binding]; other site 882094009340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009341 D-galactonate transporter; Region: 2A0114; TIGR00893 882094009342 putative substrate translocation pore; other site 882094009343 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882094009344 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882094009345 metal binding site [ion binding]; metal-binding site 882094009346 dimer interface [polypeptide binding]; other site 882094009347 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 882094009348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 882094009349 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 882094009350 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 882094009351 metal binding site [ion binding]; metal-binding site 882094009352 dimer interface [polypeptide binding]; other site 882094009353 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094009354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 882094009355 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 882094009356 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 882094009357 Leucine-rich repeats; other site 882094009358 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094009359 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 882094009360 Substrate binding site [chemical binding]; other site 882094009361 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094009362 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094009363 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094009364 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 882094009365 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 882094009366 Uncharacterized conserved protein [Function unknown]; Region: COG4198 882094009367 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 882094009368 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 882094009369 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 882094009370 putative ligand binding site [chemical binding]; other site 882094009371 putative NAD binding site [chemical binding]; other site 882094009372 putative catalytic site [active] 882094009373 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 882094009374 L-serine binding site [chemical binding]; other site 882094009375 ACT domain interface; other site 882094009376 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 882094009377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 882094009378 catalytic residue [active] 882094009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009380 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094009381 putative substrate translocation pore; other site 882094009382 Transcriptional regulators [Transcription]; Region: MarR; COG1846 882094009383 MarR family; Region: MarR_2; pfam12802 882094009384 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 882094009385 dimer interface [polypeptide binding]; other site 882094009386 FMN binding site [chemical binding]; other site 882094009387 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 882094009388 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 882094009389 catalytic residues [active] 882094009390 beta-phosphoglucomutase; Region: bPGM; TIGR01990 882094009391 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 882094009392 motif II; other site 882094009393 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 882094009394 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 882094009395 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 882094009396 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 882094009397 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 882094009398 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 882094009399 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 882094009400 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 882094009401 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 882094009402 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 882094009403 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 882094009404 putative NAD(P) binding site [chemical binding]; other site 882094009405 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 882094009406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094009407 dimer interface [polypeptide binding]; other site 882094009408 conserved gate region; other site 882094009409 putative PBP binding loops; other site 882094009410 ABC-ATPase subunit interface; other site 882094009411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 882094009412 dimer interface [polypeptide binding]; other site 882094009413 conserved gate region; other site 882094009414 putative PBP binding loops; other site 882094009415 ABC-ATPase subunit interface; other site 882094009416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 882094009417 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 882094009418 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 882094009419 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 882094009420 active site 882094009421 homodimer interface [polypeptide binding]; other site 882094009422 catalytic site [active] 882094009423 Transcriptional regulators [Transcription]; Region: PurR; COG1609 882094009424 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 882094009425 DNA binding site [nucleotide binding] 882094009426 domain linker motif; other site 882094009427 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 882094009428 putative dimerization interface [polypeptide binding]; other site 882094009429 putative ligand binding site [chemical binding]; other site 882094009430 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 882094009431 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 882094009432 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 882094009433 Coenzyme A binding pocket [chemical binding]; other site 882094009434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094009436 putative substrate translocation pore; other site 882094009437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009438 Domain of unknown function (DUF718); Region: DUF718; cl01281 882094009439 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 882094009440 intersubunit interface [polypeptide binding]; other site 882094009441 active site 882094009442 Zn2+ binding site [ion binding]; other site 882094009443 L-rhamnose isomerase; Provisional; Region: PRK01076 882094009444 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 882094009445 N- and C-terminal domain interface [polypeptide binding]; other site 882094009446 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 882094009447 active site 882094009448 putative catalytic site [active] 882094009449 metal binding site [ion binding]; metal-binding site 882094009450 ATP binding site [chemical binding]; other site 882094009451 carbohydrate binding site [chemical binding]; other site 882094009452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 882094009453 putative substrate translocation pore; other site 882094009454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 882094009455 Cupin domain; Region: Cupin_2; pfam07883 882094009456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 882094009457 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 882094009458 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 882094009459 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 882094009460 G-X-X-G motif; other site 882094009461 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 882094009462 RxxxH motif; other site 882094009463 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 882094009464 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 882094009465 ribonuclease P; Reviewed; Region: rnpA; PRK00499 882094009466 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399