-- dump date 20140619_133639 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1639000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1639000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1639000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639000004 Walker A motif; other site 1639000005 ATP binding site [chemical binding]; other site 1639000006 Walker B motif; other site 1639000007 arginine finger; other site 1639000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1639000009 DnaA box-binding interface [nucleotide binding]; other site 1639000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1639000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1639000012 putative DNA binding surface [nucleotide binding]; other site 1639000013 dimer interface [polypeptide binding]; other site 1639000014 beta-clamp/clamp loader binding surface; other site 1639000015 beta-clamp/translesion DNA polymerase binding surface; other site 1639000016 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639000017 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1639000018 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 1639000019 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1639000020 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1639000021 Walker A/P-loop; other site 1639000022 ATP binding site [chemical binding]; other site 1639000023 Q-loop/lid; other site 1639000024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639000025 ABC transporter signature motif; other site 1639000026 Walker B; other site 1639000027 D-loop; other site 1639000028 H-loop/switch region; other site 1639000029 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1639000030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639000031 Mg2+ binding site [ion binding]; other site 1639000032 G-X-G motif; other site 1639000033 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1639000034 anchoring element; other site 1639000035 dimer interface [polypeptide binding]; other site 1639000036 ATP binding site [chemical binding]; other site 1639000037 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1639000038 active site 1639000039 putative metal-binding site [ion binding]; other site 1639000040 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1639000041 DNA gyrase subunit A; Validated; Region: PRK05560 1639000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1639000043 CAP-like domain; other site 1639000044 active site 1639000045 primary dimer interface [polypeptide binding]; other site 1639000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639000051 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1639000052 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1639000053 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1639000054 catalytic site [active] 1639000055 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1639000056 putative active site [active] 1639000057 catalytic site [active] 1639000058 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1639000059 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639000060 Coenzyme A binding pocket [chemical binding]; other site 1639000061 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1639000062 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1639000063 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1639000064 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 1639000065 diphosphomevalonate decarboxylase; Region: PLN02407 1639000066 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 1639000067 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1639000068 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 1639000069 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1639000070 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1639000071 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1639000072 D-pathway; other site 1639000073 Putative ubiquinol binding site [chemical binding]; other site 1639000074 Low-spin heme (heme b) binding site [chemical binding]; other site 1639000075 Putative water exit pathway; other site 1639000076 Binuclear center (heme o3/CuB) [ion binding]; other site 1639000077 K-pathway; other site 1639000078 Putative proton exit pathway; other site 1639000079 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1639000080 Subunit I/III interface [polypeptide binding]; other site 1639000081 Subunit III/IV interface [polypeptide binding]; other site 1639000082 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1639000083 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1639000084 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1639000085 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1639000086 putative active site [active] 1639000087 putative metal binding site [ion binding]; other site 1639000088 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1639000089 beta-galactosidase; Region: BGL; TIGR03356 1639000090 Bacterial SH3 domain; Region: SH3_3; pfam08239 1639000091 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1639000092 putative active site [active] 1639000093 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639000094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639000095 DNA-binding site [nucleotide binding]; DNA binding site 1639000096 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639000097 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639000098 active site 1639000099 active pocket/dimerization site; other site 1639000100 phosphorylation site [posttranslational modification] 1639000101 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1639000102 active site 1639000103 phosphorylation site [posttranslational modification] 1639000104 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 1639000105 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1639000106 hypothetical protein; Provisional; Region: PRK02947 1639000107 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639000108 putative active site [active] 1639000109 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1639000110 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1639000111 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639000112 active site turn [active] 1639000113 phosphorylation site [posttranslational modification] 1639000114 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639000115 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1639000116 HPr interaction site; other site 1639000117 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639000118 active site 1639000119 phosphorylation site [posttranslational modification] 1639000120 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1639000121 putative dimer interface [polypeptide binding]; other site 1639000122 catalytic triad [active] 1639000123 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639000124 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639000125 DNA binding site [nucleotide binding] 1639000126 domain linker motif; other site 1639000127 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 1639000128 dimerization interface [polypeptide binding]; other site 1639000129 putative ligand binding site [chemical binding]; other site 1639000130 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639000131 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639000132 nucleotide binding site [chemical binding]; other site 1639000133 Butyrate kinase [Energy production and conversion]; Region: COG3426 1639000134 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1639000135 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1639000136 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639000137 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1639000138 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1639000139 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1639000140 dimer interface [polypeptide binding]; other site 1639000141 active site 1639000142 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1639000143 dimer interface [polypeptide binding]; other site 1639000144 active site 1639000145 putrescine carbamoyltransferase; Provisional; Region: PRK02255 1639000146 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1639000147 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1639000148 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1639000149 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 1639000150 agmatine deiminase; Provisional; Region: PRK13551 1639000151 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1639000152 carbamate kinase; Reviewed; Region: PRK12686 1639000153 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1639000154 putative substrate binding site [chemical binding]; other site 1639000155 nucleotide binding site [chemical binding]; other site 1639000156 nucleotide binding site [chemical binding]; other site 1639000157 homodimer interface [polypeptide binding]; other site 1639000158 agmatine deiminase; Provisional; Region: PRK13551 1639000159 agmatine deiminase; Region: agmatine_aguA; TIGR03380 1639000160 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639000161 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1639000162 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639000163 putative active site [active] 1639000164 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1639000165 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1639000166 arginine deiminase; Provisional; Region: PRK01388 1639000167 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1639000168 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1639000169 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1639000170 dimer interface [polypeptide binding]; other site 1639000171 ssDNA binding site [nucleotide binding]; other site 1639000172 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639000173 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1639000174 Predicted membrane protein [Function unknown]; Region: COG3212 1639000175 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1639000176 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1639000177 putative accessory gene regulator protein; Provisional; Region: PRK01100 1639000178 Staphylococcal AgrD protein; Region: AgrD; cl05477 1639000179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639000180 ATP binding site [chemical binding]; other site 1639000181 Mg2+ binding site [ion binding]; other site 1639000182 G-X-G motif; other site 1639000183 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1639000184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639000185 active site 1639000186 phosphorylation site [posttranslational modification] 1639000187 intermolecular recognition site; other site 1639000188 LytTr DNA-binding domain; Region: LytTR; pfam04397 1639000189 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1639000190 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1639000191 DHH family; Region: DHH; pfam01368 1639000192 DHHA1 domain; Region: DHHA1; pfam02272 1639000193 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1639000194 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1639000195 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1639000196 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1639000197 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1639000198 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1639000199 Walker A motif; other site 1639000200 ATP binding site [chemical binding]; other site 1639000201 Walker B motif; other site 1639000202 DNA binding loops [nucleotide binding] 1639000203 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1639000204 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1639000205 GDP-binding site [chemical binding]; other site 1639000206 ACT binding site; other site 1639000207 IMP binding site; other site 1639000208 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639000209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1639000210 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1639000211 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 1639000212 Predicted membrane protein [Function unknown]; Region: COG1511 1639000213 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 1639000214 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 1639000215 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1639000216 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1639000217 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 1639000218 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1639000219 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1639000220 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1639000221 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1639000222 Uncharacterized conserved protein [Function unknown]; Region: COG5444 1639000223 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1639000224 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1639000225 tetramer interface [polypeptide binding]; other site 1639000226 active site 1639000227 Mg2+/Mn2+ binding site [ion binding]; other site 1639000228 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1639000229 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1639000230 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1639000231 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1639000232 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1639000233 DNA binding site [nucleotide binding] 1639000234 active site 1639000235 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1639000236 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1639000237 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1639000238 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1639000239 NAD binding site [chemical binding]; other site 1639000240 LXG domain of WXG superfamily; Region: LXG; pfam04740 1639000241 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639000242 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1639000243 DNA binding residues [nucleotide binding] 1639000244 putative dimer interface [polypeptide binding]; other site 1639000245 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639000246 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639000247 active site 1639000248 catalytic tetrad [active] 1639000249 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000250 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639000251 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1639000252 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1639000253 F0F1 ATP synthase subunit alpha; Provisional; Region: PRK13343 1639000254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1639000255 Walker A motif; other site 1639000256 ATP binding site [chemical binding]; other site 1639000257 Walker B motif; other site 1639000258 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1639000259 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1639000260 core domain interface [polypeptide binding]; other site 1639000261 delta subunit interface [polypeptide binding]; other site 1639000262 epsilon subunit interface [polypeptide binding]; other site 1639000263 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 1639000264 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1639000265 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1639000266 alpha subunit interaction interface [polypeptide binding]; other site 1639000267 Walker A motif; other site 1639000268 ATP binding site [chemical binding]; other site 1639000269 Walker B motif; other site 1639000270 inhibitor binding site; inhibition site 1639000271 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1639000272 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; pfam02823 1639000273 gamma subunit interface [polypeptide binding]; other site 1639000274 epsilon subunit interface [polypeptide binding]; other site 1639000275 LBP interface [polypeptide binding]; other site 1639000276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000277 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1639000278 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639000279 active pocket/dimerization site; other site 1639000280 active site 1639000281 phosphorylation site [posttranslational modification] 1639000282 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1639000283 active site 1639000284 phosphorylation site [posttranslational modification] 1639000285 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1639000286 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1639000287 Domain of unknown function (DUF956); Region: DUF956; pfam06115 1639000288 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 1639000289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1639000290 dimerization interface [polypeptide binding]; other site 1639000291 putative DNA binding site [nucleotide binding]; other site 1639000292 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1639000293 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1639000294 dimer interface [polypeptide binding]; other site 1639000295 FMN binding site [chemical binding]; other site 1639000296 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1639000297 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1639000298 active site 1639000299 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1639000300 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1639000301 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1639000302 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1639000303 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639000304 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639000305 nucleotide binding site [chemical binding]; other site 1639000306 butyrate kinase; Region: butyr_kinase; TIGR02707 1639000307 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639000308 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639000309 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1639000310 Walker A/P-loop; other site 1639000311 ATP binding site [chemical binding]; other site 1639000312 Q-loop/lid; other site 1639000313 ABC transporter signature motif; other site 1639000314 Walker B; other site 1639000315 D-loop; other site 1639000316 H-loop/switch region; other site 1639000317 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639000318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639000319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639000320 Walker A/P-loop; other site 1639000321 ATP binding site [chemical binding]; other site 1639000322 Q-loop/lid; other site 1639000323 ABC transporter signature motif; other site 1639000324 Walker B; other site 1639000325 D-loop; other site 1639000326 H-loop/switch region; other site 1639000327 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1639000328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639000329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639000330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639000331 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1639000332 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1639000333 substrate binding pocket [chemical binding]; other site 1639000334 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1639000335 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1639000336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1639000338 ligand binding site [chemical binding]; other site 1639000339 flexible hinge region; other site 1639000340 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1639000341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639000342 non-specific DNA binding site [nucleotide binding]; other site 1639000343 salt bridge; other site 1639000344 sequence-specific DNA binding site [nucleotide binding]; other site 1639000345 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1639000346 Predicted secreted protein [Function unknown]; Region: COG5437 1639000347 Phage-related protein [Function unknown]; Region: COG5412 1639000348 Phage-related protein [Function unknown]; Region: COG5412 1639000349 Phage tail protein; Region: Sipho_tail; cl17486 1639000350 Phage tail protein; Region: Sipho_tail; pfam05709 1639000351 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 1639000352 Predicted membrane protein [Function unknown]; Region: COG1511 1639000353 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1639000354 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1639000355 active site 1639000356 metal binding site [ion binding]; metal-binding site 1639000357 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1639000358 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1639000359 active site 1639000360 metal binding site [ion binding]; metal-binding site 1639000361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1639000362 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1639000363 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639000364 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639000365 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639000366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH_2; cd04602 1639000367 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1639000368 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1639000369 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1639000370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1639000371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639000372 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1639000373 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1639000374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639000375 conserved gate region; other site 1639000376 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1639000377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639000378 putative PBP binding loops; other site 1639000379 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 1639000380 LXG domain of WXG superfamily; Region: LXG; pfam04740 1639000381 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1639000382 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1639000383 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1639000384 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1639000385 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639000386 Walker A/P-loop; other site 1639000387 ATP binding site [chemical binding]; other site 1639000388 Q-loop/lid; other site 1639000389 ABC transporter signature motif; other site 1639000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639000391 Walker B; other site 1639000392 D-loop; other site 1639000393 H-loop/switch region; other site 1639000394 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1639000395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1639000396 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1639000397 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1639000398 putative PBP binding regions; other site 1639000399 ABC-ATPase subunit interface; other site 1639000400 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000401 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639000402 ligand binding site [chemical binding]; other site 1639000403 flexible hinge region; other site 1639000404 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1639000405 DEAD_2; Region: DEAD_2; pfam06733 1639000406 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1639000407 sugar phosphate phosphatase; Provisional; Region: PRK10513 1639000408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000409 active site 1639000410 motif I; other site 1639000411 motif II; other site 1639000412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000413 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639000414 Collagen binding domain; Region: Collagen_bind; pfam05737 1639000415 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000416 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000417 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000418 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000419 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639000420 Collagen binding domain; Region: Collagen_bind; pfam05737 1639000421 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000422 Cna protein B-type domain; Region: Cna_B; pfam05738 1639000423 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1639000424 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1639000425 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1639000426 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1639000427 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467 1639000428 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1639000429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639000430 S-adenosylmethionine binding site [chemical binding]; other site 1639000431 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1639000432 GIY-YIG motif/motif A; other site 1639000433 putative active site [active] 1639000434 putative metal binding site [ion binding]; other site 1639000435 Predicted methyltransferases [General function prediction only]; Region: COG0313 1639000436 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1639000437 putative SAM binding site [chemical binding]; other site 1639000438 putative homodimer interface [polypeptide binding]; other site 1639000439 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1639000440 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1639000441 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1639000442 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1639000443 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1639000444 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1639000445 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1639000446 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000447 LRR adjacent; Region: LRR_adjacent; pfam08191 1639000448 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000449 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639000450 Integrase core domain; Region: rve; pfam00665 1639000451 Integrase core domain; Region: rve_3; cl15866 1639000452 Integrase core domain; Region: rve; pfam00665 1639000453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1639000454 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1639000455 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000456 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1639000457 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1639000458 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1639000459 active site 1639000460 HIGH motif; other site 1639000461 KMSKS motif; other site 1639000462 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1639000463 tRNA binding surface [nucleotide binding]; other site 1639000464 anticodon binding site; other site 1639000465 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1639000466 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1639000467 putative tRNA-binding site [nucleotide binding]; other site 1639000468 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1639000469 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639000470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639000471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639000472 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1639000473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639000474 dimer interface [polypeptide binding]; other site 1639000475 conserved gate region; other site 1639000476 putative PBP binding loops; other site 1639000477 ABC-ATPase subunit interface; other site 1639000478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639000479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639000480 dimer interface [polypeptide binding]; other site 1639000481 conserved gate region; other site 1639000482 putative PBP binding loops; other site 1639000483 ABC-ATPase subunit interface; other site 1639000484 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639000485 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639000486 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1639000487 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1639000488 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1639000489 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1639000490 active site 1639000491 catalytic site [active] 1639000492 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1639000493 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1639000494 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1639000495 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 1639000496 trimer interface [polypeptide binding]; other site 1639000497 active site 1639000498 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 1639000499 catalytic site [active] 1639000500 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1639000501 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1639000502 Ca binding site [ion binding]; other site 1639000503 active site 1639000504 catalytic site [active] 1639000505 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1639000506 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1639000507 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1639000508 active site 1639000509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1639000510 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1639000511 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1639000512 G5 domain; Region: G5; pfam07501 1639000513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1639000514 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1639000515 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1639000516 putative active site [active] 1639000517 putative metal binding site [ion binding]; other site 1639000518 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1639000519 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1639000520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639000521 S-adenosylmethionine binding site [chemical binding]; other site 1639000522 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1639000523 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1639000524 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1639000525 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1639000526 putative active site [active] 1639000527 YdjC motif; other site 1639000528 Mg binding site [ion binding]; other site 1639000529 putative homodimer interface [polypeptide binding]; other site 1639000530 pur operon repressor; Provisional; Region: PRK09213 1639000531 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1639000532 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639000533 active site 1639000534 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1639000535 HlyD family secretion protein; Region: HlyD_3; pfam13437 1639000536 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639000537 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639000538 Walker A/P-loop; other site 1639000539 ATP binding site [chemical binding]; other site 1639000540 Q-loop/lid; other site 1639000541 ABC transporter signature motif; other site 1639000542 Walker B; other site 1639000543 D-loop; other site 1639000544 H-loop/switch region; other site 1639000545 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639000546 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639000547 FtsX-like permease family; Region: FtsX; pfam02687 1639000548 regulatory protein SpoVG; Reviewed; Region: PRK13259 1639000549 regulatory protein SpoVG; Reviewed; Region: PRK13259 1639000550 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1639000551 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1639000552 Substrate binding site; other site 1639000553 Mg++ binding site; other site 1639000554 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1639000555 active site 1639000556 substrate binding site [chemical binding]; other site 1639000557 CoA binding site [chemical binding]; other site 1639000558 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1639000559 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1639000560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639000561 active site 1639000562 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000563 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639000564 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639000565 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 1639000566 active site 1639000567 catalytic site [active] 1639000568 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 1639000569 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1639000570 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1639000571 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1639000572 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1639000573 active site 1639000574 Zn binding site [ion binding]; other site 1639000575 ActA Protein; Region: ActA; pfam05058 1639000576 ActA Protein; Region: ActA; pfam05058 1639000577 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 1639000578 Zn binding site [ion binding]; other site 1639000579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1639000580 hypothetical protein; Provisional; Region: PRK01119 1639000581 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1639000582 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1639000583 active site 1639000584 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1639000585 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1639000586 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639000587 NAD binding site [chemical binding]; other site 1639000588 dimer interface [polypeptide binding]; other site 1639000589 substrate binding site [chemical binding]; other site 1639000590 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1639000591 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1639000592 5S rRNA interface [nucleotide binding]; other site 1639000593 CTC domain interface [polypeptide binding]; other site 1639000594 L16 interface [polypeptide binding]; other site 1639000595 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1639000596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639000597 Coenzyme A binding pocket [chemical binding]; other site 1639000598 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1639000599 putative active site [active] 1639000600 catalytic residue [active] 1639000601 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 1639000602 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1639000603 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639000604 ATP binding site [chemical binding]; other site 1639000605 putative Mg++ binding site [ion binding]; other site 1639000606 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639000607 nucleotide binding region [chemical binding]; other site 1639000608 ATP-binding site [chemical binding]; other site 1639000609 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1639000610 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1639000611 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1639000612 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639000613 RNA binding surface [nucleotide binding]; other site 1639000614 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1639000615 Septum formation initiator; Region: DivIC; pfam04977 1639000616 hypothetical protein; Provisional; Region: PRK08582 1639000617 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1639000618 RNA binding site [nucleotide binding]; other site 1639000619 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1639000620 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1639000621 Ligand Binding Site [chemical binding]; other site 1639000622 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1639000623 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1639000624 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639000625 active site 1639000626 FtsH Extracellular; Region: FtsH_ext; pfam06480 1639000627 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1639000628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639000629 Walker A motif; other site 1639000630 ATP binding site [chemical binding]; other site 1639000631 Walker B motif; other site 1639000632 arginine finger; other site 1639000633 Peptidase family M41; Region: Peptidase_M41; pfam01434 1639000634 pantothenate kinase; Reviewed; Region: PRK13318 1639000635 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1639000636 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1639000637 dimerization interface [polypeptide binding]; other site 1639000638 domain crossover interface; other site 1639000639 redox-dependent activation switch; other site 1639000640 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1639000641 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1639000642 dimer interface [polypeptide binding]; other site 1639000643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639000644 catalytic residue [active] 1639000645 dihydropteroate synthase; Region: DHPS; TIGR01496 1639000646 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1639000647 substrate binding pocket [chemical binding]; other site 1639000648 dimer interface [polypeptide binding]; other site 1639000649 inhibitor binding site; inhibition site 1639000650 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1639000651 homooctamer interface [polypeptide binding]; other site 1639000652 active site 1639000653 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1639000654 catalytic center binding site [active] 1639000655 ATP binding site [chemical binding]; other site 1639000656 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1639000657 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1639000658 FMN binding site [chemical binding]; other site 1639000659 active site 1639000660 catalytic residues [active] 1639000661 substrate binding site [chemical binding]; other site 1639000662 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1639000663 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1639000664 dimer interface [polypeptide binding]; other site 1639000665 putative anticodon binding site; other site 1639000666 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1639000667 motif 1; other site 1639000668 active site 1639000669 motif 2; other site 1639000670 motif 3; other site 1639000671 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1639000672 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1639000673 UvrB/uvrC motif; Region: UVR; pfam02151 1639000674 Arginine kinase [Amino acid transport and metabolism]; Region: COG3869 1639000675 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1639000676 ADP binding site [chemical binding]; other site 1639000677 phosphagen binding site; other site 1639000678 substrate specificity loop; other site 1639000679 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1639000680 Clp amino terminal domain; Region: Clp_N; pfam02861 1639000681 Clp amino terminal domain; Region: Clp_N; pfam02861 1639000682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639000683 Walker A motif; other site 1639000684 ATP binding site [chemical binding]; other site 1639000685 Walker B motif; other site 1639000686 arginine finger; other site 1639000687 UvrB/uvrC motif; Region: UVR; pfam02151 1639000688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639000689 Walker A motif; other site 1639000690 ATP binding site [chemical binding]; other site 1639000691 Walker B motif; other site 1639000692 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1639000693 DNA repair protein RadA; Provisional; Region: PRK11823 1639000694 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1639000695 Walker A motif/ATP binding site; other site 1639000696 ATP binding site [chemical binding]; other site 1639000697 Walker B motif; other site 1639000698 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1639000699 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1639000700 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1639000701 putative active site [active] 1639000702 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1639000703 substrate binding site; other site 1639000704 dimer interface; other site 1639000705 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1639000706 homotrimer interaction site [polypeptide binding]; other site 1639000707 zinc binding site [ion binding]; other site 1639000708 CDP-binding sites; other site 1639000709 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1639000710 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1639000711 HIGH motif; other site 1639000712 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1639000713 active site 1639000714 KMSKS motif; other site 1639000715 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1639000716 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1639000717 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1639000718 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1639000719 active site 1639000720 HIGH motif; other site 1639000721 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1639000722 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1639000723 KMSKS motif; other site 1639000724 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1639000725 tRNA binding surface [nucleotide binding]; other site 1639000726 anticodon binding site; other site 1639000727 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1639000728 active site 1639000729 dimerization interface [polypeptide binding]; other site 1639000730 metal binding site [ion binding]; metal-binding site 1639000731 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1639000732 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 1639000733 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1639000734 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1639000735 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1639000736 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1639000737 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1639000738 heterodimer interface [polypeptide binding]; other site 1639000739 homodimer interface [polypeptide binding]; other site 1639000740 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1639000741 mRNA/rRNA interface [nucleotide binding]; other site 1639000742 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1639000743 23S rRNA interface [nucleotide binding]; other site 1639000744 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1639000745 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1639000746 core dimer interface [polypeptide binding]; other site 1639000747 peripheral dimer interface [polypeptide binding]; other site 1639000748 L10 interface [polypeptide binding]; other site 1639000749 L11 interface [polypeptide binding]; other site 1639000750 putative EF-Tu interaction site [polypeptide binding]; other site 1639000751 putative EF-G interaction site [polypeptide binding]; other site 1639000752 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1639000753 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1639000754 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1639000755 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1639000756 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 1639000757 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1639000758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639000759 S-adenosylmethionine binding site [chemical binding]; other site 1639000760 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1639000761 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1639000762 RNA polymerase Rpb2, domain 7; Region: RNA_pol_Rpb2_7; pfam04560 1639000763 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 1639000764 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1639000765 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1639000766 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1639000767 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1639000768 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1639000769 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1639000770 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1639000771 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1639000772 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1639000773 DNA binding site [nucleotide binding] 1639000774 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1639000775 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1639000776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000777 active site 1639000778 motif I; other site 1639000779 motif II; other site 1639000780 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639000781 beta-galactosidase; Region: BGL; TIGR03356 1639000782 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000783 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000784 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000785 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000786 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000787 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639000788 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639000789 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639000790 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000791 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000792 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000793 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000794 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639000795 LRR adjacent; Region: LRR_adjacent; pfam08191 1639000796 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639000797 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639000798 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1639000799 metal binding site [ion binding]; metal-binding site 1639000800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639000801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1639000802 putative Zn2+ binding site [ion binding]; other site 1639000803 putative DNA binding site [nucleotide binding]; other site 1639000804 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1639000805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639000806 Zn binding site [ion binding]; other site 1639000807 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1639000808 Zn binding site [ion binding]; other site 1639000809 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639000810 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1639000811 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1639000812 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639000813 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1639000814 sugar phosphate phosphatase; Provisional; Region: PRK10513 1639000815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000816 active site 1639000817 motif I; other site 1639000818 motif II; other site 1639000819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639000821 Coenzyme A binding pocket [chemical binding]; other site 1639000822 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000823 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639000824 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1639000825 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1639000826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000827 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1639000828 active site 1639000829 motif I; other site 1639000830 motif II; other site 1639000831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639000832 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639000833 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639000834 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1639000835 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1639000836 Walker A/P-loop; other site 1639000837 ATP binding site [chemical binding]; other site 1639000838 Q-loop/lid; other site 1639000839 ABC transporter signature motif; other site 1639000840 Walker B; other site 1639000841 D-loop; other site 1639000842 H-loop/switch region; other site 1639000843 TOBE domain; Region: TOBE; pfam03459 1639000844 ATP cone domain; Region: ATP-cone; pfam03477 1639000845 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1639000846 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1639000847 active site 1639000848 Zn binding site [ion binding]; other site 1639000849 glycine loop; other site 1639000850 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1639000851 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1639000852 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639000853 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1639000854 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1639000855 putative active site [active] 1639000856 catalytic triad [active] 1639000857 putative dimer interface [polypeptide binding]; other site 1639000858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639000859 dimer interface [polypeptide binding]; other site 1639000860 conserved gate region; other site 1639000861 ABC-ATPase subunit interface; other site 1639000862 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1639000863 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639000864 Walker A/P-loop; other site 1639000865 ATP binding site [chemical binding]; other site 1639000866 Q-loop/lid; other site 1639000867 ABC transporter signature motif; other site 1639000868 Walker B; other site 1639000869 D-loop; other site 1639000870 H-loop/switch region; other site 1639000871 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1639000872 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1639000873 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639000874 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639000875 homodimer interface [polypeptide binding]; other site 1639000876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639000877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639000878 active site 1639000879 phosphorylation site [posttranslational modification] 1639000880 intermolecular recognition site; other site 1639000881 dimerization interface [polypeptide binding]; other site 1639000882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639000883 DNA binding site [nucleotide binding] 1639000884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639000885 dimerization interface [polypeptide binding]; other site 1639000886 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1639000887 putative active site [active] 1639000888 heme pocket [chemical binding]; other site 1639000889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1639000890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639000891 dimer interface [polypeptide binding]; other site 1639000892 phosphorylation site [posttranslational modification] 1639000893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639000894 ATP binding site [chemical binding]; other site 1639000895 Mg2+ binding site [ion binding]; other site 1639000896 G-X-G motif; other site 1639000897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1639000898 YycH protein; Region: YycH; pfam07435 1639000899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4853 1639000900 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1639000901 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1639000902 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1639000903 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639000904 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639000905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1639000906 dimerization interface [polypeptide binding]; other site 1639000907 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1639000908 dimer interface [polypeptide binding]; other site 1639000909 FMN binding site [chemical binding]; other site 1639000910 NADPH bind site [chemical binding]; other site 1639000911 HTH domain; Region: HTH_11; pfam08279 1639000912 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639000913 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639000914 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1639000915 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639000916 active site 1639000917 P-loop; other site 1639000918 phosphorylation site [posttranslational modification] 1639000919 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639000920 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639000921 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639000922 methionine cluster; other site 1639000923 active site 1639000924 phosphorylation site [posttranslational modification] 1639000925 metal binding site [ion binding]; metal-binding site 1639000926 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639000927 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639000928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639000929 catalytic residue [active] 1639000930 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1639000931 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1639000932 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1639000933 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1639000934 ATP binding site [chemical binding]; other site 1639000935 substrate binding site [chemical binding]; other site 1639000936 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1639000937 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639000938 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639000939 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1639000940 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 1639000941 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1639000942 putative catalytic site [active] 1639000943 putative metal binding site [ion binding]; other site 1639000944 putative phosphate binding site [ion binding]; other site 1639000945 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1639000946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639000947 non-specific DNA binding site [nucleotide binding]; other site 1639000948 salt bridge; other site 1639000949 sequence-specific DNA binding site [nucleotide binding]; other site 1639000950 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639000951 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639000952 non-specific DNA binding site [nucleotide binding]; other site 1639000953 salt bridge; other site 1639000954 sequence-specific DNA binding site [nucleotide binding]; other site 1639000955 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639000956 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639000957 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000958 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000959 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000960 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000961 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000962 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000963 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000964 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000965 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1639000967 Homeodomain-like domain; Region: HTH_23; cl17451 1639000968 HTH-like domain; Region: HTH_21; pfam13276 1639000969 Integrase core domain; Region: rve; pfam00665 1639000970 Integrase core domain; Region: rve_3; cl15866 1639000971 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639000972 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1639000973 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000974 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000975 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639000976 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639000977 Flavodoxin domain; Region: Flavodoxin_5; pfam12724 1639000978 Inorganic pyrophosphatase [Energy production and conversion]; Region: Ppa; COG0221 1639000979 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1639000980 PYR/PP interface [polypeptide binding]; other site 1639000981 TPP binding site [chemical binding]; other site 1639000982 dimer interface [polypeptide binding]; other site 1639000983 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639000984 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1639000985 TPP-binding site [chemical binding]; other site 1639000986 dimer interface [polypeptide binding]; other site 1639000987 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1639000988 active site 1639000989 intersubunit interactions; other site 1639000990 catalytic residue [active] 1639000991 short chain dehydrogenase; Provisional; Region: PRK06841 1639000992 classical (c) SDRs; Region: SDR_c; cd05233 1639000993 NAD(P) binding site [chemical binding]; other site 1639000994 active site 1639000995 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1639000996 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1639000997 substrate binding site [chemical binding]; other site 1639000998 dimer interface [polypeptide binding]; other site 1639000999 catalytic triad [active] 1639001000 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1639001001 DAK2 domain; Region: Dak2; cl03685 1639001002 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1639001003 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1639001004 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639001005 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1639001006 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639001007 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639001008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639001009 Coenzyme A binding pocket [chemical binding]; other site 1639001010 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1639001011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639001012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639001013 acyl-activating enzyme (AAE) consensus motif; other site 1639001014 acyl-activating enzyme (AAE) consensus motif; other site 1639001015 AMP binding site [chemical binding]; other site 1639001016 active site 1639001017 CoA binding site [chemical binding]; other site 1639001018 fumarate reductase flavoprotein subunit; Validated; Region: PRK06481 1639001019 L-aspartate oxidase; Provisional; Region: PRK06175 1639001020 putative oxidoreductase; Provisional; Region: PRK10206 1639001021 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639001022 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1639001023 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001024 active site 1639001025 phosphorylation site [posttranslational modification] 1639001026 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1639001027 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639001028 active site 1639001029 P-loop; other site 1639001030 phosphorylation site [posttranslational modification] 1639001031 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639001032 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1639001033 intersubunit interface [polypeptide binding]; other site 1639001034 active site 1639001035 zinc binding site [ion binding]; other site 1639001036 Na+ binding site [ion binding]; other site 1639001037 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639001038 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1639001039 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639001040 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1639001041 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1639001042 conserved cys residue [active] 1639001043 Predicted transcriptional regulator [Transcription]; Region: COG2378 1639001044 HTH domain; Region: HTH_11; pfam08279 1639001045 WYL domain; Region: WYL; pfam13280 1639001046 Iron permease FTR1 family; Region: FTR1; cl00475 1639001047 Iron permease FTR1 family; Region: FTR1; cl00475 1639001048 Imelysin; Region: Peptidase_M75; pfam09375 1639001049 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1639001050 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1639001051 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1639001052 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1639001053 Transcriptional regulator; Region: Transcrip_reg; cl00361 1639001054 Transcriptional regulator; Region: Transcrip_reg; cl00361 1639001055 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1639001056 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1639001057 PhnA protein; Region: PhnA; pfam03831 1639001058 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639001059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639001060 DNA-binding site [nucleotide binding]; DNA binding site 1639001061 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639001062 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001063 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001064 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639001065 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1639001066 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639001067 active site 1639001068 P-loop; other site 1639001069 phosphorylation site [posttranslational modification] 1639001070 Predicted transcriptional regulator [Transcription]; Region: COG2378 1639001071 HTH domain; Region: HTH_11; pfam08279 1639001072 WYL domain; Region: WYL; pfam13280 1639001073 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1639001074 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1639001075 tetrameric interface [polypeptide binding]; other site 1639001076 NAD binding site [chemical binding]; other site 1639001077 catalytic residues [active] 1639001078 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1639001079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1639001080 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1639001081 substrate binding site [chemical binding]; other site 1639001082 ATP binding site [chemical binding]; other site 1639001083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1639001084 PYR/PP interface [polypeptide binding]; other site 1639001085 dimer interface [polypeptide binding]; other site 1639001086 TPP binding site [chemical binding]; other site 1639001087 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1639001088 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1639001089 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1639001090 TPP-binding site; other site 1639001091 Domain of unknown function (DU1801); Region: DUF1801; cl17490 1639001092 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1639001093 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1639001094 ligand binding site [chemical binding]; other site 1639001095 active site 1639001096 UGI interface [polypeptide binding]; other site 1639001097 catalytic site [active] 1639001098 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1639001099 hypothetical protein; Provisional; Region: PRK13665 1639001100 NlpC/P60 family; Region: NLPC_P60; pfam00877 1639001101 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1639001102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639001103 Coenzyme A binding pocket [chemical binding]; other site 1639001104 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1639001105 pyrroline-5-carboxylate reductase; Region: PLN02688 1639001106 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1639001107 putative hydrophobic ligand binding site [chemical binding]; other site 1639001108 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001109 active site 1639001110 phosphorylation site [posttranslational modification] 1639001111 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639001112 active site 1639001113 P-loop; other site 1639001114 phosphorylation site [posttranslational modification] 1639001115 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639001116 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639001117 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639001118 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1639001119 alpha-mannosidase; Provisional; Region: PRK09819 1639001120 alpha-mannosidase; Provisional; Region: PRK09819 1639001121 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639001122 HTH domain; Region: HTH_11; pfam08279 1639001123 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639001124 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639001125 PRD domain; Region: PRD; pfam00874 1639001126 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639001127 active site 1639001128 P-loop; other site 1639001129 phosphorylation site [posttranslational modification] 1639001130 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001131 active site 1639001132 phosphorylation site [posttranslational modification] 1639001133 Phosphate transporter family; Region: PHO4; pfam01384 1639001134 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1639001135 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639001136 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639001137 active site 1639001138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 1639001139 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1639001140 trimer interface [polypeptide binding]; other site 1639001141 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1639001142 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1639001143 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1639001144 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1639001145 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1639001146 ZIP Zinc transporter; Region: Zip; pfam02535 1639001147 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1639001148 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 1639001149 NodB motif; other site 1639001150 active site 1639001151 catalytic site [active] 1639001152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639001153 non-specific DNA binding site [nucleotide binding]; other site 1639001154 salt bridge; other site 1639001155 sequence-specific DNA binding site [nucleotide binding]; other site 1639001156 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1639001157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639001158 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1639001159 active site 1639001160 motif I; other site 1639001161 motif II; other site 1639001162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639001163 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1639001164 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1639001165 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1639001166 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 1639001167 Predicted transcriptional regulators [Transcription]; Region: COG1695 1639001168 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1639001169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1639001170 DNA binding residues [nucleotide binding] 1639001171 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1639001172 HTH domain; Region: HTH_11; pfam08279 1639001173 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639001174 PRD domain; Region: PRD; pfam00874 1639001175 PRD domain; Region: PRD; pfam00874 1639001176 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639001177 active site 1639001178 P-loop; other site 1639001179 phosphorylation site [posttranslational modification] 1639001180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001181 active site 1639001182 phosphorylation site [posttranslational modification] 1639001183 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001184 active site 1639001185 phosphorylation site [posttranslational modification] 1639001186 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639001187 active site 1639001188 P-loop; other site 1639001189 phosphorylation site [posttranslational modification] 1639001190 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639001191 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639001192 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639001193 alpha-mannosidase; Provisional; Region: PRK09819 1639001194 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1639001195 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1639001196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639001197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639001198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1639001199 dimerization interface [polypeptide binding]; other site 1639001200 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1639001201 CoA binding site [chemical binding]; other site 1639001202 active site 1639001203 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1639001204 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1639001205 classical (c) SDRs; Region: SDR_c; cd05233 1639001206 NAD(P) binding site [chemical binding]; other site 1639001207 active site 1639001208 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639001209 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001210 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001211 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001212 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001213 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001214 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001215 LRR adjacent; Region: LRR_adjacent; pfam08191 1639001216 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639001217 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639001218 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639001219 Leucine rich repeat; Region: LRR_8; pfam13855 1639001220 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1639001221 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001222 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001223 LRR adjacent; Region: LRR_adjacent; pfam08191 1639001224 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639001225 SH3-like domain; Region: SH3_8; pfam13457 1639001226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639001227 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1639001228 NAD(P) binding site [chemical binding]; other site 1639001229 active site 1639001230 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1639001231 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1639001232 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 1639001233 Protein of unknown function (DUF2004); Region: DUF2004; pfam09406 1639001234 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1639001235 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1639001236 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1639001237 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 1639001238 Predicted membrane protein [Function unknown]; Region: COG3619 1639001239 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1639001240 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1639001241 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1639001242 Protein of unknown function DUF58; Region: DUF58; pfam01882 1639001243 MoxR-like ATPases [General function prediction only]; Region: COG0714 1639001244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639001245 Walker A motif; other site 1639001246 ATP binding site [chemical binding]; other site 1639001247 Walker B motif; other site 1639001248 arginine finger; other site 1639001249 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1639001250 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 1639001251 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1639001252 Na binding site [ion binding]; other site 1639001253 Uncharacterized conserved protein [Function unknown]; Region: COG3535 1639001254 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639001255 nucleotide binding site [chemical binding]; other site 1639001256 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1639001257 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1639001258 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1639001259 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639001260 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1639001261 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001262 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001263 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001264 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 1639001265 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001266 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001267 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001268 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001269 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 1639001270 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1639001271 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1639001272 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 1639001273 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1639001274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639001275 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1639001276 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1639001277 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1639001278 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1639001279 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl17487 1639001280 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1639001281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1639001282 FeS/SAM binding site; other site 1639001283 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1639001284 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1639001285 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13316 1639001286 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1639001287 putative FMN binding site [chemical binding]; other site 1639001288 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1639001289 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639001290 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639001291 phosphate binding site [ion binding]; other site 1639001292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639001293 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639001294 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1639001295 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1639001296 NAD(P) binding site [chemical binding]; other site 1639001297 shikimate binding site; other site 1639001298 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1639001299 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1639001300 active site 1639001301 catalytic residue [active] 1639001302 dimer interface [polypeptide binding]; other site 1639001303 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1639001304 active site 1639001305 catalytic triad [active] 1639001306 oxyanion hole [active] 1639001307 EamA-like transporter family; Region: EamA; pfam00892 1639001308 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1639001309 EamA-like transporter family; Region: EamA; pfam00892 1639001310 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1639001311 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1639001312 active site 1639001313 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1639001314 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1639001315 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1639001316 substrate binding site [chemical binding]; other site 1639001317 hexamer interface [polypeptide binding]; other site 1639001318 metal binding site [ion binding]; metal-binding site 1639001319 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639001320 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639001321 catalytic residue [active] 1639001322 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639001323 PRD domain; Region: PRD; pfam00874 1639001324 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639001325 active site 1639001326 P-loop; other site 1639001327 phosphorylation site [posttranslational modification] 1639001328 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001329 active site 1639001330 phosphorylation site [posttranslational modification] 1639001331 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1639001332 putative active site [active] 1639001333 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001334 active site 1639001335 phosphorylation site [posttranslational modification] 1639001336 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1639001337 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1639001338 substrate binding site [chemical binding]; other site 1639001339 hexamer interface [polypeptide binding]; other site 1639001340 metal binding site [ion binding]; metal-binding site 1639001341 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1639001342 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639001343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1639001344 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1639001345 active site 1639001346 P-loop; other site 1639001347 phosphorylation site [posttranslational modification] 1639001348 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1639001349 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1639001350 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1639001351 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1639001352 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639001353 active site 1639001354 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1639001355 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1639001356 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1639001357 catalytic triad [active] 1639001358 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 1639001359 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639001360 MarR family; Region: MarR_2; pfam12802 1639001361 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001362 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1639001363 Ligand Binding Site [chemical binding]; other site 1639001364 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1639001365 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1639001366 putative active site [active] 1639001367 putative metal binding site [ion binding]; other site 1639001368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639001369 catalytic core [active] 1639001370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639001371 Predicted membrane protein [Function unknown]; Region: COG3759 1639001372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639001373 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639001374 putative substrate translocation pore; other site 1639001375 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1639001376 non-specific DNA interactions [nucleotide binding]; other site 1639001377 DNA binding site [nucleotide binding] 1639001378 sequence specific DNA binding site [nucleotide binding]; other site 1639001379 putative cAMP binding site [chemical binding]; other site 1639001380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639001381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639001382 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1639001383 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1639001384 sugar binding site [chemical binding]; other site 1639001385 divalent metal binding site [ion binding]; other site 1639001386 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639001387 dimer interface [polypeptide binding]; other site 1639001388 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1639001389 LDH/MDH dimer interface [polypeptide binding]; other site 1639001390 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639001391 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1639001392 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1639001393 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1639001394 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1639001395 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1639001396 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1639001397 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1639001398 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1639001399 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1639001400 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1639001401 DNA binding residues [nucleotide binding] 1639001402 dimer interface [polypeptide binding]; other site 1639001403 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1639001404 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1639001405 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1639001406 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1639001407 DXD motif; other site 1639001408 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1639001409 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1639001410 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1639001411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639001412 S-adenosylmethionine binding site [chemical binding]; other site 1639001413 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1639001414 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1639001415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639001416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639001417 DNA binding site [nucleotide binding] 1639001418 domain linker motif; other site 1639001419 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1639001420 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1639001421 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1639001422 NAD binding site [chemical binding]; other site 1639001423 sugar binding site [chemical binding]; other site 1639001424 divalent metal binding site [ion binding]; other site 1639001425 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1639001426 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639001427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639001428 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639001429 Beta-lactamase; Region: Beta-lactamase; pfam00144 1639001430 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1639001431 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1639001432 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1639001433 intersubunit interface [polypeptide binding]; other site 1639001434 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 1639001435 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 1639001436 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1639001437 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1639001438 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 1639001439 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1639001440 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 1639001441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639001442 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 1639001443 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1639001444 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1639001445 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639001446 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001447 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001448 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001449 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1639001450 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639001451 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1639001452 FOG: CBS domain [General function prediction only]; Region: COG0517 1639001453 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1639001454 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1639001455 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1639001456 dimer interface [polypeptide binding]; other site 1639001457 active site 1639001458 metal binding site [ion binding]; metal-binding site 1639001459 POT family; Region: PTR2; cl17359 1639001460 POT family; Region: PTR2; cl17359 1639001461 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639001462 catalytic core [active] 1639001463 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 1639001464 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1639001465 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1639001466 Cl binding site [ion binding]; other site 1639001467 oligomer interface [polypeptide binding]; other site 1639001468 glutamate dehydrogenase; Provisional; Region: PRK09414 1639001469 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1639001470 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1639001471 NAD(P) binding site [chemical binding]; other site 1639001472 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1639001473 metal binding site [ion binding]; metal-binding site 1639001474 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1639001475 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1639001476 imidazole glycerol phosphate synthase subunit HisF; Provisional; Region: PRK02083 1639001477 phosphate binding site [ion binding]; other site 1639001478 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639001479 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1639001480 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639001481 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1639001482 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1639001483 catalytic triad [active] 1639001484 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 1639001485 4-fold oligomerization interface [polypeptide binding]; other site 1639001486 metal binding residues [ion binding]; metal-binding site 1639001487 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 1639001488 putative active site pocket [active] 1639001489 metal binding residues [ion binding]; metal-binding site 1639001490 histidinol dehydrogenase; Region: hisD; TIGR00069 1639001491 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1639001492 NAD binding site [chemical binding]; other site 1639001493 dimerization interface [polypeptide binding]; other site 1639001494 product binding site; other site 1639001495 substrate binding site [chemical binding]; other site 1639001496 zinc binding site [ion binding]; other site 1639001497 catalytic residues [active] 1639001498 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1639001499 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1639001500 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1639001501 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1639001502 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1639001503 dimer interface [polypeptide binding]; other site 1639001504 motif 1; other site 1639001505 active site 1639001506 motif 2; other site 1639001507 motif 3; other site 1639001508 histidinol-phosphatase; Reviewed; Region: PRK08123 1639001509 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1639001510 active site 1639001511 dimer interface [polypeptide binding]; other site 1639001512 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1639001513 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1639001514 DNA binding site [nucleotide binding] 1639001515 active site 1639001516 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 1639001517 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1639001518 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1639001519 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001520 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001521 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001522 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639001523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639001524 DNA-binding site [nucleotide binding]; DNA binding site 1639001525 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639001526 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639001527 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639001528 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1639001529 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1639001530 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1639001531 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1639001532 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1639001533 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1639001534 Predicted esterase [General function prediction only]; Region: COG0400 1639001535 putative hydrolase; Provisional; Region: PRK11460 1639001536 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1639001537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639001538 S-adenosylmethionine binding site [chemical binding]; other site 1639001539 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1639001540 putative RNA binding site [nucleotide binding]; other site 1639001541 invasion associated secreted endopeptidase; Provisional; Region: PRK13914 1639001542 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1639001543 Bacterial SH3 domain; Region: SH3_3; pfam08239 1639001544 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1639001545 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 1639001546 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639001547 ATP binding site [chemical binding]; other site 1639001548 putative Mg++ binding site [ion binding]; other site 1639001549 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1639001550 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1639001551 nucleotide binding region [chemical binding]; other site 1639001552 ATP-binding site [chemical binding]; other site 1639001553 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1639001554 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1639001555 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1639001556 WxL domain surface cell wall-binding; Region: WxL; pfam13731 1639001557 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 1639001558 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 1639001559 DNA photolyase; Region: DNA_photolyase; pfam00875 1639001560 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1639001561 Predicted membrane protein (DUF2177); Region: DUF2177; cl02014 1639001562 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 1639001563 DAK2 domain; Region: Dak2; pfam02734 1639001564 EDD domain protein, DegV family; Region: DegV; TIGR00762 1639001565 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1639001566 Steroid 5-alpha reductase family enzyme [General function prediction only]; Region: COG3752 1639001567 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1639001568 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1639001569 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1639001570 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1639001571 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1639001572 homodimer interface [polypeptide binding]; other site 1639001573 substrate-cofactor binding pocket; other site 1639001574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639001575 catalytic residue [active] 1639001576 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1639001577 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639001578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1639001579 ligand binding site [chemical binding]; other site 1639001580 flexible hinge region; other site 1639001581 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639001582 BioY family; Region: BioY; pfam02632 1639001583 Predicted transcriptional regulators [Transcription]; Region: COG1695 1639001584 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1639001585 Predicted membrane protein [Function unknown]; Region: COG4709 1639001586 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1639001587 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1639001588 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1639001589 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1639001590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1639001591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639001592 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1639001593 Coenzyme A binding pocket [chemical binding]; other site 1639001594 Tic20-like protein; Region: Tic20; pfam09685 1639001595 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639001596 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639001597 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1639001598 MarR family; Region: MarR_2; pfam12802 1639001599 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639001600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639001601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001602 Walker A/P-loop; other site 1639001603 ATP binding site [chemical binding]; other site 1639001604 Q-loop/lid; other site 1639001605 ABC transporter signature motif; other site 1639001606 Walker B; other site 1639001607 D-loop; other site 1639001608 H-loop/switch region; other site 1639001609 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639001610 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1639001611 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1639001612 Walker A/P-loop; other site 1639001613 ATP binding site [chemical binding]; other site 1639001614 Q-loop/lid; other site 1639001615 ABC transporter signature motif; other site 1639001616 Walker B; other site 1639001617 D-loop; other site 1639001618 H-loop/switch region; other site 1639001619 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1639001620 active site residue [active] 1639001621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001622 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639001623 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1639001624 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1639001625 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1639001626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1639001627 putative DNA binding site [nucleotide binding]; other site 1639001628 putative Zn2+ binding site [ion binding]; other site 1639001629 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1639001630 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1639001631 putative NAD(P) binding site [chemical binding]; other site 1639001632 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1639001633 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1639001634 Coenzyme A binding pocket [chemical binding]; other site 1639001635 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 1639001636 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1639001637 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1639001638 putative active site [active] 1639001639 catalytic site [active] 1639001640 putative metal binding site [ion binding]; other site 1639001641 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1639001642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1639001643 active site 1639001644 ATP binding site [chemical binding]; other site 1639001645 substrate binding site [chemical binding]; other site 1639001646 activation loop (A-loop); other site 1639001647 Eukaryotic protein of unknown function (DUF872); Region: DUF872; pfam05915 1639001648 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1639001649 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1639001650 active site 1639001651 catalytic triad [active] 1639001652 oxyanion hole [active] 1639001653 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1639001654 domain interaction interfaces [polypeptide binding]; other site 1639001655 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1639001656 domain interaction interfaces [polypeptide binding]; other site 1639001657 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1639001658 domain interaction interfaces [polypeptide binding]; other site 1639001659 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 1639001660 domain interaction interfaces [polypeptide binding]; other site 1639001661 Isochorismatase family; Region: Isochorismatase; pfam00857 1639001662 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1639001663 catalytic triad [active] 1639001664 conserved cis-peptide bond; other site 1639001665 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639001666 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639001667 PRD domain; Region: PRD; pfam00874 1639001668 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639001669 active site 1639001670 P-loop; other site 1639001671 phosphorylation site [posttranslational modification] 1639001672 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1639001673 active site 1639001674 phosphorylation site [posttranslational modification] 1639001675 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639001676 active site 1639001677 phosphorylation site [posttranslational modification] 1639001678 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1639001679 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639001680 active site 1639001681 P-loop; other site 1639001682 phosphorylation site [posttranslational modification] 1639001683 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 1639001684 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1639001685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639001686 motif II; other site 1639001687 Transcriptional regulator; Region: Rrf2; pfam02082 1639001688 Predicted transcriptional regulator [Transcription]; Region: COG1959 1639001689 Transcriptional regulator; Region: Rrf2; pfam02082 1639001690 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639001691 S-adenosylmethionine binding site [chemical binding]; other site 1639001692 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1639001693 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639001694 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639001695 active site 1639001696 catalytic tetrad [active] 1639001697 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1639001698 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639001699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639001700 motif II; other site 1639001701 Transaldolase [Carbohydrate transport and metabolism]; Region: MipB; COG0176 1639001702 catalytic residue [active] 1639001703 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1639001704 Sulfatase; Region: Sulfatase; pfam00884 1639001705 amino acid transporter; Region: 2A0306; TIGR00909 1639001706 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1639001707 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1639001708 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1639001709 putative metal binding site [ion binding]; other site 1639001710 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639001711 active site 1639001712 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1639001713 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1639001714 Cl binding site [ion binding]; other site 1639001715 oligomer interface [polypeptide binding]; other site 1639001716 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1639001717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639001718 DNA-binding site [nucleotide binding]; DNA binding site 1639001719 Predicted membrane protein [Function unknown]; Region: COG1511 1639001720 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1639001721 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1639001722 linker region; other site 1639001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639001724 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1639001725 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639001726 DNA-binding site [nucleotide binding]; DNA binding site 1639001727 FCD domain; Region: FCD; cl11656 1639001728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1639001729 Predicted integral membrane protein [Function unknown]; Region: COG5523 1639001730 Predicted membrane protein [Function unknown]; Region: COG2322 1639001731 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1639001732 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1639001733 minor groove reading motif; other site 1639001734 helix-hairpin-helix signature motif; other site 1639001735 substrate binding pocket [chemical binding]; other site 1639001736 active site 1639001737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639001738 non-specific DNA binding site [nucleotide binding]; other site 1639001739 salt bridge; other site 1639001740 sequence-specific DNA binding site [nucleotide binding]; other site 1639001741 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639001742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1639001743 Helix-turn-helix domain; Region: HTH_28; pfam13518 1639001744 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1639001745 ATP binding site [chemical binding]; other site 1639001746 substrate binding site [chemical binding]; other site 1639001747 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1639001748 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639001749 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639001750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639001751 active site 1639001752 motif I; other site 1639001753 motif II; other site 1639001754 maltose O-acetyltransferase; Provisional; Region: PRK10092 1639001755 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1639001756 active site 1639001757 substrate binding site [chemical binding]; other site 1639001758 trimer interface [polypeptide binding]; other site 1639001759 CoA binding site [chemical binding]; other site 1639001760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001761 Walker A/P-loop; other site 1639001762 ATP binding site [chemical binding]; other site 1639001763 ABC transporter; Region: ABC_tran; pfam00005 1639001764 Q-loop/lid; other site 1639001765 ABC transporter signature motif; other site 1639001766 Walker B; other site 1639001767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001768 H-loop/switch region; other site 1639001769 inner membrane transport permease; Provisional; Region: PRK15066 1639001770 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1639001771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1639001772 Predicted membrane protein [Function unknown]; Region: COG3152 1639001773 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 1639001774 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 1639001775 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 1639001776 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; COG1377 1639001777 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1639001778 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1639001779 FHIPEP family; Region: FHIPEP; pfam00771 1639001780 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12726 1639001781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639001782 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1639001783 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1639001784 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1639001785 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1639001786 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1639001787 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 1639001788 flagellar motor protein MotA; Validated; Region: PRK08124 1639001789 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1639001790 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1639001791 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1639001792 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1639001793 ligand binding site [chemical binding]; other site 1639001794 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1639001795 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1639001796 putative metal binding site; other site 1639001797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639001798 binding surface 1639001799 TPR motif; other site 1639001800 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1639001801 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1639001802 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1639001803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639001804 active site 1639001805 phosphorylation site [posttranslational modification] 1639001806 intermolecular recognition site; other site 1639001807 dimerization interface [polypeptide binding]; other site 1639001808 flagellin; Provisional; Region: PRK12805 1639001809 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1639001810 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1639001811 Response regulator receiver domain; Region: Response_reg; pfam00072 1639001812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639001813 active site 1639001814 phosphorylation site [posttranslational modification] 1639001815 intermolecular recognition site; other site 1639001816 dimerization interface [polypeptide binding]; other site 1639001817 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1639001818 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1639001819 putative binding surface; other site 1639001820 active site 1639001821 P2 response regulator binding domain; Region: P2; pfam07194 1639001822 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1639001823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639001824 ATP binding site [chemical binding]; other site 1639001825 Mg2+ binding site [ion binding]; other site 1639001826 G-X-G motif; other site 1639001827 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1639001828 flagellar motor switch protein; Validated; Region: PRK06788 1639001829 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1639001830 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK11911 1639001831 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1639001832 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1639001833 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1639001834 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1639001835 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1639001836 flagellar motor switch protein; Validated; Region: PRK06789 1639001837 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1639001838 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1639001839 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1639001840 CheC-like family; Region: CheC; pfam04509 1639001841 CheC-like family; Region: CheC; pfam04509 1639001842 Chemotaxis phosphatase CheX; Region: CheX; cl15816 1639001843 CheC-like family; Region: CheC; pfam04509 1639001844 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1639001845 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1639001846 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 1639001847 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1639001848 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 1639001849 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1639001850 flagellar capping protein; Validated; Region: fliD; PRK06798 1639001851 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1639001852 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1639001853 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1639001854 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 1639001855 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 1639001856 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1639001857 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 1639001858 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 1639001859 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1639001860 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1639001861 flagellar assembly protein H; Validated; Region: fliH; PRK06800 1639001862 Flagellar assembly protein FliH; Region: FliH; pfam02108 1639001863 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 1639001864 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1639001865 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1639001866 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1639001867 catalytic residue [active] 1639001868 Predicted transcriptional regulators [Transcription]; Region: COG1695 1639001869 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1639001870 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1639001871 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1639001872 pyruvate oxidase; Provisional; Region: PRK08611 1639001873 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1639001874 PYR/PP interface [polypeptide binding]; other site 1639001875 dimer interface [polypeptide binding]; other site 1639001876 tetramer interface [polypeptide binding]; other site 1639001877 TPP binding site [chemical binding]; other site 1639001878 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1639001879 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1639001880 TPP-binding site [chemical binding]; other site 1639001881 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1639001882 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1639001883 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639001884 dimerization interface [polypeptide binding]; other site 1639001885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1639001886 dimer interface [polypeptide binding]; other site 1639001887 putative CheW interface [polypeptide binding]; other site 1639001888 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1639001889 putative active site [active] 1639001890 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1639001891 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1639001892 active site 1639001893 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1639001894 GIY-YIG motif/motif A; other site 1639001895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1639001896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639001897 non-specific DNA binding site [nucleotide binding]; other site 1639001898 salt bridge; other site 1639001899 sequence-specific DNA binding site [nucleotide binding]; other site 1639001900 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639001901 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639001902 DNA binding site [nucleotide binding] 1639001903 domain linker motif; other site 1639001904 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639001905 ligand binding site [chemical binding]; other site 1639001906 dimerization interface [polypeptide binding]; other site 1639001907 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1639001908 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1639001909 substrate binding site [chemical binding]; other site 1639001910 hexamer interface [polypeptide binding]; other site 1639001911 metal binding site [ion binding]; metal-binding site 1639001912 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1639001913 BtpA family; Region: BtpA; cl00440 1639001914 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639001915 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1639001916 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639001917 active site turn [active] 1639001918 phosphorylation site [posttranslational modification] 1639001919 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639001920 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1639001921 HPr interaction site; other site 1639001922 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639001923 active site 1639001924 phosphorylation site [posttranslational modification] 1639001925 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639001926 beta-galactosidase; Region: BGL; TIGR03356 1639001927 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639001928 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639001929 ligand binding site [chemical binding]; other site 1639001930 flexible hinge region; other site 1639001931 Predicted transcriptional regulators [Transcription]; Region: COG1725 1639001932 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639001933 DNA-binding site [nucleotide binding]; DNA binding site 1639001934 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1639001935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001936 Walker A/P-loop; other site 1639001937 ATP binding site [chemical binding]; other site 1639001938 Q-loop/lid; other site 1639001939 ABC transporter signature motif; other site 1639001940 Walker B; other site 1639001941 D-loop; other site 1639001942 H-loop/switch region; other site 1639001943 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639001944 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1639001945 FtsX-like permease family; Region: FtsX; pfam02687 1639001946 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1639001947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639001948 non-specific DNA binding site [nucleotide binding]; other site 1639001949 salt bridge; other site 1639001950 sequence-specific DNA binding site [nucleotide binding]; other site 1639001951 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1639001952 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639001953 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1639001954 ligand binding site [chemical binding]; other site 1639001955 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1639001956 non-specific DNA interactions [nucleotide binding]; other site 1639001957 DNA binding site [nucleotide binding] 1639001958 sequence specific DNA binding site [nucleotide binding]; other site 1639001959 putative cAMP binding site [chemical binding]; other site 1639001960 SnoaL-like domain; Region: SnoaL_4; pfam13577 1639001961 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1639001962 oxyanion hole [active] 1639001963 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1639001964 active site 1639001965 catalytic triad [active] 1639001966 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001967 Walker A/P-loop; other site 1639001968 ATP binding site [chemical binding]; other site 1639001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639001970 ABC transporter signature motif; other site 1639001971 Walker B; other site 1639001972 D-loop; other site 1639001973 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1639001974 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639001975 active site 1639001976 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1639001977 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639001978 Zn binding site [ion binding]; other site 1639001979 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1639001980 Zn binding site [ion binding]; other site 1639001981 Predicted esterase [General function prediction only]; Region: COG0400 1639001982 putative hydrolase; Provisional; Region: PRK11460 1639001983 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1639001984 GTPases [General function prediction only]; Region: HflX; COG2262 1639001985 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1639001986 HflX GTPase family; Region: HflX; cd01878 1639001987 G1 box; other site 1639001988 GTP/Mg2+ binding site [chemical binding]; other site 1639001989 Switch I region; other site 1639001990 G2 box; other site 1639001991 G3 box; other site 1639001992 Switch II region; other site 1639001993 G4 box; other site 1639001994 G5 box; other site 1639001995 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1639001996 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1639001997 putative active site [active] 1639001998 putative metal binding site [ion binding]; other site 1639001999 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1639002000 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1639002001 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1639002002 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1639002003 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1639002004 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1639002005 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1639002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002007 dimer interface [polypeptide binding]; other site 1639002008 conserved gate region; other site 1639002009 putative PBP binding loops; other site 1639002010 ABC-ATPase subunit interface; other site 1639002011 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002013 dimer interface [polypeptide binding]; other site 1639002014 conserved gate region; other site 1639002015 putative PBP binding loops; other site 1639002016 ABC-ATPase subunit interface; other site 1639002017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639002018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1639002019 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1639002020 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1639002021 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1639002022 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639002023 DNA-binding site [nucleotide binding]; DNA binding site 1639002024 Yhfp putative quinone oxidoreductases; Region: MDR_yhfp_like; cd08289 1639002025 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1639002026 putative NADP binding site [chemical binding]; other site 1639002027 putative dimer interface [polypeptide binding]; other site 1639002028 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1639002029 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1639002030 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639002031 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639002032 nucleotide binding site [chemical binding]; other site 1639002033 Predicted membrane protein [Function unknown]; Region: COG4811 1639002034 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1639002035 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1639002036 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1639002037 active site 1639002038 phosphorylation site [posttranslational modification] 1639002039 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639002040 active pocket/dimerization site; other site 1639002041 active site 1639002042 phosphorylation site [posttranslational modification] 1639002043 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1639002044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639002045 Walker A motif; other site 1639002046 ATP binding site [chemical binding]; other site 1639002047 Walker B motif; other site 1639002048 arginine finger; other site 1639002049 Transcriptional antiterminator [Transcription]; Region: COG3933 1639002050 PRD domain; Region: PRD; pfam00874 1639002051 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639002052 active pocket/dimerization site; other site 1639002053 active site 1639002054 phosphorylation site [posttranslational modification] 1639002055 PRD domain; Region: PRD; pfam00874 1639002056 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1639002057 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1639002058 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1639002059 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1639002060 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1639002061 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1639002062 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1639002063 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1639002064 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1639002065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1639002066 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1639002067 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1639002068 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1639002069 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1639002070 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1639002071 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1639002072 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1639002073 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1639002074 NAD binding site [chemical binding]; other site 1639002075 substrate binding site [chemical binding]; other site 1639002076 putative active site [active] 1639002077 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1639002078 EamA-like transporter family; Region: EamA; pfam00892 1639002079 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1639002080 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1639002081 MarR family; Region: MarR_2; pfam12802 1639002082 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1639002083 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 1639002084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1639002085 PAS domain; Region: PAS_9; pfam13426 1639002086 putative active site [active] 1639002087 heme pocket [chemical binding]; other site 1639002088 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1639002089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1639002090 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639002091 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639002092 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639002093 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639002094 LRR adjacent; Region: LRR_adjacent; pfam08191 1639002095 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1639002096 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1639002097 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1639002098 synthetase active site [active] 1639002099 NTP binding site [chemical binding]; other site 1639002100 metal binding site [ion binding]; metal-binding site 1639002101 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1639002102 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1639002103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639002104 non-specific DNA binding site [nucleotide binding]; other site 1639002105 salt bridge; other site 1639002106 sequence-specific DNA binding site [nucleotide binding]; other site 1639002107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002108 Walker A/P-loop; other site 1639002109 ATP binding site [chemical binding]; other site 1639002110 ABC transporter; Region: ABC_tran; pfam00005 1639002111 Q-loop/lid; other site 1639002112 ABC transporter signature motif; other site 1639002113 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1639002114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002115 H-loop/switch region; other site 1639002116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002117 putative PBP binding loops; other site 1639002118 ABC-ATPase subunit interface; other site 1639002119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639002120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639002121 ABC-ATPase subunit interface; other site 1639002122 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1639002123 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1639002124 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1639002125 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1639002126 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1639002127 active site 1639002128 zinc binding site [ion binding]; other site 1639002129 Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012 1639002130 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1639002131 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639002132 Zn2+ binding site [ion binding]; other site 1639002133 Mg2+ binding site [ion binding]; other site 1639002134 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639002135 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639002136 nucleotide binding site [chemical binding]; other site 1639002137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639002138 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1639002139 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1639002140 FMN binding site [chemical binding]; other site 1639002141 substrate binding site [chemical binding]; other site 1639002142 putative catalytic residue [active] 1639002143 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639002144 MarR family; Region: MarR_2; pfam12802 1639002145 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1639002146 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639002147 Coenzyme A binding pocket [chemical binding]; other site 1639002148 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639002149 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639002150 active site 1639002151 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1639002152 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002153 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639002155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639002156 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002157 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1639002158 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002159 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002160 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002161 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1639002162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1639002163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639002164 Coenzyme A binding pocket [chemical binding]; other site 1639002165 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1639002166 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639002167 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639002168 DNA binding residues [nucleotide binding] 1639002169 putative dimer interface [polypeptide binding]; other site 1639002170 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639002171 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639002172 active site 1639002173 catalytic tetrad [active] 1639002174 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1639002175 homodimer interface [polypeptide binding]; other site 1639002176 catalytic residues [active] 1639002177 NAD binding site [chemical binding]; other site 1639002178 substrate binding pocket [chemical binding]; other site 1639002179 flexible flap; other site 1639002180 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1639002181 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1639002182 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1639002183 PhoU domain; Region: PhoU; pfam01895 1639002184 PhoU domain; Region: PhoU; pfam01895 1639002185 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1639002186 Homeodomain-like domain; Region: HTH_23; cl17451 1639002187 HTH-like domain; Region: HTH_21; pfam13276 1639002188 Integrase core domain; Region: rve; pfam00665 1639002189 Integrase core domain; Region: rve_3; cl15866 1639002190 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674 1639002191 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1639002192 dimer interface [polypeptide binding]; other site 1639002193 PYR/PP interface [polypeptide binding]; other site 1639002194 TPP binding site [chemical binding]; other site 1639002195 substrate binding site [chemical binding]; other site 1639002196 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1639002197 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1639002198 Domain of unknown function; Region: EKR; smart00890 1639002199 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1639002200 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1639002201 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1639002202 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 1639002203 Predicted permeases [General function prediction only]; Region: COG0679 1639002204 Helix-turn-helix domain; Region: HTH_28; pfam13518 1639002205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639002206 non-specific DNA binding site [nucleotide binding]; other site 1639002207 salt bridge; other site 1639002208 sequence-specific DNA binding site [nucleotide binding]; other site 1639002209 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639002210 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639002211 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639002212 Predicted membrane protein [Function unknown]; Region: COG3223 1639002213 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639002214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002215 Walker A/P-loop; other site 1639002216 ATP binding site [chemical binding]; other site 1639002217 ABC transporter; Region: ABC_tran; pfam00005 1639002218 Q-loop/lid; other site 1639002219 ABC transporter signature motif; other site 1639002220 Walker B; other site 1639002221 D-loop; other site 1639002222 H-loop/switch region; other site 1639002223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639002224 putative substrate translocation pore; other site 1639002225 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1639002226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639002227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639002228 putative substrate translocation pore; other site 1639002229 MarR family; Region: MarR_2; cl17246 1639002230 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002231 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639002232 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002233 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1639002234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002235 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1639002236 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1639002237 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1639002238 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1639002239 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1639002240 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1639002241 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 1639002242 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1639002243 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1639002244 substrate binding site [chemical binding]; other site 1639002245 zinc-binding site [ion binding]; other site 1639002246 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1639002247 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1639002248 GIY-YIG motif/motif A; other site 1639002249 active site 1639002250 catalytic site [active] 1639002251 putative DNA binding site [nucleotide binding]; other site 1639002252 metal binding site [ion binding]; metal-binding site 1639002253 UvrB/uvrC motif; Region: UVR; pfam02151 1639002254 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1639002255 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1639002256 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1639002257 substrate binding pocket [chemical binding]; other site 1639002258 membrane-bound complex binding site; other site 1639002259 hinge residues; other site 1639002260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639002261 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002262 ABC-ATPase subunit interface; other site 1639002263 putative PBP binding loops; other site 1639002264 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639002265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002266 Walker A/P-loop; other site 1639002267 ATP binding site [chemical binding]; other site 1639002268 Q-loop/lid; other site 1639002269 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639002270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002271 ABC transporter signature motif; other site 1639002272 Walker B; other site 1639002273 D-loop; other site 1639002274 H-loop/switch region; other site 1639002275 amidase; Provisional; Region: PRK11910 1639002276 Amidase; Region: Amidase; cl11426 1639002277 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1639002278 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1639002279 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1639002280 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1639002281 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1639002282 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1639002283 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1639002284 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1639002285 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 1639002286 Esterase/lipase [General function prediction only]; Region: COG1647 1639002287 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639002288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639002289 DNA binding site [nucleotide binding] 1639002290 domain linker motif; other site 1639002291 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 1639002292 putative dimerization interface [polypeptide binding]; other site 1639002293 putative ligand binding site [chemical binding]; other site 1639002294 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639002295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639002296 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1639002297 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1639002298 ABC-ATPase subunit interface; other site 1639002299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639002300 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639002301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002302 ABC-ATPase subunit interface; other site 1639002303 putative PBP binding loops; other site 1639002304 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1639002305 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1639002306 active site 1639002307 catalytic site [active] 1639002308 Protein of unknown function (DUF1861); Region: DUF1861; pfam08950 1639002309 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 1639002310 active site 1639002311 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1639002312 active site 1639002313 substrate binding site [chemical binding]; other site 1639002314 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1639002315 metal binding site [ion binding]; metal-binding site 1639002316 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1639002317 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1639002318 ATP binding site [chemical binding]; other site 1639002319 Mg++ binding site [ion binding]; other site 1639002320 motif III; other site 1639002321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639002322 nucleotide binding region [chemical binding]; other site 1639002323 ATP-binding site [chemical binding]; other site 1639002324 Predicted membrane protein [Function unknown]; Region: COG4708 1639002325 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1639002326 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; pfam10078 1639002327 Predicted transcriptional regulators [Transcription]; Region: COG1733 1639002328 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1639002329 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1639002330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639002331 putative substrate translocation pore; other site 1639002332 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639002333 PRD domain; Region: PRD; pfam00874 1639002334 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639002335 active site 1639002336 P-loop; other site 1639002337 phosphorylation site [posttranslational modification] 1639002338 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639002339 active site 1639002340 phosphorylation site [posttranslational modification] 1639002341 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639002342 methionine cluster; other site 1639002343 active site 1639002344 phosphorylation site [posttranslational modification] 1639002345 metal binding site [ion binding]; metal-binding site 1639002346 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639002347 active site 1639002348 P-loop; other site 1639002349 phosphorylation site [posttranslational modification] 1639002350 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639002351 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639002352 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1639002353 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1639002354 active site 1639002355 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 1639002356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639002357 catalytic tetrad [active] 1639002358 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 1639002359 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1639002360 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639002361 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1639002362 Bacterial PH domain; Region: DUF304; pfam03703 1639002363 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1639002364 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1639002365 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1639002366 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1639002367 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1639002368 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1639002369 PemK-like protein; Region: PemK; pfam02452 1639002370 Rsbr N terminal; Region: Rsbr_N; pfam08678 1639002371 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1639002372 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1639002373 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1639002374 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1639002375 ATP binding site [chemical binding]; other site 1639002376 Mg2+ binding site [ion binding]; other site 1639002377 G-X-G motif; other site 1639002378 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1639002379 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1639002380 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1639002381 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1639002382 anti sigma factor interaction site; other site 1639002383 regulatory phosphorylation site [posttranslational modification]; other site 1639002384 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1639002385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639002386 ATP binding site [chemical binding]; other site 1639002387 Mg2+ binding site [ion binding]; other site 1639002388 G-X-G motif; other site 1639002389 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1639002390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1639002391 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1639002392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1639002393 DNA binding residues [nucleotide binding] 1639002394 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 1639002395 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1639002396 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1639002397 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1639002398 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1639002399 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1639002400 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1639002401 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1639002402 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1639002403 RNA binding site [nucleotide binding]; other site 1639002404 hypothetical protein; Provisional; Region: PRK04351 1639002405 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1639002406 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1639002407 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639002408 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1639002409 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639002410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639002411 DNA-binding site [nucleotide binding]; DNA binding site 1639002412 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639002413 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1639002414 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1639002415 Predicted protein tyrosine phosphatase [General function prediction only]; Region: COG5350 1639002416 glutathione reductase; Validated; Region: PRK06116 1639002417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639002418 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1639002419 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1639002420 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1639002421 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1639002422 Predicted transcriptional regulators [Transcription]; Region: COG1725 1639002423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639002424 DNA-binding site [nucleotide binding]; DNA binding site 1639002425 Predicted membrane protein [General function prediction only]; Region: COG4194 1639002426 Predicted membrane protein [General function prediction only]; Region: COG4194 1639002427 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1639002428 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1639002429 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1639002430 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1639002431 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1639002432 NAD(P) binding site [chemical binding]; other site 1639002433 catalytic residues [active] 1639002434 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1639002435 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1639002436 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639002437 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639002438 methionine cluster; other site 1639002439 active site 1639002440 phosphorylation site [posttranslational modification] 1639002441 metal binding site [ion binding]; metal-binding site 1639002442 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1639002443 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639002444 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639002445 PRD domain; Region: PRD; pfam00874 1639002446 PRD domain; Region: PRD; pfam00874 1639002447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639002448 active site 1639002449 phosphorylation site [posttranslational modification] 1639002450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639002451 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1639002452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002453 Walker A/P-loop; other site 1639002454 ATP binding site [chemical binding]; other site 1639002455 Q-loop/lid; other site 1639002456 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1639002457 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639002458 Predicted permeases [General function prediction only]; Region: COG0701 1639002459 Predicted membrane protein [Function unknown]; Region: COG3689 1639002460 pantothenate kinase; Provisional; Region: PRK05439 1639002461 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1639002462 ATP-binding site [chemical binding]; other site 1639002463 CoA-binding site [chemical binding]; other site 1639002464 Mg2+-binding site [ion binding]; other site 1639002465 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1639002466 Walker A/P-loop; other site 1639002467 ATP binding site [chemical binding]; other site 1639002468 ABC transporter; Region: ABC_tran; pfam00005 1639002469 Q-loop/lid; other site 1639002470 ABC transporter signature motif; other site 1639002471 Walker B; other site 1639002472 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1639002473 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1639002474 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639002475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639002476 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1639002477 Domain of unknown function (DUF373); Region: DUF373; cl12079 1639002478 Sulfatase; Region: Sulfatase; pfam00884 1639002479 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1639002480 active site 1639002481 DNA binding site [nucleotide binding] 1639002482 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1639002483 active site 1639002484 catalytic site [active] 1639002485 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1639002486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1639002487 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1639002488 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1639002489 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1639002490 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1639002491 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1639002492 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1639002493 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1639002494 Ligand binding site; other site 1639002495 Putative Catalytic site; other site 1639002496 DXD motif; other site 1639002497 epoxyqueuosine reductase; Region: TIGR00276 1639002498 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1639002499 A new structural DNA glycosylase; Region: AlkD_like; cl11434 1639002500 active site 1639002501 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1639002502 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1639002503 dimer interface [polypeptide binding]; other site 1639002504 FMN binding site [chemical binding]; other site 1639002505 NADPH bind site [chemical binding]; other site 1639002506 HSP90 family protein; Provisional; Region: PRK14083 1639002507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639002508 ATP binding site [chemical binding]; other site 1639002509 Mg2+ binding site [ion binding]; other site 1639002510 G-X-G motif; other site 1639002511 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1639002512 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1639002513 dimerization interface [polypeptide binding]; other site 1639002514 DPS ferroxidase diiron center [ion binding]; other site 1639002515 ion pore; other site 1639002516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1639002517 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1639002518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639002519 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1639002520 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1639002521 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1639002522 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1639002523 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1639002524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639002525 putative substrate translocation pore; other site 1639002526 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1639002527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639002528 DNA-binding site [nucleotide binding]; DNA binding site 1639002529 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1639002530 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1639002531 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1639002532 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1639002533 Uncharacterized protein with an alpha/beta hydrolase fold [General function prediction only]; Region: COG4814 1639002534 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 1639002535 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1639002536 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1639002537 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1639002538 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1639002539 active site 1639002540 dimer interface [polypeptide binding]; other site 1639002541 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1639002542 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1639002543 active site 1639002544 trimer interface [polypeptide binding]; other site 1639002545 allosteric site; other site 1639002546 active site lid [active] 1639002547 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1639002548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639002549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639002550 DNA-binding site [nucleotide binding]; DNA binding site 1639002551 UTRA domain; Region: UTRA; pfam07702 1639002552 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1639002553 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1639002554 Mg++ binding site [ion binding]; other site 1639002555 putative catalytic motif [active] 1639002556 substrate binding site [chemical binding]; other site 1639002557 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1639002558 Peptidase family U32; Region: Peptidase_U32; pfam01136 1639002559 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1639002560 Peptidase family U32; Region: Peptidase_U32; pfam01136 1639002561 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1639002562 heat shock protein HtpX; Provisional; Region: PRK04897 1639002563 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1639002564 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 1639002565 catalytic residues [active] 1639002566 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1639002567 putative active site [active] 1639002568 putative metal binding residues [ion binding]; other site 1639002569 signature motif; other site 1639002570 putative triphosphate binding site [ion binding]; other site 1639002571 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639002572 TPR motif; other site 1639002573 binding surface 1639002574 TPR repeat; Region: TPR_11; pfam13414 1639002575 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1639002576 synthetase active site [active] 1639002577 NTP binding site [chemical binding]; other site 1639002578 metal binding site [ion binding]; metal-binding site 1639002579 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1639002580 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1639002581 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1639002582 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1639002583 active site 1639002584 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1639002585 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1639002586 NAD binding site [chemical binding]; other site 1639002587 homotetramer interface [polypeptide binding]; other site 1639002588 homodimer interface [polypeptide binding]; other site 1639002589 substrate binding site [chemical binding]; other site 1639002590 active site 1639002591 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1639002592 DltD N-terminal region; Region: DltD_N; pfam04915 1639002593 DltD central region; Region: DltD_M; pfam04918 1639002594 DltD C-terminal region; Region: DltD_C; pfam04914 1639002595 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1639002596 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1639002597 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1639002598 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1639002599 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1639002600 acyl-activating enzyme (AAE) consensus motif; other site 1639002601 AMP binding site [chemical binding]; other site 1639002602 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1639002603 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1639002604 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639002605 active site 1639002606 dimer interface [polypeptide binding]; other site 1639002607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639002608 Coenzyme A binding pocket [chemical binding]; other site 1639002609 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1639002610 Putative esterase; Region: Esterase; pfam00756 1639002611 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1639002612 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1639002613 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1639002614 substrate-cofactor binding pocket; other site 1639002615 catalytic residue [active] 1639002616 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1639002617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002618 Walker A/P-loop; other site 1639002619 ATP binding site [chemical binding]; other site 1639002620 Q-loop/lid; other site 1639002621 ABC transporter signature motif; other site 1639002622 Walker B; other site 1639002623 D-loop; other site 1639002624 H-loop/switch region; other site 1639002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639002626 putative substrate translocation pore; other site 1639002627 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1639002628 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1639002629 putative oligomer interface [polypeptide binding]; other site 1639002630 putative active site [active] 1639002631 metal binding site [ion binding]; metal-binding site 1639002632 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1639002633 catalytic residues [active] 1639002634 dimer interface [polypeptide binding]; other site 1639002635 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1639002636 LytTr DNA-binding domain; Region: LytTR; pfam04397 1639002637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639002638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002639 Walker A/P-loop; other site 1639002640 ATP binding site [chemical binding]; other site 1639002641 Q-loop/lid; other site 1639002642 ABC transporter signature motif; other site 1639002643 Walker B; other site 1639002644 D-loop; other site 1639002645 H-loop/switch region; other site 1639002646 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1639002647 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1639002648 G1 box; other site 1639002649 putative GEF interaction site [polypeptide binding]; other site 1639002650 GTP/Mg2+ binding site [chemical binding]; other site 1639002651 Switch I region; other site 1639002652 G2 box; other site 1639002653 G3 box; other site 1639002654 Switch II region; other site 1639002655 G4 box; other site 1639002656 G5 box; other site 1639002657 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1639002658 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639002659 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639002660 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639002661 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639002662 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639002663 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1639002664 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1639002665 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1639002666 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1639002667 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1639002668 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1639002669 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1639002670 DNA binding site [nucleotide binding] 1639002671 active site 1639002672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639002673 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1639002674 Walker A motif; other site 1639002675 ATP binding site [chemical binding]; other site 1639002676 Walker B motif; other site 1639002677 arginine finger; other site 1639002678 UvrB/uvrC motif; Region: UVR; pfam02151 1639002679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639002680 Walker A motif; other site 1639002681 ATP binding site [chemical binding]; other site 1639002682 Walker B motif; other site 1639002683 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1639002684 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1639002685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1639002686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4873 1639002687 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1639002688 dimerization domain swap beta strand [polypeptide binding]; other site 1639002689 regulatory protein interface [polypeptide binding]; other site 1639002690 active site 1639002691 regulatory phosphorylation site [posttranslational modification]; other site 1639002692 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1639002693 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1639002694 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1639002695 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1639002696 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1639002697 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1639002698 putative active site [active] 1639002699 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1639002700 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1639002701 aminotransferase A; Validated; Region: PRK07683 1639002702 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639002703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639002704 homodimer interface [polypeptide binding]; other site 1639002705 catalytic residue [active] 1639002706 FOG: CBS domain [General function prediction only]; Region: COG0517 1639002707 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1639002708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639002709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639002710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1639002711 dimerization interface [polypeptide binding]; other site 1639002712 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1639002713 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1639002714 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1639002715 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1639002716 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1639002717 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1639002718 metal binding site [ion binding]; metal-binding site 1639002719 putative dimer interface [polypeptide binding]; other site 1639002720 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1639002721 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1639002722 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1639002723 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1639002724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639002725 Walker A/P-loop; other site 1639002726 ATP binding site [chemical binding]; other site 1639002727 Q-loop/lid; other site 1639002728 ABC transporter signature motif; other site 1639002729 Walker B; other site 1639002730 D-loop; other site 1639002731 H-loop/switch region; other site 1639002732 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1639002733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002734 dimer interface [polypeptide binding]; other site 1639002735 conserved gate region; other site 1639002736 putative PBP binding loops; other site 1639002737 ABC-ATPase subunit interface; other site 1639002738 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1639002739 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1639002740 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1639002741 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1639002742 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1639002743 HPr interaction site; other site 1639002744 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639002745 active site 1639002746 phosphorylation site [posttranslational modification] 1639002747 CutC family; Region: CutC; cl01218 1639002748 S1 domain; Region: S1_2; pfam13509 1639002749 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1639002750 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1639002751 RNA binding site [nucleotide binding]; other site 1639002752 Predicted membrane protein [Function unknown]; Region: COG4758 1639002753 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1639002754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1639002755 Histidine kinase; Region: HisKA_3; pfam07730 1639002756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639002757 ATP binding site [chemical binding]; other site 1639002758 Mg2+ binding site [ion binding]; other site 1639002759 G-X-G motif; other site 1639002760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1639002761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639002762 active site 1639002763 phosphorylation site [posttranslational modification] 1639002764 intermolecular recognition site; other site 1639002765 dimerization interface [polypeptide binding]; other site 1639002766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1639002767 DNA binding residues [nucleotide binding] 1639002768 dimerization interface [polypeptide binding]; other site 1639002769 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1639002770 TrkA-N domain; Region: TrkA_N; pfam02254 1639002771 TrkA-C domain; Region: TrkA_C; pfam02080 1639002772 Predicted membrane protein [Function unknown]; Region: COG1289 1639002773 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1639002774 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1639002775 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1639002776 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1639002777 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1639002778 hypothetical protein; Provisional; Region: PRK13667 1639002779 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639002780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639002781 active site 1639002782 motif I; other site 1639002783 motif II; other site 1639002784 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639002785 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639002786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639002787 DNA binding site [nucleotide binding] 1639002788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639002789 ligand binding site [chemical binding]; other site 1639002790 dimerization interface [polypeptide binding]; other site 1639002791 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1639002792 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1639002793 trimer interface [polypeptide binding]; other site 1639002794 substrate binding site [chemical binding]; other site 1639002795 Mn binding site [ion binding]; other site 1639002796 transketolase; Reviewed; Region: PRK05899 1639002797 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1639002798 TPP-binding site [chemical binding]; other site 1639002799 dimer interface [polypeptide binding]; other site 1639002800 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1639002801 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1639002802 PYR/PP interface [polypeptide binding]; other site 1639002803 dimer interface [polypeptide binding]; other site 1639002804 TPP binding site [chemical binding]; other site 1639002805 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639002806 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1639002807 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639002808 nucleotide binding site [chemical binding]; other site 1639002809 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1639002810 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639002811 active site turn [active] 1639002812 phosphorylation site [posttranslational modification] 1639002813 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639002814 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1639002815 HPr interaction site; other site 1639002816 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639002817 active site 1639002818 phosphorylation site [posttranslational modification] 1639002819 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1639002820 Protein of unknown function (DUF817); Region: DUF817; cl01520 1639002821 Protein of unknown function (DUF817); Region: DUF817; cl01520 1639002822 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1639002823 GTP binding site; other site 1639002824 ATP-binding cassette domain of the molybdenum transport system; Region: ABC_ModC_molybdenum_transporter; cd03297 1639002825 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1639002826 Walker A/P-loop; other site 1639002827 ATP binding site [chemical binding]; other site 1639002828 Q-loop/lid; other site 1639002829 ABC transporter signature motif; other site 1639002830 Walker B; other site 1639002831 D-loop; other site 1639002832 H-loop/switch region; other site 1639002833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639002834 ABC-ATPase subunit interface; other site 1639002835 putative PBP binding loops; other site 1639002836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639002837 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1639002838 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1639002839 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1639002840 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1639002841 dimer interface [polypeptide binding]; other site 1639002842 putative functional site; other site 1639002843 putative MPT binding site; other site 1639002844 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1639002845 Walker A motif; other site 1639002846 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 1639002847 MoaE homodimer interface [polypeptide binding]; other site 1639002848 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1639002849 MoaD interaction [polypeptide binding]; other site 1639002850 active site residues [active] 1639002851 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1639002852 MoaE interaction surface [polypeptide binding]; other site 1639002853 MoeB interaction surface [polypeptide binding]; other site 1639002854 thiocarboxylated glycine; other site 1639002855 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1639002856 trimer interface [polypeptide binding]; other site 1639002857 dimer interface [polypeptide binding]; other site 1639002858 putative active site [active] 1639002859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1639002860 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1639002861 FeS/SAM binding site; other site 1639002862 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1639002863 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1639002864 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1639002865 MPT binding site; other site 1639002866 trimer interface [polypeptide binding]; other site 1639002867 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1639002868 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1639002869 ATP binding site [chemical binding]; other site 1639002870 substrate interface [chemical binding]; other site 1639002871 Flavin Reductases; Region: FlaRed; cl00801 1639002872 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1639002873 active site 1639002874 catalytic residues [active] 1639002875 metal binding site [ion binding]; metal-binding site 1639002876 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1639002877 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1639002878 TPP-binding site [chemical binding]; other site 1639002879 tetramer interface [polypeptide binding]; other site 1639002880 heterodimer interface [polypeptide binding]; other site 1639002881 phosphorylation loop region [posttranslational modification] 1639002882 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1639002883 alpha subunit interface [polypeptide binding]; other site 1639002884 TPP binding site [chemical binding]; other site 1639002885 heterodimer interface [polypeptide binding]; other site 1639002886 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639002887 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1639002888 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1639002889 E3 interaction surface; other site 1639002890 lipoyl attachment site [posttranslational modification]; other site 1639002891 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1639002892 E3 interaction surface; other site 1639002893 lipoyl attachment site [posttranslational modification]; other site 1639002894 e3 binding domain; Region: E3_binding; pfam02817 1639002895 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1639002896 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1639002897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1639002898 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639002899 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1639002900 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 1639002901 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1639002902 NAD(P) binding site [chemical binding]; other site 1639002903 LDH/MDH dimer interface [polypeptide binding]; other site 1639002904 substrate binding site [chemical binding]; other site 1639002905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4476 1639002906 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1639002907 Thioredoxin; Region: Thioredoxin_4; pfam13462 1639002908 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639002909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639002910 active site 1639002911 phosphorylation site [posttranslational modification] 1639002912 intermolecular recognition site; other site 1639002913 dimerization interface [polypeptide binding]; other site 1639002914 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639002915 DNA binding site [nucleotide binding] 1639002916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1639002917 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639002918 dimerization interface [polypeptide binding]; other site 1639002919 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639002920 dimer interface [polypeptide binding]; other site 1639002921 phosphorylation site [posttranslational modification] 1639002922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639002923 ATP binding site [chemical binding]; other site 1639002924 Mg2+ binding site [ion binding]; other site 1639002925 G-X-G motif; other site 1639002926 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639002927 FtsX-like permease family; Region: FtsX; pfam02687 1639002928 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639002929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639002930 Walker A/P-loop; other site 1639002931 ATP binding site [chemical binding]; other site 1639002932 Q-loop/lid; other site 1639002933 ABC transporter signature motif; other site 1639002934 Walker B; other site 1639002935 D-loop; other site 1639002936 H-loop/switch region; other site 1639002937 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1639002938 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1639002939 Cl binding site [ion binding]; other site 1639002940 oligomer interface [polypeptide binding]; other site 1639002941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1639002942 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1639002943 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1639002944 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1639002945 active site 1639002946 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1639002947 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1639002948 G1 box; other site 1639002949 putative GEF interaction site [polypeptide binding]; other site 1639002950 GTP/Mg2+ binding site [chemical binding]; other site 1639002951 Switch I region; other site 1639002952 G2 box; other site 1639002953 G3 box; other site 1639002954 Switch II region; other site 1639002955 G4 box; other site 1639002956 G5 box; other site 1639002957 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1639002958 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1639002959 hypothetical protein; Provisional; Region: PRK13666 1639002960 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1639002961 pyruvate carboxylase; Reviewed; Region: PRK12999 1639002962 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1639002963 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1639002964 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1639002965 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1639002966 active site 1639002967 catalytic residues [active] 1639002968 metal binding site [ion binding]; metal-binding site 1639002969 homodimer binding site [polypeptide binding]; other site 1639002970 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1639002971 carboxyltransferase (CT) interaction site; other site 1639002972 biotinylation site [posttranslational modification]; other site 1639002973 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1639002974 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1639002975 putative binding site residues; other site 1639002976 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1639002977 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1639002978 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1639002979 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1639002980 Walker A/P-loop; other site 1639002981 ATP binding site [chemical binding]; other site 1639002982 Q-loop/lid; other site 1639002983 ABC transporter signature motif; other site 1639002984 Walker B; other site 1639002985 D-loop; other site 1639002986 H-loop/switch region; other site 1639002987 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1639002988 SH3-like domain; Region: SH3_8; pfam13457 1639002989 SH3-like domain; Region: SH3_8; pfam13457 1639002990 SH3-like domain; Region: SH3_8; pfam13457 1639002991 SH3-like domain; Region: SH3_8; pfam13457 1639002992 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1639002993 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1639002994 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1639002995 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1639002996 active site 1639002997 tetramer interface; other site 1639002998 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1639002999 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 1639003000 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1639003001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1639003002 active site 1639003003 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1639003004 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1639003005 substrate binding site; other site 1639003006 tetramer interface; other site 1639003007 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1639003008 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1639003009 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1639003010 NAD binding site [chemical binding]; other site 1639003011 substrate binding site [chemical binding]; other site 1639003012 homodimer interface [polypeptide binding]; other site 1639003013 active site 1639003014 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1639003015 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1639003016 NADP binding site [chemical binding]; other site 1639003017 active site 1639003018 putative substrate binding site [chemical binding]; other site 1639003019 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1639003020 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1639003021 substrate binding site; other site 1639003022 dimer interface; other site 1639003023 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 1639003024 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639003025 putative NAD(P) binding site [chemical binding]; other site 1639003026 putative catalytic Zn binding site [ion binding]; other site 1639003027 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1639003028 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 1639003029 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1639003030 active site 1639003031 putative glycosyl transferase; Provisional; Region: PRK10073 1639003032 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1639003033 active site 1639003034 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1639003035 active site 1639003036 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1639003037 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1639003038 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1639003039 active site 1639003040 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1639003041 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1639003042 homodimer interface [polypeptide binding]; other site 1639003043 NAD binding pocket [chemical binding]; other site 1639003044 ATP binding pocket [chemical binding]; other site 1639003045 Mg binding site [ion binding]; other site 1639003046 active-site loop [active] 1639003047 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1639003048 Dimerization subdomain; other site 1639003049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1639003050 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1639003051 MepB protein; Region: MepB; cl01985 1639003052 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1639003053 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1639003054 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639003055 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1639003056 DNA binding residues [nucleotide binding] 1639003057 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1639003058 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639003059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639003060 Walker A/P-loop; other site 1639003061 ATP binding site [chemical binding]; other site 1639003062 Q-loop/lid; other site 1639003063 ABC transporter signature motif; other site 1639003064 Walker B; other site 1639003065 D-loop; other site 1639003066 H-loop/switch region; other site 1639003067 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639003068 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639003069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639003070 Walker A/P-loop; other site 1639003071 ATP binding site [chemical binding]; other site 1639003072 Q-loop/lid; other site 1639003073 ABC transporter signature motif; other site 1639003074 Walker B; other site 1639003075 D-loop; other site 1639003076 H-loop/switch region; other site 1639003077 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1639003078 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639003079 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639003080 DNA binding residues [nucleotide binding] 1639003081 putative dimer interface [polypeptide binding]; other site 1639003082 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639003083 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1639003084 LRR adjacent; Region: LRR_adjacent; pfam08191 1639003085 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639003086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 1639003087 Clp protease; Region: CLP_protease; pfam00574 1639003088 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1639003089 oligomer interface [polypeptide binding]; other site 1639003090 active site residues [active] 1639003091 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1639003092 dimer interface [polypeptide binding]; other site 1639003093 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639003094 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1639003095 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1639003096 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1639003097 SLBB domain; Region: SLBB; pfam10531 1639003098 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1639003099 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 1639003100 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003101 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1639003102 putative hexamer interface [polypeptide binding]; other site 1639003103 putative hexagonal pore; other site 1639003104 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1639003105 putative hexamer interface [polypeptide binding]; other site 1639003106 putative hexagonal pore; other site 1639003107 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1639003108 putative hexamer interface [polypeptide binding]; other site 1639003109 putative hexagonal pore; other site 1639003110 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1639003111 G1 box; other site 1639003112 GTP/Mg2+ binding site [chemical binding]; other site 1639003113 G2 box; other site 1639003114 Switch I region; other site 1639003115 G3 box; other site 1639003116 Switch II region; other site 1639003117 G4 box; other site 1639003118 G5 box; other site 1639003119 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1639003120 homotrimer interface [polypeptide binding]; other site 1639003121 Walker A motif; other site 1639003122 GTP binding site [chemical binding]; other site 1639003123 Walker B motif; other site 1639003124 Cobalamin-5-phosphate synthase [Coenzyme metabolism]; Region: CobS; COG0368 1639003125 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639003126 catalytic core [active] 1639003127 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1639003128 Sensory domain found in PocR; Region: PocR; pfam10114 1639003129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639003130 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639003131 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639003132 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003133 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1639003134 Hexamer interface [polypeptide binding]; other site 1639003135 Hexagonal pore residue; other site 1639003136 propanediol utilization protein PduB; Provisional; Region: PRK15415 1639003137 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 1639003138 putative hexamer interface [polypeptide binding]; other site 1639003139 putative hexagonal pore; other site 1639003140 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 1639003141 putative hexamer interface [polypeptide binding]; other site 1639003142 putative hexagonal pore; other site 1639003143 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 1639003144 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 1639003145 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 1639003146 alpha-beta subunit interface [polypeptide binding]; other site 1639003147 alpha-gamma subunit interface [polypeptide binding]; other site 1639003148 active site 1639003149 substrate and K+ binding site; other site 1639003150 K+ binding site [ion binding]; other site 1639003151 cobalamin binding site [chemical binding]; other site 1639003152 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 1639003153 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 1639003154 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1639003155 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 1639003156 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 1639003157 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003158 1,2-propanediol utilization protein K (PduK), Bacterial Micro-Compartment (BMC) domain repeat 1l; Region: BMC_PduK; cd07056 1639003159 putative hexamer interface [polypeptide binding]; other site 1639003160 putative hexagonal pore; other site 1639003161 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003162 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1639003163 Hexamer interface [polypeptide binding]; other site 1639003164 Hexagonal pore residue; other site 1639003165 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 1639003166 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1639003167 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1639003168 Cell division protein FtsA; Region: FtsA; cl17206 1639003169 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1639003170 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 1639003171 carboxy-terminal protease; Provisional; Region: PRK11186 1639003172 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 1639003173 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1639003174 putative catalytic cysteine [active] 1639003175 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1639003176 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 1639003177 putative active site [active] 1639003178 metal binding site [ion binding]; metal-binding site 1639003179 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1639003180 amphipathic channel; other site 1639003181 Asn-Pro-Ala signature motifs; other site 1639003182 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1639003183 amphipathic channel; other site 1639003184 Asn-Pro-Ala signature motifs; other site 1639003185 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1639003186 propionate/acetate kinase; Provisional; Region: PRK12379 1639003187 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 1639003188 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639003190 homodimer interface [polypeptide binding]; other site 1639003191 catalytic residue [active] 1639003192 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1639003193 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1639003194 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1639003195 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1639003196 metal binding site [ion binding]; metal-binding site 1639003197 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1639003198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639003199 active site 1639003200 phosphorylation site [posttranslational modification] 1639003201 intermolecular recognition site; other site 1639003202 dimerization interface [polypeptide binding]; other site 1639003203 ANTAR domain; Region: ANTAR; pfam03861 1639003204 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1639003205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1639003206 Histidine kinase; Region: HisKA_2; pfam07568 1639003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639003208 ATP binding site [chemical binding]; other site 1639003209 Mg2+ binding site [ion binding]; other site 1639003210 G-X-G motif; other site 1639003211 Ethanolamine utilization protein, possible chaperonin protecting lyase from inhibition [Amino acid transport and metabolism]; Region: EutA; COG4819 1639003212 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1639003213 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1639003214 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1639003215 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1639003216 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1639003217 putative hexamer interface [polypeptide binding]; other site 1639003218 putative hexagonal pore; other site 1639003219 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1639003220 putative hexamer interface [polypeptide binding]; other site 1639003221 putative hexagonal pore; other site 1639003222 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003223 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1639003224 Hexamer interface [polypeptide binding]; other site 1639003225 Hexagonal pore residue; other site 1639003226 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1639003227 putative catalytic cysteine [active] 1639003228 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1639003229 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1639003230 Hexamer interface [polypeptide binding]; other site 1639003231 Putative hexagonal pore residue; other site 1639003232 Ethanolamine utilization cobalamin adenosyltransferase [Amino acid transport and metabolism]; Region: EutT; COG4812 1639003233 Propanediol utilization protein [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduL; COG4869 1639003234 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1639003235 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1639003236 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 1639003237 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1639003238 Hexamer/Pentamer interface [polypeptide binding]; other site 1639003239 central pore; other site 1639003240 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 1639003241 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 1639003242 putative hexamer interface [polypeptide binding]; other site 1639003243 putative hexagonal pore; other site 1639003244 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 1639003245 putative hexamer interface [polypeptide binding]; other site 1639003246 putative hexagonal pore; other site 1639003247 Ethanolamine utilisation protein, EutH; Region: EutH; pfam04346 1639003248 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1639003249 Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249 1639003250 hypothetical protein; Region: PHA01818 1639003251 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639003252 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639003253 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639003254 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1639003255 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1639003256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639003257 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1639003258 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1639003259 catalytic triad [active] 1639003260 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1639003261 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1639003262 CobD/Cbib protein; Region: CobD_Cbib; cl00561 1639003263 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 1639003264 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1639003265 Cobalamin biosynthesis protein CbiD [Coenzyme metabolism]; Region: CbiD; COG1903 1639003266 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1639003267 active site 1639003268 putative homodimer interface [polypeptide binding]; other site 1639003269 SAM binding site [chemical binding]; other site 1639003270 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 1639003271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639003272 S-adenosylmethionine binding site [chemical binding]; other site 1639003273 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1639003274 active site 1639003275 homodimer interface [polypeptide binding]; other site 1639003276 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1639003277 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1639003278 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1639003279 SAM binding site [chemical binding]; other site 1639003280 active site 1639003281 homodimer interface [polypeptide binding]; other site 1639003282 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1639003283 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1639003284 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1639003285 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1639003286 active site 1639003287 SAM binding site [chemical binding]; other site 1639003288 homodimer interface [polypeptide binding]; other site 1639003289 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1639003290 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1639003291 active site 1639003292 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1639003293 active site 1639003294 C-terminal domain interface [polypeptide binding]; other site 1639003295 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1639003296 active site 1639003297 SAM binding site [chemical binding]; other site 1639003298 homodimer interface [polypeptide binding]; other site 1639003299 cobalt transport protein CbiM; Validated; Region: PRK08319 1639003300 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1639003301 ABC-type cobalt transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiN; COG1930 1639003302 cobalt transport protein CbiQ; Provisional; Region: PRK15485 1639003303 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 1639003304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1639003305 Walker A/P-loop; other site 1639003306 ATP binding site [chemical binding]; other site 1639003307 Q-loop/lid; other site 1639003308 ABC transporter signature motif; other site 1639003309 Walker B; other site 1639003310 D-loop; other site 1639003311 H-loop/switch region; other site 1639003312 cobyric acid synthase; Provisional; Region: PRK00784 1639003313 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639003314 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1639003315 catalytic triad [active] 1639003316 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1639003317 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1639003318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1639003319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1639003320 topology modulation protein; Provisional; Region: PRK07261 1639003321 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1639003322 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1639003323 SH3-like domain; Region: SH3_8; pfam13457 1639003324 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1639003325 SH3-like domain; Region: SH3_8; pfam13457 1639003326 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1639003327 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639003328 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639003329 metal binding site [ion binding]; metal-binding site 1639003330 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639003331 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1639003332 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1639003333 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1639003334 Predicted transcriptional regulators [Transcription]; Region: COG1733 1639003335 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1639003336 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1639003337 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1639003338 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1639003339 dimer interface [polypeptide binding]; other site 1639003340 motif 1; other site 1639003341 active site 1639003342 motif 2; other site 1639003343 motif 3; other site 1639003344 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1639003345 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1639003346 putative tRNA-binding site [nucleotide binding]; other site 1639003347 B3/4 domain; Region: B3_4; pfam03483 1639003348 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1639003349 tRNA synthetase B5 domain; Region: B5; smart00874 1639003350 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1639003351 dimer interface [polypeptide binding]; other site 1639003352 motif 1; other site 1639003353 motif 3; other site 1639003354 motif 2; other site 1639003355 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1639003356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639003357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639003358 Walker A/P-loop; other site 1639003359 ATP binding site [chemical binding]; other site 1639003360 Q-loop/lid; other site 1639003361 ABC transporter signature motif; other site 1639003362 Walker B; other site 1639003363 D-loop; other site 1639003364 H-loop/switch region; other site 1639003365 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639003366 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1639003367 FtsX-like permease family; Region: FtsX; pfam02687 1639003368 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1639003369 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639003370 FtsX-like permease family; Region: FtsX; pfam02687 1639003371 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1639003372 MarR family; Region: MarR_2; pfam12802 1639003373 MMPL family; Region: MMPL; pfam03176 1639003374 Predicted membrane protein [Function unknown]; Region: COG1511 1639003375 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1639003376 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1639003377 ligand binding site [chemical binding]; other site 1639003378 active site 1639003379 UGI interface [polypeptide binding]; other site 1639003380 catalytic site [active] 1639003381 ribonuclease HIII; Provisional; Region: PRK00996 1639003382 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1639003383 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1639003384 RNA/DNA hybrid binding site [nucleotide binding]; other site 1639003385 active site 1639003386 Cell division protein ZapA; Region: ZapA; cl01146 1639003387 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1639003388 Colicin V production protein; Region: Colicin_V; pfam02674 1639003389 hypothetical protein; Provisional; Region: PRK08609 1639003390 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1639003391 active site 1639003392 primer binding site [nucleotide binding]; other site 1639003393 NTP binding site [chemical binding]; other site 1639003394 metal binding triad [ion binding]; metal-binding site 1639003395 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1639003396 active site 1639003397 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1639003398 MutS domain III; Region: MutS_III; pfam05192 1639003399 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639003400 Walker A/P-loop; other site 1639003401 ATP binding site [chemical binding]; other site 1639003402 Q-loop/lid; other site 1639003403 ABC transporter signature motif; other site 1639003404 Walker B; other site 1639003405 D-loop; other site 1639003406 H-loop/switch region; other site 1639003407 Smr domain; Region: Smr; pfam01713 1639003408 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639003409 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1639003410 catalytic residues [active] 1639003411 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1639003412 GIY-YIG motif/motif A; other site 1639003413 active site 1639003414 catalytic site [active] 1639003415 putative DNA binding site [nucleotide binding]; other site 1639003416 metal binding site [ion binding]; metal-binding site 1639003417 UvrB/uvrC motif; Region: UVR; pfam02151 1639003418 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1639003419 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1639003420 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1639003421 DNA binding site [nucleotide binding] 1639003422 aspartate kinase; Reviewed; Region: PRK06635 1639003423 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1639003424 putative nucleotide binding site [chemical binding]; other site 1639003425 putative catalytic residues [active] 1639003426 putative Mg ion binding site [ion binding]; other site 1639003427 putative aspartate binding site [chemical binding]; other site 1639003428 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1639003429 putative allosteric regulatory site; other site 1639003430 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1639003431 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 1639003432 glutamate racemase; Provisional; Region: PRK00865 1639003433 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1639003434 ribonuclease PH; Reviewed; Region: rph; PRK00173 1639003435 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1639003436 oligomer interface [polypeptide binding]; other site 1639003437 RNA binding site [nucleotide binding]; other site 1639003438 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1639003439 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1639003440 active site 1639003441 dimerization interface [polypeptide binding]; other site 1639003442 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1639003443 active site 1639003444 metal binding site [ion binding]; metal-binding site 1639003445 homotetramer interface [polypeptide binding]; other site 1639003446 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1639003447 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1639003448 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1639003449 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1639003450 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639003451 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639003452 catalytic core [active] 1639003453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639003454 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1639003455 ATP binding site [chemical binding]; other site 1639003456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639003457 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1639003458 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 1639003459 RNA binding site [nucleotide binding]; other site 1639003460 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 1639003461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639003462 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639003463 putative substrate translocation pore; other site 1639003464 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639003465 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639003466 ligand binding site [chemical binding]; other site 1639003467 flexible hinge region; other site 1639003468 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639003469 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1639003470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639003471 DNA-binding site [nucleotide binding]; DNA binding site 1639003472 UTRA domain; Region: UTRA; pfam07702 1639003473 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1639003474 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1639003475 Ca binding site [ion binding]; other site 1639003476 active site 1639003477 catalytic site [active] 1639003478 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639003479 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639003480 active site turn [active] 1639003481 phosphorylation site [posttranslational modification] 1639003482 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 1639003483 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639003484 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1639003485 nudix motif; other site 1639003486 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1639003487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1639003488 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1639003489 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1639003490 putative catalytic cysteine [active] 1639003491 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 1639003492 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1639003493 nucleotide binding site [chemical binding]; other site 1639003494 homotetrameric interface [polypeptide binding]; other site 1639003495 putative phosphate binding site [ion binding]; other site 1639003496 putative allosteric binding site; other site 1639003497 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1639003498 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1639003499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1639003500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639003501 non-specific DNA binding site [nucleotide binding]; other site 1639003502 salt bridge; other site 1639003503 sequence-specific DNA binding site [nucleotide binding]; other site 1639003504 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639003505 non-specific DNA binding site [nucleotide binding]; other site 1639003506 salt bridge; other site 1639003507 sequence-specific DNA binding site [nucleotide binding]; other site 1639003508 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1639003509 active site 1639003510 trigger factor; Provisional; Region: tig; PRK01490 1639003511 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1639003512 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1639003513 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1639003514 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1639003515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639003516 Walker A motif; other site 1639003517 ATP binding site [chemical binding]; other site 1639003518 Walker B motif; other site 1639003519 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1639003520 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1639003521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1639003522 Catalytic site [active] 1639003523 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1639003524 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1639003525 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1639003526 Catalytic site [active] 1639003527 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1639003528 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1639003529 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1639003530 Catalytic site [active] 1639003531 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1639003532 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1639003533 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1639003534 GTP/Mg2+ binding site [chemical binding]; other site 1639003535 G4 box; other site 1639003536 G5 box; other site 1639003537 G1 box; other site 1639003538 Switch I region; other site 1639003539 G2 box; other site 1639003540 G3 box; other site 1639003541 Switch II region; other site 1639003542 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1639003543 RNA/DNA hybrid binding site [nucleotide binding]; other site 1639003544 active site 1639003545 DNA protecting protein DprA; Region: dprA; TIGR00732 1639003546 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1639003547 DNA topoisomerase I; Validated; Region: PRK05582 1639003548 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1639003549 active site 1639003550 interdomain interaction site; other site 1639003551 putative metal-binding site [ion binding]; other site 1639003552 nucleotide binding site [chemical binding]; other site 1639003553 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1639003554 domain I; other site 1639003555 DNA binding groove [nucleotide binding] 1639003556 phosphate binding site [ion binding]; other site 1639003557 domain II; other site 1639003558 domain III; other site 1639003559 nucleotide binding site [chemical binding]; other site 1639003560 catalytic site [active] 1639003561 domain IV; other site 1639003562 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1639003563 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1639003564 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1639003565 Glucose inhibited division protein A; Region: GIDA; pfam01134 1639003566 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1639003567 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1639003568 active site 1639003569 DNA binding site [nucleotide binding] 1639003570 Int/Topo IB signature motif; other site 1639003571 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1639003572 active site 1639003573 HslU subunit interaction site [polypeptide binding]; other site 1639003574 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1639003575 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1639003576 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1639003577 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1639003578 transcriptional repressor CodY; Validated; Region: PRK04158 1639003579 CodY GAF-like domain; Region: CodY; pfam06018 1639003580 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1639003581 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1639003582 active site 1639003583 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 1639003584 active site 1639003585 catalytic residues [active] 1639003586 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1639003587 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1639003588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639003589 Mg2+ binding site [ion binding]; other site 1639003590 G-X-G motif; other site 1639003591 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1639003592 anchoring element; other site 1639003593 dimer interface [polypeptide binding]; other site 1639003594 ATP binding site [chemical binding]; other site 1639003595 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1639003596 active site 1639003597 metal binding site [ion binding]; metal-binding site 1639003598 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1639003599 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1639003600 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1639003601 CAP-like domain; other site 1639003602 active site 1639003603 primary dimer interface [polypeptide binding]; other site 1639003604 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1639003605 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1639003606 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639003607 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639003608 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639003609 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1639003610 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1639003611 catalytic triad [active] 1639003612 catalytic triad [active] 1639003613 oxyanion hole [active] 1639003614 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1639003615 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1639003616 active site 1639003617 catalytic site [active] 1639003618 metal binding site [ion binding]; metal-binding site 1639003619 dimer interface [polypeptide binding]; other site 1639003620 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1639003621 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1639003622 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1639003623 bacterial Hfq-like; Region: Hfq; cd01716 1639003624 hexamer interface [polypeptide binding]; other site 1639003625 Sm1 motif; other site 1639003626 RNA binding site [nucleotide binding]; other site 1639003627 Sm2 motif; other site 1639003628 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1639003629 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1639003630 HflX GTPase family; Region: HflX; cd01878 1639003631 G1 box; other site 1639003632 GTP/Mg2+ binding site [chemical binding]; other site 1639003633 Switch I region; other site 1639003634 G2 box; other site 1639003635 G3 box; other site 1639003636 Switch II region; other site 1639003637 G4 box; other site 1639003638 G5 box; other site 1639003639 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1639003640 Aluminium resistance protein; Region: Alum_res; pfam06838 1639003641 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1639003642 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1639003643 DNA binding residues [nucleotide binding] 1639003644 putative dimer interface [polypeptide binding]; other site 1639003645 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1639003646 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1639003647 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1639003648 arsenical pump membrane protein; Provisional; Region: PRK15445 1639003649 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1639003650 transmembrane helices; other site 1639003651 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1639003652 LexA repressor; Validated; Region: PRK00215 1639003653 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1639003654 putative DNA binding site [nucleotide binding]; other site 1639003655 putative Zn2+ binding site [ion binding]; other site 1639003656 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1639003657 Catalytic site [active] 1639003658 cell division suppressor protein YneA; Provisional; Region: PRK14125 1639003659 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1639003660 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1639003661 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1639003662 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1639003663 TPP-binding site [chemical binding]; other site 1639003664 dimer interface [polypeptide binding]; other site 1639003665 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1639003666 PYR/PP interface [polypeptide binding]; other site 1639003667 dimer interface [polypeptide binding]; other site 1639003668 TPP binding site [chemical binding]; other site 1639003669 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639003670 hypothetical protein; Provisional; Region: PRK01844 1639003671 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1639003672 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1639003673 ParB-like nuclease domain; Region: ParBc; pfam02195 1639003674 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1639003675 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1639003676 Active Sites [active] 1639003677 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1639003678 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1639003679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639003680 ATP binding site [chemical binding]; other site 1639003681 putative Mg++ binding site [ion binding]; other site 1639003682 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1639003683 putative nucleotide binding site [chemical binding]; other site 1639003684 uridine monophosphate binding site [chemical binding]; other site 1639003685 homohexameric interface [polypeptide binding]; other site 1639003686 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1639003687 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1639003688 hinge region; other site 1639003689 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1639003690 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1639003691 catalytic residue [active] 1639003692 putative FPP diphosphate binding site; other site 1639003693 putative FPP binding hydrophobic cleft; other site 1639003694 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1639003695 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1639003696 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1639003697 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1639003698 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1639003699 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1639003700 RIP metalloprotease RseP; Region: TIGR00054 1639003701 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1639003702 active site 1639003703 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1639003704 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1639003705 protein binding site [polypeptide binding]; other site 1639003706 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1639003707 putative substrate binding region [chemical binding]; other site 1639003708 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1639003709 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1639003710 dimer interface [polypeptide binding]; other site 1639003711 motif 1; other site 1639003712 active site 1639003713 motif 2; other site 1639003714 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1639003715 putative deacylase active site [active] 1639003716 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1639003717 active site 1639003718 motif 3; other site 1639003719 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1639003720 anticodon binding site; other site 1639003721 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1639003722 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1639003723 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1639003724 generic binding surface II; other site 1639003725 generic binding surface I; other site 1639003726 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1639003727 active site 1639003728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1639003729 active site 1639003730 catalytic site [active] 1639003731 substrate binding site [chemical binding]; other site 1639003732 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1639003733 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1639003734 Sm and related proteins; Region: Sm_like; cl00259 1639003735 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1639003736 putative oligomer interface [polypeptide binding]; other site 1639003737 putative RNA binding site [nucleotide binding]; other site 1639003738 NusA N-terminal domain; Region: NusA_N; pfam08529 1639003739 NusA N-terminal domain; Region: NusA_N; pfam08529 1639003740 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1639003741 RNA binding site [nucleotide binding]; other site 1639003742 homodimer interface [polypeptide binding]; other site 1639003743 Transcription elongation factor [Transcription]; Region: NusA; COG0195 1639003744 NusA-like KH domain; Region: KH_5; pfam13184 1639003745 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1639003746 G-X-X-G motif; other site 1639003747 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1639003748 putative RNA binding cleft [nucleotide binding]; other site 1639003749 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1639003750 translation initiation factor IF-2; Validated; Region: infB; PRK05306 1639003751 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1639003752 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1639003753 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1639003754 G1 box; other site 1639003755 putative GEF interaction site [polypeptide binding]; other site 1639003756 GTP/Mg2+ binding site [chemical binding]; other site 1639003757 Switch I region; other site 1639003758 G2 box; other site 1639003759 G3 box; other site 1639003760 Switch II region; other site 1639003761 G4 box; other site 1639003762 G5 box; other site 1639003763 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1639003764 Translation-initiation factor 2; Region: IF-2; pfam11987 1639003765 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1639003766 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1550 1639003767 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1639003768 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1639003769 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1639003770 RNA binding site [nucleotide binding]; other site 1639003771 active site 1639003772 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1639003773 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1639003774 active site 1639003775 Riboflavin kinase; Region: Flavokinase; smart00904 1639003776 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1639003777 16S/18S rRNA binding site [nucleotide binding]; other site 1639003778 S13e-L30e interaction site [polypeptide binding]; other site 1639003779 25S rRNA binding site [nucleotide binding]; other site 1639003780 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1639003781 RNase E interface [polypeptide binding]; other site 1639003782 trimer interface [polypeptide binding]; other site 1639003783 ribonuclease PH; Region: RNasePH; TIGR01966 1639003784 archaeal exosome-like complex exonuclease 1; Region: ECX1; TIGR02065 1639003785 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1639003786 RNase E interface [polypeptide binding]; other site 1639003787 trimer interface [polypeptide binding]; other site 1639003788 active site 1639003789 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1639003790 putative nucleic acid binding region [nucleotide binding]; other site 1639003791 G-X-X-G motif; other site 1639003792 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1639003793 RNA binding site [nucleotide binding]; other site 1639003794 domain interface; other site 1639003795 GTPase RsgA; Reviewed; Region: PRK01889 1639003796 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1639003797 RNA binding site [nucleotide binding]; other site 1639003798 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1639003799 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1639003800 GTP/Mg2+ binding site [chemical binding]; other site 1639003801 G4 box; other site 1639003802 G5 box; other site 1639003803 G1 box; other site 1639003804 Switch I region; other site 1639003805 G2 box; other site 1639003806 G3 box; other site 1639003807 Switch II region; other site 1639003808 YceG-like family; Region: YceG; pfam02618 1639003809 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1639003810 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1639003811 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1639003812 Rhomboid family; Region: Rhomboid; pfam01694 1639003813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639003814 TPR motif; other site 1639003815 TPR repeat; Region: TPR_11; pfam13414 1639003816 binding surface 1639003817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4483 1639003818 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1639003819 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639003820 nucleotide binding site [chemical binding]; other site 1639003821 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1639003822 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1639003823 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1639003824 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1639003825 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1639003826 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1639003827 Type II/IV secretion system protein; Region: T2SE; pfam00437 1639003828 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1639003829 Walker A motif; other site 1639003830 ATP binding site [chemical binding]; other site 1639003831 Walker B motif; other site 1639003832 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1639003833 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1639003834 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1639003835 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1639003836 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1639003837 tetramer interface [polypeptide binding]; other site 1639003838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639003839 catalytic residue [active] 1639003840 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1639003841 tetramer interface [polypeptide binding]; other site 1639003842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639003843 catalytic residue [active] 1639003844 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1639003845 active site residue [active] 1639003846 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1639003847 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1639003848 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1639003849 active site 1639003850 elongation factor P; Validated; Region: PRK00529 1639003851 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1639003852 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1639003853 RNA binding site [nucleotide binding]; other site 1639003854 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1639003855 RNA binding site [nucleotide binding]; other site 1639003856 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1639003857 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1639003858 carboxyltransferase (CT) interaction site; other site 1639003859 biotinylation site [posttranslational modification]; other site 1639003860 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1639003861 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1639003862 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1639003863 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1639003864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1639003865 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1639003866 putative RNA binding site [nucleotide binding]; other site 1639003867 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14170 1639003868 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1639003869 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1639003870 homodimer interface [polypeptide binding]; other site 1639003871 NADP binding site [chemical binding]; other site 1639003872 substrate binding site [chemical binding]; other site 1639003873 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1639003874 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1639003875 generic binding surface II; other site 1639003876 generic binding surface I; other site 1639003877 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14064 1639003878 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1639003879 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1639003880 substrate binding pocket [chemical binding]; other site 1639003881 chain length determination region; other site 1639003882 substrate-Mg2+ binding site; other site 1639003883 catalytic residues [active] 1639003884 aspartate-rich region 1; other site 1639003885 active site lid residues [active] 1639003886 aspartate-rich region 2; other site 1639003887 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1639003888 DNA-binding site [nucleotide binding]; DNA binding site 1639003889 RNA-binding motif; other site 1639003890 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1639003891 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1639003892 TPP-binding site; other site 1639003893 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1639003894 PYR/PP interface [polypeptide binding]; other site 1639003895 dimer interface [polypeptide binding]; other site 1639003896 TPP binding site [chemical binding]; other site 1639003897 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639003898 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1639003899 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639003900 RNA binding surface [nucleotide binding]; other site 1639003901 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1639003902 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1639003903 arginine repressor; Provisional; Region: PRK04280 1639003904 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1639003905 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1639003906 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1639003907 Walker A/P-loop; other site 1639003908 ATP binding site [chemical binding]; other site 1639003909 Q-loop/lid; other site 1639003910 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1639003911 ABC transporter signature motif; other site 1639003912 Walker B; other site 1639003913 D-loop; other site 1639003914 H-loop/switch region; other site 1639003915 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1639003916 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639003917 nucleotide binding site [chemical binding]; other site 1639003918 Acetokinase family; Region: Acetate_kinase; cl17229 1639003919 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1639003920 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639003921 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1639003922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1639003923 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1639003924 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1639003925 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1639003926 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1639003927 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1639003928 E3 interaction surface; other site 1639003929 lipoyl attachment site [posttranslational modification]; other site 1639003930 e3 binding domain; Region: E3_binding; pfam02817 1639003931 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1639003932 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1639003933 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1639003934 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1639003935 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639003936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639003937 active site 1639003938 phosphorylation site [posttranslational modification] 1639003939 intermolecular recognition site; other site 1639003940 dimerization interface [polypeptide binding]; other site 1639003941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639003942 DNA binding site [nucleotide binding] 1639003943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1639003944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639003945 dimerization interface [polypeptide binding]; other site 1639003946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639003947 dimer interface [polypeptide binding]; other site 1639003948 phosphorylation site [posttranslational modification] 1639003949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639003950 ATP binding site [chemical binding]; other site 1639003951 Mg2+ binding site [ion binding]; other site 1639003952 G-X-G motif; other site 1639003953 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1639003954 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1639003955 acylphosphatase; Provisional; Region: PRK14443 1639003956 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 1639003957 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1639003958 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1639003959 homotetramer interface [polypeptide binding]; other site 1639003960 FMN binding site [chemical binding]; other site 1639003961 homodimer contacts [polypeptide binding]; other site 1639003962 putative active site [active] 1639003963 putative substrate binding site [chemical binding]; other site 1639003964 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639003965 phosphate binding site [ion binding]; other site 1639003966 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1639003967 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1639003968 active site residue [active] 1639003969 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1639003970 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1639003971 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639003972 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1639003973 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1639003974 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1639003975 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1639003976 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1639003977 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06928 1639003978 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1639003979 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1639003980 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1639003981 ligand binding site [chemical binding]; other site 1639003982 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1639003983 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1639003984 Walker A/P-loop; other site 1639003985 ATP binding site [chemical binding]; other site 1639003986 Q-loop/lid; other site 1639003987 ABC transporter signature motif; other site 1639003988 Walker B; other site 1639003989 D-loop; other site 1639003990 H-loop/switch region; other site 1639003991 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1639003992 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1639003993 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1639003994 TM-ABC transporter signature motif; other site 1639003995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1639003996 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1639003997 TM-ABC transporter signature motif; other site 1639003998 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1639003999 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1639004000 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1639004001 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1639004002 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1639004003 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1639004004 classical (c) SDRs; Region: SDR_c; cd05233 1639004005 NAD(P) binding site [chemical binding]; other site 1639004006 active site 1639004007 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1639004008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639004009 non-specific DNA binding site [nucleotide binding]; other site 1639004010 salt bridge; other site 1639004011 sequence-specific DNA binding site [nucleotide binding]; other site 1639004012 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1639004013 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1639004014 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1639004015 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1639004016 putative MPT binding site; other site 1639004017 Competence-damaged protein; Region: CinA; cl00666 1639004018 Competence-damaged protein; Region: CinA; pfam02464 1639004019 recombinase A; Provisional; Region: recA; PRK09354 1639004020 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1639004021 hexamer interface [polypeptide binding]; other site 1639004022 Walker A motif; other site 1639004023 ATP binding site [chemical binding]; other site 1639004024 Walker B motif; other site 1639004025 phosphodiesterase; Provisional; Region: PRK12704 1639004026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639004027 Zn2+ binding site [ion binding]; other site 1639004028 Mg2+ binding site [ion binding]; other site 1639004029 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1639004030 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639004031 Coenzyme A binding pocket [chemical binding]; other site 1639004032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1639004033 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1639004034 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1639004035 putative active site [active] 1639004036 metal binding site [ion binding]; metal-binding site 1639004037 homodimer binding site [polypeptide binding]; other site 1639004038 Predicted membrane protein [Function unknown]; Region: COG4550 1639004039 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1639004040 MutS domain I; Region: MutS_I; pfam01624 1639004041 MutS domain II; Region: MutS_II; pfam05188 1639004042 MutS domain III; Region: MutS_III; pfam05192 1639004043 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1639004044 Walker A/P-loop; other site 1639004045 ATP binding site [chemical binding]; other site 1639004046 Q-loop/lid; other site 1639004047 ABC transporter signature motif; other site 1639004048 Walker B; other site 1639004049 D-loop; other site 1639004050 H-loop/switch region; other site 1639004051 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1639004052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639004053 ATP binding site [chemical binding]; other site 1639004054 Mg2+ binding site [ion binding]; other site 1639004055 G-X-G motif; other site 1639004056 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1639004057 ATP binding site [chemical binding]; other site 1639004058 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1639004059 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1639004060 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1639004061 Pyruvate formate lyase 1; Region: PFL1; cd01678 1639004062 coenzyme A binding site [chemical binding]; other site 1639004063 active site 1639004064 catalytic residues [active] 1639004065 glycine loop; other site 1639004066 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1639004067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1639004068 FeS/SAM binding site; other site 1639004069 Predicted transcriptional regulators [Transcription]; Region: COG1695 1639004070 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1639004071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639004072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639004073 putative substrate translocation pore; other site 1639004074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639004075 non-specific DNA binding site [nucleotide binding]; other site 1639004076 salt bridge; other site 1639004077 sequence-specific DNA binding site [nucleotide binding]; other site 1639004078 AAA domain; Region: AAA_17; pfam13207 1639004079 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639004080 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639004081 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639004082 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639004083 putative acyltransferase; Provisional; Region: PRK05790 1639004084 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1639004085 dimer interface [polypeptide binding]; other site 1639004086 active site 1639004087 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1639004088 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1639004089 dimer interface [polypeptide binding]; other site 1639004090 active site 1639004091 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1639004092 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1639004093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639004094 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1639004095 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1639004096 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1639004097 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1639004098 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1639004099 FAD binding domain; Region: FAD_binding_4; pfam01565 1639004100 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1639004101 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1639004102 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1639004103 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1639004104 Walker A/P-loop; other site 1639004105 ATP binding site [chemical binding]; other site 1639004106 Q-loop/lid; other site 1639004107 ABC transporter signature motif; other site 1639004108 Walker B; other site 1639004109 D-loop; other site 1639004110 H-loop/switch region; other site 1639004111 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1639004112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639004113 dimer interface [polypeptide binding]; other site 1639004114 conserved gate region; other site 1639004115 ABC-ATPase subunit interface; other site 1639004116 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1639004117 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1639004118 manganese transport protein MntH; Reviewed; Region: PRK00701 1639004119 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1639004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639004121 dimer interface [polypeptide binding]; other site 1639004122 conserved gate region; other site 1639004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1639004124 ABC-ATPase subunit interface; other site 1639004125 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1639004126 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1639004127 dimerization interface [polypeptide binding]; other site 1639004128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639004129 dimer interface [polypeptide binding]; other site 1639004130 conserved gate region; other site 1639004131 putative PBP binding loops; other site 1639004132 ABC-ATPase subunit interface; other site 1639004133 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1639004134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004136 Walker A/P-loop; other site 1639004137 ATP binding site [chemical binding]; other site 1639004138 Q-loop/lid; other site 1639004139 Predicted membrane protein [Function unknown]; Region: COG3859 1639004140 Protein of unknown function (DUF419); Region: DUF419; cl15265 1639004141 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1639004142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639004143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639004144 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1639004145 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1639004146 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639004147 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1639004148 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1639004149 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1639004150 dimer interface [polypeptide binding]; other site 1639004151 active site 1639004152 catalytic residue [active] 1639004153 aspartate kinase I; Reviewed; Region: PRK08210 1639004154 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1639004155 nucleotide binding site [chemical binding]; other site 1639004156 substrate binding site [chemical binding]; other site 1639004157 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1639004158 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1639004159 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1639004160 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1639004161 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1639004162 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1639004163 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1639004164 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1639004165 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1639004166 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1639004167 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 1639004168 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1639004169 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1639004170 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1639004171 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1639004172 Predicted membrane protein [Function unknown]; Region: COG4392 1639004173 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1639004174 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1639004175 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1639004176 metal binding site 2 [ion binding]; metal-binding site 1639004177 putative DNA binding helix; other site 1639004178 metal binding site 1 [ion binding]; metal-binding site 1639004179 dimer interface [polypeptide binding]; other site 1639004180 structural Zn2+ binding site [ion binding]; other site 1639004181 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1639004182 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639004183 ABC-ATPase subunit interface; other site 1639004184 dimer interface [polypeptide binding]; other site 1639004185 putative PBP binding regions; other site 1639004186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004187 H-loop/switch region; other site 1639004188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004189 ABC transporter signature motif; other site 1639004190 Walker B; other site 1639004191 D-loop; other site 1639004192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004193 Walker A/P-loop; other site 1639004194 ATP binding site [chemical binding]; other site 1639004195 DHHA2 domain; Region: DHHA2; pfam02833 1639004196 DHHA2 domain; Region: DHHA2; pfam02833 1639004197 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1639004198 endonuclease IV; Provisional; Region: PRK01060 1639004199 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1639004200 AP (apurinic/apyrimidinic) site pocket; other site 1639004201 DNA interaction; other site 1639004202 Metal-binding active site; metal-binding site 1639004203 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1639004204 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1639004205 ATP binding site [chemical binding]; other site 1639004206 Mg++ binding site [ion binding]; other site 1639004207 motif III; other site 1639004208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639004209 nucleotide binding region [chemical binding]; other site 1639004210 ATP-binding site [chemical binding]; other site 1639004211 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1639004212 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1639004213 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1639004214 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1639004215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1639004216 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1639004217 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1639004218 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1639004219 Family of unknown function (DUF633); Region: DUF633; pfam04816 1639004220 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1639004221 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1639004222 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1639004223 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1639004224 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1639004225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1639004226 DNA binding residues [nucleotide binding] 1639004227 CHC2 zinc finger; Region: zf-CHC2; cl17510 1639004228 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1639004229 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1639004230 active site 1639004231 metal binding site [ion binding]; metal-binding site 1639004232 interdomain interaction site; other site 1639004233 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1639004234 CHC2 zinc finger; Region: zf-CHC2; cl17510 1639004235 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1671 1639004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1806 1639004237 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1639004238 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1639004239 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1639004240 active site 1639004241 motif 3; other site 1639004242 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1639004243 motif 1; other site 1639004244 dimer interface [polypeptide binding]; other site 1639004245 active site 1639004246 motif 2; other site 1639004247 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1639004248 Recombination protein O N terminal; Region: RecO_N; pfam11967 1639004249 Recombination protein O C terminal; Region: RecO_C; pfam02565 1639004250 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1639004251 GTPase Era; Reviewed; Region: era; PRK00089 1639004252 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1639004253 G1 box; other site 1639004254 GTP/Mg2+ binding site [chemical binding]; other site 1639004255 Switch I region; other site 1639004256 G2 box; other site 1639004257 Switch II region; other site 1639004258 G3 box; other site 1639004259 G4 box; other site 1639004260 G5 box; other site 1639004261 KH domain; Region: KH_2; pfam07650 1639004262 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1639004263 active site 1639004264 catalytic motif [active] 1639004265 Zn binding site [ion binding]; other site 1639004266 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1639004267 metal-binding heat shock protein; Provisional; Region: PRK00016 1639004268 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1639004269 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1639004270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639004271 Zn2+ binding site [ion binding]; other site 1639004272 Mg2+ binding site [ion binding]; other site 1639004273 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1639004274 PhoH-like protein; Region: PhoH; pfam02562 1639004275 Yqey-like protein; Region: YqeY; pfam09424 1639004276 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1639004277 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 1639004278 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 1639004279 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1639004280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639004281 S-adenosylmethionine binding site [chemical binding]; other site 1639004282 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1639004283 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1639004284 dimer interface [polypeptide binding]; other site 1639004285 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1639004286 HSP70 interaction site [polypeptide binding]; other site 1639004287 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1639004288 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1639004289 nucleotide binding site [chemical binding]; other site 1639004290 NEF interaction site [polypeptide binding]; other site 1639004291 SBD interface [polypeptide binding]; other site 1639004292 heat shock protein GrpE; Provisional; Region: PRK14140 1639004293 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1639004294 dimer interface [polypeptide binding]; other site 1639004295 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1639004296 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1639004297 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1639004298 HemN C-terminal domain; Region: HemN_C; pfam06969 1639004299 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1639004300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1639004301 FeS/SAM binding site; other site 1639004302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639004303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639004304 NAD(P) binding site [chemical binding]; other site 1639004305 active site 1639004306 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639004307 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639004308 DNA binding residues [nucleotide binding] 1639004309 putative dimer interface [polypeptide binding]; other site 1639004310 GTP-binding protein LepA; Provisional; Region: PRK05433 1639004311 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1639004312 G1 box; other site 1639004313 putative GEF interaction site [polypeptide binding]; other site 1639004314 GTP/Mg2+ binding site [chemical binding]; other site 1639004315 Switch I region; other site 1639004316 G2 box; other site 1639004317 G3 box; other site 1639004318 Switch II region; other site 1639004319 G4 box; other site 1639004320 G5 box; other site 1639004321 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1639004322 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1639004323 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1639004324 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1639004325 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1639004326 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1639004327 Competence protein; Region: Competence; pfam03772 1639004328 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1639004329 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1639004330 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639004331 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1639004332 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1639004333 Competence protein; Region: Competence; pfam03772 1639004334 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1639004335 catalytic motif [active] 1639004336 Zn binding site [ion binding]; other site 1639004337 SLBB domain; Region: SLBB; pfam10531 1639004338 comEA protein; Region: comE; TIGR01259 1639004339 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1639004340 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1639004341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639004342 S-adenosylmethionine binding site [chemical binding]; other site 1639004343 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1639004344 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639004345 Zn2+ binding site [ion binding]; other site 1639004346 Mg2+ binding site [ion binding]; other site 1639004347 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1639004348 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 1639004349 active site 1639004350 (T/H)XGH motif; other site 1639004351 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1639004352 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 1639004353 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1639004354 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1639004355 shikimate binding site; other site 1639004356 NAD(P) binding site [chemical binding]; other site 1639004357 GTPase YqeH; Provisional; Region: PRK13796 1639004358 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1639004359 GTP/Mg2+ binding site [chemical binding]; other site 1639004360 G4 box; other site 1639004361 G5 box; other site 1639004362 G1 box; other site 1639004363 Switch I region; other site 1639004364 G2 box; other site 1639004365 G3 box; other site 1639004366 Switch II region; other site 1639004367 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1639004368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639004369 motif II; other site 1639004370 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1639004371 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1639004372 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1639004373 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 1639004374 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1639004375 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1639004376 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1639004377 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1639004378 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1639004379 Sugar specificity; other site 1639004380 Pyrimidine base specificity; other site 1639004381 ATP-binding site [chemical binding]; other site 1639004382 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1639004383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639004384 S-adenosylmethionine binding site [chemical binding]; other site 1639004385 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1639004386 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1639004387 dimerization interface [polypeptide binding]; other site 1639004388 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1639004389 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1639004390 hypothetical protein; Provisional; Region: PRK13678 1639004391 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1639004392 hypothetical protein; Provisional; Region: PRK05473 1639004393 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1639004394 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1639004395 motif 1; other site 1639004396 active site 1639004397 motif 2; other site 1639004398 motif 3; other site 1639004399 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1639004400 DHHA1 domain; Region: DHHA1; pfam02272 1639004401 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639004402 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639004403 Walker A/P-loop; other site 1639004404 ATP binding site [chemical binding]; other site 1639004405 Q-loop/lid; other site 1639004406 ABC transporter signature motif; other site 1639004407 Walker B; other site 1639004408 D-loop; other site 1639004409 H-loop/switch region; other site 1639004410 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639004411 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1639004412 FtsX-like permease family; Region: FtsX; pfam02687 1639004413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639004414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639004415 active site 1639004416 phosphorylation site [posttranslational modification] 1639004417 intermolecular recognition site; other site 1639004418 dimerization interface [polypeptide binding]; other site 1639004419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639004420 DNA binding site [nucleotide binding] 1639004421 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1639004422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639004423 dimerization interface [polypeptide binding]; other site 1639004424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639004425 dimer interface [polypeptide binding]; other site 1639004426 phosphorylation site [posttranslational modification] 1639004427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639004428 ATP binding site [chemical binding]; other site 1639004429 Mg2+ binding site [ion binding]; other site 1639004430 G-X-G motif; other site 1639004431 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1639004432 AAA domain; Region: AAA_30; pfam13604 1639004433 Family description; Region: UvrD_C_2; pfam13538 1639004434 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639004435 binding surface 1639004436 TPR motif; other site 1639004437 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1639004438 TPR repeat; Region: TPR_11; pfam13414 1639004439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639004440 binding surface 1639004441 TPR motif; other site 1639004442 TPR repeat; Region: TPR_11; pfam13414 1639004443 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1639004444 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1639004445 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1639004446 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1639004447 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1639004448 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639004449 catalytic residue [active] 1639004450 ATPase related to the helicase subunit of the Holliday junction resolvase [DNA replication, recombination, and repair]; Region: MGS1; COG2256 1639004451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639004452 Walker A motif; other site 1639004453 ATP binding site [chemical binding]; other site 1639004454 Walker B motif; other site 1639004455 arginine finger; other site 1639004456 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1639004457 Predicted transcriptional regulator [Transcription]; Region: COG1959 1639004458 Transcriptional regulator; Region: Rrf2; pfam02082 1639004459 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1639004460 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1639004461 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1639004462 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1639004463 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1639004464 dimer interface [polypeptide binding]; other site 1639004465 anticodon binding site; other site 1639004466 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1639004467 homodimer interface [polypeptide binding]; other site 1639004468 motif 1; other site 1639004469 active site 1639004470 motif 2; other site 1639004471 GAD domain; Region: GAD; pfam02938 1639004472 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1639004473 active site 1639004474 motif 3; other site 1639004475 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1639004476 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1639004477 dimer interface [polypeptide binding]; other site 1639004478 motif 1; other site 1639004479 active site 1639004480 motif 2; other site 1639004481 motif 3; other site 1639004482 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1639004483 anticodon binding site; other site 1639004484 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 1639004485 Bacterial SH3 domain; Region: SH3_3; pfam08239 1639004486 Bacterial SH3 domain; Region: SH3_3; pfam08239 1639004487 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1639004488 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1639004489 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1639004490 active site 1639004491 metal binding site [ion binding]; metal-binding site 1639004492 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1639004493 putative active site [active] 1639004494 dimerization interface [polypeptide binding]; other site 1639004495 putative tRNAtyr binding site [nucleotide binding]; other site 1639004496 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1639004497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639004498 Zn2+ binding site [ion binding]; other site 1639004499 Mg2+ binding site [ion binding]; other site 1639004500 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1639004501 synthetase active site [active] 1639004502 NTP binding site [chemical binding]; other site 1639004503 metal binding site [ion binding]; metal-binding site 1639004504 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1639004505 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1639004506 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639004507 active site 1639004508 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1639004509 DHH family; Region: DHH; pfam01368 1639004510 DHHA1 domain; Region: DHHA1; pfam02272 1639004511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1639004512 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1639004513 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 1639004514 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1639004515 Protein export membrane protein; Region: SecD_SecF; cl14618 1639004516 Protein export membrane protein; Region: SecD_SecF; pfam02355 1639004517 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1639004518 Preprotein translocase subunit; Region: YajC; pfam02699 1639004519 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1639004520 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1639004521 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1639004522 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1639004523 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1639004524 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1639004525 Walker B motif; other site 1639004526 arginine finger; other site 1639004527 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1639004528 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1639004529 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1639004530 RuvA N terminal domain; Region: RuvA_N; pfam01330 1639004531 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1639004532 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1639004533 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639004534 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1639004535 NAD binding site [chemical binding]; other site 1639004536 dimer interface [polypeptide binding]; other site 1639004537 substrate binding site [chemical binding]; other site 1639004538 hypothetical protein; Validated; Region: PRK00110 1639004539 prephenate dehydratase; Provisional; Region: PRK11898 1639004540 Prephenate dehydratase; Region: PDT; pfam00800 1639004541 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1639004542 putative L-Phe binding site [chemical binding]; other site 1639004543 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1639004544 GTP1/OBG; Region: GTP1_OBG; pfam01018 1639004545 Obg GTPase; Region: Obg; cd01898 1639004546 G1 box; other site 1639004547 GTP/Mg2+ binding site [chemical binding]; other site 1639004548 Switch I region; other site 1639004549 G2 box; other site 1639004550 G3 box; other site 1639004551 Switch II region; other site 1639004552 G4 box; other site 1639004553 G5 box; other site 1639004554 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1639004555 glycerol kinase; Provisional; Region: glpK; PRK00047 1639004556 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1639004557 N- and C-terminal domain interface [polypeptide binding]; other site 1639004558 active site 1639004559 MgATP binding site [chemical binding]; other site 1639004560 catalytic site [active] 1639004561 metal binding site [ion binding]; metal-binding site 1639004562 glycerol binding site [chemical binding]; other site 1639004563 homotetramer interface [polypeptide binding]; other site 1639004564 homodimer interface [polypeptide binding]; other site 1639004565 FBP binding site [chemical binding]; other site 1639004566 protein IIAGlc interface [polypeptide binding]; other site 1639004567 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1639004568 amphipathic channel; other site 1639004569 Asn-Pro-Ala signature motifs; other site 1639004570 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1639004571 hypothetical protein; Provisional; Region: PRK14553 1639004572 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1639004573 Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530 1639004574 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1639004575 homodimer interface [polypeptide binding]; other site 1639004576 oligonucleotide binding site [chemical binding]; other site 1639004577 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1639004578 Switch I; other site 1639004579 Switch II; other site 1639004580 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1639004581 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1639004582 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 1639004583 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 1639004584 Protein of unknown function (DUF972); Region: DUF972; pfam06156 1639004585 rod shape-determining protein MreC; Region: MreC; pfam04085 1639004586 rod shape-determining protein MreB; Provisional; Region: PRK13927 1639004587 MreB and similar proteins; Region: MreB_like; cd10225 1639004588 nucleotide binding site [chemical binding]; other site 1639004589 Mg binding site [ion binding]; other site 1639004590 putative protofilament interaction site [polypeptide binding]; other site 1639004591 RodZ interaction site [polypeptide binding]; other site 1639004592 hypothetical protein; Reviewed; Region: PRK00024 1639004593 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1639004594 MPN+ (JAMM) motif; other site 1639004595 Zinc-binding site [ion binding]; other site 1639004596 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1639004597 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1639004598 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1639004599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1639004600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1639004601 AAA domain; Region: AAA_14; pfam13173 1639004602 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1639004603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639004604 active site 1639004605 HIGH motif; other site 1639004606 nucleotide binding site [chemical binding]; other site 1639004607 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1639004608 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1639004609 active site 1639004610 KMSKS motif; other site 1639004611 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1639004612 tRNA binding surface [nucleotide binding]; other site 1639004613 anticodon binding site; other site 1639004614 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1639004615 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1639004616 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1639004617 inhibitor-cofactor binding pocket; inhibition site 1639004618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639004619 catalytic residue [active] 1639004620 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1639004621 dimer interface [polypeptide binding]; other site 1639004622 active site 1639004623 Schiff base residues; other site 1639004624 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1639004625 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1639004626 active site 1639004627 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1639004628 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1639004629 domain interfaces; other site 1639004630 active site 1639004631 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1639004632 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1639004633 tRNA; other site 1639004634 putative tRNA binding site [nucleotide binding]; other site 1639004635 putative NADP binding site [chemical binding]; other site 1639004636 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1639004637 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1639004638 G1 box; other site 1639004639 GTP/Mg2+ binding site [chemical binding]; other site 1639004640 Switch I region; other site 1639004641 G2 box; other site 1639004642 G3 box; other site 1639004643 Switch II region; other site 1639004644 G4 box; other site 1639004645 G5 box; other site 1639004646 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1639004647 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1639004648 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1639004649 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1639004650 active site 1639004651 dimer interface [polypeptide binding]; other site 1639004652 motif 1; other site 1639004653 motif 2; other site 1639004654 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1639004655 anticodon binding site; other site 1639004656 primosomal protein DnaI; Reviewed; Region: PRK08939 1639004657 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1639004658 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1639004659 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1639004660 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1639004661 ATP cone domain; Region: ATP-cone; pfam03477 1639004662 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1639004663 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1639004664 CoA-binding site [chemical binding]; other site 1639004665 ATP-binding [chemical binding]; other site 1639004666 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1639004667 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1639004668 DNA binding site [nucleotide binding] 1639004669 catalytic residue [active] 1639004670 H2TH interface [polypeptide binding]; other site 1639004671 putative catalytic residues [active] 1639004672 turnover-facilitating residue; other site 1639004673 intercalation triad [nucleotide binding]; other site 1639004674 8OG recognition residue [nucleotide binding]; other site 1639004675 putative reading head residues; other site 1639004676 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1639004677 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1639004678 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1639004679 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1639004680 active site 1639004681 DNA binding site [nucleotide binding] 1639004682 catalytic site [active] 1639004683 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1639004684 active site 1639004685 catalytic site [active] 1639004686 substrate binding site [chemical binding]; other site 1639004687 5'-3' exonuclease; Region: 53EXOc; smart00475 1639004688 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1639004689 active site 1639004690 metal binding site 1 [ion binding]; metal-binding site 1639004691 putative 5' ssDNA interaction site; other site 1639004692 metal binding site 3; metal-binding site 1639004693 metal binding site 2 [ion binding]; metal-binding site 1639004694 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1639004695 putative DNA binding site [nucleotide binding]; other site 1639004696 putative metal binding site [ion binding]; other site 1639004697 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1639004698 isocitrate dehydrogenase; Validated; Region: PRK07362 1639004699 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1639004700 dimer interface [polypeptide binding]; other site 1639004701 Citrate synthase; Region: Citrate_synt; pfam00285 1639004702 active site 1639004703 citrylCoA binding site [chemical binding]; other site 1639004704 oxalacetate/citrate binding site [chemical binding]; other site 1639004705 coenzyme A binding site [chemical binding]; other site 1639004706 catalytic triad [active] 1639004707 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1639004708 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1639004709 pyruvate kinase; Provisional; Region: PRK06354 1639004710 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1639004711 domain interfaces; other site 1639004712 active site 1639004713 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1639004714 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1639004715 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1639004716 active site 1639004717 ADP/pyrophosphate binding site [chemical binding]; other site 1639004718 dimerization interface [polypeptide binding]; other site 1639004719 allosteric effector site; other site 1639004720 fructose-1,6-bisphosphate binding site; other site 1639004721 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1639004722 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1639004723 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1639004724 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1639004725 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1639004726 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1639004727 generic binding surface I; other site 1639004728 generic binding surface II; other site 1639004729 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1639004730 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 1639004731 active site 1639004732 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1639004733 DHH family; Region: DHH; pfam01368 1639004734 DHHA1 domain; Region: DHHA1; pfam02272 1639004735 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1639004736 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1639004737 FOG: CBS domain [General function prediction only]; Region: COG0517 1639004738 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1639004739 DRTGG domain; Region: DRTGG; pfam07085 1639004740 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1639004741 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1639004742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1639004743 DNA-binding site [nucleotide binding]; DNA binding site 1639004744 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1639004745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1639004746 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1639004747 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1639004748 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1639004749 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1639004750 active site 1639004751 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1639004752 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1639004753 hexamer interface [polypeptide binding]; other site 1639004754 ligand binding site [chemical binding]; other site 1639004755 putative active site [active] 1639004756 NAD(P) binding site [chemical binding]; other site 1639004757 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1639004758 Ligand Binding Site [chemical binding]; other site 1639004759 Acetokinase family; Region: Acetate_kinase; cl17229 1639004760 Acetokinase family; Region: Acetate_kinase; cl17229 1639004761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639004762 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1639004763 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1639004764 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1639004765 dimer interface [polypeptide binding]; other site 1639004766 catalytic triad [active] 1639004767 peroxidatic and resolving cysteines [active] 1639004768 RDD family; Region: RDD; pfam06271 1639004769 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1639004770 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1639004771 tandem repeat interface [polypeptide binding]; other site 1639004772 oligomer interface [polypeptide binding]; other site 1639004773 active site residues [active] 1639004774 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 1639004775 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1639004776 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1639004777 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1639004778 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1639004779 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 1639004780 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1639004781 inhibitor-cofactor binding pocket; inhibition site 1639004782 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639004783 catalytic residue [active] 1639004784 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1639004785 nucleotide binding site [chemical binding]; other site 1639004786 N-acetyl-L-glutamate binding site [chemical binding]; other site 1639004787 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1639004788 heterotetramer interface [polypeptide binding]; other site 1639004789 active site pocket [active] 1639004790 cleavage site 1639004791 N-acetyl-gamma-glutamyl-phosphate reductase, common form; Region: argC; TIGR01850 1639004792 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1639004793 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1639004794 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1639004795 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1639004796 Ligand Binding Site [chemical binding]; other site 1639004797 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1639004798 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1639004799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639004800 catalytic residue [active] 1639004801 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 1639004802 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1639004803 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1639004804 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1639004805 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639004806 RNA binding surface [nucleotide binding]; other site 1639004807 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639004808 RNA binding surface [nucleotide binding]; other site 1639004809 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639004810 active site 1639004811 KMSKS motif; other site 1639004812 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639004813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1639004814 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1639004815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639004816 DNA binding site [nucleotide binding] 1639004817 domain linker motif; other site 1639004818 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1639004819 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1639004820 Chorismate mutase type II; Region: CM_2; cl00693 1639004821 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1639004822 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1639004823 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1639004824 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1639004825 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1639004826 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1639004827 dimer interface [polypeptide binding]; other site 1639004828 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1639004829 catalytic triad [active] 1639004830 peroxidatic and resolving cysteines [active] 1639004831 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1639004832 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1639004833 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1639004834 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1639004835 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1639004836 DNA translocase FtsK; Provisional; Region: PRK10263 1639004837 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1639004838 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1639004839 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1639004840 putative tRNA-binding site [nucleotide binding]; other site 1639004841 hypothetical protein; Provisional; Region: PRK13668 1639004842 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639004843 catalytic residues [active] 1639004844 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1639004845 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1639004846 oligomer interface [polypeptide binding]; other site 1639004847 active site 1639004848 metal binding site [ion binding]; metal-binding site 1639004849 Predicted small secreted protein [Function unknown]; Region: COG5584 1639004850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1937 1639004851 putative homodimer interface [polypeptide binding]; other site 1639004852 putative homotetramer interface [polypeptide binding]; other site 1639004853 putative allosteric switch controlling residues; other site 1639004854 putative metal binding site [ion binding]; other site 1639004855 putative homodimer-homodimer interface [polypeptide binding]; other site 1639004856 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639004857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639004858 S-adenosylmethionine binding site [chemical binding]; other site 1639004859 Phosphotransferase enzyme family; Region: APH; pfam01636 1639004860 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1639004861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639004862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1639004863 MarR family; Region: MarR; pfam01047 1639004864 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1639004865 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1639004866 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1639004867 homodimer interface [polypeptide binding]; other site 1639004868 substrate-cofactor binding pocket; other site 1639004869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639004870 catalytic residue [active] 1639004871 dipeptidase PepV; Reviewed; Region: PRK07318 1639004872 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1639004873 active site 1639004874 metal binding site [ion binding]; metal-binding site 1639004875 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 1639004876 nudix motif; other site 1639004877 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1639004878 putative substrate binding site [chemical binding]; other site 1639004879 putative ATP binding site [chemical binding]; other site 1639004880 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1639004881 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1639004882 active site 1639004883 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1639004884 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1639004885 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639004886 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639004887 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1639004888 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1639004889 substrate binding site [chemical binding]; other site 1639004890 active site 1639004891 catalytic residues [active] 1639004892 heterodimer interface [polypeptide binding]; other site 1639004893 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1639004894 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1639004895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639004896 catalytic residue [active] 1639004897 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1639004898 active site 1639004899 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1639004900 active site 1639004901 ribulose/triose binding site [chemical binding]; other site 1639004902 phosphate binding site [ion binding]; other site 1639004903 substrate (anthranilate) binding pocket [chemical binding]; other site 1639004904 product (indole) binding pocket [chemical binding]; other site 1639004905 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1639004906 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1639004907 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1639004908 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1639004909 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1639004910 glutamine binding [chemical binding]; other site 1639004911 catalytic triad [active] 1639004912 anthranilate synthase component I; Provisional; Region: PRK13570 1639004913 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1639004914 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1639004915 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1639004916 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1639004917 putative catalytic cysteine [active] 1639004918 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1639004919 putative active site [active] 1639004920 metal binding site [ion binding]; metal-binding site 1639004921 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1639004922 dimer interface [polypeptide binding]; other site 1639004923 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1639004924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004925 Walker A/P-loop; other site 1639004926 ATP binding site [chemical binding]; other site 1639004927 Q-loop/lid; other site 1639004928 ABC transporter signature motif; other site 1639004929 Walker B; other site 1639004930 D-loop; other site 1639004931 H-loop/switch region; other site 1639004932 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1639004933 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1639004934 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1639004935 putative dimer interface [polypeptide binding]; other site 1639004936 catalytic triad [active] 1639004937 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1639004938 aconitate hydratase; Validated; Region: PRK09277 1639004939 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1639004940 substrate binding site [chemical binding]; other site 1639004941 ligand binding site [chemical binding]; other site 1639004942 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1639004943 substrate binding site [chemical binding]; other site 1639004944 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1639004945 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1639004946 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639004947 ATP binding site [chemical binding]; other site 1639004948 putative Mg++ binding site [ion binding]; other site 1639004949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639004950 nucleotide binding region [chemical binding]; other site 1639004951 ATP-binding site [chemical binding]; other site 1639004952 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1639004953 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1639004954 SWIM zinc finger; Region: SWIM; pfam04434 1639004955 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1639004956 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1639004957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004958 Walker B; other site 1639004959 D-loop; other site 1639004960 H-loop/switch region; other site 1639004961 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1639004962 AAA domain; Region: AAA_23; pfam13476 1639004963 Walker A/P-loop; other site 1639004964 ATP binding site [chemical binding]; other site 1639004965 Q-loop/lid; other site 1639004966 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1639004967 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1639004968 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1639004969 active site 1639004970 metal binding site [ion binding]; metal-binding site 1639004971 DNA binding site [nucleotide binding] 1639004972 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1639004973 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1639004974 putative acyl-acceptor binding pocket; other site 1639004975 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1639004976 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1639004977 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004978 H-loop/switch region; other site 1639004979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639004981 Q-loop/lid; other site 1639004982 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639004983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004984 Walker A/P-loop; other site 1639004985 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639004986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639004987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639004988 ABC transporter signature motif; other site 1639004989 Walker B; other site 1639004990 D-loop; other site 1639004991 H-loop/switch region; other site 1639004992 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639004993 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1639004994 Walker A/P-loop; other site 1639004995 ATP binding site [chemical binding]; other site 1639004996 Q-loop/lid; other site 1639004997 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1639004998 active site 1639004999 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1639005000 elongation factor Ts; Provisional; Region: tsf; PRK09377 1639005001 UBA/TS-N domain; Region: UBA; pfam00627 1639005002 Elongation factor TS; Region: EF_TS; pfam00889 1639005003 Elongation factor TS; Region: EF_TS; pfam00889 1639005004 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1639005005 rRNA interaction site [nucleotide binding]; other site 1639005006 S8 interaction site; other site 1639005007 putative laminin-1 binding site; other site 1639005008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639005009 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1639005010 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1639005011 active site 1639005012 KMSKS motif; other site 1639005013 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1639005014 tRNA binding surface [nucleotide binding]; other site 1639005015 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1639005016 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639005017 active site 1639005018 HIGH motif; other site 1639005019 nucleotide binding site [chemical binding]; other site 1639005020 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1639005021 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1639005022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639005023 S-adenosylmethionine binding site [chemical binding]; other site 1639005024 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1639005025 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1639005026 active site 1639005027 dimer interface [polypeptide binding]; other site 1639005028 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1639005029 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1639005030 Ligand Binding Site [chemical binding]; other site 1639005031 Molecular Tunnel; other site 1639005032 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1639005033 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1639005034 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1639005035 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1639005036 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1639005037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1639005038 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1639005039 NAD binding site [chemical binding]; other site 1639005040 dimer interface [polypeptide binding]; other site 1639005041 substrate binding site [chemical binding]; other site 1639005042 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 1639005043 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 1639005044 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 1639005045 nudix motif; other site 1639005046 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1639005047 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1639005048 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1639005049 metal binding site [ion binding]; metal-binding site 1639005050 AMP-binding enzyme; Region: AMP-binding; pfam00501 1639005051 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1639005052 acyl-activating enzyme (AAE) consensus motif; other site 1639005053 putative active site [active] 1639005054 putative AMP binding site [chemical binding]; other site 1639005055 putative CoA binding site [chemical binding]; other site 1639005056 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1639005057 trimer interface [polypeptide binding]; other site 1639005058 oxyanion hole (OAH) forming residues; other site 1639005059 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1639005060 substrate binding site [chemical binding]; other site 1639005061 oxyanion hole (OAH) forming residues; other site 1639005062 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1639005063 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1639005064 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1639005065 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 1639005066 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1639005067 dimer interface [polypeptide binding]; other site 1639005068 tetramer interface [polypeptide binding]; other site 1639005069 PYR/PP interface [polypeptide binding]; other site 1639005070 TPP binding site [chemical binding]; other site 1639005071 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1639005072 TPP-binding site; other site 1639005073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1639005074 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1639005075 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1639005076 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1639005077 UbiA prenyltransferase family; Region: UbiA; pfam01040 1639005078 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1639005079 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1639005080 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1639005081 FAD binding site [chemical binding]; other site 1639005082 cystathionine beta-lyase; Provisional; Region: PRK08064 1639005083 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1639005084 homodimer interface [polypeptide binding]; other site 1639005085 substrate-cofactor binding pocket; other site 1639005086 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639005087 catalytic residue [active] 1639005088 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1639005089 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1639005090 homodimer interface [polypeptide binding]; other site 1639005091 substrate-cofactor binding pocket; other site 1639005092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639005093 catalytic residue [active] 1639005094 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1639005095 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1639005096 THF binding site; other site 1639005097 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1639005098 substrate binding site [chemical binding]; other site 1639005099 THF binding site; other site 1639005100 zinc-binding site [ion binding]; other site 1639005101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639005102 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639005103 putative substrate translocation pore; other site 1639005104 ferric uptake regulator; Provisional; Region: fur; PRK09462 1639005105 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1639005106 metal binding site 2 [ion binding]; metal-binding site 1639005107 putative DNA binding helix; other site 1639005108 metal binding site 1 [ion binding]; metal-binding site 1639005109 dimer interface [polypeptide binding]; other site 1639005110 structural Zn2+ binding site [ion binding]; other site 1639005111 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1639005112 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1639005113 NAD binding site [chemical binding]; other site 1639005114 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1639005115 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1639005116 inhibitor-cofactor binding pocket; inhibition site 1639005117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639005118 catalytic residue [active] 1639005119 Predicted membrane protein [Function unknown]; Region: COG4129 1639005120 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1639005121 hypothetical protein; Provisional; Region: PRK13662 1639005122 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1639005123 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1639005124 putative NAD(P) binding site [chemical binding]; other site 1639005125 active site 1639005126 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1639005127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1639005128 minor groove reading motif; other site 1639005129 helix-hairpin-helix signature motif; other site 1639005130 substrate binding pocket [chemical binding]; other site 1639005131 active site 1639005132 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1639005133 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1639005134 DNA binding and oxoG recognition site [nucleotide binding] 1639005135 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1639005136 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1639005137 trimer interface [polypeptide binding]; other site 1639005138 active site 1639005139 WVELL protein; Region: WVELL; pfam14043 1639005140 recombination regulator RecX; Provisional; Region: recX; PRK14135 1639005141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639005142 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1639005143 NAD(P) binding site [chemical binding]; other site 1639005144 active site 1639005145 Predicted integral membrane protein [Function unknown]; Region: COG0392 1639005146 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1639005147 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1639005148 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 1639005149 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1639005150 Cation efflux family; Region: Cation_efflux; pfam01545 1639005151 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1639005152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1639005153 PAS fold; Region: PAS_4; pfam08448 1639005154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1639005155 putative active site [active] 1639005156 heme pocket [chemical binding]; other site 1639005157 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1639005158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1639005159 dimer interface [polypeptide binding]; other site 1639005160 putative CheW interface [polypeptide binding]; other site 1639005161 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1639005162 FosX, a fosfomycin resistance protein, catalyzes the addition of a water molecule to the C1 position of the antibiotic with inversion of configuration at C1; Region: FosX; cd08364 1639005163 dimer interface [polypeptide binding]; other site 1639005164 active site 1639005165 Mn binding site [ion binding]; other site 1639005166 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1639005167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639005168 S-adenosylmethionine binding site [chemical binding]; other site 1639005169 TRAM domain; Region: TRAM; cl01282 1639005170 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1639005171 OsmC-like protein; Region: OsmC; cl00767 1639005172 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1639005173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4840 1639005174 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1639005175 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1639005176 active site 1639005177 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1639005178 flavodoxin, short chain; Region: flav_short; TIGR01753 1639005179 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1639005180 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1639005181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639005182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639005183 putative substrate translocation pore; other site 1639005184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639005185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639005186 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639005187 nucleotide binding site [chemical binding]; other site 1639005188 MreB and similar proteins; Region: MreB_like; cd10225 1639005189 nucleotide binding site [chemical binding]; other site 1639005190 RodZ interaction site [polypeptide binding]; other site 1639005191 putative protofilament interaction site [polypeptide binding]; other site 1639005192 Mg binding site [ion binding]; other site 1639005193 Uncharacterized conserved protein [Function unknown]; Region: COG3589 1639005194 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 1639005195 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639005196 methionine cluster; other site 1639005197 active site 1639005198 phosphorylation site [posttranslational modification] 1639005199 metal binding site [ion binding]; metal-binding site 1639005200 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639005201 active site 1639005202 P-loop; other site 1639005203 phosphorylation site [posttranslational modification] 1639005204 PRD domain; Region: PRD; pfam00874 1639005205 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639005206 active pocket/dimerization site; other site 1639005207 active site 1639005208 phosphorylation site [posttranslational modification] 1639005209 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1639005210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639005211 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1639005212 Walker A motif; other site 1639005213 ATP binding site [chemical binding]; other site 1639005214 Walker B motif; other site 1639005215 arginine finger; other site 1639005216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639005217 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1639005218 ATP binding site [chemical binding]; other site 1639005219 putative Mg++ binding site [ion binding]; other site 1639005220 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639005221 nucleotide binding region [chemical binding]; other site 1639005222 ATP-binding site [chemical binding]; other site 1639005223 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1639005224 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1639005225 Walker A/P-loop; other site 1639005226 ATP binding site [chemical binding]; other site 1639005227 Q-loop/lid; other site 1639005228 ABC transporter signature motif; other site 1639005229 Walker B; other site 1639005230 D-loop; other site 1639005231 H-loop/switch region; other site 1639005232 Predicted transcriptional regulators [Transcription]; Region: COG1725 1639005233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639005234 DNA-binding site [nucleotide binding]; DNA binding site 1639005235 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639005236 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639005237 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639005238 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639005239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639005240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639005241 DNA binding site [nucleotide binding] 1639005242 domain linker motif; other site 1639005243 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639005244 dimerization interface [polypeptide binding]; other site 1639005245 ligand binding site [chemical binding]; other site 1639005246 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1639005247 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1639005248 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1639005249 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1639005250 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1639005251 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1639005252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639005253 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639005254 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639005255 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639005256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639005257 dimer interface [polypeptide binding]; other site 1639005258 conserved gate region; other site 1639005259 ABC-ATPase subunit interface; other site 1639005260 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1639005261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1639005262 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1639005263 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1639005264 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1639005265 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1639005266 active site 1639005267 FMN binding site [chemical binding]; other site 1639005268 substrate binding site [chemical binding]; other site 1639005269 3Fe-4S cluster binding site [ion binding]; other site 1639005270 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1639005271 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639005272 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 1639005273 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1639005274 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1639005275 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1639005276 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1639005277 dimer interface [polypeptide binding]; other site 1639005278 active site 1639005279 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1639005280 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639005281 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639005282 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1639005283 putative dimerization interface [polypeptide binding]; other site 1639005284 Predicted acetyltransferase [General function prediction only]; Region: COG3153 1639005285 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1639005286 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1639005287 substrate binding pocket [chemical binding]; other site 1639005288 membrane-bound complex binding site; other site 1639005289 hinge residues; other site 1639005290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639005291 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639005292 ABC transporter signature motif; other site 1639005293 Walker B; other site 1639005294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639005295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639005296 dimer interface [polypeptide binding]; other site 1639005297 conserved gate region; other site 1639005298 putative PBP binding loops; other site 1639005299 ABC-ATPase subunit interface; other site 1639005300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1639005301 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1639005302 dimer interface [polypeptide binding]; other site 1639005303 phosphorylation site [posttranslational modification] 1639005304 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639005305 ATP binding site [chemical binding]; other site 1639005306 Mg2+ binding site [ion binding]; other site 1639005307 G-X-G motif; other site 1639005308 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1639005309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1639005310 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1639005311 active site 1639005312 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1639005313 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1639005314 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1639005315 putative NAD(P) binding site [chemical binding]; other site 1639005316 active site 1639005317 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639005318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639005319 active site 1639005320 phosphorylation site [posttranslational modification] 1639005321 intermolecular recognition site; other site 1639005322 dimerization interface [polypeptide binding]; other site 1639005323 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639005324 DNA binding site [nucleotide binding] 1639005325 FtsX-like permease family; Region: FtsX; pfam02687 1639005326 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1639005327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639005328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639005329 Walker A/P-loop; other site 1639005330 ATP binding site [chemical binding]; other site 1639005331 Q-loop/lid; other site 1639005332 ABC transporter signature motif; other site 1639005333 Walker B; other site 1639005334 D-loop; other site 1639005335 H-loop/switch region; other site 1639005336 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1639005337 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1639005338 ADP binding site [chemical binding]; other site 1639005339 magnesium binding site [ion binding]; other site 1639005340 putative shikimate binding site; other site 1639005341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4884 1639005342 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1639005343 TRAM domain; Region: TRAM; pfam01938 1639005344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639005345 S-adenosylmethionine binding site [chemical binding]; other site 1639005346 putative lipid kinase; Reviewed; Region: PRK13337 1639005347 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1639005348 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1639005349 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1639005350 GatB domain; Region: GatB_Yqey; pfam02637 1639005351 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1639005352 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1639005353 Amidase; Region: Amidase; cl11426 1639005354 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1639005355 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 1639005356 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 1639005357 putative dimer interface [polypeptide binding]; other site 1639005358 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 1639005359 putative dimer interface [polypeptide binding]; other site 1639005360 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1639005361 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1639005362 nucleotide binding pocket [chemical binding]; other site 1639005363 K-X-D-G motif; other site 1639005364 catalytic site [active] 1639005365 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1639005366 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1639005367 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1639005368 Dimer interface [polypeptide binding]; other site 1639005369 BRCT sequence motif; other site 1639005370 Family description; Region: UvrD_C_2; pfam13538 1639005371 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1639005372 Part of AAA domain; Region: AAA_19; pfam13245 1639005373 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1639005374 PcrB family; Region: PcrB; pfam01884 1639005375 substrate binding site [chemical binding]; other site 1639005376 putative active site [active] 1639005377 dimer interface [polypeptide binding]; other site 1639005378 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1639005379 Na2 binding site [ion binding]; other site 1639005380 putative substrate binding site 1 [chemical binding]; other site 1639005381 Na binding site 1 [ion binding]; other site 1639005382 putative substrate binding site 2 [chemical binding]; other site 1639005383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1639005384 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1639005385 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1639005386 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1639005387 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1639005388 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1639005389 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1639005390 purine monophosphate binding site [chemical binding]; other site 1639005391 dimer interface [polypeptide binding]; other site 1639005392 putative catalytic residues [active] 1639005393 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1639005394 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1639005395 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1639005396 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1639005397 active site 1639005398 substrate binding site [chemical binding]; other site 1639005399 cosubstrate binding site; other site 1639005400 catalytic site [active] 1639005401 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1639005402 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1639005403 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1639005404 dimerization interface [polypeptide binding]; other site 1639005405 putative ATP binding site [chemical binding]; other site 1639005406 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1639005407 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1639005408 active site 1639005409 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1639005410 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1639005411 dimerization interface [polypeptide binding]; other site 1639005412 ATP binding site [chemical binding]; other site 1639005413 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1639005414 dimerization interface [polypeptide binding]; other site 1639005415 ATP binding site [chemical binding]; other site 1639005416 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1639005417 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1639005418 putative active site [active] 1639005419 catalytic triad [active] 1639005420 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1639005421 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1639005422 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1639005423 ATP binding site [chemical binding]; other site 1639005424 active site 1639005425 substrate binding site [chemical binding]; other site 1639005426 adenylosuccinate lyase; Provisional; Region: PRK07492 1639005427 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1639005428 tetramer interface [polypeptide binding]; other site 1639005429 active site 1639005430 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1639005431 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1639005432 NAD binding site [chemical binding]; other site 1639005433 ATP-grasp domain; Region: ATP-grasp; pfam02222 1639005434 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1639005435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 1639005436 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1639005437 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1639005438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639005439 Zn2+ binding site [ion binding]; other site 1639005440 Mg2+ binding site [ion binding]; other site 1639005441 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1639005442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639005443 Walker A/P-loop; other site 1639005444 ATP binding site [chemical binding]; other site 1639005445 Q-loop/lid; other site 1639005446 ABC transporter signature motif; other site 1639005447 Walker B; other site 1639005448 D-loop; other site 1639005449 H-loop/switch region; other site 1639005450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1639005451 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1639005452 active site 1639005453 putative catalytic site [active] 1639005454 DNA binding site [nucleotide binding] 1639005455 putative phosphate binding site [ion binding]; other site 1639005456 metal binding site A [ion binding]; metal-binding site 1639005457 metal binding site B [ion binding]; metal-binding site 1639005458 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1639005459 putative metal binding site [ion binding]; other site 1639005460 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1639005461 23S rRNA binding site [nucleotide binding]; other site 1639005462 L21 binding site [polypeptide binding]; other site 1639005463 L13 binding site [polypeptide binding]; other site 1639005464 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1639005465 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1639005466 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1639005467 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1639005468 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639005469 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1639005470 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1639005471 Substrate binding site [chemical binding]; other site 1639005472 Leucine rich repeat; Region: LRR_8; pfam13855 1639005473 LRR adjacent; Region: LRR_adjacent; pfam08191 1639005474 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1639005475 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1639005476 DNA binding residues [nucleotide binding] 1639005477 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1639005478 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1639005479 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639005480 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1639005481 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1639005482 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1639005483 RimM N-terminal domain; Region: RimM; pfam01782 1639005484 PRC-barrel domain; Region: PRC; pfam05239 1639005485 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1639005486 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 1639005487 Peptidase C26; Region: Peptidase_C26; pfam07722 1639005488 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1639005489 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1639005490 KH domain; Region: KH_4; pfam13083 1639005491 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1639005492 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1639005493 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1639005494 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1639005495 signal recognition particle protein; Provisional; Region: PRK10867 1639005496 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1639005497 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1639005498 P loop; other site 1639005499 GTP binding site [chemical binding]; other site 1639005500 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1639005501 putative DNA-binding protein; Validated; Region: PRK00118 1639005502 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1639005503 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1639005504 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1639005505 P loop; other site 1639005506 GTP binding site [chemical binding]; other site 1639005507 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1639005508 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1639005509 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1639005510 Walker A/P-loop; other site 1639005511 ATP binding site [chemical binding]; other site 1639005512 Q-loop/lid; other site 1639005513 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1639005514 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1639005515 ABC transporter signature motif; other site 1639005516 Walker B; other site 1639005517 D-loop; other site 1639005518 H-loop/switch region; other site 1639005519 ribonuclease III; Reviewed; Region: rnc; PRK00102 1639005520 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1639005521 dimerization interface [polypeptide binding]; other site 1639005522 active site 1639005523 metal binding site [ion binding]; metal-binding site 1639005524 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1639005525 dsRNA binding site [nucleotide binding]; other site 1639005526 acyl carrier protein; Provisional; Region: acpP; PRK00982 1639005527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1639005528 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1639005529 NAD(P) binding site [chemical binding]; other site 1639005530 homotetramer interface [polypeptide binding]; other site 1639005531 homodimer interface [polypeptide binding]; other site 1639005532 active site 1639005533 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1639005534 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1639005535 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 1639005536 putative phosphate acyltransferase; Provisional; Region: PRK05331 1639005537 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1639005538 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 1639005539 active site 2 [active] 1639005540 active site 1 [active] 1639005541 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1639005542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1639005543 ATP-binding site [chemical binding]; other site 1639005544 Y-family of DNA polymerases; Region: PolY; cl12025 1639005545 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1639005546 generic binding surface II; other site 1639005547 ssDNA binding site; other site 1639005548 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1639005549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639005550 ATP binding site [chemical binding]; other site 1639005551 putative Mg++ binding site [ion binding]; other site 1639005552 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1639005553 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1639005554 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1639005555 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1639005556 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1639005557 putative L-serine binding site [chemical binding]; other site 1639005558 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1639005559 DAK2 domain; Region: Dak2; pfam02734 1639005560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1639005561 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1639005562 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1639005563 Thiamine pyrophosphokinase; Region: TPK; cd07995 1639005564 active site 1639005565 dimerization interface [polypeptide binding]; other site 1639005566 thiamine binding site [chemical binding]; other site 1639005567 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1639005568 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1639005569 substrate binding site [chemical binding]; other site 1639005570 hexamer interface [polypeptide binding]; other site 1639005571 metal binding site [ion binding]; metal-binding site 1639005572 GTPase RsgA; Reviewed; Region: PRK00098 1639005573 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1639005574 RNA binding site [nucleotide binding]; other site 1639005575 homodimer interface [polypeptide binding]; other site 1639005576 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1639005577 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1639005578 GTP/Mg2+ binding site [chemical binding]; other site 1639005579 G4 box; other site 1639005580 G1 box; other site 1639005581 Switch I region; other site 1639005582 G2 box; other site 1639005583 G3 box; other site 1639005584 Switch II region; other site 1639005585 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1639005586 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1639005587 active site 1639005588 ATP binding site [chemical binding]; other site 1639005589 substrate binding site [chemical binding]; other site 1639005590 activation loop (A-loop); other site 1639005591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1639005592 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1639005593 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1639005594 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1639005595 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1639005596 Protein phosphatase 2C; Region: PP2C; pfam00481 1639005597 active site 1639005598 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1639005599 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1639005600 putative RNA binding site [nucleotide binding]; other site 1639005601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639005602 S-adenosylmethionine binding site [chemical binding]; other site 1639005603 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1639005604 substrate binding site [chemical binding]; other site 1639005605 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1639005606 putative active site [active] 1639005607 substrate binding site [chemical binding]; other site 1639005608 putative cosubstrate binding site; other site 1639005609 catalytic site [active] 1639005610 primosome assembly protein PriA; Validated; Region: PRK05580 1639005611 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1639005612 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639005613 ATP binding site [chemical binding]; other site 1639005614 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1639005615 Flavoprotein; Region: Flavoprotein; pfam02441 1639005616 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1639005617 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1639005618 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1639005619 catalytic site [active] 1639005620 G-X2-G-X-G-K; other site 1639005621 Uncharacterized stress-induced protein [Function unknown]; Region: COG1561 1639005622 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1639005623 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1639005624 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1639005625 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1639005626 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 1639005627 putative NAD(P) binding site [chemical binding]; other site 1639005628 homodimer interface [polypeptide binding]; other site 1639005629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639005630 active site 1639005631 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1639005632 active site 1639005633 dimer interface [polypeptide binding]; other site 1639005634 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1639005635 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1639005636 heterodimer interface [polypeptide binding]; other site 1639005637 active site 1639005638 FMN binding site [chemical binding]; other site 1639005639 homodimer interface [polypeptide binding]; other site 1639005640 substrate binding site [chemical binding]; other site 1639005641 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1639005642 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1639005643 FAD binding pocket [chemical binding]; other site 1639005644 FAD binding motif [chemical binding]; other site 1639005645 phosphate binding motif [ion binding]; other site 1639005646 beta-alpha-beta structure motif; other site 1639005647 NAD binding pocket [chemical binding]; other site 1639005648 Iron coordination center [ion binding]; other site 1639005649 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1639005650 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1639005651 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1639005652 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1639005653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1639005654 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1639005655 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1639005656 IMP binding site; other site 1639005657 dimer interface [polypeptide binding]; other site 1639005658 interdomain contacts; other site 1639005659 partial ornithine binding site; other site 1639005660 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1639005661 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1639005662 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1639005663 catalytic site [active] 1639005664 subunit interface [polypeptide binding]; other site 1639005665 dihydroorotase; Validated; Region: pyrC; PRK09357 1639005666 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1639005667 active site 1639005668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1639005669 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1639005670 uracil transporter; Provisional; Region: PRK10720 1639005671 uracil transporter; Provisional; Region: PRK10720 1639005672 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1639005673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639005674 active site 1639005675 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1639005676 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639005677 RNA binding surface [nucleotide binding]; other site 1639005678 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1639005679 active site 1639005680 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1639005681 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1639005682 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1639005683 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1639005684 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1639005685 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639005686 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1639005687 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1639005688 metal binding site [ion binding]; metal-binding site 1639005689 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1639005690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639005691 ABC-ATPase subunit interface; other site 1639005692 dimer interface [polypeptide binding]; other site 1639005693 putative PBP binding regions; other site 1639005694 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1639005695 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1639005696 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639005697 MarR family; Region: MarR; pfam01047 1639005698 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1639005699 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1639005700 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1639005701 protein binding site [polypeptide binding]; other site 1639005702 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1639005703 Catalytic dyad [active] 1639005704 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1639005705 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1639005706 metal-binding site [ion binding] 1639005707 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639005708 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1639005709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639005710 motif II; other site 1639005711 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1639005712 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1639005713 metal-binding site [ion binding] 1639005714 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639005715 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 1639005716 putative homodimer interface [polypeptide binding]; other site 1639005717 putative homotetramer interface [polypeptide binding]; other site 1639005718 putative allosteric switch controlling residues; other site 1639005719 putative metal binding site [ion binding]; other site 1639005720 putative homodimer-homodimer interface [polypeptide binding]; other site 1639005721 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1639005722 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1639005723 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1639005724 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1639005725 hypothetical protein; Provisional; Region: PRK13672 1639005726 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639005727 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639005728 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1639005729 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1639005730 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1639005731 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 1639005732 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 1639005733 active site 1639005734 catalytic triad [active] 1639005735 oxyanion hole [active] 1639005736 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1639005737 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1639005738 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1639005739 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1639005740 HTH domain; Region: HTH_11; pfam08279 1639005741 FOG: CBS domain [General function prediction only]; Region: COG0517 1639005742 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 1639005743 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1639005744 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1639005745 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1639005746 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1639005747 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1639005748 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1639005749 active site 1639005750 Predicted membrane protein [Function unknown]; Region: COG4129 1639005751 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1639005752 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1639005753 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1639005754 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1639005755 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1639005756 active site 1639005757 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1639005758 substrate binding site [chemical binding]; other site 1639005759 metal binding site [ion binding]; metal-binding site 1639005760 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1639005761 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1639005762 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1639005763 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1639005764 folate binding site [chemical binding]; other site 1639005765 NADP+ binding site [chemical binding]; other site 1639005766 thymidylate synthase; Region: thym_sym; TIGR03284 1639005767 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1639005768 dimerization interface [polypeptide binding]; other site 1639005769 active site 1639005770 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1639005771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639005772 Walker A/P-loop; other site 1639005773 ATP binding site [chemical binding]; other site 1639005774 Q-loop/lid; other site 1639005775 ABC transporter signature motif; other site 1639005776 Walker B; other site 1639005777 D-loop; other site 1639005778 H-loop/switch region; other site 1639005779 ABC transporter; Region: ABC_tran_2; pfam12848 1639005780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639005781 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639005782 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1639005783 Potassium binding sites [ion binding]; other site 1639005784 Cesium cation binding sites [ion binding]; other site 1639005785 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1639005786 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1639005787 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1639005788 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1639005789 DNA-binding site [nucleotide binding]; DNA binding site 1639005790 RNA-binding motif; other site 1639005791 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1639005792 RNA/DNA hybrid binding site [nucleotide binding]; other site 1639005793 active site 1639005794 5'-3' exonuclease; Region: 53EXOc; smart00475 1639005795 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1639005796 active site 1639005797 metal binding site 1 [ion binding]; metal-binding site 1639005798 putative 5' ssDNA interaction site; other site 1639005799 metal binding site 3; metal-binding site 1639005800 metal binding site 2 [ion binding]; metal-binding site 1639005801 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1639005802 putative DNA binding site [nucleotide binding]; other site 1639005803 putative metal binding site [ion binding]; other site 1639005804 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1639005805 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1639005806 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1639005807 putative active site [active] 1639005808 xanthine permease; Region: pbuX; TIGR03173 1639005809 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639005810 active site 1639005811 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1639005812 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1639005813 active site 1639005814 Zn binding site [ion binding]; other site 1639005815 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1639005816 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1639005817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1639005818 hypothetical protein; Provisional; Region: PRK13660 1639005819 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 1639005820 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1639005821 Transglycosylase; Region: Transgly; pfam00912 1639005822 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1639005823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1639005824 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1639005825 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1639005826 minor groove reading motif; other site 1639005827 helix-hairpin-helix signature motif; other site 1639005828 substrate binding pocket [chemical binding]; other site 1639005829 active site 1639005830 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1639005831 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1639005832 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1639005833 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1639005834 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1639005835 putative dimer interface [polypeptide binding]; other site 1639005836 putative anticodon binding site; other site 1639005837 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1639005838 homodimer interface [polypeptide binding]; other site 1639005839 motif 1; other site 1639005840 motif 2; other site 1639005841 active site 1639005842 motif 3; other site 1639005843 aspartate aminotransferase; Provisional; Region: PRK05764 1639005844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639005845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639005846 homodimer interface [polypeptide binding]; other site 1639005847 catalytic residue [active] 1639005848 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1639005849 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1639005850 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1639005851 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1639005852 active site 1639005853 catalytic site [active] 1639005854 substrate binding site [chemical binding]; other site 1639005855 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1639005856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1639005857 putative Mg++ binding site [ion binding]; other site 1639005858 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1639005859 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1639005860 tetramerization interface [polypeptide binding]; other site 1639005861 active site 1639005862 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1639005863 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1639005864 active site 1639005865 ATP-binding site [chemical binding]; other site 1639005866 pantoate-binding site; other site 1639005867 HXXH motif; other site 1639005868 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1639005869 active site 1639005870 oligomerization interface [polypeptide binding]; other site 1639005871 metal binding site [ion binding]; metal-binding site 1639005872 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639005873 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1639005874 catalytic residues [active] 1639005875 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1639005876 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1639005877 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1639005878 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1639005879 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1639005880 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1639005881 active site 1639005882 NTP binding site [chemical binding]; other site 1639005883 metal binding triad [ion binding]; metal-binding site 1639005884 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1639005885 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1639005886 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1639005887 active site 1639005888 dimer interfaces [polypeptide binding]; other site 1639005889 catalytic residues [active] 1639005890 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1639005891 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1639005892 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1639005893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1639005894 homodimer interface [polypeptide binding]; other site 1639005895 metal binding site [ion binding]; metal-binding site 1639005896 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1639005897 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639005898 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639005899 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1639005900 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1639005901 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1639005902 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1639005903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1639005904 metal binding site [ion binding]; metal-binding site 1639005905 active site 1639005906 I-site; other site 1639005907 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1639005908 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1639005909 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1639005910 metal binding site [ion binding]; metal-binding site 1639005911 active site 1639005912 I-site; other site 1639005913 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1639005914 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1639005915 malate dehydrogenase; Provisional; Region: PRK13529 1639005916 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1639005917 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1639005918 NAD(P) binding pocket [chemical binding]; other site 1639005919 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1639005920 Beta-lactamase; Region: Beta-lactamase; pfam00144 1639005921 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 1639005922 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1639005923 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1639005924 HI0933-like protein; Region: HI0933_like; pfam03486 1639005925 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639005926 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1639005927 Predicted membrane protein [Function unknown]; Region: COG4347 1639005928 hypothetical protein; Provisional; Region: PRK03636 1639005929 UPF0302 domain; Region: UPF0302; pfam08864 1639005930 IDEAL domain; Region: IDEAL; pfam08858 1639005931 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1639005932 binding surface 1639005933 TPR motif; other site 1639005934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639005935 binding surface 1639005936 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1639005937 TPR motif; other site 1639005938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1639005939 binding surface 1639005940 TPR motif; other site 1639005941 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1639005942 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1639005943 prephenate dehydrogenase; Validated; Region: PRK06545 1639005944 prephenate dehydrogenase; Validated; Region: PRK08507 1639005945 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1639005946 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1639005947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639005948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639005949 homodimer interface [polypeptide binding]; other site 1639005950 catalytic residue [active] 1639005951 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1639005952 homotrimer interaction site [polypeptide binding]; other site 1639005953 active site 1639005954 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1639005955 metal binding site [ion binding]; metal-binding site 1639005956 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1639005957 active site 1639005958 NAD binding site [chemical binding]; other site 1639005959 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1639005960 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1639005961 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1639005962 Tetramer interface [polypeptide binding]; other site 1639005963 active site 1639005964 FMN-binding site [chemical binding]; other site 1639005965 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1639005966 active site 1639005967 multimer interface [polypeptide binding]; other site 1639005968 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1639005969 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1639005970 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1639005971 substrate binding pocket [chemical binding]; other site 1639005972 chain length determination region; other site 1639005973 catalytic residues [active] 1639005974 aspartate-rich region 1; other site 1639005975 substrate-Mg2+ binding site; other site 1639005976 active site lid residues [active] 1639005977 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1639005978 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639005979 S-adenosylmethionine binding site [chemical binding]; other site 1639005980 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1639005981 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1639005982 homodecamer interface [polypeptide binding]; other site 1639005983 GTP cyclohydrolase I; Provisional; Region: PLN03044 1639005984 active site 1639005985 putative catalytic site residues [active] 1639005986 zinc binding site [ion binding]; other site 1639005987 GTP-CH-I/GFRP interaction surface; other site 1639005988 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1639005989 IHF dimer interface [polypeptide binding]; other site 1639005990 IHF - DNA interface [nucleotide binding]; other site 1639005991 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1639005992 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1639005993 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1639005994 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1639005995 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1639005996 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1639005997 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1639005998 G1 box; other site 1639005999 GTP/Mg2+ binding site [chemical binding]; other site 1639006000 Switch I region; other site 1639006001 G2 box; other site 1639006002 Switch II region; other site 1639006003 G3 box; other site 1639006004 G4 box; other site 1639006005 G5 box; other site 1639006006 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1639006007 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1639006008 G1 box; other site 1639006009 GTP/Mg2+ binding site [chemical binding]; other site 1639006010 Switch I region; other site 1639006011 G2 box; other site 1639006012 G3 box; other site 1639006013 Switch II region; other site 1639006014 G4 box; other site 1639006015 G5 box; other site 1639006016 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1639006017 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1639006018 RNA binding site [nucleotide binding]; other site 1639006019 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1639006020 RNA binding site [nucleotide binding]; other site 1639006021 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1639006022 RNA binding site [nucleotide binding]; other site 1639006023 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1639006024 RNA binding site [nucleotide binding]; other site 1639006025 cytidylate kinase; Provisional; Region: cmk; PRK00023 1639006026 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1639006027 CMP-binding site; other site 1639006028 The sites determining sugar specificity; other site 1639006029 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1639006030 active site 1639006031 homotetramer interface [polypeptide binding]; other site 1639006032 homodimer interface [polypeptide binding]; other site 1639006033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1639006034 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1639006035 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1639006036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639006037 ATP binding site [chemical binding]; other site 1639006038 putative Mg++ binding site [ion binding]; other site 1639006039 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639006040 nucleotide binding region [chemical binding]; other site 1639006041 ATP-binding site [chemical binding]; other site 1639006042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 1639006043 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1639006044 Predicted membrane protein [Function unknown]; Region: COG3601 1639006045 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1639006046 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1639006047 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639006048 dimerization interface [polypeptide binding]; other site 1639006049 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1639006050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639006051 dimer interface [polypeptide binding]; other site 1639006052 phosphorylation site [posttranslational modification] 1639006053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639006054 ATP binding site [chemical binding]; other site 1639006055 Mg2+ binding site [ion binding]; other site 1639006056 G-X-G motif; other site 1639006057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639006058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639006059 active site 1639006060 phosphorylation site [posttranslational modification] 1639006061 intermolecular recognition site; other site 1639006062 dimerization interface [polypeptide binding]; other site 1639006063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639006064 DNA binding site [nucleotide binding] 1639006065 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1639006066 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1639006067 RNA binding surface [nucleotide binding]; other site 1639006068 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1639006069 active site 1639006070 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1639006071 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1639006072 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1639006073 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1639006074 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1639006075 catalytic residue [active] 1639006076 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1639006077 phosphopentomutase; Provisional; Region: PRK05362 1639006078 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1639006079 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1639006080 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1639006081 active site 1639006082 Int/Topo IB signature motif; other site 1639006083 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1639006084 metal binding site 2 [ion binding]; metal-binding site 1639006085 putative DNA binding helix; other site 1639006086 metal binding site 1 [ion binding]; metal-binding site 1639006087 dimer interface [polypeptide binding]; other site 1639006088 structural Zn2+ binding site [ion binding]; other site 1639006089 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1639006090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639006091 ABC-ATPase subunit interface; other site 1639006092 dimer interface [polypeptide binding]; other site 1639006093 putative PBP binding regions; other site 1639006094 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639006095 dimer interface [polypeptide binding]; other site 1639006096 putative PBP binding regions; other site 1639006097 ABC-ATPase subunit interface; other site 1639006098 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1639006099 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1639006100 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1639006101 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1639006102 putative ligand binding residues [chemical binding]; other site 1639006103 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1639006104 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1639006105 Walker A/P-loop; other site 1639006106 ATP binding site [chemical binding]; other site 1639006107 Q-loop/lid; other site 1639006108 ABC transporter signature motif; other site 1639006109 Walker B; other site 1639006110 D-loop; other site 1639006111 H-loop/switch region; other site 1639006112 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1639006113 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639006114 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639006115 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639006116 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1639006117 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1639006118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1639006119 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1639006120 Walker A/P-loop; other site 1639006121 ATP binding site [chemical binding]; other site 1639006122 Q-loop/lid; other site 1639006123 ABC transporter signature motif; other site 1639006124 Walker B; other site 1639006125 D-loop; other site 1639006126 H-loop/switch region; other site 1639006127 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1639006128 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1639006129 dimer interface [polypeptide binding]; other site 1639006130 ADP-ribose binding site [chemical binding]; other site 1639006131 active site 1639006132 nudix motif; other site 1639006133 metal binding site [ion binding]; metal-binding site 1639006134 5-bromo-4-chloroindolyl phosphate hydrolysis protein [General function prediction only]; Region: XpaC; COG4915 1639006135 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1639006136 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1639006137 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1639006138 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1639006139 active site 1639006140 intersubunit interface [polypeptide binding]; other site 1639006141 catalytic residue [active] 1639006142 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1639006143 active site 1639006144 substrate binding pocket [chemical binding]; other site 1639006145 homodimer interaction site [polypeptide binding]; other site 1639006146 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 1639006147 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1639006148 active site 1639006149 P-loop; other site 1639006150 phosphorylation site [posttranslational modification] 1639006151 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639006152 active site 1639006153 phosphorylation site [posttranslational modification] 1639006154 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639006155 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639006156 DNA-binding site [nucleotide binding]; DNA binding site 1639006157 UTRA domain; Region: UTRA; pfam07702 1639006158 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1639006159 active site 1639006160 DNA polymerase IV; Validated; Region: PRK02406 1639006161 DNA binding site [nucleotide binding] 1639006162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639006163 active site 1639006164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639006165 ribonuclease Z; Region: RNase_Z; TIGR02651 1639006166 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1639006167 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1639006168 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1639006169 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 1639006170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1639006171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639006172 Coenzyme A binding pocket [chemical binding]; other site 1639006173 Dehydratase family; Region: ILVD_EDD; cl00340 1639006174 Dehydratase family; Region: ILVD_EDD; cl00340 1639006175 Dehydratase family; Region: ILVD_EDD; cl00340 1639006176 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1639006177 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1639006178 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1639006179 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1639006180 TPP-binding site [chemical binding]; other site 1639006181 dimer interface [polypeptide binding]; other site 1639006182 acetolactate synthase, small subunit; Region: acolac_sm; TIGR00119 1639006183 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1639006184 putative valine binding site [chemical binding]; other site 1639006185 dimer interface [polypeptide binding]; other site 1639006186 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1639006187 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1639006188 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1639006189 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1639006190 2-isopropylmalate synthase; Validated; Region: PRK00915 1639006191 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1639006192 active site 1639006193 catalytic residues [active] 1639006194 metal binding site [ion binding]; metal-binding site 1639006195 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1639006196 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1639006197 tartrate dehydrogenase; Region: TTC; TIGR02089 1639006198 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1639006199 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1639006200 substrate binding site [chemical binding]; other site 1639006201 ligand binding site [chemical binding]; other site 1639006202 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1639006203 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1639006204 substrate binding site [chemical binding]; other site 1639006205 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1639006206 tetramer interface [polypeptide binding]; other site 1639006207 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1639006208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639006209 catalytic residue [active] 1639006210 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1639006211 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1639006212 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 1639006213 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1639006214 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1639006215 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1639006216 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639006217 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639006218 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639006219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639006220 DNA binding site [nucleotide binding] 1639006221 domain linker motif; other site 1639006222 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1639006223 dimerization interface [polypeptide binding]; other site 1639006224 ligand binding site [chemical binding]; other site 1639006225 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1639006226 intersubunit interface [polypeptide binding]; other site 1639006227 active site 1639006228 catalytic residue [active] 1639006229 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639006230 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1639006231 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1639006232 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1639006233 active pocket/dimerization site; other site 1639006234 active site 1639006235 phosphorylation site [posttranslational modification] 1639006236 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1639006237 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1639006238 putative active site [active] 1639006239 SIS domain; Region: SIS; pfam01380 1639006240 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1639006241 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1639006242 dimer interface [polypeptide binding]; other site 1639006243 active site 1639006244 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1639006245 dimer interface [polypeptide binding]; other site 1639006246 active site 1639006247 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1639006248 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1639006249 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1639006250 active site 1639006251 phosphorylation site [posttranslational modification] 1639006252 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639006253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639006254 DNA-binding site [nucleotide binding]; DNA binding site 1639006255 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639006256 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639006257 UTRA domain; Region: UTRA; pfam07702 1639006258 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639006259 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639006260 DNA-binding site [nucleotide binding]; DNA binding site 1639006261 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1639006262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639006263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639006264 catalytic tetrad [active] 1639006265 acetolactate synthase; Reviewed; Region: PRK08617 1639006266 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1639006267 PYR/PP interface [polypeptide binding]; other site 1639006268 dimer interface [polypeptide binding]; other site 1639006269 TPP binding site [chemical binding]; other site 1639006270 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1639006271 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1639006272 TPP-binding site [chemical binding]; other site 1639006273 dimer interface [polypeptide binding]; other site 1639006274 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639006275 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1639006276 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1639006277 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639006278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639006279 dimer interface [polypeptide binding]; other site 1639006280 conserved gate region; other site 1639006281 ABC-ATPase subunit interface; other site 1639006282 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1639006283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639006284 dimer interface [polypeptide binding]; other site 1639006285 conserved gate region; other site 1639006286 ABC-ATPase subunit interface; other site 1639006287 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1639006288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639006289 active site 1639006290 phosphorylation site [posttranslational modification] 1639006291 intermolecular recognition site; other site 1639006292 dimerization interface [polypeptide binding]; other site 1639006293 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1639006294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639006295 dimerization interface [polypeptide binding]; other site 1639006296 Histidine kinase; Region: His_kinase; pfam06580 1639006297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639006298 ATP binding site [chemical binding]; other site 1639006299 Mg2+ binding site [ion binding]; other site 1639006300 G-X-G motif; other site 1639006301 Predicted integral membrane protein [Function unknown]; Region: COG5578 1639006302 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1639006303 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1639006304 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639006305 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1639006306 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1639006307 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639006308 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639006309 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1639006310 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1639006311 DNA-binding site [nucleotide binding]; DNA binding site 1639006312 RNA-binding motif; other site 1639006313 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1639006314 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1639006315 active site 1639006316 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1639006317 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1639006318 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1639006319 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1639006320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639006321 active site 1639006322 KMSKS motif; other site 1639006323 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1639006324 tRNA binding surface [nucleotide binding]; other site 1639006325 anticodon binding site; other site 1639006326 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1639006327 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1639006328 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639006329 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1639006330 HIGH motif; other site 1639006331 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1639006332 DivIVA protein; Region: DivIVA; pfam05103 1639006333 DivIVA domain; Region: DivI1A_domain; TIGR03544 1639006334 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1639006335 HTH domain; Region: HTH_11; pfam08279 1639006336 3H domain; Region: 3H; pfam02829 1639006337 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639006338 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639006339 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639006340 catalytic residue [active] 1639006341 L-aspartate oxidase; Provisional; Region: PRK06175 1639006342 L-aspartate oxidase; Provisional; Region: PRK06175 1639006343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1639006344 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1639006345 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1639006346 active site 1639006347 Quinolinate synthetase A protein; Region: NadA; cl00420 1639006348 Quinolinate synthetase A protein; Region: NadA; cl00420 1639006349 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1639006350 YGGT family; Region: YGGT; pfam02325 1639006351 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1639006352 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1639006353 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1639006354 catalytic residue [active] 1639006355 cell division protein FtsZ; Validated; Region: PRK09330 1639006356 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1639006357 nucleotide binding site [chemical binding]; other site 1639006358 SulA interaction site; other site 1639006359 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1639006360 Cell division protein FtsA; Region: FtsA; smart00842 1639006361 Cell division protein FtsA; Region: FtsA; pfam14450 1639006362 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1639006363 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1639006364 Cell division protein FtsQ; Region: FtsQ; pfam03799 1639006365 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1639006366 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1639006367 active site 1639006368 homodimer interface [polypeptide binding]; other site 1639006369 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1639006370 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1639006371 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1639006372 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1639006373 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1639006374 Mg++ binding site [ion binding]; other site 1639006375 putative catalytic motif [active] 1639006376 putative substrate binding site [chemical binding]; other site 1639006377 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1639006378 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1639006379 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1639006380 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1639006381 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1639006382 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1639006383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1639006384 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1639006385 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1639006386 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1639006387 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1639006388 MraW methylase family; Region: Methyltransf_5; pfam01795 1639006389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1639006390 MraZ protein; Region: MraZ; pfam02381 1639006391 MraZ protein; Region: MraZ; pfam02381 1639006392 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639006393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639006394 putative substrate translocation pore; other site 1639006395 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1639006396 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1639006397 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1639006398 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1639006399 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1639006400 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1639006401 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1639006402 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1639006403 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1639006404 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1639006405 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1639006406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639006407 Walker A/P-loop; other site 1639006408 ATP binding site [chemical binding]; other site 1639006409 Q-loop/lid; other site 1639006410 ABC transporter signature motif; other site 1639006411 Walker B; other site 1639006412 D-loop; other site 1639006413 H-loop/switch region; other site 1639006414 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1639006415 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1639006416 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 1639006417 protein binding site [polypeptide binding]; other site 1639006418 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1639006419 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1639006420 active site 1639006421 (T/H)XGH motif; other site 1639006422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1639006423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1639006424 hypothetical protein; Provisional; Region: PRK02886 1639006425 Regulatory protein involved in competence development and sporulation [Replication, recombination and repair; Signal transduction mechanisms]; Region: COG3679 1639006426 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1639006427 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1639006428 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1639006429 UbiA prenyltransferase family; Region: UbiA; pfam01040 1639006430 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1639006431 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1639006432 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1639006433 Ion transport protein; Region: Ion_trans; pfam00520 1639006434 Ion channel; Region: Ion_trans_2; pfam07885 1639006435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1639006436 MOSC domain; Region: MOSC; pfam03473 1639006437 3-alpha domain; Region: 3-alpha; pfam03475 1639006438 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1639006439 Uncharacterized protein, homolog of Cu resistance protein CopC [General function prediction only]; Region: CopC; COG2372 1639006440 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1639006441 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13953 1639006442 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1639006443 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1639006444 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1639006445 ring oligomerisation interface [polypeptide binding]; other site 1639006446 ATP/Mg binding site [chemical binding]; other site 1639006447 stacking interactions; other site 1639006448 hinge regions; other site 1639006449 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1639006450 oligomerisation interface [polypeptide binding]; other site 1639006451 mobile loop; other site 1639006452 roof hairpin; other site 1639006453 CAAX protease self-immunity; Region: Abi; pfam02517 1639006454 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1639006455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639006456 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639006457 ABC transporter; Region: ABC_tran_2; pfam12848 1639006458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1639006459 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1639006460 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1639006461 UGMP family protein; Validated; Region: PRK09604 1639006462 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1639006463 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1639006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639006465 Coenzyme A binding pocket [chemical binding]; other site 1639006466 Glycoprotease family; Region: Peptidase_M22; pfam00814 1639006467 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1639006468 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1639006469 camphor resistance protein CrcB; Provisional; Region: PRK14231 1639006470 Uncharacterized conserved protein [Function unknown]; Region: COG4832 1639006471 Phosphotransferase enzyme family; Region: APH; pfam01636 1639006472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1639006473 active site 1639006474 substrate binding site [chemical binding]; other site 1639006475 ATP binding site [chemical binding]; other site 1639006476 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006477 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006478 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006479 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639006480 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639006481 non-specific DNA binding site [nucleotide binding]; other site 1639006482 salt bridge; other site 1639006483 sequence-specific DNA binding site [nucleotide binding]; other site 1639006484 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639006485 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1639006486 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639006487 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1639006488 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1639006489 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1639006490 argininosuccinate lyase; Provisional; Region: PRK00855 1639006491 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1639006492 active sites [active] 1639006493 tetramer interface [polypeptide binding]; other site 1639006494 BCCT family transporter; Region: BCCT; pfam02028 1639006495 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1639006496 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1639006497 putative substrate binding site [chemical binding]; other site 1639006498 putative ATP binding site [chemical binding]; other site 1639006499 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1639006500 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1639006501 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1639006502 active site 1639006503 P-loop; other site 1639006504 phosphorylation site [posttranslational modification] 1639006505 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639006506 active site 1639006507 phosphorylation site [posttranslational modification] 1639006508 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639006509 PRD domain; Region: PRD; pfam00874 1639006510 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639006511 active site 1639006512 P-loop; other site 1639006513 phosphorylation site [posttranslational modification] 1639006514 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 1639006515 active site 1639006516 phosphorylation site [posttranslational modification] 1639006517 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1639006518 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639006519 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639006520 homodimer interface [polypeptide binding]; other site 1639006521 catalytic residue [active] 1639006522 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639006523 phosphate binding site [ion binding]; other site 1639006524 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1639006525 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1639006526 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1639006527 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1639006528 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1639006529 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1639006530 G1 box; other site 1639006531 GTP/Mg2+ binding site [chemical binding]; other site 1639006532 Switch I region; other site 1639006533 G2 box; other site 1639006534 G3 box; other site 1639006535 Switch II region; other site 1639006536 G4 box; other site 1639006537 G5 box; other site 1639006538 Nucleoside recognition; Region: Gate; pfam07670 1639006539 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1639006540 Nucleoside recognition; Region: Gate; pfam07670 1639006541 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639006542 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1639006543 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639006544 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639006545 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639006546 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1639006547 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1639006548 active site 1639006549 dimer interface [polypeptide binding]; other site 1639006550 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1639006551 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1639006552 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1639006553 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1639006554 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1639006555 dimer interface [polypeptide binding]; other site 1639006556 FMN binding site [chemical binding]; other site 1639006557 Helix-turn-helix domain; Region: HTH_17; pfam12728 1639006558 putative heme peroxidase; Provisional; Region: PRK12276 1639006559 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639006560 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639006561 Walker A/P-loop; other site 1639006562 ATP binding site [chemical binding]; other site 1639006563 Q-loop/lid; other site 1639006564 ABC transporter signature motif; other site 1639006565 Walker B; other site 1639006566 D-loop; other site 1639006567 H-loop/switch region; other site 1639006568 FtsX-like permease family; Region: FtsX; pfam02687 1639006569 FtsX-like permease family; Region: FtsX; pfam02687 1639006570 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639006571 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1639006572 Coenzyme A binding pocket [chemical binding]; other site 1639006573 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1639006574 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1639006575 active site 1639006576 substrate binding site [chemical binding]; other site 1639006577 metal binding site [ion binding]; metal-binding site 1639006578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1639006579 YbbR-like protein; Region: YbbR; pfam07949 1639006580 YbbR-like protein; Region: YbbR; pfam07949 1639006581 YbbR-like protein; Region: YbbR; pfam07949 1639006582 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1639006583 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1639006584 maltose phosphorylase; Provisional; Region: PRK13807 1639006585 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1639006586 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1639006587 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1639006588 Predicted integral membrane protein [Function unknown]; Region: COG5521 1639006589 Predicted integral membrane protein [Function unknown]; Region: COG5521 1639006590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639006591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639006592 dimer interface [polypeptide binding]; other site 1639006593 conserved gate region; other site 1639006594 putative PBP binding loops; other site 1639006595 ABC-ATPase subunit interface; other site 1639006596 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1639006597 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1639006598 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639006599 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1639006600 homodimer interface [polypeptide binding]; other site 1639006601 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1639006602 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1639006603 active site 1639006604 homodimer interface [polypeptide binding]; other site 1639006605 catalytic site [active] 1639006606 CAAX protease self-immunity; Region: Abi; cl00558 1639006607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639006608 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639006609 ligand binding site [chemical binding]; other site 1639006610 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639006611 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1639006612 ligand binding site [chemical binding]; other site 1639006613 flexible hinge region; other site 1639006614 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639006615 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1639006616 intersubunit interface [polypeptide binding]; other site 1639006617 active site 1639006618 zinc binding site [ion binding]; other site 1639006619 Na+ binding site [ion binding]; other site 1639006620 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1639006621 intersubunit interface [polypeptide binding]; other site 1639006622 active site 1639006623 zinc binding site [ion binding]; other site 1639006624 Na+ binding site [ion binding]; other site 1639006625 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639006626 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639006627 active site 1639006628 P-loop; other site 1639006629 phosphorylation site [posttranslational modification] 1639006630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639006631 active site 1639006632 phosphorylation site [posttranslational modification] 1639006633 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639006634 HTH domain; Region: HTH_11; pfam08279 1639006635 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639006636 PRD domain; Region: PRD; pfam00874 1639006637 PRD domain; Region: PRD; pfam00874 1639006638 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639006639 active site 1639006640 P-loop; other site 1639006641 phosphorylation site [posttranslational modification] 1639006642 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1639006643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639006644 Walker A/P-loop; other site 1639006645 ATP binding site [chemical binding]; other site 1639006646 Q-loop/lid; other site 1639006647 ABC transporter signature motif; other site 1639006648 Walker B; other site 1639006649 D-loop; other site 1639006650 H-loop/switch region; other site 1639006651 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1639006652 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1639006653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1639006654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639006655 Coenzyme A binding pocket [chemical binding]; other site 1639006656 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1639006657 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1639006658 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1639006659 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1639006660 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639006661 DNA-binding site [nucleotide binding]; DNA binding site 1639006662 UTRA domain; Region: UTRA; pfam07702 1639006663 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 1639006664 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 1639006665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639006666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639006667 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1639006668 putative dimerization interface [polypeptide binding]; other site 1639006669 Predicted membrane protein [Function unknown]; Region: COG2855 1639006670 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1639006671 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 1639006672 putative metal binding site [ion binding]; other site 1639006673 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639006674 catalytic residues [active] 1639006675 flavodoxin; Provisional; Region: PRK09271 1639006676 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1639006677 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1639006678 dimer interface [polypeptide binding]; other site 1639006679 putative radical transfer pathway; other site 1639006680 diiron center [ion binding]; other site 1639006681 tyrosyl radical; other site 1639006682 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 1639006683 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1639006684 active site 1639006685 dimer interface [polypeptide binding]; other site 1639006686 catalytic residues [active] 1639006687 effector binding site; other site 1639006688 R2 peptide binding site; other site 1639006689 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1639006690 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1639006691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1639006692 CsbD-like; Region: CsbD; cl17424 1639006693 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639006694 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639006695 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639006696 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1639006697 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1639006698 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1639006699 conserved cys residue [active] 1639006700 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1639006701 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1639006702 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1639006703 Cupin domain; Region: Cupin_2; cl17218 1639006704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639006705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639006706 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639006707 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1639006708 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639006709 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639006710 ligand binding site [chemical binding]; other site 1639006711 flexible hinge region; other site 1639006712 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1639006713 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1639006714 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639006715 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1639006716 dimer interface [polypeptide binding]; other site 1639006717 active site 1639006718 metal binding site [ion binding]; metal-binding site 1639006719 glutathione binding site [chemical binding]; other site 1639006720 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1639006721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639006722 putative substrate translocation pore; other site 1639006723 Coenzyme A transferase; Region: CoA_trans; cl17247 1639006724 Coenzyme A transferase; Region: CoA_trans; cl17247 1639006725 Coenzyme A transferase; Region: CoA_trans; cl17247 1639006726 Coenzyme A transferase; Region: CoA_trans; smart00882 1639006727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639006728 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1639006729 Walker A motif; other site 1639006730 ATP binding site [chemical binding]; other site 1639006731 Walker B motif; other site 1639006732 arginine finger; other site 1639006733 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1639006734 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1639006735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1639006736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1639006737 metal binding site [ion binding]; metal-binding site 1639006738 active site 1639006739 I-site; other site 1639006740 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1639006741 classical (c) SDRs; Region: SDR_c; cd05233 1639006742 NAD(P) binding site [chemical binding]; other site 1639006743 active site 1639006744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639006745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639006746 Tic20-like protein; Region: Tic20; pfam09685 1639006747 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639006748 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006749 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006750 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006751 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006752 Cna protein B-type domain; Region: Cna_B; pfam05738 1639006753 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639006754 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639006755 Collagen binding domain; Region: Collagen_bind; pfam05737 1639006756 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639006757 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 1639006758 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1639006759 active site 1639006760 catalytic site [active] 1639006761 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1639006762 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1639006763 Walker A/P-loop; other site 1639006764 ATP binding site [chemical binding]; other site 1639006765 Q-loop/lid; other site 1639006766 ABC transporter signature motif; other site 1639006767 Walker B; other site 1639006768 D-loop; other site 1639006769 H-loop/switch region; other site 1639006770 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1639006771 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639006772 ABC-ATPase subunit interface; other site 1639006773 dimer interface [polypeptide binding]; other site 1639006774 putative PBP binding regions; other site 1639006775 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1639006776 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1639006777 putative ligand binding residues [chemical binding]; other site 1639006778 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1639006779 heme-binding site [chemical binding]; other site 1639006780 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1639006781 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1639006782 heme-binding site [chemical binding]; other site 1639006783 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1639006784 heme-binding site [chemical binding]; other site 1639006785 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1639006786 heme uptake protein IsdC; Region: IsdC; TIGR03656 1639006787 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1639006788 heme-binding site [chemical binding]; other site 1639006789 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 1639006790 Protein of unknown function (DUF3116); Region: DUF3116; pfam11313 1639006791 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1639006792 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1639006793 active site 1639006794 Zn binding site [ion binding]; other site 1639006795 Competence protein CoiA-like family; Region: CoiA; cl11541 1639006796 Negative regulator of genetic competence, sporulation and motility [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms / Cell motility and secretion]; Region: MecA; COG4862 1639006797 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1639006798 ArsC family; Region: ArsC; pfam03960 1639006799 putative catalytic residues [active] 1639006800 thiol/disulfide switch; other site 1639006801 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1639006802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1639006803 Walker A/P-loop; other site 1639006804 ATP binding site [chemical binding]; other site 1639006805 Q-loop/lid; other site 1639006806 ABC transporter signature motif; other site 1639006807 Walker B; other site 1639006808 D-loop; other site 1639006809 H-loop/switch region; other site 1639006810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1639006811 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1639006812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1639006813 Walker A/P-loop; other site 1639006814 ATP binding site [chemical binding]; other site 1639006815 Q-loop/lid; other site 1639006816 ABC transporter signature motif; other site 1639006817 Walker B; other site 1639006818 D-loop; other site 1639006819 H-loop/switch region; other site 1639006820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1639006821 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1639006822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639006823 dimer interface [polypeptide binding]; other site 1639006824 conserved gate region; other site 1639006825 putative PBP binding loops; other site 1639006826 ABC-ATPase subunit interface; other site 1639006827 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1639006828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639006829 dimer interface [polypeptide binding]; other site 1639006830 conserved gate region; other site 1639006831 putative PBP binding loops; other site 1639006832 ABC-ATPase subunit interface; other site 1639006833 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1639006834 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1639006835 peptide binding site [polypeptide binding]; other site 1639006836 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 1639006837 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1639006838 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1639006839 active site 1639006840 HIGH motif; other site 1639006841 dimer interface [polypeptide binding]; other site 1639006842 KMSKS motif; other site 1639006843 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1639006844 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639006845 MarR family; Region: MarR; pfam01047 1639006846 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1639006847 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1639006848 dimer interface [polypeptide binding]; other site 1639006849 active site 1639006850 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1639006851 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1639006852 dimer interface [polypeptide binding]; other site 1639006853 active site 1639006854 CoA binding pocket [chemical binding]; other site 1639006855 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1639006856 SH3-like domain; Region: SH3_8; pfam13457 1639006857 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 1639006858 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639006859 catalytic core [active] 1639006860 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1639006861 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1639006862 Clp amino terminal domain; Region: Clp_N; pfam02861 1639006863 Clp amino terminal domain; Region: Clp_N; pfam02861 1639006864 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639006865 Walker A motif; other site 1639006866 ATP binding site [chemical binding]; other site 1639006867 Walker B motif; other site 1639006868 arginine finger; other site 1639006869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1639006870 Walker A motif; other site 1639006871 ATP binding site [chemical binding]; other site 1639006872 Walker B motif; other site 1639006873 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1639006874 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1639006875 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1639006876 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639006877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639006878 active site 1639006879 motif I; other site 1639006880 motif II; other site 1639006881 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639006882 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1639006883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1639006884 ferrochelatase; Provisional; Region: PRK12435 1639006885 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1639006886 C-terminal domain interface [polypeptide binding]; other site 1639006887 active site 1639006888 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1639006889 active site 1639006890 N-terminal domain interface [polypeptide binding]; other site 1639006891 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1639006892 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1639006893 substrate binding site [chemical binding]; other site 1639006894 active site 1639006895 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1639006896 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 1639006897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639006898 Walker B; other site 1639006899 D-loop; other site 1639006900 H-loop/switch region; other site 1639006901 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639006902 Walker A/P-loop; other site 1639006903 ATP binding site [chemical binding]; other site 1639006904 Q-loop/lid; other site 1639006905 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1639006906 HIT family signature motif; other site 1639006907 catalytic residue [active] 1639006908 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 1639006909 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1639006910 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 1639006911 SurA N-terminal domain; Region: SurA_N_3; cl07813 1639006912 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1639006913 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1639006914 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1639006915 generic binding surface II; other site 1639006916 generic binding surface I; other site 1639006917 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639006918 Zn2+ binding site [ion binding]; other site 1639006919 Mg2+ binding site [ion binding]; other site 1639006920 Uncharacterized conserved protein [Function unknown]; Region: COG4717 1639006921 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1639006922 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1639006923 active site 1639006924 metal binding site [ion binding]; metal-binding site 1639006925 DNA binding site [nucleotide binding] 1639006926 hypothetical protein; Provisional; Region: PRK13676 1639006927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1639006928 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1639006929 Class II fumarases; Region: Fumarase_classII; cd01362 1639006930 active site 1639006931 tetramer interface [polypeptide binding]; other site 1639006932 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1639006933 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1639006934 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1639006935 Walker A/P-loop; other site 1639006936 ATP binding site [chemical binding]; other site 1639006937 Q-loop/lid; other site 1639006938 ABC transporter signature motif; other site 1639006939 Walker B; other site 1639006940 D-loop; other site 1639006941 H-loop/switch region; other site 1639006942 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1639006943 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1639006944 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1639006945 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1639006946 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1639006947 Domain of unknown function DUF21; Region: DUF21; pfam01595 1639006948 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1639006949 Transporter associated domain; Region: CorC_HlyC; smart01091 1639006950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639006951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639006952 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1639006953 putative dimerization interface [polypeptide binding]; other site 1639006954 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1639006955 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1639006956 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1639006957 active site 1639006958 FMN binding site [chemical binding]; other site 1639006959 substrate binding site [chemical binding]; other site 1639006960 putative catalytic residue [active] 1639006961 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 1639006962 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1639006963 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1639006964 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1639006965 shikimate binding site; other site 1639006966 NAD(P) binding site [chemical binding]; other site 1639006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639006968 putative substrate translocation pore; other site 1639006969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639006970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639006971 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639006972 putative substrate translocation pore; other site 1639006973 Predicted transcriptional regulators [Transcription]; Region: COG1725 1639006974 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1639006975 DNA-binding site [nucleotide binding]; DNA binding site 1639006976 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1639006977 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1639006978 DNA binding site [nucleotide binding] 1639006979 active site 1639006980 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1639006981 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1639006982 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639006983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639006984 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1639006985 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1639006986 active site 1639006987 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1639006988 putative dimer interface [polypeptide binding]; other site 1639006989 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639006990 ligand binding site [chemical binding]; other site 1639006991 Zn binding site [ion binding]; other site 1639006992 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1639006993 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1639006994 active site 1639006995 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639006996 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639006997 active site 1639006998 catalytic tetrad [active] 1639006999 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1639007000 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1639007001 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1639007002 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1639007003 substrate binding pocket [chemical binding]; other site 1639007004 membrane-bound complex binding site; other site 1639007005 hinge residues; other site 1639007006 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639007007 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1639007008 Walker A/P-loop; other site 1639007009 ATP binding site [chemical binding]; other site 1639007010 Q-loop/lid; other site 1639007011 ABC transporter signature motif; other site 1639007012 Walker B; other site 1639007013 D-loop; other site 1639007014 H-loop/switch region; other site 1639007015 aspartate aminotransferase; Provisional; Region: PRK06348 1639007016 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639007017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639007018 homodimer interface [polypeptide binding]; other site 1639007019 catalytic residue [active] 1639007020 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1639007021 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639007022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007023 motif II; other site 1639007024 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1639007025 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 1639007026 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639007027 methionine cluster; other site 1639007028 active site 1639007029 phosphorylation site [posttranslational modification] 1639007030 metal binding site [ion binding]; metal-binding site 1639007031 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1639007032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639007033 Coenzyme A binding pocket [chemical binding]; other site 1639007034 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1639007035 esterase; Provisional; Region: PRK10566 1639007036 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1639007037 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639007038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1639007039 motif II; other site 1639007040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007041 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1639007042 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639007043 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1639007044 hypothetical protein; Provisional; Region: PRK13673 1639007045 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1639007046 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1639007047 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1639007048 Part of AAA domain; Region: AAA_19; pfam13245 1639007049 Family description; Region: UvrD_C_2; pfam13538 1639007050 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1639007051 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1639007052 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1639007053 IDEAL domain; Region: IDEAL; pfam08858 1639007054 ComK protein; Region: ComK; cl11560 1639007055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1639007056 AP2 domain; Region: AP2; pfam00847 1639007057 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1639007058 Domain of unknown function (DUF3597); Region: DUF3597; pfam12200 1639007059 Phage holin; Region: Phage_holin_5; pfam06946 1639007060 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 1639007061 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 1639007062 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1639007063 Phage tail protein; Region: Sipho_tail; cl17486 1639007064 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1639007065 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1639007066 Minor capsid protein; Region: Minor_capsid_2; pfam11114 1639007067 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 1639007068 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 1639007069 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 1639007070 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 1639007071 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1639007072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639007073 non-specific DNA binding site [nucleotide binding]; other site 1639007074 salt bridge; other site 1639007075 sequence-specific DNA binding site [nucleotide binding]; other site 1639007076 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1639007077 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639007078 active site 1639007079 phosphorylation site [posttranslational modification] 1639007080 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639007081 active site 1639007082 P-loop; other site 1639007083 phosphorylation site [posttranslational modification] 1639007084 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639007085 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1639007086 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1639007087 putative substrate binding site [chemical binding]; other site 1639007088 putative ATP binding site [chemical binding]; other site 1639007089 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639007090 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1639007091 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639007092 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1639007093 trimer interface [polypeptide binding]; other site 1639007094 active site 1639007095 G bulge; other site 1639007096 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1639007097 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1639007098 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1639007099 non-specific DNA interactions [nucleotide binding]; other site 1639007100 DNA binding site [nucleotide binding] 1639007101 sequence specific DNA binding site [nucleotide binding]; other site 1639007102 putative cAMP binding site [chemical binding]; other site 1639007103 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1639007104 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1639007105 substrate binding site [chemical binding]; other site 1639007106 ATP binding site [chemical binding]; other site 1639007107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1639007108 RNA binding surface [nucleotide binding]; other site 1639007109 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1639007110 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1639007111 active site 1639007112 non-prolyl cis peptide bond; other site 1639007113 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1639007114 catalytic residues [active] 1639007115 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1639007116 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1639007117 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1639007118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639007119 H-loop/switch region; other site 1639007120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639007121 Walker A/P-loop; other site 1639007122 ATP binding site [chemical binding]; other site 1639007123 ABC transporter; Region: ABC_tran; pfam00005 1639007124 Q-loop/lid; other site 1639007125 ABC transporter signature motif; other site 1639007126 Walker B; other site 1639007127 D-loop; other site 1639007128 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1639007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639007130 dimer interface [polypeptide binding]; other site 1639007131 conserved gate region; other site 1639007132 putative PBP binding loops; other site 1639007133 ABC-ATPase subunit interface; other site 1639007134 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1639007135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639007136 dimer interface [polypeptide binding]; other site 1639007137 conserved gate region; other site 1639007138 putative PBP binding loops; other site 1639007139 ABC-ATPase subunit interface; other site 1639007140 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1639007141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1639007142 substrate binding pocket [chemical binding]; other site 1639007143 membrane-bound complex binding site; other site 1639007144 hinge residues; other site 1639007145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639007146 Coenzyme A binding pocket [chemical binding]; other site 1639007147 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1639007148 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1639007149 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639007150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1639007151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1639007152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1639007153 dimerization interface [polypeptide binding]; other site 1639007154 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1639007155 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1639007156 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1639007157 active site 1639007158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639007159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639007160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639007161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639007162 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1639007163 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1639007164 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1639007165 active site 1639007166 trimer interface [polypeptide binding]; other site 1639007167 allosteric site; other site 1639007168 active site lid [active] 1639007169 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1639007170 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639007171 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007172 active site 1639007173 motif I; other site 1639007174 motif II; other site 1639007175 Predicted membrane protein [Function unknown]; Region: COG1511 1639007176 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1639007177 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1639007178 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1639007179 Predicted transcriptional regulator [Transcription]; Region: COG1959 1639007180 Transcriptional regulator; Region: Rrf2; pfam02082 1639007181 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1639007182 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639007183 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639007184 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 1639007185 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639007186 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 1639007187 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1639007188 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1639007189 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1639007190 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1639007191 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1639007192 active site 1639007193 dimer interface [polypeptide binding]; other site 1639007194 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1639007195 dimer interface [polypeptide binding]; other site 1639007196 active site 1639007197 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1639007198 nudix motif; other site 1639007199 general stress protein 13; Validated; Region: PRK08059 1639007200 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1639007201 RNA binding site [nucleotide binding]; other site 1639007202 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1639007203 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1639007204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639007205 homodimer interface [polypeptide binding]; other site 1639007206 catalytic residue [active] 1639007207 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1639007208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639007209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639007210 Walker A/P-loop; other site 1639007211 ATP binding site [chemical binding]; other site 1639007212 Q-loop/lid; other site 1639007213 ABC transporter signature motif; other site 1639007214 Walker B; other site 1639007215 D-loop; other site 1639007216 H-loop/switch region; other site 1639007217 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639007218 active site 1639007219 P-loop; other site 1639007220 phosphorylation site [posttranslational modification] 1639007221 aspartate kinase; Reviewed; Region: PRK09034 1639007222 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1639007223 putative catalytic residues [active] 1639007224 putative nucleotide binding site [chemical binding]; other site 1639007225 putative aspartate binding site [chemical binding]; other site 1639007226 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1639007227 allosteric regulatory residue; other site 1639007228 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1639007229 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1639007230 active site 1639007231 drug efflux system protein MdtG; Provisional; Region: PRK09874 1639007232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639007233 putative substrate translocation pore; other site 1639007234 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1639007235 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1639007236 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12504 1639007237 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1639007238 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 1639007239 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1639007240 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 1639007241 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1639007242 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1639007243 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 1639007244 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12585 1639007245 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1639007246 CoenzymeA binding site [chemical binding]; other site 1639007247 subunit interaction site [polypeptide binding]; other site 1639007248 PHB binding site; other site 1639007249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1963 1639007250 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1639007251 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1639007252 Cl- selectivity filter; other site 1639007253 Cl- binding residues [ion binding]; other site 1639007254 pore gating glutamate residue; other site 1639007255 dimer interface [polypeptide binding]; other site 1639007256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 1639007257 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1639007258 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639007259 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1639007260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639007261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639007262 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1639007263 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1639007264 NAD(P) binding site [chemical binding]; other site 1639007265 putative active site [active] 1639007266 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1639007267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4837 1639007268 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639007269 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639007270 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639007271 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639007272 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1639007273 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1639007274 tetramer interfaces [polypeptide binding]; other site 1639007275 binuclear metal-binding site [ion binding]; other site 1639007276 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1639007277 Domain of unknown function DUF21; Region: DUF21; pfam01595 1639007278 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1639007279 Transporter associated domain; Region: CorC_HlyC; smart01091 1639007280 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1639007281 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639007282 Coenzyme A binding pocket [chemical binding]; other site 1639007283 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1639007284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007285 active site 1639007286 motif I; other site 1639007287 motif II; other site 1639007288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 1639007290 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1639007291 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1639007292 active site 1639007293 metal binding site [ion binding]; metal-binding site 1639007294 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1639007295 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1639007296 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1639007297 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1639007298 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1639007299 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1639007300 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1639007301 trimerization site [polypeptide binding]; other site 1639007302 active site 1639007303 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1639007304 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1639007305 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639007306 catalytic residue [active] 1639007307 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1639007308 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1639007309 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1639007310 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1639007311 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1639007312 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1639007313 Walker A/P-loop; other site 1639007314 ATP binding site [chemical binding]; other site 1639007315 Q-loop/lid; other site 1639007316 ABC transporter signature motif; other site 1639007317 Walker B; other site 1639007318 D-loop; other site 1639007319 H-loop/switch region; other site 1639007320 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1639007321 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1639007322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639007323 ABC-ATPase subunit interface; other site 1639007324 putative PBP binding loops; other site 1639007325 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1639007326 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1639007327 Walker A/P-loop; other site 1639007328 ATP binding site [chemical binding]; other site 1639007329 Q-loop/lid; other site 1639007330 ABC transporter signature motif; other site 1639007331 Walker B; other site 1639007332 D-loop; other site 1639007333 H-loop/switch region; other site 1639007334 NIL domain; Region: NIL; pfam09383 1639007335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639007336 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639007337 DNA binding site [nucleotide binding] 1639007338 Response regulator receiver domain; Region: Response_reg; pfam00072 1639007339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639007340 active site 1639007341 phosphorylation site [posttranslational modification] 1639007342 intermolecular recognition site; other site 1639007343 dimerization interface [polypeptide binding]; other site 1639007344 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1639007345 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1639007346 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639007347 catalytic residues [active] 1639007348 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1639007349 lipoyl attachment site [posttranslational modification]; other site 1639007350 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1639007351 ArsC family; Region: ArsC; pfam03960 1639007352 putative ArsC-like catalytic residues; other site 1639007353 putative TRX-like catalytic residues [active] 1639007354 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1639007355 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1639007356 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1639007357 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1639007358 Walker A/P-loop; other site 1639007359 ATP binding site [chemical binding]; other site 1639007360 Q-loop/lid; other site 1639007361 ABC transporter signature motif; other site 1639007362 Walker B; other site 1639007363 D-loop; other site 1639007364 H-loop/switch region; other site 1639007365 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1639007366 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1639007367 ABC-ATPase subunit interface; other site 1639007368 dimer interface [polypeptide binding]; other site 1639007369 putative PBP binding regions; other site 1639007370 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1639007371 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1639007372 intersubunit interface [polypeptide binding]; other site 1639007373 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1639007374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639007375 catalytic residue [active] 1639007376 SdpI/YhfL protein family; Region: SdpI; pfam13630 1639007377 CAT RNA binding domain; Region: CAT_RBD; smart01061 1639007378 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1639007379 PRD domain; Region: PRD; pfam00874 1639007380 PRD domain; Region: PRD; pfam00874 1639007381 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1639007382 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1639007383 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 1639007384 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1639007385 Predicted transcriptional regulator [Transcription]; Region: COG2378 1639007386 HTH domain; Region: HTH_11; pfam08279 1639007387 WYL domain; Region: WYL; pfam13280 1639007388 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1639007389 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1639007390 putative active site [active] 1639007391 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1639007392 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 1639007393 active site 1639007394 catalytic site [active] 1639007395 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1639007396 putative metal binding site [ion binding]; other site 1639007397 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1639007398 putative metal binding site [ion binding]; other site 1639007399 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639007400 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1639007401 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1639007402 active site 1639007403 catalytic site [active] 1639007404 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1639007405 putative metal binding site [ion binding]; other site 1639007406 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1639007407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639007408 non-specific DNA binding site [nucleotide binding]; other site 1639007409 salt bridge; other site 1639007410 sequence-specific DNA binding site [nucleotide binding]; other site 1639007411 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1639007412 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1639007413 SmpB-tmRNA interface; other site 1639007414 RNB domain; Region: RNB; pfam00773 1639007415 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1639007416 RNA binding site [nucleotide binding]; other site 1639007417 RNB domain; Region: RNB; pfam00773 1639007418 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1639007419 Esterase/lipase [General function prediction only]; Region: COG1647 1639007420 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1639007421 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1639007422 Preprotein translocase SecG subunit; Region: SecG; cl09123 1639007423 Esterase/lipase [General function prediction only]; Region: COG1647 1639007424 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1639007425 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1639007426 PGAP1-like protein; Region: PGAP1; pfam07819 1639007427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1639007428 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1639007429 phosphoglyceromutase; Provisional; Region: PRK05434 1639007430 triosephosphate isomerase; Provisional; Region: PRK14567 1639007431 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1639007432 substrate binding site [chemical binding]; other site 1639007433 dimer interface [polypeptide binding]; other site 1639007434 catalytic triad [active] 1639007435 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1639007436 Phosphoglycerate kinase; Region: PGK; pfam00162 1639007437 substrate binding site [chemical binding]; other site 1639007438 hinge regions; other site 1639007439 ADP binding site [chemical binding]; other site 1639007440 catalytic site [active] 1639007441 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1639007442 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1639007443 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1639007444 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1639007445 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1639007446 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1639007447 RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395 1639007448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639007449 DNA binding site [nucleotide binding] 1639007450 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1639007451 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1639007452 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1639007453 active site 1639007454 dimer interface [polypeptide binding]; other site 1639007455 MMPL family; Region: MMPL; pfam03176 1639007456 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1639007457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639007458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639007459 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1639007460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 1639007461 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1639007462 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 1639007463 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1639007464 Interdomain contacts; other site 1639007465 Cytokine receptor motif; other site 1639007466 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1639007467 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1639007468 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1639007469 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1639007470 Clp protease; Region: CLP_protease; pfam00574 1639007471 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1639007472 oligomer interface [polypeptide binding]; other site 1639007473 active site residues [active] 1639007474 amino acid transporter; Region: 2A0306; TIGR00909 1639007475 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1639007476 Bacterial adhesion/invasion protein N terminal; Region: Internalin_N; pfam12354 1639007477 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1639007478 Leucine rich repeat; Region: LRR_8; pfam13855 1639007479 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639007480 phosphate binding site [ion binding]; other site 1639007481 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639007482 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639007483 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1639007484 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1639007485 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1639007486 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1639007487 phosphate binding site [ion binding]; other site 1639007488 putative substrate binding pocket [chemical binding]; other site 1639007489 dimer interface [polypeptide binding]; other site 1639007490 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1639007491 AAA domain; Region: AAA_18; pfam13238 1639007492 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1639007493 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1639007494 active site 1639007495 substrate binding site [chemical binding]; other site 1639007496 metal binding site [ion binding]; metal-binding site 1639007497 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1639007498 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1639007499 active site 1639007500 catalytic residues [active] 1639007501 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1639007502 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1639007503 NAD binding site [chemical binding]; other site 1639007504 homodimer interface [polypeptide binding]; other site 1639007505 active site 1639007506 substrate binding site [chemical binding]; other site 1639007507 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1639007508 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1639007509 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639007510 TPR repeat; Region: TPR_11; pfam13414 1639007511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639007512 binding surface 1639007513 TPR motif; other site 1639007514 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1639007515 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1639007516 binding surface 1639007517 TPR motif; other site 1639007518 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1639007519 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1639007520 putative trimer interface [polypeptide binding]; other site 1639007521 putative CoA binding site [chemical binding]; other site 1639007522 pyrophosphatase PpaX; Provisional; Region: PRK13288 1639007523 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639007524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007525 motif II; other site 1639007526 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1639007527 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1639007528 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1639007529 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1639007530 Hpr binding site; other site 1639007531 active site 1639007532 homohexamer subunit interaction site [polypeptide binding]; other site 1639007533 Predicted membrane protein [Function unknown]; Region: COG1950 1639007534 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1639007535 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 1639007536 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1639007537 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1639007538 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1639007539 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1639007540 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1639007541 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1639007542 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1639007543 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1639007544 excinuclease ABC subunit B; Provisional; Region: PRK05298 1639007545 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639007546 ATP binding site [chemical binding]; other site 1639007547 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639007548 nucleotide binding region [chemical binding]; other site 1639007549 ATP-binding site [chemical binding]; other site 1639007550 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1639007551 UvrB/uvrC motif; Region: UVR; pfam02151 1639007552 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 1639007553 HD containing hydrolase-like enzyme; Region: HD_2; pfam12917 1639007554 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1639007555 dimerization interface [polypeptide binding]; other site 1639007556 putative DNA binding site [nucleotide binding]; other site 1639007557 putative Zn2+ binding site [ion binding]; other site 1639007558 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1639007559 PhoU domain; Region: PhoU; pfam01895 1639007560 PhoU domain; Region: PhoU; pfam01895 1639007561 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1639007562 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1639007563 Walker A/P-loop; other site 1639007564 ATP binding site [chemical binding]; other site 1639007565 Q-loop/lid; other site 1639007566 ABC transporter signature motif; other site 1639007567 Walker B; other site 1639007568 D-loop; other site 1639007569 H-loop/switch region; other site 1639007570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639007571 ABC transporter signature motif; other site 1639007572 D-loop; other site 1639007573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639007574 Walker A/P-loop; other site 1639007575 ATP binding site [chemical binding]; other site 1639007576 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1639007577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639007578 dimer interface [polypeptide binding]; other site 1639007579 conserved gate region; other site 1639007580 ABC-ATPase subunit interface; other site 1639007581 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1639007582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639007583 dimer interface [polypeptide binding]; other site 1639007584 conserved gate region; other site 1639007585 putative PBP binding loops; other site 1639007586 ABC-ATPase subunit interface; other site 1639007587 PBP superfamily domain; Region: PBP_like_2; cl17296 1639007588 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1639007589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1639007590 HAMP domain; Region: HAMP; pfam00672 1639007591 dimerization interface [polypeptide binding]; other site 1639007592 PAS domain; Region: PAS; smart00091 1639007593 putative active site [active] 1639007594 heme pocket [chemical binding]; other site 1639007595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639007596 dimer interface [polypeptide binding]; other site 1639007597 phosphorylation site [posttranslational modification] 1639007598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639007599 ATP binding site [chemical binding]; other site 1639007600 Mg2+ binding site [ion binding]; other site 1639007601 G-X-G motif; other site 1639007602 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639007603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639007604 active site 1639007605 phosphorylation site [posttranslational modification] 1639007606 intermolecular recognition site; other site 1639007607 dimerization interface [polypeptide binding]; other site 1639007608 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639007609 DNA binding site [nucleotide binding] 1639007610 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1639007611 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1639007612 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1639007613 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1639007614 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1639007615 putative active site [active] 1639007616 catalytic site [active] 1639007617 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1639007618 putative active site [active] 1639007619 catalytic site [active] 1639007620 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1639007621 Peptidase family M23; Region: Peptidase_M23; pfam01551 1639007622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1639007623 NlpC/P60 family; Region: NLPC_P60; pfam00877 1639007624 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1639007625 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1639007626 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1639007627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639007628 Walker A/P-loop; other site 1639007629 ATP binding site [chemical binding]; other site 1639007630 Q-loop/lid; other site 1639007631 ABC transporter signature motif; other site 1639007632 Walker B; other site 1639007633 D-loop; other site 1639007634 H-loop/switch region; other site 1639007635 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1639007636 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639007637 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1639007638 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1639007639 RF-1 domain; Region: RF-1; cl17422 1639007640 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1639007641 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1639007642 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1639007643 nucleotide binding region [chemical binding]; other site 1639007644 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1639007645 ATP-binding site [chemical binding]; other site 1639007646 SEC-C motif; Region: SEC-C; pfam02810 1639007647 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1639007648 30S subunit binding site; other site 1639007649 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1639007650 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639007651 active site 1639007652 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 1639007653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639007654 ATP binding site [chemical binding]; other site 1639007655 putative Mg++ binding site [ion binding]; other site 1639007656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639007657 nucleotide binding region [chemical binding]; other site 1639007658 ATP-binding site [chemical binding]; other site 1639007659 EDD domain protein, DegV family; Region: DegV; TIGR00762 1639007660 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1639007661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1639007662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639007663 active site 1639007664 phosphorylation site [posttranslational modification] 1639007665 intermolecular recognition site; other site 1639007666 dimerization interface [polypeptide binding]; other site 1639007667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1639007668 DNA binding residues [nucleotide binding] 1639007669 dimerization interface [polypeptide binding]; other site 1639007670 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1639007671 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1639007672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1639007673 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1639007674 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1639007675 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1639007676 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1639007677 Mg++ binding site [ion binding]; other site 1639007678 putative catalytic motif [active] 1639007679 substrate binding site [chemical binding]; other site 1639007680 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1639007681 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1639007682 active site 1639007683 octamer interface [polypeptide binding]; other site 1639007684 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1639007685 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1639007686 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1639007687 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1639007688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1639007689 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1639007690 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1639007691 MreB and similar proteins; Region: MreB_like; cd10225 1639007692 nucleotide binding site [chemical binding]; other site 1639007693 Mg binding site [ion binding]; other site 1639007694 putative protofilament interaction site [polypeptide binding]; other site 1639007695 RodZ interaction site [polypeptide binding]; other site 1639007696 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1639007697 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1639007698 hinge; other site 1639007699 active site 1639007700 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1639007701 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1639007702 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1639007703 gamma subunit interface [polypeptide binding]; other site 1639007704 epsilon subunit interface [polypeptide binding]; other site 1639007705 LBP interface [polypeptide binding]; other site 1639007706 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1639007707 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1639007708 Walker A motif; other site 1639007709 ATP binding site [chemical binding]; other site 1639007710 alpha subunit interaction interface [polypeptide binding]; other site 1639007711 Walker B motif; other site 1639007712 inhibitor binding site; inhibition site 1639007713 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1639007714 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1639007715 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1639007716 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 1639007717 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1639007718 epsilon subunit interface [polypeptide binding]; other site 1639007719 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 1639007720 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1639007721 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1639007722 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1639007723 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1639007724 beta subunit interaction interface [polypeptide binding]; other site 1639007725 Walker A motif; other site 1639007726 ATP binding site [chemical binding]; other site 1639007727 Walker B motif; other site 1639007728 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1639007729 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1639007730 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1639007731 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1639007732 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1639007733 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1639007734 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1639007735 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1639007736 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1639007737 active site 1639007738 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639007739 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639007740 catalytic residue [active] 1639007741 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639007742 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1639007743 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1639007744 active site 1639007745 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1639007746 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1639007747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639007748 S-adenosylmethionine binding site [chemical binding]; other site 1639007749 RF-1 domain; Region: RF-1; pfam00472 1639007750 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1639007751 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1639007752 homoserine kinase; Provisional; Region: PRK01212 1639007753 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1639007754 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1639007755 thymidine kinase; Provisional; Region: PRK04296 1639007756 threonine synthase; Reviewed; Region: PRK06721 1639007757 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1639007758 homodimer interface [polypeptide binding]; other site 1639007759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639007760 catalytic residue [active] 1639007761 homoserine dehydrogenase; Provisional; Region: PRK06349 1639007762 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1639007763 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1639007764 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1639007765 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1639007766 Predicted membrane protein [Function unknown]; Region: COG2246 1639007767 GtrA-like protein; Region: GtrA; pfam04138 1639007768 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1639007769 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1639007770 Ligand binding site; other site 1639007771 Putative Catalytic site; other site 1639007772 DXD motif; other site 1639007773 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1639007774 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1639007775 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1639007776 RNA binding site [nucleotide binding]; other site 1639007777 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1639007778 multimer interface [polypeptide binding]; other site 1639007779 Walker A motif; other site 1639007780 ATP binding site [chemical binding]; other site 1639007781 Walker B motif; other site 1639007782 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1639007783 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1639007784 hinge; other site 1639007785 active site 1639007786 Predicted integral membrane protein [Function unknown]; Region: COG0392 1639007787 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1639007788 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1639007789 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1639007790 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1639007791 putative ADP-binding pocket [chemical binding]; other site 1639007792 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1639007793 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1639007794 intersubunit interface [polypeptide binding]; other site 1639007795 active site 1639007796 zinc binding site [ion binding]; other site 1639007797 Na+ binding site [ion binding]; other site 1639007798 putative lipid kinase; Reviewed; Region: PRK13055 1639007799 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1639007800 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 1639007801 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1639007802 substrate binding site [chemical binding]; other site 1639007803 SH3-like domain; Region: SH3_8; pfam13457 1639007804 SH3-like domain; Region: SH3_8; pfam13457 1639007805 SH3-like domain; Region: SH3_8; pfam13457 1639007806 SH3-like domain; Region: SH3_8; pfam13457 1639007807 CTP synthetase; Validated; Region: pyrG; PRK05380 1639007808 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1639007809 Catalytic site [active] 1639007810 active site 1639007811 UTP binding site [chemical binding]; other site 1639007812 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1639007813 active site 1639007814 putative oxyanion hole; other site 1639007815 catalytic triad [active] 1639007816 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1639007817 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1639007818 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1639007819 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1639007820 active site 1639007821 HIGH motif; other site 1639007822 KMSK motif region; other site 1639007823 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1639007824 tRNA binding surface [nucleotide binding]; other site 1639007825 anticodon binding site; other site 1639007826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4506 1639007827 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1639007828 Peptidase family M50; Region: Peptidase_M50; pfam02163 1639007829 active site 1639007830 putative substrate binding region [chemical binding]; other site 1639007831 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1639007832 active site 1 [active] 1639007833 dimer interface [polypeptide binding]; other site 1639007834 hexamer interface [polypeptide binding]; other site 1639007835 active site 2 [active] 1639007836 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1639007837 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639007838 Zn2+ binding site [ion binding]; other site 1639007839 Mg2+ binding site [ion binding]; other site 1639007840 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1639007841 Predicted integral membrane protein [Function unknown]; Region: COG5658 1639007842 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1639007843 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1639007844 catalytic triad [active] 1639007845 metal binding site [ion binding]; metal-binding site 1639007846 conserved cis-peptide bond; other site 1639007847 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1639007848 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1639007849 folate binding site [chemical binding]; other site 1639007850 NADP+ binding site [chemical binding]; other site 1639007851 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1639007852 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1639007853 putative NAD(P) binding site [chemical binding]; other site 1639007854 dimer interface [polypeptide binding]; other site 1639007855 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1639007856 Collagen binding domain; Region: Collagen_bind; pfam05737 1639007857 Collagen binding domain; Region: Collagen_bind; pfam05737 1639007858 Collagen binding domain; Region: Collagen_bind; pfam05737 1639007859 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007860 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007861 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007862 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007863 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007864 Cna protein B-type domain; Region: Cna_B; pfam05738 1639007865 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1639007866 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639007867 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639007868 active site 1639007869 motif I; other site 1639007870 motif II; other site 1639007871 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1639007872 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1639007873 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1639007874 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1639007875 Walker A/P-loop; other site 1639007876 ATP binding site [chemical binding]; other site 1639007877 Q-loop/lid; other site 1639007878 ABC transporter signature motif; other site 1639007879 Walker B; other site 1639007880 D-loop; other site 1639007881 H-loop/switch region; other site 1639007882 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1639007883 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1639007884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1639007885 dimerization interface [polypeptide binding]; other site 1639007886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639007887 dimer interface [polypeptide binding]; other site 1639007888 phosphorylation site [posttranslational modification] 1639007889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639007890 ATP binding site [chemical binding]; other site 1639007891 Mg2+ binding site [ion binding]; other site 1639007892 G-X-G motif; other site 1639007893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639007894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639007895 active site 1639007896 phosphorylation site [posttranslational modification] 1639007897 intermolecular recognition site; other site 1639007898 dimerization interface [polypeptide binding]; other site 1639007899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639007900 DNA binding site [nucleotide binding] 1639007901 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1639007902 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1639007903 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1639007904 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1639007905 molybdopterin cofactor binding site; other site 1639007906 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1639007907 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1639007908 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1639007909 catalytic loop [active] 1639007910 iron binding site [ion binding]; other site 1639007911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639007913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639007914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1639007915 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1639007916 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1639007917 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639007918 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639007919 active site 1639007920 catalytic tetrad [active] 1639007921 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639007922 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639007923 DNA binding residues [nucleotide binding] 1639007924 putative dimer interface [polypeptide binding]; other site 1639007925 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1639007926 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1639007927 23S rRNA interface [nucleotide binding]; other site 1639007928 L3 interface [polypeptide binding]; other site 1639007929 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1639007930 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1639007931 dimerization interface 3.5A [polypeptide binding]; other site 1639007932 active site 1639007933 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1639007934 Cobalt transport protein; Region: CbiQ; cl00463 1639007935 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 1639007936 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1639007937 Walker A/P-loop; other site 1639007938 ATP binding site [chemical binding]; other site 1639007939 Q-loop/lid; other site 1639007940 ABC transporter signature motif; other site 1639007941 Walker B; other site 1639007942 D-loop; other site 1639007943 H-loop/switch region; other site 1639007944 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1639007945 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1639007946 Walker A/P-loop; other site 1639007947 ATP binding site [chemical binding]; other site 1639007948 Q-loop/lid; other site 1639007949 ABC transporter signature motif; other site 1639007950 Walker B; other site 1639007951 D-loop; other site 1639007952 H-loop/switch region; other site 1639007953 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1639007954 MgtC family; Region: MgtC; pfam02308 1639007955 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1639007956 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1639007957 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1639007958 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1639007959 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1639007960 alphaNTD - beta interaction site [polypeptide binding]; other site 1639007961 alphaNTD homodimer interface [polypeptide binding]; other site 1639007962 alphaNTD - beta' interaction site [polypeptide binding]; other site 1639007963 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1639007964 30S ribosomal protein S11; Validated; Region: PRK05309 1639007965 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1639007966 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1639007967 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1639007968 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1639007969 rRNA binding site [nucleotide binding]; other site 1639007970 predicted 30S ribosome binding site; other site 1639007971 adenylate kinase; Reviewed; Region: adk; PRK00279 1639007972 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1639007973 AMP-binding site [chemical binding]; other site 1639007974 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1639007975 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1639007976 SecY translocase; Region: SecY; pfam00344 1639007977 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1639007978 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1639007979 23S rRNA binding site [nucleotide binding]; other site 1639007980 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1639007981 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1639007982 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1639007983 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1639007984 5S rRNA interface [nucleotide binding]; other site 1639007985 L27 interface [polypeptide binding]; other site 1639007986 23S rRNA interface [nucleotide binding]; other site 1639007987 L5 interface [polypeptide binding]; other site 1639007988 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1639007989 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1639007990 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1639007991 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1639007992 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1639007993 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1639007994 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1639007995 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1639007996 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1639007997 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1639007998 RNA binding site [nucleotide binding]; other site 1639007999 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1639008000 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1639008001 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1639008002 23S rRNA interface [nucleotide binding]; other site 1639008003 putative translocon interaction site; other site 1639008004 signal recognition particle (SRP54) interaction site; other site 1639008005 L23 interface [polypeptide binding]; other site 1639008006 trigger factor interaction site; other site 1639008007 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1639008008 23S rRNA interface [nucleotide binding]; other site 1639008009 5S rRNA interface [nucleotide binding]; other site 1639008010 putative antibiotic binding site [chemical binding]; other site 1639008011 L25 interface [polypeptide binding]; other site 1639008012 L27 interface [polypeptide binding]; other site 1639008013 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1639008014 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1639008015 G-X-X-G motif; other site 1639008016 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1639008017 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1639008018 putative translocon binding site; other site 1639008019 protein-rRNA interface [nucleotide binding]; other site 1639008020 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1639008021 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1639008022 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1639008023 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1639008024 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1639008025 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1639008026 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1639008027 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1639008028 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1639008029 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 1639008030 UbiA prenyltransferase family; Region: UbiA; pfam01040 1639008031 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1639008032 ApbE family; Region: ApbE; pfam02424 1639008033 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 1639008034 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1639008035 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 1639008036 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1639008037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1639008038 Predicted membrane protein [Function unknown]; Region: COG2259 1639008039 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 1639008040 trimer interface [polypeptide binding]; other site 1639008041 Predicted membrane protein [Function unknown]; Region: COG4769 1639008042 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1639008043 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1639008044 substrate binding pocket [chemical binding]; other site 1639008045 chain length determination region; other site 1639008046 substrate-Mg2+ binding site; other site 1639008047 catalytic residues [active] 1639008048 aspartate-rich region 1; other site 1639008049 active site lid residues [active] 1639008050 aspartate-rich region 2; other site 1639008051 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1639008052 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 1639008053 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1639008054 hypothetical protein; Provisional; Region: PRK02947 1639008055 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008056 putative active site [active] 1639008057 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 1639008058 Uncharacterized protein, putative amidase [General function prediction only]; Region: COG1402 1639008059 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1639008060 active site 1639008061 substrate binding pocket [chemical binding]; other site 1639008062 homodimer interaction site [polypeptide binding]; other site 1639008063 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1639008064 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1639008065 active site 1639008066 P-loop; other site 1639008067 phosphorylation site [posttranslational modification] 1639008068 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008069 active site 1639008070 phosphorylation site [posttranslational modification] 1639008071 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1639008072 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639008073 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639008074 PRD domain; Region: PRD; pfam00874 1639008075 PRD domain; Region: PRD; pfam00874 1639008076 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639008077 active site 1639008078 P-loop; other site 1639008079 phosphorylation site [posttranslational modification] 1639008080 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008081 active site 1639008082 phosphorylation site [posttranslational modification] 1639008083 elongation factor Tu; Reviewed; Region: PRK00049 1639008084 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1639008085 G1 box; other site 1639008086 GEF interaction site [polypeptide binding]; other site 1639008087 GTP/Mg2+ binding site [chemical binding]; other site 1639008088 Switch I region; other site 1639008089 G2 box; other site 1639008090 G3 box; other site 1639008091 Switch II region; other site 1639008092 G4 box; other site 1639008093 G5 box; other site 1639008094 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1639008095 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1639008096 Antibiotic Binding Site [chemical binding]; other site 1639008097 elongation factor G; Reviewed; Region: PRK00007 1639008098 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1639008099 G1 box; other site 1639008100 putative GEF interaction site [polypeptide binding]; other site 1639008101 GTP/Mg2+ binding site [chemical binding]; other site 1639008102 Switch I region; other site 1639008103 G2 box; other site 1639008104 G3 box; other site 1639008105 Switch II region; other site 1639008106 G4 box; other site 1639008107 G5 box; other site 1639008108 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1639008109 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1639008110 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1639008111 30S ribosomal protein S7; Validated; Region: PRK05302 1639008112 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1639008113 S17 interaction site [polypeptide binding]; other site 1639008114 S8 interaction site; other site 1639008115 16S rRNA interaction site [nucleotide binding]; other site 1639008116 streptomycin interaction site [chemical binding]; other site 1639008117 23S rRNA interaction site [nucleotide binding]; other site 1639008118 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1639008119 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 1639008120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1639008121 Zn2+ binding site [ion binding]; other site 1639008122 Mg2+ binding site [ion binding]; other site 1639008123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639008124 Coenzyme A binding pocket [chemical binding]; other site 1639008125 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1639008126 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1639008127 substrate binding site [chemical binding]; other site 1639008128 hexamer interface [polypeptide binding]; other site 1639008129 metal binding site [ion binding]; metal-binding site 1639008130 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1639008131 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1639008132 TPP-binding site [chemical binding]; other site 1639008133 dimer interface [polypeptide binding]; other site 1639008134 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1639008135 PYR/PP interface [polypeptide binding]; other site 1639008136 dimer interface [polypeptide binding]; other site 1639008137 TPP binding site [chemical binding]; other site 1639008138 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639008139 phosphate binding site [ion binding]; other site 1639008140 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639008141 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1639008142 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639008143 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 1639008144 putative NAD(P) binding site [chemical binding]; other site 1639008145 catalytic Zn binding site [ion binding]; other site 1639008146 structural Zn binding site [ion binding]; other site 1639008147 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639008148 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1639008149 putative NAD(P) binding site [chemical binding]; other site 1639008150 catalytic Zn binding site [ion binding]; other site 1639008151 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1639008152 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 1639008153 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1639008154 active site 1639008155 P-loop; other site 1639008156 phosphorylation site [posttranslational modification] 1639008157 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008158 active site 1639008159 phosphorylation site [posttranslational modification] 1639008160 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639008161 PRD domain; Region: PRD; pfam00874 1639008162 PRD domain; Region: PRD; pfam00874 1639008163 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639008164 active site 1639008165 P-loop; other site 1639008166 phosphorylation site [posttranslational modification] 1639008167 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008168 active site 1639008169 phosphorylation site [posttranslational modification] 1639008170 Predicted membrane protein [Function unknown]; Region: COG4905 1639008171 Predicted membrane protein [Function unknown]; Region: COG4905 1639008172 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1639008173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1639008174 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1639008175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1639008176 active site 1639008177 Helix-turn-helix domain; Region: HTH_18; pfam12833 1639008178 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1639008179 Ligand Binding Site [chemical binding]; other site 1639008180 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1639008181 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1639008182 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1639008183 active site 1639008184 DNA binding site [nucleotide binding] 1639008185 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1639008186 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1639008187 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1639008188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1639008189 active site 1639008190 phosphorylation site [posttranslational modification] 1639008191 intermolecular recognition site; other site 1639008192 dimerization interface [polypeptide binding]; other site 1639008193 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1639008194 DNA binding site [nucleotide binding] 1639008195 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1639008196 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1639008197 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1639008198 Ligand Binding Site [chemical binding]; other site 1639008199 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1639008200 GAF domain; Region: GAF_3; pfam13492 1639008201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1639008202 dimer interface [polypeptide binding]; other site 1639008203 phosphorylation site [posttranslational modification] 1639008204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1639008205 ATP binding site [chemical binding]; other site 1639008206 Mg2+ binding site [ion binding]; other site 1639008207 G-X-G motif; other site 1639008208 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1639008209 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1639008210 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639008211 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1639008212 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639008213 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1639008214 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639008215 methionine cluster; other site 1639008216 active site 1639008217 phosphorylation site [posttranslational modification] 1639008218 metal binding site [ion binding]; metal-binding site 1639008219 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1639008220 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1639008221 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1639008222 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1639008223 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1639008224 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1639008225 autolysin; Reviewed; Region: PRK06347 1639008226 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1639008227 thymidylate kinase; Validated; Region: tmk; PRK00698 1639008228 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1639008229 TMP-binding site; other site 1639008230 ATP-binding site [chemical binding]; other site 1639008231 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1639008232 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1639008233 homodimer interface [polypeptide binding]; other site 1639008234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639008235 catalytic residue [active] 1639008236 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1639008237 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1639008238 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1639008239 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1639008240 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1639008241 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1639008242 DAK2 domain; Region: Dak2; cl03685 1639008243 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1639008244 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639008245 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008246 putative active site [active] 1639008247 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1639008248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639008249 active site 1639008250 motif I; other site 1639008251 motif II; other site 1639008252 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639008253 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1639008254 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1639008255 active site 1639008256 catalytic tetrad [active] 1639008257 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 1639008258 recombination protein RecR; Reviewed; Region: recR; PRK00076 1639008259 RecR protein; Region: RecR; pfam02132 1639008260 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1639008261 putative active site [active] 1639008262 putative metal-binding site [ion binding]; other site 1639008263 tetramer interface [polypeptide binding]; other site 1639008264 hypothetical protein; Validated; Region: PRK00153 1639008265 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1639008266 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1639008267 Domain of unknown function (DUF3284); Region: DUF3284; pfam11687 1639008268 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 1639008269 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1639008270 SH3-like domain; Region: SH3_8; pfam13457 1639008271 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1639008272 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639008273 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1639008274 Walker A/P-loop; other site 1639008275 ATP binding site [chemical binding]; other site 1639008276 Q-loop/lid; other site 1639008277 ABC transporter signature motif; other site 1639008278 Walker B; other site 1639008279 D-loop; other site 1639008280 H-loop/switch region; other site 1639008281 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639008282 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1639008283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639008284 Walker A/P-loop; other site 1639008285 ATP binding site [chemical binding]; other site 1639008286 Q-loop/lid; other site 1639008287 ABC transporter signature motif; other site 1639008288 Walker B; other site 1639008289 D-loop; other site 1639008290 H-loop/switch region; other site 1639008291 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1639008292 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1639008293 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1639008294 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1639008295 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1639008296 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1639008297 nucleoside/Zn binding site; other site 1639008298 catalytic motif [active] 1639008299 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639008300 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639008301 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1639008302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639008303 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639008304 acyl-activating enzyme (AAE) consensus motif; other site 1639008305 acyl-activating enzyme (AAE) consensus motif; other site 1639008306 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1639008307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1639008308 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1639008309 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1639008310 active site 1639008311 trimer interface [polypeptide binding]; other site 1639008312 allosteric site; other site 1639008313 active site lid [active] 1639008314 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1639008315 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1639008316 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1639008317 DNA binding residues [nucleotide binding] 1639008318 drug binding residues [chemical binding]; other site 1639008319 dimer interface [polypeptide binding]; other site 1639008320 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1639008321 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1639008322 Coenzyme A binding pocket [chemical binding]; other site 1639008323 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1639008324 dimer interface [polypeptide binding]; other site 1639008325 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639008326 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639008327 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1639008328 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1639008329 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1639008330 MarR family; Region: MarR; pfam01047 1639008331 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1639008332 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1639008333 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1639008334 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1639008335 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1639008336 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1639008337 DNA binding residues [nucleotide binding] 1639008338 putative dimer interface [polypeptide binding]; other site 1639008339 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1639008340 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639008341 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1639008342 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008343 putative active site [active] 1639008344 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008345 active site 1639008346 phosphorylation site [posttranslational modification] 1639008347 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1639008348 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1639008349 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1639008350 alpha-mannosidase; Provisional; Region: PRK09819 1639008351 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1639008352 active site 1639008353 metal binding site [ion binding]; metal-binding site 1639008354 catalytic site [active] 1639008355 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1639008356 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1639008357 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 1639008358 active site 1639008359 homodimer interface [polypeptide binding]; other site 1639008360 catalytic site [active] 1639008361 glycerate kinase; Region: TIGR00045 1639008362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639008363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639008364 DNA binding site [nucleotide binding] 1639008365 domain linker motif; other site 1639008366 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1639008367 putative dimerization interface [polypeptide binding]; other site 1639008368 putative ligand binding site [chemical binding]; other site 1639008369 Transporter associated domain; Region: CorC_HlyC; pfam03471 1639008370 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1639008371 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1639008372 Domain of unknown function DUF21; Region: DUF21; pfam01595 1639008373 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1639008374 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1639008375 Pathogenicity locus; Region: Cdd1; pfam11731 1639008376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639008377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639008378 putative substrate translocation pore; other site 1639008379 Src Homology 3 domain superfamily; Region: SH3; cl17036 1639008380 Variant SH3 domain; Region: SH3_2; pfam07653 1639008381 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639008382 catalytic residue [active] 1639008383 Class I aldolases; Region: Aldolase_Class_I; cl17187 1639008384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1639008385 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1639008386 ligand binding site [chemical binding]; other site 1639008387 flexible hinge region; other site 1639008388 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1639008389 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639008390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639008391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639008392 Walker A/P-loop; other site 1639008393 ATP binding site [chemical binding]; other site 1639008394 Q-loop/lid; other site 1639008395 ABC transporter signature motif; other site 1639008396 Walker B; other site 1639008397 D-loop; other site 1639008398 H-loop/switch region; other site 1639008399 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1639008400 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1639008401 seryl-tRNA synthetase; Region: serS; TIGR00414 1639008402 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1639008403 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1639008404 dimer interface [polypeptide binding]; other site 1639008405 active site 1639008406 motif 1; other site 1639008407 motif 2; other site 1639008408 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1639008409 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1639008410 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1639008411 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1639008412 substrate-cofactor binding pocket; other site 1639008413 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1639008414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1639008415 catalytic residue [active] 1639008416 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639008417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639008418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639008419 Walker A/P-loop; other site 1639008420 ATP binding site [chemical binding]; other site 1639008421 Q-loop/lid; other site 1639008422 ABC transporter signature motif; other site 1639008423 Walker B; other site 1639008424 D-loop; other site 1639008425 H-loop/switch region; other site 1639008426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1639008427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1639008428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639008429 Walker A/P-loop; other site 1639008430 ATP binding site [chemical binding]; other site 1639008431 ABC transporter; Region: ABC_tran; pfam00005 1639008432 Q-loop/lid; other site 1639008433 ABC transporter signature motif; other site 1639008434 Walker B; other site 1639008435 D-loop; other site 1639008436 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1639008437 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1639008438 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1639008439 Predicted acyl esterases [General function prediction only]; Region: COG2936 1639008440 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1639008441 DNA topoisomerase III; Provisional; Region: PRK07726 1639008442 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1639008443 active site 1639008444 putative interdomain interaction site [polypeptide binding]; other site 1639008445 putative metal-binding site [ion binding]; other site 1639008446 putative nucleotide binding site [chemical binding]; other site 1639008447 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1639008448 domain I; other site 1639008449 DNA binding groove [nucleotide binding] 1639008450 phosphate binding site [ion binding]; other site 1639008451 domain II; other site 1639008452 domain III; other site 1639008453 nucleotide binding site [chemical binding]; other site 1639008454 catalytic site [active] 1639008455 domain IV; other site 1639008456 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1639008457 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1639008458 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1639008459 putative Mg++ binding site [ion binding]; other site 1639008460 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1639008461 nucleotide binding region [chemical binding]; other site 1639008462 ATP-binding site [chemical binding]; other site 1639008463 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1639008464 HRDC domain; Region: HRDC; pfam00570 1639008465 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1639008466 phosphate binding site [ion binding]; other site 1639008467 IMP dehydrogenase/GMP reductase [Nucleotide transport and metabolism]; Region: GuaB; COG0516 1639008468 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1639008469 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1639008470 putative ADP-ribose binding site [chemical binding]; other site 1639008471 putative active site [active] 1639008472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1639008473 ABC transporter; Region: ABC_tran_2; pfam12848 1639008474 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639008475 active site 1639008476 P-loop; other site 1639008477 phosphorylation site [posttranslational modification] 1639008478 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1639008479 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639008480 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639008481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639008482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639008483 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639008484 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639008485 methionine cluster; other site 1639008486 active site 1639008487 phosphorylation site [posttranslational modification] 1639008488 metal binding site [ion binding]; metal-binding site 1639008489 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008490 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639008491 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1639008492 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008493 putative active site [active] 1639008494 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1639008495 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1639008496 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1639008497 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1639008498 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1639008499 Walker A/P-loop; other site 1639008500 ATP binding site [chemical binding]; other site 1639008501 Q-loop/lid; other site 1639008502 ABC transporter signature motif; other site 1639008503 Walker B; other site 1639008504 D-loop; other site 1639008505 H-loop/switch region; other site 1639008506 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1639008507 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1639008508 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1639008509 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1639008510 beta-galactosidase; Region: BGL; TIGR03356 1639008511 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1639008512 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639008513 active site turn [active] 1639008514 phosphorylation site [posttranslational modification] 1639008515 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639008516 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1639008517 HPr interaction site; other site 1639008518 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639008519 active site 1639008520 phosphorylation site [posttranslational modification] 1639008521 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1639008522 CAT RNA binding domain; Region: CAT_RBD; smart01061 1639008523 PRD domain; Region: PRD; pfam00874 1639008524 PRD domain; Region: PRD; pfam00874 1639008525 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1639008526 Switch II region; other site 1639008527 G4 box; other site 1639008528 G5 box; other site 1639008529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1639008530 G1 box; other site 1639008531 GTP/Mg2+ binding site [chemical binding]; other site 1639008532 G2 box; other site 1639008533 Switch I region; other site 1639008534 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1639008535 methionine cluster; other site 1639008536 active site 1639008537 phosphorylation site [posttranslational modification] 1639008538 metal binding site [ion binding]; metal-binding site 1639008539 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1639008540 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1639008541 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1639008542 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1639008543 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1639008544 active site 1639008545 P-loop; other site 1639008546 phosphorylation site [posttranslational modification] 1639008547 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1639008548 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1639008549 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1639008550 HTH domain; Region: HTH_11; pfam08279 1639008551 Mga helix-turn-helix domain; Region: Mga; pfam05043 1639008552 PRD domain; Region: PRD; pfam00874 1639008553 PRD domain; Region: PRD; pfam00874 1639008554 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1639008555 active site 1639008556 P-loop; other site 1639008557 phosphorylation site [posttranslational modification] 1639008558 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008559 active site 1639008560 phosphorylation site [posttranslational modification] 1639008561 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1639008562 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1639008563 tetramer interface [polypeptide binding]; other site 1639008564 heme binding pocket [chemical binding]; other site 1639008565 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1639008566 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1639008567 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1639008568 active site turn [active] 1639008569 phosphorylation site [posttranslational modification] 1639008570 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1639008571 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1639008572 HPr interaction site; other site 1639008573 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1639008574 active site 1639008575 phosphorylation site [posttranslational modification] 1639008576 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1639008577 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1639008578 PRD domain; Region: PRD; pfam00874 1639008579 PRD domain; Region: PRD; pfam00874 1639008580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 1639008581 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1639008582 ParB-like nuclease domain; Region: ParB; smart00470 1639008583 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1639008584 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1639008585 P-loop; other site 1639008586 Magnesium ion binding site [ion binding]; other site 1639008587 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1639008588 Magnesium ion binding site [ion binding]; other site 1639008589 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1639008590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1639008591 non-specific DNA binding site [nucleotide binding]; other site 1639008592 salt bridge; other site 1639008593 sequence-specific DNA binding site [nucleotide binding]; other site 1639008594 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1639008595 ParB-like nuclease domain; Region: ParBc; pfam02195 1639008596 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1639008597 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1639008598 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1639008599 putative active site [active] 1639008600 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1639008601 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1639008602 nucleotide binding site [chemical binding]; other site 1639008603 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1639008604 active site 1639008605 phosphorylation site [posttranslational modification] 1639008606 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1639008607 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1639008608 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1639008609 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1639008610 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1639008611 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1639008612 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639008613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639008614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1639008615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1639008616 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1639008617 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1639008618 putative active site cavity [active] 1639008619 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1639008620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1639008621 S-adenosylmethionine binding site [chemical binding]; other site 1639008622 Protein of unknown function (DUF1310); Region: DUF1310; pfam07006 1639008623 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1639008624 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1639008625 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1639008626 Switch I region; other site 1639008627 G2 box; other site 1639008628 Switch II region; other site 1639008629 G3 box; other site 1639008630 GTP/Mg2+ binding site [chemical binding]; other site 1639008631 G4 box; other site 1639008632 G5 box; other site 1639008633 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1639008634 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1639008635 G1 box; other site 1639008636 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1639008637 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1639008638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1639008639 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1639008640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1639008641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639008642 D-galactonate transporter; Region: 2A0114; TIGR00893 1639008643 putative substrate translocation pore; other site 1639008644 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1639008645 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1639008646 dimer interface [polypeptide binding]; other site 1639008647 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1639008648 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1639008649 metal binding site [ion binding]; metal-binding site 1639008650 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1639008651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1639008652 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1639008653 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1639008654 metal binding site [ion binding]; metal-binding site 1639008655 dimer interface [polypeptide binding]; other site 1639008656 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1639008657 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1639008658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639008659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1639008660 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 1639008661 E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370 1639008662 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639008663 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639008664 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639008665 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1639008666 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1639008667 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1639008668 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1639008669 putative ligand binding site [chemical binding]; other site 1639008670 putative NAD binding site [chemical binding]; other site 1639008671 putative catalytic site [active] 1639008672 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1639008673 L-serine binding site [chemical binding]; other site 1639008674 ACT domain interface; other site 1639008675 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639008676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1639008677 catalytic residue [active] 1639008678 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1639008679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1639008680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639008681 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1639008682 dimer interface [polypeptide binding]; other site 1639008683 FMN binding site [chemical binding]; other site 1639008684 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1639008685 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1639008686 catalytic residues [active] 1639008687 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1639008688 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1639008689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1639008690 motif II; other site 1639008691 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1639008692 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1639008693 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1639008694 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1639008695 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1639008696 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1639008697 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1639008698 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1639008699 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639008700 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1639008701 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1639008702 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1639008703 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1639008704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639008705 dimer interface [polypeptide binding]; other site 1639008706 conserved gate region; other site 1639008707 putative PBP binding loops; other site 1639008708 ABC-ATPase subunit interface; other site 1639008709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1639008710 dimer interface [polypeptide binding]; other site 1639008711 conserved gate region; other site 1639008712 putative PBP binding loops; other site 1639008713 ABC-ATPase subunit interface; other site 1639008714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1639008715 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1639008716 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1639008717 sucrose phosphorylase; Provisional; Region: PRK13840 1639008718 active site 1639008719 homodimer interface [polypeptide binding]; other site 1639008720 catalytic site [active] 1639008721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1639008722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1639008723 DNA binding site [nucleotide binding] 1639008724 domain linker motif; other site 1639008725 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1639008726 putative dimerization interface [polypeptide binding]; other site 1639008727 putative ligand binding site [chemical binding]; other site 1639008728 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1639008729 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1639008730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1639008731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639008732 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639008733 putative substrate translocation pore; other site 1639008734 Domain of unknown function (DUF718); Region: DUF718; cl01281 1639008735 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 1639008736 intersubunit interface [polypeptide binding]; other site 1639008737 active site 1639008738 Zn2+ binding site [ion binding]; other site 1639008739 L-rhamnose isomerase; Provisional; Region: PRK01076 1639008740 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639008741 nucleotide binding site [chemical binding]; other site 1639008742 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1639008743 nucleotide binding site [chemical binding]; other site 1639008744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1639008745 putative substrate translocation pore; other site 1639008746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1639008747 Cupin domain; Region: Cupin_2; pfam07883 1639008748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1639008749 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 1639008750 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1639008751 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1639008752 G-X-X-G motif; other site 1639008753 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1639008754 RxxxH motif; other site 1639008755 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1639008756 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1639008757 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1639008758 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399